Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionintracellularly cAMP-activated cation channel activity

HCN2 HCN4 HCN1

8.85e-0710403GO:0005222
GeneOntologyMolecularFunctioncyclic nucleotide binding

PDE5A HCN2 HCN4 HCN1

1.08e-0639404GO:0030551
GeneOntologyMolecularFunctionintracellularly cyclic nucleotide-activated monoatomic cation channel activity

HCN2 HCN4 HCN1

2.10e-0613403GO:0005221
GeneOntologyMolecularFunctioncyclic nucleotide-activated monoatomic ion channel activity

HCN2 HCN4 HCN1

2.10e-0613403GO:0043855
GeneOntologyMolecularFunctioncAMP binding

HCN2 HCN4 HCN1

1.66e-0525403GO:0030552
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

HCN2 HCN4 HCN1

1.88e-0526403GO:0005248
GeneOntologyMolecularFunctionN-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

CHSY1 CHSY3

2.34e-054402GO:0050510
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

HCN2 HCN4 HCN1

3.90e-0533403GO:0005217
GeneOntologyMolecularFunctionglucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

CHSY1 CHSY3

5.84e-056402GO:0047238
GeneOntologyMolecularFunctionsodium channel activity

HCN2 HCN4 HCN1

1.54e-0452403GO:0005272
GeneOntologyMolecularFunctionUDP-glycosyltransferase activity

CHSY1 CHSY3 MGAT5B UGGT1

2.44e-04153404GO:0008194
GeneOntologyMolecularFunctionhexosyltransferase activity

CHSY1 CHSY3 MGAT5B UGGT1

8.22e-04211404GO:0016758
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

HCN2 HCN4 HCN1

1.11e-03102403GO:0005249
GeneOntologyMolecularFunctionpotassium channel activity

HCN2 HCN4 HCN1

2.14e-03128403GO:0005267
GeneOntologyMolecularFunctionacetylgalactosaminyltransferase activity

CHSY1 CHSY3

2.23e-0335402GO:0008376
GeneOntologyMolecularFunctionglucuronosyltransferase activity

CHSY1 CHSY3

2.23e-0335402GO:0015020
GeneOntologyMolecularFunctionglycosyltransferase activity

CHSY1 CHSY3 MGAT5B UGGT1

2.57e-03288404GO:0016757
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

HCN2 HCN4 HCN1

2.76e-03140403GO:0099094
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

HCN2 HCN4 HCN1

3.48e-03152403GO:0022843
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

HCN2 HCN4 HCN1

4.52e-03167403GO:0015079
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CUL5 HCN2 HCN4 HCN1

4.80e-03343404GO:0005261
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

HCN2 HCN4 HCN1

4.83e-03171403GO:0015081
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

HCN2 HCN4 HCN1

5.74e-03182403GO:0005244
GeneOntologyMolecularFunctionprotein serine kinase activity

CAMKK2 CIT NEK9 MYO3B

5.86e-03363404GO:0106310
GeneOntologyMolecularFunctionvoltage-gated channel activity

HCN2 HCN4 HCN1

5.92e-03184403GO:0022832
GeneOntologyMolecularFunctionprotein kinase A binding

ARFGEF1 AKAP4

6.03e-0358402GO:0051018
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

HCN2 HCN4 HCN1

6.75e-03193403GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

HCN2 HCN4 HCN1

7.15e-03197403GO:0022834
GeneOntologyCellularComponentHCN channel complex

HCN2 HCN4 HCN1

2.59e-084403GO:0098855
GeneOntologyCellularComponentvoltage-gated potassium channel complex

HCN2 HCN4 HCN1

7.02e-0491403GO:0008076
GeneOntologyCellularComponentmidbody

TTC28 BIRC6 CIT CRMP1

8.38e-04222404GO:0030496
GeneOntologyCellularComponentpotassium channel complex

HCN2 HCN4 HCN1

1.03e-03104403GO:0034705
MousePhenosmall olfactory bulb

KIFBP CHD7 HCN4 CIT

1.24e-0553384MP:0002741
DomainIon_trans_N

HCN2 HCN4 HCN1

3.63e-084403PF08412
DomainIon_trans_N

HCN2 HCN4 HCN1

3.63e-084403IPR013621
DomainK_chnl_volt-dep_EAG/ELK/ERG

HCN2 HCN4 HCN1

3.26e-0614403IPR003938
DomaincNMP-bd_CS

HCN2 HCN4 HCN1

5.00e-0616403IPR018488
DomainCNMP_BINDING_1

HCN2 HCN4 HCN1

4.32e-0532403PS00888
DomainCNMP_BINDING_2

HCN2 HCN4 HCN1

4.32e-0532403PS00889
DomaincNMP

HCN2 HCN4 HCN1

5.20e-0534403SM00100
DomaincNMP_binding

HCN2 HCN4 HCN1

5.20e-0534403PF00027
DomaincNMP-bd_dom

HCN2 HCN4 HCN1

5.68e-0535403IPR000595
DomainCNMP_BINDING_3

HCN2 HCN4 HCN1

5.68e-0535403PS50042
DomaincNMP-bd-like

HCN2 HCN4 HCN1

7.29e-0538403IPR018490
Domain-

VPS11 KIFBP APPBP2 TTC28 CTR9

7.65e-052074051.25.40.10
DomainChond_GalNAc

CHSY1 CHSY3

1.24e-048402IPR008428
DomainCHGN

CHSY1 CHSY3

1.24e-048402PF05679
DomainTPR-like_helical_dom

VPS11 KIFBP APPBP2 TTC28 CTR9

1.33e-04233405IPR011990
Domain-

HCN2 HCN4 HCN1

1.47e-04484032.60.120.10
DomainRmlC-like_jellyroll

HCN2 HCN4 HCN1

1.76e-0451403IPR014710
Domain-

CHSY1 CHSY3 UGGT1

6.92e-04814033.90.550.10
DomainNucleotide-diphossugar_trans

CHSY1 CHSY3 UGGT1

8.80e-0488403IPR029044
DomainIon_trans_dom

HCN2 HCN4 HCN1

1.86e-03114403IPR005821
DomainIon_trans

HCN2 HCN4 HCN1

1.86e-03114403PF00520
DomainTPR

APPBP2 TTC28 CTR9

2.64e-03129403SM00028
DomainTPR_repeat

APPBP2 TTC28 CTR9

2.88e-03133403IPR019734
DomainTPR-contain_dom

APPBP2 TTC28 CTR9

4.04e-03150403IPR013026
DomainER_TARGET

RCN2 UGGT1

4.55e-0347402PS00014
DomainTPR_2

TTC28 CTR9

5.13e-0350402PF07719
DomainTPR_2

TTC28 CTR9

5.13e-0350402IPR013105
DomainTPR

APPBP2 TTC28 CTR9

5.26e-03165403PS50005
DomainTPR_REGION

APPBP2 TTC28 CTR9

5.26e-03165403PS50293
DomainTPR_8

TTC28 CTR9

5.75e-0353402PF13181
DomainSer/Thr_kinase_AS

CAMKK2 CIT NEK9 MYO3B

6.97e-03357404IPR008271
DomainS_TKc

CAMKK2 CIT NEK9 MYO3B

7.11e-03359404SM00220
DomainPROTEIN_KINASE_ST

CAMKK2 CIT NEK9 MYO3B

7.32e-03362404PS00108
DomainPkinase

CAMKK2 CIT NEK9 MYO3B

8.73e-03381404PF00069
PathwayKEGG_MEDICUS_REFERENCE_CHONDROITIN_SULFATE_BIOSYNTHESIS

CHSY1 CHSY3

1.57e-048342M47920
PathwayWP_PTF1A_RELATED_REGULATORY_PATHWAY

PDX1 PROX1

3.06e-0411342M39548
PathwayWP_PTF1A_RELATED_REGULATORY_PATHWAY

PDX1 PROX1

4.33e-0413342MM15904
PathwayKEGG_MEDICUS_REFERENCE_AUTOPHAGOSOME_AND_LYSOSOME_FUSION_TETHERING_FACTOR

VPS11 BIRC6

6.63e-0416342M47978
PathwayWP_GENES_TARGETED_BY_MIRNAS_IN_ADIPOCYTES

HCN2 HCN4

8.43e-0418342M39405
PathwayREACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS

CHSY1 CHSY3

9.41e-0419342MM14800
PathwayREACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS

CHSY1 CHSY3

1.04e-0320342M658
PathwayKEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE

CHSY1 CHSY3

1.27e-0322342M19166
PathwayREACTOME_POTASSIUM_CHANNELS

HCN2 HCN4 HCN1

1.67e-0398343MM14545
PathwayREACTOME_POTASSIUM_CHANNELS

HCN2 HCN4 HCN1

1.92e-03103343M1073
Pubmed

HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.

HCN2 HCN4 HCN1

1.41e-09340333181864
Pubmed

Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.

HCN2 HCN4 HCN1

1.41e-09340322652004
Pubmed

Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.

HCN2 HCN4 HCN1

1.41e-09340321187420
Pubmed

Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.

HCN2 HCN4 HCN1

1.41e-09340321945247
Pubmed

Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.

HCN2 HCN4 HCN1

1.41e-09340322006928
Pubmed

Functional expression of the human HCN3 channel.

HCN2 HCN4 HCN1

5.63e-09440316043489
Pubmed

Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.

HCN2 HCN4 HCN1

5.63e-09440322748890
Pubmed

Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.

HCN2 HCN4 HCN1

5.63e-0944039630217
Pubmed

Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.

HCN2 HCN4 HCN1

5.63e-0944039405696
Pubmed

Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.

HCN2 HCN4 HCN1

5.63e-09440312928435
Pubmed

Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.

HCN2 HCN4 HCN1

5.63e-09440321615589
Pubmed

Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.

HCN2 HCN4 HCN1

5.63e-09440320140458
Pubmed

Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.

HCN2 HCN4 HCN1

1.41e-08540334429357
Pubmed

Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.

HCN2 HCN4 HCN1

1.41e-08540315564593
Pubmed

Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.

HCN2 HCN4 HCN1

2.81e-08640325761792
Pubmed

Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.

HCN2 HCN4 HCN1

4.92e-08740319421833
Pubmed

International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.

HCN2 HCN4 HCN1

1.68e-071040316382102
Pubmed

Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart.

HCN2 HCN4 HCN1

3.08e-071240317482496
Pubmed

Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.

HCN2 HCN4 HCN1

5.08e-071440329107716
Pubmed

Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation.

HCN2 HCN4 HCN1

6.35e-071540321147989
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

KIFBP CHD7 HCN2 HCN4 CIT NEK9 HCN1 CRMP1 PROX1

1.17e-0696340928671696
Pubmed

Compartmental distribution of hyperpolarization-activated cyclic-nucleotide-gated channel 2 and hyperpolarization-activated cyclic-nucleotide-gated channel 4 in thalamic reticular and thalamocortical relay neurons.

HCN2 HCN4

1.29e-06240216806719
Pubmed

Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring.

HCN2 HCN1

1.29e-06240219524546
Pubmed

An arginine residue in the pore region is a key determinant of chloride dependence in cardiac pacemaker channels.

HCN2 HCN1

1.29e-06240215644313
Pubmed

A leucine zipper motif essential for gating of hyperpolarization-activated channels.

HCN2 HCN1

1.29e-06240223048023
Pubmed

Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.

HCN2 HCN4

1.29e-06240212813043
Pubmed

The Hyperpolarization-Activated HCN4 Channel is Important for Proper Maintenance of Oscillatory Activity in the Thalamocortical System.

HCN2 HCN4

1.29e-06240230877792
Pubmed

HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons.

HCN2 HCN1

1.29e-06240215525777
Pubmed

HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.

HCN2 HCN1

1.29e-06240222948144
Pubmed

Two pacemaker channels from human heart with profoundly different activation kinetics.

HCN2 HCN4

1.29e-06240210228147
Pubmed

Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels.

HCN2 HCN1

1.29e-06240212034718
Pubmed

Functional heteromerization of HCN1 and HCN2 pacemaker channels.

HCN2 HCN1

1.29e-06240211133998
Pubmed

Chondroitin sulfate synthase-3. Molecular cloning and characterization.

CHSY1 CHSY3

1.29e-06240212907687
Pubmed

HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease.

HCN2 HCN1

1.29e-06240221076425
Pubmed

In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality.

HCN2 HCN1

1.29e-06240219171659
Pubmed

Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family.

HCN2 HCN1

1.29e-06240229980633
Pubmed

Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS).

HCN2 HCN1

1.29e-06240232543742
Pubmed

Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels.

HCN2 HCN1

1.29e-06240217261842
Pubmed

MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation.

HCN2 HCN1

1.29e-06240211420311
Pubmed

Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.

HCN4 HCN1

1.29e-06240219135060
Pubmed

Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels.

HCN2 HCN1

1.29e-06240218579800
Pubmed

Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels.

HCN2 HCN4

1.29e-06240216777944
Pubmed

Hyperpolarization-activated cation current contributes to spontaneous network activity in developing neocortical cultures.

HCN2 HCN1

1.29e-06240222094222
Pubmed

Processing of retinal signals in normal and HCN deficient mice.

HCN2 HCN1

1.29e-06240222279546
Pubmed

Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.

HCN4 HCN1

1.29e-06240217548059
Pubmed

Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels.

HCN2 HCN1

1.29e-06240212562911
Pubmed

Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells.

HCN4 HCN1

1.29e-06240221456027
Pubmed

Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias.

HCN2 HCN4

1.29e-06240215687126
Pubmed

Control of heart rate by cAMP sensitivity of HCN channels.

HCN2 HCN4

1.29e-06240219570998
Pubmed

Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli.

HCN4 HCN1

1.29e-06240211675786
Pubmed

Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy.

HCN2 HCN1

1.29e-06240217931874
Pubmed

Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons.

HCN2 HCN1

1.29e-06240224638995
Pubmed

Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus.

HCN2 HCN1

1.29e-06240212890777
Pubmed

Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells.

HCN2 HCN4

1.29e-06240212194012
Pubmed

Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels.

HCN2 HCN4

1.29e-06240219574228
Pubmed

Evolutionary emergence of N-glycosylation as a variable promoter of HCN channel surface expression.

HCN2 HCN1

1.29e-06240220130205
Pubmed

Case-control pharmacogenetic study of HCN1/HCN2 variants and genetic generalized epilepsies.

HCN2 HCN1

1.29e-06240229047147
Pubmed

HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels.

HCN2 HCN4

1.29e-06240217553794
Pubmed

Functional expression of the hyperpolarization-activated, non-selective cation current I(f) in immortalized HL-1 cardiomyocytes.

HCN2 HCN1

1.29e-06240212433951
Pubmed

Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.

HCN2 HCN4 HCN1

1.85e-062140330270038
Pubmed

EP3 activation facilitates bladder excitability via HCN channels on ICCs.

HCN4 HCN1

3.87e-06340228131828
Pubmed

Interaction of the pacemaker channel HCN1 with filamin A.

HCN2 HCN1

3.87e-06340215292205
Pubmed

KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents.

HCN2 HCN4

3.87e-06340212856183
Pubmed

Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits.

HCN2 HCN1

3.87e-06340222880098
Pubmed

Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.

CHSY1 CHSY3

3.87e-06340233089528
Pubmed

Impaired dendritic expression and plasticity of h-channels in the fmr1(-/y) mouse model of fragile X syndrome.

HCN2 HCN1

3.87e-06340222662315
Pubmed

HCN channels expressed in the inner ear are necessary for normal balance function.

HCN2 HCN1

3.87e-06340222090507
Pubmed

A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase.

HCN2 HCN4

3.87e-06340216079136
Pubmed

Transcriptional control of pacemaker channel genes HCN2 and HCN4 by Sp1 and implications in re-expression of these genes in hypertrophied myocytes.

HCN2 HCN4

3.87e-06340219471099
Pubmed

A family of hyperpolarization-activated mammalian cation channels.

HCN2 HCN1

3.87e-0634029634236
Pubmed

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.

HCN2 HCN4 HCN1

6.19e-063140317473172
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

RCN2 ARFGEF1 CHSY1 CHSY3 NEK9 LNPEP SIL1 UGGT1 LAMA1

7.05e-06120140935696571
Pubmed

Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.

HCN2 HCN1

7.73e-06440225042871
Pubmed

Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons.

HCN2 HCN1

7.73e-06440226966193
Pubmed

PDK1-AKT signaling pathway regulates the expression and function of cardiac hyperpolarization-activated cyclic nucleotide-modulated channels.

HCN2 HCN4

7.73e-06440232184125
Pubmed

Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice.

HCN2 HCN1

7.73e-06440221593326
Pubmed

Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer.

CHSY1 CHSY3

7.73e-06440221468578
Pubmed

Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development.

PDX1 PROX1

1.29e-05540215739227
Pubmed

Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons.

HCN2 HCN1

1.29e-05540230886335
Pubmed

Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.

HCN2 HCN1

1.29e-05540216177047
Pubmed

Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation.

HCN2 HCN4

1.93e-05640226005035
Pubmed

The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm.

PDX1 PROX1

1.93e-05640215381696
Pubmed

Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage.

CHSY1 CHSY3

2.70e-05740217145758
Pubmed

Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.

HCN2 HCN4

2.70e-05740227956497
Pubmed

Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm.

PDX1 PROX1

2.70e-05740212351178
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

CUL5 RCN2 KIFBP BIRC6 NEK9 LNPEP CTR9 UGGT1 CRMP1

3.24e-05145540922863883
Pubmed

Transcriptional dynamics of endodermal organ formation.

PDX1 PROX1

3.60e-05840219097184
Pubmed

CHD7 and SOX2 act in a common gene regulatory network during mammalian semicircular canal and cochlear development.

CHD7 PROX1

3.60e-05840238408234
Pubmed

Biosynthesis of chondroitin sulphate by a Golgi-apparatus-enriched preparation from cultures of mouse mastocytoma cells.

CHSY1 CHSY3

3.60e-0584026781479
Pubmed

BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain.

ARFGEF1 PROX1

5.77e-051040228414797
Pubmed

Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2.

CHSY1 CHSY3

8.45e-051240229287114
Pubmed

Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis.

CHSY1 CHSY3

8.45e-051240236047655
Pubmed

NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function.

HCN2 HCN4

8.45e-051240214633990
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

RCN2 ARFGEF1 BIRC6 MEAK7 LNPEP SIL1 UGGT1

9.54e-0595240738569033
Pubmed

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas.

PDX1 PROX1

9.98e-051340210677506
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

CHD7 TTC28 BIRC6 NEK9 PROX1

1.14e-0441840534709266
Pubmed

CCG repeats in cDNAs from human brain.

HCN2 HCN1

1.16e-04144029921901
Pubmed

Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation.

PDX1 PROX1

1.16e-041440219766716
Pubmed

Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas.

PDX1 PROX1

1.16e-041440214736744
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

CHD7 CAMKK2 TTC28 BIRC6

1.30e-0422540412168954
InteractionHCN4 interactions

HCN2 HCN4 HCN1

6.03e-079403int:HCN4
InteractionHCN2 interactions

HCN2 HCN4 HCN1

2.04e-0613403int:HCN2
InteractionRCN2 interactions

RCN2 CHSY3 BRD8 CGNL1 CIT MYO3B

1.83e-05282406int:RCN2
InteractionMYCBPAP interactions

CHSY1 CHSY3 TTC28

2.55e-0529403int:MYCBPAP
InteractionCALU interactions

RCN2 PTBP3 KIFBP CIT UGGT1 MYO3B

4.89e-05336406int:CALU
InteractionCHSY3 interactions

RCN2 CHSY1 CHSY3

4.94e-0536403int:CHSY3
InteractionVEGFD interactions

RCN2 BIRC6 SIL1

5.82e-0538403int:VEGFD
InteractionHCN1 interactions

HCN2 HCN4 CIT HCN1

6.14e-05108404int:HCN1
InteractionKCNE2 interactions

HCN2 HCN4

1.07e-048402int:KCNE2
GeneFamilyCyclic nucleotide gated channels

HCN2 HCN4 HCN1

3.54e-0710273250
GeneFamilyBeta 4-glycosyltransferases

CHSY1 CHSY3

2.88e-0417272425
GeneFamilyBeta 3-glycosyltransferases

CHSY1 CHSY3

5.81e-0424272426
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

KIFBP TTC28 CTR9

6.56e-04115273769
CoexpressionGSE3982_BCELL_VS_TH1_UP

VPS11 ZNF510 HCN4 FBXO21 NEK9

1.27e-05199405M5551
CoexpressionGSE33162_HDAC3_KO_VS_HDAC3_KO_4H_LPS_STIM_MACROPHAGE_UP

ARFGEF1 VPS11 APPBP2 BIRC6 NEK9

1.30e-05200405M9041
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_top-relative-expression-ranked_1000

PTBP3 PDE5A CHSY3 APPBP2 CAMKK2 CGNL1 BIRC6 LNPEP HCN1

9.95e-06811389gudmap_developingLowerUrinaryTract_e14.5_ bladder_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_top-relative-expression-ranked_100

PDE5A CHSY3 LNPEP HCN1

1.45e-0583384gudmap_developingLowerUrinaryTract_e14.5_ bladder_100
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_top-relative-expression-ranked_100

PDE5A CHSY3 LNPEP HCN1

1.91e-0589384DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_100
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#2_top-relative-expression-ranked_500

PDE5A CAMKK2 TTC28 BIRC6 LNPEP

3.39e-05209385gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_1000

PDE5A CHSY3 CAMKK2 TTC28 BIRC6 LNPEP HCN1 CRMP1

8.20e-05818388gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_500

PDE5A CHSY3 CAMKK2 TTC28 BIRC6 LNPEP

8.85e-05416386gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_top-relative-expression-ranked_200

PDE5A CHSY3 LNPEP HCN1

2.31e-04169384DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_200
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_top-relative-expression-ranked_200

PDE5A CHSY3 LNPEP HCN1

2.42e-04171384gudmap_developingLowerUrinaryTract_e14.5_ bladder_200
CoexpressionAtlasdev gonad_e11.5_M_SupCellPrec_Sry_k-means-cluster#1_top-relative-expression-ranked_100

CHD7 CAMKK2

2.80e-0414382gudmap_dev gonad_e11.5_M_SupCellPrec_Sry_k1_100
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#2_top-relative-expression-ranked_1000

PDE5A TTC28 HCN1

3.02e-0473383gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k2
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 LNPEP CRMP1 LAMA1 PROX1

6.87e-07187405c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 LNPEP CRMP1 LAMA1 PROX1

7.44e-071904051cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 LNPEP CRMP1 LAMA1 PROX1

7.44e-0719040559bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE5A CIT MGAT5B PROX1

8.41e-061444040322fef818a963be00535d5f141f028d43de5c6a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1 PROX1

1.27e-0516040403b88dc7ad41c6ae443cab7e77ec666340bf432e
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KY PDE5A HCN4 UGGT1

1.94e-05178404fcbbcc44271515de1969b4732b6441c012693d5f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1 PROX1

1.94e-051784044df6218b20c2f076c22346d23260964cc0d73e65
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1 PROX1

2.02e-05180404a17dbe03597b81e7a1fe2bf2d23e59e55c615a2a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1 PROX1

2.02e-051804049e09b3dfe344b5d50520711513d389865d73a861
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1 PROX1

2.02e-05180404eee71184ebed2694d3e60f579a44b3cf7dd2cd35
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1 PROX1

2.11e-05182404041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1 PROX1

2.25e-0518540403f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1 PROX1

2.30e-051864041850583d23903d08226aeb0edb3e07b0994330e4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1 PROX1

2.30e-051864044dafc215c42e7949f932a3627359c107943b5d6b
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDX1 KY PDE5A TTC28

2.40e-05188404a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCellfacs-Pancreas-Endocrine-24m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDX1 KY PDE5A TTC28

2.45e-05189404010fdd70e9d0e21b856306a29ff877776a480319
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

MYO3B CRMP1 LAMA1 PROX1

2.45e-05189404830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1 PROX1

2.50e-05190404b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDX1 KY PDE5A UGGT1

2.55e-05191404f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1 PROX1

2.55e-05191404f631749ef1f2270133664cf5eb4cf545a8482bd3
ToppCellCOVID-19-kidney-TAL|COVID-19 / Disease (COVID-19 only), tissue and cell type

CGNL1 CIT MYO3B LAMA1

2.55e-05191404fe55475ce0666ab5122447a813dc2369e24947b8
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDX1 KY PDE5A TTC28

2.55e-05191404a251b134f67a0a1ef3a42f50042f128a17f20b22
ToppCellCOVID-19-kidney-Mito-rich_Distal|COVID-19 / Disease (COVID-19 only), tissue and cell type

CGNL1 CIT MYO3B LAMA1

2.55e-051914040965f621ebcd92ccdeb21cc27022180ce3cfe910
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDX1 KY PDE5A TTC28

2.55e-051914043387b95a3f2445c672d407922fdce3a91eabaef8
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDX1 KY PDE5A UGGT1

2.60e-051924045b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1 PROX1

2.60e-05192404562df5e87038c500dd3a003fe5374cb31946b145
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF1 PDE5A TTC28 UGGT1

2.77e-051954043e519cffa6144a62b06124642a14c9ff39b76554
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDX1 PDE5A TTC28 UGGT1

2.77e-05195404bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDX1 PDE5A TTC28 UGGT1

2.77e-0519540458b769da05a8f6b05aeb08d4f8b112941087ad00
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF1 KY TTC28 UGGT1

2.77e-051954047796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CIT CTR9 MYO3B LAMA1

2.77e-051954045812b1615676f3b77eb4769216b98b360c417c0d
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Neuronal-INs|6_mon / Sample Type, Dataset, Time_group, and Cell type.

PTBP3 CHD7 CRMP1 PROX1

2.82e-05196404556e18eae05bf19259fe02848bcc9120aa2a9d29
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Serpinf1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE5A MGAT5B PROX1

1.66e-041194039ffdb432ec06d12eccbc9af9d30c0d24a0a21030
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LNPEP CRMP1 PROX1

2.15e-041304037d4319aae42acc914757796877b8f0d874acbec4
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Serpinf1-Serpinf1_Aqp5_Vip|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE5A MGAT5B PROX1

2.46e-041364038f5682422ba0b477c1e0700212948457f106cb10
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PDE5A HCN4 PROX1

2.62e-04139403408bc31aa5e1c2b379f79198fe8b5411f8d7bd08
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE5A CIT PROX1

2.97e-04145403590ba937c741ae67460f303eca88b1cd3ac87f64
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Htr2c|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE5A MGAT5B PROX1

3.03e-0414640347368f981180ca6a8c81a50f7f9430f12456f609
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Serpinf1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE5A MGAT5B PROX1

3.21e-041494035293c50b3fb41b1edaf9a97354899bd13770078c
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE5A MGAT5B PROX1

3.21e-0414940398ae408d2d0347865875ff8bbd89d359decea526
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 LAMA1 PROX1

3.47e-041534030307f10e772021ae68a42690634df458672a6df9
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PDE5A MYO3B PROX1

3.61e-04155403105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE5A MGAT5B PROX1

3.68e-04156403896e2d958be0a5c62fb6eebad2dfb7e1ce69f3ad
ToppCell18-Distal-Epithelial-Basal_cell|Distal / Age, Tissue, Lineage and Cell class

CHSY3 UGGT1 MYO3B

3.82e-04158403183f445967e09e871c93d8e94781ed9fec894169
ToppCellIPF-Epithelial-PNEC|IPF / Disease state, Lineage and Cell class

CGNL1 CRMP1 PROX1

3.89e-04159403adec82df944fe8699a69ca52534353bef100f2f9
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

HCN4 MYO3B PROX1

3.89e-041594037f29f9dcf25ffa1822b137c571e9ac16defc6292
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE5A MGAT5B PROX1

4.03e-04161403be77e99faf653480c166305df3a4e93db76f0dcb
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1_VIP_PCDH20|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ENPP7 HCN4 PROX1

4.18e-04163403725927926a07308013cf0c527fb6c54e99189ac0
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CGNL1 CRMP1 PROX1

4.33e-0416540350a8513d8d2630861499393a7f102b35366bad37
ToppCell356C-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

KIFBP CHSY3 ZNF510

4.64e-041694030425d2580ed325178f522c0093ff4623de6ce7a8
ToppCell356C-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

KIFBP CHSY3 ZNF510

4.64e-04169403fec669968a77060bd77ee8695034e35a642c984f
ToppCellfacs|World / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHSY1 BIRC6 LNPEP

4.81e-04171403c9990bc041a632b2f7bbebbfe737772c423d7027
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE5A CIT PROX1

4.81e-041714035efd15300f865ebf651e0888265cbd717bc3b9d3
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CGNL1 CIT PROX1

4.81e-04171403f9ae7964a3740f559431125c17c660549798cccc
ToppCellfacs-Heart-LV-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CGNL1 CIT PROX1

4.89e-04172403f2c17c49b375b28ad47dc6cabda62f1c238023dd
ToppCellfacs-Heart-LV-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CGNL1 CIT PROX1

4.89e-041724036ab4f01098dddb789df298ddf97b3c384405ee6c
ToppCellfacs|World / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHSY1 BIRC6 LNPEP

4.89e-04172403a2d0a64ebf09d219a07d6bbad1056bad6d46b9be
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE5A CIT PROX1

4.89e-041724037e1a7700a4c2b1d100da1d6e475e73498ebb605a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 LAMA1 PROX1

4.89e-041724031565f38266891c3acf49778838de134c5dee5460
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FER1L5 MYO3B PROX1

4.97e-041734030c74bdb40e635d906fd180412c23bf7fed61621e
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KY PDE5A HCN4

5.06e-04174403f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CGNL1 CIT PROX1

5.06e-04174403a5f2a4e3b25e6084bd7003a53da86a44f6fcf294
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYO3B LAMA1 PROX1

5.14e-04175403e5467dacf81f1f913b1719931cf1a7331434a7e7
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HCN2 CRMP1 PROX1

5.14e-041754038362a46f5804333baa84cd56d450bc147f372a7e
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HCN2 CRMP1 PROX1

5.14e-041754038b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCell3'_v3-Lung-Myeloid_Mac-Erythrophagocytic_macrophages|Lung / Manually curated celltypes from each tissue

PDX1 ENPP7 ZNF510

5.40e-04178403b63cee443cc1b7416112bf610d7c9d41e4fa37ed
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-1|TCGA-Liver / Sample_Type by Project: Shred V9

PDE5A HCN4 MEAK7

5.40e-0417840351c59dabf2d7aef1b1964f6f766d5ec07ef90f5a
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHSY3 HCN4 CRMP1

5.49e-0417940369a1b3b05c921de6343ffe6ad998aa2b804312a7
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHSY3 HCN4 CRMP1

5.49e-04179403479116ac65488c60104a053530830763ec1f95b2
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHSY3 HCN4 CRMP1

5.49e-041794031dfc0cb8b369aef35c59f3d4c52603dc9f3728c1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LNPEP CRMP1 PROX1

5.49e-0417940355bc69f107fc710db7617c428575792adfdbbcc1
ToppCellNS-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CHSY3 CGNL1 PROX1

5.49e-0417940365a96bee7bc28f5bfc20f0fd92bcc0ab2eb5e06c
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_3|368C / Donor, Lineage, Cell class and subclass (all cells)

VPS11 HERPUD2 TTC28

5.67e-04181403b193f3606554adc55c5906219d114288bb1f978a
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CHSY3 MEAK7 PROX1

5.76e-04182403d1c3cc2942faec7527a3c25869fd65c17899e5e4
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

HCN4 HCN1 PROX1

5.76e-0418240357bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CHSY3 MEAK7 PROX1

5.76e-0418240392f83f29e358000cd86a709eb8b6199761ffe8bd
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft-Tuft_L.0.7.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CHSY3 MEAK7 PROX1

5.76e-0418240302baca9a72c7b559c3e452693b3b134af804c868
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RCN2 CHD7 CRMP1

5.85e-04183403af14da45267261e775dd6dab7a4c359b181e46f1
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1

5.85e-0418340331ab55d5f3639f5964541d5eae23044dbda3356e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LNPEP CRMP1 PROX1

5.85e-0418340383592c332b1e82673f993d37c7f480befdc3dcda
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4|TCGA-Thryoid / Sample_Type by Project: Shred V9

ARFGEF1 PDE5A HCN4

5.95e-04184403d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LNPEP LAMA1 PROX1

6.04e-041854036da9a06e1514d5d5f47359a14637f02539846096
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LNPEP LAMA1 PROX1

6.04e-041854034a188e2566a75d1b4f3c879a8c241c277c4b451c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1

6.04e-04185403898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CHSY3 CGNL1 HCN1

6.14e-041864038915436d09775f2828a7678af203b1082b36e21c
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

HCN4 HCN1 PROX1

6.14e-04186403b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 LAMA1 PROX1

6.23e-0418740385e58a312fc325e4063a2d250666b99b8f99beb6
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-1|TCGA-Breast / Sample_Type by Project: Shred V9

ARFGEF1 KIFBP CTR9

6.23e-04187403a716b64ca03d9b61da765bf87f065ac9393303f1
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1

6.23e-04187403b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 LAMA1 PROX1

6.23e-0418740352b5b38bef3cc06487cf42c6fb22fb33f0c7ce2b
ToppCellwk_08-11-Epithelial-Distal_epithelial-epi-tip_early|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

RCN2 ENPP7 LAMA1

6.23e-041874035f9696097741b6e2b7b410c15c6b5ed883ed5eb2
ToppCellwk_08-11-Epithelial-Distal_epithelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

RCN2 ENPP7 LAMA1

6.23e-04187403eefffc2c6f7fa708a96e6bf07c6ce4e6c2e90847
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

ARFGEF1 BIRC6 LNPEP

6.33e-04188403ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

HCN4 HCN1 PROX1

6.33e-04188403c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1

6.43e-04189403f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CGNL1 MYO3B LAMA1

6.53e-041904033dcadabbefe0128a5f30ab51234f049ab4d870c6
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-Immature_INs|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

PTBP3 CHD7 PROX1

6.53e-04190403842760bfe0a52e67bad800efa7d99448a4a23ebb
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LNPEP MYO3B LAMA1

6.63e-041914039032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCelldroplet-Lung-LUNG-1m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CGNL1 TTC28 LAMA1

6.63e-04191403c379a499dabf3c9ed80f47adbb2d949821c5b053
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LNPEP MYO3B LAMA1

6.63e-041914035717809a1476c20f65bce722c5a57cff92ee0d7a
Drugzatebradine

HCN2 HCN4 BIRC6 HCN1

1.91e-0817404CID000065637
Drugbupranolol

HCN2 HCN4 BIRC6 HCN1

4.51e-0663404CID000002475
DrugHCNs

HCN2 HCN4 HCN1

5.61e-0620403CID006857665
Drugzatebradine

HCN2 HCN4

9.02e-063402ctd:C043636
DrugMethantheline bromide [53-46-3]; Up 200; 9.6uM; HL60; HT_HG-U133A

CAMKK2 HCN4 MEAK7 LNPEP PROX1

2.37e-051974056137_UP
DrugRp-8-CPT-cAMPS

PDE5A HCN2 HCN1

3.16e-0535403CID010413188
Druglichenan

VPS11 KIFBP LAMA1

3.74e-0537403CID000439241
Drugivabradine

HCN2 HCN4 HCN1

4.39e-0539403CID000132999
Drug4-ethylsulfonylnaphthalene-1-sulfonamide

HCN2 HCN4 HCN1 CRMP1

6.38e-05123404CID000013296
Diseasewaist-hip ratio

ARFGEF1 KY PDE5A VPS11 APPBP2 CAMKK2 TTC28 HCN4 BIRC6 MYO3B PROX1

3.49e-0712263911EFO_0004343
Diseasemeningitis (biomarker_via_orthology)

HCN2 HCN1

1.70e-062392DOID:9471 (biomarker_via_orthology)
Diseasesick sinus syndrome (implicated_via_orthology)

HCN4 HCN1

5.10e-063392DOID:13884 (implicated_via_orthology)
Diseasevitamin supplement exposure measurement, cleft lip

TTC28 MEAK7

1.11e-0412392EFO_0003959, EFO_0009116
Diseaseupper aerodigestive tract neoplasm

TTC28 BIRC6 MEAK7 HCN1

3.08e-04246394EFO_0004284
Diseasevelopharyngeal dysfunction

TTC28 CRMP1 LAMA1

5.65e-04122393EFO_0009336
Diseasecoronary artery disease

VPS11 KIFBP HCN4 FBXO21 NEK9 LNPEP HCN1

8.62e-041194397EFO_0001645
Diseasephotoreceptor cell layer thickness measurement

CHD7 MEAK7 PROX1

9.90e-04148393EFO_0803370

Protein segments in the cluster

PeptideGeneStartEntry
NYHYMSQVKNANDAN

BIRC6

4556

Q9NR09
YLQQNGVQNYMKYAD

CUL5

221

Q93034
FQNAVMYNDSDHHVY

BRD8

1176

Q9H0E9
YSVYADQVNIDYLMN

AKAP4

156

Q5JQC9
DKFNKEVMYAYVDQH

ARFGEF1

756

Q9Y6D6
HLASLYNYDMNQYEN

APPBP2

476

Q92624
LTHFDHYNQYEQQKM

CHD7

66

Q9P2D1
QYAFQDKNHLYLVME

CIT

161

O14578
HYAMQEAKQQFVEYD

RCN2

96

Q14257
DYYNALNLYMHQVLI

FBXO21

281

O94952
LQHDNIIAYYNHFMD

NEK9

106

Q8TD19
EVYVMVLENANHNFY

KY

636

Q8NBH2
NKYMEIHGTVYYESQ

MGAT5B

486

Q3V5L5
MNGEEQYYAATQLYK

PDX1

1

P52945
EHDANKINYMYAQYV

PDE5A

401

O76074
KVNINMNGYYIVHYA

LNPEP

691

Q9UIQ6
YNDHYMYLNHGQQTI

MEAK7

341

Q6P9B6
QYQEKYKQVEQYMSF

HCN4

526

Q9Y3Q4
QYQEKYKQVEQYMSF

HCN1

406

O60741
MELYFGEYQHVQQEY

CGNL1

1

Q0VF96
YVEQKQYISAVQMYE

CTR9

691

Q6PD62
LAYNENDNTYYAMKV

CAMKK2

181

Q96RR4
QMYAHQYYMQYQAAV

HERPUD2

196

Q9BSE4
KYIENHGVVHNMYYN

ENPP7

86

Q6UWV6
YQEKYKQVEQYMSFH

HCN2

476

Q9UL51
VNSFQVYMAYKDVYQ

CRMP1

161

Q14194
QVYQHLEMFEKAAHY

KIFBP

216

Q96EK5
TAVYAEMYENQAKYK

FER1L5

781

A0AVI2
LIYYMAHQNQADYAV

LAMA1

2751

P25391
YYIQMEKYARQAIND

PROX1

631

Q92786
LFDLEYYVHQMDNAQ

SIL1

206

Q9H173
EYCNHEIMGKNVYYK

RNASE9

81

P60153
YEMQQLFYENYEQNK

CHSY1

271

Q86X52
YEMQQLFHENYEHNR

CHSY3

361

Q70JA7
YLYEQGKLFQQIMHY

VPS11

681

Q9H270
NAHYAKMALDGQNIY

PTBP3

231

O95758
VYQQMGEYDTALQYH

TTC28

1006

Q96AY4
YEHNKNMKALNYNEN

ZNF510

226

Q9Y2H8
MANEYNFQYELVQYK

UGGT1

1306

Q9NYU2
IQYYFNQHVFALEQM

MYO3B

746

Q8WXR4