Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	KDEL sequence binding	KDELR2 KDELR1	3.73e-05	3	71	2	GO:0005046
GeneOntologyMolecularFunction	ER retention sequence binding	KDELR2 KDELR1	1.24e-04	5	71	2	GO:0046923
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	DENND5B PLEKHG1 TRIO MCF2 ARHGEF4 TIAM2	1.72e-04	231	71	6	GO:0005085
GeneOntologyMolecularFunction	guanylyltransferase activity	TENT4B TENT4A	2.59e-04	7	71	2	GO:0070568
GeneOntologyMolecularFunction	metal-dependent deubiquitinase activity	PRPF8 STAMBP	8.04e-04	12	71	2	GO:0140492
GeneOntologyMolecularFunction	poly(A) RNA polymerase activity	TENT4B TENT4A	8.04e-04	12	71	2	GO:1990817
GeneOntologyBiologicalProcess	polyadenylation-dependent RNA catabolic process	TENT4B TENT4A	1.14e-05	2	70	2	GO:0043633
GeneOntologyBiologicalProcess	polyadenylation-dependent ncRNA catabolic process	TENT4B TENT4A	1.14e-05	2	70	2	GO:0043634
GeneOntologyBiologicalProcess	negative regulation of nuclear-transcribed mRNA poly(A) tail shortening	TENT4B TENT4A	3.40e-05	3	70	2	GO:0060212
GeneOntologyBiologicalProcess	sperm flagellum assembly	CFAP47 DNHD1 CFAP54 SPEF2	3.91e-05	56	70	4	GO:0120316
GeneOntologyBiologicalProcess	RNA 3' uridylation	TENT4B TENT4A	1.13e-04	5	70	2	GO:0071076
GeneOntologyBiologicalProcess	regulation of small GTPase mediated signal transduction	PLEKHG1 FAM13A TRIO MCF2 ARHGEF4 TIAM2 STAMBP	1.35e-04	333	70	7	GO:0051056
GeneOntologyBiologicalProcess	positive regulation of 3'-UTR-mediated mRNA stabilization	TENT4B TENT4A	1.69e-04	6	70	2	GO:1905870
GeneOntologyBiologicalProcess	motile cilium assembly	CFAP47 DNHD1 CFAP54 SPEF2	2.29e-04	88	70	4	GO:0044458
GeneOntologyBiologicalProcess	cell surface receptor protein tyrosine phosphatase signaling pathway	PTPRD TRIO	2.36e-04	7	70	2	GO:0007185
GeneOntologyBiologicalProcess	regulation of 3'-UTR-mediated mRNA stabilization	TENT4B TENT4A	2.36e-04	7	70	2	GO:1905868
GeneOntologyCellularComponent	TRAMP complex	TENT4B TENT4A	1.13e-04	5	71	2	GO:0031499
Domain	GDS_CDC24_CS	PLEKHG1 TRIO MCF2 ARHGEF4 TIAM2	3.10e-07	39	69	5	IPR001331
Domain	DH_1	PLEKHG1 TRIO MCF2 ARHGEF4 TIAM2	3.54e-06	63	69	5	PS00741
Domain	RhoGEF	PLEKHG1 TRIO MCF2 ARHGEF4 TIAM2	5.17e-06	68	69	5	SM00325
Domain	RhoGEF	PLEKHG1 TRIO MCF2 ARHGEF4 TIAM2	5.97e-06	70	69	5	PF00621
Domain	DH_2	PLEKHG1 TRIO MCF2 ARHGEF4 TIAM2	5.97e-06	70	69	5	PS50010
Domain	DH-domain	PLEKHG1 TRIO MCF2 ARHGEF4 TIAM2	6.40e-06	71	69	5	IPR000219
Domain	-	PLEKHG1 TRIO MCF2 ARHGEF4 TIAM2	6.40e-06	71	69	5	1.20.900.10
Domain	DUF3402	STRIP2 STRIP1	1.35e-05	2	69	2	PF11882
Domain	N1221	STRIP2 STRIP1	1.35e-05	2	69	2	PF07923
Domain	DUF3402	STRIP2 STRIP1	1.35e-05	2	69	2	IPR021819
Domain	DUF3402	STRIP2 STRIP1	1.35e-05	2	69	2	SM01293
Domain	N1221	STRIP2 STRIP1	1.35e-05	2	69	2	SM01292
Domain	N1221	STRIP2 STRIP1	1.35e-05	2	69	2	IPR012486
Domain	ER_ret_rcpt	KDELR2 KDELR1	4.03e-05	3	69	2	IPR000133
Domain	ER_lumen_recept	KDELR2 KDELR1	4.03e-05	3	69	2	PF00810
Domain	ER_LUMEN_RECEPTOR_1	KDELR2 KDELR1	4.03e-05	3	69	2	PS00951
Domain	ER_LUMEN_RECEPTOR_2	KDELR2 KDELR1	4.03e-05	3	69	2	PS00952
Domain	FAT	ATR TRRAP	2.00e-04	6	69	2	PS51189
Domain	FATC	ATR TRRAP	2.00e-04	6	69	2	PS51190
Domain	FAT	ATR TRRAP	2.00e-04	6	69	2	PF02259
Domain	PIK-rel_kinase_FAT	ATR TRRAP	2.00e-04	6	69	2	IPR003151
Domain	FATC_dom	ATR TRRAP	2.00e-04	6	69	2	IPR003152
Domain	PIK_FAT	ATR TRRAP	2.00e-04	6	69	2	IPR014009
Domain	FATC	ATR TRRAP	2.00e-04	6	69	2	SM01343
Domain	PH	PLEKHG1 TRIO MCF2 ARHGEF4 FERMT2 TIAM2	2.00e-04	229	69	6	PF00169
Domain	PAP_assoc	TENT4B TENT4A	2.79e-04	7	69	2	PF03828
Domain	PAP_assoc	TENT4B TENT4A	2.79e-04	7	69	2	IPR002058
Domain	PH	PLEKHG1 TRIO MCF2 ARHGEF4 FERMT2 TIAM2	5.63e-04	278	69	6	SM00233
Domain	PH_DOMAIN	PLEKHG1 TRIO MCF2 ARHGEF4 FERMT2 TIAM2	5.74e-04	279	69	6	PS50003
Domain	PH_domain	PLEKHG1 TRIO MCF2 ARHGEF4 FERMT2 TIAM2	5.85e-04	280	69	6	IPR001849
Domain	NTP_transf_2	TENT4B TENT4A	7.24e-04	11	69	2	PF01909
Domain	Polymerase_NTP_transf_dom	TENT4B TENT4A	7.24e-04	11	69	2	IPR002934
Domain	JAB_MPN	PRPF8 STAMBP	8.67e-04	12	69	2	SM00232
Domain	JAMM/MPN+_dom	PRPF8 STAMBP	8.67e-04	12	69	2	IPR000555
Domain	JAB	PRPF8 STAMBP	8.67e-04	12	69	2	PF01398
Domain	-	ATR TRRAP	1.56e-03	16	69	2	1.10.1070.11
Domain	PI3Kc	ATR TRRAP	1.56e-03	16	69	2	SM00146
Domain	TPR-like_helical_dom	CFAP54 SAMD9 ATR TTC39A TRRAP	1.70e-03	233	69	5	IPR011990
Domain	PI3/4_kinase_cat_dom	ATR TRRAP	1.98e-03	18	69	2	IPR000403
Domain	PI3_PI4_kinase	ATR TRRAP	1.98e-03	18	69	2	PF00454
Domain	PI3_4_KINASE_3	ATR TRRAP	1.98e-03	18	69	2	PS50290
Domain	PI3_4_KINASE_1	ATR TRRAP	1.98e-03	18	69	2	PS00915
Domain	PI3_4_KINASE_2	ATR TRRAP	1.98e-03	18	69	2	PS00916
Domain	PRAME_family	PRAMEF1 PRAMEF2	2.21e-03	19	69	2	IPR026271
Domain	-	PLEKHG1 TRIO MCF2 ARHGEF4 FERMT2 TIAM2	3.20e-03	391	69	6	2.30.29.30
Domain	RCC1/BLIP-II	UBR5 TECPR2	3.24e-03	23	69	2	IPR009091
Pathway	REACTOME_RAC1_GTPASE_CYCLE	PLEKHG1 FAM13A TRIO MCF2 ARHGEF4 FERMT2 TIAM2	2.00e-06	184	46	7	M41809
Pathway	REACTOME_RHO_GTPASE_CYCLE	PLEKHG1 FAM13A TRIO WDR81 MCF2 ARHGEF4 FERMT2 TRIP10 TIAM2	1.22e-05	450	46	9	M27078
Pathway	REACTOME_RAC1_GTPASE_CYCLE	PLEKHG1 FAM13A TRIO MCF2 FERMT2 TIAM2	2.08e-05	175	46	6	MM15599
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	TRIO MCF2 ARHGEF4 TIAM2	3.96e-05	59	46	4	M11215
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	TRIO MCF2 ARHGEF4 TIAM2	1.07e-04	76	46	4	M19832
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	TRIO MCF2 ARHGEF4 TIAM2	1.31e-04	80	46	4	M800
Pathway	REACTOME_CDC42_GTPASE_CYCLE	PLEKHG1 TRIO WDR81 MCF2 ARHGEF4	1.44e-04	155	46	5	M41808
Pathway	PID_RAC1_REG_PATHWAY	TRIO MCF2 TIAM2	2.53e-04	38	46	3	M241
Pathway	REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	TRIO MCF2 ARHGEF4 TIAM2	2.75e-04	97	46	4	M9400
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	PLEKHG1 FAM13A TRIO WDR81 MCF2 ARHGEF4 FERMT2 TRIP10 TIAM2	4.51e-04	720	46	9	M41838
Pathway	REACTOME_RHO_GTPASE_CYCLE	PLEKHG1 FAM13A TRIO MCF2 FERMT2 TRIP10 TIAM2	5.07e-04	439	46	7	MM15595
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	TRIO MCF2 TIAM2	6.43e-04	52	46	3	MM14743
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_LIGAND_GATED_CA2_CHANNEL	P2RX5 CHRNA7	6.73e-04	12	46	2	M47953
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	PSME4 TRIO TRRAP DICER1 STRIP2 STRIP1 PCNT	2.71e-07	212	71	7	33853758
Pubmed	Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae.	STRIP2 STRIP1	4.11e-06	2	71	2	12588993
Pubmed	A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation.	KDELR2 KDELR1	4.11e-06	2	71	2	25682866
Pubmed	Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation.	TENT4B TENT4A	4.11e-06	2	71	2	30026317
Pubmed	KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover.	KDELR2 KDELR1	4.11e-06	2	71	2	30760704
Pubmed	Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest.	BLM ATR	4.11e-06	2	71	2	14729972
Pubmed	The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin.	TENT4B TENT4A	4.11e-06	2	71	2	10066793
Pubmed	Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita.	TENT4B TENT4A	4.11e-06	2	71	2	32559291
Pubmed	TORC2 signaling is antagonized by protein phosphatase 2A and the Far complex in Saccharomyces cerevisiae.	STRIP2 STRIP1	4.11e-06	2	71	2	22298706
Pubmed	The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis.	TENT4B TENT4A	1.23e-05	3	71	2	35867748
Pubmed	Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression.	UBR5 DICER1	1.23e-05	3	71	2	38280476
Pubmed	The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling.	STRIP2 STRIP1	1.23e-05	3	71	2	22782902
Pubmed	A molecular specificity code for the three mammalian KDEL receptors.	KDELR2 KDELR1	1.23e-05	3	71	2	18086916
Pubmed	Genetic interaction between central pair apparatus genes CFAP221, CFAP54, and SPEF2 in mouse models of primary ciliary dyskinesia.	CFAP54 SPEF2	1.23e-05	3	71	2	32704025
Pubmed	Cell-type-specific differences in KDEL receptor clustering in mammalian cells.	KDELR2 KDELR1	1.23e-05	3	71	2	32645101
Pubmed	The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs.	STRIP2 STRIP1	1.23e-05	3	71	2	30509168
Pubmed	HAT cofactor TRRAP mediates beta-catenin ubiquitination on the chromatin and the regulation of the canonical Wnt pathway.	CUL1 TRRAP	1.23e-05	3	71	2	19066453
Pubmed	EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.	BLM ATR	1.23e-05	3	71	2	34197737
Pubmed	The dynamic organisation of the secretory pathway.	KDELR2 KDELR1	1.23e-05	3	71	2	9118249
Pubmed	Air1 zinc knuckles 4 and 5 and a conserved IWRXY motif are critical for the function and integrity of the Trf4/5-Air1/2-Mtr4 polyadenylation (TRAMP) RNA quality control complex.	TENT4B TENT4A	1.23e-05	3	71	2	21878619
Pubmed	Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing.	TENT4B TENT4A	1.23e-05	3	71	2	32451488
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	PTPRD TENT4A PUS10 SPEF2 GTF2IRD1 CCDC33	1.75e-05	265	71	6	19240061
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PLEKHG1 UBR5 ARHGEF4 STRIP2 STRIP1 DOP1B PCNT	1.99e-05	407	71	7	12693553
Pubmed	Impaired micro-RNA pathways diminish osteoclast differentiation and function.	CSF1R DICER1	2.46e-05	4	71	2	19059913
Pubmed	ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation.	BLM ATR	2.46e-05	4	71	2	15539948
Pubmed	Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain.	TRIO MCF2	2.46e-05	4	71	2	17606614
Pubmed	ATR checkpoint kinase and CRL1βTRCP collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks.	CUL1 ATR	4.09e-05	5	71	2	24700029
Pubmed	Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1.	ATR UPF2	4.09e-05	5	71	2	16086026
Pubmed	Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex.	BLM ATR	6.13e-05	6	71	2	29125140
Pubmed	STRIPAK components determine mode of cancer cell migration and metastasis.	STRIP2 STRIP1	6.13e-05	6	71	2	25531779
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	MCF2 ARHGEF4 TIAM2	6.53e-05	38	71	3	11756498
Pubmed	Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication.	ATR UPF2	8.57e-05	7	71	2	21829167
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	MCF2 ARHGEF4 TIAM2	9.49e-05	43	71	3	12376548
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	BLM CUL1 UBR5 TRRAP	9.61e-05	116	71	4	30804394
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	UBR5 ARHGEF4 DICER1 DOP1B PCNT	9.97e-05	225	71	5	12168954
Pubmed	Analysis of the sperm flagellar axoneme using gene-modified mice.	CFAP54 SPEF2	1.14e-04	8	71	2	32554934
Pubmed	Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation.	CUL1 PSME4 MED14	1.16e-04	46	71	3	31560077
Pubmed	The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.	ATR UPF2	1.47e-04	9	71	2	16488880
Pubmed	The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling.	CUL1 UBR5	1.47e-04	9	71	2	22033112
Pubmed	Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma.	UBR5 CD109	1.47e-04	9	71	2	30836988
Pubmed	Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23.	CSF1R MCF2	1.47e-04	9	71	2	1611909
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BLM FAM13A ATR MED14 GTF2IRD1 TRRAP PRDM2 STRIP1	1.79e-04	774	71	8	15302935
Pubmed	Tel2 regulates the stability of PI3K-related protein kinases.	ATR TRRAP	1.83e-04	10	71	2	18160036
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	CUL1 NEPRO UBR5 PRPF8 TRRAP DICER1 STRIP2 STRIP1 STAMBP	2.03e-04	1005	71	9	19615732
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	ATR TRRAP	2.23e-04	11	71	2	20427287
Pubmed	Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.	CUL1 TRRAP	2.23e-04	11	71	2	24349473
Pubmed	Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.	BLM ATR	2.23e-04	11	71	2	15364958
Pubmed	ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.	PRAMEF1 PRAMEF2 PCNT	2.32e-04	58	71	3	31598710
Pubmed	Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).	MCF2 ARHGEF4 TIAM2	2.57e-04	60	71	3	12787561
Pubmed	Intrinsic neural stem cell properties define brain hypersensitivity to genotoxic stress.	ATR PCNT	2.68e-04	12	71	2	35623353
Pubmed	Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.	TRIO TENT4A	2.68e-04	12	71	2	23776197
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	BLM UBR5 MED14 TRRAP TRIP10 DICER1	2.84e-04	440	71	6	34244565
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	BLM TECPR2 PUS10 YIPF4 CD109 DICER1 TIAM2 DOP1B CCDC33 PCNT	2.86e-04	1293	71	10	15342556
Pubmed	The DNA sequence of human chromosome 7.	CUL1 KDELR2 NPTX2 SAMD9 GTF2IRD1 TRRAP	2.87e-04	441	71	6	12853948
Pubmed	Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.	CUL1 PSME4 UBR5	3.40e-04	66	71	3	24811749
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	CUL1 PSME4 PIGR C11orf54 FERMT2	4.01e-04	304	71	5	32235678
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PLEKHG1 PSME4 TRIO MED14 ARHGEF4 GTF2IRD1 TRRAP TIAM2 PCNT	4.06e-04	1105	71	9	35748872
Pubmed	FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).	CUL1 ATR	4.24e-04	15	71	2	27365398
Pubmed	Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.	MED14 TRRAP	4.24e-04	15	71	2	18418385
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF1 PRAMEF2	5.48e-04	17	71	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF1 PRAMEF2	5.48e-04	17	71	2	37781892
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	UPF2 UBR5 KDELR1 MED14 PRPF8 TRRAP TRIP10	5.85e-04	704	71	7	29955894
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF1 PRAMEF2	6.16e-04	18	71	2	23894331
Pubmed	Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.	CD109 WDR81	6.16e-04	18	71	2	24068962
Pubmed	USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.	GTF2IRD1 TRRAP	6.16e-04	18	71	2	17846119
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF1 PRAMEF2	6.16e-04	18	71	2	12890732
Pubmed	Wilms Tumor Predisposition	BLM DICER1	6.16e-04	18	71	2	20301471
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF1 PRAMEF2	6.16e-04	18	71	2	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF1 PRAMEF2	6.16e-04	18	71	2	14675769
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF1 PRAMEF2	6.16e-04	18	71	2	39181896
Pubmed	A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection.	PIGR PRPF8 SERPINA12 STRIP1	6.18e-04	189	71	4	31594818
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF1 PRAMEF2	6.87e-04	19	71	2	28604677
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF1 PRAMEF2	7.62e-04	20	71	2	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF1 PRAMEF2	7.62e-04	20	71	2	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF1 PRAMEF2	7.62e-04	20	71	2	21425410
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	CUL1 ATR UBR5	7.64e-04	87	71	3	17148452
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	ATR TRIO PRPF8 DICER1	7.92e-04	202	71	4	33005030
Pubmed	ETAA1 acts at stalled replication forks to maintain genome integrity.	BLM ATR	8.41e-04	21	71	2	27723720
Pubmed	Programmed cell senescence during mammalian embryonic development.	ATR PCNT	8.41e-04	21	71	2	24238962
Pubmed	Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing.	UBR5 PRPF8	8.41e-04	21	71	2	12840015
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	MED14 WDR81 PRAMEF1 PRAMEF2 FERMT2	8.92e-04	363	71	5	14691545
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	BLM NEPRO TENT4B UPF2 MED14 PRPF8 TRRAP	9.09e-04	759	71	7	35915203
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	BLM NEPRO UBR5 PCNT	9.15e-04	210	71	4	16565220
Pubmed	Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.	CUL1 PCNT	9.24e-04	22	71	2	26631746
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF1 PRAMEF2	9.24e-04	22	71	2	31729367
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	PLEKHG1 PTPRD PUS10 RFTN2 ARHGEF4 PRAMEF1 PRAMEF2 TRRAP DOP1B	9.35e-04	1242	71	9	30973865
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF1 PRAMEF2	1.01e-03	23	71	2	19480014
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	DNHD1 PIGR C11orf54 TRIP10 TIAM2 STRIP1 STAMBP DOP1B	1.08e-03	1016	71	8	19056867
Pubmed	A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.	BLM CUL1	1.10e-03	24	71	2	16620772
Pubmed	Exploring the link between MORF4L1 and risk of breast cancer.	BLM ATR	1.10e-03	24	71	2	21466675
Pubmed	Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.	WDR81 PRPF8	1.10e-03	24	71	2	20705733
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	PTPRD TRIO CD109	1.18e-03	101	71	3	18519826
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	CUL1 KDELR2 PIGR UBR5 KDELR1 PRPF8 TRRAP STRIP1 CRB1	1.18e-03	1284	71	9	17353931
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF1 PRAMEF2	1.20e-03	25	71	2	37451217
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF1 PRAMEF2	1.20e-03	25	71	2	12620990
Pubmed	P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma.	UBR5 TRRAP	1.20e-03	25	71	2	36708875
Pubmed	The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.	UBR5 MED14 PRPF8	1.28e-03	104	71	3	31365120
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF1 PRAMEF2	1.29e-03	26	71	2	18500982
Pubmed	UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors.	KDELR2 KDELR1	1.29e-03	26	71	2	19474315
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	ATR WDR81 DICER1 CRB1	1.34e-03	233	71	4	32290105
Cytoband	1p36.21	PRAMEF1 PRAMEF2 PRDM2	1.32e-04	63	71	3	1p36.21
Cytoband	14q32.13	DICER1 SERPINA12	3.16e-04	17	71	2	14q32.13
Cytoband	17p13.3	P2RX5 WDR81 PRPF8	3.54e-04	88	71	3	17p13.3
Cytoband	3q13.2	NEPRO CD200R1	1.07e-03	31	71	2	3q13.2
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG1 TRIO MCF2 ARHGEF4 TIAM2	6.06e-07	66	45	5	722
GeneFamily	Non-canonical poly(A) polymerases	TENT4B TENT4A	1.26e-04	7	45	2	1318
GeneFamily	Protein phosphatase catalytic subunits\|STRIPAK complex	STRIP2 STRIP1	1.12e-03	20	45	2	1371
GeneFamily	PRAME family	PRAMEF1 PRAMEF2	1.61e-03	24	45	2	686
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG1 ARHGEF4 FERMT2 TIAM2	1.69e-03	206	45	4	682
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	P2RX5 TRIP10	7.15e-03	51	45	2	870
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	BLM CUL1 PSME4 ATR UPF2 TRIO UBR5 FERMT2 TRRAP DICER1 DOP1B PCNT	2.97e-06	856	71	12	M4500
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	BLM CUL1 ATR UPF2 TRIO UBR5 FERMT2 TRRAP DOP1B	4.61e-06	466	71	9	M13522
ToppCell	10x5'-bone_marrow-Lymphocytic_B-Memory_B_cells\|bone_marrow / Manually curated celltypes from each tissue	DENND5B PLEKHG1 P2RX5 UPF2 RNASET2 PRDM2	6.16e-07	191	71	6	67479df0ca4c5a792fd604aded3f75609fec0888
ToppCell	mild_COVID-19-B_cell\|mild_COVID-19 / disease group, cell group and cell class (v2)	DENND5B PLEKHG1 P2RX5 PIGR TTC39A	2.25e-06	132	71	5	4b372483bc106aecc7b96a09131e1695e54e7dc4
ToppCell	mild_COVID-19-B_cell\|World / disease group, cell group and cell class (v2)	DENND5B PLEKHG1 P2RX5 PIGR TTC39A	3.33e-06	143	71	5	4698cc877dda9b1ef7d6f18c9adc869ef791b1d8
ToppCell	mild_COVID-19_(asymptomatic)-B_intermediate\|World / disease group, cell group and cell class (v2)	DENND5B PLEKHG1 P2RX5 UPF2 PRDM2	5.75e-06	160	71	5	6722934e153b72039c3c4308557d0ef879a30638
ToppCell	10x5'-bone_marrow-Lymphocytic_B-ABC_aged-B_memory\|bone_marrow / Manually curated celltypes from each tissue	DENND5B MACC1 P2RX5 PIGR PRDM2	6.49e-06	164	71	5	746833f74095c0f25ce76baf1069f1848c231933
ToppCell	mild_COVID-19_(asymptomatic)-B_intermediate\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	DENND5B MACC1 P2RX5 UPF2 PRDM2	6.88e-06	166	71	5	8de8f388f24436b84e19ef460476fdbda4d16abf
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-10\|TCGA-Brain / Sample_Type by Project: Shred V9	CFAP47 CFAP54 SPEF2 CD109 CCDC33	7.95e-06	171	71	5	74be8d3bf6b99e2d734635a8b1a7c41e8c596959
ToppCell	facs-Trachea-3m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell-ciliated_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFAP47 CFAP54 SPEF2 SERPINA12 CCDC33	9.40e-06	177	71	5	3cfde67b93f3986312f5e74e42504214d966e7dc
ToppCell	facs-Trachea-3m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFAP47 CFAP54 SPEF2 SERPINA12 CCDC33	9.40e-06	177	71	5	12a52a12a87a31e501ced611f46a90d172ca7e35
ToppCell	CTRL-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	DENND5B PLEKHG1 MACC1 TRIO PRDM2	1.29e-05	189	71	5	14f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLEKHG1 P2RX5 UPF2 TRIO PRDM2	1.32e-05	190	71	5	0db545a4cba7534bad2693e0d565cde7dbc7a586
ToppCell	COPD-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	DENND5B PLEKHG1 UPF2 TRIO PRDM2	1.32e-05	190	71	5	1e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCell	CF-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	PLEKHG1 MACC1 TRIO TIAM2 PRDM2	1.43e-05	193	71	5	7ebf20344a9a154fd2cffa281526867fcf0aded3
ToppCell	severe_COVID-19-B_intermediate\|World / disease group, cell group and cell class (v2)	DENND5B PLEKHG1 P2RX5 UPF2 PRDM2	1.46e-05	194	71	5	cb346cb186fe80a8f490ae90b2539b3543ba0ca9
ToppCell	severe_COVID-19-B_intermediate\|severe_COVID-19 / disease group, cell group and cell class (v2)	DENND5B PLEKHG1 P2RX5 UPF2 PRDM2	1.58e-05	197	71	5	3ba64850b344cb24a4d20d64392a0b2752950d40
ToppCell	(5)_Dendritic_cell-(53)_Lymphoid_DC\|(5)_Dendritic_cell / shred on Cell_type and subtype	PLEKHG1 NTS CHRNA7 TIAM2 STRIP2	1.61e-05	198	71	5	548da5fa86f9756c503ed77bcdde55bc4d1a2726
ToppCell	severe-B_memory\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DENND5B PLEKHG1 P2RX5 UPF2 PRDM2	1.61e-05	198	71	5	88649dc642193bda5e8eff3f79c832807d5e200a
ToppCell	MS-IIF-Lymphocyte-B-B_intermediate\|IIF / Disease, condition lineage and cell class	DENND5B PLEKHG1 P2RX5 RNASET2 PRDM2	1.61e-05	198	71	5	d6b533c5e1d55e13b1e87ce3dbacb1564bcdcc64
ToppCell	mild-B_intermediate\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DENND5B PLEKHG1 P2RX5 UPF2 PRDM2	1.69e-05	200	71	5	fe815824e9e4be3f3db73610e3814a7fd533da65
ToppCell	PCW_05-06-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CFAP47 MACC1 CFAP54 MCF2	7.42e-05	140	71	4	8abbd5dc799943b49cd0045d0da405c3f3d0db6b
ToppCell	PCW_05-06-Epithelial-Epithelial_ciliated\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CFAP47 MACC1 CFAP54 MCF2	7.42e-05	140	71	4	e4689232c473d239b07a7fbcaaa3414fbd9badea
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-Z\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CSF1R PIGR RNASET2 CCDC168	7.84e-05	142	71	4	f720f13b339589fa924a42e89393e5db0b26300b
ToppCell	PND01-03-samps-Epithelial-Epithelial-non_alveolar\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	CFAP47 CFAP54 SPEF2 CCDC33	1.05e-04	153	71	4	fc0d2d50aa3b6b2772bbf3626c9df5c5e8d7d11e
ToppCell	18-Airway-Epithelial-Goblet-like_secretory\|Airway / Age, Tissue, Lineage and Cell class	PIGR MED14 TTC39A CHRNA7	1.05e-04	153	71	4	14a60220e169ce642771636de982a7b02e5b2608
ToppCell	PND01-03-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	CFAP47 CFAP54 SPEF2 CCDC33	1.05e-04	153	71	4	2482247d9c39c7b99bb45fb9153442f64fd6012f
ToppCell	ileum-BEST4+_Enterocytes\|ileum / shred on tissue and cell subclass	SAMD9 FAM13A PIGR ALG9	1.07e-04	154	71	4	608e9c982125e0c2c15b86b1920813845a0db81f
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLEKHG1 P2RX5 TRIO PRDM2	1.34e-04	163	71	4	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_naive-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	DENND5B PLEKHG1 SAMD9 P2RX5	1.40e-04	165	71	4	8003fd2aa3f5c9d0e99054af4ad2d79a4a3c4829
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DENND5B PLEKHG1 P2RX5 TRIO	1.40e-04	165	71	4	fead3f2032f8fa5f7f0159a4434989b3d65debbb
ToppCell	356C-Myeloid-Dendritic-cDC_activated\|356C / Donor, Lineage, Cell class and subclass (all cells)	TRIP10 CHRNA7 TIAM2 STRIP2	1.47e-04	167	71	4	43a9375fdbafd7450c553e4620e21537e08639dd
ToppCell	Control-B_cells-Activated_B_cells\|Control / group, cell type (main and fine annotations)	DENND5B PLEKHG1 P2RX5 PRDM2	1.50e-04	168	71	4	a7159a35fe37f8c241cf8d391debe271e0698105
ToppCell	Int-URO-Lymphocyte-B-B_intermediate\|Int-URO / Disease, Lineage and Cell Type	DENND5B P2RX5 PIGR RFTN2	1.50e-04	168	71	4	5b3fb1fc8fea810c6d4e6feb42c24fb57e8066de
ToppCell	facs-Marrow-T_cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCF2 ARHGEF4 SERPINA12 STRIP2	1.53e-04	169	71	4	2a35846b0e0be0a19a5a04a86cbd72ce65257c8a
ToppCell	356C-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	PLEKHG1 TRIP10 CHRNA7 TIAM2	1.53e-04	169	71	4	44d201361eb497222a4972a0e10bac1e05dcfd0a
ToppCell	356C-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	PLEKHG1 TRIP10 CHRNA7 TIAM2	1.57e-04	170	71	4	513d9036aa41d4d902da8baa66a66206abb6f3b0
ToppCell	368C-Lymphocytic-ILC\|368C / Donor, Lineage, Cell class and subclass (all cells)	SRRD P2RX5 CD200R1 DOP1B	1.60e-04	171	71	4	3b3143e4aa6520ee9c6b6f2482206ad3d8205d14
ToppCell	3'_v3-Lung-Lymphocytic_B-Memory_B_cells\|Lung / Manually curated celltypes from each tissue	DENND5B PLEKHG1 P2RX5 PRDM2	1.60e-04	171	71	4	9ecef653f6916572bf5fbee5aea6c577d04e96ba
ToppCell	368C-Lymphocytic-ILC-ILC-2\|368C / Donor, Lineage, Cell class and subclass (all cells)	SRRD P2RX5 CD200R1 DOP1B	1.60e-04	171	71	4	fd01076574dcc82bfd4a1538812500543b16794f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLEKHG1 P2RX5 PRDM2 CD200R1	1.60e-04	171	71	4	a2938e56cb5749004317798dc7ac0f0c2d4d8ae0
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DENND5B PLEKHG1 P2RX5 PRDM2	1.64e-04	172	71	4	62ed3b70fa1f6c84ea80ff00f60d2562be292e9d
ToppCell	PND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TECPR2 NTS KDELR1 RFTN2	1.68e-04	173	71	4	03b50b2376d353748a32bf14a9fc8341ea61dbca
ToppCell	PND28-Endothelial-Endothelial_lymphatic\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TECPR2 NTS KDELR1 RFTN2	1.68e-04	173	71	4	2978c744d3c8dcaa2b9bb225abf846f82e8f9176
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLEKHG1 P2RX5 TRIO PRDM2	1.68e-04	173	71	4	d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell	PND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TECPR2 NTS KDELR1 RFTN2	1.68e-04	173	71	4	12da47b90aecedaa31764ff7ddb853ee39123e9d
ToppCell	PND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TECPR2 NTS KDELR1 RFTN2	1.68e-04	173	71	4	23d4a315a0ad5c6fc77bcfc18b6c1ff55be99e8f
ToppCell	droplet-Lung-nan-18m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLM TECPR2 TTC39A STRIP2	1.68e-04	173	71	4	20a20429aa898097d5ec4880ed64846558b5890f
ToppCell	PND07-28-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	CFAP47 CFAP54 SPEF2 CCDC33	1.72e-04	174	71	4	f41d05a3703d7092bd3c4a97c15ae13069aaa4ad
ToppCell	Healthy_Control-Myeloid-Mast\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	P2RX5 FERMT2 CHRNA7 STRIP2	1.75e-04	175	71	4	ca187074adcc9b8bd0fa270e2ede1564c8e6c6cf
ToppCell	IIF-Lymphocyte-B-B_intermediate\|IIF / Disease, Lineage and Cell Type	DENND5B PLEKHG1 P2RX5 PRDM2	1.75e-04	175	71	4	327f8ee3669c3fc5ba50abc3b4f3e068637fd8d8
ToppCell	Healthy_Control-Myeloid-Mast-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	P2RX5 FERMT2 CHRNA7 STRIP2	1.75e-04	175	71	4	eadbbcdf2aef4cee268bc70a7a2c4175d898953b
ToppCell	PND07-28-samps-Epithelial-Epithelial-non_alveolar\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	CFAP47 CFAP54 SPEF2 CCDC33	1.75e-04	175	71	4	c01a15b2084da4a18f8ff3623f44eb9dfe499f10
ToppCell	390C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	NPTX2 PARP16 TTC39A PRPF8	1.79e-04	176	71	4	aab9603b7943b7f7243eb6190ebba998566196f3
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 CFAP54 SPEF2 CCDC33	1.83e-04	177	71	4	e8bb4f8ecd5e283efec966b9fc2040a6152d5551
ToppCell	COVID-19-B_cells-Activated_B_cells\|COVID-19 / group, cell type (main and fine annotations)	DENND5B PLEKHG1 P2RX5 PRDM2	1.83e-04	177	71	4	653bb62a3744d4024ab3186ee01d410ed62832a6
ToppCell	390C-Lymphocytic-B_cell-\|390C / Donor, Lineage, Cell class and subclass (all cells)	DENND5B P2RX5 RNASET2 PRDM2	1.87e-04	178	71	4	02cb514096435a4d8c84f0cc12ae627db319621d
ToppCell	390C-Lymphocytic-B_cell\|390C / Donor, Lineage, Cell class and subclass (all cells)	DENND5B P2RX5 RNASET2 PRDM2	1.87e-04	178	71	4	9af29e341087ba4dd3ef246cdbae6469ea9de15f
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-0\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DENND5B P2RX5 PIGR PRDM2	1.87e-04	178	71	4	be1d991c5a0a5be22f14f57d34ee1330f1a12963
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MACC1 P2RX5 TTC39A STRIP2	1.87e-04	178	71	4	0b456ac768e026c3ecd5a9a4f43d6f126e7685a1
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 CFAP54 SPEF2 CCDC33	1.87e-04	178	71	4	b1db59344c074c7c80169fc2c5cd5fc89f3fe463
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 CFAP54 SPEF2 CCDC33	1.87e-04	178	71	4	579cdc14f28b459e200ae2102e0bd4df8a2c0dcb
ToppCell	ILEUM-non-inflamed-(5)_Plasma-(5)_IgM_plasma_cells\|(5)_Plasma / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	UPF2 FERMT2 CRB1	1.91e-04	70	71	3	aa63c1b77a9fb15e75835cb3781f2d890f3fe328
ToppCell	3'_v3-Lung-Lymphocytic_B\|Lung / Manually curated celltypes from each tissue	DENND5B PLEKHG1 P2RX5 PRDM2	1.95e-04	180	71	4	237a2130a3f48595dad2417539c21e44585962b8
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B-B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND5B PLEKHG1 P2RX5 PRDM2	1.99e-04	181	71	4	8d8cc4dae2c8bd5f4b1c159f2a52edc4c9449c86
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	PLEKHG1 ADPRH PIGR TENT4A	2.04e-04	182	71	4	21744c9c792e57d5d41b25986f419b2358c7057b
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DENND5B P2RX5 TIAM2 PRDM2	2.04e-04	182	71	4	5f1f10c845b73d1f69794277925ef847ff23ac2d
ToppCell	COPD-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	DENND5B CFAP54 TRIO PARP16	2.04e-04	182	71	4	19db653fe04c5e2957eea1f4893b1c1fca4ddcbd
ToppCell	normal-na-Lymphocytic_B-B_mem-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	DENND5B PLEKHG1 P2RX5 PRDM2	2.04e-04	182	71	4	ee36ea6cb9a5a08aeb83f2b7a249255f0b1a9870
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MACC1 FAM13A PIGR TTC39A	2.04e-04	182	71	4	17ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DENND5B PLEKHG1 P2RX5 PIGR	2.08e-04	183	71	4	01664fce6b70a02c9d39d747b6a6aabc86d57bc2
ToppCell	nucseq-Immune-Lymphocytic_B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND5B PLEKHG1 P2RX5 PRDM2	2.12e-04	184	71	4	911658e7bb499c1bbc8419eec8ff88729bc39a75
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND5B PLEKHG1 P2RX5 PRDM2	2.12e-04	184	71	4	942b58ae7172bb5f97e55b032db9329d161854af
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MACC1 FAM13A PIGR TTC39A	2.12e-04	184	71	4	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DENND5B P2RX5 TIAM2 PRDM2	2.17e-04	185	71	4	e913c64f9b4873443d88dce270f0b7b6d1b4cbce
ToppCell	343B-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PSME4 SPEF2 CD109 WDR81	2.17e-04	185	71	4	1b8e3ddb91797f84e4b15d2457b0c008e5be50db
ToppCell	343B-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PSME4 SPEF2 CD109 WDR81	2.17e-04	185	71	4	02cbf492bc40abebaa93a3a208888afae72fbe06
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MACC1 FAM13A PIGR TTC39A	2.17e-04	185	71	4	fefaf227d89f680d6f3e91c4a94e26ab4d0dc6c3
ToppCell	COPD-Lymphoid-B\|COPD / Disease state, Lineage and Cell class	DENND5B PLEKHG1 UPF2 PRDM2	2.17e-04	185	71	4	925e79c35c381dd44ec5fb921dca09ce43140135
ToppCell	COPD-Lymphoid-B\|World / Disease state, Lineage and Cell class	DENND5B PLEKHG1 UPF2 PRDM2	2.17e-04	185	71	4	22891ed75e25ef30dfa541cb82d85e08ce07e7d9
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DENND5B P2RX5 TIAM2 PRDM2	2.21e-04	186	71	4	1a1e5d85a5ad90afee234c12a9b54a5e93a8a2f2
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DENND5B P2RX5 TIAM2 PRDM2	2.21e-04	186	71	4	f1366638edaecad5cad6367440f4c693513bed7e
ToppCell	droplet-Lung-nan-21m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHG1 P2RX5 MCF2 CD200R1	2.21e-04	186	71	4	f1aa0c58336d23bcbe52a59e7af954d20085bdb6
ToppCell	droplet-Lung-nan-21m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHG1 P2RX5 MCF2 CD200R1	2.21e-04	186	71	4	8f77e552e613b6e124443c7f6ef5c1316a5ff8db
ToppCell	Control-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	DENND5B CFAP54 TRIO PARP16	2.21e-04	186	71	4	a08a50bff4e629588faa22440d57334b1df0e8df
ToppCell	10x5'v1-week_12-13-Myeloid_macrophage-stroma-osteoclast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	CSF1R CD109 RFTN2 STRIP2	2.21e-04	186	71	4	c9dfcf7bba7e5ef97ad5d9b7084fba932c91ab68
ToppCell	lymphoid-B_cell-Naive_B_cell\|World / Lineage, cell class and subclass	DENND5B PLEKHG1 P2RX5 PRDM2	2.26e-04	187	71	4	904ffd8cf4513e86fcd4c2b7faf24a34fbd2dce3
ToppCell	Control-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	DENND5B PLEKHG1 TRIO PRDM2	2.26e-04	187	71	4	4e64be635f445276e71f2937f33f041c3a4204ab
ToppCell	IPF-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	DENND5B PLEKHG1 TRIO PRDM2	2.26e-04	187	71	4	af1327559f7e01bec070881cae52834917c3da65
ToppCell	lymphoid-B_cell\|World / Lineage, cell class and subclass	DENND5B PLEKHG1 P2RX5 PRDM2	2.26e-04	187	71	4	2abbc01fd7f5b4e52113699625287893c991f8da
ToppCell	PND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFAP54 SPEF2 TTC39A CCDC33	2.35e-04	189	71	4	057d7a03fdbe779122b203619a6f947f49b84d28
ToppCell	COVID-19-lung-Ciliated\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CFAP47 CFAP54 SPEF2 CCDC33	2.35e-04	189	71	4	a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCell	PND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFAP54 SPEF2 TTC39A CCDC33	2.35e-04	189	71	4	9f57a131902d23494bf389baf6e6e2d99f88b2c8
ToppCell	COVID-19-lung-Ciliated\|lung / Disease (COVID-19 only), tissue and cell type	CFAP47 CFAP54 SPEF2 CCDC33	2.35e-04	189	71	4	27329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCell	PND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFAP54 SPEF2 TTC39A CCDC33	2.35e-04	189	71	4	e443b02502edaefa94567a9e8af5756e8e11ff30
ToppCell	390C-Lymphocytic-B_cell-\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DENND5B P2RX5 RNASET2 PRDM2	2.40e-04	190	71	4	f63c9474f23bb72f0bb1fc531342f0da04ed8b3e
ToppCell	COVID-19_Severe-Lymphoid_B-B_memory\|COVID-19_Severe / Disease group, lineage and cell class	DENND5B PLEKHG1 P2RX5 TIAM2	2.40e-04	190	71	4	b6510c419a15ed049c0a0a6a6697b643668741c3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BLM PLEKHG1 NPTX2 CD109	2.40e-04	190	71	4	31de1727822e9818652946dfb962daee77ffad68
ToppCell	COVID_vent-Lymphocytic-B_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	DENND5B PLEKHG1 P2RX5 TRIO	2.40e-04	190	71	4	40b5e9e8f8fd8d84cb5b43e67b49267082348e9f
ToppCell	COVID_vent-Lymphocytic-B_cell-\|COVID_vent / Disease condition, Lineage, Cell class and subclass	DENND5B PLEKHG1 P2RX5 TRIO	2.40e-04	190	71	4	a37a32dc1b931562a6660074e19d5598efc65284
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DENND5B PLEKHG1 P2RX5 PRDM2	2.40e-04	190	71	4	a7498fe55b7810c482291db782dc5282675d246a
ToppCell	390C-Lymphocytic-B_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DENND5B P2RX5 RNASET2 PRDM2	2.40e-04	190	71	4	53bf211f0e8a44f5adb89c43b210a1e35120b6a8
Disease	Seckel syndrome 1	ATR PCNT	1.52e-05	3	67	2	C4551474
Disease	lung cancer (is_implicated_in)	CSF1R ATR RNASET2 CHRNA7	2.48e-05	74	67	4	DOID:1324 (is_implicated_in)
Disease	colon adenocarcinoma (is_implicated_in)	CSF1R UBR5 RNASET2	2.80e-05	26	67	3	DOID:234 (is_implicated_in)
Disease	Malignant Neoplasms	BLM CSF1R ATR DICER1	2.10e-04	128	67	4	C0006826
Disease	Tobacco Dependence	PLEKHG1 CHRNA7	4.54e-04	14	67	2	C0040332
Disease	Nicotine Dependence	PLEKHG1 CHRNA7	4.54e-04	14	67	2	C0028043
Disease	Nicotine Use Disorder	PLEKHG1 CHRNA7	4.54e-04	14	67	2	C0376384
Disease	MYELODYSPLASTIC SYNDROME	BLM SAMD9 CSF1R	4.83e-04	67	67	3	C3463824
Disease	Benign neoplasm of stomach	ATR UBR5	6.76e-04	17	67	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	ATR UBR5	6.76e-04	17	67	2	C0496905
Disease	Carcinoma in situ of stomach	ATR UBR5	6.76e-04	17	67	2	C0154060
Disease	Chronic myeloproliferative disorder	ATR PCNT	8.47e-04	19	67	2	C1292778
Disease	Stomach Carcinoma	ATR UBR5	1.04e-03	21	67	2	C0699791
Disease	Seckel syndrome	ATR PCNT	1.14e-03	22	67	2	C0265202
Disease	Brain Diseases	RNASET2 STAMBP	1.47e-03	25	67	2	C0006111
Disease	Encephalopathies	RNASET2 STAMBP	1.72e-03	27	67	2	C0085584
Disease	retinitis pigmentosa (implicated_via_orthology)	PRPF8 CRB1	1.72e-03	27	67	2	DOID:10584 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VLLLYAYNLKPLKIS	CFAP54	2951	Q96N23
VVVLLYYIRSKVKLP	CXorf65	21	A6NEN9
KQELLSYKIPIKYLR	CCDC33	321	Q8N5R6
YALKTLYPIIGKRLK	ABCD2	31	Q9UBJ2
YVNYTILKPRKAKQI	ALG9	591	Q9H6U8
KNLSKLLPQYLEIYI	ADAM18	176	Q9Y3Q7
KICKYPLQLAELLKY	ARHGEF4	426	Q9NR80
LKQLPKQNKLYLQLY	DNHD1	1481	Q96M86
KVIKLLEILRKYKPY	DICER1	376	Q9UPY3
QRKLYKELVKNYNPL	CHRNA7	26	P36544
YLYRVVLLRLKLSPK	RFTN2	96	Q52LD8
PLTKIQTLKYTIKYI	MSGN1	161	A6NI15
TKKYPVLPYLVLVLK	TENT4B	251	Q8NDF8
LTLYEKYFLPLQKLL	DOP1B	126	Q9Y3R5
GAKKSAKLYIPYIIL	CD200R1	236	Q8TD46
YKYLLQLPGKQVRTK	GGPS1	16	O95749
IVKEVYYKNSLPILL	FAM13A	251	O94988
RKALIYQKKYLLLLI	PCNT	3146	O95613
MKKYSLLPYLILVLK	TENT4A	351	Q5XG87
NKLFIKLTRLPQYYI	MED14	536	O60244
QLLRVKYLLVYSQKP	PARP16	261	Q8N5Y8
KRKIPYILKRQLYEN	NTS	141	P30990
PYKLPYKELLNELQK	PUS10	36	Q3MIT2
LRPILTKLYKEKGVY	ATR	2386	Q13535
PNIYILDYLTKKKQL	CD109	931	Q6YHK3
LLLLLLLYKYKQKPK	CSF1R	531	P07333
LQLSKKDPIIKLLYV	BLM	751	P54132
DTLIKLYLGYKNKKL	CUL1	666	Q13616
IKLYNQKYPGLLKII	GALNT8	236	Q9NY28
LLSNQPLTKKLYKRY	DENND5B	886	Q6ZUT9
LEQIVLPLKKLTYIY	MACC1	636	Q6ZN28
SYLLKPVQRITKYQL	MCF2	626	P10911
LPYVKNYSRKQLVKV	CCDC168	551	Q8NDH2
YLYITKVLKGKKLSL	KDELR1	196	P24390
ISLKIKPYKIELYQS	CRB1	796	P82279
LVSPRYLKKYKNKQI	FERMT2	521	Q96AC1
LGIKYPVQVPYKRIK	GTF2IRD1	721	Q9UHL9
LKCKPYQILYVDLKL	CFAP47	2156	Q6ZTR5
YLYITKVLKGKKLSL	KDELR2	196	P33947
LHLSYLLYKKRPVKI	BVES	106	Q8NE79
LEINRAIYYKTLKPI	PRDM2	116	Q13029
NIKGYYIIIVPLKKS	PTPRD	1136	P23468
KKRPPLQEYVRKLLY	UPF2	766	Q9HAU5
YVIAKNKKVGLLYRL	P2RX5	21	Q93086
LLYQLYIALQKKKKS	SPEF2	96	Q9C093
QLYVLKLLKLQTKYL	STRIP2	706	Q9ULQ0
YKLALKNYIPYLTKL	SAMD9	1246	Q5K651
LYKGVLKRLILLYEP	NEPRO	186	Q6NW34
LYVLKLLKVQTKYLG	STRIP1	711	Q5VSL9
VNYLTPIKYLRKSLK	PRAMEF1	186	O95521
PIKYLRKSLKIIYLN	PRAMEF1	191	O95521
VNYLTPIKYLRKSLK	PRAMEF2	186	O60811
PIKYLRKSLKIIYIN	PRAMEF2	191	O60811
LRTNYLYGKIKKTLP	NPTX2	231	P47972
LLKKKYPLAKYLCVL	SLC35B1	131	P78383
PLVVKIDKPYLLLIY	SERPINA12	381	Q8IW75
GKAPKLTQLYYLLAK	ADPRH	71	P54922
AYAKQLRSLVKKYLP	TRIP10	41	Q15642
PYLLPLVNQKKVYDL	C11orf54	66	Q9H0W9
GYTYILPKNVLKKFI	PRPF8	2101	Q6P2Q9
LLKLGIKPSINYYQV	RNASET2	151	O00584
LESYLIKPVQRVLKY	TIAM2	1241	Q8IVF5
ILYNKYITLFIEKLP	STAMBP	61	O95630
LQKNYPYIAKILKGL	SRRD	261	Q9UH36
LYYLLNAIPTKIQKG	TECPR2	16	O15040
KRKSLYKQIGLYPVL	PIGR	161	P01833
LLKYLEPKLTQVYKN	PSME4	1486	Q14997
TKKPLLIYPIFLLYI	YIPF4	221	Q9BSR8
LGSYLLKPVQRILKY	PLEKHG1	241	Q9ULL1
KKIKYDHYLIPNALL	TTC39A	536	Q5SRH9
LQPKETQIYIKLVKY	TRRAP	581	Q9Y4A5
KNANKYLLKPLIGAY	WDR81	956	Q562E7
YLIKPVQRITKYQLL	TRIO	1421	O75962
RLYVPLYSSKQILKQ	UBR5	2771	O95071