Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainMTMR12-like_C

MTMR10 MTMR12

3.97e-063222IPR022587
Domain3-PAP

MTMR10 MTMR12

3.97e-063222PF12578
DomainPPASE_MYOTUBULARIN

MTMR10 MTMR12

1.20e-0414222PS51339
DomainMyotubularin_fam

MTMR10 MTMR12

1.20e-0414222IPR030564
DomainMyotub-related

MTMR10 MTMR12

1.20e-0414222PF06602
DomainMyotubularin-like_Pase_dom

MTMR10 MTMR12

1.20e-0414222IPR010569
DomainC2

FER1L5 PIK3C3 PRKCE

5.37e-04137223SM00239
Domain-

FER1L5 PIK3C3 PRKCE

6.72e-041482232.60.40.150
DomainC2_dom

FER1L5 PIK3C3 PRKCE

9.05e-04164223IPR000008
DomainProt-tyrosine_phosphatase-like

MTMR10 MTMR12

6.00e-0399222IPR029021
DomainHelicase_C

DHX36 CHD9

6.97e-03107222PF00271
DomainHELICc

DHX36 CHD9

6.97e-03107222SM00490
DomainHelicase_C

DHX36 CHD9

7.10e-03108222IPR001650
DomainHELICASE_CTER

DHX36 CHD9

7.22e-03109222PS51194
DomainHELICASE_ATP_BIND_1

DHX36 CHD9

7.22e-03109222PS51192
DomainDEXDc

DHX36 CHD9

7.22e-03109222SM00487
DomainHelicase_ATP-bd

DHX36 CHD9

7.35e-03110222IPR014001
DomainC2

FER1L5 PRKCE

1.03e-02131222PF00168
DomainC2

FER1L5 PRKCE

1.20e-02142222PS50004
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE

PIK3C3 MTMR10 MTMR12

5.41e-0716153M639
PathwayWP_PHOSPHOINOSITIDES_METABOLISM

PIK3C3 MTMR10 MTMR12

1.74e-0549153M40046
PathwayREACTOME_PI_METABOLISM

PIK3C3 MTMR10 MTMR12

8.82e-0584153M676
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE

PIK3C3 MTMR12

1.10e-0415152MM14643
Pubmed

The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia.

UBR5 CSPP1

3.82e-07222229742019
Pubmed

PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease.

MTMR10 MTMR12

3.82e-06522212495846
Pubmed

Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.

UBR5 MTMR10

5.72e-06622232876667
Pubmed

Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.

MTMR10 MTMR12

2.51e-051222216787938
Pubmed

Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.

PIK3C3 PRKCE

7.96e-05212229446795
Pubmed

HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.

PIK3C3 PRKCE

8.76e-052222211154208
Pubmed

Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120.

PIK3C3 PRKCE

1.14e-042522215689238
Pubmed

Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy.

PIK3C3 PRKCE

1.14e-042522217632570
Pubmed

Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.

UBR5 MTMR10 MTMR12

1.57e-0416722325659891
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

DHX36 PIK3C3 CSPP1

5.17e-0425122329778605
Pubmed

Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family.

ANKRD13D IFITM3

5.56e-045522231985874
Pubmed

Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.

UBR5 PIK3C3

6.18e-045822231067491
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

FER1L5 MUC16 CSPP1 ALG11

6.31e-0463822431182584
GeneFamilyMyotubularins|Phosphoinositide phosphatases

MTMR10 MTMR12

7.66e-0515162903
ToppCell356C-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ANKRD13D ICA1L ALG11

3.99e-05136223edfd453c9a650d69d05a5a3ab15f7df56349fa86
ToppCell356C-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ANKRD13D ICA1L ALG11

3.99e-0513622303e4e2353c23ceffde35b2d0aadd15299e3db09f
ToppCelltumor_Lung-Myeloid_cells-Pleural_Mac|Myeloid_cells / Location, Cell class and cell subclass

FER1L5 IFITM3 FSCN3

4.93e-051462238b2d104fdb0fdb09410450c6c651e1edb00cae44
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ANKRD13D MTMR10 ZNF518B

7.74e-05170223ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ILDR2 CSPP1 PRKCE

9.47e-05182223a20017b6a4f9a6a29e090e4dbd7c02ed1495bd50
ToppCellBrain_organoid-organoid_Kanton_Nature|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.

DHX36 CHD9 NKTR

9.94e-05185223857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|343B / Donor, Lineage, Cell class and subclass (all cells)

ILDR2 IFITM3 PRKCE

1.04e-04188223fe7143c36e4a883745862d3c3147cf751b440e46
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|343B / Donor, Lineage, Cell class and subclass (all cells)

ILDR2 IFITM3 PRKCE

1.04e-04188223cbf32b675a7cd0c808d5c9c22dfa7fa79fbe2437
ToppCellCOPD-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

ILDR2 CSPP1 PRKCE

1.04e-041882231aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCellLAM-Endothelial-VasEndo-1|LAM / Condition, Lineage and Cell class

ILDR2 IFITM3 PRKCE

1.06e-04189223454e64b1ee93edebbc1576fbf7c3a6db332fa927
ToppCellCOPD-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

IFITM3 ICA1L PRKCE

1.08e-04190223aece860b5609ad5a8fc920d685f0d0ec71bf9018
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Children_(3_yrs) / Lineage, Cell type, age group and donor

ILDR2 CSPP1 PRKCE

1.09e-04191223f229abf69a1217194f74b0502486907e07dba989
ToppCellIPF-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

GGH ILDR2 PRKCE

1.14e-04194223777ce41c3f22c591e2d81120f189b834e53ffb4b
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ILDR2 IFITM3 PRKCE

1.18e-04196223a53caedd0103bd162b3aee8ab87b4442a5e0338f
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

ANKRD13D CSPP1 NKTR

1.20e-041972230fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCellCOVID-19_Mild|World / Disease group, lineage and cell class

DHX36 IFITM3 NKTR

1.20e-041972235c33454b10023decd2f5ccda9229b6512659711e
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)

DHX36 IFITM3 NKTR

1.22e-0419822344417089b62056269cac38d3134ff209c05b7007
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DHX36 IFITM3 NKTR

1.22e-0419822328ef3fc4c17dcb765537b75917f7db78baa522db
ToppCellGoblet_3|World / shred by cell class for nasal brushing

GGH MUC16 IFITM3

1.23e-041992234229a17a3a6d8855655acc0a1c8704166f8e74c0
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

UBR5 NKTR ZNF518B

1.25e-04200223dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellCOVID-19-COVID-19_Mild|COVID-19 / Disease, condition lineage and cell class

ANKRD13D DHX36 NKTR

1.25e-0420022362c25042086f1afd1102e0720e933c2e476468fd
ToppCellsevere-NK_CD56bright|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ILDR2 IFITM3 CHD9

1.25e-0420022382818ab1796fdd0b8be02b341818897595eed841
Diseaseneurodegenerative disease (implicated_via_orthology)

MTMR10 MTMR12

4.74e-03145212DOID:1289 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
SKNGKNQMVIAFFHP

ALG11

56

Q2TAA5
KTPFQSFLGMAQQHS

ANKRD13D

296

Q6ZTN6
NMQHPGSRKFNTTER

MUC16

13651

Q8WXI7
GTFLFNSPHQRVKQS

MTMR10

501

Q9NXD2
TFFFNSPHQKDTNMG

MTMR12

491

Q9C0I1
MNHTVQTFFSPVNSG

IFITM3

1

Q01628
QVGSQRFSVNMPHKF

PRKCE

231

Q02156
HMQTQSSPFARGNVF

CSPP1

741

Q1MSJ5
ILPFTSMRHQGTQKS

LCA5L

366

O95447
RYNSHQMGQSKQFPL

FBXO38

651

Q6PIJ6
SKNFMNVSGPHRVNV

CHD9

196

Q3L8U1
MNHTVQTFFSPVNSG

nan

1

C9JQL5
PLNFTGGQLHSRMFQ

GGH

161

Q92820
SQFKRGFMQGHVNRQ

DHX36

416

Q9H2U1
FSQPSSQTAFHMQVR

FSCN3

206

Q9NQT6
KHSQMREFGAPQFSN

ICA1L

311

Q8NDH6
QHQTRIKMGNNPFFN

FER1L5

196

A0AVI2
MANRGKHTNGSQFFI

NKTR

111

P30414
STKHGFMQFIQSVPV

PIK3C3

676

Q8NEB9
QSFHQMRSKQFPVSG

ILDR2

351

Q71H61
ISHVGQPMLNFSFNS

THAP4

456

Q8WY91
TGQNHPFFRRSDSMT

UBR5

2016

O95071
IMPNSSVHNNGKSFI

ZNF518B

441

Q9C0D4