Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DOCK5 VPS9D1 NET1 ARHGAP31 TSC2 RPGR ARHGAP39 ARHGEF2 PLXNB1 ACAP3 ADAP2	5.47e-06	507	80	11	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DOCK5 VPS9D1 NET1 ARHGAP31 TSC2 RPGR ARHGAP39 ARHGEF2 PLXNB1 ACAP3 ADAP2	5.47e-06	507	80	11	GO:0030695
GeneOntologyMolecularFunction	GTPase activator activity	DOCK5 VPS9D1 ARHGAP31 TSC2 ARHGAP39 PLXNB1 ACAP3 ADAP2	1.60e-05	279	80	8	GO:0005096
Pathway	BIOCARTA_MSP_PATHWAY	MST1 MST1L IL1B	3.54e-06	7	67	3	MM1580
Pubmed	Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube.	MNX1 DYNC2H1 SMO PCNT	1.75e-07	21	83	4	22007132
Pubmed	Complex interactions between genes controlling trafficking in primary cilia.	MNX1 DYNC2H1 SMO	4.68e-06	14	83	3	21552265
Pubmed	Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.	MST1 MST1L	5.63e-06	2	83	2	29760744
Pubmed	Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3.	MST1 MST1L	5.63e-06	2	83	2	8393443
Pubmed	MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.	MST1 MST1L	5.63e-06	2	83	2	27609031
Pubmed	Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model.	MST1 MST1L	5.63e-06	2	83	2	24980820
Pubmed	Mst1 deletion reduces hyperglycemia-mediated vascular dysfunction via attenuating mitochondrial fission and modulating the JNK signaling pathway.	MST1 MST1L	5.63e-06	2	83	2	31206688
Pubmed	Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein.	MST1 MST1L	5.63e-06	2	83	2	10728827
Pubmed	Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism.	MST1 MST1L	5.63e-06	2	83	2	16961763
Pubmed	Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice.	MST1 MST1L	5.63e-06	2	83	2	39253972
Pubmed	Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway.	MST1 MST1L	5.63e-06	2	83	2	32017081
Pubmed	Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy.	MST1 MST1L	5.63e-06	2	83	2	30708325
Pubmed	Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.	MST1 MST1L	5.63e-06	2	83	2	24409221
Pubmed	Hydrogen sulfide upregulates glutamate-cysteine ligase catalytic subunit, glutamate-cysteine ligase modifier subunit, and glutathione and inhibits interleukin-1β secretion in monocytes exposed to high glucose levels.	GCLC IL1B	5.63e-06	2	83	2	24665821
Pubmed	Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.	MST1 MST1L	5.63e-06	2	83	2	27696525
Pubmed	Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein.	MST1 MST1L	5.63e-06	2	83	2	8340069
Pubmed	Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.	MST1 MST1L	5.63e-06	2	83	2	9486989
Pubmed	Treatment with XMU-MP-1 erases hyperglycaemic memory in hearts of diabetic mice.	MST1 MST1L	5.63e-06	2	83	2	33887258
Pubmed	HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses.	MST1 MST1L	5.63e-06	2	83	2	25938541
Pubmed	Cilia and Hedgehog responsiveness in the mouse.	MNX1 DYNC2H1 SMO	1.24e-05	19	83	3	16061793
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	DOCK5 CYLD NUP155 ESYT1 PI4KB SEC22B RPGR BIRC6 TASOR NUP160	1.64e-05	777	83	10	35844135
Pubmed	The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.	MST1 MST1L	1.69e-05	3	83	2	10225971
Pubmed	Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.	MST1 MST1L	1.69e-05	3	83	2	38430683
Pubmed	Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons.	MST1 MST1L	1.69e-05	3	83	2	12538524
Pubmed	Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.	MST1 MST1L	1.69e-05	3	83	2	19339990
Pubmed	TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1.	MST1 MST1L	1.69e-05	3	83	2	26698664
Pubmed	Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.	MST1 MST1L	1.69e-05	3	83	2	30063115
Pubmed	Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury.	MST1 MST1L	1.69e-05	3	83	2	27218122
Pubmed	Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction.	MST1 MST1L	1.69e-05	3	83	2	17395874
Pubmed	Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane.	NUP155 NUP160	1.69e-05	3	83	2	20974814
Pubmed	Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.	MST1 MST1L	1.69e-05	3	83	2	24852423
Pubmed	Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement.	MST1 MST1L	1.69e-05	3	83	2	27496379
Pubmed	Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cells.	MST1 MST1L	1.69e-05	3	83	2	12804176
Pubmed	Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function.	MST1 MST1L	1.69e-05	3	83	2	12606483
Pubmed	Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice.	MST1 MST1L	1.69e-05	3	83	2	36623453
Pubmed	Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells.	MST1 MST1L	1.69e-05	3	83	2	37184367
Pubmed	CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.	MST1 MST1L	1.69e-05	3	83	2	38288506
Pubmed	The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.	MST1 MST1L	1.69e-05	3	83	2	8545120
Pubmed	Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis.	MST1 MST1L	1.69e-05	3	83	2	25049204
Pubmed	Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development.	MST1 MST1L	1.69e-05	3	83	2	1832957
Pubmed	Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease.	MST1 MST1L	1.69e-05	3	83	2	25183307
Pubmed	MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease.	MST1 MST1L	1.69e-05	3	83	2	35525373
Pubmed	MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice.	MST1 MST1L	1.69e-05	3	83	2	27510910
Pubmed	Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways.	MST1 MST1L	1.69e-05	3	83	2	31976559
Pubmed	Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.	DYNC2H1 SMO	1.69e-05	3	83	2	16229832
Pubmed	Over-expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice.	MST1 MST1L	1.69e-05	3	83	2	32468668
Pubmed	Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting Mst1.	MST1 MST1L	1.69e-05	3	83	2	29127009
Pubmed	Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.	MST1 MST1L	1.69e-05	3	83	2	27465533
Pubmed	Suramin protects hepatocytes from LPS-induced apoptosis by regulating mitochondrial stress and inactivating the JNK-Mst1 signaling pathway.	MST1 MST1L	1.69e-05	3	83	2	30771091
Pubmed	MST1 mediates the N-methyl-D-aspartate-induced excitotoxicity in mouse cortical neurons.	MST1 MST1L	1.69e-05	3	83	2	34967918
Pubmed	Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity.	MST1 MST1L	1.69e-05	3	83	2	38898027
Pubmed	WASP and Mst1 coregulate B-cell development and B-cell receptor signaling.	MST1 MST1L	1.69e-05	3	83	2	32045478
Pubmed	Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2.	MST1 MST1L	1.69e-05	3	83	2	27940445
Pubmed	ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.	MNX1 SMO RPGR	2.56e-05	24	83	3	24797473
Pubmed	Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein.	MST1 MST1L	3.37e-05	4	83	2	21078906
Pubmed	MST1 controls murine neutrophil homeostasis via the G-CSFR/STAT3 axis.	MST1 MST1L	3.37e-05	4	83	2	36618429
Pubmed	Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling.	MST1 MST1L	3.37e-05	4	83	2	35715527
Pubmed	Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.	MST1 MST1L	3.37e-05	4	83	2	25074980
Pubmed	OSM mitigates post-infarction cardiac remodeling and dysfunction by up-regulating autophagy through Mst1 suppression.	MST1 MST1L	3.37e-05	4	83	2	27825852
Pubmed	MST1 deficiency promotes B cell responses by CD4+ T cell-derived IL-4, resulting in hypergammaglobulinemia.	MST1 MST1L	3.37e-05	4	83	2	28527887
Pubmed	Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.	MST1 MST1L	3.37e-05	4	83	2	25133611
Pubmed	LncRNA SNHG17 knockdown promotes Parkin-dependent mitophagy and reduces apoptosis of podocytes through Mst1.	MST1 MST1L	3.37e-05	4	83	2	32627655
Pubmed	Macrophage MST1/2 Disruption Impairs Post-Infarction Cardiac Repair via LTB4.	MST1 MST1L	3.37e-05	4	83	2	34515499
Pubmed	The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.	MST1 MST1L	3.37e-05	4	83	2	22412158
Pubmed	Functional role of Mst1/Mst2 in embryonic stem cell differentiation.	MST1 MST1L	3.37e-05	4	83	2	24224013
Pubmed	Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice.	MST1 MST1L	3.37e-05	4	83	2	26903296
Pubmed	Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis.	MST1 MST1L	3.37e-05	4	83	2	23527007
Pubmed	A cell-intrinsic role for Mst1 in regulating thymocyte egress.	MST1 MST1L	3.37e-05	4	83	2	19692642
Pubmed	Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling.	MST1 MST1L	3.37e-05	4	83	2	28480597
Pubmed	Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion.	MST1 MST1L	3.37e-05	4	83	2	16892067
Pubmed	Hippo signaling pathway reveals a spatio-temporal correlation with the size of primordial follicle pool in mice.	MST1 MST1L	3.37e-05	4	83	2	25659841
Pubmed	Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation.	MST1 MST1L	3.37e-05	4	83	2	26538561
Pubmed	MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS.	MST1 MST1L	3.37e-05	4	83	2	23818595
Pubmed	Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry.	LRRN1 LRRTM3	3.37e-05	4	83	2	20678249
Pubmed	RON (MST1R) and HGFL (MST1) Co-Overexpression Supports Breast Tumorigenesis through Autocrine and Paracrine Cellular Crosstalk.	MST1 MST1L	3.37e-05	4	83	2	35626096
Pubmed	Mammalian sterile 20-like kinase 1 suppresses lymphoma development by promoting faithful chromosome segregation.	MST1 MST1L	3.37e-05	4	83	2	22926556
Pubmed	Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling.	SMO TSC2	3.37e-05	4	83	2	22840514
Pubmed	Treatment with Mammalian Ste-20-like Kinase 1/2 (MST1/2) Inhibitor XMU-MP-1 Improves Glucose Tolerance in Streptozotocin-Induced Diabetes Mice.	MST1 MST1L	3.37e-05	4	83	2	32987643
Pubmed	The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development.	MST1 MST1L	3.37e-05	4	83	2	30386341
Pubmed	A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.	MST1 MST1L	3.37e-05	4	83	2	27919044
Pubmed	Mst1/2 Kinases Modulate Glucose Uptake for Osteoblast Differentiation and Bone Formation.	MST1 MST1L	3.37e-05	4	83	2	29474739
Pubmed	mTORC2 regulates cardiac response to stress by inhibiting MST1.	MST1 MST1L	3.37e-05	4	83	2	25843706
Pubmed	Macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase, inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharide.	MST1 MST1L	3.37e-05	4	83	2	14734766
Pubmed	Thioredoxin-1 functions as a molecular switch regulating the oxidative stress-induced activation of MST1.	MST1 MST1L	3.37e-05	4	83	2	23085515
Pubmed	Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus.	MST1 MST1L	5.60e-05	5	83	2	23033074
Pubmed	Assignment of the gene coding for hepatocyte growth factor-like protein to mouse chromosome 9.	MST1 MST1L	5.60e-05	5	83	2	1354648
Pubmed	Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagy.	MST1 MST1L	5.60e-05	5	83	2	29674007
Pubmed	Tubule-Specific Mst1/2 Deficiency Induces CKD via YAP and Non-YAP Mechanisms.	MST1 MST1L	5.60e-05	5	83	2	32253273
Pubmed	Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver.	MST1 MST1L	5.60e-05	5	83	2	20080689
Pubmed	The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.	MST1 MST1L	5.60e-05	5	83	2	19073936
Pubmed	Mst1-Deficiency Induces Hyperactivation of Monocyte-Derived Dendritic Cells via Akt1/c-myc Pathway.	MST1 MST1L	5.60e-05	5	83	2	31572367
Pubmed	Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis.	MST1 MST1L	5.60e-05	5	83	2	36646002
Pubmed	Genetic evidence supporting the association of protease and protease inhibitor genes with inflammatory bowel disease: a systematic review.	CYLD MST1	5.60e-05	5	83	2	21931648
Pubmed	Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts.	DYNC2H1 SMO	5.60e-05	5	83	2	18488998
Pubmed	A single transcription factor is sufficient to induce and maintain secretory cell architecture.	MST1 MST1L	5.60e-05	5	83	2	28174210
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	DOCK5 ZNF469 NUP155 LRRN1 ARHGAP31 TPX2 PCNT	7.78e-05	430	83	7	35044719
Pubmed	Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice.	MST1 MST1L	8.39e-05	6	83	2	19956688
Pubmed	cDNA cloning and chromosomal mapping of the mouse type VII collagen gene (Col7a1): evidence for rapid evolutionary divergence of the gene.	MST1 MST1L	8.39e-05	6	83	2	8325648
Pubmed	TSC1 controls IL-1β expression in macrophages via mTORC1-dependent C/EBPβ pathway.	TSC2 IL1B	8.39e-05	6	83	2	27593484
Pubmed	Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling.	MST1 MST1L	8.39e-05	6	83	2	21572393
Cytoband	16q24	VPS9D1 ZNF469	4.32e-04	17	83	2	16q24
Cytoband	5p13.1	NUP155 MROH2B	4.85e-04	18	83	2	5p13.1
Cytoband	3p21	MST1 NCKIPSD	1.64e-03	33	83	2	3p21
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	NET1 TRIOBP ARHGEF2 ACAP3 ADAP2	3.08e-04	206	52	5	682
ToppCell	facs-Heart-RA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A1 GUCY1A2 ZSWIM5 LRRTM3 PLXNB1 ADAP2	1.51e-06	190	83	6	bfbdf16d488359d7935a419c4c1823288f39c183
ToppCell	facs-Heart-RA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A1 GUCY1A2 ZSWIM5 LRRTM3 PLXNB1 ADAP2	1.51e-06	190	83	6	eb1f8bb4d903b08e50c2dc173b06c0c79d8e316e
Disease	Muscular Dystrophy	COL6A1 ACHE	2.01e-04	8	80	2	C0026850
Disease	liver cirrhosis (implicated_via_orthology)	GCLC SMO	5.55e-04	13	80	2	DOID:5082 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	MST1 GUCY1A2 NET1 DYNC2H1 ZSWIM5 ACHE ANKEF1 TEKT4 IL1B PLXNB1	6.40e-04	1074	80	10	C0006142
Disease	benign prostatic hyperplasia	GCLC DPEP2	6.47e-04	14	80	2	EFO_0000284
Disease	gamma-glutamylphenylalanine measurement	LRRTM3 ARHGEF2	7.45e-04	15	80	2	EFO_0021142
Disease	matrix metalloproteinase 12 measurement	GUCY1A2 DYNC2H1	1.08e-03	18	80	2	EFO_0010590
Disease	corneal hysteresis	COL6A1 ZNF469	1.34e-03	20	80	2	EFO_0010066
Disease	nephrotic syndrome (biomarker_via_orthology)	NPHS1 IL1B	1.93e-03	24	80	2	DOID:1184 (biomarker_via_orthology)
Disease	inflammatory bowel disease (implicated_via_orthology)	MST1 MST1L	2.09e-03	25	80	2	DOID:0050589 (implicated_via_orthology)
Disease	epiandrosterone sulfate measurement	SLC22A25 MEPCE	2.09e-03	25	80	2	EFO_0021120
Disease	major depressive disorder, COVID-19	GLYAT OAS3	2.26e-03	26	80	2	MONDO_0002009, MONDO_0100096
Disease	cystic fibrosis (is_implicated_in)	GCLC IL1B	2.44e-03	27	80	2	DOID:1485 (is_implicated_in)
Disease	intraocular pressure measurement	COL6A1 ZNF469 DYNC2H1 ZNF516 TRIOBP NUP160	2.62e-03	509	80	6	EFO_0004695
Disease	neuritic plaque measurement	DYNC2H1 MROH2B ARHGEF2 CYP4F11 IQUB	2.62e-03	349	80	5	EFO_0006798
Disease	Visual seizure	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0270824
Disease	Epileptic drop attack	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0270846
Disease	Generalized seizures	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0234533
Disease	Clonic Seizures	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0234535
Disease	Vertiginous seizure	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0422855
Disease	Gustatory seizure	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0422854
Disease	Seizures, Somatosensory	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0422850
Disease	Olfactory seizure	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0422853
Disease	Seizures, Auditory	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0422852
Disease	Generalized Absence Seizures	ACHE TSC2 IL1B	2.64e-03	101	80	3	C4505436
Disease	Convulsive Seizures	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0751494
Disease	Seizures, Sensory	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0751496
Disease	Jacksonian Seizure	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0022333
Disease	Non-epileptic convulsion	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0751056
Disease	Atonic Absence Seizures	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0751123
Disease	Complex partial seizures	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0149958
Disease	Single Seizure	ACHE TSC2 IL1B	2.64e-03	101	80	3	C0751110
Disease	Epileptic Seizures	ACHE TSC2 IL1B	2.64e-03	101	80	3	C4317109
Disease	Nonepileptic Seizures	ACHE TSC2 IL1B	2.64e-03	101	80	3	C3495874

Protein segments in the cluster

Peptide	Gene	Start	Entry
NDTELVACLRTRPAQ	ACHE	296	P22303
PECSSDVNLELRQRN	CAMLG	121	P49069
TQTFCSRVIDEELNP	ESYT1	366	Q9BSJ8
TIGVFRRSNQPDCLE	DIAPH2-AS1	71	Q14236
NATTRQVETELFPCL	AKR7A2	201	O43488
CIQQLTSERFDSPAE	ARID4A	921	P29374
ESCTNSELNSPLVRR	BIRC6	611	Q9NR09
QRLEEQCVDPRLSVS	CBLC	26	Q9ULV8
SQSRLFEEPELTQRC	BTBD6	246	Q96KE9
IQQSVRTCPSREDFP	ARHGEF2	566	Q92974
AGSPTELQFRRCIQE	ACAP3	811	Q96P50
NSTPLNRAIESCRLD	ANKEF1	591	Q9NU02
DRLLQCTRQAVPLFS	API5	236	Q9BZZ5
SRIECESPNNDLSRF	ATP10D	241	Q9P241
FTRQEQINCVTREPL	BAZ1A	756	Q9NRL2
ERRFVLTCPSEKEQQ	ADAP2	336	Q9NPF8
LRCQSDDPRVIFENT	ARHGAP39	1046	Q9C0H5
VQDFLQRCLESPFSR	NET1	286	Q7Z628
PRSSDNRQLLVCEAS	NPHS1	206	O60500
DAPVRSLNCTLRDSQ	IL1B	116	P01584
DEQTLKRRNITSFCP	KPNA7	41	A9QM74
RRVNSDCDSVLPSNF	MEPCE	171	Q7L2J0
SISFPCREQRSQDSR	NPSR1	336	Q6W5P4
EAQPRQEATSVSCFR	MST1L	241	Q2TV78
LINEECRLNRPSSAA	MYO19	486	Q96H55
CRRPRTAFTSQQLLE	MNX1	241	P50219
ERSQRFIERCIQTFP	GLYAT	191	Q6IB77
QRSSDCRILENQPEI	LMLN	496	Q96KR4
TECRNPQELESIRQD	FEM1B	306	Q9UK73
QRVSDQPLESRRLCN	EHHADH	186	Q08426
RNPETCQLFTTELGR	FAM86B1	251	Q8N7N1
LDNICPVNISASFRR	PCYOX1L	371	Q8NBM8
LLPEQQSEQLRCETS	PLXNB1	1206	O43157
RTCSTRNIPVFDENL	MUC19	1196	Q7Z5P9
LRDPNCSSILQTEER	GP2	256	P55259
EENQALCTITSFPRL	GCLC	136	P48506
LSEPLREEIINFTCR	HCN3	406	Q9P1Z3
ECEQPIRRVFQSLSL	PCNT	1251	O95613
TRPVRVFSQENVCDR	CRACDL	106	Q6NV74
ENPSQVLNCERRRFT	NUP155	1336	O75694
FSICSSPRLLEQERV	OXNAD1	111	Q96HP4
RLCSIDYPEREQLQT	DYNC2H1	2426	Q8NCM8
STLFRQSECREVLLP	DOCK5	866	Q9H7D0
RSDTQRDTTPLNVLC	COL6A1	731	P12109
DQACAERRRQTILPS	GFRA2	226	O00451
ELRFRLLDPRTQQEC	FNDC11	241	Q9BVV2
FTDAVIQERRCTLPT	CYP4F11	266	Q9HBI6
RNQEKPSTLTRFCES	CERS6	121	Q6ZMG9
RIPERLSIFCRDTQT	IQUB	276	Q8NA54
VPCQTQDRDALRLTL	DPEP2	136	Q9H4A9
EAQPRQEATTVSCFR	MST1	271	P26927
NITDLLEDTPRQCRI	CYLD	776	Q9NQC7
FRKLNEQSPTRCTLE	SEC22B	41	O75396
CSTAQENELIPSIIR	SLC22A25	451	Q6T423
RFSDTLRILTCEPSQ	PRIMPOL	336	Q96LW4
VDCNDLRLTRIPSNL	LRRN1	56	Q6UXK5
CFTELQRDFIISRPT	OAS3	926	Q9Y6K5
QVPADLRISINTFCR	GUCY1A2	311	P33402
VFPRCSERNLQESVL	RPGR	446	Q92834
SNSLRTIPVRIFQDC	LRRTM3	166	Q86VH5
PFSITTDNLQCRERR	TEKT4	136	Q8WW24
TPETRAKFTQDNLCR	TEKT4	241	Q8WW24
DTIRSRLDNICQSPL	SH3TC2	1251	Q8TF17
ANLTCDQLADRRSPV	SLC6A8	196	P48029
EQLTTRLQALRQDPC	MROH2B	1546	Q7Z745
NRIRSTRSVENLPEC	PI4KB	421	Q9UBF8
LTQIPDSSRQLDCLR	NUP160	1021	Q12769
ILRRILNEEETSPQC	NCKIPSD	686	Q9NZQ3
TIQQENPRTSCALRD	TRIOBP	666	Q9H2D6
ENLRTSCTRQDNPRT	TRIOBP	766	Q9H2D6
SQTRNAPELDCLIRL	TASOR	1411	Q9UK61
ECQPLLLARFTRTQV	ZNF516	826	Q92618
SLCSDRILQDVPFNR	ZYG11B	431	Q9C0D3
PACQRESERLLFNSQ	ZSWIM5	516	Q9P217
ELLRSSCPQERLQQE	TSNARE1	321	Q96NA8
QTCSERRPIRNLTFQ	VSIR	81	Q9H7M9
ARRDADTQTPLLCSQ	TMEM116	206	Q8NCL8
RLRQEFGSDQCPDLT	ARHGAP31	66	Q2M1Z3
NDRVELPSRTLCQAT	SMO	136	Q99835
QESEDSLRLLPCEQR	ZNF469	1731	Q96JG9
ECRQRLIFEQTPALT	ZNF8	426	P17098
RFCSQVALTPEEREQ	VPS9D1	221	Q9Y2B5
VVTCPDLSRRRNFDN	ZP4	456	Q12836
VERCADQRPESSLLN	TSC2	411	P49815
NVTQIEPFCLETDRR	TPX2	586	Q9ULW0