Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	coumarin 7-hydroxylase activity	CYP2A6 CYP2A7 CYP2A13	1.07e-08	3	45	3	GO:0008389
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	CYP2A6 CYP2A7 CYP2A13 FMO2 FMO3 TET1	4.63e-06	194	45	6	GO:0016705
GeneOntologyMolecularFunction	monooxygenase activity	CYP2A6 CYP2A7 CYP2A13 FMO2 FMO3	5.90e-06	115	45	5	GO:0004497
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP2A6 CYP2A7 CYP2A13	2.09e-05	24	45	3	GO:0008392
GeneOntologyMolecularFunction	triplex DNA binding	DDX11L8 DDX11	2.97e-05	4	45	2	GO:0045142
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2A6 CYP2A7 CYP2A13	3.01e-05	27	45	3	GO:0008391
GeneOntologyMolecularFunction	hypotaurine monooxygenase activity	FMO2 FMO3	4.94e-05	5	45	2	GO:0047822
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP2A6 CYP2A7 CYP2A13	6.09e-05	34	45	3	GO:0008395
GeneOntologyMolecularFunction	aromatase activity	CYP2A6 CYP2A7 CYP2A13	6.66e-05	35	45	3	GO:0070330
GeneOntologyMolecularFunction	N,N-dimethylaniline monooxygenase activity	FMO2 FMO3	7.41e-05	6	45	2	GO:0004499
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2A6 CYP2A7 CYP2A13	1.83e-04	49	45	3	GO:0016712
GeneOntologyMolecularFunction	5'-3' DNA helicase activity	DDX11L8 DDX11	2.70e-04	11	45	2	GO:0043139
GeneOntologyMolecularFunction	heme binding	DUOX2 CYP2A6 CYP2A7 CYP2A13	3.96e-04	154	45	4	GO:0020037
GeneOntologyMolecularFunction	G-quadruplex DNA binding	DDX11L8 DDX11	4.44e-04	14	45	2	GO:0051880
GeneOntologyMolecularFunction	tetrapyrrole binding	DUOX2 CYP2A6 CYP2A7 CYP2A13	5.03e-04	164	45	4	GO:0046906
GeneOntologyMolecularFunction	iron ion binding	CYP2A6 CYP2A7 CYP2A13 TET1	5.26e-04	166	45	4	GO:0005506
GeneOntologyMolecularFunction	DNA replication origin binding	DDX11L8 DDX11	7.43e-04	18	45	2	GO:0003688
GeneOntologyMolecularFunction	transition metal ion binding	ADCY10 ZCCHC14 CYP2A6 CYP2A7 CYP2A13 MARCHF10 ZFHX4 SIRT3 TET1	1.16e-03	1189	45	9	GO:0046914
GeneOntologyMolecularFunction	oxidoreductase activity	DUOX2 CYP2A6 CYP2A7 CYP2A13 FMO2 FMO3 TET1	1.51e-03	766	45	7	GO:0016491
GeneOntologyMolecularFunction	single-stranded RNA binding	ADARB2 DDX11L8 DDX11	2.00e-03	111	45	3	GO:0003727
GeneOntologyMolecularFunction	beta-catenin binding	DCHS1 CDH5 CDH9	2.50e-03	120	45	3	GO:0008013
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	FMO2 FMO3	3.67e-03	40	45	2	GO:0016709
GeneOntologyMolecularFunction	4 iron, 4 sulfur cluster binding	DDX11L8 DDX11	5.03e-03	47	45	2	GO:0051539
GeneOntologyMolecularFunction	calcium ion binding	DCHS1 DUOX2 PCDHGC4 CDH5 CDH9 SYT6	6.39e-03	749	45	6	GO:0005509
GeneOntologyBiologicalProcess	phenylpropanoid metabolic process	CYP2A6 CYP2A7 CYP2A13	1.15e-06	10	45	3	GO:0009698
GeneOntologyBiologicalProcess	coumarin metabolic process	CYP2A6 CYP2A7 CYP2A13	1.15e-06	10	45	3	GO:0009804
GeneOntologyBiologicalProcess	cellular response to xenobiotic stimulus	CYP2A6 CYP2A7 CYP2A13 FMO2 FMO3 CRKL	8.34e-06	222	45	6	GO:0071466
GeneOntologyBiologicalProcess	xenobiotic metabolic process	CYP2A6 CYP2A7 CYP2A13 FMO2 FMO3	1.36e-05	141	45	5	GO:0006805
GeneOntologyBiologicalProcess	secondary metabolic process	CYP2A6 CYP2A7 CYP2A13 FMO2	1.37e-05	67	45	4	GO:0019748
GeneOntologyBiologicalProcess	epoxygenase P450 pathway	CYP2A6 CYP2A7 CYP2A13	1.45e-05	22	45	3	GO:0019373
GeneOntologyBiologicalProcess	response to xenobiotic stimulus	CYP2A6 CYP2A7 CYP2A13 FMO2 FMO3 GNAS CRKL	1.30e-04	525	45	7	GO:0009410
GeneOntologyBiologicalProcess	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	DCHS1 CDH5 CDH9	2.11e-04	53	45	3	GO:0016339
GeneOntologyBiologicalProcess	establishment of sister chromatid cohesion	DDX11L8 DDX11	2.53e-04	11	45	2	GO:0034085
GeneOntologyBiologicalProcess	sphingomyelin biosynthetic process	SGMS1 ABCA8	2.53e-04	11	45	2	GO:0006686
GeneOntologyCellularComponent	extrinsic component of plasma membrane	DCHS1 GNAS CDH5 CDH9 CRKL	1.11e-05	137	45	5	GO:0019897
GeneOntologyCellularComponent	catenin complex	DCHS1 CDH5 CDH9	4.43e-05	32	45	3	GO:0016342
GeneOntologyCellularComponent	extrinsic component of membrane	DCHS1 GNAS CDH5 CDH9 CRKL	1.32e-04	230	45	5	GO:0019898
GeneOntologyCellularComponent	Ctf18 RFC-like complex	DDX11L8 DDX11	2.02e-04	10	45	2	GO:0031390
MousePheno	decreased intestinal cholesterol absorption	CYP2A6 CYP2A7 CYP2A13	8.73e-06	17	34	3	MP:0002647
MousePheno	abnormal intestinal cholesterol absorption	CYP2A6 CYP2A7 CYP2A13	1.24e-05	19	34	3	MP:0002645
MousePheno	abnormal intestinal lipid absorption	CYP2A6 CYP2A7 CYP2A13	5.64e-05	31	34	3	MP:0005342
MousePheno	failure of heart looping	DDX11L8 SMAD5 DDX11	1.52e-04	43	34	3	MP:0004251
MousePheno	increased allantois apoptosis	DDX11L8 DDX11	1.59e-04	8	34	2	MP:0003891
MousePheno	abnormal bile salt homeostasis	CYP2A6 CYP2A7 CYP2A13	1.98e-04	47	34	3	MP:0005365
MousePheno	absent paraxial mesoderm	DDX11L8 DDX11	2.05e-04	9	34	2	MP:0012184
MousePheno	abnormal neural tube closure	AMBRA1 DDX11L8 CRKL TET1 SMAD5 DDX11	2.66e-04	378	34	6	MP:0003720
MousePheno	decreased paraxial mesoderm size	DDX11L8 DDX11	3.73e-04	12	34	2	MP:0012183
MousePheno	abnormal intestinal absorption	CYP2A6 CYP2A7 CYP2A13	3.89e-04	59	34	3	MP:0001666
Domain	Cyt_P450_E_grp-I_CYP2A-like	CYP2A6 CYP2A7 CYP2A13	4.87e-08	4	44	3	IPR008067
Domain	Arp3_met	ACTR3B ACTR3	1.62e-05	3	44	2	IPR015623
Domain	FMO-like	FMO2 FMO3	5.40e-05	5	44	2	PF00743
Domain	Flavin_mOase-like	FMO2 FMO3	5.40e-05	5	44	2	IPR020946
Domain	Flavin_mOase	FMO2 FMO3	5.40e-05	5	44	2	IPR000960
Domain	DiMe-aniline_mOase	FMO2 FMO3	5.40e-05	5	44	2	IPR012143
Domain	Cadherin_CS	DCHS1 PCDHGC4 CDH5 CDH9	1.24e-04	109	44	4	IPR020894
Domain	Cadherin	DCHS1 PCDHGC4 CDH5 CDH9	1.43e-04	113	44	4	PF00028
Domain	CADHERIN_1	DCHS1 PCDHGC4 CDH5 CDH9	1.43e-04	113	44	4	PS00232
Domain	CADHERIN_2	DCHS1 PCDHGC4 CDH5 CDH9	1.48e-04	114	44	4	PS50268
Domain	-	DCHS1 PCDHGC4 CDH5 CDH9	1.48e-04	114	44	4	2.60.40.60
Domain	CA	DCHS1 PCDHGC4 CDH5 CDH9	1.53e-04	115	44	4	SM00112
Domain	Cadherin-like	DCHS1 PCDHGC4 CDH5 CDH9	1.58e-04	116	44	4	IPR015919
Domain	Cyt_P450_E_grp-I	CYP2A6 CYP2A7 CYP2A13	1.62e-04	45	44	3	IPR002401
Domain	Cadherin	DCHS1 PCDHGC4 CDH5 CDH9	1.69e-04	118	44	4	IPR002126
Domain	Cyt_P450_CS	CYP2A6 CYP2A7 CYP2A13	2.63e-04	53	44	3	IPR017972
Domain	CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2A13	3.27e-04	57	44	3	PS00086
Domain	-	CYP2A6 CYP2A7 CYP2A13	3.44e-04	58	44	3	1.10.630.10
Domain	p450	CYP2A6 CYP2A7 CYP2A13	3.44e-04	58	44	3	PF00067
Domain	Cyt_P450	CYP2A6 CYP2A7 CYP2A13	3.80e-04	60	44	3	IPR001128
Domain	Actin/actin-like_CS	ACTR3B ACTR3	8.10e-04	18	44	2	IPR020902
Domain	ACTINS_ACT_LIKE	ACTR3B ACTR3	9.04e-04	19	44	2	PS01132
Domain	Cadherin_C	CDH5 CDH9	1.57e-03	25	44	2	PF01049
Domain	Cadherin_cytoplasmic-dom	CDH5 CDH9	1.57e-03	25	44	2	IPR000233
Domain	Catenin_binding_dom	CDH5 CDH9	2.11e-03	29	44	2	IPR027397
Domain	-	CDH5 CDH9	2.11e-03	29	44	2	4.10.900.10
Domain	Actin	ACTR3B ACTR3	2.42e-03	31	44	2	IPR004000
Domain	Actin	ACTR3B ACTR3	2.42e-03	31	44	2	PF00022
Domain	ACTIN	ACTR3B ACTR3	2.42e-03	31	44	2	SM00268
Domain	-	FMO2 FMO3	7.71e-03	56	44	2	3.50.50.60
Domain	FAD/NAD-binding_dom	FMO2 FMO3	7.97e-03	57	44	2	IPR023753
Domain	SAM_1	ZCCHC14 SGMS1	1.12e-02	68	44	2	PF00536
Pathway	KEGG_DRUG_METABOLISM_CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2A13 FMO2 FMO3	5.46e-07	72	32	5	M9257
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2A6 CYP2A7 CYP2A13	1.73e-06	11	32	3	M27130
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2A6 CYP2A7 CYP2A13	2.31e-06	12	32	3	MM14847
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	CYP2A6 CYP2A7 CYP2A13 FMO2 FMO3	3.41e-06	104	32	5	M738
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	CYP2A6 CYP2A7 CYP2A13 FMO2 FMO3	3.57e-06	105	32	5	MM14842
Pathway	REACTOME_FATTY_ACIDS	CYP2A6 CYP2A7 CYP2A13	8.47e-06	18	32	3	MM14841
Pathway	REACTOME_XENOBIOTICS	CYP2A6 CYP2A7 CYP2A13	1.82e-05	23	32	3	M5372
Pathway	REACTOME_XENOBIOTICS	CYP2A6 CYP2A7 CYP2A13	2.36e-05	25	32	3	MM14846
Pathway	WP_CATALYTIC_CYCLE_OF_MAMMALIAN_FLAVINCONTAINING_MONOOXYGENASES_FMOS	FMO2 FMO3	4.97e-05	5	32	2	M39449
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_TO_DNA_ADDUCTS	CYP2A6 CYP2A13	4.97e-05	5	32	2	M47808
Pathway	WP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II	CYP2A6 CYP2A7 CYP2A13 FMO2 FMO3	5.29e-05	183	32	5	M39588
Pathway	WP_NICOTINE_METABOLISM_IN_LIVER_CELLS	CYP2A6 FMO3	7.45e-05	6	32	2	M39600
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	CYP2A6 CYP2A7 CYP2A13 FMO2 FMO3	1.24e-04	219	32	5	MM14838
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	CYP2A6 CYP2A7 CYP2A13 FMO2 FMO3	1.26e-04	220	32	5	M10320
Pathway	KEGG_DRUG_METABOLISM_OTHER_ENZYMES	CYP2A6 CYP2A7 CYP2A13	2.05e-04	51	32	3	M17726
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2A13	3.67e-04	62	32	3	M39653
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP2A6 CYP2A7 CYP2A13	4.03e-04	64	32	3	M5650
Pathway	KEGG_RETINOL_METABOLISM	CYP2A6 CYP2A7 CYP2A13	4.03e-04	64	32	3	M9488
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP2A6 CYP2A7 CYP2A13	4.41e-04	66	32	3	MM14839
Pathway	REACTOME_FATTY_ACIDS	CYP2A7 CYP2A13	5.15e-04	15	32	2	M27126
Pathway	WP_TAMOXIFEN_METABOLISM	CYP2A6 FMO3	1.02e-03	21	32	2	M39631
Pathway	WP_HIPPO_SIGNALING_REGULATION	GNAS CDH5 CDH9	1.40e-03	98	32	3	M39830
Pathway	REACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION	CYP2A6 CYP2A13	1.57e-03	26	32	2	MM15190
Pathway	WP_THERMOGENESIS	ADCY10 GNAS MAPK13	1.85e-03	108	32	3	M39746
Pubmed	Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.	CYP2A6 CYP2A7 CYP2A13	2.02e-09	3	45	3	1417950
Pubmed	Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.	CYP2A6 CYP2A7 CYP2A13	2.02e-09	3	45	3	31645370
Pubmed	Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.	CYP2A6 CYP2A7 CYP2A13	2.02e-09	3	45	3	24045421
Pubmed	Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.	CYP2A6 CYP2A7 CYP2A13	2.02e-09	3	45	3	32987105
Pubmed	Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.	CYP2A6 CYP2A7 CYP2A13	2.02e-09	3	45	3	3346244
Pubmed	Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.	CYP2A6 CYP2A7 CYP2A13	2.02e-09	3	45	3	22217847
Pubmed	Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.	CYP2A6 CYP2A7 CYP2A13	2.02e-09	3	45	3	2765478
Pubmed	Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.	CYP2A6 CYP2A7 CYP2A13	2.02e-09	3	45	3	2415518
Pubmed	Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.	CYP2A6 CYP2A7 CYP2A13	2.02e-09	3	45	3	2733794
Pubmed	A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.	CYP2A6 CYP2A7 CYP2A13	2.02e-09	3	45	3	8297477
Pubmed	Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.	CYP2A6 CYP2A7 CYP2A13	2.02e-09	3	45	3	22890016
Pubmed	Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.	CYP2A6 CYP2A7 CYP2A13	2.02e-09	3	45	3	8188299
Pubmed	Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.	CYP2A6 CYP2A7 CYP2A13	2.02e-09	3	45	3	8484736
Pubmed	Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.	CYP2A6 CYP2A7 CYP2A13	2.02e-09	3	45	3	8250953
Pubmed	The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.	CYP2A6 CYP2A7 CYP2A13	2.02e-09	3	45	3	2703500
Pubmed	Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.	CYP2A6 CYP2A7 CYP2A13	8.09e-09	4	45	3	9408084
Pubmed	A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.	CYP2A6 CYP2A7 CYP2A13	8.09e-09	4	45	3	7565685
Pubmed	Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.	CYP2A6 CYP2A7 CYP2A13	8.09e-09	4	45	3	10490589
Pubmed	Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.	CYP2A6 CYP2A7 CYP2A13	8.09e-09	4	45	3	1970547
Pubmed	A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.	CYP2A6 CYP2A7 CYP2A13	4.04e-08	6	45	3	7668294
Pubmed	Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.	CYP2A6 CYP2A7 CYP2A13	4.04e-08	6	45	3	8587134
Pubmed	Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.	CYP2A6 CYP2A7 CYP2A13	7.06e-08	7	45	3	9630227
Pubmed	Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.	CYP2A6 CYP2A7 CYP2A13	7.06e-08	7	45	3	14630516
Pubmed	Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.	CYP2A6 CYP2A7 CYP2A13	1.69e-07	9	45	3	37838304
Pubmed	Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.	CYP2A6 CYP2A7 CYP2A13	9.11e-07	15	45	3	29968852
Pubmed	Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.	CYP2A6 CYP2A7 CYP2A13	1.36e-06	17	45	3	27197076
Pubmed	Expression of CYP2A genes in human liver and extrahepatic tissues.	CYP2A7 CYP2A13	1.64e-06	2	45	2	10353262
Pubmed	Expression and alternative splicing of the cytochrome P-450 CYP2A7.	CYP2A6 CYP2A7	1.64e-06	2	45	2	7864805
Pubmed	Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.	CYP2A6 CYP2A13	1.64e-06	2	45	2	28298240
Pubmed	Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.	CYP2A6 CYP2A13	1.64e-06	2	45	2	6309775
Pubmed	Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.	CYP2A6 CYP2A7	1.64e-06	2	45	2	12325023
Pubmed	Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.	CYP2A6 CYP2A13	1.64e-06	2	45	2	21418183
Pubmed	Different Effects of Polymorphic Flavin-Containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-Related Disease in a General Population in Japan.	CYP2A6 FMO3	1.64e-06	2	45	2	33038907
Pubmed	Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.	CYP2A6 CYP2A13	1.64e-06	2	45	2	22696418
Pubmed	Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.	CYP2A6 CYP2A13	1.64e-06	2	45	2	22262919
Pubmed	Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.	CYP2A6 CYP2A13	1.64e-06	2	45	2	30876690
Pubmed	CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.	CYP2A6 CYP2A13	1.64e-06	2	45	2	21395539
Pubmed	Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.	CYP2A6 CYP2A13	1.64e-06	2	45	2	25635819
Pubmed	Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.	CYP2A6 CYP2A13	1.64e-06	2	45	2	12162851
Pubmed	Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.	CYP2A6 CYP2A13	1.64e-06	2	45	2	1302041
Pubmed	Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.	CYP2A6 CYP2A13	1.64e-06	2	45	2	8395817
Pubmed	Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.	CYP2A6 CYP2A13	1.64e-06	2	45	2	25804444
Pubmed	Genetic variation between mice in their metabolism of coumarin and its derivatives.	CYP2A6 CYP2A13	1.64e-06	2	45	2	566237
Pubmed	Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.	CYP2A6 CYP2A13	1.64e-06	2	45	2	1520280
Pubmed	Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.	CYP2A6 CYP2A13	1.64e-06	2	45	2	19923441
Pubmed	Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.	CYP2A6 CYP2A13	1.64e-06	2	45	2	23917075
Pubmed	Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver.	FMO2 FMO3	1.64e-06	2	45	2	1542660
Pubmed	ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells.	ACTR3B ACTR3	1.64e-06	2	45	2	10806390
Pubmed	Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.	CYP2A6 CYP2A13	1.64e-06	2	45	2	12499123
Pubmed	Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.	CYP2A6 CYP2A13	1.64e-06	2	45	2	30222954
Pubmed	CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.	CYP2A6 CYP2A7	1.64e-06	2	45	2	16636685
Pubmed	Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.	CYP2A6 CYP2A13	1.64e-06	2	45	2	8611142
Pubmed	Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.	CYP2A6 CYP2A13	1.64e-06	2	45	2	7543189
Pubmed	Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.	CYP2A6 CYP2A13	1.64e-06	2	45	2	27902773
Pubmed	Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.	CYP2A6 CYP2A13	1.64e-06	2	45	2	22497566
Pubmed	Characterization and regulation of sex-specific mouse steroid hydroxylase genes.	CYP2A6 CYP2A13	1.64e-06	2	45	2	2372744
Pubmed	Coumarin toxicity in different strains of mice.	CYP2A6 CYP2A13	1.64e-06	2	45	2	665441
Pubmed	The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.	CYP2A6 CYP2A7	1.64e-06	2	45	2	2322567
Pubmed	Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.	CYP2A6 CYP2A13	1.64e-06	2	45	2	21473878
Pubmed	DUOX2-mediated production of reactive oxygen species induces epithelial mesenchymal transition in 5-fluorouracil resistant human colon cancer cells.	DUOX2 TET1	1.64e-06	2	45	2	29715584
Pubmed	Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.	CYP2A6 CYP2A13	1.64e-06	2	45	2	24104196
Pubmed	The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.	CYP2A6 CYP2A13	1.64e-06	2	45	2	7581481
Pubmed	The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.	CYP2A6 CYP2A13	1.64e-06	2	45	2	26363552
Pubmed	Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.	CYP2A6 CYP2A13	1.64e-06	2	45	2	30154104
Pubmed	Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.	CYP2A6 CYP2A13	1.64e-06	2	45	2	2712571
Pubmed	Molecular genetics of the human cytochrome P450 monooxygenase superfamily.	CYP2A6 CYP2A7 CYP2A13	2.27e-06	20	45	3	9890157
Pubmed	Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.	CYP2A6 CYP2A13	4.91e-06	3	45	2	18602936
Pubmed	Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.	CYP2A6 CYP2A13	4.91e-06	3	45	2	18068688
Pubmed	Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation.	DDX11L8 DDX11	4.91e-06	3	45	2	17611414
Pubmed	CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.	CYP2A6 CYP2A7	4.91e-06	3	45	2	11960914
Pubmed	Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.	CYP2A6 CYP2A13	4.91e-06	3	45	2	3219345
Pubmed	Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7.	CYP2A6 CYP2A13	4.91e-06	3	45	2	1973143
Pubmed	Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.	CYP2A6 CYP2A13	4.91e-06	3	45	2	7849402
Pubmed	A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression.	CYP2A6 CYP2A13	4.91e-06	3	45	2	21252290
Pubmed	Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.	CYP2A6 CYP2A13	4.91e-06	3	45	2	25478736
Pubmed	Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.	CYP2A6 CYP2A13	4.91e-06	3	45	2	20840855
Pubmed	Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site.	CYP2A6 CYP2A13	4.91e-06	3	45	2	17466327
Pubmed	Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway.	CYP2A6 CYP2A13	4.91e-06	3	45	2	22552773
Pubmed	CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.	CYP2A6 CYP2A7	4.91e-06	3	45	2	25710939
Pubmed	Nicotine-N'-Oxidation by Flavin Monooxygenase Enzymes.	FMO2 FMO3	4.91e-06	3	45	2	30381441
Pubmed	High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis.	CYP2A6 CYP2A13	4.91e-06	3	45	2	32877213
Pubmed	Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital.	CYP2A6 CYP2A13	4.91e-06	3	45	2	11106424
Pubmed	Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation.	CYP2A6 CYP2A13	4.91e-06	3	45	2	24191237
Pubmed	Mammalian ChlR1 has a role in heterochromatin organization.	DDX11L8 DDX11	4.91e-06	3	45	2	21854770
Pubmed	Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2.	CYP2A6 CYP2A13	4.91e-06	3	45	2	17303623
Pubmed	Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model.	CYP2A6 CYP2A13	4.91e-06	3	45	2	23073733
Pubmed	Resveratrol improves health and survival of mice on a high-calorie diet.	CYP2A6 CYP2A7 CYP2A13	5.15e-06	26	45	3	17086191
Pubmed	Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.	CYP2A6 FMO2 FMO3	5.79e-06	27	45	3	20173083
Pubmed	Analysis of RNA-protein interactions of mouse liver cytochrome P4502A5 mRNA.	CYP2A6 CYP2A13	9.81e-06	4	45	2	10215609
Pubmed	Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5.	CYP2A6 CYP2A13	9.81e-06	4	45	2	24494203
Pubmed	Non-thermal dielectric-barrier discharge plasma induces reactive oxygen species by epigenetically modifying the expression of NADPH oxidase family genes in keratinocytes.	DUOX2 TET1	9.81e-06	4	45	2	32863235
Pubmed	Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5.	CYP2A6 CYP2A13	9.81e-06	4	45	2	16183037
Pubmed	The genes for mouse salivary androgen-binding protein (ABP) subunits alpha and gamma are located on chromosome 7.	CYP2A6 CYP2A13	9.81e-06	4	45	2	3569880
Pubmed	Quantitative analysis of FMO gene mRNA levels in human tissues.	FMO2 FMO3	9.81e-06	4	45	2	16183778
Pubmed	DNA sequence polymorphism in an androgen-regulated gene is associated with alteration in the encoded RNAs.	CYP2A6 CYP2A13	9.81e-06	4	45	2	6188152
Pubmed	Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.	CYP2A6 CYP2A13	9.81e-06	4	45	2	22228748
Pubmed	The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression.	FMO2 FMO3	1.63e-05	5	45	2	8128486
Pubmed	Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine.	FMO2 FMO3	1.63e-05	5	45	2	32156684
Pubmed	A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities.	FMO2 FMO3	1.63e-05	5	45	2	8311461
Pubmed	Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China.	CYP2A6 CYP2A13	1.63e-05	5	45	2	19303722
Interaction	CYP2A7 interactions	CYP2A6 CYP2A7 CYP2A13	1.04e-08	3	45	3	int:CYP2A7
Cytoband	1q24.3	FMO2 FMO3	1.77e-04	20	45	2	1q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1q24	ADCY10 FMO2 FMO3	2.82e-04	129	45	3	chr1q24
Cytoband	19q13.2	CYP2A6 CYP2A7 CYP2A13	5.69e-04	164	45	3	19q13.2
Cytoband	7q36.1	CHPF2 ACTR3B	2.43e-03	74	45	2	7q36.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	AMIGO3 NBEAL2 TMEM115	3.70e-03	316	45	3	chr3p21
Cytoband	5q31	PCDHGC4 SMAD5	5.74e-03	115	45	2	5q31
GeneFamily	Cytochrome P450 family 2	CYP2A6 CYP2A7 CYP2A13	5.35e-05	35	38	3	1001
GeneFamily	CD molecules\|Type II classical cadherins	CDH5 CDH9	3.31e-04	13	38	2	1186
Coexpression	BOCHKIS_FOXA2_TARGETS	CYP2A6 CYP2A7 CYP2A13 FMO2 FMO3 CRKL ARHGAP12	1.38e-05	467	45	7	MM1233
Coexpression	WENG_POR_DOSAGE	CYP2A6 CYP2A7 CYP2A13	1.86e-05	30	45	3	MM1199
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A6 CYP2A7 CYP2A13 SERPINB10 EPG5	8.80e-07	174	45	5	42f2ba54b4ea4c62482582b0ccdadffae0a5eb4a
ToppCell	18-Distal-Epithelial-Secretory_progenitor\|Distal / Age, Tissue, Lineage and Cell class	ARFGEF3 CYP2A6 CYP2A7 CYP2A13 FMO2	1.43e-06	192	45	5	9fae988ecd2ef1231bfd42a678a4903517694cbe
ToppCell	normal_Lung-Epithelial_cells-Club\|normal_Lung / Location, Cell class and cell subclass	ARFGEF3 CYP2A6 CYP2A7 CYP2A13 FMO2	1.54e-06	195	45	5	b46544ad5af04f4dbc2643637caa3d2d50d922ae
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Club\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 CYP2A6 CYP2A7 CYP2A13 FMO2	1.58e-06	196	45	5	4e4c632db73b1340d80bf40a7657cb4821084d3c
ToppCell	Biopsy_Control_(H.)-Epithelial-SCGB3A2+_SCGB1A1+\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	ARFGEF3 CYP2A6 CYP2A7 CYP2A13 FMO2	1.66e-06	198	45	5	a3d4b6e4259ded2193d94d2ff6d48cf67214fc35
ToppCell	distal-1-Epithelial-Club\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ARFGEF3 CYP2A6 CYP2A7 CYP2A13 FMO2	1.70e-06	199	45	5	8f0a72a95d0310ef2324c6975495c294b5a47cc8
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Club\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	ARFGEF3 CYP2A6 CYP2A7 CYP2A13 FMO2	1.70e-06	199	45	5	111cfd589ec6795075d8d88d7664bfb23eba5bf6
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Club-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARFGEF3 CYP2A6 CYP2A7 CYP2A13 FMO2	1.70e-06	199	45	5	d583290a1d288b749ad17bc501c1487268c6551c
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Club\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ARFGEF3 CYP2A6 CYP2A7 CYP2A13 FMO2	1.70e-06	199	45	5	2b17694cffbec28a2c8f165dfcff6bab94aa0f4c
ToppCell	distal-Epithelial-Club-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ARFGEF3 CYP2A6 CYP2A7 CYP2A13 FMO2	1.70e-06	199	45	5	685cefbe6ff5db8b578e50b5849524ac2f347d0c
ToppCell	Club_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	ARFGEF3 CYP2A6 FMO2 FMO3	1.47e-05	147	45	4	5a824c89e4d045af465d7333275f8191fb29b041
ToppCell	Club_cells-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	CYP2A6 CYP2A13 FMO2 FMO3	2.26e-05	164	45	4	4e25e6362ef793b08de2f4d1dccb6b1fc9c072a5
ToppCell	Club_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	ZPBP2 FMO2 FMO3 DDX11	2.37e-05	166	45	4	a440aa338aa0c6cd0b5800dfa7e83f8ca16fce1a
ToppCell	Club_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	CYP2A6 CYP2A13 FMO2 FMO3	2.42e-05	167	45	4	dbdaaeb3bd9139cb008d9fe24ec031fc5628f136
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-TRGV2_gdT\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY10 ZNF619 AMIGO3 ADARB2	2.48e-05	168	45	4	2765d98f0b7f6861d662937535e051d41dba3500
ToppCell	Adult-Epithelial-club_cell-D122\|Adult / Lineage, Cell type, age group and donor	ARFGEF3 CYP2A6 CYP2A7 FMO2	3.11e-05	178	45	4	35a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCell	droplet-Bladder-BLADDER-1m-Endothelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAP1L3 FMO2 CDH5 TET1	3.11e-05	178	45	4	6bef4ef48f649c6e38ae732bc08e6d7814db588b
ToppCell	droplet-Fat-Gat-18m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DCHS1 CDH5 NBEAL2 DDX11	3.18e-05	179	45	4	08cf9986804a6417a9afb19b50c69a3554f71ec6
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FMO2 FMO3 ZFHX4 ADARB2	3.39e-05	182	45	4	8a8b08ac4bb3cba3541dbe234e088703842285b9
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FMO2 FMO3 ZFHX4 ADARB2	3.39e-05	182	45	4	e36766309c4d96a90d213ce37d3acef1029a3fdc
ToppCell	Control-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	CYP2A6 CYP2A7 CYP2A13 FMO2	3.61e-05	185	45	4	6814b3c94c7558443c038a227b5c8563d2cfeac4
ToppCell	Control-Epithelial-Club\|World / Disease state, Lineage and Cell class	ARFGEF3 CYP2A6 CYP2A7 FMO2	3.69e-05	186	45	4	9798428691408e17ff2af2fe2d1b345f074d67e4
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FMO2 FMO3 ZFHX4 ABCA8	3.69e-05	186	45	4	7582b5154d8e5a4434817b5ab77a10b789ea2288
ToppCell	Severe-Lymphoid-NK-Treg\|Severe / Condition, Lineage, Cell class and cell subclass	AMBRA1 SIRT3 CRKL DDX11	4.01e-05	190	45	4	e67803bf55a3f8e47a69ff1829c9100f870d7527
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DUOX2 CYP2A6 CYP2A13 FMO3	4.01e-05	190	45	4	2fdc024d3d673a0134b74b4c5a63afe924995730
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARFGEF3 CYP2A6 CYP2A7 FMO2	4.09e-05	191	45	4	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	IPF-Epithelial-Club\|World / Disease state, Lineage and Cell class	ARFGEF3 CYP2A6 CYP2A7 FMO2	4.09e-05	191	45	4	3c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCell	5'-Adult-LymphNode-Mesenchymal-fibroblastic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FMO2 FMO3 ZFHX4 ABCA8	4.18e-05	192	45	4	d7faa993f68e530ad55185505384ae155d36c222
ToppCell	Control-Epithelial-Club\|Control / Disease state, Lineage and Cell class	ARFGEF3 CYP2A6 CYP2A7 FMO2	4.18e-05	192	45	4	d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A6 CYP2A7 CYP2A13 FMO3	4.26e-05	193	45	4	605fc2a25ed6846fb283b2918cfed98df6039d6b
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARFGEF3 CYP2A6 CYP2A7 FMO2	4.26e-05	193	45	4	525e0de0f25f3308daf49e7d4c8774562f1f40ad
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-Secretory/RAS\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARFGEF3 CYP2A6 CYP2A7 FMO2	4.26e-05	193	45	4	2d18f39615043dfbff120a00f6540ffa93082c83
ToppCell	Club_cells\|World / lung cells shred on cell class, cell subclass, sample id	CYP2A6 CYP2A7 FMO2 DDX11	4.26e-05	193	45	4	9d3165dc5763a07a7d873f497624d9d6528fa2db
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	ARFGEF3 CYP2A6 CYP2A7 FMO2	4.26e-05	193	45	4	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	Club_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	CYP2A6 CYP2A7 FMO2 DDX11	4.26e-05	193	45	4	6582c0367052b9d10fb629c383ee0c55872afd2d
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARFGEF3 CYP2A6 CYP2A7 FMO2	4.35e-05	194	45	4	5b29c843186c2394f5bec3b1d5ae284a0d931d85
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARFGEF3 CYP2A6 CYP2A7 FMO2	4.35e-05	194	45	4	8c6e5ba27a988e0cd6b8c25cb9a30a0da2b1f7f9
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARFGEF3 CYP2A6 CYP2A7 FMO2	4.35e-05	194	45	4	a58841b34efe673671a9a059238e044a7254b279
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARFGEF3 CYP2A6 CYP2A7 FMO2	4.35e-05	194	45	4	6e78e3046c5b172af92a84e25f982377a0aaac58
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARFGEF3 CYP2A6 CYP2A7 FMO2	4.35e-05	194	45	4	0cd4363627acd419e00d6d32f6dce10430aa6487
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARFGEF3 CYP2A6 CYP2A7 FMO2	4.35e-05	194	45	4	ebcf6c6d0eb20a5d422becf5a730089230c8ba9a
ToppCell	Epithelial_cells-Club_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	CYP2A6 CYP2A7 FMO2 DDX11	4.44e-05	195	45	4	b758676abfc4e6930b696d270ecc0ea461b87a54
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARFGEF3 CYP2A6 CYP2A7 FMO2	4.44e-05	195	45	4	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FMO2 FMO3 ZFHX4 ABCA8	4.44e-05	195	45	4	783bfa8110161cbd6def50ce849cae676c39c458
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FMO2 FMO3 ZFHX4 ABCA8	4.44e-05	195	45	4	cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FMO2 FMO3 ZFHX4 ABCA8	4.53e-05	196	45	4	3a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCell	ILEUM-non-inflamed-(9)_Neuro_cell\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DCHS1 ZFHX4 ABCA8 DDX11	4.53e-05	196	45	4	2b08cd6730119d5dea0152709ab8de580b66cd3c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FMO2 FMO3 ZFHX4 ABCA8	4.53e-05	196	45	4	bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCell	ILEUM-non-inflamed-(9)_Enteric_neurons\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DCHS1 ZFHX4 ABCA8 DDX11	4.53e-05	196	45	4	998aa523555ed6bc9c1b5cacbf7ba77c7b218e6b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FMO2 FMO3 ZFHX4 ABCA8	4.62e-05	197	45	4	09946ee8dfb15a2a32da06e5b331f3277ee934f4
ToppCell	10x3'2.3-week_14-16-Mesenchymal_adipo-stroma-adipo-CAR\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FMO3 ZFHX4 ABCA8 SYT6	4.71e-05	198	45	4	a8c21f4db6730d0aa05b61fbe72bf9f7571a9015
ToppCell	10x3'2.3-week_14-16-Mesenchymal_adipo-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FMO3 ZFHX4 ABCA8 SYT6	4.71e-05	198	45	4	8b68fc887e5ad0a59ea4d93dfd1edda67030f142
ToppCell	3'-Adult-LymphNode-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FMO2 FMO3 ZFHX4 ABCA8	4.71e-05	198	45	4	abac765c4f6864bdb1700bc546c3b9771edc25c3
ToppCell	NS-critical-LOC-Epithelial-Secretory_LYPD2\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARFGEF3 DUOX2 CYP2A13 FMO3	4.71e-05	198	45	4	4a481e1edb80b950c823ed926842cd5132cfb27f
ToppCell	3'-Adult-LymphNode-Mesenchymal-fibroblastic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FMO2 FMO3 ZFHX4 ABCA8	4.71e-05	198	45	4	ff57addcbdd53e5d2d0c80ec76b5eab3b3a67ca2
ToppCell	normal_Lung-Epithelial_cells-Club\|Epithelial_cells / Location, Cell class and cell subclass	CYP2A6 CYP2A7 CYP2A13 FMO2	4.71e-05	198	45	4	a9d0109ca05eb3e9c588f9677ec471dd5c092a75
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Club\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ARFGEF3 CYP2A6 CYP2A13 FMO2	4.71e-05	198	45	4	5d57acbe0d245f8bd217eeea07af060092898fbd
ToppCell	10x3'2.3-week_14-16-Mesenchymal_adipo\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FMO3 ZFHX4 ABCA8 SYT6	4.71e-05	198	45	4	4739b2e4ab141c66772e61686b45614a1839483e
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A7 CYP2A13 FMO3 ZFHX4	4.71e-05	198	45	4	e3d1c9428ee6f9bcf9cdaf2192d4ebea8cc2a47c
ToppCell	3'-Adult-LymphNode-Mesenchymal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FMO2 FMO3 ZFHX4 ABCA8	4.71e-05	198	45	4	698166b4ca173176ed563af6a1efc8c7d0a18e0b
ToppCell	stromal_cell\|World / Lineage and Cell class	FMO2 FMO3 ZFHX4 ABCA8	4.80e-05	199	45	4	507a82d0529b5b1fa5aebcfe43db53f0b6e3f8f0
ToppCell	stromal_cell-stromal_cell\|World / Lineage and Cell class	FMO2 FMO3 ZFHX4 ABCA8	4.80e-05	199	45	4	74262363a34da3a1eb55ab375fd61ddd7bb39b23
ToppCell	distal-Epithelial-Club\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ARFGEF3 CYP2A6 CYP2A7 FMO2	4.80e-05	199	45	4	c63ccce1285352927fd8c4f7374ec5fff8d70cec
ToppCell	Biopsy_IPF-Epithelial-SCGB3A2+_SCGB1A1+\|Biopsy_IPF / Sample group, Lineage and Cell type	ARFGEF3 CYP2A6 CYP2A13 FMO2	4.80e-05	199	45	4	c6150f5fe2ce4466149a4d553acb907034a72efb
ToppCell	cellseq2-Mesenchymal-Fibroblastic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FMO2 FMO3 ZFHX4 ABCA8	4.89e-05	200	45	4	1c10597edd532bf172ca09870a937d35e2585081
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FMO2 FMO3 ZFHX4 ABCA8	4.89e-05	200	45	4	440dda48b09c6a8581b7ca634b0d67f1ecacf65e
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FMO2 FMO3 ZFHX4 ABCA8	4.89e-05	200	45	4	44317fbf4d1480a37b50ab2777bf1a3e4fc0c05f
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_AB-3\|TCGA-Thymus / Sample_Type by Project: Shred V9	CYP2A7 PCDHGC4 SYT6	1.54e-04	103	45	3	91fe062dcadd12fdb04fa4593a794c57f3f0411d
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_A2\|390C / Donor, Lineage, Cell class and subclass (all cells)	AMBRA1 ZNF619 UBE2Q2	1.92e-04	111	45	3	dfbdeadad321392d359e6fb7112b28b043a4b874
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-6\|TCGA-Thryoid / Sample_Type by Project: Shred V9	DUOX2 GNAS ABCA8	3.20e-04	132	45	3	b7611c6a5c86908132e7ab3e41d67277e8142db1
ToppCell	RV-14._Fibroblast_III\|World / Chamber and Cluster_Paper	FMO2 ABCA8 CDH9	3.34e-04	134	45	3	8c4046ba1f85172915a112499e492c3efe8474c2
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Mucinous_Carcinoma-1\|TCGA-Breast / Sample_Type by Project: Shred V9	CYP2A6 CYP2A7 CYP2A13	4.21e-04	145	45	3	1e52e3c615b49e7388cd58a04e74cafac9552447
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	FMO2 SGMS1 CDH5	4.56e-04	149	45	3	d9c47f523c75ddcd6131e45d2ffc24b970932cae
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MARCHF10 ADARB2 CDH9	4.65e-04	150	45	3	47ea08d7609e1d2382bf56ef9e5c767e3597cf93
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A6 CYP2A13 FMO3	5.31e-04	157	45	3	c43f2e1ea53b375a7432f17f87cfef3b2261003d
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-FB-1\|E18.5-samps / Age Group, Lineage, Cell class and subclass	NAP1L3 FMO2 AMIGO3	5.51e-04	159	45	3	b4bc888e978b1b577721b891b0af6ba9a1607044
ToppCell	Club_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	ARFGEF3 CYP2A6 FMO2	5.51e-04	159	45	3	a7bcff268b1962a561fd2848e01ae16565bce895
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	FMO2 ABCA8 NBEAL2	5.61e-04	160	45	3	58ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCell	Club_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	CYP2A13 FMO3 DDX11	5.72e-04	161	45	3	bd08a23b415617f6e8748ed2668d578a860ecf91
ToppCell	PND07-Endothelial-Endothelial_lymphatic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DUOX2 GNAS ZFHX4	5.72e-04	161	45	3	133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DUOX2 GNAS ZFHX4	5.72e-04	161	45	3	cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DUOX2 GNAS ZFHX4	5.72e-04	161	45	3	9466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCell	Club_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	CYP2A13 FMO2 AMIGO3	5.72e-04	161	45	3	342f5c61d37df61b35c18f5d258043a8f5cef629
ToppCell	AT1_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	CYP2A6 FMO2 ABCA8	5.82e-04	162	45	3	ae2ba4f21f6f6c512006fa531d670b88be7c04c9
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP2A6 CYP2A13 ADARB2	5.82e-04	162	45	3	112fa4de685727f6c8bf6fc4afb82de0524070ad
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARFGEF3 CYP2A6 CYP2A7	5.82e-04	162	45	3	5c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DUOX2 GNAS ZFHX4	5.82e-04	162	45	3	96c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCell	E12.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GNAS CDH5 NBEAL2	5.92e-04	163	45	3	c21114826bee1b05b411984326fef6b6e0d05316
ToppCell	E12.5-Endothelial-lymphatic_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GNAS CDH5 NBEAL2	5.92e-04	163	45	3	5d49414432db259a19df50d7944581d00b69f537
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_TNFAIP8L3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADARB2 DDX11L8 SYT6	6.14e-04	165	45	3	cd73bba51f3f4871533c3512bdc0a1f05716344b
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Lymphocytic-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TET1 SYT6 DDX11	6.14e-04	165	45	3	475905d608fac628960188ae4a18010b8097417e
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 FMO2 SYT6	6.25e-04	166	45	3	1df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 FMO2 SYT6	6.25e-04	166	45	3	9628522e7af8f8edca733588a364ab2454ac5ca5
ToppCell	Posterior_cortex-Neuronal-Inhibitory\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	GNAS ADARB2 CDH9	6.36e-04	167	45	3	9a84f45345c75f2c8ff38a04245aadee2a26a240
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-4\|TCGA-Liver / Sample_Type by Project: Shred V9	GNAS MAPK13 TET1	6.58e-04	169	45	3	0a3ba6b5d6cff9d3d7f56046063cfc3a37ae1156
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GNAS ADARB2 SYT6	6.58e-04	169	45	3	c135d7ae0490d0024e0f4bd8c4ad42f6674a61da
ToppCell	RA-01._Fibroblast_I\|RA / Chamber and Cluster_Paper	DUOX2 FMO2 ABCA8	6.58e-04	169	45	3	6373562ab3b1765060212a6a53d6543e7e942e80
ToppCell	Ciliated_cells-A-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	CYP2A6 CYP2A7 FMO2	6.69e-04	170	45	3	3d3a03979014df3a05c49be18010c6b94d786707
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Goblet-Goblet\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP2A7 CYP2A13 AMIGO3	6.81e-04	171	45	3	25c1979e972c959e1ce4c57804f976f53a247ad7
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_DISP2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SERPINB10 ADARB2 SYT6	6.81e-04	171	45	3	4e8460d821aabf26f6a3a5957b22d561113e107f
Drug	2'-methoxyacetophenone	CYP2A6 CYP2A7 CYP2A13	6.73e-09	3	44	3	CID000068481
Drug	N,N-dimethylaniline	CYP2A7 CYP2A13 FMO2 FMO3	1.29e-06	42	44	4	CID000000949
Drug	N-nitrosomethylaniline	CYP2A6 CYP2A7 CYP2A13	2.41e-06	14	44	3	CID000011957
Drug	nicotine imine	CYP2A6 CYP2A13	3.65e-06	2	44	2	ctd:C034629
Drug	propargyl ether	CYP2A6 CYP2A13	3.65e-06	2	44	2	ctd:C531209
Drug	alpha-nicotyrine	CYP2A6 CYP2A13	3.65e-06	2	44	2	ctd:C008615
Drug	Hempa	CYP2A6 CYP2A13	3.65e-06	2	44	2	ctd:D006492
Drug	N-nitrosoguvacoline	CYP2A6 CYP2A13	3.65e-06	2	44	2	ctd:C036676
Drug	chlorzoxazone	CYP2A6 CYP2A7 CYP2A13 FMO3	6.65e-06	63	44	4	CID000002733
Drug	piperonyl butoxide	CYP2A6 CYP2A7 CYP2A13 FMO2	8.51e-06	67	44	4	CID000005794
Drug	NSC35549	CYP2A6 CYP2A7 CYP2A13	1.01e-05	22	44	3	CID000411697
Drug	1h1q	CYP2A6 CYP2A7 CYP2A13 FMO3	1.01e-05	70	44	4	CID000001540
Drug	C14845	CYP2A6 CYP2A7 CYP2A13	1.91e-05	27	44	3	CID011954064
Drug	BP-9,10-oxide	CYP2A6 CYP2A7 CYP2A13	1.91e-05	27	44	3	CID000037456
Drug	Brn 4136738	CYP2A6 CYP2A7 CYP2A13	1.91e-05	27	44	3	CID000050331
Drug	9-OH-BaP-4,5-oxide	CYP2A6 CYP2A7 CYP2A13	2.13e-05	28	44	3	CID000115064
Drug	Benzydamine	FMO2 FMO3	2.18e-05	4	44	2	ctd:D001591
Drug	NMPA	CYP2A6 CYP2A13	2.18e-05	4	44	2	CID000132101
Drug	N'-nitrosoanatabine	CYP2A6 CYP2A13	2.18e-05	4	44	2	ctd:C032978
Drug	trans-3'-hydroxycotinine	CYP2A6 CYP2A13 FMO3	2.38e-05	29	44	3	CID000000414
Drug	nogalonic acid methyl ester	CYP2A6 CYP2A13 FMO3 GNAS	2.40e-05	87	44	4	CID000443820
Drug	metyrapone	CYP2A6 CYP2A7 CYP2A13 FMO3 GNAS	2.41e-05	179	44	5	CID000004174
Drug	14(15)-EpETrE	CYP2A6 CYP2A7 CYP2A13 GNAS	2.63e-05	89	44	4	CID000001431
Drug	11-H-14,15-EETA	CYP2A6 CYP2A7 CYP2A13	2.64e-05	30	44	3	CID011954058
Drug	19-hydroxytestosterone	CYP2A6 CYP2A7 CYP2A13	2.64e-05	30	44	3	CID000150968
Drug	AC1L1BEQ	CYP2A6 CYP2A7 CYP2A13 GNAS	3.12e-05	93	44	4	CID000001407
Drug	BP-7,8-oxide	CYP2A6 CYP2A7 CYP2A13	3.21e-05	32	44	3	CID000037455
Drug	N-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide	CYP2A6 CYP2A13	3.64e-05	5	44	2	ctd:C062567
Drug	Ccris 2188	FMO2 FMO3	3.64e-05	5	44	2	CID000146896
Drug	benzyl selenocyanate	CYP2A6 CYP2A13	3.64e-05	5	44	2	ctd:C054108
Drug	S)-cotinine	CYP2A6 CYP2A7 CYP2A13 FMO3	3.69e-05	97	44	4	CID000000408
Drug	Isoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Down 200; 16.4uM; HL60; HT_HG-U133A	AMBRA1 MAPK13 SIRT3 CRKL SMAD5	3.81e-05	197	44	5	2463_DN
Drug	12(13)-EpOME	CYP2A6 CYP2A7 CYP2A13	3.86e-05	34	44	3	CID000001416
Drug	TCEO	CYP2A6 CYP2A7 CYP2A13	3.86e-05	34	44	3	CID000028167
Drug	AC1O5XSP	CYP2A6 CYP2A7 CYP2A13	3.86e-05	34	44	3	CID006442739
Drug	AC1L1CJI	CYP2A6 CYP2A7 CYP2A13	4.22e-05	35	44	3	CID000001929
Drug	DEET	DUOX2 CYP2A6 CYP2A7 CYP2A13 FMO2	4.49e-05	204	44	5	ctd:D003671
Drug	15-H-11,12-EETA	CYP2A6 CYP2A7 CYP2A13	4.60e-05	36	44	3	CID011954042
Drug	AC1L3NGJ	CYP2A6 CYP2A7 CYP2A13	4.60e-05	36	44	3	CID000092121
Drug	hexamethylphosphoramide	CYP2A6 CYP2A7 CYP2A13	4.60e-05	36	44	3	CID000012679
Drug	acenaphthene-1-ol	CYP2A6 CYP2A13	5.45e-05	6	44	2	ctd:C023723
Drug	AC1L196J	CYP2A6 CYP2A13	5.45e-05	6	44	2	CID000000415
Drug	menthofuran	CYP2A6 CYP2A13	5.45e-05	6	44	2	ctd:C054487
Drug	N'-nitrosoanabasine	CYP2A6 CYP2A13	5.45e-05	6	44	2	ctd:C010257
Drug	11,14,15-THET	CYP2A6 CYP2A7 CYP2A13	5.86e-05	39	44	3	CID006439531
Drug	11,12,15-trihydroxyeicosatrienoic acid	CYP2A6 CYP2A7 CYP2A13	7.33e-05	42	44	3	CID006439610
Drug	acenaphthene	CYP2A6 CYP2A13	7.62e-05	7	44	2	ctd:C042552
Drug	N,N-dimethylaniline	CYP2A13 FMO2	7.62e-05	7	44	2	ctd:C015157
Drug	polybrominated biphenyl	CYP2A6 CYP2A7 CYP2A13	8.44e-05	44	44	3	CID000042948
Drug	naphthalene-1,2-dihydrodiol	CYP2A6 CYP2A7 CYP2A13	9.03e-05	45	44	3	CID000000362
Drug	naphthalene	CYP2A6 CYP2A7 CYP2A13 TMEM115	9.32e-05	123	44	4	CID000000931
Drug	methimazole	DUOX2 CYP2A6 FMO2 FMO3	1.02e-04	126	44	4	CID001349907
Drug	C14802	CYP2A6 CYP2A7 CYP2A13	1.03e-04	47	44	3	CID011954053
Drug	C14800	CYP2A6 CYP2A7 CYP2A13	1.10e-04	48	44	3	CID011954051
Drug	nitro-L	CYP2A6 CYP2A7 CYP2A13	1.10e-04	48	44	3	CID000006849
Drug	19-HETE	CYP2A6 CYP2A7 CYP2A13	1.17e-04	49	44	3	CID006439528
Drug	bromobenzene-3,4-oxide	CYP2A6 CYP2A7 CYP2A13	1.17e-04	49	44	3	CID000108121
Drug	bromobenzene-2,3-oxide	CYP2A6 CYP2A7 CYP2A13	1.24e-04	50	44	3	CID003036760
Drug	6-hydroxymelatonin	CYP2A6 CYP2A7 CYP2A13	1.24e-04	50	44	3	CID000001864
Drug	1,1-dichloroethylene epoxide	CYP2A6 CYP2A7 CYP2A13	1.24e-04	50	44	3	CID000119521
Drug	N-nitrosoguvacoline	CYP2A6 CYP2A13	1.30e-04	9	44	2	CID000062103
Drug	3-(methylnitrosamino)propionaldehyde	CYP2A6 CYP2A13	1.30e-04	9	44	2	CID000098533
Drug	TCVC	FMO2 FMO3	1.30e-04	9	44	2	CID000108091
Drug	acenaphthylene	CYP2A6 CYP2A13	1.30e-04	9	44	2	ctd:C042553
Drug	naphthalene epoxide	CYP2A6 CYP2A7 CYP2A13	1.31e-04	51	44	3	CID000108063
Drug	mepivacaine	CYP2A6 CYP2A7 CYP2A13	1.31e-04	51	44	3	CID000004062
Drug	9-hydroxybenzo(a)pyrene	CYP2A6 CYP2A7 CYP2A13	1.47e-04	53	44	3	CID000028598
Drug	paraxanthine	CYP2A6 CYP2A13 FMO3	1.47e-04	53	44	3	CID000004687
Drug	dichloroacetaldehyde	CYP2A6 CYP2A7 CYP2A13	1.56e-04	54	44	3	CID000006576
Drug	aniline	CYP2A6 CYP2A7 CYP2A13 SERPINB10	1.62e-04	142	44	4	CID000006115
Drug	chloroacetyl chloride	CYP2A6 CYP2A7 CYP2A13	1.65e-04	55	44	3	CID000006577
Drug	1,2-dihydroxynaphthalene	CYP2A6 CYP2A7 CYP2A13	1.83e-04	57	44	3	CID000011318
Drug	bromoacetaldehyde	CYP2A6 CYP2A7 CYP2A13	1.93e-04	58	44	3	CID000105131
Drug	D-702	CYP2A6 CYP2A13	1.99e-04	11	44	2	CID000054077
Drug	N,N-dimethylaniline-N-oxide	FMO2 FMO3	1.99e-04	11	44	2	CID000000950
Drug	1,1-dichloroethylene	CYP2A6 CYP2A7 CYP2A13	2.13e-04	60	44	3	CID000006366
Drug	BP-4,5-oxide	CYP2A6 CYP2A7 CYP2A13	2.24e-04	61	44	3	CID000037786
Drug	p-tolyl sulfoxide	FMO2 FMO3	2.38e-04	12	44	2	CID000015680
Drug	pentaethylenehexamine	GNAS SGMS1	2.38e-04	12	44	2	CID000019990
Drug	nicotine-N'-oxide	CYP2A6 FMO3	2.38e-04	12	44	2	CID000000409
Drug	Skatole	CYP2A6 CYP2A13	2.81e-04	13	44	2	ctd:D012862
Drug	d 6-20	CYP2A6 CYP2A13	2.81e-04	13	44	2	CID000161569
Drug	propoxyphene	CYP2A6 CYP2A7 CYP2A13	2.96e-04	67	44	3	CID000010100
Drug	5,6-epoxyeicosatrienoic acid	CYP2A6 CYP2A7 CYP2A13	3.09e-04	68	44	3	CID000001778
Drug	8(9)-EET	CYP2A6 CYP2A7 CYP2A13	3.23e-04	69	44	3	CID000001901
Drug	MnPN	CYP2A6 CYP2A13	3.27e-04	14	44	2	CID000062163
Drug	methyl p-tolyl sulfide	FMO2 FMO3	3.27e-04	14	44	2	CID000069334
Drug	4-bromophenol	CYP2A6 CYP2A7 CYP2A13	3.37e-04	70	44	3	CID000007808
Drug	beta-NADP	DUOX2 CYP2A6 CYP2A7 CYP2A13 FMO2 FMO3	3.40e-04	490	44	6	CID000000929
Drug	1-aminobenzotriazole	CYP2A6 CYP2A13 FMO3	3.51e-04	71	44	3	CID000001367
Drug	1,2-dibromoethane	CYP2A6 CYP2A7 CYP2A13	3.51e-04	71	44	3	CID000007839
Drug	carteolol	CYP2A6 CYP2A7 CYP2A13	3.66e-04	72	44	3	CID000002583
Drug	oxygen	DUOX2 CYP2A6 CYP2A7 CYP2A13 FMO2 FMO3	3.75e-04	499	44	6	CID000000977
Drug	N'-nitrosonornicotine	CYP2A6 CYP2A13	3.77e-04	15	44	2	ctd:C008655
Drug	2,2,2-trichloroethanol	CYP2A6 CYP2A7 CYP2A13	3.81e-04	73	44	3	CID000008259
Drug	chloral	CYP2A6 CYP2A7 CYP2A13	3.81e-04	73	44	3	CID000006407
Drug	7-hydroxycoumarin	CYP2A6 CYP2A7 CYP2A13	4.13e-04	75	44	3	CID005281426
Drug	debrisoquine	CYP2A6 CYP2A7 CYP2A13	4.13e-04	75	44	3	CID000002965
Drug	C20H32O4	CYP2A6 CYP2A7 CYP2A13	4.63e-04	78	44	3	CID000001440
Drug	BP-7,8-diol	CYP2A6 CYP2A7 CYP2A13	4.63e-04	78	44	3	CID000025892
Disease	Warsaw breakage syndrome (implicated_via_orthology)	DDX11L8 DDX11	6.82e-06	3	45	2	DOID:0060535 (implicated_via_orthology)
Disease	Liver Diseases, Parasitic	CYP2A6 GNAS	8.13e-05	9	45	2	C0023897
Disease	nicotine metabolite ratio	CYP2A6 CYP2A7	1.49e-04	12	45	2	EFO_0007794
Disease	esophageal carcinoma, gastric carcinoma	MAST2 EPG5	3.05e-04	17	45	2	EFO_0000178, EFO_0002916
Disease	caffeine metabolite measurement	CYP2A6 CYP2A7	3.83e-04	19	45	2	EFO_0007872
Disease	Colorectal Carcinoma	DCHS1 CYP2A6 GNAS ADARB2 CDH5 ABCA8	6.56e-04	702	45	6	C0009402
Disease	Alcoholic Intoxication, Chronic	ZCCHC14 CYP2A13 CDH5 CDH9	7.40e-04	268	45	4	C0001973
Disease	pack-years measurement, systolic blood pressure	DCHS1 ADARB2	1.24e-03	34	45	2	EFO_0006335, EFO_0006526

Protein segments in the cluster

Peptide	Gene	Start	Entry
SPFFTPNAAPAEFIQ	EPG5	1731	Q9HCE0
DPSFFSNPQDFNPQH	CYP2A6	401	P11509
FLGPEIFFHPEFANP	ACTR3B	276	Q9P1U1
NFLKPPPNFNFDEFF	ADCY10	216	Q96PN6
VHFPRPEPEAFNTGF	AMIGO3	371	Q86WK7
FSFVQTEPFHPPEQA	AMBRA1	341	Q9C0C7
VDEPPIFQQPFYHFQ	CDH5	366	P33151
QADFPDTLFQEFEPP	ADARB2	216	Q9NS39
PVFLAPAFHFQVPEG	DCHS1	2811	Q96JQ0
QFFFRPFSPDPEVQM	OR10V1	11	Q8NGI7
DFPFPDDFPNFMHNS	FMO3	71	P31513
FLPENSFPSRFQPFQ	MMS19	691	Q96T76
SITHFGRPPFEPFFN	DUOX2	1486	Q9NRD8
PFPPHEFFNYNPVED	PCED1A	351	Q9H1Q7
QALTHPFFEPFRDPE	MAPK13	301	O15264
NPPSFFQRSHEVFVP	PCDHGC4	451	Q9Y5F7
FPFTHVKIFDPQNPD	CRKL	286	P46109
IHFPFPFTPYSIQED	DDX11	11	Q96FC9
ELPEPLFTFNHFNDF	ARHGAP12	736	Q8IWW6
FLGPEIFFHPEFANP	ACTR3	276	P61158
IFFHPEFANPDFTQP	ACTR3	281	P61158
DPRFFSNPRDFNPQH	CYP2A13	401	Q16696
DPSFFSNPQDFNPQH	CYP2A7	401	P20853
EPPHFHFNEALFRPF	ARFGEF3	1246	Q5TH69
IHFPFPFTPYSIQED	DDX11L8	11	A8MPP1
NVPDFDFPPEFYEHA	GNAS	136	P63092
QENTPFTFFAVSHFP	MARCHF10	596	Q8NA82
RNFSPNAPAHFSFVP	MAST2	206	Q6P0Q8
DFPMPEDFPNFLHNS	FMO2	71	Q99518
HKFFFEPVPEFTLNP	CDH9	521	Q9ULB4
NPTFDENFHFPVPYE	SYT6	291	Q5T7P8
FPPAALPQEFSAFFQ	NBEAL2	171	Q6ZNJ1
ELPFFFHNPKPFFTL	SIRT3	181	Q9NTG7
PRVVPNASFFNFFSP	NAP1L3	431	Q99457
ATFPDSFHQPNNTPF	SMAD5	171	Q99717
QNFGQFCPHDFPTVF	TET1	1196	Q8NFU7
PSFHDSFEQAPPEFQ	ABCA8	461	O94911
QAFFPVHFQEFNPAL	CHPF2	616	Q9P2E5
NFSFKDNFPFDPPFV	UBE2Q2	271	Q8WVN8
AAFFQPQFLNPAFLP	ZFHX4	1661	Q86UP3
HFAFATFFPEILQPV	TMEM115	221	Q12893
QPPLPDTFFDHFNRV	SGMS1	166	Q86VZ5
QHPFSGPSVFTFPFL	ZCCHC14	811	Q8WYQ9
SPVQIAHFFQDLAFP	ZNF619	531	Q8N2I2
PSIEFNANHPFLFFI	SERPINB10	366	P48595
HELFIAFQVNPFAPG	ZPBP2	201	Q6X784