Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainARHGEF5_35

ARHGEF35 ARHGEF5

3.82e-062372PF15441
DomainARHGEF5/35_N

ARHGEF35 ARHGEF5

3.82e-062372IPR029212
DomainRhoGAP

ARHGAP22 ARHGAP35

6.70e-0362372SM00324
DomainRhoGAP

ARHGAP22 ARHGAP35

6.91e-0363372PF00620
DomainRHOGAP

ARHGAP22 ARHGAP35

7.13e-0364372PS50238
DomainRhoGAP_dom

ARHGAP22 ARHGAP35

7.13e-0364372IPR000198
Domain-

ARHGAP22 ARHGAP35

7.13e-03643721.10.555.10
DomainUSP_CS

USP37 USP47

7.56e-0366372IPR018200
DomainUSP_1

USP37 USP47

8.47e-0370372PS00972
DomainUCH

USP37 USP47

8.71e-0371372PF00443
DomainUSP_2

USP37 USP47

8.71e-0371372PS00973
DomainUSP_3

USP37 USP47

8.95e-0372372PS50235
DomainUSP_dom

USP37 USP47

8.95e-0372372IPR028889
DomainPeptidase_C19_UCH

USP37 USP47

8.95e-0372372IPR001394
DomainRho_GTPase_activation_prot

ARHGAP22 ARHGAP35

1.31e-0288372IPR008936
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

TOGARAM1 ARHGAP35 SMG7 CEP72

9.53e-0522537412168954
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

HIVEP3 TOGARAM1 ARHGAP35 USP37 CEP72

1.68e-0449337515368895
Pubmed

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.

RALGAPA1 ERCC5 SUPT20H

1.98e-0410637331024071
Pubmed

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.

USP37 USP47

2.75e-042337214715245
Pubmed

HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development.

KAT7 ERG

2.99e-042437221149574
Pubmed

The Vertebrate Genome Annotation browser 10 years on.

KCNMA1 CFAP47 PCLO

6.99e-0416337324316575
Pubmed

Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.

ARHGAP35 SMG7 CEP72

7.76e-0416937331462741
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

DCAF1 KAT7 PCLO BCORL1

8.12e-0439637426687479
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

KCNMA1 RALGAPA1 HIVEP3 ARHGAP35 CPT1A SMG7 CHRM3

8.65e-04148937728611215
Pubmed

PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.

PCLO BCORL1

8.80e-044137222325352
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

CFAP47 FREM2 RBM28 PCLO BCORL1

1.04e-0373637529676528
Cytoband13q13.3

FREM2 SUPT20H

2.53e-042937213q13.3
Cytoband7q35

ARHGEF35 ARHGEF5

9.14e-04553727q35
CytobandEnsembl 112 genes in cytogenetic band chr7q35

ARHGEF35 ARHGEF5

1.31e-0366372chr7q35
CytobandEnsembl 112 genes in cytogenetic band chr13q13

FREM2 SUPT20H

2.02e-0382372chr13q13
GeneFamilyRho GTPase activating proteins|BCH domain containing

ARHGAP22 ARHGAP35

2.16e-0350252721
GeneFamilyUbiquitin specific peptidases

USP37 USP47

2.70e-0356252366
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ARHGEF35 ARHGEF5

3.73e-0366252722
ToppCell10x_3'_v3-blood_(10x_3'_v3)-hematologic-hematopoietic_progenitor-hematopoietic_stem_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ARHGAP22 ERG CHRM3 PCLO

1.05e-051703645bb577e2c4bd275fbe4ee23ff8c007b2fcb90e56
ToppCell10x_3'_v3-blood_(10x_3'_v3)-hematologic-hematopoietic_progenitor|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ARHGAP22 ERG CHRM3 PCLO

1.16e-0517436466df78280f657978c4a568010ae7d7943869af90
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ARHGEF35 CEP72 CHRM3 PCLO

1.18e-05175364fd8b5b756f3df4a04938785f3d9edbb6f1cd20f6
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|368C / Donor, Lineage, Cell class and subclass (all cells)

ARHGEF35 CEP72 CHRM3 PCLO

1.18e-0517536436c140540497bbe1c5f08fac2d94f08cac18fabb
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KCNMA1 HIVEP3 MUC12 PHACTR3

1.53e-0518736487b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KCNMA1 HIVEP3 MUC12 PHACTR3

1.53e-0518736442a1267bfc27b4460b8409ada580a87c4385841c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KCNMA1 HIVEP3 MUC12 PHACTR3

1.53e-0518736464afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCellCOVID-19_Severe-HSPC|COVID-19_Severe / disease group, cell group and cell class

ARHGAP22 ERG CHRM3 PCLO

1.60e-0518936496015439971e2e5b8d6294ca5a6b873c7774e925
ToppCellCOVID-19_Severe-HSPC|World / disease group, cell group and cell class

ARHGAP22 ERG CHRM3 PCLO

1.60e-05189364555c0b13f1508b9e3712b36d77144e73e828bc76
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Adenocarcinoma-NOS-3|TCGA-Pancreas / Sample_Type by Project: Shred V9

CCDC83 MUC12 SPATA31A6

8.58e-051063632ad8d93ef0be9425c60fba86fc22926e456ef3d2
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

KCNMA1 ARHGAP22 ZNF414

1.64e-04132363a1fda8c5287168c4f159203ed27cadfb4ce1b131
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNMA1 NSMF ZNF414

1.95e-04140363e442c46979d725ec82f525a001c46d971fcade4d
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DCAF1 FREM2 RAB11FIP4

2.04e-04142363a05b320cf182b2aaf18df7c40045dc65b659bf20
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DCAF1 FREM2 RAB11FIP4

2.04e-04142363d52da766e031f7409eb5a7a9fa88f48e14a79d8b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGEF35 MUC12 CHRM3

2.17e-041453639964d6d3769be2f35d86268fe044cecd1d5a1616
ToppCell343B-Epithelial_cells-Epithelial-E_(AT2)|343B / Donor, Lineage, Cell class and subclass (all cells)

DCAF1 ARHGEF35 PHACTR3

2.17e-04145363cb534333fba44b241b14fb0d7b74e843f4e7f9f8
ToppCell343B-Epithelial_cells-Epithelial-E_(AT2)-|343B / Donor, Lineage, Cell class and subclass (all cells)

DCAF1 ARHGEF35 PHACTR3

2.17e-0414536380684ec249fa445c1b35f94608a4a6824d53f2d9
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Mucinous-3|TCGA-Stomach / Sample_Type by Project: Shred V9

ARHGAP22 MUC12 ERG

2.30e-04148363c95a732163050cfb5d604c2a4c9eb1afa9f19a95
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF384 CPT1A SPINK5

3.05e-04163363d2fcd6f561748f7d29a051c504f016952ba32d0f
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

KCNMA1 RALGAPA1 CHRM3

3.05e-041633631e8730d75cccf7292010683ab4e81a69d8e3bfa9
ToppCellIIF-Other-HSPC|IIF / Disease, Lineage and Cell Type

ERG CHRM3 PCLO

3.05e-041633631e0d38fbed38ac48478868a1480172a1a3f7c1b7
ToppCelldroplet-Lung-nan-3m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP22 ERG CEP72

3.11e-0416436378de403446fe0eb375c82ff1832cc5fbb8e20afa
ToppCellcontrol-Epithelial-Ionocyte|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KCNMA1 NSMF CHRM3

3.16e-041653635cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGAP22 ERG CEP72

3.16e-04165363c39f0479955c4e23921f7a450d3bc251a002200f
ToppCellNS-control-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KCNMA1 NSMF CHRM3

3.22e-041663636d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_MEMP|bone_marrow / Manually curated celltypes from each tissue

ARHGAP22 ERG PCLO

3.22e-041663639788486582cc2c5f28b9ea015e235732f9fefb1e
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGAP22 FREM2 RBM28

3.28e-04167363d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCellHealthy_donor-HSPC|World / disease group, cell group and cell class (v2)

ARHGAP22 ERG CHRM3

3.28e-0416736370630ebdfee8171d625811844f8a7c94736d101e
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGAP22 FREM2 RBM28

3.28e-041673637abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FREM2 ERG SPATA31A6

3.34e-041683638e9046b661642293eee640ead91d43db9d8daae0
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FREM2 ERG SPATA31A6

3.34e-04168363c7d66e5d9311ceaab3f144f1516b49b8812976b8
ToppCellcontrol-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KCNMA1 NSMF CHRM3

3.34e-04168363327b02f19f4a8607c033203824fdc60a1254331f
ToppCell368C-Lymphocytic-NK_cells-NK_cell_E|368C / Donor, Lineage, Cell class and subclass (all cells)

CEP72 PCLO BCORL1

3.39e-041693630d96c0b4fd26fbc0bf44ff7bed2936eebcc55b74
ToppCell3'_v3-blood-Hematopoietic_progenitors-HSC-MPP|blood / Manually curated celltypes from each tissue

ERG CHRM3 PCLO

3.45e-041703631443d7fccc81088dd42dcbb9361e269872542274
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2-Exc_L5_FEZF2_SCN7A|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FREM2 ERG SPATA31A6

3.45e-04170363a0047551619547971d55165156f61f090948f902
ToppCellHealthy_donor-HSPC|Healthy_donor / disease group, cell group and cell class (v2)

ARHGAP22 ERG CHRM3

3.57e-04172363bc7549faadfc92c683c0e26bea380458706774b5
ToppCellmild-Others-CD34+_GATA2+_cells|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ERG CHRM3 SPINK5

3.57e-04172363379f6f271e653d5e404851e51a189bd582bb0f43
ToppCellPND28-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAB11FIP4 CEP72 BCORL1

3.57e-04172363eba1568d4307e91c94fc616549057cbed8df5840
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HIVEP3 ERG CHRM3

3.63e-04173363f193c63cc536d891c9d23043765e320252bb6e65
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAB11FIP4 ERG CPT1A

3.70e-04174363b2fc2a756f8e373ad903bd416d9de703d945fa1c
ToppCellsevere_COVID-19-HSPC|severe_COVID-19 / disease group, cell group and cell class (v2)

ARHGAP22 ERG CHRM3

3.70e-041743636d35bacf073537b272ff821e604c899fb9ce6a7c
ToppCellNS-moderate-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KCNMA1 CHRM3 PHACTR3

3.76e-04175363a1e0a15c69211d6db2edeb101476f0f6e08b90c8
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_MEMP|lymph-node_spleen / Manually curated celltypes from each tissue

ARHGAP22 ERG CHRM3

3.82e-0417636323a8ec42ebd42c539865a12d09773af90f3f8848
ToppCell368C-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CEP72 PCLO BCORL1

3.88e-04177363946803293a7955116c80f403e99e4093e798ca3f
ToppCell3'_v3-blood-Hematopoietic_progenitors|blood / Manually curated celltypes from each tissue

ERG CHRM3 PCLO

3.88e-0417736322c77077951889e63489abfabf90900655655c82
ToppCell3'_v3-Lung-Hematopoietic_progenitors|Lung / Manually curated celltypes from each tissue

ERG CHRM3 PCLO

3.95e-04178363c7895ba2e2e93b26da91faa2a3bf9d070dd4c3bd
ToppCellwk_20-22-Epithelial-Proximal_epithelial-basal_late|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

FREM2 CEP72 SPINK5

3.95e-0417836303f22485074b3cbf9a6ad4d543c5bbfa826dc741
ToppCell3'_v3-Lung-Hematopoietic_progenitors-HSC-MPP|Lung / Manually curated celltypes from each tissue

ERG CHRM3 PCLO

4.01e-041793632c03b82ec9b4dee2501752b8d83e7028f0aaed77
ToppCellCOVID-19_Convalescent-Classical_Monocyte-cMono_4|Classical_Monocyte / Disease condition and Cell class

DCAF1 KAT7 ARHGAP35

4.01e-041793639d51318ac198a8801bd5c7031ebf2b0c74ffeeb6
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ARHGAP22 ERG CHRM3

4.21e-041823636497eeafb2b137e70261ec0314782831892a940d
ToppCellControl-Hematopoietic_SC-HSPC|Control / Disease group, lineage and cell class

ARHGAP22 ERG CHRM3

4.21e-0418236314e347c0e6444410f1948851407bb18c706569f4
ToppCellControl-Hematopoietic_SC|Control / Disease group, lineage and cell class

ARHGAP22 ERG CHRM3

4.21e-0418236343243c6bae2ac7fa3fd1f193a17f61ee4d938ea9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KCNMA1 HIVEP3 PHACTR3

4.21e-04182363a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ARHGAP22 ERG CHRM3

4.21e-04182363d0ebf2f0d5370458ab81485a0017c311077133d5
ToppCellPBMC-Control-Hematopoietic-HSPC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ARHGAP22 ERG CHRM3

4.21e-04182363918286422b3eab32d962b49aa07b1b9512e51d9d
ToppCellPBMC-Control-Hematopoietic-HSPC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ARHGAP22 ERG CHRM3

4.21e-04182363bd1626261803324084fafca2f6665b50854e7fae
ToppCellhealthy_donor-Myeloid-Monocytic-SC_&_Eosinophil|healthy_donor / Disease condition, Lineage, Cell class and subclass

ARHGAP22 ERG CHRM3

4.21e-041823636bd6c32c48fecd6d03ac8a09e405b3b99bdc12ae
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ARHGAP22 ERG CHRM3

4.21e-041823632a6d1246bfb5899a0861c7f2f8fb9b43b0df8acc
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ARHGAP22 ERG CHRM3

4.21e-041823630d9b8c900da8cbae9cde72aecd4026b1ac2bbd67
ToppCellNS-critical-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KCNMA1 CHRM3 PHACTR3

4.28e-04183363ba43bca2b45be1008eebd3f033cecb061fb3a966
ToppCellCOVID-19_Severe-Hematopoietic_SC-HSPC|COVID-19_Severe / Disease group, lineage and cell class

ARHGAP22 ERG CHRM3

4.28e-041833634146b1c0e5f76d25226745abfa28f77127a444fc
ToppCellCOVID-19_Severe-Hematopoietic_SC|COVID-19_Severe / Disease group, lineage and cell class

ARHGAP22 ERG CHRM3

4.28e-0418336392aab7ce65aca17988bc2add4ff9fb8384e2c21b
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ARHGAP22 FREM2 NENF

4.28e-04183363274f274cf60daa30d6a4cd603a3af7823bfb8016
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 PCLO PHACTR3

4.35e-04184363ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 PCLO PHACTR3

4.35e-041843632cbed6462fea2622871bb7e49b0df3d984239281
ToppCellPBMC-Severe-Hematopoietic-HSPC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ARHGAP22 ERG CHRM3

4.35e-04184363a6169613c6493b947a176493f542368bfa935dab
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 PCLO PHACTR3

4.35e-041843632b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPBMC-Severe-Hematopoietic-HSPC-HSPC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ARHGAP22 ERG CHRM3

4.35e-0418436351d0447699e3b8f01abbde83f26b748bc9f3c723
ToppCellPBMC-Severe-Hematopoietic-HSPC-HSPC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ARHGAP22 ERG CHRM3

4.35e-04184363cc01c19180861f491a8dc16d60fabd1215fc4525
ToppCell3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor_MEMP|bone_marrow / Manually curated celltypes from each tissue

ARHGAP22 ERG CHRM3

4.35e-04184363b81a2a95944cee8fec13d63dc0d95496e67aa937
ToppCellPBMC-Severe-Hematopoietic-HSPC-HSPC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ARHGAP22 ERG CHRM3

4.35e-04184363f7b0bb45a9055ab34e98b251217f6ec38c75ca22
ToppCellcritical-Epithelial-Ionocyte|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KCNMA1 CHRM3 PHACTR3

4.35e-0418436358d36577eff814d46d72f031f3533d71549e3d6e
ToppCellPBMC-Severe-Hematopoietic-HSPC-HSPC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ARHGAP22 ERG CHRM3

4.35e-04184363492c680f0769ba4e651d09c2e8e5d5d271ed08aa
ToppCellPBMC-Severe-Hematopoietic-HSPC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ARHGAP22 ERG CHRM3

4.35e-0418436326edbf84216538b80f1ffcc079ee6e385a71fbf9
ToppCellCOVID-19_Moderate-HSPC|COVID-19_Moderate / disease group, cell group and cell class

ARHGAP22 ERG CHRM3

4.42e-04185363cacc6ab5f26f6c803894567fb838ea06eaa7efe5
ToppCellE12.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ARHGAP22 FREM2 CHRM3

4.49e-041863631587667e5084ac43505d027af925ba711e228150
ToppCell3'_v3-blood-Hematopoietic_progenitors-Progenitor_Erythro-Mega|blood / Manually curated celltypes from each tissue

ARHGAP22 ERG CHRM3

4.49e-0418636359c115bbbb4bca4ad80be1809d8a0422b8438ea3
ToppCellHealthy-HSPC|World / disease group, cell group and cell class

ARHGAP22 ERG CHRM3

4.56e-041873638cd9e5499e5c2b2321ecbcf780df37fe0f165ac9
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

CHRM3 PCLO SPINK5

4.63e-04188363ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

KCNMA1 FREM2 CHRM3

4.63e-04188363b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CFAP47 FREM2 PCLO

4.70e-041893637659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellCOVID_vent-Myeloid-Monocytic-SC_&_Eosinophil|COVID_vent / Disease condition, Lineage, Cell class and subclass

ARHGAP22 ERG CHRM3

4.70e-041893632157a2d40613f7d5ce2e7dbd266df441e449cdaf
ToppCellAdult|World / Lineage, Cell type, age group and donor

KCNMA1 ARHGAP22 CPT1A

4.70e-041893635cd285bfad973125d46d704fec18b21266a63379
ToppCellHealthy-HSPC|Healthy / disease group, cell group and cell class

ARHGAP22 ERG CHRM3

4.70e-04189363214b225effc40ca1b83dd8052f2a7b80b65d4938
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCNMA1 FREM2 CHRM3

4.78e-04190363e102622f05c7f3e1bd8b224ea159d57033793ee0
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FREM2 ARHGEF35 ARHGEF5

4.78e-04190363b855b8b7d3439023390ca44629c1a99f5d4c6801
ToppCellhematopoetic_progenitors-CD34+_MEP_1|World / Lineage and Cell class

ARHGAP22 ERG CHRM3

4.85e-0419136391327184ca40bfb8c9e904991b1be503aaccd7bc
ToppCellP07-Mesenchymal-mesenchymal_fibroblast|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

HIVEP3 NENF PHACTR3

4.85e-04191363a05e9a7eb137d804570dd7d8905975d735738767
ToppCellMegakaryocytic-erythropoietic-MEP|World / Lineage, cell class and subclass

ARHGAP22 ERG CHRM3

4.85e-0419136391bbc9d3a9ecc49262060faeb0047764828c1960
ToppCellMegakaryocytic-erythropoietic-MEP-MEP|World / Lineage, cell class and subclass

ARHGAP22 ERG CHRM3

4.85e-04191363b71dc4e27a22955926547493fc959afc20208566
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FREM2 CHRM3 PCLO

4.92e-04192363cc9911e182a289779a2612bc213daae5607689e7
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

RALGAPA1 SYNRG USP37

5.00e-04193363abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCNMA1 FREM2 CHRM3

5.00e-041933630256e8fe4a47f2e2a43ef9d19bfc047d20806d69
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FREM2 RAB11FIP4 CHRM3

5.00e-041933630ef076417ffe2dd1cbc2c3d1e35c7f8522af143b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HIVEP3 ERG CHRM3

5.15e-0419536323ced69fd904f1d4114b1a7f99f4b5f65ea8824b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HIVEP3 ERG CHRM3

5.23e-04196363adee900dcd16dbaba15c58bdcace09ba20214950
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KCNMA1 RAB11FIP4 ERG

5.31e-041973636e111ba16fc8adde782b3f7da250248cddf11228
ToppCellCF-Myeloid-Monocyte_Macrophage|Myeloid / Disease state, Lineage and Cell class

KCNMA1 ARHGAP22 NENF

5.31e-0419736377b150a987c0a8abe73920d93d69a590ebbbdfea
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Deep_Layer|World / Primary Cells by Cluster

KCNMA1 NSMF SPINK5

5.31e-0419736341e823b14697827f657b13adb3afa581bd91a9cb
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HIVEP3 ERG CHRM3

5.39e-0419836307701c73137947ed4a27e225975329235bbb8734
ComputationalNeighborhood of MYST2

RALGAPA1 KAT7 ZNF384 USP37

2.03e-04172194GCM_MYST2
ComputationalNeighborhood of PPM1D

KAT7 USP37

9.38e-0426192GCM_PPM1D
ComputationalNeighborhood of ZNF198

RALGAPA1 KAT7 USP37

1.07e-03117193GCM_ZNF198
ComputationalNeighborhood of DFFA

RALGAPA1 KAT7 ZNF384

1.42e-03129193GCM_DFFA
ComputationalNeighborhood of UBE2N

RALGAPA1 KAT7 ZNF384

2.36e-03154193GCM_UBE2N
ComputationalGenes in the cancer module 332.

ERCC5 SUPT20H

2.80e-0345192MODULE_332
DrugLidocaone hydrochloride [73-78-9]; Up 200; 14.8uM; PC3; HT_HG-U133A

DCAF1 RALGAPA1 ARHGAP35 ERG KIAA0319L SPINK5

5.92e-071963664596_UP
DrugFluorometholone [426-13-1]; Up 200; 10.6uM; PC3; HT_HG-U133A

RALGAPA1 HIVEP3 ARHGAP22 CPT1A KIAA0319L SPINK5

5.92e-071963665771_UP
DrugIsocarboxazid [59-63-2]; Up 200; 17.2uM; PC3; HT_HG-U133A

DCAF1 RALGAPA1 ARHGAP35 SMG7 KIAA0319L SPINK5

6.28e-071983667383_UP
DrugGlycocholic acid [475-31-0]; Down 200; 8.6uM; MCF7; HT_HG-U133A

RALGAPA1 HIVEP3 SYNRG CEP72 BCORL1

1.33e-051953653315_DN
DrugCarbachol [51-83-2]; Up 200; 21.8uM; MCF7; HT_HG-U133A

KCNMA1 DCAF1 RALGAPA1 HIVEP3 ERG

1.36e-051963653380_UP
DrugGramine [87-52-5]; Down 200; 23uM; HL60; HT_HG-U133A

HIVEP3 SYNRG ARHGAP35 CPT1A SMG7

1.40e-051973652143_DN
DrugLY 294002; Up 200; 10uM; MCF7; HT_HG-U133A

DCAF1 RALGAPA1 PCLO KIAA0319L

1.95e-041833645599_UP
DrugAH23848 hemicalcium salt hydrate; Up 200; 1uM; PC3; HT_HG-U133A

SUPT20H CPT1A SMG7 KIAA0319L

2.16e-041883646885_UP
DrugBenzamil hydrochloride [2898-76-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A

HIVEP3 ERG CHRM3 PCLO

2.34e-041923643635_UP
DrugFlumethasone [2135-17-3]; Down 200; 9.8uM; PC3; HT_HG-U133A

KCNMA1 HIVEP3 CPT1A SMG7

2.38e-041933643712_DN
DrugGlycocholic acid [475-31-0]; Down 200; 8.6uM; MCF7; HT_HG-U133A

SYNRG ARHGAP35 SMG7 CEP72

2.43e-041943645316_DN
DrugCitalopram hydrobromide [59729-32-7]; Down 200; 1uM; MCF7; HT_HG-U133A

HIVEP3 CPT1A SMG7 SPINK5

2.43e-041943643903_DN
DrugUrapidil hydrochloride [64887-14-5]; Up 200; 9.4uM; HL60; HT_HG-U133A

ARHGAP35 SMG7 PCLO SPINK5

2.48e-041953643078_UP
DrugPrazosin hydrochloride [19237-84-4]; Down 200; 9.6uM; MCF7; HT_HG-U133A

SMG7 CEP72 CHRM3 SPINK5

2.48e-041953645416_DN
DrugS(+)-Terguride [37686-84-3]; Up 200; 11.8uM; HL60; HT_HG-U133A

RALGAPA1 ARHGAP35 CPT1A PCLO

2.48e-041953643082_UP
DrugClofazimine [2030-63-9]; Down 200; 8.4uM; MCF7; HT_HG-U133A

CHRM3 PCLO KIAA0319L SPINK5

2.48e-041953645277_DN
DrugICI182,780; Up 200; 1uM; MCF7; HT_HG-U133A

RALGAPA1 HIVEP3 ERG SPINK5

2.53e-041963645926_UP
DrugGlipizide [29094-61-9]; Up 200; 9uM; MCF7; HT_HG-U133A

HIVEP3 CHRM3 BCORL1 KIAA0319L

2.53e-041963641508_UP
DrugPizotifen malate [5189-11-7]; Down 200; 9.4uM; HL60; HT_HG-U133A

ARHGAP35 CPT1A NENF KIAA0319L

2.53e-041963643134_DN
DrugIndapamide [26807-65-8]; Down 200; 10.6uM; MCF7; HT_HG-U133A

KCNMA1 HIVEP3 SYNRG CHRM3

2.53e-041963643970_DN
DrugNadolol [42200-33-9]; Down 200; 13uM; MCF7; HT_HG-U133A

HIVEP3 ARHGAP35 CHRM3 KIAA0319L

2.53e-041963643359_DN
DrugDobutamine hydrochloride [49745-95-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A

CPT1A SMG7 KIAA0319L SPINK5

2.53e-041963645386_DN
DrugChlorprothixene hydrochloride [6469-93-8]; Down 200; 11.4uM; PC3; HT_HG-U133A

RALGAPA1 HIVEP3 SMG7 PCLO

2.53e-041963646692_DN
Drughaloperidol; Up 200; 10uM; MCF7; HT_HG-U133A

DCAF1 ARHGAP35 ERG KIAA0319L

2.53e-041963646923_UP
DrugLincomycin hydrochloride [859-18-7]; Up 200; 9uM; MCF7; HT_HG-U133A

RALGAPA1 SMG7 CEP72 BCORL1

2.58e-041973647411_UP
DrugTiratricol, 3,3',5-triiodothyroacetic acid [51-24-1]; Down 200; 6.4uM; MCF7; HT_HG-U133A

DCAF1 RALGAPA1 HIVEP3 NENF

2.58e-041973642259_DN
DrugRapamycin; Up 200; 0.1uM; HL60; HT_HG-U133A

DCAF1 CPT1A SMG7 KIAA0319L

2.58e-041973646180_UP
DrugPentolinium bitartrate [52-62-0]; Down 200; 7.4uM; MCF7; HT_HG-U133A

ARHGAP35 CPT1A KIAA0319L SPINK5

2.58e-041973644699_DN
DrugSB 203580; Down 200; 1uM; PC3; HT_HG-U133A

DCAF1 RALGAPA1 HIVEP3 KIAA0319L

2.63e-041983646894_DN
DrugMilrinone [78415-72-2]; Up 200; 19uM; PC3; HT_HG-U133A

RALGAPA1 ERG CPT1A SPINK5

2.63e-041983645856_UP
DrugTrichlorfon [52-68-6]; Down 200; 15.6uM; HL60; HT_HG-U133A

DCAF1 CPT1A SMG7 CEP72

2.63e-041983641839_DN
DrugKetorolac tromethamine [74103-07-4]; Down 200; 10.6uM; MCF7; HT_HG-U133A

HIVEP3 ARHGAP35 BCORL1 SPINK5

2.63e-041983646489_DN
DrugGabapentin [60142-96-3]; Up 200; 23.4uM; PC3; HT_HG-U133A

KCNMA1 RALGAPA1 ARHGAP35 SPINK5

2.63e-041983645875_UP
DrugGlimepiride [93479-97-1]; Down 200; 8.2uM; MCF7; HT_HG-U133A

NSMF ARHGAP35 SMG7 BCORL1

2.63e-041983642809_DN
DrugOleandomycin phosphate [7060-74-4]; Up 200; 5uM; MCF7; HT_HG-U133A

HIVEP3 ERG PCLO KIAA0319L

2.63e-041983641518_UP
DrugDibucaine [85-79-0]; Down 200; 11.6uM; HL60; HG-U133A

TOGARAM1 SMG7 CEP72 BCORL1

2.63e-041983641969_DN
DrugIsopyrin hydrochloride [18342-39-7]; Down 200; 14.2uM; MCF7; HT_HG-U133A

KCNMA1 ARHGAP35 BCORL1 KIAA0319L

2.68e-041993646097_DN
DrugHexetidine [141-94-6]; Down 200; 11.8uM; PC3; HT_HG-U133A

KCNMA1 HIVEP3 ARHGAP35 SMG7

2.68e-041993646319_DN
DrugTamoxifen citrate [54965-24-1]; Up 200; 7uM; PC3; HT_HG-U133A

SUPT20H SMG7 BCORL1 KIAA0319L

2.68e-041993642050_UP
DrugCarbetapentane citrate [23142-01-0]; Down 200; 7.6uM; PC3; HT_HG-U133A

ZNF384 SYNRG ARHGAP35 CPT1A

2.68e-041993644649_DN
DrugDelsoline [509-18-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A

KCNMA1 SYNRG CPT1A KIAA0319L

2.68e-041993646075_DN
DrugPF-00562151-00 [351320-12-2]; Down 200; 10uM; MCF7; HT_HG-U133A

KCNMA1 HIVEP3 PCLO KIAA0319L

2.73e-042003645917_DN
DrugAmiodarone hydrochloride [19774-82-4]; Up 200; 5.8uM; HL60; HT_HG-U133A

KCNMA1 ERG CHRM3 PCLO

2.73e-042003642434_UP
DrugOxymetazoline hydrochloride [2315-02-8]; Up 200; 13.4uM; MCF7; HT_HG-U133A

SYNRG ARHGAP35 KIAA0319L SPINK5

2.73e-042003642278_UP
DiseaseAbnormality of refraction

KCNMA1 HIVEP3 ERG PCLO PHACTR3

8.50e-04673335HP_0000539
DiseaseHypermetropia, Myopia

KCNMA1 HIVEP3 ARHGAP22

1.22e-03189333HP_0000540, HP_0000545
Diseasesusceptibility to mumps measurement

KCNMA1 CHRM3

3.20e-0375332EFO_0008404
Diseasedepressive symptom measurement, response to antidepressant

HIVEP3 ARHGAP22

4.37e-0388332EFO_0007006, GO_0036276

Protein segments in the cluster

PeptideGeneStartEntry
SEHLDMAPFSSDLGS

ARHGEF5

131

Q12774
PHLAKTEMTASSSSD

ERG

26

P11308
KPSSEQMDQDHSSSD

CHRM3

321

P20309
EESESHLCSDSTPKM

BCORL1

951

Q5H9F3
SEHLDMAPFSSDLGS

ARHGEF35

131

A5YM69
DPDTSMDSYAKSLLH

CPT1A

431

P50416
PDSMDTEDSASSQKL

CEP72

301

Q9P209
DLMSSSDESTILHLS

CCDC83

306

Q8IWF9
APAKSSDHSEEDSDL

RBM28

276

Q9NW13
EDKSLVHTPSMTTSD

RAB11FIP4

186

Q86YS3
QPSSSHSLDADKMAS

OR8U8

261

P0C7N1
TKEADLPMTAASHSS

DCAF1

871

Q9Y4B6
DMSLKDSGSDLSHRP

KAT7

156

O95251
SSSSSVHEPKMDALI

KCNMA1

56

Q12791
SPDSFSSLDSEMCKD

SPINK5

981

Q9NQ38
LSSSLMHSESELDSD

KIAA0319L

996

Q8IZA0
PLSLSATDMDSDDSL

FREM2

581

Q5SZK8
LDDSSPTGLMKDTHT

ARNTL2

536

Q8WYA1
AESPSMHRKQELDSS

PCLO

76

Q9Y6V0
SLDEDSDSSPSHKKG

PCLO

1736

Q9Y6V0
AKMSLDPADLTHDTT

NENF

101

Q9UMX5
PMKADTSHDSRDSSD

NSMF

296

Q6X4W1
YPKHDDDMSSSGSDT

CFAP47

2031

Q6ZTR5
LSSAAHLDDAAKMPS

PHACTR3

171

Q96KR7
DLKHVMSDSSLDLPT

SYNRG

846

Q9UMZ2
TKASDHMPESLLASS

SPATA31A6

871

Q5VVP1
SLLEKPSELMSHSSS

SMG7

916

Q92540
AEVDSESLPSSSKMH

ERCC5

301

P28715
SLPSLSKDHSKLSME

ARHGAP35

1001

Q9NRY4
SSSEDPKSLDLDHSM

ARHGAP22

556

Q7Z5H3
DMLATAEPSSSETDK

ZNF414

11

Q96IQ9
SMDTESKSDQLTPHS

ZNF384

66

Q8TF68
MPSDSDDSLTKKLRH

RALGAPA1

1886

Q6GYQ0
KADEESDSQMSPSHS

SUPT20H

371

Q8NEM7
LEMLSSLSSDPSDTK

HIVEP3

1496

Q5T1R4
MAPLDHTSDKSLLDA

USP47

101

Q96K76
SKRDASPSLSHEDDD

USP37

716

Q86T82
TSDLESPDSAMKLDL

TOGARAM1

991

Q9Y4F4
RSEESKASHSSPDAM

MUC12

576

Q9UKN1