Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP49 USP3 USP20 USP47 USP32 USP40	5.14e-08	114	36	6	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP49 USP3 USP20 USP47 USP32 USP40	8.49e-08	124	36	6	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP49 USP3 USP20 USP47 USP32 USP40	1.54e-07	137	36	6	GO:0019783
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP49 USP3 USP20 USP47 USP32 USP40	1.12e-06	192	36	6	GO:0008234
GeneOntologyMolecularFunction	peptidase activity	USP49 APEH PAPPA ADAM11 USP3 USP20 USP47 USP32 USP40	1.75e-06	654	36	9	GO:0008233
GeneOntologyMolecularFunction	histone H2B deubiquitinase activity	USP49 USP3	1.89e-05	4	36	2	GO:0140936
GeneOntologyMolecularFunction	histone deubiquitinase activity	USP49 USP3	8.79e-05	8	36	2	GO:0140934
GeneOntologyMolecularFunction	ubiquinol-cytochrome-c reductase activity	UQCRC1 UQCRFS1P1	8.79e-05	8	36	2	GO:0008121
GeneOntologyMolecularFunction	oxidoreductase activity, acting on diphenols and related substances as donors	UQCRC1 UQCRFS1P1	1.72e-04	11	36	2	GO:0016679
GeneOntologyMolecularFunction	endopeptidase activity	USP49 APEH PAPPA ADAM11 USP20	9.84e-04	430	36	5	GO:0004175
GeneOntologyBiologicalProcess	protein deubiquitination	USP49 USP3 USP20 USP47 USP32 USP40	6.17e-08	125	35	6	GO:0016579
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP49 USP3 USP20 USP47 USP32 USP40	1.43e-07	144	35	6	GO:0070646
GeneOntologyCellularComponent	respiratory chain complex III	UQCRC1 UQCRFS1P1	2.82e-04	15	35	2	GO:0045275
Domain	USP_CS	USP49 USP3 USP20 USP47 USP32 USP40	1.59e-09	66	33	6	IPR018200
Domain	USP_1	USP49 USP3 USP20 USP47 USP32 USP40	2.28e-09	70	33	6	PS00972
Domain	UCH	USP49 USP3 USP20 USP47 USP32 USP40	2.48e-09	71	33	6	PF00443
Domain	USP_2	USP49 USP3 USP20 USP47 USP32 USP40	2.48e-09	71	33	6	PS00973
Domain	USP_3	USP49 USP3 USP20 USP47 USP32 USP40	2.71e-09	72	33	6	PS50235
Domain	USP_dom	USP49 USP3 USP20 USP47 USP32 USP40	2.71e-09	72	33	6	IPR028889
Domain	Peptidase_C19_UCH	USP49 USP3 USP20 USP47 USP32 USP40	2.71e-09	72	33	6	IPR001394
Domain	ZnF_UBP	USP49 USP3 USP20	8.21e-07	11	33	3	SM00290
Domain	zf-UBP	USP49 USP3 USP20	1.81e-06	14	33	3	PF02148
Domain	ZF_UBP	USP49 USP3 USP20	1.81e-06	14	33	3	PS50271
Domain	Znf_UBP	USP49 USP3 USP20	1.81e-06	14	33	3	IPR001607
Domain	DUSP	USP20 USP32	4.52e-05	6	33	2	SM00695
Domain	DUSP	USP20 USP32	4.52e-05	6	33	2	PF06337
Domain	-	USP20 USP32	6.32e-05	7	33	2	3.30.2230.10
Domain	Pept_C19_DUSP	USP20 USP32	6.32e-05	7	33	2	IPR006615
Domain	DUSP	USP20 USP32	6.32e-05	7	33	2	PS51283
Domain	6-blade_b-propeller_TolB-like	APEH ROS1 WDR6	7.24e-05	46	33	3	IPR011042
Domain	-	APEH ROS1	2.15e-03	39	33	2	2.120.10.30
Domain	zf-C4	PPARA NR1D2	2.98e-03	46	33	2	PF00105
Domain	NUCLEAR_REC_DBD_1	PPARA NR1D2	2.98e-03	46	33	2	PS00031
Domain	Znf_hrmn_rcpt	PPARA NR1D2	2.98e-03	46	33	2	IPR001628
Domain	Nuclear_hrmn_rcpt	PPARA NR1D2	2.98e-03	46	33	2	IPR001723
Domain	ZnF_C4	PPARA NR1D2	2.98e-03	46	33	2	SM00399
Domain	NUCLEAR_REC_DBD_2	PPARA NR1D2	2.98e-03	46	33	2	PS51030
Domain	-	PPARA NR1D2	3.11e-03	47	33	2	1.10.565.10
Domain	HOLI	PPARA NR1D2	3.25e-03	48	33	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	PPARA NR1D2	3.25e-03	48	33	2	IPR000536
Domain	Hormone_recep	PPARA NR1D2	3.25e-03	48	33	2	PF00104
Domain	-	PPARA NR1D2	4.55e-03	57	33	2	3.30.50.10
Domain	Znf_NHR/GATA	PPARA NR1D2	4.70e-03	58	33	2	IPR013088
Domain	MetalloPept_cat_dom	PAPPA ADAM11	8.99e-03	81	33	2	IPR024079
Domain	-	PAPPA ADAM11	8.99e-03	81	33	2	3.40.390.10
Domain	-	PAPPA LAMA1	1.22e-02	95	33	2	2.60.120.200
Domain	ZINC_PROTEASE	PAPPA ADAM11	1.29e-02	98	33	2	PS00142
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP3 USP20 USP47 USP32 USP40	2.15e-08	81	36	5	12838346
Pubmed	USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.	USP49 USP3 USP20	2.23e-07	12	36	3	27801882
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP3 USP20 USP47 USP32 USP40	4.27e-07	147	36	5	29576527
Pubmed	Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.	USP49 USP47 USP40	1.78e-06	23	36	3	14715245
Pubmed	Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies.	UQCRC1 UQCRFS1P1	6.24e-06	4	36	2	21278747
Pubmed	Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals.	FCGR2A MUC2	2.18e-05	7	36	2	24072822
Pubmed	Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction.	PAPPA PPARA	2.91e-05	8	36	2	17700210
Pubmed	The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.	ROS1 LAMA1	9.41e-05	14	36	2	9151674
Pubmed	A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.	USP49 USP47	1.08e-04	15	36	2	14576168
Pubmed	Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria.	UQCRC1 UQCRFS1P1	1.08e-04	15	36	2	16120479
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	USP3 USP47 USP32 LAMA1 USP40	1.31e-04	481	36	5	28190767
Pubmed	USP37 is a SNAI1 deubiquitinase.	USP3 USP20	2.83e-04	24	36	2	31911859
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	APEH UQCRC1 TMEM168 CHPF NR1D2 USP47 USP32	3.01e-04	1285	36	7	35914814
Pubmed	Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.	USP20 USP47	3.87e-04	28	36	2	22118674
Pubmed	OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.	USP20 USP40	5.07e-04	32	36	2	33669244
Pubmed	Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon.	MUC2 LAMA1	5.39e-04	33	36	2	16618389
Pubmed	Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.	USP49 USP20	5.39e-04	33	36	2	30323974
Pubmed	Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.	BTBD7 LAMA1	6.78e-04	37	36	2	34323105
Pubmed	Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.	UQCRC1 PPARA	8.33e-04	41	36	2	17276355
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	WDR6 CNOT7	9.59e-04	44	36	2	26471122
Cytoband	22q13.31	PPARA PNPLA5	6.05e-04	46	36	2	22q13.31
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	APEH UQCRC1 WDR6	1.95e-03	316	36	3	chr3p21
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	PPARA PNPLA5 UQCRFS1P1	2.20e-03	330	36	3	chr22q13
Cytoband	3p21.31	APEH WDR6	2.82e-03	100	36	2	3p21.31
Cytoband	Ensembl 112 genes in cytogenetic band chr16q22	TLE7 DPEP2NB	9.11e-03	183	36	2	chr16q22
GeneFamily	Ubiquitin specific peptidases	USP49 USP3 USP20 USP47 USP32 USP40	2.40e-10	56	28	6	366
GeneFamily	Nuclear hormone receptors	PPARA NR1D2	2.60e-03	49	28	2	71
Disease	bitter alcoholic beverage consumption measurement	MAP4K5 PLXNA2 ACSS3	5.27e-04	133	35	3	EFO_0010092
Disease	Crohn Disease	PPARA MUC2	1.62e-03	50	35	2	C0010346
Disease	triacylglycerol 52:2 measurement	USP49 MAP4K5	1.95e-03	55	35	2	EFO_0010414
Disease	response to opioid	SARAF USP32	2.39e-03	61	35	2	EFO_0008541
Disease	cystic fibrosis (is_marker_for)	PPARA MUC2	2.47e-03	62	35	2	DOID:1485 (is_marker_for)
Disease	Non-alcoholic Fatty Liver Disease	PPARA LAMA1	3.14e-03	70	35	2	C0400966
Disease	Malignant Glioma	ROS1 DMXL1	3.14e-03	70	35	2	C0555198
Disease	Nonalcoholic Steatohepatitis	PPARA LAMA1	3.14e-03	70	35	2	C3241937
Disease	mixed gliomas	ROS1 DMXL1	3.14e-03	70	35	2	C0259783
Disease	electrocardiography	ROS1 ADAM11 USP3 USP40	3.47e-03	530	35	4	EFO_0004327
Disease	mucocutaneous lymph node syndrome	FCGR2A PLXNA2	3.69e-03	76	35	2	EFO_0004246
Disease	Glioma	ROS1 DMXL1	4.80e-03	87	35	2	C0017638

Protein segments in the cluster

Peptide	Gene	Start	Entry
HGETYCLVGGYRVHG	DPEP2NB	51	A0A0U1RQF7
HSGDYHCTGNIGYTL	FCGR2A	181	P12318
GTTQHSTGAGDHCYY	ADAM11	121	O75078
RGATHCYDGYIHLSG	CD177	346	Q8N6Q3
CYDGYIHLSGGGLST	CD177	351	Q8N6Q3
YCILHGSHGGGLASV	DMXL1	2136	Q9Y485
GGCHGHYVHGICIYG	GCNT2	336	Q8N0V5
GHYLGAGSSVAVYLG	PLXNA2	976	O75051
CHGTCSIYGSGHYIT	MUC2	856	Q02817
PAVTYIHGSGYCGDG	PAPPA	936	Q13219
IGHYDCTYGGGVHLS	UQCRC1	311	P31930
IYGGHHSAFHCGTVG	OLIG3	151	Q7RTU3
CGHLYGLGSGSSYVQ	CNOT7	256	Q9UIV1
GYGCESKLYSLDHGH	BTBD7	36	Q9P203
SSCSHGGYLHYPGSS	KRTAP13-3	11	Q3SY46
GTRFLYGHYIHGGGC	ERCC6L2	141	Q5T890
YGHYIHGGGCILGDD	ERCC6L2	146	Q5T890
YCGGGSLQDIYHVTG	MAP4K5	96	Q9Y4K4
GYHYGVHACEGCKGF	PPARA	111	Q07869
SGFHYGVHACEGCKG	NR1D2	111	Q14995
AYSPLHGGSGSYSVC	SARAF	306	Q96BY9
GAGYLGAHHVGATEC	PNPLA5	16	Q7Z6Z6
LHGYYGLDSGHGCRP	LAMA1	936	P25391
GSHGGFISCHLIGQY	APEH	586	P13798
VGHSYICYGPLLHGN	ACSS3	346	Q9H6R3
ATGVGCTGDHEGVHY	CHPF	286	Q8IZ52
SSIGYHGSIVGAYAG	ZNF703	311	Q9H7S9
SGSAAGGHYYACIKS	USP47	496	Q96K76
HHGKGFGSGHYTAYC	USP49	606	Q70CQ1
ISGSTHHVYTCGSGY	TLE7	166	A0A1W2PR48
GLNYACLTHSGYGDG	ROS1	2331	P08922
DTYILYYSGHTHGTG	TMEM168	496	Q9H0V1
TCHGGYVYTTGRDGA	WDR6	576	Q9NNW5
HGTAGSGHYIAYCQN	USP20	636	Q9Y2K6
GVGSGHYTAYATHEG	USP3	466	Q9Y6I4
GGYYCPCHGSHYDAS	UQCRFS1P1	241	P0C7P4
IHKGGCYGGHYHVYI	USP40	296	Q9NVE5
SCHSGILGGGHYVTY	USP32	1516	Q8NFA0