Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF449 ZNF17 ZNF134 ZNF668 ZNF845 ZNF776 ZFP90 ZBTB39 ZNF354A ZNF493 ZNF530 ZSCAN22 KLF6 GLI1 GLI3 ZNF423 ZNF655 ZFP30 ZSCAN9 ZNF485 ZNF267 ZNF521 ZNF888 ZNF761 E4F1 ZNF772 ZNF699 ZNF25 ZNF354B SNAI3 ZNF491 ZFP62 ZNF646	2.30e-26	1412	50	33	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF449 ZNF17 ZNF134 ZNF668 ZNF845 ZNF776 ZFP90 ZBTB39 ZNF354A ZNF493 ZNF530 ZSCAN22 KLF6 GLI1 GLI3 ZNF423 ZNF655 ZFP30 ZSCAN9 ZNF485 ZNF267 ZNF521 ZNF888 ZNF761 E4F1 ZNF772 ZNF699 ZNF25 ZNF354B SNAI3 ZNF491 ZFP62 ZNF646	6.58e-26	1459	50	33	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF449 ZNF17 ZNF134 ZNF668 ZNF845 ZNF776 ZBTB39 ZNF354A ZNF493 ZNF530 ZSCAN22 KLF6 GLI1 GLI3 ZNF423 ZNF655 ZFP30 ZSCAN9 ZNF485 ZNF267 ZNF521 ZNF888 ZNF761 E4F1 ZNF772 ZNF699 ZNF354B SNAI3 ZFP62 ZNF646	6.87e-24	1244	50	30	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF449 ZNF17 ZNF134 ZNF668 ZNF845 ZNF776 ZBTB39 ZNF354A ZNF493 ZNF530 ZSCAN22 KLF6 GLI1 GLI3 ZNF423 ZNF655 ZFP30 ZSCAN9 ZNF485 ZNF267 ZNF521 ZNF888 ZNF761 E4F1 ZNF772 ZNF699 ZNF354B SNAI3 ZFP62 ZNF646	1.28e-23	1271	50	30	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF668 ZNF845 ZNF493 KLF6 GLI1 ZNF485 ZNF267 ZNF521 E4F1 ZNF699 ZFP62	1.06e-07	560	50	11	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF668 ZNF845 ZNF493 KLF6 GLI1 ZNF485 ZNF267 ZNF521 E4F1 ZNF699 ZFP62	1.18e-07	566	50	11	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF134 ZNF668 ZFP90 ZBTB39 ZNF493 E4F1 ZNF699 SNAI3	1.19e-06	320	50	8	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF134 ZNF668 ZFP90 ZBTB39 ZNF493 E4F1 ZNF699 SNAI3	1.37e-06	326	50	8	GO:0001217
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	ZNF462 ZNF668 ZNF845 ZNF493 KLF6 MICAL2 GLI1 GLI3 ZNF485 ZNF267 ZNF521 E4F1 ZFP62 ZNF646	2.69e-06	1390	49	14	GO:0045944
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	ZNF134 ZNF668 ZFP90 ZBTB39 ZNF354A ZNF493 GLI3 E4F1 ZNF699 ZNF354B SNAI3	2.84e-05	1053	49	11	GO:0000122
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	ZNF134 ZNF668 ZFP90 ZBTB39 ZNF354A ZNF493 GLI3 ZNF423 E4F1 ZNF699 ZNF354B SNAI3	7.94e-05	1399	49	12	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	ZNF134 ZNF668 ZFP90 ZBTB39 ZNF354A ZNF493 GLI3 ZNF423 E4F1 ZNF699 ZNF354B SNAI3	8.74e-05	1413	49	12	GO:1902679
GeneOntologyCellularComponent	GLI-SUFU complex	GLI1 GLI3	3.35e-05	4	50	2	GO:1990788
Domain	-	ZNF449 ZNF462 ZNF17 ZNF134 ZNF668 ZNF845 ZNF776 ZFP90 ZBTB39 ZNF354A ZNF493 ZNF530 ZSCAN22 KLF6 GLI1 GLI3 ZNF423 ZNF655 ZFP30 ZSCAN9 ZNF485 ZNF267 ZNF521 ZNF761 E4F1 ZNF772 ZNF699 ZNF285 ZNF25 ZNF354B SNAI3 ZNF491 ZFP62 ZNF646	4.81e-38	679	49	34	3.30.160.60
Domain	ZINC_FINGER_C2H2_2	ZNF449 ZNF462 ZNF17 ZNF134 ZNF668 ZNF137P ZNF845 ZNF776 ZFP90 ZBTB39 ZNF354A ZNF493 ZNF530 ZSCAN22 KLF6 GLI1 GLI3 ZNF423 ZNF655 ZFP30 ZSCAN9 ZNF485 ZNF267 ZNF521 ZNF761 E4F1 ZNF772 ZNF699 ZNF285 ZNF25 ZNF354B SNAI3 ZNF491 ZFP62 ZNF646	7.86e-38	775	49	35	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF449 ZNF462 ZNF17 ZNF134 ZNF668 ZNF137P ZNF845 ZNF776 ZFP90 ZBTB39 ZNF354A ZNF493 ZNF530 ZSCAN22 KLF6 GLI1 GLI3 ZNF423 ZNF655 ZFP30 ZSCAN9 ZNF485 ZNF267 ZNF521 ZNF761 E4F1 ZNF772 ZNF699 ZNF285 ZNF25 ZNF354B SNAI3 ZNF491 ZFP62 ZNF646	8.60e-38	777	49	35	PS00028
Domain	zf-C2H2	ZNF449 ZNF462 ZNF17 ZNF134 ZNF668 ZNF137P ZNF845 ZNF776 ZFP90 ZBTB39 ZNF354A ZNF493 ZNF530 ZSCAN22 KLF6 GLI1 ZNF423 ZNF655 ZFP30 ZSCAN9 ZNF485 ZNF267 ZNF521 ZNF761 E4F1 ZNF772 ZNF699 ZNF285 ZNF25 ZNF354B SNAI3 ZNF491 ZFP62 ZNF646	9.68e-38	693	49	34	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF449 ZNF462 ZNF17 ZNF134 ZNF668 ZNF845 ZNF776 ZFP90 ZBTB39 ZNF354A ZNF493 ZNF530 ZSCAN22 KLF6 GLI1 GLI3 ZNF423 ZNF655 ZFP30 ZSCAN9 ZNF485 ZNF267 ZNF521 ZNF761 E4F1 ZNF772 ZNF699 ZNF285 ZNF25 ZNF354B SNAI3 ZNF491 ZFP62 ZNF646	1.02e-37	694	49	34	IPR013087
Domain	Znf_C2H2	ZNF449 ZNF462 ZNF17 ZNF134 ZNF668 ZNF137P ZNF845 ZNF776 ZFP90 ZBTB39 ZNF354A ZNF493 ZNF530 ZSCAN22 KLF6 GLI1 GLI3 ZNF423 ZNF655 ZFP30 ZSCAN9 ZNF485 ZNF267 ZNF521 ZNF761 E4F1 ZNF772 ZNF699 ZNF285 ZNF25 ZNF354B SNAI3 ZNF491 ZFP62 ZNF646	2.99e-37	805	49	35	IPR007087
Domain	ZnF_C2H2	ZNF449 ZNF462 ZNF17 ZNF134 ZNF668 ZNF137P ZNF845 ZNF776 ZFP90 ZBTB39 ZNF354A ZNF493 ZNF530 ZSCAN22 KLF6 GLI1 GLI3 ZNF423 ZNF655 ZFP30 ZSCAN9 ZNF485 ZNF267 ZNF521 ZNF761 E4F1 ZNF772 ZNF699 ZNF285 ZNF25 ZNF354B SNAI3 ZNF491 ZFP62 ZNF646	3.41e-37	808	49	35	SM00355
Domain	Znf_C2H2-like	ZNF449 ZNF462 ZNF17 ZNF134 ZNF668 ZNF845 ZNF776 ZFP90 ZBTB39 ZNF354A ZNF493 ZNF530 ZSCAN22 KLF6 GLI1 GLI3 ZNF423 ZNF655 ZFP30 ZSCAN9 ZNF485 ZNF267 ZNF521 ZNF761 E4F1 ZNF772 ZNF699 ZNF285 ZNF25 ZNF354B SNAI3 ZNF491 ZFP62 ZNF646	1.10e-35	796	49	34	IPR015880
Domain	zf-C2H2_6	ZNF449 ZNF17 ZNF668 ZNF845 ZFP90 ZNF354A ZNF493 ZNF530 ZSCAN22 ZNF423 ZFP30 ZSCAN9 ZNF267 ZNF521 ZNF761 E4F1 ZNF699 ZNF25 ZNF354B ZFP62 ZNF646	7.14e-25	314	49	21	PF13912
Domain	KRAB	ZNF17 ZNF845 ZNF776 ZFP90 ZNF354A ZNF530 ZFP30 ZNF485 ZNF267 ZNF761 ZNF772 ZNF699 ZNF285 ZNF25 ZNF354B	1.13e-14	358	49	15	PS50805
Domain	KRAB	ZNF17 ZNF845 ZNF776 ZFP90 ZNF354A ZNF530 ZFP30 ZNF485 ZNF267 ZNF761 ZNF772 ZNF699 ZNF285 ZNF25 ZNF354B	1.13e-14	358	49	15	PF01352
Domain	KRAB	ZNF17 ZNF845 ZNF776 ZFP90 ZNF354A ZNF530 ZFP30 ZNF485 ZNF267 ZNF761 ZNF772 ZNF699 ZNF285 ZNF25 ZNF354B	1.76e-14	369	49	15	SM00349
Domain	KRAB	ZNF17 ZNF845 ZNF776 ZFP90 ZNF354A ZNF530 ZFP30 ZNF485 ZNF267 ZNF761 ZNF772 ZNF699 ZNF285 ZNF25 ZNF354B	1.83e-14	370	49	15	IPR001909
Domain	zf-C2H2_11	ZNF354A ZNF354B	2.40e-04	9	49	2	PF16622
Domain	SCAN	ZNF449 ZSCAN22 ZSCAN9	4.27e-04	56	49	3	SM00431
Domain	SCAN_BOX	ZNF449 ZSCAN22 ZSCAN9	4.73e-04	58	49	3	PS50804
Domain	SCAN	ZNF449 ZSCAN22 ZSCAN9	4.73e-04	58	49	3	PF02023
Domain	SCAN_dom	ZNF449 ZSCAN22 ZSCAN9	4.73e-04	58	49	3	IPR003309
Domain	Retrov_capsid_C	ZNF449 ZSCAN22 ZSCAN9	4.98e-04	59	49	3	IPR008916
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF17 ZNF668 ZNF776 ZFP90 ZNF354A ZNF493 ZNF530 GLI3 ZNF655 ZFP30 ZNF485 ZNF267 ZNF521 ZNF761 ZNF772 ZNF699 ZNF285 FAS ZNF25 ZNF354B	2.29e-12	1387	34	20	M734
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF845 ZFP90 ZNF354A ZNF493 ZNF655 ZFP30 ZNF267 ZNF699 ZNF25 ZNF354B	8.62e-06	768	34	10	MM14851
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ZNF845 ZFP90 ZNF354A ZNF493 ZNF655 ZFP30 ZNF267 ZNF699 ZNF25 ZNF354B	1.01e-04	1022	34	10	MM15436
Pathway	REACTOME_GLI_PROTEINS_BIND_PROMOTERS_OF_HH_RESPONSIVE_GENES_TO_PROMOTE_TRANSCRIPTION	GLI1 GLI3	1.18e-04	7	34	2	M27501
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY	GLI1 GLI3	5.05e-04	14	34	2	M47414
Pathway	BIOCARTA_SHH_PATHWAY	GLI1 GLI3	5.81e-04	15	34	2	MM1498
Pathway	WP_HEDGEHOG_SIGNALING_WP47	GLI1 GLI3	6.63e-04	16	34	2	M39675
Pathway	BIOCARTA_SHH_PATHWAY	GLI1 GLI3	6.63e-04	16	34	2	M11792
Pathway	WP_HEDGEHOG_SIGNALING_PATHWAY	GLI1 GLI3	1.27e-03	22	34	2	MM15924
Pathway	REACTOME_RUNX2_REGULATES_OSTEOBLAST_DIFFERENTIATION	GLI3 ZNF521	1.51e-03	24	34	2	M27803
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY	GLI1 GLI3	2.20e-03	29	34	2	M47372
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY	GLI1 GLI3	2.20e-03	29	34	2	M47377
Pathway	WP_TUMOR_SUPPRESSOR_ACTIVITY_OF_SMARCB1	GLI1 GLI3	2.51e-03	31	34	2	M39522
Pathway	REACTOME_RUNX2_REGULATES_BONE_DEVELOPMENT	GLI3 ZNF521	2.51e-03	31	34	2	M27805
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF17 ZNF845 ZNF776 ZNF354A ZNF493 ZNF655 ZNF485 ZNF267 ZNF699 ZNF25 ZNF354B	2.22e-15	181	51	11	37372979
Pubmed	The GLI-Kruppel family of human genes.	ZSCAN22 GLI1 GLI3	1.04e-07	7	51	3	2850480
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZNF462 ZFP90 KLF6 GLI1 GLI3 ZNF521 E4F1 ZNF25 SNAI3	8.19e-07	709	51	9	22988430
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	GLIPR1 ZNF462 ZNF668 ZNF845 ZFP90 MICAL2 GLI3 ZNF655 ZNF485 ZFP62 ZNF646	1.08e-06	1203	51	11	29180619
Pubmed	Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3.	GLI1 GLI3	2.11e-06	2	51	2	18559511
Pubmed	Molecular cloning and expression pattern of a Cubitus interruptus homologue from the mulberry silkworm Bombyx mori.	GLI1 GLI3	2.11e-06	2	51	2	12351188
Pubmed	A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome.	GLI1 GLI3	2.11e-06	2	51	2	21921029
Pubmed	Expression of the GLI family genes is associated with tumor progression in advanced lung adenocarcinoma.	GLI1 GLI3	2.11e-06	2	51	2	25103784
Pubmed	Palmar and plantar pads and flexion creases of genetic polydactyly mice (Pdn).	GLI1 GLI3	2.11e-06	2	51	2	9918099
Pubmed	Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves.	GLI1 GLI3	2.11e-06	2	51	2	32114096
Pubmed	Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.	GLI1 GLI3	2.11e-06	2	51	2	10693759
Pubmed	Genetic variations regulate alternative splicing in the 5' untranslated regions of the mouse glioma-associated oncogene 1, Gli1.	GLIPR1 GLI1	2.11e-06	2	51	2	20433698
Pubmed	Characterization of the mouse Kid1 gene and identification of a highly related gene, Kid2.	ZNF354A ZNF354B	2.11e-06	2	51	2	10564808
Pubmed	Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein.	ZNF423 ZNF521	2.11e-06	2	51	2	12393497
Pubmed	gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development.	GLI1 GLI3	2.11e-06	2	51	2	8364225
Pubmed	Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.	GLI1 GLI3	6.32e-06	3	51	2	24311597
Pubmed	Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes.	GLI1 GLI3	6.32e-06	3	51	2	26010061
Pubmed	Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3.	GLI1 GLI3	6.32e-06	3	51	2	10075717
Pubmed	Direct transcriptional repression of Zfp423 by Zfp521 mediates a bone morphogenic protein-dependent osteoblast versus adipocyte lineage commitment switch.	ZNF423 ZNF521	6.32e-06	3	51	2	24891617
Pubmed	A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.	GLI1 GLI3	6.32e-06	3	51	2	8387379
Pubmed	ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies.	ZNF423 ZNF521	6.32e-06	3	51	2	26788497
Pubmed	Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.	GLI1 GLI3	6.32e-06	3	51	2	16571352
Pubmed	The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway.	GLI1 GLI3	6.32e-06	3	51	2	29722127
Pubmed	Different expression patterns of Gli1-3 in mouse embryonic maxillofacial development.	GLI1 GLI3	6.32e-06	3	51	2	22178118
Pubmed	Brachyphalangy, an allele of extra-toes in the mouse.	GLI1 GLI3	6.32e-06	3	51	2	5806166
Pubmed	Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.	GLI1 GLI3	6.32e-06	3	51	2	28965847
Pubmed	Gli family members are differentially expressed during the mitotic phase of spermatogenesis.	GLI1 GLI3	6.32e-06	3	51	2	9178901
Pubmed	Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.	GLI1 GLI3	6.32e-06	3	51	2	8378770
Pubmed	Cloning and sequencing of the mouse Gli2 gene: localization to the Dominant hemimelia critical region.	GLI1 GLI3	1.26e-05	4	51	2	9027508
Pubmed	The stem cell-associated transcription co-factor, ZNF521, interacts with GLI1 and GLI2 and enhances the activity of the Sonic hedgehog pathway.	GLI1 ZNF521	1.26e-05	4	51	2	31558698
Pubmed	Comparative genomics identification of a novel set of temporally regulated hedgehog target genes in the retina.	GLI1 GLI3	1.26e-05	4	51	2	22281533
Pubmed	Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.	GLI1 GLI3	1.26e-05	4	51	2	9006072
Pubmed	Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.	GLI1 GLI3	1.26e-05	4	51	2	27793025
Pubmed	Expression profile of Gli family members and Shh in normal and mutant mouse limb development.	GLI1 GLI3	1.26e-05	4	51	2	9438426
Pubmed	Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development.	GLI1 GLI3	1.26e-05	4	51	2	8150204
Pubmed	Anorectal malformations caused by defects in sonic hedgehog signaling.	GLI1 GLI3	1.26e-05	4	51	2	11485934
Pubmed	Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1.	GLI1 GLI3	1.26e-05	4	51	2	10531011
Pubmed	SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors.	GLI1 GLI3	2.10e-05	5	51	2	20711444
Pubmed	Functional compensation in Hedgehog signaling during mouse prostate development.	GLI1 GLI3	2.10e-05	5	51	2	16707121
Pubmed	Genomic organization, chromosomal assignment, and expression analysis of the mouse suppressor of fused gene (Sufu) coding a Gli protein partner.	GLI1 GLI3	2.10e-05	5	51	2	10920228
Pubmed	A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro.	GLI1 GLI3	2.10e-05	5	51	2	9118802
Pubmed	Evidence for the involvement of the Gli gene family in embryonic mouse lung development.	GLI1 GLI3	2.10e-05	5	51	2	9268579
Pubmed	Sonic hedgehog signals to multiple prostate stromal stem cells that replenish distinct stromal subtypes during regeneration.	GLI1 GLI3	2.10e-05	5	51	2	24218555
Pubmed	Gli regulation by the opposing activities of fused and suppressor of fused.	GLI1 GLI3	2.10e-05	5	51	2	10806483
Pubmed	p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9.	GLI1 GLI3	2.10e-05	5	51	2	26282181
Pubmed	Gli1 is a target of Sonic hedgehog that induces ventral neural tube development.	GLI1 GLI3	2.10e-05	5	51	2	9216996
Pubmed	Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain.	GLI1 GLI3	2.10e-05	5	51	2	15614767
Pubmed	Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3.	GLI1 GLI3	2.10e-05	5	51	2	19996099
Pubmed	Expression of sonic hedgehog, patched, and Gli1 in developing taste papillae of the mouse.	GLI1 GLI3	2.10e-05	5	51	2	10096602
Pubmed	Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation.	GLI1 GLI3	2.10e-05	5	51	2	16611981
Pubmed	Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning.	GLI1 GLI3	2.10e-05	5	51	2	15315762
Pubmed	A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud.	GLI1 GLI3	2.10e-05	5	51	2	24700818
Pubmed	Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli.	GLI1 GLI3	2.10e-05	5	51	2	10564661
Pubmed	Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.	ZNF423 ZNF521	2.10e-05	5	51	2	14630787
Pubmed	Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma.	GLI1 GLI3	2.10e-05	5	51	2	19593328
Pubmed	Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling.	GLI1 GLI3	2.10e-05	5	51	2	26120032
Pubmed	Expression pattern of Irx1 and Irx2 during mouse digit development.	GLI1 GLI3	2.10e-05	5	51	2	11472848
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF462 ZNF668 KLF6 GLI3 ZNF423 ZNF655 ZNF25 ZNF646	2.16e-05	808	51	8	20412781
Pubmed	Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells.	GLI1 GLI3	3.15e-05	6	51	2	21549329
Pubmed	Pleiotropy in FOXC1-attributable phenotypes involves altered ciliation and cilia-dependent signaling.	GLI1 GLI3	3.15e-05	6	51	2	39217245
Pubmed	RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6.	GLI1 GLI3	3.15e-05	6	51	2	33895473
Pubmed	Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.	GLI1 GLI3	3.15e-05	6	51	2	14681189
Pubmed	Targeted disruption of Sonic Hedgehog in the mouse adrenal leads to adrenocortical hypoplasia.	GLI1 GLI3	3.15e-05	6	51	2	19536807
Pubmed	A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development.	GLI1 GLI3	3.15e-05	6	51	2	12385751
Pubmed	Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling.	GLI1 GLI3	3.15e-05	6	51	2	31279575
Pubmed	Physical and functional interactions between Zic and Gli proteins.	GLI1 GLI3	3.15e-05	6	51	2	11238441
Pubmed	Expression of sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium.	GLI1 GLI3	3.15e-05	6	51	2	19432668
Pubmed	Titration of GLI3 repressor activity by sonic hedgehog signaling is critical for maintaining multiple adult neural stem cell and astrocyte functions.	GLI1 GLI3	3.15e-05	6	51	2	24174682
Pubmed	Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling.	GLI1 GLI3	3.15e-05	6	51	2	34423857
Pubmed	The Pluripotency Factor NANOG Binds to GLI Proteins and Represses Hedgehog-mediated Transcription.	GLI1 GLI3	3.15e-05	6	51	2	26797124
Pubmed	Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling.	GLI1 GLI3	3.15e-05	6	51	2	17202190
Pubmed	Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.	GLI1 GLI3	3.15e-05	6	51	2	16254602
Pubmed	Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium.	GLI1 GLI3	3.15e-05	6	51	2	21209912
Pubmed	Genetic analysis of Hedgehog signaling in ventral body wall development and the onset of omphalocele formation.	GLI1 GLI3	3.15e-05	6	51	2	21283718
Pubmed	Irx1 and Irx2 expression in early lung development.	GLI1 GLI3	3.15e-05	6	51	2	11472847
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ZNF137P ZBTB39 ZNF354A GLI1 GLI3 ZFP30 ZSCAN9 E4F1	3.86e-05	877	51	8	20211142
Pubmed	Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice.	GLI1 GLI3	4.41e-05	7	51	2	9152005
Pubmed	A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus.	GLI1 GLI3	4.41e-05	7	51	2	21653639
Pubmed	Analysis of the Sonic Hedgehog signaling pathway in normal and abnormal bladder development.	GLI1 GLI3	4.41e-05	7	51	2	23308271
Pubmed	Sonic hedgehog regulates discrete populations of astrocytes in the adult mouse forebrain.	GLI1 GLI3	4.41e-05	7	51	2	20943901
Pubmed	Hedgehog regulates Norrie disease protein to drive neural progenitor self-renewal.	GLI1 GLI3	4.41e-05	7	51	2	23201751
Pubmed	FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine.	GLI1 GLI3	4.41e-05	7	51	2	19049965
Pubmed	TMEM216 promotes primary ciliogenesis and Hedgehog signaling through the SUFU-GLI2/GLI3 axis.	GLI1 GLI3	4.41e-05	7	51	2	38261656
Pubmed	Differential activities of Sonic hedgehog mediated by Gli transcription factors define distinct neuronal subtypes in the dorsal thalamus.	GLI1 GLI3	4.41e-05	7	51	2	14568100
Pubmed	Expression patterns of key Sonic Hedgehog signaling pathway components in the developing and adult mouse midbrain and in the MN9D cell line.	GLI1 GLI3	4.41e-05	7	51	2	28799057
Pubmed	Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus.	GLI1 GLI3	4.41e-05	7	51	2	9731531
Pubmed	Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3.	GLI1 GLI3	4.41e-05	7	51	2	12435627
Pubmed	Gli3-mediated repression of Hedgehog targets is required for normal mammary development.	GLI1 GLI3	4.41e-05	7	51	2	16914490
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF493 ZNF25 ZFP62	5.22e-05	49	51	3	9630514
Pubmed	Morphogenesis.	GLI1 GLI3	5.87e-05	8	51	2	9988217
Pubmed	Cell cycle regulator E2F4 is essential for the development of the ventral telencephalon.	GLI1 GLI3	5.87e-05	8	51	2	17537963
Pubmed	A primary cilia-dependent etiology for midline facial disorders.	GLI1 GLI3	5.87e-05	8	51	2	20106874
Pubmed	Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1.	GLI1 GLI3	5.87e-05	8	51	2	10529434
Pubmed	Gli1 is not required for Pdgfralpha expression during mouse embryonic development.	GLI1 GLI3	5.87e-05	8	51	2	15811134
Pubmed	GLI transcriptional repression is inert prior to Hedgehog pathway activation.	GLI1 GLI3	5.87e-05	8	51	2	35145123
Pubmed	A hypermorphic mouse Gli3 allele results in a polydactylous limb phenotype.	GLI1 GLI3	5.87e-05	8	51	2	17266131
Pubmed	Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity.	GLI1 GLI3	5.87e-05	8	51	2	10631181
Pubmed	Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates.	GLI1 GLI3	5.87e-05	8	51	2	34610275
Pubmed	Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex.	GLI1 GLI3	5.87e-05	8	51	2	11960000
Pubmed	Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube.	GLI1 GLI3	5.87e-05	8	51	2	22265416
Interaction	ZNF423 interactions	ZNF17 GLI1 GLI3 ZNF423 ZNF521 ZFP62	2.90e-08	73	51	6	int:ZNF423
Interaction	TRIM28 interactions	ZNF462 ZNF17 ZNF845 ZNF776 ZFP90 ZNF354A ZNF493 ZNF655 ZFP30 ZNF485 ZNF267 ZNF888 ZNF761 ZNF699 ZNF25 ZNF354B	3.81e-07	1474	51	16	int:TRIM28
Interaction	ZNF521 interactions	ZNF17 GLI1 ZNF423 ZNF521	3.44e-06	41	51	4	int:ZNF521
Interaction	ZFP62 interactions	ZNF668 GLI1 GLI3 ZNF423 ZFP62	5.07e-06	99	51	5	int:ZFP62
Interaction	GLI2 interactions	GLI1 GLI3 ZNF423 ZNF521 ZFP62	5.07e-06	99	51	5	int:GLI2
Interaction	ZNF467 interactions	ZNF668 ZNF845 ZNF354A ZFP30 ZNF761 ZFP62	5.84e-06	179	51	6	int:ZNF467
Interaction	ZFP37 interactions	GLI1 GLI3 ZNF423 ZFP62	7.09e-06	49	51	4	int:ZFP37
Interaction	ZNF667 interactions	GLI1 GLI3 ZNF423 ZFP62	9.72e-06	53	51	4	int:ZNF667
Interaction	ZNF287 interactions	GLI1 GLI3 ZNF423 ZFP62	1.60e-05	60	51	4	int:ZNF287
Interaction	ZNF710 interactions	GLI1 ZNF423 ZFP62	5.91e-05	30	51	3	int:ZNF710
Interaction	ZFP3 interactions	GLI3 ZNF423 ZFP62	5.91e-05	30	51	3	int:ZFP3
Interaction	MYNN interactions	GLI1 ZNF423 ZFP62	7.19e-05	32	51	3	int:MYNN
Interaction	ZNF382 interactions	GLI3 ZNF423 ZFP62	7.90e-05	33	51	3	int:ZNF382
Interaction	ZNF513 interactions	GLI3 ZNF423 ZFP62	8.64e-05	34	51	3	int:ZNF513
Interaction	ZSCAN22 interactions	ZNF449 ZSCAN22 ZSCAN9	8.64e-05	34	51	3	int:ZSCAN22
Interaction	ZNF652 interactions	GLI3 ZNF423 ZFP62	9.44e-05	35	51	3	int:ZNF652
Interaction	ZNF17 interactions	ZNF17 ZNF423 ZNF521	1.12e-04	37	51	3	int:ZNF17
Interaction	ZFP28 interactions	GLI3 ZNF423 ZFP62	1.12e-04	37	51	3	int:ZFP28
Interaction	GZF1 interactions	GLI3 ZNF423 E4F1 ZFP62	1.34e-04	103	51	4	int:GZF1
Interaction	RNF4 interactions	GLIPR1 ZNF462 GMCL1 ZNF668 ZNF845 ZFP90 MICAL2 GLI3 ZNF655 ZNF485 ZFP62 ZNF646	1.64e-04	1412	51	12	int:RNF4
Interaction	ZSCAN21 interactions	ZSCAN22 GLI3 ZNF423 ZFP62	3.08e-04	128	51	4	int:ZSCAN21
Interaction	ZNF449 interactions	ZNF449 ZSCAN22	3.40e-04	11	51	2	int:ZNF449
Interaction	ZNF473 interactions	GLI3 ZNF423 ZFP62	3.85e-04	56	51	3	int:ZNF473
Interaction	ZBTB47 interactions	ZNF668 ZFP62 PNMA3 ZNF646	4.81e-04	144	51	4	int:ZBTB47
Interaction	CTCFL interactions	GLI3 ZNF423 ZFP62	5.20e-04	62	51	3	int:CTCFL
Interaction	ZNF787 interactions	GLI3 ZNF423 ZFP62	5.71e-04	64	51	3	int:ZNF787
Interaction	XAGE2 interactions	ZNF462 GMCL1	6.46e-04	15	51	2	int:XAGE2
Interaction	NOTCH2 interactions	ZNF668 ZBTB39 ZNF888 ZNF761 E4F1 ZNF646	6.69e-04	423	51	6	int:NOTCH2
Interaction	GLI1 interactions	GLI1 ZNF423 ZNF521 ZFP62	6.99e-04	159	51	4	int:GLI1
Interaction	ZNF8 interactions	GLI1 ZNF423 ZFP62	7.42e-04	70	51	3	int:ZNF8
Interaction	SCAND1 interactions	ZNF449 ZSCAN22 ZSCAN9	7.42e-04	70	51	3	int:SCAND1
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF17 ZNF134 ZNF137P ZNF845 ZNF776 ZNF530 ZSCAN22 ZFP30 ZNF888 ZNF761 ZNF772 ZNF285	5.55e-09	1192	51	12	chr19q13
Cytoband	19q13.43	ZNF776 ZNF530 ZSCAN22 ZNF772	2.81e-06	87	51	4	19q13.43
Cytoband	16p11.2	ZNF668 HIRIP3 ZNF267 ZNF646	6.23e-05	191	51	4	16p11.2
Cytoband	19q13.4	ZNF17 ZNF134 ZNF137P	9.62e-05	79	51	3	19q13.4
Cytoband	5q35.3	ZNF354A ZNF354B ZFP62	1.66e-04	95	51	3	5q35.3
Cytoband	Ensembl 112 genes in cytogenetic band chr16p11	ZNF668 HIRIP3 ZNF267 ZNF646	2.63e-04	278	51	4	chr16p11
Cytoband	Ensembl 112 genes in cytogenetic band chr5q35	ZNF354A ZNF354B ZFP62	2.30e-03	235	51	3	chr5q35
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF449 ZNF462 ZNF17 ZNF134 ZNF668 ZNF845 ZNF776 ZFP90 ZBTB39 ZNF354A ZNF493 ZNF530 ZSCAN22 KLF6 GLI1 GLI3 ZNF423 ZNF655 ZFP30 ZSCAN9 ZNF485 ZNF267 ZNF521 ZNF888 ZNF761 E4F1 ZNF772 ZNF699 ZNF285 ZNF25 ZNF354B SNAI3 ZNF491 ZFP62 ZNF646	8.95e-41	718	45	35	28
ToppCell	10x5'-Lung-Lymphocytic_T_CD4/8-lo-Trm_Tgd\|Lung / Manually curated celltypes from each tissue	GMCL1 ZNF776 ZNF530 ZSCAN9 ZNF888 ZNF354B	3.75e-08	167	51	6	dcbcc658082910838c8082d71a64917055086cc4
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ZNF462 ZNF17 ZNF530 METTL25 ZNF354B	1.32e-06	166	51	5	8d5d09f25e8903d481c2097fed435e69d42ccdb5
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GLIPR1 GLI3 ZNF354B ZNF491 PNMA3	2.07e-06	182	51	5	52274af3136d4fd4a495f5882618444661421f0f
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GLIPR1 GLI3 ZNF354B ZNF491 PNMA3	2.07e-06	182	51	5	dfde2d9950f445c6c936ac828f7210de87bb45ec
Disease	primary bacterial infectious disease (implicated_via_orthology)	GLI1 GLI3	7.77e-05	9	44	2	DOID:0050338 (implicated_via_orthology)
Disease	ocular hypertension (biomarker_via_orthology)	GLI1 FAS	2.91e-04	17	44	2	DOID:9282 (biomarker_via_orthology)
Disease	pre-malignant neoplasm (biomarker_via_orthology)	GLI1 GLI3	2.91e-04	17	44	2	DOID:0060071 (biomarker_via_orthology)
Disease	Cannabis use, age at onset	ZNF423 SLC28A3	3.66e-04	19	44	2	EFO_0004847, EFO_0007585
Disease	seminoma (is_marker_for)	ZNF354A FAS	4.93e-04	22	44	2	DOID:4440 (is_marker_for)
Disease	obsolete aging, epigenetic status	MICA ZNF25	2.16e-03	46	44	2	EFO_0000473, GO_0007568
Disease	atrial fibrillation	ZNF462 GMCL1 PAPPA E4F1	2.24e-03	371	44	4	EFO_0000275
Disease	Gastrointestinal Stromal Sarcoma	GLI1 GLI3	2.25e-03	47	44	2	C3179349
Disease	multiple sclerosis (is_marker_for)	GLI1 FAS	2.44e-03	49	44	2	DOID:2377 (is_marker_for)
Disease	body weight	ZNF423 ZNF521 PAPPA SLC28A3 MICA E4F1 FAS	2.45e-03	1261	44	7	EFO_0004338
Disease	Gastrointestinal Stromal Tumors	GLI1 GLI3	2.54e-03	50	44	2	C0238198
Disease	interleukin 12 measurement	ZNF462 ZNF521	2.85e-03	53	44	2	EFO_0004753
Disease	susceptibility to common cold measurement	ZNF423 MICA	2.96e-03	54	44	2	EFO_0008417
Disease	Diffuse Large B-Cell Lymphoma	GLI1 FAS	3.07e-03	55	44	2	C0079744
Disease	migraine disorder, type 2 diabetes mellitus	GLI3 SLC28A3	3.64e-03	60	44	2	MONDO_0005148, MONDO_0005277
Disease	mosquito bite reaction size measurement	ZNF423 MICA FAS	3.90e-03	212	44	3	EFO_0008378

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLSSCCEYKHRKGSR	ERICH3	361	Q5RHP9
KRKRSSGSFCYCHPD	GMCL1	51	Q96IK5
FYVRCCKKKTSAAEG	MICA	326	Q29983
FKTRICKKVCGHYTQ	GLIPR1	126	P48060
HKCTFEGCTKAYSRL	GLI3	546	P10071
NYKKLLGSCCSHKER	HIRIP3	441	Q9BW71
TKCDRHVGKIYSKCS	METTL25	491	Q8N6Q8
HKCTFEGCRKSYSRL	GLI1	301	P08151
RCRENKHKVGSFCKY	PAPPA	1361	Q13219
LICKKRHCGYSKAFQ	EPHA8	561	P29322
RYVCALCHKTFKTGS	E4F1	191	Q66K89
DYSCTHSKGKRDRKK	CCDC168	6961	Q8NDH2
KRGSHKEYKRGKSCT	MICAL2	71	O94851
CHVLKKKGYRCRTSR	RELL2	36	Q8NC24
RKRKRHTFCYSCGED	PNMA3	406	Q9UL41
RYDTVCGFCRKHKTT	SLC28A3	86	Q9HAS3
DAKKYRCRRCTKTFS	SNAI3	261	Q3KNW1
EKHYKCSECGKTFSR	ZNF845	296	Q96IR2
ECGKTFSRKSYFICH	ZNF761	666	Q86XN6
RIHTSDKLYECKKCG	ZFP30	206	Q9Y2G7
KRSGRRYKCVSCTKT	ZNF668	16	Q96K58
YTDKAHFSSKCRRCR	FAS	91	P25445
KECGKAFRCSSYLTK	ZNF267	411	Q14586
FKCTYCSRLFKHKRS	ZNF521	146	Q96K83
KCNKCGKIFRHRSYL	ZNF137P	101	P52743
ERRYKCSQCGKTYKH	ZNF646	236	O15015
KVCHKFFRGRSTIKC	ZBTB39	636	O15060
TYSGKRSSKCRECRK	ZSCAN22	261	P10073
YKCKECDKVFSRKSH	ZNF888	466	P0CJ79
IHTRAKSYKCSSCER	ZNF655	296	Q8N720
YKCKECGKFFSRNSH	ZNF25	286	P17030
YKCEECGKAFKRSSH	ZNF493	501	Q6ZR52
HKCDECGKSFKYNSR	ZFP62	141	Q8NB50
CGKAFIRSSYCRKHE	ZNF491	416	Q8N8L2
HKPFRCKLCSFKSSY	ZNF462	2051	Q96JM2
FSKAGQKKHALRCYC	TRAPPC8	571	Q9Y2L5
YECSVCGKSFIRKTH	ZNF530	491	Q6P9A1
FKCTYCSRLFKHKRS	ZNF423	166	Q2M1K9
IQKRYHCKECGKVFS	ZSCAN9	306	O15535
THTVEKSYRCKECGK	ZNF354A	291	O60765
KSYRCKECGKSFSRR	ZNF354A	296	O60765
THTVEKCYRCKECGK	ZNF354B	291	Q96LW1
KCYRCKECGKSFSRR	ZNF354B	296	Q96LW1
CKECGKAFRHSSYLT	ZNF699	561	Q32M78
YRCIECGKFLKKHST	ZNF485	186	Q8NCK3
YKCSECGKTFSRKDS	ZNF772	266	Q68DY9
YKCKECGKGFRRSSS	ZNF285	316	Q96NJ3
YKCSECGKAFSRKDT	ZNF134	176	P52741
HTRERTYKCSKCGKF	ZNF17	576	P17021
YKCTHCSKSFRQRAG	ZNF449	491	Q6P9G9
YKCDKCRKAFIHRSS	ZFP90	211	Q8TF47
CKECRKSFRYKSHLT	ZNF776	406	Q68DI1
RCHFNGCRKVYTKSS	KLF6	201	Q99612