Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction1-phosphatidylinositol-4-phosphate 3-kinase activity

PIK3C2A PIK3C2B

2.66e-057232GO:0035005
GeneOntologyMolecularFunctionextracellular matrix structural constituent

MUC5AC LTBP1 VWF TECTA

5.86e-05188234GO:0005201
GeneOntologyMolecularFunction1-phosphatidylinositol-3-kinase activity

PIK3C2A PIK3C2B

6.94e-0511232GO:0016303
GeneOntologyMolecularFunctionphosphatidylinositol kinase activity

PIK3C2A PIK3C2B

4.06e-0426232GO:0052742
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CHD3 CHD4

8.25e-0437232GO:0140658
GeneOntologyMolecularFunctionlipid kinase activity

PIK3C2A PIK3C2B

1.01e-0341232GO:0001727
GeneOntologyMolecularFunctionintegrin binding

TNR CASR VWF

1.03e-03175233GO:0005178
GeneOntologyCellularComponentextracellular matrix

TNR SNED1 MUC5AC LTBP1 VWF TECTA

5.97e-05656236GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

TNR SNED1 MUC5AC LTBP1 VWF TECTA

6.07e-05658236GO:0030312
GeneOntologyCellularComponentNuRD complex

CHD3 CHD4

1.56e-0417232GO:0016581
GeneOntologyCellularComponentCHD-type complex

CHD3 CHD4

1.56e-0417232GO:0090545
GeneOntologyCellularComponentphosphatidylinositol 3-kinase complex

PIK3C2A PIK3C2B

4.62e-0429232GO:0005942
GeneOntologyCellularComponenthistone deacetylase complex

CHD3 CHD4

3.91e-0385232GO:0000118
MousePhenoabnormal circulating phosphate level

PIK3C2A TNR CASR ENPP1 CHD3

1.51e-05260185MP:0001565
MousePhenoabnormal phosphate level

PIK3C2A TNR CASR ENPP1 CHD3

1.56e-05262185MP:0020885
MousePhenocalcinosis

CASR ENPP1

4.36e-058182MP:0003195
MousePhenodecreased circulating mineral level

PCSK5 CASR ENPP1 CHD3 LTBP1

1.06e-04391185MP:0014548
MousePhenoabnormal circulating mineral level

PCSK5 PIK3C2A TNR CASR ENPP1 CHD3 LTBP1

1.32e-04982187MP:0006357
MousePhenodecreased mineral level

PCSK5 CASR ENPP1 CHD3 LTBP1

1.50e-04421185MP:0014536
MousePhenodecreased circulating phosphate level

CASR ENPP1 CHD3

2.16e-0493183MP:0000198
MousePhenoabnormal mineral level

PCSK5 PIK3C2A TNR CASR ENPP1 CHD3 LTBP1

2.21e-041066187MP:0000192
MousePhenodecreased phosphate level

CASR ENPP1 CHD3

2.23e-0494183MP:0014546
MousePhenoabnormal mineral homeostasis

PCSK5 PIK3C2A TNR CASR ENPP1 CHD3 LTBP1

2.35e-041076187MP:0005636
MousePhenonephrocalcinosis

CASR ENPP1

2.93e-0420182MP:0003197
MousePhenoincreased hemoglobin content

AFM LTBP1 VWF

3.84e-04113183MP:0005564
MousePhenoabnormal knee morphology

PCSK5 ENPP1

3.90e-0423182MP:0030881
MousePhenoabnormal ion homeostasis

PCSK5 PIK3C2A TNR CASR ENPP1 CHD3 LTBP1

5.41e-041232187MP:0001765
MousePhenoabnormal coronary artery morphology

ENPP1 LTBP1

6.23e-0429182MP:0004111
MousePhenoabnormal appendicular skeleton morphology

PCSK5 CASR ENPP1 LTBP1 CHD4 AASDH

6.49e-04896186MP:0009250
MousePhenodecreased susceptibility to induced thrombosis

PIK3C2A VWF

6.67e-0430182MP:0031120
MousePhenoincreased susceptibility to otitis media

ENPP1 KIF27

7.12e-0431182MP:0001850
MousePhenovascular ring

PCSK5 LTBP1

9.09e-0435182MP:0010466
MousePhenoincreased width of hypertrophic chondrocyte zone

CASR CHD4

1.13e-0339182MP:0003408
MousePhenoear inflammation

ENPP1 KIF27

1.19e-0340182MP:0001849
MousePhenoabnormal cartilage development

CASR ENPP1 CHD4

1.30e-03172183MP:0000164
MousePhenoabnormal long bone morphology

PCSK5 CASR ENPP1 LTBP1 CHD4

1.32e-03676185MP:0003723
MousePhenoabnormal forelimb morphology

PCSK5 ENPP1 LTBP1

1.53e-03182183MP:0000550
MousePhenoabnormal hemoglobin content

PIK3C2A AFM LTBP1 VWF

1.58e-03408184MP:0005563
DomainTIL

MUC5AC VWF TECTA

3.56e-0712233PF01826
DomainC8

MUC5AC VWF TECTA

3.56e-0712233PF08742
DomainUnchr_dom_Cys-rich

MUC5AC VWF TECTA

4.63e-0713233IPR014853
DomainC8

MUC5AC VWF TECTA

4.63e-0713233SM00832
DomainTIL_dom

MUC5AC VWF TECTA

5.89e-0714233IPR002919
DomainVWFD

MUC5AC VWF TECTA

9.04e-0716233PS51233
DomainVWD

MUC5AC VWF TECTA

9.04e-0716233SM00216
DomainVWF_type-D

MUC5AC VWF TECTA

9.04e-0716233IPR001846
DomainVWD

MUC5AC VWF TECTA

9.04e-0716233PF00094
DomainVWC_out

MUC5AC VWF TECTA

1.56e-0619233SM00215
DomainCHDCT2

CHD3 CHD4

4.35e-063232PF08074
DomainCHDNT

CHD3 CHD4

4.35e-063232PF08073
DomainDUF1086

CHD3 CHD4

4.35e-063232IPR009462
DomainDUF1087

CHD3 CHD4

4.35e-063232IPR009463
DomainDUF1087

CHD3 CHD4

4.35e-063232PF06465
DomainDUF1086

CHD3 CHD4

4.35e-063232PF06461
DomainDUF1087

CHD3 CHD4

4.35e-063232SM01147
DomainDUF1086

CHD3 CHD4

4.35e-063232SM01146
DomainCHD_N

CHD3 CHD4

4.35e-063232IPR012958
DomainCHD_C2

CHD3 CHD4

4.35e-063232IPR012957
DomainEGF

PCSK5 TNR SNED1 LTBP1 TECTA

8.45e-06235235SM00181
DomainEGF-like_dom

PCSK5 TNR SNED1 LTBP1 TECTA

1.12e-05249235IPR000742
DomainVWC

MUC5AC VWF TECTA

1.34e-0538233SM00214
DomainVWFC_2

MUC5AC VWF TECTA

1.34e-0538233PS50184
DomainNIDO_dom

SNED1 TECTA

1.45e-055232IPR003886
DomainNIDO

SNED1 TECTA

1.45e-055232PS51220
DomainNIDO

SNED1 TECTA

1.45e-055232SM00539
DomainNIDO

SNED1 TECTA

1.45e-055232PF06119
DomainVWF_dom

MUC5AC VWF TECTA

1.81e-0542233IPR001007
DomainPI3K_Ras-bd_dom

PIK3C2A PIK3C2B

3.03e-057232IPR000341
DomainPI3K_RBD

PIK3C2A PIK3C2B

3.03e-057232PS51546
DomainPI3K_rbd

PIK3C2A PIK3C2B

3.03e-057232SM00144
DomainPI3K_rbd

PIK3C2A PIK3C2B

3.03e-057232PF00794
DomainPI3K_C2_dom

PIK3C2A PIK3C2B

4.04e-058232IPR002420
DomainPI3K_C2

PIK3C2A PIK3C2B

4.04e-058232PS51547
DomainPI3K_C2

PIK3C2A PIK3C2B

4.04e-058232SM00142
DomainPI3K_C2

PIK3C2A PIK3C2B

4.04e-058232PF00792
DomainPI3Ka

PIK3C2A PIK3C2B

5.19e-059232PF00613
Domain-

PIK3C2A PIK3C2B

5.19e-0592321.25.40.70
DomainPI3Ka

PIK3C2A PIK3C2B

5.19e-059232SM00145
DomainPIK_HELICAL

PIK3C2A PIK3C2B

6.49e-0510232PS51545
DomainPI_Kinase

PIK3C2A PIK3C2B

6.49e-0510232IPR015433
DomainPInositide-3_kin_accessory_dom

PIK3C2A PIK3C2B

6.49e-0510232IPR001263
DomainZinc_finger_PHD-type_CS

KDM2A CHD3 CHD4

6.78e-0565233IPR019786
DomainZnf_PHD-finger

KDM2A CHD3 CHD4

1.21e-0479233IPR019787
DomainPI3/4_kinase_CS

PIK3C2A PIK3C2B

1.51e-0415232IPR018936
DomainPI3Kc

PIK3C2A PIK3C2B

1.72e-0416232SM00146
Domain-

PIK3C2A PIK3C2B

1.72e-04162321.10.1070.11
DomainPHD

KDM2A CHD3 CHD4

1.73e-0489233SM00249
DomainZnf_PHD

KDM2A CHD3 CHD4

1.85e-0491233IPR001965
DomainZF_PHD_2

KDM2A CHD3 CHD4

2.10e-0495233PS50016
DomainZF_PHD_1

KDM2A CHD3 CHD4

2.16e-0496233PS01359
DomainCTCK_1

MUC5AC VWF

2.19e-0418232PS01185
DomainPI3_4_KINASE_1

PIK3C2A PIK3C2B

2.19e-0418232PS00915
DomainPI3_4_KINASE_2

PIK3C2A PIK3C2B

2.19e-0418232PS00916
DomainPI3/4_kinase_cat_dom

PIK3C2A PIK3C2B

2.19e-0418232IPR000403
DomainPI3_PI4_kinase

PIK3C2A PIK3C2B

2.19e-0418232PF00454
DomainPI3_4_KINASE_3

PIK3C2A PIK3C2B

2.19e-0418232PS50290
DomainCT

MUC5AC VWF

3.30e-0422232SM00041
DomainChromo_domain

CHD3 CHD4

3.94e-0424232IPR023780
DomainCys_knot_C

MUC5AC VWF

4.28e-0425232IPR006207
DomainCTCK_2

MUC5AC VWF

4.28e-0425232PS01225
DomainChromo

CHD3 CHD4

4.63e-0426232PF00385
DomainEGF

SNED1 LTBP1 TECTA

4.81e-04126233PF00008
DomainCHROMO_2

CHD3 CHD4

5.38e-0428232PS50013
DomainCHROMO_1

CHD3 CHD4

5.38e-0428232PS00598
DomainVWC

MUC5AC VWF

5.38e-0428232PF00093
DomainSNF2_N

CHD3 CHD4

7.04e-0432232PF00176
DomainSNF2_N

CHD3 CHD4

7.04e-0432232IPR000330
DomainChromodomain-like

CHD3 CHD4

7.04e-0432232IPR016197
DomainCHROMO

CHD3 CHD4

7.48e-0433232SM00298
DomainChromo/shadow_dom

CHD3 CHD4

7.48e-0433232IPR000953
DomainZnf_FYVE_PHD

KDM2A CHD3 CHD4

7.54e-04147233IPR011011
DomainDNA/RNA_helicase_DEAH_CS

CHD3 CHD4

8.42e-0435232IPR002464
DomainVWFC_1

MUC5AC VWF

8.91e-0436232PS01208
DomainDEAH_ATP_HELICASE

CHD3 CHD4

9.93e-0438232PS00690
DomainPX

PIK3C2A PIK3C2B

1.33e-0344232SM00312
DomainPX

PIK3C2A PIK3C2B

1.65e-0349232PF00787
DomainPX

PIK3C2A PIK3C2B

1.71e-0350232PS50195
Domain-

PIK3C2A PIK3C2B

1.78e-03512323.30.1520.10
DomainPhox

PIK3C2A PIK3C2B

1.85e-0352232IPR001683
DomainHMG_box_dom

CHD3 CHD4

2.88e-0365232IPR009071
DomainEGF_3

TNR SNED1 LTBP1

2.89e-03235233PS50026
DomainEGF_1

TNR SNED1 LTBP1

3.64e-03255233PS00022
PathwayREACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION

CHD3 CHD4

6.57e-0427202MM15537
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION

CHD3 CHD4

7.59e-0429202MM15340
PathwayWP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING

PIK3C2A TNR PIK3C2B VWF

7.63e-04302204M39719
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION

CHD3 CHD4

8.12e-0430202M27637
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_BROWN_AND_BEIGE_ADIPOCYTE_DIFFERENTIATION

CHD3 CHD4

8.68e-0431202M48258
PathwayWP_FOCAL_ADHESION_PI3KAKTMTOR_SIGNALING_PATHWAY

PIK3C2A TNR PIK3C2B VWF

1.01e-03326204MM15917
PathwayWP_EFFECT_OF_PROGERIN_ON_GENES_INVOLVED_IN_PROGERIA

CHD3 CHD4

1.24e-0337202M39756
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KDM2A CHD3 CHD4

1.84e-03175203MM14941
PathwayWP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY

PIK3C2A PIK3C2B

1.91e-0346202M48317
PathwayREACTOME_RNA_POLYMERASE_I_TRANSCRIPTION

CHD3 CHD4

1.99e-0347202MM15428
PathwayREACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_INITIATION

CHD3 CHD4

1.99e-0347202M1095
PathwayWP_PHOSPHOINOSITIDES_METABOLISM

PIK3C2A PIK3C2B

2.16e-0349202M40046
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE

PIK3C2A PIK3C2B

2.25e-0350202MM14641
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE

PIK3C2A PIK3C2B

2.52e-0353202M662
PathwayKEGG_INOSITOL_PHOSPHATE_METABOLISM

PIK3C2A PIK3C2B

2.62e-0354202M3896
PathwayREACTOME_HDACS_DEACETYLATE_HISTONES

CHD3 CHD4

2.71e-0355202MM14932
Pubmed

Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen.

CHD3 CHD4

4.56e-0722427560064
Pubmed

The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells.

PIK3C2A PIK3C2B

4.56e-07224230374841
Pubmed

Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice.

PIK3C2A PIK3C2B

4.56e-07224232192434
Pubmed

Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation.

PIK3C2A PIK3C2B

4.56e-07224214563213
Pubmed

Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development.

CHD3 CHD4

4.56e-07224235568926
Pubmed

The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation.

CHD3 CHD4

4.56e-0722427575689
Pubmed

Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen.

CHD3 CHD4

4.56e-0722428843877
Pubmed

Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis.

PIK3C2A PIK3C2B

1.37e-06324223320105
Pubmed

Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β.

PIK3C2A PIK3C2B

1.37e-06324222128329
Pubmed

The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development.

CHD3 CHD4

1.37e-06324232658897
Pubmed

The molecular mechanisms mediating class II PI 3-kinase function in cell physiology.

PIK3C2A PIK3C2B

1.37e-06324233387369
Pubmed

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

PIK3C2A PIK3C2B

1.37e-06324225779105
Pubmed

Characterization of the CHD family of proteins.

CHD3 CHD4

2.74e-0642429326634
Pubmed

Class II PI3Ks α and β Are Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice.

PIK3C2A PIK3C2B

2.74e-06424230476019
Pubmed

Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.

PIK3C2A PIK3C2B

2.74e-06424224098492
Pubmed

NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex.

CHD3 CHD4

2.74e-06424216574654
Pubmed

Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.

PIK3C2A PIK3C2B

4.56e-06524210805725
Pubmed

Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer.

PIK3C2A PIK3C2B

4.56e-06524220197460
Pubmed

Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.

CHD3 CHD4

6.83e-06624217626165
Pubmed

Mammalian chromodomain proteins: their role in genome organisation and expression.

CHD3 CHD4

1.27e-05824210655032
Pubmed

The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.

PIK3C2A PIK3C2B

2.05e-05102428636073
Pubmed

Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.

PIK3C2A PIK3C2B

2.05e-05102428798481
Pubmed

Expression of HIV-1 nef decreases basal phosphatidyl-inositol 3-kinase activity.

PIK3C2A PIK3C2B

2.05e-05102429247029
Pubmed

HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.

PIK3C2A PIK3C2B

2.50e-05112429708406
Pubmed

HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line.

PIK3C2A PIK3C2B

2.50e-051124210985305
Pubmed

Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells.

PIK3C2A PIK3C2B

2.50e-051124212584329
Pubmed

Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity.

PIK3C2A PIK3C2B

2.50e-05112429808187
Pubmed

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.

CHD3 CHD4

2.50e-051124210204490
Pubmed

HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.

PIK3C2A PIK3C2B

2.50e-051124216081599
Pubmed

NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.

CHD3 CHD4

3.00e-051224222560079
Pubmed

HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.

PIK3C2A PIK3C2B

3.00e-051224210208934
Pubmed

Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.

PIK3C2A PIK3C2B

3.00e-051224214602571
Pubmed

Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells.

PIK3C2A PIK3C2B

3.00e-051224216514418
Pubmed

Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.

PIK3C2A PIK3C2B

3.00e-051224212077252
Pubmed

Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.

PIK3C2A PIK3C2B

3.00e-05122429341793
Pubmed

NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.

CHD3 CHD4

3.00e-05122429885572
Pubmed

Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.

PIK3C2A PIK3C2B

3.00e-051224212551992
Pubmed

HIV-1 Nef in macrophage-mediated disease pathogenesis.

PIK3C2A PIK3C2B

3.54e-051324223215766
Pubmed

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer.

CHD3 CHD4

3.54e-051324219703393
Pubmed

Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.

PIK3C2A PIK3C2B

3.54e-05132429394803
Pubmed

The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny.

CHD3 CHD4

4.13e-051424217360773
Pubmed

MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

CHD3 CHD4

4.13e-051424216428440
Pubmed

Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.

PIK3C2A PIK3C2B

4.13e-051424217157319
Pubmed

NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.

CHD3 CHD4

4.13e-051424225150861
Pubmed

Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA.

CHD3 CHD4

4.13e-051424220585571
Pubmed

HIV Nef enhances Tat-mediated viral transcription through a hnRNP-K-nucleated signaling complex.

PIK3C2A PIK3C2B

4.77e-051524218854243
Pubmed

Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.

CHD3 CHD4

4.77e-05152429804427
Pubmed

DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.

CHD3 CHD4

4.77e-051524235695185
Pubmed

NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development.

CHD3 CHD4

4.77e-051524219927129
Pubmed

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation.

CHD3 CHD4

5.44e-051624230760870
Pubmed

HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.

PIK3C2A PIK3C2B

5.44e-051624216524887
Pubmed

p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis.

CHD3 CHD4

5.44e-051624221930775
Pubmed

Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders.

PIK3C2A PIK3C2B

5.44e-051624220818790
Pubmed

HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway.

PIK3C2A PIK3C2B

5.44e-051624211289809
Pubmed

Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice.

PIK3C2A PIK3C2B

5.44e-051624220019835
Pubmed

Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation.

PIK3C2A PIK3C2B

5.44e-051624221029719
Pubmed

Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes.

PIK3C2A PIK3C2B

6.17e-051724223251686
Pubmed

Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.

PIK3C2A PIK3C2B

6.17e-051724212960231
Pubmed

Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages.

PIK3C2A PIK3C2B

6.17e-051724218453587
Pubmed

A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.

CHD3 CHD4

6.17e-051724227806305
Pubmed

HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway.

PIK3C2A PIK3C2B

6.94e-051824212526811
Pubmed

Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development.

CHD3 CHD4

6.94e-051824223201013
Pubmed

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.

CHD3 CHD4

6.94e-051824210444591
Pubmed

The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.

CHD3 CHD4

6.94e-05182429790534
Pubmed

A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.

CHD3 CHD4

6.94e-051824212493763
Pubmed

LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis.

CHD3 CHD4

6.94e-051824219497860
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

PCSK5 LTBP1 VWF

7.31e-0511824321078624
Pubmed

HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: effect on T cells proliferation.

PIK3C2A PIK3C2B

7.75e-051924224073214
Pubmed

Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.

PIK3C2A PIK3C2B

9.51e-05212429446795
Pubmed

Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality.

CASR ENPP1

9.51e-052124223895994
Pubmed

HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.

PIK3C2A PIK3C2B

1.05e-042224211994280
Pubmed

HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.

PIK3C2A PIK3C2B

1.05e-042224211154208
Pubmed

HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3β signaling pathway.

PIK3C2A PIK3C2B

1.14e-042324223301033
Pubmed

Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia.

PIK3C2A PIK3C2B

1.14e-042324219047410
Pubmed

Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120.

PIK3C2A PIK3C2B

1.36e-042524215689238
Pubmed

Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy.

PIK3C2A PIK3C2B

1.36e-042524217632570
Pubmed

HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.

PIK3C2A PIK3C2B

1.59e-042724211156964
Pubmed

Characterization of long cDNA clones from human adult spleen.

KDM2A SEMA3G

2.38e-043324211214971
Pubmed

Identification of the BRD1 interaction network and its impact on mental disorder risk.

CHD3 CHD4

2.68e-043524227142060
Pubmed

Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

CHD3 CHD4

3.16e-043824233283408
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

PIK3C2A KDM2A CHD4 VWF

3.49e-0449724423414517
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

PIK3C2A CHD3 CHD4

3.57e-0420224324639526
Pubmed

PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex.

CHD3 CHD4

3.68e-044124222720776
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

ARHGAP45 CHD3 LTBP1 CHD4

4.54e-0453324430554943
Pubmed

Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

AFM VWF

4.84e-044724214760718
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

PCSK5 LTBP1 VWF

6.49e-0424824324006456
Pubmed

Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).

KDM2A CHD3

6.63e-045524227114453
Pubmed

Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.

CHD3 CHD4

6.87e-045624226919559
Cytoband2q37.3

RTP5 SNED1

7.48e-04772422q37.3
CytobandEnsembl 112 genes in cytogenetic band chr9q21

PCSK5 KIF27

4.85e-03199242chr9q21
CytobandEnsembl 112 genes in cytogenetic band chr2q37

RTP5 SNED1

6.20e-03226242chr2q37
CytobandEnsembl 112 genes in cytogenetic band chr12p13

CHD4 VWF

1.46e-02353242chr12p13
GeneFamilyPhosphatidylinositol 3-kinase subunits

PIK3C2A PIK3C2B

2.92e-058192831
GeneFamilyPHD finger proteins|NuRD complex

CHD3 CHD4

6.86e-05121921305
GeneFamilyPHD finger proteins

KDM2A CHD3 CHD4

1.09e-049019388
GeneFamilyFibronectin type III domain containing

TNR SNED1

1.21e-02160192555
CoexpressionNABA_ECM_GLYCOPROTEINS

TNR SNED1 LTBP1 VWF TECTA

5.90e-07191235MM17059
CoexpressionNABA_ECM_GLYCOPROTEINS

TNR SNED1 LTBP1 VWF TECTA

6.70e-07196235M3008
CoexpressionNABA_MATRISOME

PCSK5 TNR SNED1 MUC5AC LTBP1 SEMA3G VWF TECTA

1.36e-061008238MM17056
CoexpressionNABA_MATRISOME

PCSK5 TNR SNED1 MUC5AC LTBP1 SEMA3G VWF TECTA

1.56e-061026238M5889
CoexpressionHE_LIM_SUN_FETAL_LUNG_C3_GRIA2_POS_ARTERIAL_ENDO_CELL

PCSK5 PIK3C2B LTBP1 SEMA3G

2.92e-06115234M45752
CoexpressionNABA_CORE_MATRISOME

TNR SNED1 LTBP1 VWF TECTA

3.23e-06270235MM17057
CoexpressionNABA_CORE_MATRISOME

TNR SNED1 LTBP1 VWF TECTA

3.53e-06275235M5884
CoexpressionTRAVAGLINI_LUNG_ARTERY_CELL

PCSK5 PIK3C2B LTBP1 SEMA3G

4.90e-06131234M41662
CoexpressionGSE28737_BCL6_HET_VS_BCL6_KO_FOLLICULAR_BCELL_UP

PCNX3 SNED1 CHD4 VWF

2.60e-05200234M9380
CoexpressionHE_LIM_SUN_FETAL_LUNG_C3_ARTERIAL_ENDOTHELIAL_CELL

PCSK5 PIK3C2B LTBP1 SEMA3G

1.04e-04286234M45746
CoexpressionOCONNOR_PBMC_MENVEO_ACWYVAX_AGE_30_70YO_7DY_AFTER_SECOND_DOSE_VS_7DY_AFTER_FIRST_DOSE_UP

PCNX3 KDM2A CHD4

2.76e-04146233M41190
ToppCellControl-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

PCSK5 PIK3C2B LTBP1 SEMA3G VWF

5.35e-081922457e89b9125e8b85f6be85eeccef5c8644647ab0e1
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 PIK3C2B LTBP1 SEMA3G VWF

5.92e-08196245cf7f384c1771274e766bab03ecc3dfbd13f2df60
ToppCelldistal-2-Endothelial-Artery|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PCSK5 PIK3C2B LTBP1 SEMA3G VWF

6.39e-08199245fa8aaf7a90699e41a7a4cee5614f8c9248110327
ToppCellParenchyma_COVID-19-Endothelial-TX-Artery|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

PCSK5 PIK3C2B LTBP1 SEMA3G VWF

6.55e-0820024534b279804475ea58fbb052b96f44128c082627a9
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Artery|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PCSK5 PIK3C2B LTBP1 SEMA3G VWF

6.55e-082002458552cc7a439449b30b59760c3e8667217b9852b5
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Artery-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PCSK5 PIK3C2B LTBP1 SEMA3G VWF

6.55e-0820024545c08f1befe78553bbadcc2fcffb6138306638f3
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PIK3C2B FAM153B SEMA3G VWF

1.44e-06157244275a4c6fef1fff8da2bdc48e3924ad05c5e5cfc8
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PCSK5 PIK3C2B SEMA3G VWF

1.63e-0616224425bb1b9709f960fdf90faff56e874f52a8f5d17e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3C2A PIK3C2B SNED1 SEMA3G

1.93e-06169244987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-arterial_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PCSK5 PIK3C2B SEMA3G VWF

2.11e-061732443a9e9a09b3eeb37cbe56d650e112a8398879477f
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PCSK5 PIK3C2B SEMA3G VWF

2.31e-061772445ff8dcfb030312126695d53a026d2e104a401b83
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PCSK5 PIK3C2A PIK3C2B SEMA3G

2.42e-061792441ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

PCSK5 PIK3C2B SEMA3G VWF

2.42e-061792442a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 PIK3C2B SEMA3G VWF

2.42e-06179244d2db9e70b780643f1e004c41a70464d0abe26088
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 PIK3C2B SEMA3G VWF

2.53e-061812444ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCellEndothelial-E|World / shred on cell class and cell subclass (v4)

PCSK5 LTBP1 SEMA3G VWF

2.70e-06184244b4c561924c508536fd2112e91e32176b95fdf63a
ToppCellCOVID-19-Endothelial_cells-Arterial_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

PIK3C2B LTBP1 SEMA3G VWF

2.70e-061842440f19494789f38ab1a420545e15e748ca7eb345c3
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 PIK3C2B LTBP1 VWF

2.82e-061862442d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

PCSK5 PIK3C2B SEMA3G VWF

2.88e-0618724440ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellCOVID-19-lung-Artery_EC|lung / Disease (COVID-19 only), tissue and cell type

PIK3C2B LTBP1 SEMA3G VWF

2.94e-06188244eecd7482b3c97d7f49993cb17edfab30c61232fc
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 PIK3C2B SEMA3G VWF

3.00e-061892446463890d8dbee4bc198f91628a5f784970de786a
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 PIK3C2B SEMA3G VWF

3.00e-061892449da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 PIK3C2B LTBP1 VWF

3.06e-06190244aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCellEndothelial-A-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

CASR LTBP1 SEMA3G VWF

3.13e-06191244f702dfe88a9b04091dae87df61b2b4f43525f86a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 PIK3C2B SEMA3G VWF

3.13e-06191244b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 LTBP1 SEMA3G VWF

3.13e-06191244b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 PIK3C2B LTBP1 VWF

3.13e-061912444b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PCSK5 PIK3C2B LTBP1 SEMA3G

3.19e-06192244aedddccacf60e884af044cefba6c64ca10ac97d2
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 PIK3C2B SEMA3G VWF

3.19e-06192244285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PCSK5 PIK3C2B LTBP1 SEMA3G

3.19e-06192244389d5e6d0689371bfe1d0b06e92e0e6e5573567b
ToppCellIPF-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

PCSK5 PIK3C2B LTBP1 SEMA3G

3.19e-06192244e911e286da26202853f9650ba3cdefe5a5c9b585
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 PIK3C2B SEMA3G VWF

3.19e-0619224456b021c297a21dff357531f21e2464f85186106d
ToppCellIPF-Endothelial-VE_Arterial|World / Disease state, Lineage and Cell class

PIK3C2B LTBP1 SEMA3G VWF

3.26e-0619324470a9aadda83a97e06e9bc2d1327ce60dd3c58767
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3C2B SNED1 LTBP1 SEMA3G

3.26e-061932442e72309607902dabe3218888b22a77fe941f3570
ToppCellIPF-Endothelial-VE_Arterial|IPF / Disease state, Lineage and Cell class

PIK3C2B LTBP1 SEMA3G VWF

3.26e-06193244bf83b1fe9d38408f30eee4eb634341c04ef82791
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 LTBP1 SEMA3G VWF

3.26e-0619324458c590dd6f21bc7ae58ae1729dd574c0f1069592
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 PIK3C2B SEMA3G VWF

3.40e-061952446bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3C2B SNED1 SEMA3G VWF

3.40e-0619524477e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3C2B SNED1 SEMA3G VWF

3.47e-061962448ad8efb631164b46f0c082572270188e5ead20bf
ToppCell(6)_Endothelial_cells-(6)_Endothelial-B_(Artery)|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

PCSK5 PIK3C2B LTBP1 SEMA3G

3.47e-06196244f540cf17b4405a6dd38d2b6123e6541d0aac889e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3C2B SNED1 SEMA3G VWF

3.47e-061962449606ea7e42f707e69ea891b3521037613b9675f5
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3C2A PIK3C2B SEMA3G VWF

3.47e-06196244adee900dcd16dbaba15c58bdcace09ba20214950
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3C2A PIK3C2B SEMA3G VWF

3.47e-0619624422767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCellcellseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PIK3C2B LTBP1 SEMA3G VWF

3.54e-0619724456afed433887cb2766eb30f22aec195148db33ab
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PIK3C2B ENPP1 SEMA3G VWF

3.61e-0619824488b4662be9cc933a402c52673fa5e00fa979c0db
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 LTBP1 SEMA3G VWF

3.61e-061982445e781583908c4ee107d986904a646a7c6b8e3591
ToppCellproximal-Endothelial-Artery|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TEX29 PIK3C2B SEMA3G VWF

3.61e-061982440e5572298676b6c2a2b1a77967574020b664aebd
ToppCellproximal-3-Endothelial-Artery|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TEX29 PIK3C2B SEMA3G VWF

3.61e-06198244946f72b594d22ae7b8e4c22483814c284cb43eea
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PIK3C2B LTBP1 SEMA3G VWF

3.61e-0619824455378e15360f867c9500b03293814965562ae55d
ToppCellproximal-Endothelial-Artery-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TEX29 PIK3C2B SEMA3G VWF

3.61e-06198244a56b80bdc824e4cc60366f273fb616cd0efec456
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 PIK3C2B SEMA3G VWF

3.68e-06199244a3ec743b978ba8fdf1677b4971b5731f50ddd30f
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TEX29 PIK3C2B SEMA3G VWF

3.68e-061992446a2943a23fdd2ec814662db7c21a0d6804a6cbbc
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 PIK3C2B SEMA3G VWF

3.68e-061992449b02acae6325b0ac9642438a4431285ff396e5fe
ToppCelldistal-Endothelial-Artery|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PCSK5 PIK3C2B SEMA3G VWF

3.68e-06199244b6e9aaac047d4b64b9d97f5e174e89a424d8b36d
ToppCelldistal-Endothelial-Artery-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PCSK5 PIK3C2B SEMA3G VWF

3.68e-061992443788f3218356aaaa10684e48d63757037f8a3a3c
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PIK3C2B LTBP1 SEMA3G VWF

3.76e-06200244ac6b8bc9998d303f788511b8f111e682ea9f3df8
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / Treatment groups by lineage, cell group, cell type

PCSK5 PIK3C2B LTBP1 VWF

3.76e-06200244b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PCSK5 PIK3C2B LTBP1 VWF

3.76e-06200244b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PCSK5 PIK3C2B LTBP1 VWF

3.76e-0620024477ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCellControl_saline-Endothelial-Endothelial-Artery|Control_saline / Treatment groups by lineage, cell group, cell type

PCSK5 PIK3C2B LTBP1 VWF

3.76e-0620024465b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCellLPS_IL1RA-Endothelial-Endothelial-Artery|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PCSK5 PIK3C2B LTBP1 VWF

3.76e-06200244ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PIK3C2B SEMA3G VWF

7.12e-051512433b4c57bad61e17a573e6f8dc6b917fba5fd56c43
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 SEMA3G VWF

7.55e-05154243e51a5114f0ec38f997f5b8bbf3a7770f98595474
ToppCell10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3|bone_marrow / Manually curated celltypes from each tissue

TNR ENPP1 SPAG1

7.70e-0515524383430a64c2cb5ad29caa3dacba76c28dd204ac40
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PCSK5 TNR SNED1

7.99e-05157243b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PCNX3 ENPP1 AASDH

8.46e-051602438374ae912337947b2cc8d17d5840f306361fe1ff
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PIK3C2B SEMA3G VWF

9.10e-051642433cd80e6275f0f9b5667912139d15ebf5e6b17f2f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3C2A PIK3C2B VWF

9.26e-05165243a74751e0ec857aa974bec04ccc747c004a8f6e01
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 SEMA3G VWF

9.43e-051662437a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 SEMA3G VWF

9.43e-05166243bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCell10x5'-Liver-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated|Liver / Manually curated celltypes from each tissue

SNED1 FAM153B AASDH

9.43e-051662439afa33b5ad27dc33576be592f9b22d8161366838
ToppCellP15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCNX3 ARHGAP45 PIK3C2B

9.60e-051672435c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)-|356C / Donor, Lineage, Cell class and subclass (all cells)

PIK3C2B SEMA3G VWF

9.94e-05169243337be3bf485b54afad86e256cb0c4c1d0c2a9a2a
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)|356C / Donor, Lineage, Cell class and subclass (all cells)

PIK3C2B SEMA3G VWF

9.94e-05169243605cc2638271803cf1d972ab3fa8f13f89666376
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PIK3C2B SEMA3G VWF

1.05e-04172243de9b11ab109d04937186c09772cec9105a935f95
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SNED1 LTBP1 TECTA

1.05e-04172243e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCellE15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 SEMA3G VWF

1.07e-04173243b0ff9808e38cb64a734ced498cd0546728746cd5
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)|368C / Donor, Lineage, Cell class and subclass (all cells)

PIK3C2B SEMA3G VWF

1.07e-0417324322200fe74e33e2beae0eed289ca8476bbc0b1b2d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP45 TNR SNED1

1.07e-04173243afa6bb19df52541d8d17cbfac9cbdd18a5f3632d
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)-|368C / Donor, Lineage, Cell class and subclass (all cells)

PIK3C2B SEMA3G VWF

1.07e-04173243ec88e871b49331fca59bc610a8ae58e2d5e76bc1
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 SEMA3G VWF

1.08e-0417424340bb87d219aafab0357ab0d797efd38085fc0312
ToppCell(6)_Endothelial_cells-(6)_Endothelial-E|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

ENPP1 SEMA3G VWF

1.08e-041742434a1b67ce5ea353b3f81f59fa57da07668146afca
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 PIK3C2B SEMA3G

1.08e-0417424318ab52d8bbca0507fee220e0c4fc765fc47dda34
ToppCelldroplet-Kidney-nan-3m-Lymphocytic-B_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP45 PIK3C2B SPAG1

1.08e-04174243ce9bdd02dc8eb45ba9c1481619c0089b465e6442
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D175|Adult / Lineage, Cell type, age group and donor

PIK3C2B SEMA3G VWF

1.10e-041752430a65ddfa8c2e8efb5b5338cf07661cb78157a23c
ToppCell(0)_Normal/No_Treatment-(3)_LEPR+_perivascular_cells|World / Stress and Cell class

SNED1 ENPP1 LTBP1

1.12e-04176243ce2c32b5ce0da848eb4da35ce4d215cdf74d9113
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 SEMA3G VWF

1.12e-0417624377516048aefbe1f48e825052756df0c310c1c486
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 SEMA3G VWF

1.12e-0417624396779273b94345250cf53ba671203345b43d9e00
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 SEMA3G VWF

1.12e-0417624327e6b3ae41068d6cfdda3d46da7df2a27567140e
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 SEMA3G VWF

1.12e-04176243d6a5470af9592f34a741265f2ea9651c05c3add3
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNR SEMA3G VWF

1.14e-0417724316197068260fc062bf8b730a51a199887ea580b9
ToppCell367C-Endothelial_cells-Endothelial-B_(Artery)|367C / Donor, Lineage, Cell class and subclass (all cells)

PIK3C2B SEMA3G VWF

1.16e-04178243e1e96a0e3ff718ebf676a982bc63e8ced6984059
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3C2B SEMA3G VWF

1.16e-041782435f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

PIK3C2B SEMA3G VWF

1.16e-04178243c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCell367C-Endothelial_cells-Endothelial-B_(Artery)-|367C / Donor, Lineage, Cell class and subclass (all cells)

PIK3C2B SEMA3G VWF

1.16e-04178243363e8b23b3834692a8a79e5fdc7b43bd3a4dab5e
ToppCelldroplet-Kidney-nan-21m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LTBP1 SEMA3G VWF

1.18e-04179243b7281160c84dd053a2981c9c76ea6cc6d2592cd5
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 SEMA3G VWF

1.20e-0418024367c5068b660cd5e727a665cefe3bd5f8ae887221
ToppCellEndothelial-A-HP_01|World / lung cells shred on cell class, cell subclass, sample id

TNR SEMA3G VWF

1.20e-041802434c3376169770ee9f9283daae44c17f35e46bfd19
ToppCelldroplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 PIK3C2B VWF

1.22e-04181243136b0c60680068838d184d32aa99d7bea8718dbc
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 SEMA3G VWF

1.22e-041812434d7793026373cbcf04b15c77f95f1025d07d4c00
Diseaseeosinophil percentage of leukocytes

ARHGAP45 PIK3C2B MUC5AC CASR KIF27

1.48e-04746215EFO_0007991
Diseaseend stage renal disease (is_implicated_in)

ENPP1 VWF

3.89e-0441212DOID:783 (is_implicated_in)
Diseaseend stage renal disease (is_marker_for)

CASR VWF

4.90e-0446212DOID:783 (is_marker_for)
Diseasepulmonary fibrosis (biomarker_via_orthology)

MUC5AC VWF

5.79e-0450212DOID:3770 (biomarker_via_orthology)
Diseasemean platelet volume

PCNX3 ARHGAP45 CASR LTBP1 VWF

6.27e-041020215EFO_0004584
DiseasePROSTATE CANCER, HEREDITARY, 1

KDM2A CHD3

8.33e-0460212C4722327
Diseaseinterstitial lung disease

MUC5AC SPAG1

1.04e-0367212EFO_0004244
DiseaseProstate cancer, familial

KDM2A CHD3

1.10e-0369212C2931456

Protein segments in the cluster

PeptideGeneStartEntry
YDGCCEGDVVQCIRD

AFM

266

P43652
CCFECVECPDGEYSD

CASR

561

P41180
CCSQYICIGCVDGNL

AASDH

946

Q4L235
VYFQGAECEECCLAC

ARHGAP45

721

Q92619
GECLGYQCCVEEAFT

KIF27

406

Q86VH2
AITEGVEEDEGCCCC

PCNX3

1416

Q9H6A9
DYEECVPCEEGCLGC

PCSK5

1031

Q92824
CVRVQEGYTCDCFDG

LTBP1

1636

Q14766
CAGCCVATYVLGICD

PIK3C2A

1236

O00443
CVELGNCCLDYQETC

ENPP1

126

P22413
CQSCLCTERGVECTY

MUC5AC

1256

P98088
CAGCCVATYVLGICD

PIK3C2B

1181

O00750
ACVQGECGVCHYCRD

KDM2A

576

Q9Y2K7
YCEVCQQGGEIILCD

CHD3

381

Q12873
DYCEVCQQGGEIILC

CHD4

371

Q14839
MGCAYSCCLEVCCGE

FAM153B

1

P0C7A2
SCCLEVCCGEDEIVY

FAM153B

6

P0C7A2
EGCCEACELGVCFLQ

RTP5

141

Q14D33
AVCVCQAGYTGAACE

SNED1

371

Q8TER0
CTVQCLCEEGGDVYC

TECTA

671

O75443
CESIGDCACFCDTIA

VWF

1091

P04275
CYLKEGNCSGCIQDC

SPAG1

496

Q07617
RGVCVDGQCICDSEY

TNR

211

Q92752
QCETYGTACAECCLA

SEMA3G

521

Q9NS98
DRCQELGCCFYEGVC

TEX29

36

Q8N6K0