Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	NCOR2 NCOA6 PITX1 GATA3 NR4A2 HAND1 RELA LEF1 TP53BP1	1.60e-06	417	54	9	GO:0061629
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	NCOR2 NCOA6 TLE4 PITX1 GATA3 NR4A2 HAND1 RELA LEF1 TP53BP1	3.09e-06	582	54	10	GO:0140297
GeneOntologyMolecularFunction	nuclear glucocorticoid receptor binding	NCOR2 NCOA6 NR4A2	2.06e-05	20	54	3	GO:0035259
GeneOntologyMolecularFunction	transcription factor binding	NCOR2 NCOA6 TLE4 PITX1 GATA3 NR4A2 HAND1 RELA LEF1 TP53BP1	2.91e-05	753	54	10	GO:0008134
GeneOntologyMolecularFunction	nuclear retinoid X receptor binding	NCOR2 NCOA6 NR4A2	3.19e-05	23	54	3	GO:0046965
GeneOntologyMolecularFunction	structural constituent of tooth enamel	AMELX AMELY	1.07e-04	6	54	2	GO:0030345
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	FOXJ2 PITX1 GATA3 NR4A2 HAND1 RELA ONECUT1 LEF1	1.22e-04	560	54	8	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	FOXJ2 PITX1 GATA3 NR4A2 HAND1 RELA ONECUT1 LEF1	1.31e-04	566	54	8	GO:0001216
GeneOntologyMolecularFunction	ankyrin repeat binding	SHANK1 RELA	1.49e-04	7	54	2	GO:0071532
GeneOntologyMolecularFunction	hydroxyapatite binding	AMELX AMELY	1.99e-04	8	54	2	GO:0046848
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	NCOR2 NCOA6 NR4A2	4.44e-04	55	54	3	GO:0042974
GeneOntologyMolecularFunction	transcription coregulator binding	GATA3 HAND1 RELA LEF1	5.58e-04	140	54	4	GO:0001221
GeneOntologyMolecularFunction	sodium ion binding	AMELX AMELY	6.40e-04	14	54	2	GO:0031402
GeneOntologyMolecularFunction	histone methyltransferase binding	NCOA6 GATA3	1.07e-03	18	54	2	GO:1990226
GeneOntologyMolecularFunction	nuclear receptor binding	NCOR2 NCOA6 NR4A2 LEF1	1.63e-03	187	54	4	GO:0016922
GeneOntologyMolecularFunction	extracellular matrix structural constituent conferring compression resistance	AMELX AMELY	1.75e-03	23	54	2	GO:0030021
GeneOntologyMolecularFunction	alkali metal ion binding	AMELX AMELY	2.24e-03	26	54	2	GO:0031420
GeneOntologyMolecularFunction	chromatin binding	NCOR2 NCOA6 TLE4 CHD2 RELA ONECUT1 LEF1	3.61e-03	739	54	7	GO:0003682
GeneOntologyCellularComponent	mRNA cleavage and polyadenylation specificity factor complex	WDR33 CSTF2 CSTF2T	4.29e-05	26	55	3	GO:0005847
GeneOntologyCellularComponent	mRNA cleavage factor complex	WDR33 CSTF2 CSTF2T	7.35e-05	31	55	3	GO:0005849
GeneOntologyCellularComponent	transcription regulator complex	NCOR2 NCOA6 TLE4 PITX1 NR4A2 HAND1 RELA LEF1	1.56e-04	596	55	8	GO:0005667
GeneOntologyCellularComponent	beta-catenin-TCF complex	TLE4 LEF1	5.20e-04	13	55	2	GO:1990907
MousePheno	small lower incisors	AMELX AMELY GATA3	5.77e-06	11	47	3	MP:0030080
MousePheno	short Tomes' process	AMELX AMELY	1.11e-05	2	47	2	MP:0030513
MousePheno	abnormal molar morphology	AMELX AMELY GATA3 LEF1	2.50e-05	51	47	4	MP:0002689
MousePheno	abnormal Tomes' process morphology	AMELX AMELY	3.31e-05	3	47	2	MP:0030512
MousePheno	absent teeth	AMELX AMELY LEF1	3.90e-05	20	47	3	MP:0030610
MousePheno	small incisors	AMELX AMELY GATA3	5.25e-05	22	47	3	MP:0030079
MousePheno	large mandible	AMELX AMELY	6.61e-05	4	47	2	MP:0030050
MousePheno	abnormal lower incisor morphology	AMELX AMELY GATA3	7.78e-05	25	47	3	MP:0030136
MousePheno	microdontia	AMELX AMELY GATA3	8.77e-05	26	47	3	MP:0030088
MousePheno	enamel pits	AMELX AMELY	1.10e-04	5	47	2	MP:0030460
MousePheno	abnormal hair follicle morphology	NCOA6 RHBDF2 GATA3 RELA LEF1	1.33e-04	148	47	5	MP:0000377
MousePheno	impaired placental function	NCOA6 HAND1	1.65e-04	6	47	2	MP:0006372
MousePheno	short upper incisors	AMELX AMELY	1.65e-04	6	47	2	MP:0030090
MousePheno	hindlimb oligodactyly	NCOA6 PITX1	2.30e-04	7	47	2	MP:0014281
MousePheno	small upper incisors	AMELX AMELY	2.30e-04	7	47	2	MP:0030081
MousePheno	short lower incisors	AMELX AMELY	2.30e-04	7	47	2	MP:0030089
MousePheno	abnormal enamel rod pattern	AMELX AMELY	3.06e-04	8	47	2	MP:0002649
MousePheno	abnormal zygomatic bone morphology	AMELX AMELY GATA3	3.47e-04	41	47	3	MP:0005270
MousePheno	abnormal melanosome morphology	RHBDF2 GATA3 LEF1	4.28e-04	44	47	3	MP:0005075
MousePheno	abnormal white adipose tissue physiology	NCOR2 RHBDF2 ARHGEF11	4.58e-04	45	47	3	MP:0005670
MousePheno	adipose tissue phenotype	NCOR2 NCOA6 CLSTN3 RHBDF2 TLE4 PITX1 CRYBG1 TNS2 CHD2 ARHGEF11 LEF1 RNF43 ALG13	4.66e-04	1383	47	13	MP:0005375
MousePheno	decreased tooth number	AMELX AMELY LEF1	4.89e-04	46	47	3	MP:0030608
MousePheno	abnormal tooth wear	AMELX AMELY	4.89e-04	10	47	2	MP:0030458
MousePheno	vertebral transformation	AMELX AMELY PITX1 MEX3B	4.99e-04	110	47	4	MP:0003036
MousePheno	abnormal incisor morphology	AMELX AMELY GATA3 LEF1	4.99e-04	110	47	4	MP:0005358
MousePheno	decreased spongiotrophoblast cell number	NCOA6 HAND1	5.97e-04	11	47	2	MP:0030989
MousePheno	abnormal pilosebaceous unit morphology	NCOA6 RHBDF2 GATA3 RELA LEF1	6.01e-04	205	47	5	MP:0030572
MousePheno	abnormal adipose tissue amount	NCOR2 NCOA6 CLSTN3 TLE4 PITX1 CRYBG1 TNS2 CHD2 LEF1 RNF43 ALG13	7.10e-04	1077	47	11	MP:0005452
MousePheno	reduced enamel thickness	AMELX AMELY	7.15e-04	12	47	2	MP:0002577
MousePheno	brittle teeth	AMELX AMELY	7.15e-04	12	47	2	MP:0000126
MousePheno	increased lung tissue damping	AMELX AMELY	8.43e-04	13	47	2	MP:0011047
MousePheno	abnormal gonial bone morphology	PITX1 GATA3	8.43e-04	13	47	2	MP:0008380
MousePheno	abnormal enamel mineralization	AMELX AMELY	8.43e-04	13	47	2	MP:0030450
MousePheno	abnormal tooth number	AMELX AMELY LEF1	8.71e-04	56	47	3	MP:0030611
MousePheno	short incisors	AMELX AMELY	9.81e-04	14	47	2	MP:0004830
Domain	CSTF2_hinge	CSTF2 CSTF2T	8.21e-06	2	54	2	IPR025742
Domain	Amelogenin	AMELX AMELY	8.21e-06	2	54	2	SM00818
Domain	Amelogenin	AMELX AMELY	8.21e-06	2	54	2	PF02948
Domain	CSTF2_hinge	CSTF2 CSTF2T	8.21e-06	2	54	2	PF14327
Domain	Amelogenin	AMELX AMELY	8.21e-06	2	54	2	IPR004116
Domain	CSTF_C	CSTF2 CSTF2T	8.21e-06	2	54	2	PF14304
Domain	CSTF_C	CSTF2 CSTF2T	8.21e-06	2	54	2	IPR026896
Pathway	REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS	WDR33 CSTF2 CSTF2T	2.33e-05	20	40	3	M497
Pathway	REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS	WDR33 CSTF2 CSTF2T	2.33e-05	20	40	3	MM15469
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION_TERMINATION	CASC3 WDR33 CSTF2 CSTF2T	2.75e-05	62	40	4	MM15426
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION_TERMINATION	CASC3 WDR33 CSTF2 CSTF2T	3.74e-05	67	40	4	M27694
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA	WDR33 CSTF2 CSTF2T	7.35e-05	29	40	3	M783
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA	WDR33 CSTF2 CSTF2T	7.35e-05	29	40	3	MM15444
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION	NCOR2 NCOA6 HELZ2 RELA	9.10e-05	84	40	4	M1008
Pathway	REACTOME_ADIPOGENESIS	NCOR2 NCOA6 HELZ2 RELA	2.58e-04	110	40	4	M48259
Pathway	REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS	NCOR2 ARRB2 INHA RNF111	3.38e-04	118	40	4	MM15588
Pathway	REACTOME_REPRESSION_OF_WNT_TARGET_GENES	TLE4 LEF1	3.48e-04	10	40	2	MM15156
Pathway	REACTOME_CYTOPROTECTION_BY_HMOX1	NCOR2 NCOA6 HELZ2	6.47e-04	60	40	3	M41830
Pathway	REACTOME_REPRESSION_OF_WNT_TARGET_GENES	TLE4 LEF1	6.99e-04	14	40	2	M27402
Pubmed	Sonic hedgehog regulates growth and morphogenesis of the tooth.	AMELX AMELY PITX1 LEF1	3.28e-08	21	55	4	11044393
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	SHANK1 FOXJ2 NCOR2 CHERP GSE1 RBM33 WDR33 GATA3 RNF216 CHD2 ONECUT1 TP53BP1 RNF111	3.58e-08	1203	55	13	29180619
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	CASC3 CHERP EIF4ENIF1 RBM33 WDR33 HELZ2 CSTF2 CHD2 MEX3B CSTF2T ALG13	4.63e-08	807	55	11	22681889
Pubmed	Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21.	AMELX AMELY PITX1	7.46e-08	6	55	3	20816801
Pubmed	Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis.	AMELX AMELY LEF1	3.12e-07	9	55	3	17335794
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	NCOR2 CHERP GSE1 RBM33 WDR33 ARHGEF11	4.15e-07	180	55	6	35198878
Pubmed	Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal.	AMELX AMELY LEF1	4.46e-07	10	55	3	27660324
Pubmed	Ectodermal Organ Development Is Regulated by a microRNA-26b-Lef-1-Wnt Signaling Axis.	AMELX AMELY LEF1	6.12e-07	11	55	3	32760291
Pubmed	Epithelial Cdc42 Deletion Induced Enamel Organ Defects and Cystogenesis.	AMELX AMELY LEF1	8.15e-07	12	55	3	29874522
Pubmed	FoxO6 regulates Hippo signaling and growth of the craniofacial complex.	AMELX AMELY LEF1	1.35e-06	14	55	3	30286078
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	CASC3 CHERP WDR33 TLE4 SCAPER CSTF2 NDFIP2 RELA LEF1 CSTF2T	1.62e-06	922	55	10	27609421
Pubmed	GATA3 is essential for separating patterning domains during facial morphogenesis.	PITX1 GATA3 HAND1	1.68e-06	15	55	3	34383890
Pubmed	Human transcription factor protein interaction networks.	NCOR2 NCOA6 EIF4ENIF1 GSE1 RBM33 WDR33 TLE4 PITX1 GATA3 CSTF2 RELA TP53BP1	1.88e-06	1429	55	12	35140242
Pubmed	Alk5-mediated transforming growth factor β signaling acts upstream of fibroblast growth factor 10 to regulate the proliferation and maintenance of dental epithelial stem cells.	AMELX AMELY LEF1	2.07e-06	16	55	3	21402782
Pubmed	A family of splice variants of CstF-64 expressed in vertebrate nervous systems.	CSTF2 CSTF2T	2.46e-06	2	55	2	19284619
Pubmed	Amelogenin-deficient mice display an amelogenesis imperfecta phenotype.	AMELX AMELY	2.46e-06	2	55	2	11406633
Pubmed	The receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenic pathway is elevated in amelogenin-null mice.	AMELX AMELY	2.46e-06	2	55	2	12851394
Pubmed	Amelogenin, the major protein of tooth enamel: a new phylogenetic marker for ordinal mammal relationships.	AMELX AMELY	2.46e-06	2	55	2	18346915
Pubmed	Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein.	CSTF2 CSTF2T	2.46e-06	2	55	2	12773396
Pubmed	Amelogenin X impacts age-dependent increase of frequency and number in labial incisor grooves in C57BL/6.	AMELX AMELY	2.46e-06	2	55	2	29337060
Pubmed	Molecular cloning and DNA sequence of rat amelogenin and a comparative analysis of mammalian amelogenin protein sequence divergence.	AMELX AMELY	2.46e-06	2	55	2	8297387
Pubmed	Thermal denaturation of a recombinant mouse amelogenin: circular dichroism and differential scanning calorimetric studies.	AMELX AMELY	2.46e-06	2	55	2	16284958
Pubmed	Human and mouse amelogenin gene loci are on the sex chromosomes.	AMELX AMELY	2.46e-06	2	55	2	2737677
Pubmed	Polyadenylation proteins CstF-64 and tauCstF-64 exhibit differential binding affinities for RNA polymers.	CSTF2 CSTF2T	2.46e-06	2	55	2	17029590
Pubmed	A solution NMR investigation into the early events of amelogenin nanosphere self-assembly initiated with sodium chloride or calcium chloride.	AMELX AMELY	2.46e-06	2	55	2	19086270
Pubmed	Molecular structure of the mouse amelogenin genomic DNA.	AMELX AMELY	2.46e-06	2	55	2	8988368
Pubmed	Hierarchical self-assembly of amelogenin and the regulation of biomineralization at the nanoscale.	AMELX AMELY	2.46e-06	2	55	2	21825148
Pubmed	Polypeptides translated from alternatively spliced transcripts of the amelogenin gene, devoid of the exon 6a, b, c region, have specific effects on tooth germ development in culture.	AMELX AMELY	2.46e-06	2	55	2	12489164
Pubmed	Amelogenin: a potential regulator of cementum-associated genes.	AMELX AMELY	2.46e-06	2	55	2	14653387
Pubmed	A synthetic, chemically modified ribozyme eliminates amelogenin, the major translation product in developing mouse enamel in vivo.	AMELX AMELY	2.46e-06	2	55	2	7489712
Pubmed	The leucine-rich amelogenin protein (LRAP) is primarily monomeric and unstructured in physiological solution.	AMELX AMELY	2.46e-06	2	55	2	25449314
Pubmed	High-yield recombinant bacterial expression of 13 C-, 15 N-labeled, serine-16 phosphorylated, murine amelogenin using a modified third generation genetic code expansion protocol.	AMELX AMELY	2.46e-06	2	55	2	36585836
Pubmed	Isolation and characterization of a mouse amelogenin expressed in Escherichia coli.	AMELX AMELY	2.46e-06	2	55	2	8062146
Pubmed	Transgenic mice that express normal and mutated amelogenins.	AMELX AMELY	2.46e-06	2	55	2	17384027
Pubmed	Alternative splicing of the mouse amelogenin primary RNA transcript.	AMELX AMELY	2.46e-06	2	55	2	7820782
Pubmed	Controlled Osteogenic Differentiation of Mouse Mesenchymal Stem Cells by Tetracycline-Controlled Transcriptional Activation of Amelogenin.	AMELX AMELY	2.46e-06	2	55	2	26709694
Pubmed	Amelogenin signal peptide mutation: correlation between mutations in the amelogenin gene (AMGX) and manifestations of X-linked amelogenesis imperfecta.	AMELX AMELY	2.46e-06	2	55	2	7782077
Pubmed	Comparison of body weight and gene expression in amelogenin null and wild-type mice.	AMELX AMELY	2.46e-06	2	55	2	16674684
Pubmed	Enamel ribbons, surface nodules, and octacalcium phosphate in C57BL/6 Amelx-/- mice and Amelx+/- lyonization.	AMELX AMELY	2.46e-06	2	55	2	27896287
Pubmed	Amelogenin-collagen interactions regulate calcium phosphate mineralization in vitro.	AMELX AMELY	2.46e-06	2	55	2	20404336
Pubmed	Maintenance of amelogenin gene expression by transformed epithelial cells of mouse enamel organ.	AMELX AMELY	2.46e-06	2	55	2	1444889
Pubmed	Identification of the functional activity of the [A-4] amelogenin gene splice product in newborn mouse ameloblasts.	AMELX AMELY	2.46e-06	2	55	2	18394981
Pubmed	A solution NMR investigation into the impaired self-assembly properties of two murine amelogenins containing the point mutations T21→I or P41→T.	AMELX AMELY	2.46e-06	2	55	2	23896516
Pubmed	Stage-Specific Role of Amelx Activation in Stepwise Ameloblast Induction from Mouse Induced Pluripotent Stem Cells.	AMELX AMELY	2.46e-06	2	55	2	34281250
Pubmed	The X-Y homologous gene amelogenin maps to the short arms of both the X and Y chromosomes and is highly conserved in primates.	AMELX AMELY	2.46e-06	2	55	2	1427830
Pubmed	Transgene animal model for protein expression and accumulation into forming enamel.	AMELX AMELY	2.46e-06	2	55	2	11063035
Pubmed	Regulation of amelogenin gene expression.	AMELX AMELY	2.46e-06	2	55	2	10200911
Pubmed	Developmental distribution of the polyadenylation protein CstF-64 and the variant tauCstF-64 in mouse and rat testis.	CSTF2 CSTF2T	2.46e-06	2	55	2	14681198
Pubmed	Truncated amelogenin and LRAP transgenes improve Amelx null mouse enamel.	AMELX AMELY	2.46e-06	2	55	2	26607574
Pubmed	A human X-Y homologous region encodes "amelogenin".	AMELX AMELY	2.46e-06	2	55	2	2004775
Pubmed	Loss of biological control of enamel mineralization in amelogenin-phosphorylation-deficient mice.	AMELX AMELY	2.46e-06	2	55	2	35219810
Pubmed	Of mice and men: anatomy of the amelogenin gene.	AMELX AMELY	2.46e-06	2	55	2	2689082
Pubmed	Altering biomineralization by protein design.	AMELX AMELY	2.46e-06	2	55	2	16707492
Pubmed	Amelogenin supramolecular assembly in nanospheres defined by a complex helix-coil-PPII helix 3D-structure.	AMELX AMELY	2.46e-06	2	55	2	21984897
Pubmed	Expression patterns of RelA and c-mip are associated with different glomerular diseases following anti-VEGF therapy.	CMIP RELA	2.46e-06	2	55	2	24067439
Pubmed	The murine amelogenin promoter: developmentally regulated expression in transgenic animals.	AMELX AMELY	2.46e-06	2	55	2	9084642
Pubmed	Cryogenic transmission electron microscopy study of amelogenin self-assembly at different pH.	AMELX AMELY	2.46e-06	2	55	2	21597263
Pubmed	Characterization of copy number variation in genomic regions containing STR loci using array comparative genomic hybridization.	AMELX AMELY	2.46e-06	2	55	2	23948316
Pubmed	Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells.	GATA3 LEF1	2.46e-06	2	55	2	18445004
Pubmed	Antisense inhibition of AMEL translation demonstrates supramolecular controls for enamel HAP crystal growth during embryonic mouse molar development.	AMELX AMELY	2.46e-06	2	55	2	8392462
Pubmed	Amelogenins as potential buffers during secretory-stage amelogenesis.	AMELX AMELY	2.46e-06	2	55	2	25535204
Pubmed	An amelogenin mutation leads to disruption of the odontogenic apparatus and aberrant expression of Notch1.	AMELX AMELY	2.46e-06	2	55	2	20923441
Pubmed	Model system for evaluation of alternative splicing: exon skipping.	AMELX AMELY	2.46e-06	2	55	2	11879574
Pubmed	Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region.	AMELX AMELY	2.46e-06	2	55	2	9878259
Pubmed	Analysis of self-assembly and apatite binding properties of amelogenin proteins lacking the hydrophilic C-terminal.	AMELX AMELY	2.46e-06	2	55	2	11852235
Pubmed	Amelogenin genes and sexual dimorphism of teeth in humans and mice.	AMELX AMELY	2.46e-06	2	55	2	1463023
Pubmed	Translocation of enamel proteins from inner enamel epithelia to odontoblasts during mouse tooth development.	AMELX AMELY	2.46e-06	2	55	2	8179220
Pubmed	Phosphorylation and ionic strength alter the LRAP-HAP interface in the N-terminus.	AMELX AMELY	2.46e-06	2	55	2	23477367
Pubmed	Protein interactions during assembly of the enamel organic extracellular matrix.	AMELX AMELY	2.46e-06	2	55	2	9041053
Pubmed	Highly acidic pH facilitates enamel protein self-assembly, apatite crystal growth and enamel protein interactions in the early enamel matrix.	AMELX AMELY	2.46e-06	2	55	2	36569763
Pubmed	Exon4 amelogenin transcripts in enamel biomineralization.	AMELX AMELY	2.46e-06	2	55	2	25792521
Pubmed	The leucine-rich amelogenin peptide alters the amelogenin null enamel phenotype.	AMELX AMELY	2.46e-06	2	55	2	18701811
Pubmed	Expression of amelogenin in odontoblasts.	AMELX AMELY	2.46e-06	2	55	2	12667550
Pubmed	Spatial- and temporal-restricted pattern for amelogenin gene expression during mouse molar tooth organogenesis.	AMELX AMELY	2.46e-06	2	55	2	3253061
Pubmed	Putative signaling action of amelogenin utilizes the Wnt/beta-catenin pathway.	AMELX AMELY	2.46e-06	2	55	2	19462488
Pubmed	Isolation and characterization of a pseudoautosomal region-specific genetic marker in C57BL/6 mice using genomic representational difference analysis.	AMELX AMELY	2.46e-06	2	55	2	8618899
Pubmed	A mutation in the mouse Amelx tri-tyrosyl domain results in impaired secretion of amelogenin and phenocopies human X-linked amelogenesis imperfecta.	AMELX AMELY	2.46e-06	2	55	2	20067920
Pubmed	Novel LRAP-binding partner revealing the plasminogen activation system as a regulator of cementoblast differentiation and mineral nodule formation in vitro.	AMELX AMELY	2.46e-06	2	55	2	31621902
Pubmed	Reuptake of extracellular amelogenin by dental epithelial cells results in increased levels of amelogenin mRNA through enhanced mRNA stabilization.	AMELX AMELY	2.46e-06	2	55	2	16293627
Pubmed	Leucine rich amelogenin peptide alters ameloblast differentiation in vivo.	AMELX AMELY	2.46e-06	2	55	2	23747796
Pubmed	Evolution in tooth developmental biology: of morphology and molecules.	AMELX AMELY	2.46e-06	2	55	2	8769659
Pubmed	Amelogenin promotes odontoblast-like MDPC-23 cell differentiation via activation of ERK1/2 and p38 MAPK.	AMELX AMELY	2.46e-06	2	55	2	21547453
Pubmed	Alternative splicing of the mouse amelogenin primary RNA transcript contributes to amelogenin heterogeneity.	AMELX AMELY	2.46e-06	2	55	2	1445358
Pubmed	Altered amelogenin self-assembly based on mutations observed in human X-linked amelogenesis imperfecta (AIH1).	AMELX AMELY	2.46e-06	2	55	2	11877393
Pubmed	Elevated levels of the 64-kDa cleavage stimulatory factor (CstF-64) in lipopolysaccharide-stimulated macrophages influence gene expression and induce alternative poly(A) site selection.	CSTF2 CSTF2T	2.46e-06	2	55	2	16207706
Pubmed	Partial rescue of the amelogenin null dental enamel phenotype.	AMELX AMELY	2.46e-06	2	55	2	18390542
Pubmed	Folding, assembly, and aggregation of recombinant murine amelogenins with T21I and P41T point mutations.	AMELX AMELY	2.46e-06	2	55	2	21540557
Pubmed	The energetic basis for hydroxyapatite mineralization by amelogenin variants provides insights into the origin of amelogenesis imperfecta.	AMELX AMELY	2.46e-06	2	55	2	31239344
Pubmed	Amelogenin in cranio-facial development: the tooth as a model to study the role of amelogenin during embryogenesis.	AMELX AMELY	2.46e-06	2	55	2	19097165
Pubmed	A solution NMR investigation into the murine amelogenin splice-variant LRAP (Leucine-Rich Amelogenin Protein).	AMELX AMELY	2.46e-06	2	55	2	20304108
Pubmed	Endoplasmic reticulum stress in amelogenesis imperfecta and phenotypic rescue using 4-phenylbutyrate.	AMELX AMELY	2.46e-06	2	55	2	24362885
Pubmed	Two related low molecular mass polypeptide isoforms of amelogenin have distinct activities in mouse tooth germ differentiation in vitro.	AMELX AMELY	2.46e-06	2	55	2	15647828
Pubmed	DNA sequence for cloned cDNA for murine amelogenin reveal the amino acid sequence for enamel-specific protein.	AMELX AMELY	2.46e-06	2	55	2	4015654
Pubmed	Weaker dental enamel explains dental decay.	AMELX AMELY	2.46e-06	2	55	2	25885796
Pubmed	Structural variation of the pseudoautosomal region between and within inbred mouse strains.	AMELX AMELY	2.46e-06	2	55	2	8552598
Pubmed	The amelogenin C-terminus is required for enamel development.	AMELX AMELY	2.46e-06	2	55	2	20042744
Pubmed	Leucine rich amelogenin peptide prevents ovariectomy-induced bone loss in mice.	AMELX AMELY	2.46e-06	2	55	2	34780561
Pubmed	Comparison of upstream regions of X- and Y-chromosomal amelogenin genes.	AMELX AMELY	2.46e-06	2	55	2	9714776
Pubmed	Overlapping and distinct functions of CstF64 and CstF64τ in mammalian mRNA 3' processing.	CSTF2 CSTF2T	2.46e-06	2	55	2	24149845
Pubmed	Amelogenin phosphorylation regulates tooth enamel formation by stabilizing a transient amorphous mineral precursor.	AMELX AMELY	2.46e-06	2	55	2	31919099
Interaction	ALG13 interactions	NCOR2 EIF4ENIF1 GSE1 RBM33 WDR33 PITX1 RNF43 MEX3B ALG13	1.29e-09	183	54	9	int:ALG13
Interaction	SMG7 interactions	NCOR2 ZSWIM8 NCOA6 EIF4ENIF1 GSE1 RBM33 TLE4 RNF43 MEX3B ALG13	1.11e-08	319	54	10	int:SMG7
Interaction	TLE3 interactions	FOXJ2 NCOR2 CHERP GSE1 TLE4 GATA3 CSTF2 RNF216 ALG13	6.31e-07	376	54	9	int:TLE3
Interaction	RBMS2 interactions	CASC3 EIF4ENIF1 WDR33 HELZ2 RNF43 MEX3B ALG13	4.60e-06	251	54	7	int:RBMS2
Interaction	PPARA interactions	NCOR2 NCOA6 HELZ2 GATA3 RELA	4.71e-06	92	54	5	int:PPARA
Interaction	STH interactions	PITX1 CSTF2 CSTF2T	1.44e-05	18	54	3	int:STH
Interaction	SP7 interactions	NCOR2 NCOA6 GSE1 RBM33 WDR33 TLE4 PITX1	1.60e-05	304	54	7	int:SP7
Interaction	FAM168B interactions	FAM222B PITX1 CSTF2 CSTF2T	1.75e-05	58	54	4	int:FAM168B
Interaction	R3HDM2 interactions	CASC3 ZSWIM8 EIF4ENIF1 MEX3B ALG13	2.45e-05	129	54	5	int:R3HDM2
Interaction	DTX2 interactions	NCOR2 CHERP EIF4ENIF1 GSE1 RBM33 WDR33 ARHGEF11	2.71e-05	330	54	7	int:DTX2
Interaction	TNIP2 interactions	CASC3 NCOR2 CHERP WDR33 TLE4 SCAPER CSTF2 NDFIP2 RELA LEF1 CSTF2T	3.65e-05	952	54	11	int:TNIP2
Interaction	ANKRD10 interactions	FAM222B PITX1 CSTF2	4.01e-05	25	54	3	int:ANKRD10
Interaction	DAZL interactions	CASC3 ZSWIM8 EIF4ENIF1 RBM33 ALG13	4.28e-05	145	54	5	int:DAZL
Interaction	LARP4B interactions	CASC3 CHERP EIF4ENIF1 RNF43 MEX3B ALG13	4.29e-05	240	54	6	int:LARP4B
Interaction	AKAP8L interactions	PITX1 CSTF2 RELA RNF43 CSTF2T TP53BP1	4.29e-05	240	54	6	int:AKAP8L
Interaction	EYA4 interactions	FOXJ2 NCOR2 GSE1 RBM33 WDR33 FAM222B	4.60e-05	243	54	6	int:EYA4
Interaction	TSC1 interactions	SHANK1 CASC3 FAM222B PITX1 CSTF2 TNS2 TP53BP1	5.23e-05	366	54	7	int:TSC1
Interaction	CPEB4 interactions	EIF4ENIF1 RNF43 MEX3B CSTF2T ALG13	6.07e-05	156	54	5	int:CPEB4
Interaction	RNF4 interactions	SHANK1 FOXJ2 NCOR2 CHERP GSE1 RBM33 WDR33 GATA3 RNF216 CHD2 ONECUT1 TP53BP1 RNF111	6.84e-05	1412	54	13	int:RNF4
Interaction	NCOR2 interactions	NCOR2 NCOA6 GATA3 NR4A2 RELA ALG13	7.28e-05	264	54	6	int:NCOR2
Interaction	R3HDM1 interactions	EIF4ENIF1 RNF43 MEX3B ALG13	7.58e-05	84	54	4	int:R3HDM1
Interaction	ASB3 interactions	ZSWIM8 EIF4ENIF1 GSE1 TNS2	7.58e-05	84	54	4	int:ASB3
Interaction	TNRC6A interactions	NCOA6 EIF4ENIF1 RNF43 MEX3B TP53BP1 ALG13	1.01e-04	280	54	6	int:TNRC6A
Interaction	TOP3B interactions	VWA5B2 SEMA4F NCOR2 NCOA6 EIF4ENIF1 RHBDF2 RBM33 PITX1 HELZ2 ARHGEF11 RNF43 MEX3B TP53BP1	1.03e-04	1470	54	13	int:TOP3B
Interaction	PAPOLA interactions	WDR33 CSTF2 RELA CSTF2T	1.08e-04	92	54	4	int:PAPOLA
Interaction	FOXI1 interactions	NCOR2 GSE1 TLE4 CSTF2T	1.08e-04	92	54	4	int:FOXI1
Interaction	TLX3 interactions	NCOR2 NCOA6 GSE1 TLE4 PITX1 TP53BP1	1.24e-04	291	54	6	int:TLX3
Interaction	MAPK3 interactions	ARRB2 CHERP GSE1 NR4A2 RELA CSTF2T TP53BP1	1.25e-04	421	54	7	int:MAPK3
Interaction	NUP35 interactions	NCOR2 NCOA6 EIF4ENIF1 GSE1 RBM33 WDR33 FAM222B	1.31e-04	424	54	7	int:NUP35
Interaction	SEC16A interactions	NCOR2 EIF4ENIF1 WDR33 RELA RNF43 MEX3B ALG13	1.35e-04	426	54	7	int:SEC16A
Interaction	FUBP3 interactions	EIF4ENIF1 RBM33 GATA3 RNF43 MEX3B ALG13	1.39e-04	297	54	6	int:FUBP3
Interaction	C1orf94 interactions	CHERP GSE1 PITX1 TNS2	1.67e-04	103	54	4	int:C1orf94
Interaction	TLE5 interactions	TLE4 PITX1 GATA3 CSTF2 TNS2 RELA CSTF2T	1.72e-04	443	54	7	int:TLE5
Interaction	CREBBP interactions	NCOR2 NCOA6 EIF4ENIF1 GATA3 RELA ONECUT1 TP53BP1 RNF111	1.81e-04	599	54	8	int:CREBBP
Interaction	GATA2 interactions	NCOR2 NCOA6 GSE1 TLE4 GATA3	1.91e-04	199	54	5	int:GATA2
Interaction	PCF11 interactions	WDR33 GATA3 CSTF2 ALG13	2.23e-04	111	54	4	int:PCF11
Interaction	BAG2 interactions	VWA5B2 NCOA6 EIF4ENIF1 RBM33 TLE4 RELA RNF43 CSTF2T	2.34e-04	622	54	8	int:BAG2
Interaction	TBR1 interactions	NCOR2 GSE1 TLE4 PITX1	2.39e-04	113	54	4	int:TBR1
Interaction	NFIC interactions	NCOR2 GSE1 GATA3 RELA TP53BP1	2.45e-04	210	54	5	int:NFIC
Interaction	USP54 interactions	CHERP CSTF2 TNS2 RNF43 MEX3B	2.56e-04	212	54	5	int:USP54
Interaction	TLE1 interactions	TLE4 GATA3 RELA LEF1 ALG13	2.61e-04	213	54	5	int:TLE1
Interaction	TBXT interactions	NCOR2 NCOA6 GSE1 TLE4	2.64e-04	116	54	4	int:TBXT
Interaction	APBA2 interactions	CLSTN3 RELA RNF43	2.89e-04	48	54	3	int:APBA2
Interaction	PLSCR3 interactions	PITX1 TNS2 RNF43	2.89e-04	48	54	3	int:PLSCR3
Interaction	UFSP1 interactions	FAM222B PITX1 CSTF2	3.07e-04	49	54	3	int:UFSP1
Interaction	PAPOLB interactions	CSTF2 CSTF2T	3.13e-04	10	54	2	int:PAPOLB
Interaction	NCOA3 interactions	NCOR2 GATA3 RELA TP53BP1 ALG13	3.29e-04	224	54	5	int:NCOA3
Interaction	RCOR1 interactions	NCOR2 ARRB2 EIF4ENIF1 GSE1 GATA3 CSTF2T TP53BP1	3.33e-04	494	54	7	int:RCOR1
Interaction	MCRIP2 interactions	CASC3 MEX3B ALG13	3.46e-04	51	54	3	int:MCRIP2
Interaction	TGFBR3 interactions	ARRB2 INHA MEX3B	3.66e-04	52	54	3	int:TGFBR3
Interaction	TRIP6 interactions	GSE1 FAM222B TNS2 RELA RNF43 MEX3B	3.79e-04	358	54	6	int:TRIP6
Interaction	PAX9 interactions	NCOR2 NCOA6 GSE1 TLE4	4.07e-04	130	54	4	int:PAX9
Interaction	ABCA1 interactions	SHANK1 RELA ARHGEF11	4.09e-04	54	54	3	int:ABCA1
Interaction	HGS interactions	ARRB2 RHBDF2 PITX1 CSTF2 RNF43 CSTF2T TP53BP1	4.69e-04	523	54	7	int:HGS
Interaction	LASP1 interactions	NCOR2 CHERP PITX1 TNS2 CSTF2T	5.15e-04	247	54	5	int:LASP1
Interaction	FMR1 interactions	CASC3 NCOR2 EIF4ENIF1 TLE4 MEX3B TP53BP1 ALG13	5.43e-04	536	54	7	int:FMR1
Interaction	MKRN2 interactions	SEMA4F EIF4ENIF1 RELA RNF43 MEX3B ALG13	5.57e-04	385	54	6	int:MKRN2
Interaction	FBXO22 interactions	NCOR2 RBM33 CSTF2 CHD2 RP1 ARHGEF11 TP53BP1	5.68e-04	540	54	7	int:FBXO22
Interaction	NCOA6 interactions	NCOR2 NCOA6 RELA TP53BP1	6.15e-04	145	54	4	int:NCOA6
Interaction	HELZ interactions	NCOR2 EIF4ENIF1 RNF43 MEX3B ALG13	6.16e-04	257	54	5	int:HELZ
Interaction	EWSR1 interactions	CASC3 NCOA6 CHERP EIF4ENIF1 RBM33 PITX1 CSTF2 CSTF2T TP53BP1	6.20e-04	906	54	9	int:EWSR1
Interaction	XRN1 interactions	VWA5B2 EIF4ENIF1 RHBDF2 RNF43 ALG13	6.27e-04	258	54	5	int:XRN1
Interaction	PAIP2 interactions	CASC3 MEX3B ALG13	6.45e-04	63	54	3	int:PAIP2
Interaction	SMO interactions	ARRB2 SCAPER HELZ2	6.45e-04	63	54	3	int:SMO
Interaction	C10orf55 interactions	FAM222B PITX1 TP53BP1	7.06e-04	65	54	3	int:C10orf55
Interaction	PRRC2B interactions	EIF4ENIF1 GATA3 RNF43 MEX3B ALG13	7.08e-04	265	54	5	int:PRRC2B
Interaction	KDM1A interactions	NCOR2 ARRB2 EIF4ENIF1 GSE1 TLE4 GATA3 RELA CSTF2T TP53BP1	8.13e-04	941	54	9	int:KDM1A
Interaction	NFE2L2 interactions	NCOR2 RELA LEF1 RNF111	8.68e-04	159	54	4	int:NFE2L2
Interaction	UBE2D3 interactions	RNF216 RELA RNF43 MEX3B RNF111	9.50e-04	283	54	5	int:UBE2D3
Interaction	EGR1 interactions	PITX1 RELA TP53BP1	9.52e-04	72	54	3	int:EGR1
GeneFamily	Ring finger proteins	RNF216 RNF43 MEX3B RNF111	2.57e-03	275	38	4	58
GeneFamily	Tudor domain containing	TP53BP1 ALG13	2.73e-03	37	38	2	780
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF37 ARHGEF11	8.48e-03	66	38	2	722
GeneFamily	RNA binding motif containing	RBM33 CSTF2 CSTF2T	1.00e-02	213	38	3	725
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500	SHANK1 SEMA4F WDR33 FAM222B PITX1 GATA3 HAND1 CHD2 LEF1	3.77e-06	492	54	9	Facebase_RNAseq_e10.5_Mandibular Arch_500
ToppCell	TCGA-Adrenal\|World / Sample_Type by Project: Shred V9	VWA5B2 INHA KCNG4 HAND1	3.11e-05	145	55	4	522ad2bc90b8ec326fcbc7b2250b09566efeeca2
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	KCNG4 GATA3 TNS2 RP1	3.28e-05	147	55	4	9566398275cad79223db90ffe640830acf2db864
ToppCell	URO-Lymphocyte-T_NK-Treg\|URO / Disease, Lineage and Cell Type	SEMA4F HEATR4 GATA3 LEF1	3.93e-05	154	55	4	73fe0e26088a1b012902cc062ffbb3e4d2ff09f9
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CASC3 HELZ2 GATA3 RNF43	4.24e-05	157	55	4	4183dbed6b31ebe13ef33eb19ba6d0fb4f625953
ToppCell	Severe-Lymphoid-NK-Proliferating_T\|Severe / Condition, Lineage, Cell class and cell subclass	SEMA4F CLSTN3 GATA3 NDFIP2	4.56e-05	160	55	4	cb2276d9bd78508644420e9580d3c17b914224cb
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Nefm_(MGE-derived_cortical_interneurons--basket_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	HEATR4 KCNG4 CR2	4.58e-05	56	55	3	ac776a6e8d0b5596dc492a05235e518cbfc7b5ed
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Nefm_(MGE-derived_cortical_interneurons--basket_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	HEATR4 KCNG4 CR2	4.58e-05	56	55	3	0417516b9241a756fb2bcd611691c675ca98030d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	GATA3 NR4A2 CRYBG1 ALG13	5.39e-05	167	55	4	4b6853efefea5178280ba7c31facda0fbd1cc469
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4F GATA3 ADAM33 LEF1	6.04e-05	172	55	4	33c201aaa98acbf1901b6fa6ce0d3ff8012a4d94
ToppCell	facs-Kidney-nan-18m-Lymphocytic-T_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4F GATA3 NR4A2 LEF1	6.46e-05	175	55	4	84d91843b34504636d5af6bda9930031409a1627
ToppCell	facs-Kidney-nan-18m-Lymphocytic-T_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4F GATA3 NR4A2 LEF1	6.46e-05	175	55	4	2368aa8318ab83e0e0fd539a17264f9e1d755cf1
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Tac1-Inhibitory_Neuron.Gad1Gad2_Pvalb.Tac1_(Interneuron,_Basket_1)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	DPYS RP1 CR2	7.16e-05	65	55	3	25d2f56f6cd982a227772f8a3b453cdcc8516a47
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Tac1-Inhibitory_Neuron.Gad1Gad2_Pvalb.Tac1_(Interneuron,_Basket_1)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	DPYS RP1 CR2	7.16e-05	65	55	3	d7d571be0662967e6d8d934e45f928a2f9e1c06a
ToppCell	facs-Spleen-nan-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARRB2 GATA3 NR4A2 LEF1	7.21e-05	180	55	4	407fd8f61a757626e082b6e2eefd3a33276e6b71
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FOXJ2 SEMA4F RNF216 CSTF2T	7.52e-05	182	55	4	4a85429d365c4b2d73fc921f261b4b7635ac40bd
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FOXJ2 SEMA4F RNF216 CSTF2T	7.52e-05	182	55	4	53213af34af3337f5edc734d3b7b79e4349eac0d
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FOXJ2 SEMA4F RNF216 CSTF2T	7.52e-05	182	55	4	7909089ed6325c44edd6f9b7e8b1d542398222ea
ToppCell	10x5'v1-week_17-19-Lymphocytic_T-T_NK-Treg\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SEMA4F NCOA6 GATA3 NR4A2	7.68e-05	183	55	4	5fb933acfe6bc555c90dba71e75d4be658763945
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CMIP ARRB2 RHBDF2 TLE4	8.52e-05	188	55	4	3be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NR4A2 CRYBG1 LEF1 ALG13	8.52e-05	188	55	4	939790f133eac9c12d08db6ddb5f08f5107844e3
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-T_cells-Activated_CD4_T\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARRB2 GATA3 NR4A2 LEF1	8.70e-05	189	55	4	1a891ae8517086fcf6443660976aef6413fa79ae
ToppCell	Fetal_29-31_weeks-Immune-monocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CMIP ARRB2 RHBDF2 CRYBG1	8.88e-05	190	55	4	ad297172a74a80ed5c10f921e15efd1da0fd2d6b
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-SELL+_CD8_T\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARRB2 GATA3 NR4A2 LEF1	8.88e-05	190	55	4	d83fdc352ebb0c2f2a7c2138bf6e3b7a8ce83a6a
ToppCell	ILEUM-non-inflamed-(1)_CD8_Trm\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TLE4 GATA3 NR4A2 CRYBG1	9.25e-05	192	55	4	a9f89043c97cd2b0ba165e69ee5681094410af37
ToppCell	Sepsis-URO-Lymphocyte-T/NK-Treg\|URO / Disease, condition lineage and cell class	SEMA4F CFAP20DC GATA3 LEF1	1.00e-04	196	55	4	8812d7365fb2b33feff93782d60776e932499a43
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells-Activated_CD4_T\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GATA3 NR4A2 CRYBG1 LEF1	1.02e-04	197	55	4	2f2e5a5e1cb00b9e51c1a9f86d34ac65cb8b3999
Computational	Signaling.	AMELY TLE4 PITX1 NR4A2 CSTF2 ARHGEF11 CR2	1.69e-04	374	35	7	MODULE_94
Drug	Hydralazine hydrochloride [304-20-1]; Down 200; 20.4uM; PC3; HT_HG-U133A	NCOR2 WDR33 TNS2 RNF216 ARHGEF11 RNF43	6.90e-06	196	54	6	3724_DN
Drug	Vigabatrin [60643-86-9]; Down 200; 31uM; MCF7; HT_HG-U133A	ZSWIM8 RHBDF2 SCAPER NR4A2 TNS2 ARHGEF11	7.11e-06	197	54	6	5415_DN
Drug	Roxithromycin [80214-83-1]; Up 200; 4.8uM; PC3; HT_HG-U133A	NCOR2 ZSWIM8 DPYS TLE4 PITX1 NR4A2	7.11e-06	197	54	6	4192_UP
Drug	ganoine	AMELX AMELY	1.65e-05	3	54	2	CID000131592
Drug	HBGG	AMELX AMELY NCOA6	1.88e-05	22	54	3	CID000125044
Disease	amelogenesis imperfecta type 1E (implicated_via_orthology)	AMELX AMELY	3.29e-06	2	54	2	DOID:0110058 (implicated_via_orthology)
Disease	autosomal dominant hypocalcemia (biomarker_via_orthology)	AMELX AMELY	1.97e-05	4	54	2	DOID:0090109 (biomarker_via_orthology)
Disease	cholesteryl esters to total lipids in large HDL percentage	NCOR2 CMIP TP53BP1	1.75e-04	59	54	3	EFO_0022248
Disease	triglycerides to total lipids in large HDL percentage	NCOR2 CMIP TP53BP1	1.84e-04	60	54	3	EFO_0022330
Disease	free cholesterol measurement, very low density lipoprotein cholesterol measurement	NCOR2 CMIP TP53BP1 RNF111	6.52e-04	215	54	4	EFO_0008317, EFO_0008591
Disease	epilepsy (biomarker_via_orthology)	NR4A2 RELA	6.75e-04	21	54	2	DOID:1826 (biomarker_via_orthology)
Disease	very low density lipoprotein cholesterol measurement, lipid measurement	NCOR2 CMIP TP53BP1 RNF111	7.10e-04	220	54	4	EFO_0004529, EFO_0008317
Disease	total cholesterol measurement, very low density lipoprotein cholesterol measurement	NCOR2 CMIP TP53BP1 RNF111	7.59e-04	224	54	4	EFO_0004574, EFO_0008317
Disease	cholesteryl ester measurement, very low density lipoprotein cholesterol measurement	NCOR2 CMIP TP53BP1 RNF111	7.72e-04	225	54	4	EFO_0008317, EFO_0010351
Disease	very low density lipoprotein cholesterol measurement, phospholipid measurement	NCOR2 CMIP TP53BP1 RNF111	8.25e-04	229	54	4	EFO_0004639, EFO_0008317
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	NCOR2 CMIP TP53BP1 RNF111	1.03e-03	243	54	4	EFO_0004612, EFO_0020944
Disease	prostate carcinoma in situ (is_marker_for)	RELA LEF1	1.21e-03	28	54	2	DOID:8634 (is_marker_for)
Disease	very low density lipoprotein cholesterol measurement	NCOR2 CMIP TP53BP1 RNF111	1.32e-03	260	54	4	EFO_0008317
Disease	Epileptic encephalopathy	CHD2 ALG13	1.38e-03	30	54	2	C0543888
Disease	eosinophil count	NCOR2 CMIP CHERP GSE1 RHBDF2 HELZ2 GATA3 RELA TP53BP1	1.40e-03	1488	54	9	EFO_0004842
Disease	Colorectal Carcinoma	SHANK1 CLSTN3 GSE1 NR4A2 LEF1 RNF43	1.74e-03	702	54	6	C0009402
Disease	Colonic Neoplasms	RELA LEF1 TP53BP1	2.74e-03	152	54	3	C0009375
Disease	Breast Carcinoma	GATA3 ADAM33 RELA LEF1 TP53BP1	3.00e-03	538	54	5	C0678222
Disease	Malignant tumor of colon	RELA LEF1 TP53BP1	3.11e-03	159	54	3	C0007102

Protein segments in the cluster

Peptide	Gene	Start	Entry
LGAAFAMPLPPHPGH	AMELX	11	Q99217
VGAAFAMPLPPHPGH	AMELY	11	Q99218
LPPRLQHSMHYGHDP	ALG13	611	Q9NP73
HRGHQPPPEMAGHSL	CLSTN3	821	Q9BQT9
GSMAQLPHHHVPEPA	ARHGEF37	441	A1IGU5
PGSLPPLHPSAMHLH	GSE1	286	Q14687
ATRHPGAAPMPVHPP	ARHGEF11	1081	O15085
MHGPTGHCPHPRVLP	CMIP	311	Q8IY22
GPHRDHPLGGVHPME	ADAM33	751	Q9BZ11
MHHVPGHESRGPPPH	CSTF2	356	P33240
PFVLMHPKPHDHIPL	ARRB2	341	P32121
PVQHPHHPSPPQGMH	RBM33	346	Q96EV2
RFSHHMIPGPPGPHT	LEF1	241	Q9UJU2
MGRAIPPERHSPHHL	NCOR2	1331	Q9Y618
HAAHHVMGPPLRPDP	DPYS	291	Q14117
MPMPSRDGGLHPRHH	KCNG4	1	Q8TDN1
HPHNPLLHGGRKMPD	FAM222B	221	Q8WU58
MVPINGLPPHHPHAH	ONECUT1	241	Q9UBC0
PHPAHPMLHEPFLFG	HAND1	16	O96004
AHHMVPRPSVPPPGA	FOXJ2	546	Q9P0K8
MIPHAGGHPLDTPHL	OC90	11	Q02509
HPSGSLAPPHHPMQP	NCOA6	231	Q14686
RKPDPEPGRMDHHQP	NDFIP2	86	Q9NV92
PMHPPSSLSFGPHHP	GATA3	421	P23771
PGMNLPHPGLHPHQT	CASC3	576	O15234
PLECPALPMIHNGHH	CR2	151	P20023
GDFPAEMGPPHHHPG	CHERP	576	Q8IWX8
PHLPASHGPQMHGHP	CHD2	1606	O14647
PRPLIHHPCMHPDML	HEATR4	161	Q86WZ0
HHPCMHPDMLGRPPS	HEATR4	166	Q86WZ0
GPVAVPMSLGHAPPH	INHA	161	P05111
GPPMHHASGHDTRGP	CSTF2T	361	Q9H0L4
PAPHFAMPPIHEDHL	CRYBG1	726	Q9Y4K1
VPPHPRHYPLMFCHV	HELZ2	771	Q9BYK8
EPARPPGHGIHMHEK	SCAPER	516	Q9BY12
HSPPHPVAVAAPGMP	RP1	136	P56715
LSPPLHMAPGAGEHH	MEX3B	441	Q6ZN04
GPLHVPMNPEPAGSH	NR4A2	196	P43354
PPPPHDMGPAFHLAR	PITX1	21	P78337
HPLMDRPVFPADGHP	SEMA4F	411	O95754
PGMGPRHHRFPRAAH	RNF43	381	Q68DV7
PREPVSPAGPHHHRP	SPATA31E1	1406	Q6ZUB1
EHNLPMHFGPQPRHR	RNF216	851	Q9NWF9
HHAHPPHPPEMETGG	SHANK1	1016	Q9Y566
HVPMVRPAHQLHPGL	EIF4ENIF1	816	Q9NRA8
PIHAANLHIMHPHPP	CFAP20DC	211	Q6ZVT6
AHECMPHHPGSPSEP	C10orf105	71	Q8TEF2
MMQHPTRAHERPPPH	RNF111	761	Q6ZNA4
TRAHERPPPHPHRMH	RNF111	766	Q6ZNA4
RPPPHPHRMHPNYGH	RNF111	771	Q6ZNA4
PHHHMRVPAIPPNLT	TLE4	426	Q04727
DMPQPPHGHVLHRHM	TP53BP1	1226	Q12888
AHPAHPMPHMPRPAV	ZSWIM8	1526	A7E2V4
HPSEPHQPHLMLEGG	VWA5B2	271	Q8N398
GPPNHHMGPMSERRH	WDR33	961	Q9C0J8
FRHPEEMDRPHAPHP	RHBDF2	196	Q6PJF5
PPHRPHPHELVGKDC	RELA	81	Q04206
PLLLPACGHHHAPMP	TNS2	736	Q63HR2