Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	costamere	AHNAK CMYA5 AHNAK2	2.29e-05	22	53	3	GO:0043034
GeneOntologyCellularComponent	nuclear body	NELFE TCF20 YLPM1 NUFIP2 ACIN1 ZFHX3 CMYA5 TERF2 TP53 EFTUD2	7.74e-05	903	53	10	GO:0016604
HumanPheno	Decreased eosinophil count	CDH23 CARD10 TP53	3.07e-06	9	18	3	HP:0031891
Domain	CS	NUDCD3 CHORDC1	7.30e-04	14	54	2	PF04969
Domain	Znf_FYVE_PHD	KMT2D TCF20 PCLO SYTL2	8.58e-04	147	54	4	IPR011011
Domain	PDZ	AHNAK PCLO PARD3B AHNAK2	9.48e-04	151	54	4	PS50106
Domain	CS_dom	NUDCD3 CHORDC1	9.59e-04	16	54	2	IPR007052
Domain	CS	NUDCD3 CHORDC1	9.59e-04	16	54	2	PS51203
Domain	PDZ	AHNAK PCLO PARD3B AHNAK2	9.72e-04	152	54	4	IPR001478
Domain	HSP70_2	HSPA12A HYOU1	1.09e-03	17	54	2	PS00329
Domain	HSP70_3	HSPA12A HYOU1	1.09e-03	17	54	2	PS01036
Domain	HSP70_1	HSPA12A HYOU1	1.09e-03	17	54	2	PS00297
Domain	Hsp_70_fam	HSPA12A HYOU1	1.22e-03	18	54	2	IPR013126
Domain	EPHD	KMT2D TCF20	1.83e-03	22	54	2	PS51805
Domain	SH3_2	SH3PXD2B SASH1 MYO15A	1.97e-03	86	54	3	IPR011511
Domain	SH3_2	SH3PXD2B SASH1 MYO15A	1.97e-03	86	54	3	PF07653
Domain	-	NUDCD3 CHORDC1	2.00e-03	23	54	2	2.60.40.790
Domain	HSP20-like_chaperone	NUDCD3 CHORDC1	2.55e-03	26	54	2	IPR008978
Domain	C2	PCLO SYTL2 FER1L6	6.44e-03	131	54	3	PF00168
Domain	C2	PCLO SYTL2 FER1L6	7.29e-03	137	54	3	SM00239
Domain	PDZ	AHNAK PARD3B AHNAK2	7.89e-03	141	54	3	PF00595
Domain	C2	PCLO SYTL2 FER1L6	8.04e-03	142	54	3	PS50004
Domain	PDZ	AHNAK PARD3B AHNAK2	9.00e-03	148	54	3	SM00228
Domain	-	PCLO SYTL2 FER1L6	9.00e-03	148	54	3	2.60.40.150
Domain	SANT	ZSCAN20 TERF2	9.20e-03	50	54	2	SM00717
Domain	-	AHNAK PARD3B AHNAK2	9.34e-03	150	54	3	2.30.42.10
Domain	SANT/Myb	ZSCAN20 TERF2	9.92e-03	52	54	2	IPR001005
Domain	SCAN	ZSCAN20 PGBD1	1.14e-02	56	54	2	SM00431
Pathway	REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION	ZFHX3 TP53	6.53e-05	6	30	2	MM15534
Pathway	REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION	ZFHX3 TP53	9.13e-05	7	30	2	M27807
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NELFE SH3PXD2B KMT2D TCF20 PRRC2C AHNAK BAG3 YLPM1 NUFIP2 PDCD11 ACIN1 ARHGAP35 CHORDC1 TP53	1.22e-13	549	55	14	38280479
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	NELFE PRRC2C AHNAK BAG3 YLPM1 NUFIP2 ACIN1 NUDCD3 ARHGAP35 TP53 AHNAK2 EFTUD2	1.99e-08	934	55	12	33916271
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NELFE FSIP2 SH3PXD2B TCF20 SASH1 PRRC2C AHNAK BAG3 PARD3B TP53 AHNAK2	8.90e-08	861	55	11	36931259
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	NELFE SH3PXD2B HYOU1 PRRC2C AHNAK YLPM1 NUFIP2 ARHGAP35 WASHC2A AHNAK2	1.81e-07	724	55	10	36232890
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	FSIP2 PRRC2C AHNAK BAG3 YLPM1 NUFIP2 ACIN1 TP53	2.13e-07	399	55	8	35987950
Pubmed	UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.	SH3PXD2B AHNAK BAG3 NUFIP2 NUDCD3 CHORDC1 WASHC2A	2.15e-07	267	55	7	33417871
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	NELFE RSBN1 TCF20 PRRC2C AHNAK YLPM1 NUFIP2 PDCD11 ACIN1 TP53 EFTUD2	2.48e-07	954	55	11	36373674
Pubmed	The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression.	PRRC2C NUFIP2 CHORDC1 WASHC2A TP53	4.74e-07	97	55	5	37151849
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	HYOU1 TCF20 PRRC2C AHNAK YLPM1 NUFIP2 PDCD11 ACIN1 TP53	8.08e-07	653	55	9	22586326
Pubmed	Characterization of the zinc-induced Shank3 interactome of mouse synaptosome.	HYOU1 TCF20 CDH23 ZFHX3 MYO15A	8.46e-07	109	55	5	29111324
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	NELFE RSBN1 KMT2D TCF20 YLPM1 NUFIP2 ACIN1	1.11e-06	341	55	7	32971831
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	SH3PXD2B HYOU1 AHNAK NAB2 BAG3 YLPM1 PDCD11 ACIN1 NUDCD3 CHORDC1 AHNAK2 EFTUD2	1.19e-06	1367	55	12	32687490
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	KMT2D TCF20 YLPM1 ACIN1 ZFHX3 EFTUD2	1.34e-06	220	55	6	35785414
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	FSIP2 TCF20 PRRC2C TP53 AHNAK2	1.54e-06	123	55	5	26912792
Pubmed	Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases.	KMT2D TP53	2.46e-06	2	55	2	32697937
Pubmed	Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis.	KMT2D ZBTB32	2.46e-06	2	55	2	15542853
Pubmed	KMT2D mutations and TP53 disruptions are poor prognostic biomarkers in mantle cell lymphoma receiving high-dose therapy: a FIL study.	KMT2D TP53	2.46e-06	2	55	2	31537689
Pubmed	The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells.	AHNAK AHNAK2	2.46e-06	2	55	2	15007166
Pubmed	Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imaging.	CMYA5 TP53	2.46e-06	2	55	2	16885345
Pubmed	Prognostic effect of coexisting TP53 and ZFHX3 mutations in non-small cell lung cancer patients treated with immune checkpoint inhibitors.	ZFHX3 TP53	2.46e-06	2	55	2	35226388
Pubmed	Regulation of p53 target gene expression by peptidylarginine deiminase 4.	PADI4 TP53	2.46e-06	2	55	2	18505818
Pubmed	An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.	PADI4 TP53	2.46e-06	2	55	2	37140445
Pubmed	BAG3 interacts with p53 in endometrial carcinoma.	BAG3 TP53	2.46e-06	2	55	2	32578139
Pubmed	Molecular and cellular basis of mammary gland fibrosis and cancer risk.	TERF2 TP53	2.46e-06	2	55	2	30450584
Pubmed	Regulation of histone modification and chromatin structure by the p53-PADI4 pathway.	PADI4 TP53	2.46e-06	2	55	2	22334079
Pubmed	AHNAK1 and AHNAK2 are costameric proteins: AHNAK1 affects transverse skeletal muscle fiber stiffness.	AHNAK AHNAK2	2.46e-06	2	55	2	20833135
Pubmed	KMT2D and TP53 mutation status improve the prognostic value of the International Prognostic Index (IPI) stratification in ENKTL patients.	KMT2D TP53	2.46e-06	2	55	2	32064880
Pubmed	Telomere DNA Damage Signaling Regulates Prostate Cancer Tumorigenesis.	TERF2 TP53	2.46e-06	2	55	2	32467172
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	NELFE TCF20 AHNAK BAG3 YLPM1 NUFIP2 PDCD11 ACIN1 ISG20L2 EFTUD2	3.03e-06	989	55	10	36424410
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	NELFE KMT2D TCF20 BAG3 YLPM1 ACIN1 ARHGAP35 TERF2 EFTUD2	3.25e-06	774	55	9	15302935
Pubmed	Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2.	TERF2 TP53	7.36e-06	3	55	2	18451109
Pubmed	Dysfunctional mammalian telomeres join with DNA double-strand breaks.	TERF2 TP53	7.36e-06	3	55	2	15010310
Pubmed	Citrullination of inhibitor of growth 4 (ING4) by peptidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53.	PADI4 TP53	7.36e-06	3	55	2	21454715
Pubmed	Coordination of PAD4 and HDAC2 in the regulation of p53-target gene expression.	PADI4 TP53	7.36e-06	3	55	2	20190809
Pubmed	MicroRNA-18a modulates P53 expression by targeting IRF2 in gastric cancer patients.	IRF2 TP53	7.36e-06	3	55	2	26173586
Pubmed	Self-regulated alternative splicing at the AHNAK locus.	AHNAK AHNAK2	7.36e-06	3	55	2	21940993
Pubmed	KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition.	KMT2D TP53	7.36e-06	3	55	2	37142882
Pubmed	Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma.	KMT2D TP53	7.36e-06	3	55	2	27749841
Pubmed	Distinct clinicopathological features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential.	NAB2 TP53	7.36e-06	3	55	2	25582503
Pubmed	Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA.	TERF2 TP53	7.36e-06	3	55	2	18056407
Pubmed	DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs.	TERF2 TP53	7.36e-06	3	55	2	28239143
Pubmed	Regulation of protein Citrullination through p53/PADI4 network in DNA damage response.	PADI4 TP53	7.36e-06	3	55	2	19843866
Pubmed	Radiogenomics in head and neck cancer: correlation of radiomic heterogeneity and somatic mutations in TP53, FAT1 and KMT2D.	KMT2D TP53	7.36e-06	3	55	2	31123786
Pubmed	SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction.	TERF2 TP53	7.36e-06	3	55	2	34232992
Pubmed	KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer.	KMT2D TP53	7.36e-06	3	55	2	32243837
Pubmed	Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.	TERF2 TP53	7.36e-06	3	55	2	21057505
Pubmed	Predictive Role of TP53, PIK3CA and MLL2 in ER+ HER2+ Breast Bancer: Biomarker Analysis of Neo-ALL-IN [NCT 01275859].	KMT2D TP53	7.36e-06	3	55	2	32988919
Pubmed	Cancer gene mutation frequencies for the U.S. population.	KMT2D TP53	1.47e-05	4	55	2	34645806
Pubmed	Control of stereocilia length during development of hair bundles.	CDH23 MYO15A	1.47e-05	4	55	2	37011103
Pubmed	Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites.	TERF2 TP53	1.47e-05	4	55	2	29126443
Pubmed	Different requirements of functional telomeres in neural stem cells and terminally differentiated neurons.	TERF2 TP53	1.47e-05	4	55	2	28428263
Pubmed	A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70.	ACIN1 TP53	1.47e-05	4	55	2	19058849
Pubmed	KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition.	KMT2D TP53	1.47e-05	4	55	2	36525973
Pubmed	A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation.	SASH1 TP53	1.47e-05	4	55	2	27885802
Pubmed	AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration.	AHNAK AHNAK2	1.47e-05	4	55	2	17185750
Pubmed	Role of 53BP1 oligomerization in regulating double-strand break repair.	TERF2 TP53	1.47e-05	4	55	2	23345425
Pubmed	TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer.	PADI4 TP53	1.47e-05	4	55	2	33941611
Pubmed	Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing.	CDH23 MYO15A	1.47e-05	4	55	2	35100259
Pubmed	Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal.	TERF2 TP53	1.47e-05	4	55	2	20339076
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	PRRC2C AHNAK BAG3 ARHGAP35 AHNAK2	2.38e-05	216	55	5	31519766
Pubmed	Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape.	CDH23 MYO15A	2.45e-05	5	55	2	20332152
Pubmed	An anterograde pathway for sensory axon degeneration gated by a cytoplasmic action of the transcriptional regulator P53.	CDH23 TP53	2.45e-05	5	55	2	33823136
Pubmed	KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer.	IRF2 TP53	2.45e-05	5	55	2	30905761
Pubmed	Targeting of the hair cell proteins cadherin 23, harmonin, myosin XVa, espin, and prestin in an epithelial cell model.	CDH23 MYO15A	2.45e-05	5	55	2	20505086
Pubmed	DNA-damage response and repair activities at uncapped telomeres depend on RNF8.	TERF2 TP53	2.45e-05	5	55	2	21857671
Pubmed	53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility.	TERF2 TP53	2.45e-05	5	55	2	18931659
Pubmed	Loss of function mutation of Eftud2, the gene responsible for mandibulofacial dysostosis with microcephaly (MFDM), leads to pre-implantation arrest in mouse.	TP53 EFTUD2	2.45e-05	5	55	2	31276534
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	KMT2D AHNAK TP53 FER1L6 EFTUD2	3.49e-05	234	55	5	36243803
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	HSPA12A KMT2D HYOU1 AHNAK BAG3 YLPM1 NUFIP2 NUDCD3 TERF2	3.65e-05	1049	55	9	27880917
Pubmed	DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.	TERF2 TP53	3.67e-05	6	55	2	15968270
Pubmed	p300-mediated acetylation of TRF2 is required for maintaining functional telomeres.	TERF2 TP53	3.67e-05	6	55	2	23307557
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	HYOU1 MLEC AHNAK PCLO ZFHX3 MYO15A AHNAK2 EFTUD2	3.77e-05	807	55	8	30575818
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RSBN1 TCF20 PRRC2C NUFIP2 ACIN1 WASHC2A	4.42e-05	407	55	6	12693553
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	PRRC2C YLPM1 NUFIP2 PDCD11 ACIN1 ZFHX3 EFTUD2	4.58e-05	605	55	7	28977666
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	KMT2D PRRC2C AHNAK ACIN1 TP53	4.88e-05	251	55	5	31076518
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	NELFE RSBN1 PRRC2C AHNAK YLPM1 NUFIP2 PDCD11 ACIN1 ISG20L2 TP53	5.09e-05	1371	55	10	36244648
Pubmed	Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse.	CDH23 MYO15A	5.13e-05	7	55	2	16962269
Pubmed	Removal of shelterin reveals the telomere end-protection problem.	TERF2 TP53	5.13e-05	7	55	2	22556254
Pubmed	Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients.	KMT2D TP53	5.13e-05	7	55	2	24323028
Pubmed	SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action.	AHNAK AHNAK2	5.13e-05	7	55	2	23415230
Pubmed	Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia.	CDH23 MYO15A	5.13e-05	7	55	2	21436032
Pubmed	[Studies on the genetics and pathology of the development of 8 labyrinth mutants (deaf-waltzer-shaker mutants) in the mouse (Mus musculus)].	CDH23 MYO15A	5.13e-05	7	55	2	13853422
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SH3PXD2B KMT2D AHNAK PDCD11 CARD10 ARHGAP35 WASHC2A ADAT1 AHNAK2	5.46e-05	1105	55	9	35748872
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	PRRC2C PCLO TCEAL2 FBF1 PARD3B TP53 EFTUD2	6.46e-05	639	55	7	23443559
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	PRRC2C YLPM1 NUFIP2 PDCD11 ACIN1 TP53 EFTUD2	6.59e-05	641	55	7	36057605
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	NELFE ZNHIT6 AHNAK NUFIP2 TP53 AHNAK2	7.15e-05	444	55	6	34795231
Pubmed	Human transcription factor protein interaction networks.	RSBN1 KMT2D TCF20 PRRC2C YLPM1 PDCD11 ISX ZFHX3 WASHC2A TP53	7.19e-05	1429	55	10	35140242
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	RSBN1 PRRC2C BAG3 YLPM1 NUFIP2 ACIN1 TP53	7.54e-05	655	55	7	35819319
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	HYOU1 PRRC2C AHNAK PCLO FBF1 YLPM1 ACIN1 ISG20L2 TERF2 FER1L6	7.75e-05	1442	55	10	35575683
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	NELFE TCF20 YLPM1 ACIN1 ZFHX3	8.59e-05	283	55	5	30585729
Pubmed	Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.	PRRC2C AHNAK NUFIP2	8.77e-05	54	55	3	25631074
Pubmed	Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.	CDH23 MYO15A	8.78e-05	9	55	2	19339464
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	KMT2D PRRC2C AHNAK ACIN1 PARD3B TERF2	9.65e-05	469	55	6	27634302
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	RSBN1 SH3PXD2B TCF20 ISG20L2 ARHGAP35 WASHC2A	1.00e-04	472	55	6	38943005
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	HYOU1 AHNAK BAG3 NUFIP2 ACIN1 EFTUD2	1.06e-04	477	55	6	31300519
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	PRRC2C AHNAK BAG3 NUFIP2 AHNAK2	1.09e-04	298	55	5	30737378
Pubmed	CCND2, CTNNB1, DDX3X, GLI2, SMARCA4, MYC, MYCN, PTCH1, TP53, and MLL2 gene variants and risk of childhood medulloblastoma.	KMT2D TP53	1.10e-04	10	55	2	26290144
Pubmed	Mutation in Eftud2 causes craniofacial defects in mice via mis-splicing of Mdm2 and increased P53.	TP53 EFTUD2	1.10e-04	10	55	2	33601405
Pubmed	BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.	PRRC2C AHNAK BAG3 EFTUD2	1.11e-04	156	55	4	32850835
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	SH3PXD2B PRRC2C PDCD11 TERF2 TP53 EFTUD2	1.17e-04	486	55	6	30940648
Interaction	NUP43 interactions	FSIP2 RSBN1 KMT2D TCF20 PRRC2C PDCD11 ACIN1 ZFHX3 TERF2 TP53 AHNAK2	8.09e-07	625	55	11	int:NUP43
Interaction	CHD4 interactions	NELFE TCF20 PRRC2C AHNAK NAB2 YLPM1 NUFIP2 PDCD11 ACIN1 ZFHX3 TP53 EFTUD2	6.63e-06	938	55	12	int:CHD4
Interaction	NAA40 interactions	NELFE PRRC2C AHNAK BAG3 YLPM1 NUFIP2 ACIN1 NUDCD3 ARHGAP35 TP53 AHNAK2 EFTUD2	1.01e-05	978	55	12	int:NAA40
Interaction	SMC5 interactions	NELFE RSBN1 TCF20 PRRC2C AHNAK YLPM1 NUFIP2 PDCD11 ACIN1 TERF2 TP53 EFTUD2	1.27e-05	1000	55	12	int:SMC5
Interaction	SUPT5H interactions	NELFE KMT2D TCF20 ACIN1 WASHC2A TERF2 TP53 EFTUD2	1.40e-05	408	55	8	int:SUPT5H
Interaction	DIS3 interactions	NELFE SH3PXD2B AHNAK CHORDC1 TP53 EFTUD2	1.44e-05	194	55	6	int:DIS3
Interaction	ANXA2 interactions	NELFE MICALL2 AHNAK SYTL2 BAG3 TP53 AHNAK2 EFTUD2	1.69e-05	419	55	8	int:ANXA2
Interaction	WWTR1 interactions	SH3PXD2B KMT2D TCF20 PRRC2C BAG3 PDCD11 CHORDC1 TP53	1.78e-05	422	55	8	int:WWTR1
Interaction	KBTBD4 interactions	SH3PXD2B AHNAK BAG3 NUFIP2 NUDCD3 CHORDC1 WASHC2A	2.32e-05	316	55	7	int:KBTBD4
Interaction	YAP1 interactions	NELFE KMT2D HYOU1 TCF20 PRRC2C AHNAK BAG3 YLPM1 NUFIP2 ACIN1 ARHGAP35 TP53	3.12e-05	1095	55	12	int:YAP1
Interaction	XRCC6 interactions	NELFE HYOU1 TCF20 YLPM1 ACIN1 IRF2 ZFHX3 CHORDC1 TERF2 TP53 EFTUD2	3.46e-05	928	55	11	int:XRCC6
Interaction	SUB1 interactions	NELFE ACIN1 CHORDC1 TERF2 TP53 EFTUD2	5.59e-05	247	55	6	int:SUB1
Interaction	PSPC1 interactions	RSBN1 PRRC2C YLPM1 NUFIP2 ISG20L2 ARHGAP35 TP53 EFTUD2	7.30e-05	515	55	8	int:PSPC1
Interaction	NPM1 interactions	NELFE RSBN1 PADI4 MICALL2 PRRC2C NUFIP2 CCDC190 PDCD11 ISG20L2 TP53 AHNAK2 EFTUD2	7.64e-05	1201	55	12	int:NPM1
Interaction	CEBPB interactions	NELFE KMT2D HYOU1 TCF20 PRRC2C AHNAK YLPM1 NUFIP2 ACIN1 IRF2 CHORDC1 TERF2 EFTUD2	1.05e-04	1443	55	13	int:CEBPB
Interaction	ZNF24 interactions	ZSCAN20 PRRC2C YLPM1 PGBD1 TP53	1.11e-04	174	55	5	int:ZNF24
Interaction	TOP3B interactions	SH3PXD2B KMT2D HYOU1 AHNAK NUFIP2 PDCD11 ACIN1 CARD10 ARHGAP35 WASHC2A ADAT1 TP53 AHNAK2	1.26e-04	1470	55	13	int:TOP3B
Interaction	FKBP5 interactions	PRRC2C BAG3 PDCD11 NUDCD3 CHORDC1 TP53 EFTUD2	1.27e-04	414	55	7	int:FKBP5
Interaction	DDX21 interactions	NELFE RSBN1 PRRC2C YLPM1 PDCD11 ACIN1 TERF2 TP53 EFTUD2	1.29e-04	718	55	9	int:DDX21
Interaction	PLOD3 interactions	MLEC AHNAK NAB2 TP53 EFTUD2	1.41e-04	183	55	5	int:PLOD3
Interaction	SENP3 interactions	RSBN1 KMT2D NAB2 PDCD11 ACIN1 TP53	1.66e-04	301	55	6	int:SENP3
Interaction	SIRT7 interactions	HYOU1 TCF20 PRRC2C AHNAK YLPM1 NUFIP2 PDCD11 ACIN1 TP53	1.68e-04	744	55	9	int:SIRT7
Interaction	USP7 interactions	RSBN1 PADI4 KMT2D TCF20 AHNAK TCEAL2 FBF1 YLPM1 IRF2 TP53 FER1L6 EFTUD2	1.78e-04	1313	55	12	int:USP7
Interaction	KDM1A interactions	KMT2D ZNHIT6 TCF20 AHNAK BAG3 ZFHX3 CARD10 NUDCD3 TP53 EFTUD2	2.03e-04	941	55	10	int:KDM1A
Interaction	MACROD2 interactions	HSPA12A TERF2	2.03e-04	8	55	2	int:MACROD2
Interaction	PEF1 interactions	BAG3 NUDCD3 TP53 EFTUD2	2.16e-04	108	55	4	int:PEF1
Interaction	DPY30 interactions	HSPA12A KMT2D IRF2 CHORDC1 EFTUD2	2.33e-04	204	55	5	int:DPY30
Cytoband	1q23.3	CFAP126 PRRC2C CCDC190	2.88e-05	49	55	3	1q23.3
Cytoband	1p36.13	PADI4 SRARP	2.08e-03	56	55	2	1p36.13
Cytoband	Ensembl 112 genes in cytogenetic band chr1q23	CFAP126 CCDC190 ISG20L2	2.56e-03	226	55	3	chr1q23
GeneFamily	PDZ domain containing	AHNAK PCLO PARD3B AHNAK2	2.29e-04	152	36	4	1220
GeneFamily	Heat shock 70kDa proteins	HSPA12A HYOU1	5.14e-04	17	36	2	583
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	ZSCAN20 TERF2	4.98e-03	53	36	2	532
Coexpression	LAU_APOPTOSIS_CDKN2A_UP	PDCD11 ACIN1 CARD10 TP53	5.46e-06	55	55	4	M1411
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Epi-like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DHDH SASH1 FBF1 PARD3B MYO15A	8.94e-07	142	55	5	a05b320cf182b2aaf18df7c40045dc65b659bf20
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Epi-like-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DHDH SASH1 FBF1 PARD3B MYO15A	8.94e-07	142	55	5	d52da766e031f7409eb5a7a9fa88f48e14a79d8b
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PRRC2C AHNAK PCLO NUFIP2 ZFHX3	3.37e-06	186	55	5	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AHNAK SYTL2 CCDC190 FER1L6 AHNAK2	4.45e-06	197	55	5	5c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PRRC2C AHNAK SYTL2 YLPM1 ADAT1	4.79e-06	200	55	5	cc8368665bc6bb7c4f39632ccff07ceaa98a7b65
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid-Megakaryocyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PRRC2C AHNAK SYTL2 YLPM1 ADAT1	4.79e-06	200	55	5	0d76b006d8e8b32174e65e400acd0674354b962c
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial-Astrocyte\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	ZSCAN20 AHNAK CDH23 IRF2	2.86e-05	142	55	4	85e573616e54d41391b4ad8c3d38e4ca92112673
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MICALL2 PDGFRL CMYA5 EFTUD2	3.11e-05	145	55	4	e808502fa52baf1c400f3c9b918a167127e78af9
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SH3PXD2B AHNAK BAG3 PARD3B	6.04e-05	172	55	4	55fba5ce0ead1114e1a76f67ad68432c6bac90e5
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRRC2C AHNAK NUFIP2 CMYA5	6.60e-05	176	55	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	droplet-Liver-LIVER_HEP\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPA12A PRRC2C AHNAK PARD3B	7.21e-05	180	55	4	423454e3390080ae03bb3cbb267255ebfe4df080
ToppCell	droplet-Liver-LIVER_HEP-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPA12A PRRC2C AHNAK PARD3B	7.21e-05	180	55	4	dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYTL2 CCDC190 FER1L6 CFAP65	8.88e-05	190	55	4	2fdc024d3d673a0134b74b4c5a63afe924995730
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CFAP126 CARD10 FER1L6 AHNAK2	1.00e-04	196	55	4	1efacc37bbfbd05b5d4db3dd10f6d9a238d23e31
ToppCell	5'-Adult-LargeIntestine-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FSIP2 SYTL2 FER1L6 CFAP65	1.00e-04	196	55	4	847b3377f463bfded046eec63cc1b547f3dc33c1
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CFAP126 CARD10 FER1L6 AHNAK2	1.00e-04	196	55	4	3e99a367b7d817e1f1221450fcec20ad7a7c7a2a
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CFAP126 CARD10 FER1L6 AHNAK2	1.02e-04	197	55	4	08b371309cd790b171ed76cabc7d910e71cd2835
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CFAP126 CARD10 FER1L6 AHNAK2	1.02e-04	197	55	4	9f49feee38647bbf964974aac96fa75602186b5c
ToppCell	3'-Adult-Distal_Rectal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MICALL2 PRRC2C SYTL2 BAG3	1.04e-04	198	55	4	7ad7726fc405806b1d7824f58548073ea5e0c70b
ToppCell	3'-Adult-Distal_Rectal-Epithelial-epithelial_progenitor_cell-TA\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MICALL2 PRRC2C SYTL2 BAG3	1.04e-04	198	55	4	1fbec311f2c987ca90a023a5989128c05aa12d5c
ToppCell	3'-Adult-Distal_Rectal-Epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MICALL2 PRRC2C SYTL2 BAG3	1.04e-04	198	55	4	ceede961ad9af6a3159db7efaa5087bf38aafc2d
ToppCell	3'-Adult-Distal_Rectal-Epithelial-epithelial_progenitor_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MICALL2 PRRC2C SYTL2 BAG3	1.04e-04	198	55	4	4f26a60e99f42343e5af7221723e108a1a1b7827
ToppCell	(1)_Osterolineage_cells-(11)_OLC-2\|(1)_Osterolineage_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	ZNHIT6 PDGFRL AHNAK AHNAK2	1.04e-04	198	55	4	9f9dcf23ffb333105263132d87b90095642294cf
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PRRC2C AHNAK NUFIP2 ACIN1	1.08e-04	200	55	4	12f1685ce8f218433068e090c9d839cd5a1910bf
Disease	hypertrophic cardiomyopathy	AHNAK SRARP BAG3 PARD3B	2.31e-05	92	53	4	EFO_0000538
Disease	HEPATOCELLULAR CARCINOMA	PDGFRL TP53	1.13e-04	9	53	2	114550
Disease	Adult Hepatocellular Carcinoma	PDGFRL TP53	1.13e-04	9	53	2	C0279607
Disease	Hepatocellular carcinoma	PDGFRL TP53	1.13e-04	9	53	2	cv:C2239176
Disease	glioblastoma (implicated_via_orthology)	BAG3 TP53	1.13e-04	9	53	2	DOID:3068 (implicated_via_orthology)
Disease	gastric adenocarcinoma (is_implicated_in)	KMT2D TP53	1.72e-04	11	53	2	DOID:3717 (is_implicated_in)
Disease	hepatocellular carcinoma (is_implicated_in)	PDGFRL ZFHX3 TP53 EFTUD2	3.17e-04	181	53	4	DOID:684 (is_implicated_in)
Disease	heart failure	HSPA12A SRARP BAG3 ZFHX3	3.45e-04	185	53	4	EFO_0003144
Disease	T-Cell Lymphoma	KMT2D TP53	3.74e-04	16	53	2	C0079772
Disease	sphingomyelin 14:0 measurement	ZFHX3 CHORDC1	4.23e-04	17	53	2	EFO_0010390
Disease	information processing speed	SASH1 CDH23 ZFHX3	4.87e-04	85	53	3	EFO_0004363
Disease	cytomegalovirus virus reactivation, response to allogeneic hematopoietic stem cell transplant	PCLO CDH23	5.31e-04	19	53	2	EFO_0007044, EFO_0020106
Disease	hearing impairment	SH3PXD2B CDH23 MYO15A	7.38e-04	98	53	3	C1384666
Disease	Colorectal cancer	PDGFRL TP53	1.08e-03	27	53	2	cv:C0346629
Disease	COLORECTAL CANCER	PDGFRL TP53	1.08e-03	27	53	2	114500
Disease	Neoplasm of the large intestine	PDGFRL TP53	1.08e-03	27	53	2	cv:C0009404
Disease	Sezary Syndrome	KMT2D TP53	1.08e-03	27	53	2	C0036920
Disease	suicidal ideation	CDH23 ZFHX3	1.25e-03	29	53	2	EFO_0004320

Protein segments in the cluster

Peptide	Gene	Start	Entry
PPPAEHEVKKVTLGD	ACIN1	961	Q9UKV3
GPPPGAEEKEKEKEK	CARD10	256	Q9BWT7
PDVDLHLKGPKVKGD	AHNAK	1656	Q09666
DIDIHGPEGKLKGPK	AHNAK	4566	Q09666
QEHPPGKQEKTEKHP	CFAP92	251	Q9ULG3
KPPVELKGPDGIHVV	CDH23	3271	Q9H251
GIRLPKKGKPEPNHE	ADAT1	16	Q9BUB4
GLEKPPKDQPQEGRK	ISX	66	Q2M1V0
HTGKHQPGVDKPDPK	IRF2	61	P14316
PGVVVDIAHGPPAKK	PADI4	46	Q9UM07
DGVLKTKVPPPVHGK	PARD3B	311	Q8TEW8
TLEGKLKDPEKGPVP	NELFE	91	P18615
GHQEVEKVQPPGPVK	NUDCD3	126	Q8IVD9
LKPNHKKEPGLFEPD	MYO15A	1796	Q9UKN7
HPEELGGPPLKKLKQ	NAB2	366	Q15742
DDVPKLQPHPGLEKK	MLEC	216	Q14165
GKGKQPKEDRPEHYP	CFAP65	1741	Q6ZU64
LKPDGNTGKQIPPKH	CCDC190	216	Q86UF4
ESPIKIVPHVGKKPV	FSIP2	6516	Q5CZC0
EEEKKPHLQGKPGRP	MICALL2	696	Q8IY33
VQKEQGKPEGIIKPP	PCLO	196	Q9Y6V0
HGKEEIKVIPTPPAD	PDE6C	326	P51160
GEPPPKKALEGNAKH	ISG20L2	11	Q9H9L3
VEGKHPPEKLLVKDG	HSPA12A	546	O43301
KKGEPHHELPPGSTK	TP53	291	P04637
KAAKDPGKGELPNHP	FBF1	101	Q8TES7
GVAPAPEGEKKQKPA	HYOU1	676	Q9Y4L1
EPEKKDKPHQPLELP	CMYA5	1621	Q8N3K9
DTKVKEEPPINHPVG	ZNHIT6	196	Q9NWK9
PEILGKPHDPDSQKK	CFAP126	111	Q5VTH2
VKGEHKEFPLPPVPK	DHDH	261	Q9UQ10
GEAEAPPKHPGVLKV	BAG3	411	O95817
HTPVAQEPPKDGKPK	FER1L6	1171	Q2WGJ9
EEPDKEGKEKPHAGV	RSBN1	66	Q5VWQ0
EPVPGKKLPTTGEVH	SYTL2	781	Q9HCH5
EVPEAKGKPVKAAPV	SRARP	131	Q8NEQ6
PVENKEHKPGPIGKE	PRRC2C	2106	Q9Y520
PGPAPENEDGLVKVK	PGBD1	6	Q96JS3
GQHLPKNKRPKEPGE	PDGFRL	21	Q15198
VKPKPPVHFEITKGD	ARHGAP35	1041	Q9NRY4
VPEGAGPKVHLPKVE	AHNAK2	906	Q8IVF2
KGRHNSEKPPEPVKP	CHORDC1	61	Q9UHD1
PEPKKEPAGHSQKKG	PDCD11	616	Q14690
GPGKHAEKELCKDPP	ZSCAN20	231	P17040
GAEGSPKAQPKPLKH	NUFIP2	61	Q7Z417
PEDLNPPKEEHIGKK	SH3PXD2B	126	A1X283
QPDPEHLDKPKLKAG	SASH1	491	O94885
GKIDNEEQPPHEGKP	TCEAL2	16	Q9H3H9
IPEGSADGEPKPKKQ	TCF20	1566	Q9UGU0
HKKGPVVAKDTPEPV	YLPM1	316	P49750
QKEVGKGRDPDAHPK	WASHC2A	821	Q641Q2
DPGLKKHQEEPEKPS	ZBTB32	121	Q9Y2Y4
QHIPSPKVGAKPKIE	EFTUD2	436	Q15029
GKEDKQPAPGPVEKP	TERF2	296	Q15554
AHKGKGEPLPVPKKE	ZFHX3	3246	Q15911
KLKEPQPQDHKPGLG	UNQ9165/PRO28630	121	Q6UXU0
PEVKPKVEEGGRHPS	KMT2D	3116	O14686