Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	HELP	EML4 EML2 EML3 EML1	2.41e-08	6	120	4	PF03451
Domain	HELP	EML4 EML2 EML3 EML1	2.41e-08	6	120	4	IPR005108
Domain	TF_T-box	TBX15 TBX3 TBX21 EOMES TBX10	5.86e-08	17	120	5	IPR001699
Domain	TBOX	TBX15 TBX3 TBX21 EOMES TBX10	5.86e-08	17	120	5	SM00425
Domain	TF_T-box_CS	TBX15 TBX3 TBX21 EOMES TBX10	5.86e-08	17	120	5	IPR018186
Domain	-	TBX15 TBX3 TBX21 EOMES TBX10	5.86e-08	17	120	5	2.60.40.820
Domain	TBOX_3	TBX15 TBX3 TBX21 EOMES TBX10	5.86e-08	17	120	5	PS50252
Domain	T-box	TBX15 TBX3 TBX21 EOMES TBX10	5.86e-08	17	120	5	PF00907
Domain	TBOX_1	TBX15 TBX3 TBX21 EOMES TBX10	5.86e-08	17	120	5	PS01283
Domain	TBOX_2	TBX15 TBX3 TBX21 EOMES TBX10	5.86e-08	17	120	5	PS01264
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	7.71e-07	12	120	4	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	7.71e-07	12	120	4	IPR027970
Domain	Quinoprotein_ADH-like_supfam	DMXL2 EML4 EML2 EML3 EML1 EIF2AK3	1.11e-06	53	120	6	IPR011047
Domain	p53-like_TF_DNA-bd	TBX15 TBX3 TBX21 EOMES TBX10	2.26e-05	53	120	5	IPR008967
Domain	PAD	PADI6 PADI2	4.04e-04	5	120	2	PF03068
Domain	PAD_N	PADI6 PADI2	4.04e-04	5	120	2	PF08526
Domain	PAD_M	PADI6 PADI2	4.04e-04	5	120	2	PF08527
Domain	PAD	PADI6 PADI2	4.04e-04	5	120	2	IPR004303
Domain	PAD_C	PADI6 PADI2	4.04e-04	5	120	2	IPR013530
Domain	Prot_Arg_deaminase_cen_dom	PADI6 PADI2	4.04e-04	5	120	2	IPR013733
Domain	PAD_N	PADI6 PADI2	4.04e-04	5	120	2	IPR013732
Domain	ZnF_C2HC	RBBP6 SLU7 FAM90A1 FAM90A27P	4.29e-04	55	120	4	SM00343
Domain	Znf_CCHC	RBBP6 SLU7 FAM90A1 FAM90A27P	4.29e-04	55	120	4	IPR001878
Domain	Nuclear_transport_factor_2_euk	G3BP1 G3BP2	1.12e-03	8	120	2	IPR018222
Domain	NTF2	G3BP1 G3BP2	1.12e-03	8	120	2	PF02136
Domain	NTF2_DOMAIN	G3BP1 G3BP2	1.43e-03	9	120	2	PS50177
Domain	NTF2	G3BP1 G3BP2	1.43e-03	9	120	2	IPR002075
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1	3.59e-12	6	127	5	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1	3.59e-12	6	127	5	25930072
Pubmed	Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain.	EML4 EML2 EML3 EML1	5.88e-09	7	127	4	25740311
Pubmed	A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family.	TBX15 TBX3 EOMES TBX10	1.17e-08	8	127	4	9503012
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1	2.41e-08	24	127	5	32212159
Pubmed	Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression.	TBX15 TBX3 TBX21 EOMES TBX10	1.31e-07	33	127	5	18356246
Pubmed	Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain.	EML4 EML2 EML1	9.43e-07	6	127	3	24706829
Pubmed	Human transcription factor protein interaction networks.	RBBP6 USP9X COX6C SLC5A9 C15orf39 SLU7 LGALS3BP GTF3C1 ALMS1 G3BP1 MRPS25 G3BP2 XRN1 AUTS2 SMARCD2 TAF2 PAX7 SGF29	4.67e-06	1429	127	18	35140242
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	NOA1 PFAS FASTKD2 ADAR TRUB2 LGALS3BP ALMS1 G3BP1 G3BP2	8.18e-06	364	127	9	24778252
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	RBBP6 USP9X NOA1 FASTKD2 ADAR THOC5 TRUB2 GTF3C1 G3BP1 MRPS25 CFAP20 G3BP2	1.26e-05	713	127	12	29802200
Pubmed	Inflammation programs self-reactive CD8+ T cells to acquire T-box-mediated effector function but does not prevent deletional tolerance.	TBX21 EOMES	1.32e-05	2	127	2	24823810
Pubmed	Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells.	TBX21 EOMES	1.32e-05	2	127	2	16204645
Pubmed	Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin.	TBX21 EOMES	1.32e-05	2	127	2	16273099
Pubmed	Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection.	G3BP1 G3BP2	1.32e-05	2	127	2	23087212
Pubmed	T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells.	TBX21 EOMES	1.32e-05	2	127	2	34630413
Pubmed	Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche.	TBX21 EOMES	1.32e-05	2	127	2	20935204
Pubmed	Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.	TBX21 EOMES	1.32e-05	2	127	2	23197535
Pubmed	Eomes+T-betlow CD8+ T Cells Are Functionally Impaired and Are Associated with Poor Clinical Outcome in Patients with Acute Myeloid Leukemia.	TBX21 EOMES	1.32e-05	2	127	2	30709927
Pubmed	IL-12 Influence mTOR to Modulate CD8+ T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis.	TBX21 EOMES	1.32e-05	2	127	2	28924369
Pubmed	Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.	USP9X USP9Y	1.32e-05	2	127	2	12895410
Pubmed	Characterization of eomesodermin and T-bet expression by allostimulated CD8+ T cells of healthy volunteers and kidney transplant patients in relation to graft outcome.	TBX21 EOMES	1.32e-05	2	127	2	30246373
Pubmed	The low EOMES/TBX21 molecular phenotype in multiple sclerosis reflects CD56+ cell dysregulation and is affected by immunomodulatory therapies.	TBX21 EOMES	1.32e-05	2	127	2	26762769
Pubmed	The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease.	TBX21 EOMES	1.32e-05	2	127	2	24495857
Pubmed	Eomes is sufficient to regulate IL-10 expression and cytotoxic effector molecules in murine CD4+ T cells.	TBX21 EOMES	1.32e-05	2	127	2	36756120
Pubmed	The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.	USP9X USP9Y	1.32e-05	2	127	2	8922996
Pubmed	Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery.	G3BP1 G3BP2	1.32e-05	2	127	2	31199850
Pubmed	T-bet and Eomes govern differentiation and function of mouse and human NK cells and ILC1.	TBX21 EOMES	1.32e-05	2	127	2	29424438
Pubmed	Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication.	G3BP1 G3BP2	1.32e-05	2	127	2	25653451
Pubmed	Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2).	EML2 EML1	1.32e-05	2	127	2	10521658
Pubmed	Elevated pigment epithelium-derived factor induces diabetic erectile dysfunction via interruption of the Akt/Hsp90β/eNOS complex.	SERPINF1 LEPR	1.32e-05	2	127	2	32377760
Pubmed	Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells.	TBX21 EOMES	1.32e-05	2	127	2	17312115
Pubmed	Control of effector CD8+ T cell function by the transcription factor Eomesodermin.	TBX21 EOMES	1.32e-05	2	127	2	14605368
Pubmed	Differential effect of SARS-CoV-2 infection on stress granule formation in Vero and Calu-3 cells.	G3BP1 G3BP2	1.32e-05	2	127	2	36081788
Pubmed	Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells.	TBX21 EOMES	1.32e-05	2	127	2	32991634
Pubmed	NK Cell Functional Impairment after Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with Reduced Levels of T-bet and Eomesodermin.	TBX21 EOMES	1.32e-05	2	127	2	26438526
Pubmed	Differential localization of T-bet and Eomes in CD8 T cell memory populations.	TBX21 EOMES	1.32e-05	2	127	2	23455505
Pubmed	Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.	USP9X USP9Y	1.32e-05	2	127	2	12925892
Pubmed	T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection.	TBX21 EOMES	1.32e-05	2	127	2	25032686
Pubmed	Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis.	LEPR CLK2	1.32e-05	2	127	2	20074525
Pubmed	Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors.	TBX21 EOMES	1.32e-05	2	127	2	22490682
Pubmed	T-BET and EOMES sustain mature human NK cell identity and antitumor function.	TBX21 EOMES	1.32e-05	2	127	2	37279078
Pubmed	Molecular determinants for regulation of G3BP1/2 phase separation by the SARS-CoV-2 nucleocapsid protein.	G3BP1 G3BP2	1.32e-05	2	127	2	34400613
Pubmed	Bona Fide Th17 Cells without Th1 Functional Plasticity Protect against Influenza.	TBX21 EOMES	1.32e-05	2	127	2	35338093
Pubmed	High levels of pigment epithelium-derived factor in diabetes impair wound healing through suppression of Wnt signaling.	SERPINF1 LEPR	1.32e-05	2	127	2	25368097
Pubmed	Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation.	G3BP1 G3BP2	1.32e-05	2	127	2	34517025
Pubmed	Eomesodermin and T-bet mark developmentally distinct human natural killer cells.	TBX21 EOMES	1.32e-05	2	127	2	28289707
Pubmed	G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.	G3BP1 G3BP2	1.32e-05	2	127	2	33497611
Pubmed	The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation.	TBX21 EOMES	1.32e-05	2	127	2	22261438
Pubmed	Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis.	LEPR ALMS1	1.32e-05	2	127	2	28842428
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	FLII RBBP6 SIPA1L3 SLU7 DDX55 ADAR THOC5 LGALS3BP CYFIP1 GTF3C1 G3BP1 MRPS25 SRGAP1 G3BP2 CRYBG1 SMARCD2	1.46e-05	1257	127	16	36526897
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FLII ZSWIM8 DMXL2 HIVEP2 USP9X ITSN1 SIPA1L3 ASH1L NCKAP5 USP9Y LRRC4 SYNJ1 ARL13B EIF4G2 PPME1 PADI2	1.90e-05	1285	127	16	35914814
Pubmed	Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.	FAM90A1 FAM90A27P LEPR F13A1 LGALS3BP FAM90A26	3.24e-05	164	127	6	22967998
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	RBBP6 USP9X ADAR CYFIP1 LATS1 GTF3C1 ALMS1 SYNJ1 XRN1 TAF2	3.56e-05	549	127	10	38280479
Pubmed	Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.	PPFIA2 ITSN1 SYNJ1	3.73e-05	18	127	3	27984743
Pubmed	[Role of transcription factor T-bet and Eomes in IFN-gamma secretion of different human T cell subsets].	TBX21 EOMES	3.96e-05	3	127	2	20056084
Pubmed	T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17.	TBX21 EOMES	3.96e-05	3	127	2	19050290
Pubmed	Cutting Edge: Divergent Requirement of T-Box Transcription Factors in Effector and Memory NK Cells.	TBX21 EOMES	3.96e-05	3	127	2	29440505
Pubmed	The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin.	TBX21 EOMES	3.96e-05	3	127	2	20060330
Pubmed	The G3BP1-Family-USP10 Deubiquitinase Complex Rescues Ubiquitinated 40S Subunits of Ribosomes Stalled in Translation from Lysosomal Degradation.	G3BP1 G3BP2	3.96e-05	3	127	2	31981475
Pubmed	Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions.	TBX21 FGD5	3.96e-05	3	127	2	35348580
Pubmed	PERK in POMC neurons connects celastrol with metabolism.	LEPR EIF2AK3	3.96e-05	3	127	2	34549728
Pubmed	The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration.	PAX7 EIF2AK3	3.96e-05	3	127	2	28332979
Pubmed	Activation of transient receptor potential vanilloid 3 channel suppresses adipogenesis.	LEPR TRPV3	3.96e-05	3	127	2	25774551
Pubmed	T-bet and eomesodermin are required for T cell-mediated antitumor immune responses.	TBX21 EOMES	3.96e-05	3	127	2	20713880
Pubmed	Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis.	TBX21 EOMES	3.96e-05	3	127	2	12128215
Pubmed	IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8+ T Cells Responding to Persistent LCMV Infection.	TBX21 EOMES	3.96e-05	3	127	2	26714260
Pubmed	RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation.	G3BP1 G3BP2	3.96e-05	3	127	2	32302572
Pubmed	G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.	G3BP1 G3BP2	3.96e-05	3	127	2	32302571
Pubmed	Active STAT5 regulates T-bet and eomesodermin expression in CD8 T cells and imprints a T-bet-dependent Tc1 program with repressed IL-6/TGF-β1 signaling.	TBX21 EOMES	3.96e-05	3	127	2	24006458
Pubmed	SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production.	G3BP1 G3BP2	3.96e-05	3	127	2	33495715
Pubmed	Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances.	LEPR ALMS1	3.96e-05	3	127	2	27757953
Pubmed	Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells.	TBX21 EOMES	3.96e-05	3	127	2	34521844
Pubmed	T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model.	TBX21 EOMES	3.96e-05	3	127	2	28550044
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	SPAG1 ZFYVE16 SIPA1L3 CEMIP2 SYNJ1 EPHA2 EIF4G2 XRN1 PPME1 CRYBG1	4.52e-05	565	127	10	25468996
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	FLII TBX3 RBBP6 SIPA1L3 PFAS THOC5 TRUB2 CYFIP1 LATS1 G3BP1 CFAP20 EPHA2 G3BP2 EIF4G2 XRN1	5.23e-05	1247	127	15	27684187
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	RBBP6 GTF3C1 ALMS1 CLK2 CFAP20 CRYBG1 SMARCD2 TAF2 UNC79	5.94e-05	469	127	9	27634302
Pubmed	Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate.	DCC EOMES NTN4	6.96e-05	22	127	3	22726835
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	EML4 USP9X COX6C EML2 PFAS EML3 LGALS3BP G3BP1 TELO2 CLK2 MRPS25 CFAP20 G3BP2 EIF4G2 UNC79	7.25e-05	1284	127	15	17353931
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	FLII EML4 DDX55 ADAR THOC5 G3BP1 EPHA2 G3BP2 XRN1 SMARCD2 TAF2	7.38e-05	724	127	11	36232890
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SPAG1 PPFIA2 ITSN1 SIPA1L3 ASH1L COX6C DCC PLA2G4D DDX55 RBMXL2 LATS1 GTF3C1 MRPS25 XRN1 SMARCD2 PADI6	7.52e-05	1442	127	16	35575683
Pubmed	Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP).	G3BP1 G3BP2	7.90e-05	4	127	2	17297477
Pubmed	DNA-array of gene variants in venous leg ulcers: detection of prognostic indicators.	F13A1 MMP12	7.90e-05	4	127	2	19958990
Pubmed	IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells.	TBX21 EOMES	7.90e-05	4	127	2	21887788
Pubmed	Obesity-Induced Infertility in Male Mice Is Associated With Disruption of Crisp4 Expression and Sperm Fertilization Capacity.	LEPR CRISP1	7.90e-05	4	127	2	28911169
Pubmed	Both G3BP1 and G3BP2 contribute to stress granule formation.	G3BP1 G3BP2	7.90e-05	4	127	2	23279204
Pubmed	Surviving the crash: transitioning from effector to memory CD8+ T cell.	TBX21 EOMES	7.90e-05	4	127	2	19269192
Pubmed	Cutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin.	TBX21 EOMES	7.90e-05	4	127	2	21076068
Pubmed	The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.	TBX21 EOMES	7.90e-05	4	127	2	24663216
Pubmed	TCF-1 negatively regulates the suppressive ability of canonical and noncanonical Tregs.	TBX21 EOMES	7.90e-05	4	127	2	36806938
Pubmed	ADAR1 inhibits adipogenesis and obesity by interacting with Dicer to promote the maturation of miR-155-5P.	ADAR LEPR	7.90e-05	4	127	2	35067718
Pubmed	The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8αα(+) intraepithelial lymphocyte development.	TBX21 EOMES	7.90e-05	4	127	2	25148024
Pubmed	ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.	TBX21 EIF2AK3	7.90e-05	4	127	2	30894532
Pubmed	The polycomb protein Ezh2 regulates differentiation and plasticity of CD4(+) T helper type 1 and type 2 cells.	TBX21 EOMES	7.90e-05	4	127	2	24238339
Pubmed	PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease.	PADI6 PADI2	7.90e-05	4	127	2	14579251
Pubmed	The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation.	TBX3 EOMES	7.90e-05	4	127	2	23584530
Pubmed	Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine.	LEPR PAX7	7.90e-05	4	127	2	35649375
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DMXL2 ITSN1 C1orf43 COX6C SLU7 PFAS FASTKD2 THOC5 CEMIP2 LGALS3BP TELO2 MRPS25 EPHA2 ARL13B EIF4G2 EIF2AK3	1.07e-04	1487	127	16	33957083
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	USP9X CYFIP1 LATS1 GTF3C1 G3BP1 EPHA2 G3BP2 EIF4G2	1.14e-04	399	127	8	37536630
Pubmed	Tbt-1, a new T-box transcription factor induced in activated Th1 and CD8+ T cells.	TBX21 EOMES	1.31e-04	5	127	2	10970091
Pubmed	IL-4 acts as a potent stimulator of IFN-γ expression in CD8+ T cells through STAT6-dependent and independent induction of Eomesodermin and T-bet.	TBX21 EOMES	1.31e-04	5	127	2	22078635
Cytoband	10p14	ITIH5 DHTKD1 CELF2-AS1	5.13e-05	26	127	3	10p14
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	2.10e-04	8	127	2	chr9q12
Cytoband	Ensembl 112 genes in cytogenetic band chr10p14	ITIH5 DHTKD1 CELF2-AS1	3.47e-04	49	127	3	chr10p14
Cytoband	1p36.13	PADI6 PAX7 PADI2	5.15e-04	56	127	3	1p36.13
Cytoband	Xq22	GUCY2F FRMPD3	1.69e-03	22	127	2	Xq22
Cytoband	8q22.2	SPAG1 COX6C	1.85e-03	23	127	2	8q22.2
Cytoband	9p13.1	SPATA31A3 SPATA31A1	2.01e-03	24	127	2	9p13.1
Cytoband	5q33.1	IL17B G3BP1	2.36e-03	26	127	2	5q33.1
GeneFamily	T-boxes	TBX15 TBX3 TBX21 EOMES TBX10	1.39e-08	18	82	5	766
GeneFamily	Peptidyl arginine deiminases	PADI6 PADI2	2.01e-04	5	82	2	677
Coexpression	GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_24H_IFNG_STIM_UP	CHL1 HIVEP2 ASH1L LGALS3BP ITIH5 EOMES ADPRM CRYBG1	4.86e-06	200	123	8	M6307
Coexpression	GSE33425_CD8_ALPHAALPHA_VS_ALPHABETA_CD161_HIGH_TCELL_UP	HIVEP2 ITSN1 ASH1L TRIM11 MS4A1 CLK2 EIF4G2 SMARCD2	4.86e-06	200	123	8	M8547
ToppCell	COPD-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	ENOX1 SIPA1L3 SERPINF1 NCKAP5 SNX8 AUTS2 CRYBG1 DHTKD1 PADI2	3.08e-09	184	127	9	42d7ce104cd7bcb83fbbbd0e7d3267ad07edfa94
ToppCell	IPF-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	SIPA1L3 SERPINF1 NCKAP5 SNX8 AUTS2 CRYBG1 DHTKD1 PADI2	6.46e-08	186	127	8	962c2dada19185628ead77c32fcb07fa95114247
ToppCell	IPF-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	ENOX1 SIPA1L3 SERPINF1 NCKAP5 AUTS2 CRYBG1 DHTKD1 PADI2	7.02e-08	188	127	8	47bb6caf84f70a1cda7d09803afdfd5182772e66
ToppCell	IPF-Myeloid-cDC1\|IPF / Disease state, Lineage and Cell class	SIPA1L3 SERPINF1 NCKAP5 SNX8 AUTS2 CRYBG1 DHTKD1 PADI2	7.02e-08	188	127	8	2331a2bae1383820d598e93aa86c75b101069bac
ToppCell	COPD-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	ENOX1 SIPA1L3 SERPINF1 NCKAP5 AUTS2 CRYBG1 DHTKD1 PADI2	7.93e-08	191	127	8	3480e6d27dd4291765bbbb2acdb6a2e4f02c8085
ToppCell	COPD-Myeloid-cDC1\|COPD / Disease state, Lineage and Cell class	ENOX1 SIPA1L3 SERPINF1 NCKAP5 SNX8 AUTS2 DHTKD1 PADI2	8.26e-08	192	127	8	bd3d00b094d92463b06023361a71240851a542b8
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CHL1 HIVEP2 ENOX1 DGKG CEMIP2 AUTS2 PADI2	8.39e-07	179	127	7	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	356C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SIPA1L3 TBX21 CEMIP2 EOMES MS4A1 AJM1 FRMPD3	8.71e-07	180	127	7	f24d4cbba4cb50fce3b3d9c4629aa856d9b05358
ToppCell	Control-Myeloid-cDC1\|Control / Disease state, Lineage and Cell class	SIPA1L3 SERPINF1 SNX8 AUTS2 CRYBG1 DHTKD1 PADI2	1.08e-06	186	127	7	b05c394aa3573ba855abc3066739ca193883b0c3
ToppCell	Control-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	SIPA1L3 SERPINF1 SRGAP1 SNX8 AUTS2 CRYBG1 PADI2	1.39e-06	193	127	7	4cb938c346cc32ec122d11e6b9f25db20e0f7ff6
ToppCell	IPF-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	SIPA1L3 SERPINF1 SRGAP1 SNX8 AUTS2 CRYBG1 PADI2	1.44e-06	194	127	7	accf4b7b09e2048f2e47a52201e0158684dda8fe
ToppCell	Transverse-(5)_Dendritic_cell-(53)_Lymphoid_DC\|Transverse / shred on region, Cell_type, and subtype	TRPM4 DMXL2 ENOX1 SLC22A23 ITSN1 SERPINF1 SRGAP1	1.59e-06	197	127	7	15b87fd3906d7388c271d30d0c64b1bcc490801c
ToppCell	Transverse-Dendritic_cell-Lymphoid_DC\|Transverse / Region, Cell class and subclass	TRPM4 DMXL2 ENOX1 SLC22A23 ITSN1 SERPINF1 SRGAP1	1.59e-06	197	127	7	a58af0ea82f76f2a7abac1f62629ff20d552fc63
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 SIPA1L3 GRHL2 RBMXL2 EML1 UNC79	7.96e-06	165	127	6	6d315e0734079ad05336cc2c3f24d870c9105bc8
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 SIPA1L3 GRHL2 RBMXL2 EML1 UNC79	7.96e-06	165	127	6	84f5597b1bb75f42de9a224196bb8ac198bbe3bf
ToppCell	pdx-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CHL1 HIVEP2 ENOX1 DGKG CEMIP2 PADI2	1.39e-05	182	127	6	7b24a4f712e1ae1525e8f1c8ec4e1fc43489cbee
ToppCell	droplet-Kidney-nan-3m-Endothelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBX3 CEMIP2 SRGAP1 FGD5 RFLNA EML1	1.39e-05	182	127	6	f4a5f1c3a04c0566eb96607dab7a0d9a5ebc3fd1
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPFIA2 DCC GUCY2F PTPRQ DNAH9 UNC79	1.48e-05	184	127	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPFIA2 DCC GUCY2F PTPRQ DNAH9 UNC79	1.48e-05	184	127	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPFIA2 DCC GUCY2F PTPRQ DNAH9 UNC79	1.48e-05	184	127	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Control-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	SIPA1L3 SERPINF1 SNX8 AUTS2 DHTKD1 PADI2	1.57e-05	186	127	6	3de803dee3ef10eb85a2b47d3f93385214e5b0ff
ToppCell	COPD-Myeloid-DC_Mature\|COPD / Disease state, Lineage and Cell class	ENOX1 SLC22A23 SIPA1L3 SERPINF1 SRGAP1 AUTS2	1.67e-05	188	127	6	de93ccb53edb8599da9e312db0e3af604c21f673
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ENOX1 SIPA1L3 SERPINF1 SNX8 CRYBG1 PADI2	1.67e-05	188	127	6	d5ce3ffe783c322b4765b790e861727e46bc34b3
ToppCell	Control-Myeloid-cDC2\|Control / Disease state, Lineage and Cell class	SIPA1L3 SERPINF1 SRGAP1 SNX8 CRYBG1 PADI2	1.77e-05	190	127	6	4e481e42353d47af7991744000403af2873f6a41
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TBX3 NCKAP5 LEPR ITIH5 FGD5 EML1	1.77e-05	190	127	6	106ea0bb7b99c697ffc5443d72343df2484250c7
ToppCell	IPF-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	SERPINF1 F13A1 SRGAP1 SNX8 CRYBG1 PADI2	1.83e-05	191	127	6	9fda87fb6bc5b8b6c0214ec909ebbc9f3f65319b
ToppCell	COPD-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	SIPA1L3 SRGAP1 SNX8 AUTS2 CRYBG1 PADI2	1.88e-05	192	127	6	984cdc2f1d93e164bc946d63f58dacb629f82eb7
ToppCell	COPD-Lymphoid-T_Cytotoxic\|World / Disease state, Lineage and Cell class	TBX21 PBX4 CEMIP2 EOMES AUTS2 CRYBG1	1.88e-05	192	127	6	5bfd9f5d47511441eb2d3cc3c4d7ed330ffd0bd1
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-T-T_CD8-MAIT\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	EML4 TBX21 PBX4 EOMES G3BP2 AUTS2	1.94e-05	193	127	6	9aeb34d7a24f84abff38d7b8cf0ec707c08eb27f
ToppCell	Monocytes-M2-like_CD16+_macrophages\|World / Immune cells in Kidney/Urine in Lupus Nephritis	ITSN1 LRRC4 F13A1 LGALS3BP CYFIP1 SRGAP1	2.05e-05	195	127	6	10fa47bdcf6c9784ea930b75a5861e139421feed
ToppCell	Transverse-Dendritic_cell-Lymphoid_DC\|Dendritic_cell / Region, Cell class and subclass	ENOX1 SLC22A23 ITSN1 USP9Y MS4A1 SRGAP1	2.17e-05	197	127	6	8545baf923ddf84c5ce9414a36d810603be52401
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TBX3 ENOX1 PPFIA2 LEPR F13A1 ITIH5	2.17e-05	197	127	6	44673c38384453207871d3fd8e8ba9093cc06bc5
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	CHL1 HIVEP2 PPFIA2 SRGAP1 AUTS2 EML1	2.30e-05	199	127	6	058373b4ac3cec2108cb24265628ff0a50646e33
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-BMP_responsible_cell\|6m / Sample Type, Dataset, Time_group, and Cell type.	SPAG1 ZFYVE16 CAPSL SERPINF1 LEPR MAP3K19	2.37e-05	200	127	6	5fb90118d3abc28d72bc483e68317255090a04c7
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	CHL1 ITSN1 SERPINF1 CEMIP2 ITIH5 SRGAP1	2.37e-05	200	127	6	a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TBX3 ENOX1 LEPR F13A1 ITIH5 AHRR	2.37e-05	200	127	6	58b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell	3'_v3-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	EML4 ASH1L USP9Y CEMIP2 MMP12	2.53e-05	121	127	5	19333a660800b583fa27b495c1f7828e6636a257
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4-_Ptgds_(Bmp4)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	IL17B USP9Y PLA2G4D GUCY2F	7.35e-05	78	127	4	87ed71a692416a21c8c11b5adbfe629f7d57ddb4
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4-_Ptgds_(Bmp4)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	IL17B USP9Y PLA2G4D GUCY2F	7.35e-05	78	127	4	9545ae56fda3893b82b5efa82082e1f585a5f92a
ToppCell	facs-Spleen-nan-24m-Lymphocytic-NK_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENOX1 TBX21 LGALS3BP EOMES PADI2	8.00e-05	154	127	5	bd283c2367afb99294e7576a0c0167eb7c69ad6b
ToppCell	COVID-19-Heart-CM_5_(RYR2-)\|Heart / Disease (COVID-19 only), tissue and cell type	TBX15 SLC22A23 CYREN PTPRQ PADI2	8.25e-05	155	127	5	d7e26696fd9c0a759524f331243db43059b33ed9
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PHF7 PFAS MS4A1 TRPV3 DHTKD1	8.50e-05	156	127	5	7ece590fd8f29382e349dd0e5e016d2926aeb518
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_macrophage-microglial_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SERPINF1 SLC5A9 CYFIP1 SRGAP1 PADI2	8.76e-05	157	127	5	d4908cafd8870c1c225817f589ea2bce116ac7ab
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P5-P5_1-Sox4-POLYDENDROCYTE_(Rostral-�migratory_stream-�(RMS)_(Hist1h2al))\|Striatum / BrainAtlas - Mouse McCarroll V32	USP9Y EOMES PADI6 PAX7	8.93e-05	82	127	4	3cee9ee752128dd91e9abc05c9f97b17e64a2a76
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	EML4 ASH1L PBX4 USP9Y CRYBG1	1.02e-04	162	127	5	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-Cajal-Retzius\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	SERPINF1 DCC NTN4 SV2B FGD5	1.04e-04	163	127	5	c1484e4de8b10e2f5fb14a7c02b2a015ffe0305e
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 SPAG1 SERPINF1 LRRC4 ALDH6A1	1.04e-04	163	127	5	1eec7f5e5fed05fa21d3f81db588f10605f08ea7
ToppCell	343B-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ENOX1 SLC22A23 SERPINF1 AUTS2 RBM41	1.08e-04	164	127	5	eae6d440877b292ad18dc4bd02802dda5b2f9c60
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231\|Adult / Lineage, Cell type, age group and donor	CHL1 TBX3 CRISP1 FGD5 EML1	1.17e-04	167	127	5	5af9127bae05768a5164d5708a4ad37edca99324
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-NK_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 TBX21 ITIH5 EOMES PADI2	1.17e-04	167	127	5	aef22535a76e93472bcedacbb2c6991f3c9c8cd5
ToppCell	droplet-Liver-HEPATOCYTES-1m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBX21 TRIM11 JMJD7 XRN1 FCHSD1	1.24e-04	169	127	5	d721dbb317a88113b4f76688111908d00f23e899
ToppCell	facs-Lung-nan-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 LEPR CEMIP2 CYFIP1 FGD5	1.27e-04	170	127	5	8e1f757ed62218c0fb6525f49d142dd2cd29acf9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TBX21 TMEM216 SLC5A9 ADPRM FRMPD3	1.27e-04	170	127	5	28fb192b21cdc5a77ba4f276694cff852eb2304b
ToppCell	facs-Lung-nan-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 LEPR CEMIP2 CYFIP1 FGD5	1.27e-04	170	127	5	67d7e1da3ebd2d14cb2e67799e94d655027ed5c4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TBX21 TMEM216 SLC5A9 ADPRM FRMPD3	1.27e-04	170	127	5	239cb4b801b2d71a6facb386f2684c0851504151
ToppCell	mild_COVID-19_(asymptomatic)-RBC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	SPAG1 TMEM216 PHF7 LRRC20 ALDH6A1	1.31e-04	171	127	5	78491478ba65bad45238fe114f5251b2adea323d
ToppCell	10x5'-Lung-Myeloid_Dendritic-DC1\|Lung / Manually curated celltypes from each tissue	ENOX1 SERPINF1 RMI2 FAM90A1 PADI2	1.34e-04	172	127	5	243b8bb01cbec5c1bf8802cbf8a6153356b4c384
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 SERPINF1 DCC DNAH9 UNC79	1.38e-04	173	127	5	66f37c1437705734b20601656fa4aa1d92ca30be
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 SERPINF1 DCC DNAH9 UNC79	1.38e-04	173	127	5	649b08a409095592cccf31883be69c754411280d
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENOX1 TBX21 KCNU1 MS4A1 SV2B	1.42e-04	174	127	5	ecdff386d7f0bc57c170a2c1f4deae5ba7e431b5
ToppCell	10x5'-blood-Myeloid_Dendritic\|blood / Manually curated celltypes from each tissue	ENOX1 SERPINF1 FAM90A1 GRHL2 EPHA2	1.46e-04	175	127	5	1c48eec300d5a6d4a810947b995af3b8c0a5a601
ToppCell	COVID-19_Mild-Neu_3\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	DDX55 GRHL2 XRN1 FRMPD3 FCHSD1	1.50e-04	176	127	5	2049767fd591045cfcf5b1071d80798e52843f27
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPFIA2 CEMIP2 ALMS1 SRGAP1 FGD5	1.54e-04	177	127	5	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TBX3 ENOX1 DGKG NCKAP5 ITIH5	1.58e-04	178	127	5	185b44700f06ec58b3c09c80520502166c965fd6
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENOX1 KLHL41 KCNU1 MS4A1 SV2B	1.58e-04	178	127	5	d3cbdec9d75f076e565baca05ede292cca7758a4
ToppCell	390C-Endothelial_cells-Endothelial-E-\|390C / Donor, Lineage, Cell class and subclass (all cells)	TBX3 LEPR FGD5 EML1 UNC79	1.58e-04	178	127	5	804ac3725c1f88e2212172bfb9aa01d97a735621
ToppCell	390C-Endothelial_cells-Endothelial-E\|390C / Donor, Lineage, Cell class and subclass (all cells)	TBX3 LEPR FGD5 EML1 UNC79	1.58e-04	178	127	5	ad6dc4a375664c919bd48c35c48a561fc5a7de8c
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENOX1 KLHL41 KCNU1 MS4A1 SV2B	1.62e-04	179	127	5	4135f9e8cd8494cbc189e5210dded84659643fb8
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Cycling_Myeloid-Mac\|lymph-node_spleen / Manually curated celltypes from each tissue	DMXL2 ITSN1 GTSE1 F13A1 MMP12	1.66e-04	180	127	5	4eea8366cdb82c356325ce88f09ad8b302c17a07
ToppCell	COPD-Myeloid-DC_Mature\|World / Disease state, Lineage and Cell class	ENOX1 SLC22A23 SIPA1L3 AUTS2 CRYBG1	1.70e-04	181	127	5	675603a401d92cf9fdcd44e211ec899fa86a0d49
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	EML4 ASH1L PBX4 CRYBG1 EML1	1.70e-04	181	127	5	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EML4 PBX4 EOMES NTN4 GTF3C1	1.75e-04	182	127	5	f30e5a21b49f30b82e2b6f1fd2daefd805a40083
ToppCell	Control-Epithelial-Basal\|World / Disease state, Lineage and Cell class	SLC22A23 SERPINF1 GRHL2 EPHA2 PTPRQ	1.75e-04	182	127	5	759390dde9b18757f7675d13d44c89d0e32f8d93
ToppCell	COVID-19_Severe-Lymphoid_T/NK-MAIT\|COVID-19_Severe / Disease group, lineage and cell class	EML4 PBX4 EOMES NTN4 GTF3C1	1.75e-04	182	127	5	19045db5c726c06ec6e4feb4311633c8164ddb3c
ToppCell	CTRL-Myeloid-cDC\|Myeloid / Disease state, Lineage and Cell class	SERPINF1 NCKAP5 SRGAP1 AUTS2 MMP12	1.75e-04	182	127	5	ee137574b8f0e684a4a7cb26226877c471cae433
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	EML4 PBX4 EOMES NTN4 GTF3C1	1.75e-04	182	127	5	cccac9f85825f4e310b86e37ee6320769a670501
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DMXL2 FAM90A1 F13A1 SRGAP1 MMP12	1.75e-04	182	127	5	ea39b1b5db185b0cb11dfa2e01f3f972effbd770
ToppCell	Control-Epithelial-Basal\|Control / Disease state, Lineage and Cell class	SLC22A23 SERPINF1 GRHL2 EPHA2 PTPRQ	1.75e-04	182	127	5	caddd0a52f0234ea6a916186ffaf2454cdcd80ee
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EML4 PBX4 EOMES NTN4 GTF3C1	1.75e-04	182	127	5	1444cdc4522a70a40d697ccadf54cf26d327ade0
ToppCell	IPF-Lymphoid-ILC_A\|World / Disease state, Lineage and Cell class	CEMIP2 EOMES MMP25 AUTS2 CRYBG1	1.75e-04	182	127	5	f91bb45baaec76cb3bb26eedbcf0709b2492e93f
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	EML4 PBX4 EOMES NTN4 GTF3C1	1.75e-04	182	127	5	49eced222e8f90c2b59bcc7d56b62c3e703fcce5
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	RBBP6 USP9X ASH1L ADAR XRN1	1.79e-04	183	127	5	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	IPF-Lymphoid-ILC_A\|IPF / Disease state, Lineage and Cell class	CEMIP2 EOMES MMP25 AUTS2 CRYBG1	1.79e-04	183	127	5	49bfeaae13eb236f61a5486ee75c39789936bb8a
ToppCell	Control-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	SIPA1L3 SERPINF1 AUTS2 CRYBG1 PADI2	1.84e-04	184	127	5	c6affa0b12510363258f65e46bf2d47bf4a8e75f
ToppCell	COPD-Lymphoid-B\|COPD / Disease state, Lineage and Cell class	SIPA1L3 CEMIP2 MS4A1 TRPV3 EIF2AK3	1.89e-04	185	127	5	925e79c35c381dd44ec5fb921dca09ce43140135
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CHL1 ENOX1 SLC22A23 NCKAP5 DCC	1.89e-04	185	127	5	1ac6a32cc56d5d819649bdd99518e2ead0eead4c
ToppCell	367C-Myeloid-Dendritic-cDC1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SERPINF1 NCKAP5 G3BP2 PADI6 PADI2	1.98e-04	187	127	5	3748203b62abf51b74dfcfc4f18b3ba831b63a96
ToppCell	Control-Myeloid-DC_Mature\|World / Disease state, Lineage and Cell class	ENOX1 SLC22A23 SIPA1L3 AUTS2 PADI2	1.98e-04	187	127	5	51bfc450e78284796b02317e91830357850b5437
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	EML4 USP9X ASH1L CEMIP2 EIF2AK3	2.03e-04	188	127	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TBX3 LEPR ITIH5 FGD5 EML1	2.03e-04	188	127	5	789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ITSN1 SIPA1L3 GRHL2 EML1 UNC79	2.03e-04	188	127	5	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	Control-Lymphoid-T_Cytotoxic\|World / Disease state, Lineage and Cell class	PBX4 CEMIP2 EOMES AUTS2 CRYBG1	2.08e-04	189	127	5	ee4c1d930534788a7759d92dc8ff9c62e6ee2301
ToppCell	COPD\|World / Disease state, Lineage and Cell class	PBX4 CEMIP2 LGALS3BP ITIH5 CRYBG1	2.08e-04	189	127	5	53577632683686dc493a5a3fdc01887ec5c320f2
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-MAIT\|lymph-node_spleen / Manually curated celltypes from each tissue	EML4 PBX4 EOMES GTF3C1 AUTS2	2.08e-04	189	127	5	afe3a4fe7c10eeeb7064129778d940269c9acbef
ToppCell	Control-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	TBX3 NCKAP5 LEPR CEMIP2 EML1	2.14e-04	190	127	5	7f3f419fffe02934b6f27b697f7a6401072491ed
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CHL1 ENOX1 NCKAP5 DCC AUTS2	2.14e-04	190	127	5	7986586b7c82e91c71102cc8c4d7a689ae63ab4d
ToppCell	IPF-Lymphoid-T_Cytotoxic\|IPF / Disease state, Lineage and Cell class	TBX21 PBX4 CEMIP2 EOMES CRYBG1	2.14e-04	190	127	5	e5d0186bfb416a3eda76ac12b9379650afb6f409
ToppCell	facs-GAT-Fat-3m\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP9X F13A1 CYFIP1 CSGALNACT2 EIF4G2	2.14e-04	190	127	5	1d92be1b41cff59e834a9d28868f554bd1f3e471
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZSWIM8 FASTKD2 DDX55 THOC5 FCHSD1	2.14e-04	190	127	5	3f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCell	Control-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	SIPA1L3 F13A1 SRGAP1 SNX8 PADI2	2.19e-04	191	127	5	11dfd8f38beb294f42710cfbd355cb089e1023c0
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	EML4 EML2 EML3 KCNU1 EML1	3.21e-07	36	118	5	DOID:11723 (implicated_via_orthology)
Disease	non-alcoholic steatohepatitis (is_implicated_in)	SERPINF1 LEPR	2.35e-04	6	118	2	DOID:0080547 (is_implicated_in)
Disease	urinary metabolite measurement	GTSE1 MMP25 ALMS1 TBX10 SGF29 DHTKD1	4.68e-04	245	118	6	EFO_0005116
Disease	level of C-X-C motif chemokine 2 in blood serum	TELO2 CLK2	1.02e-03	12	118	2	OBA_2041207
Disease	alcohol use disorder (implicated_via_orthology)	KCNU1 JMJD7 AUTS2 SMARCD2 UNC79	1.15e-03	195	118	5	DOID:1574 (implicated_via_orthology)
Disease	DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	DMXL2 PTPRQ	1.20e-03	13	118	2	C1846647
Disease	Malignant neoplasm of breast	TBX3 NOA1 DGKG PHF7 ADAR LEPR THOC5 EOMES GUCY2F G3BP2 FGD5 DNAH9	1.26e-03	1074	118	12	C0006142
Disease	Polydactyly	TBX3 USP9X TMEM216 ALMS1	1.27e-03	117	118	4	C0152427
Disease	insulin metabolic clearance rate measurement, glucose homeostasis measurement	COX6C DCC	1.40e-03	14	118	2	EFO_0006830, EFO_0006896
Disease	level of C-X-C motif chemokine 3 in blood serum	TELO2 CLK2	1.61e-03	15	118	2	OBA_2041208
Disease	Congenital total cataract	SIPA1L3 EPHA2	1.83e-03	16	118	2	C0266539
Disease	C-X-C motif chemokine 6 measurement	TELO2 CLK2	1.83e-03	16	118	2	EFO_0008059
Disease	coagulation factor measurement	ENOX1 F13A1	2.87e-03	20	118	2	EFO_0004634
Disease	Familial aplasia of the vermis	TMEM216 ARL13B	2.87e-03	20	118	2	cv:C0431399
Disease	schizophrenia (is_implicated_in)	CHL1 CYFIP1 TRPV3	3.81e-03	78	118	3	DOID:5419 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PVLLPSAAEMKMRSA	AHRR	276	A9YTQ3
EMIITKQGRRMFPFL	EOMES	286	O95936
GRPPKMREAMAEMPF	ASH1L	1351	Q9NR48
SPSPMDAPSVKIRRM	EIF2AK3	686	Q9NZJ5
FMQKRGTPVNRVPIM	ARID3C	126	A6NKF2
AMMERILGPIPSRMI	CLK2	391	P49760
SDLRMLRMSPDTVPK	ALMS1	456	Q8TCU4
PTDRRTGRPFMCMIM	AJM1	941	C9J069
PDKMMLKGRGRVPDR	ADPRM	316	Q3LIE5
MSEMLRHPRISGKPI	ARL13B	111	Q3SXY8
MATPPFRLIRKMFSF	CCDC70	1	Q6NSX1
MRMLVPGRPVKDATP	DMXL2	2421	Q8TDJ6
TGLLQFPPELMFRKM	DHTKD1	231	Q96HY7
FPPELMFRKMRGLSE	DHTKD1	236	Q96HY7
IAMQSGPKPLFRRMS	MS4A1	21	P11836
LRRRVVPPASNMLKM	CRISP1	51	P54107
RFQEKKGPPIQFRMM	RBM41	331	Q96IZ5
RRQMMDPGYPKLITK	MMP12	406	P39900
MRMGPGRKRDFSPVP	PPME1	31	Q9Y570
MAALPGTVPRMMRPA	PAX7	1	P23759
TMGRRIQFPIEMSMP	CYFIP1	631	Q7L576
APKRMRMAAVPVAAA	CYREN	31	Q9BWK5
RMDPGTVATMRKPRC	MMP25	76	Q9NPA2
FLMKPSERVPGATML	ALDH6A1	206	Q02252
RPYFPDLLRMIVMGK	PADI6	611	Q6TGC4
ARRAPRAKLMIPMDA	DCC	1226	P43146
AGSGPKDPMARKMRL	FLII	416	Q13045
GLVEKIRFPMMLPEE	LGALS3BP	341	Q08380
AAFPRLRTIVQKMPM	CHL1	206	O00533
PLDLVSRMKPYARME	IL17B	46	Q9UHF5
TPFTSMKLRGPVPRM	ITIH5	616	Q86UX2
MKRSEKPEGYRQMRP	LATS1	1	O95835
MMARRDPKPGAKRLV	FAM90A1	1	Q86YD7
GDRFMMPAERRLPLS	JMJD7	96	P0C870
TTRVKPFICTMPMRL	CFAP20	111	Q9Y6A4
TTMMPCLLRVGVFRP	CELF2-AS1	111	Q8N7Q2
LARGFALLRMPKMPE	DDX55	451	Q8NHQ9
MRGDKGQKSPRFRMP	FAM90A27P	396	A6NNH2
AVPGLMRERPVSMSF	FGD5	1306	Q6ZNL6
DRTRMMTPFMGISPL	AUTS2	1041	Q8WXX7
KDLAPMKIPRSMFGV	KLHL41	476	O60662
EGRMAELKCRTPPMS	LRRC4	366	Q9HBW1
PGVTRPMKKMFREIR	F13A1	671	P00488
TVVMDIKVPMRGPEF	LEPR	631	P48357
SAPMGLRNFVMPLRA	KCNU1	726	A8MYU2
PLIKFDMLMSPEGAR	LRRC20	166	Q8TCA0
RLMMNFTLGVKPIPF	OR10G3	81	Q8NGC4
MSQMILRTKGPDRLP	PADI2	181	Q9Y2J8
FLEGPFMPPRMKMDR	EIF4G2	351	P78344
ISKSGRMGPAMLRPA	GTSE1	351	Q9NYZ3
PRIKKSTGIPRSFMM	RBBP6	186	Q7Z6E9
VPMRITMDIKAPARP	PTPRQ	1776	Q9UMZ3
FPGFLDMMAPRLRPM	FCHSD1	656	Q86WN1
MRPVSPKEIERMVGA	PBX4	166	Q9BYU1
MMGPPQKSSFFSLRR	DGKG	771	P49619
FRPFGPLMKVKSEMI	CSGALNACT2	251	Q8N6G5
VKRMFRPMEEEFGPV	GRHL2	511	Q6ISB3
MRFAMKSRRGPHVPV	C1orf43	36	Q9BWL3
IRAAPGEFRAIMEMP	ADAR	466	P55265
PPMSRARKEVIMQAF	CAPSL	106	Q8WWF8
DVIRERFGMDPKPEM	FRMPD3	291	Q5JV73
MVMEKPSPLLVGREF	G3BP1	1	Q13283
MVMEKPSPLLVGREF	G3BP2	1	Q9UN86
VMKAINDGFRLPTPM	EPHA2	826	P29317
TFKMRHMPEVPVRIR	GUCY2F	966	P51841
FVKRLAMDPRCKGMP	ITSN1	1356	Q15811
MAPEVLPKPRMRGLL	COX6C	1	P09669
RKPSVVKRMPAMLTG	CEMIP2	1176	Q9UHN6
LRGRPVTMYMPKDQV	EML1	191	O00423
VKMFLRGRPVPMMIP	EML2	21	O95834
VKMFLRGRPITMYIP	EML3	216	Q32P44
MRGRPITMFIPSDVD	EML4	231	Q9HC35
AVMVLMAPRGRVPKD	DNAH9	3191	Q9NYC9
SMRPLKMGGRKVEFP	CRYBG1	1201	Q9Y4K1
MRLPRMFKQEFTGVG	ENOX1	611	Q8TC92
AERAKPEMSRMVPLI	MAP3K19	471	Q56UN5
RMAGFPPLVAEDIML	NOA1	596	Q8NC60
MGREMKKTGTPRPFR	C14orf178	1	Q8N769
KLTPRSPAREMDRMG	PPFIA2	726	O75334
FFMGRLMRRIPEPRI	PLA2G4D	506	Q86XP0
EDRFPGRSTMIMLIP	RETSAT	451	Q6NUM9
MPMKGRFPIRRTLQY	MRPS25	1	P82663
LNMPPLRDGARVLMK	USP9X	1031	Q93008
LRDGARVLMKLMPPD	USP9X	1036	Q93008
RGRPCLVPGKYVMVM	RMI2	91	Q96E14
STFKPMVAPRMGVQL	SRGAP1	1036	Q7Z6B7
TEMVITKSGRRMFPP	TBX3	121	O15119
YRMVPALPPKRMLGA	SNX8	126	Q9Y5X2
MVALKFMPESPRFLL	SV2B	291	Q7L1I2
EIARKLSFPMGRMLF	SYNJ1	706	O43426
MTARGMRPLQSRLPK	NCKAP5	1796	O14513
IVMFKSPRPAAMVLD	NTN4	131	Q9HB63
KEFPQEMLRMGIHIP	PHF7	211	Q9BWX1
VEVDMFLRKPPMASL	SPATA31A6	851	Q5VVP1
IELCPPGKRFMITMV	SLC22A23	306	A1A5C7
MPLTGVEPARMNRKK	TAF2	1	Q6P1X5
FRPVGLMDLFMKRIV	FASTKD2	431	Q9NYY8
EVDMFLRKPPMASLR	SPATA31A7	856	Q8IWB4
RMFPAMRVKITGLDP	TBX15	141	Q96SF7
MMACRDPKPGAKRLV	FAM90A26	1	D6RGX4
TPAMPKMGVRARVAD	SIPA1L3	71	O60292
ILPMFFIVMPGMISR	SLC5A9	326	Q2M3M2
FIVMPGMISRALFPD	SLC5A9	331	Q2M3M2
AGPSFRLMKMARLLA	TELO2	111	Q9Y4R8
DFDLRPSRAPMPMKR	RBMXL2	136	O75526
GMPPTMMDPFRKRLL	SMARCD2	106	Q92925
MAEKRPLRTLGPVMY	C15orf39	1	Q6ZRI6
GRRMFPPFQVKILGM	TBX10	91	O75333
EVDMFLRKPPMASLR	SPATA31A3	856	Q5VYP0
LAKMAEMARRLHPPS	TRIM11	71	Q96F44
VPMMSDPKAVLRYGL	SERPINF1	241	P36955
EVDMFLRKPPMASLR	SPATA31A1	856	Q5TZJ5
EVDMFLRKPPMASLR	SPATA31A5	856	Q5VU36
DSEPPRKTMRRGVLM	SGF29	106	Q96ES7
PKEARMETAVRGMPL	SMRP1	131	Q8NCR6
EMRPRMLPVFFGESI	RFLNA	81	Q6ZTI6
MPRKEFFLQRKPPML	PFAS	636	O15067
LHPFSMKPLLRRAMA	SPAG1	516	Q07617
DLFPLRSMVFMLGTP	XRN1	851	Q8IZH2
MKRQRPDDPMASFLG	SLU7	571	O95391
PLRDGARVLMKLMPP	USP9Y	1036	O00507
KIPLGPSEMSTMRCR	ZSWIM8	891	A7E2V4
KEMVPLMGKRVAAPS	TRPV3	6	Q8NET8
EMAVRGLIRPMNKSP	TRUB2	191	O95900
KMCLRLFRGPSRMKP	THOC5	656	Q13769
LGFLPKMPRLRVVHM	GTF3C1	791	Q12789
ERAAMGRKGIMEPLP	HIVEP2	446	P31629
HKRPVGMLVRMASAP	HIVEP2	1601	P31629
MLPRGLKMAPRGKRL	TMEM216	1	Q9P0N5
EMIITKQGRRMFPFL	TBX21	156	Q9UL17
VLRMLLGKMCAPRYP	TRPM4	506	Q8TD43
AKVFPMRLMLRLGAE	ZFYVE16	1186	Q7Z3T8
DVRFDVMVMCLLPKP	UNC79	566	Q9P2D8
VRKMPGDMSSSPRVR	nan	91	Q9UFV3