Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	store-operated calcium channel activity	TRPC7 TRPC4 TRPC5	2.75e-05	12	102	3	GO:0015279
GeneOntologyMolecularFunction	inositol 1,4,5 trisphosphate binding	TRPC7 TRPC4 TRPC5	4.52e-05	14	102	3	GO:0070679
GeneOntologyMolecularFunction	phosphatidylinositol phospholipase C activity	PLCB1 PLCB2 PLCL1	3.09e-04	26	102	3	GO:0004435
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC25A27 TRPC7 TRPC4 TRPC5 RHAG SLC6A1 SLC9A4 SLC16A3 ABCC8 SLC9A6 SLC4A11	3.59e-04	627	102	11	GO:0022890
GeneOntologyMolecularFunction	ribosome binding	NOMO1 NOMO2 ABCE1 EIF3C NOMO3	3.77e-04	120	102	5	GO:0043022
GeneOntologyMolecularFunction	phospholipase C activity	PLCB1 PLCB2 PLCL1	4.29e-04	29	102	3	GO:0004629
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC25A27 TRPC7 TRPC4 TRPC5 BEST3 RHAG SLC6A1 SLC9A4 SLC16A3 ABCC8 SLC9A6 SLC4A11	4.85e-04	758	102	12	GO:0015318
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	RASA1 RFC1 SMC2 TUFM DMC1 ARHGAP5 CLPB ABCA5 ABCE1 ABCC8 EIF5B CHD6	5.90e-04	775	102	12	GO:0017111
GeneOntologyMolecularFunction	ribonucleoprotein complex binding	NOMO1 NOMO2 ABCE1 EIF3C PPIH NOMO3	6.63e-04	206	102	6	GO:0043021
GeneOntologyMolecularFunction	transporter activity	VMP1 SLC25A27 TRPC7 TRPC4 TRPC5 BEST3 APOB RHAG SLC6A1 SLC9A4 SLC16A3 ABCA5 ABCC8 SLC15A5 SLC9A6 SLC4A11	8.10e-04	1289	102	16	GO:0005215
GeneOntologyMolecularFunction	pyrophosphatase activity	RASA1 RFC1 SMC2 TUFM DMC1 ARHGAP5 CLPB ABCA5 ABCE1 ABCC8 EIF5B CHD6	1.18e-03	839	102	12	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	RASA1 RFC1 SMC2 TUFM DMC1 ARHGAP5 CLPB ABCA5 ABCE1 ABCC8 EIF5B CHD6	1.19e-03	840	102	12	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	RASA1 RFC1 SMC2 TUFM DMC1 ARHGAP5 CLPB ABCA5 ABCE1 ABCC8 EIF5B CHD6	1.19e-03	840	102	12	GO:0016818
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	GPLD1 PLCB1 PLCB2 PLCL1	1.55e-03	97	102	4	GO:0008081
GeneOntologyMolecularFunction	alcohol binding	TRPC7 TRPC4 TRPC5 SOAT2	1.86e-03	102	102	4	GO:0043178
GeneOntologyMolecularFunction	ATP hydrolysis activity	RFC1 SMC2 DMC1 CLPB ABCA5 ABCE1 ABCC8 CHD6	1.91e-03	441	102	8	GO:0016887
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC25A27 TRPC7 TRPC4 TRPC5 SLC6A1 SLC9A4 SLC16A3 ABCC8 SLC9A6 SLC4A11	2.11e-03	664	102	10	GO:0008324
GeneOntologyMolecularFunction	potassium:proton antiporter activity	SLC9A4 SLC9A6	2.26e-03	14	102	2	GO:0015386
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC25A27 TRPC7 TRPC4 TRPC5 BEST3 SLC6A1 SLC9A4 SLC16A3 ABCC8 SLC9A6 SLC4A11	2.41e-03	793	102	11	GO:0015075
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	TRPC7 TRPC4 TRPC5 SLC6A1 SLC9A4 ABCC8 SLC9A6 SLC4A11	2.65e-03	465	102	8	GO:0046873
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC25A27 TRPC7 TRPC4 TRPC5 BEST3 RHAG SLC6A1 SLC9A4 SLC16A3 ABCA5 ABCC8 SLC15A5 SLC9A6 SLC4A11	2.67e-03	1180	102	14	GO:0022857
GeneOntologyMolecularFunction	phospholipase activity	GPLD1 PLCB1 PLCB2 PLCL1	2.79e-03	114	102	4	GO:0004620
GeneOntologyMolecularFunction	proton transmembrane transporter activity	SLC25A27 SLC9A4 SLC16A3 SLC9A6 SLC4A11	2.80e-03	188	102	5	GO:0015078
GeneOntologyMolecularFunction	sodium:proton antiporter activity	SLC9A4 SLC9A6	2.96e-03	16	102	2	GO:0015385
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC6A1 SLC9A4 SLC16A3 ABCA5 ABCC8 SLC15A5 SLC9A6 SLC4A11	3.09e-03	477	102	8	GO:0022804
GeneOntologyMolecularFunction	GTPase activator activity	RASA1 ARHGAP15 ARHGAP5 ARHGAP12 PLCB1 ALDH1A1	3.10e-03	279	102	6	GO:0005096
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC6A1 SLC9A4 SLC16A3 SLC15A5 SLC9A6 SLC4A11	4.14e-03	296	102	6	GO:0015291
GeneOntologyMolecularFunction	secondary active monocarboxylate transmembrane transporter activity	SLC6A1 SLC16A3	4.17e-03	19	102	2	GO:0015355
GeneOntologyMolecularFunction	solute:potassium antiporter activity	SLC9A4 SLC9A6	4.17e-03	19	102	2	GO:0022821
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RASA1 ARHGAP15 OBSCN ELMO1 ARHGAP5 ARHGAP12 PLCB1 ALDH1A1	4.46e-03	507	102	8	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	RASA1 ARHGAP15 OBSCN ELMO1 ARHGAP5 ARHGAP12 PLCB1 ALDH1A1	4.46e-03	507	102	8	GO:0030695
GeneOntologyBiologicalProcess	multi-pass transmembrane protein insertion into ER membrane	NOMO1 NOMO2 NOMO3	9.65e-06	9	102	3	GO:0160063
GeneOntologyCellularComponent	multi-pass translocon complex	NOMO1 NOMO2 NOMO3	9.27e-06	9	102	3	GO:0160064
GeneOntologyCellularComponent	ER membrane insertion complex	NOMO1 NOMO2 NOMO3	3.95e-05	14	102	3	GO:0072379
Domain	DUF2012	NOMO1 NOMO2 NOMO3	6.12e-07	4	101	3	PF09430
Domain	DUF2012	NOMO1 NOMO2 NOMO3	6.12e-07	4	101	3	IPR019008
Domain	TRP_2	TRPC7 TRPC4 TRPC5	3.03e-06	6	101	3	PF08344
Domain	TRP_dom	TRPC7 TRPC4 TRPC5	3.03e-06	6	101	3	IPR013555
Domain	TRPC_channel	TRPC7 TRPC4 TRPC5	5.29e-06	7	101	3	IPR002153
Domain	Carb-bd-like_fold	NOMO1 NOMO2 NOMO3	8.43e-06	8	101	3	IPR013784
Domain	TRP_channel	TRPC7 TRPC4 TRPC5	2.45e-05	11	101	3	IPR004729
Domain	PPR_long	LRPPRC PTCD1	2.90e-05	2	101	2	IPR033443
Domain	PPR_long	LRPPRC PTCD1	2.90e-05	2	101	2	PF17177
Domain	CarboxyPept_regulatory_dom	NOMO1 NOMO2 NOMO3	4.22e-05	13	101	3	IPR014766
Domain	-	NOMO1 NOMO2 NOMO3	4.22e-05	13	101	3	2.60.40.1120
Domain	EF-hand_like	PLCB1 PLCB2 PLCL1	6.66e-05	15	101	3	PF09279
Domain	PI-PLC-Y	PLCB1 PLCB2 PLCL1	6.66e-05	15	101	3	PF00387
Domain	PLCYc	PLCB1 PLCB2 PLCL1	6.66e-05	15	101	3	SM00149
Domain	PLipase_C_Pinositol-sp_Y	PLCB1 PLCB2 PLCL1	6.66e-05	15	101	3	IPR001711
Domain	PIPLC_Y_DOMAIN	PLCB1 PLCB2 PLCL1	6.66e-05	15	101	3	PS50008
Domain	PI-PLC_fam	PLCB1 PLCB2 PLCL1	6.66e-05	15	101	3	IPR001192
Domain	PLC_EF-hand-like	PLCB1 PLCB2 PLCL1	6.66e-05	15	101	3	IPR015359
Domain	PLC-beta_C	PLCB1 PLCB2	8.66e-05	3	101	2	PF08703
Domain	PPR_3	LRPPRC PTCD1	8.66e-05	3	101	2	PF13812
Domain	PLC-beta_C	PLCB1 PLCB2	8.66e-05	3	101	2	IPR014815
Domain	Fer4	DPYD ABCE1	8.66e-05	3	101	2	PF00037
Domain	CarboxyPept-like_regulatory	NOMO1 NOMO2 NOMO3	9.88e-05	17	101	3	IPR008969
Domain	PI-PLC-X	PLCB1 PLCB2 PLCL1	1.18e-04	18	101	3	PF00388
Domain	PLCXc	PLCB1 PLCB2 PLCL1	1.18e-04	18	101	3	SM00148
Domain	AAA	RFC1 DMC1 CLPB ABCA5 ABCE1 ABCC8	1.31e-04	144	101	6	SM00382
Domain	AAA+_ATPase	RFC1 DMC1 CLPB ABCA5 ABCE1 ABCC8	1.31e-04	144	101	6	IPR003593
Domain	PIPLC_X_DOMAIN	PLCB1 PLCB2 PLCL1	1.40e-04	19	101	3	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCB1 PLCB2 PLCL1	1.40e-04	19	101	3	IPR000909
Domain	PPR	LRPPRC PTCD1	1.73e-04	4	101	2	PF01535
Domain	PLC-beta	PLCB1 PLCB2	1.73e-04	4	101	2	IPR016280
Domain	4Fe4S_Fe_S_CS	DPYD ABCE1	1.73e-04	4	101	2	IPR017900
Domain	4FE4S_FER_1	DPYD ABCE1	1.73e-04	4	101	2	PS00198
Domain	Rho_GTPase_act	ARHGAP15 ARHGAP12	1.73e-04	4	101	2	IPR015767
Domain	4Fe4S_Fe-S-bd	DPYD ABCE1	2.86e-04	5	101	2	IPR017896
Domain	4FE4S_FER_2	DPYD ABCE1	2.86e-04	5	101	2	PS51379
Domain	-	PLCB1 PLCB2 PLCL1	3.24e-04	25	101	3	3.20.20.190
Domain	PLC-like_Pdiesterase_TIM-brl	PLCB1 PLCB2 PLCL1	3.24e-04	25	101	3	IPR017946
Domain	PH_12	ELMO1 PLCL1	4.28e-04	6	101	2	PF16457
Domain	PH_dom-like	RASA1 ARHGAP15 OBSCN APBB2 ELMO1 ARHGAP12 PLCB1 PLCB2 PLCL1	5.03e-04	426	101	9	IPR011993
Domain	P-loop_NTPase	RFC1 SMC2 TUFM DMC1 ARHGAP5 NOD1 CLPB ABCA5 ABCE1 ABCC8 HS6ST1 EIF5B CHD6	6.44e-04	848	101	13	IPR027417
Domain	-	RFC1 SMC2 TUFM DMC1 ARHGAP5 NOD1 CLPB ABCA5 ABCE1 ABCC8 EIF5B CHD6	6.93e-04	746	101	12	3.40.50.300
Domain	PPR	LRPPRC PTCD1	7.94e-04	8	101	2	PS51375
Domain	NaH_exchanger	SLC9A4 SLC9A6	1.02e-03	9	101	2	IPR004709
Domain	Rho_GTPase_activation_prot	RASA1 ARHGAP15 ARHGAP5 ARHGAP12	1.33e-03	88	101	4	IPR008936
Domain	ABC_transporter_CS	ABCA5 ABCE1 ABCC8	1.51e-03	42	101	3	IPR017871
Domain	Cation/H_exchanger_CPA1	SLC9A4 SLC9A6	1.54e-03	11	101	2	IPR018422
Domain	HTH_Tnp_Tc5	DCHS2 POGZ	2.17e-03	13	101	2	PF03221
Domain	ABC_tran	ABCA5 ABCE1 ABCC8	2.23e-03	48	101	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA5 ABCE1 ABCC8	2.23e-03	48	101	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCA5 ABCE1 ABCC8	2.36e-03	49	101	3	PS00211
Domain	ABC_transporter-like	ABCA5 ABCE1 ABCC8	2.50e-03	50	101	3	IPR003439
Domain	Na_H_Exchanger	SLC9A4 SLC9A6	2.53e-03	14	101	2	PF00999
Domain	Cation/H_exchanger	SLC9A4 SLC9A6	2.53e-03	14	101	2	IPR006153
Domain	PH	RASA1 ARHGAP15 OBSCN ELMO1 ARHGAP12 PLCL1	4.01e-03	278	101	6	SM00233
Domain	PH_DOMAIN	RASA1 ARHGAP15 OBSCN ELMO1 ARHGAP12 PLCL1	4.08e-03	279	101	6	PS50003
Domain	PH_domain	RASA1 ARHGAP15 OBSCN ELMO1 ARHGAP12 PLCL1	4.16e-03	280	101	6	IPR001849
Domain	EFTu-like_2	TUFM EIF5B	4.19e-03	18	101	2	IPR004161
Domain	GTP_EFTU_D2	TUFM EIF5B	4.19e-03	18	101	2	PF03144
Domain	G_TR_2	TUFM EIF5B	4.19e-03	18	101	2	PS51722
Domain	RhoGAP	ARHGAP15 ARHGAP5 ARHGAP12	4.61e-03	62	101	3	SM00324
Domain	TF_GTP-bd_dom	TUFM EIF5B	4.66e-03	19	101	2	IPR000795
Domain	RhoGAP	ARHGAP15 ARHGAP5 ARHGAP12	4.82e-03	63	101	3	PF00620
Domain	RhoGAP_dom	ARHGAP15 ARHGAP5 ARHGAP12	5.04e-03	64	101	3	IPR000198
Domain	RHOGAP	ARHGAP15 ARHGAP5 ARHGAP12	5.04e-03	64	101	3	PS50238
Domain	-	ARHGAP15 ARHGAP5 ARHGAP12	5.04e-03	64	101	3	1.10.555.10
Domain	-	RASA1 ARHGAP15 OBSCN APBB2 ELMO1 ARHGAP12 PLCL1	5.33e-03	391	101	7	2.30.29.30
Pathway	REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN_1_SIGNALING	TRPC7 TRPC4 TRPC5	1.98e-05	10	79	3	M27330
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	TRPC7 TRPC4 TRPC5 PSMB8 BEST3 CP APOB RHAG SLC6A1 SLC9A4 SLC16A3 ABCA5 SLC9A6 SOAT2	2.22e-05	681	79	14	MM14985
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	TRPC7 TRPC4 TRPC5 PSMB8 BEST3 CP APOB RHAG SLC6A1 SLC9A4 SLC16A3 ABCA5 SLC9A6 SOAT2	5.21e-05	736	79	14	M27287
Pathway	WP_GPR40_PATHWAY	PLCB1 PLCB2 PLCL1	7.34e-05	15	79	3	M39526
Pubmed	Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF.	TRPC4 TRPC5 PLCB1 PLCB2	3.76e-10	5	104	4	10980202
Pubmed	Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.	TRPC7 TRPC4 TRPC5 PLCB1 PLCB2	4.25e-09	21	104	5	30270038
Pubmed	Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.	NOMO1 NOMO2 NOMO3	2.60e-08	3	104	3	36011023
Pubmed	Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.	NOMO1 NOMO2 NOMO3	2.60e-08	3	104	3	25576386
Pubmed	Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.	NOMO1 NOMO2 NOMO3	1.04e-07	4	104	3	31833031
Pubmed	A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.	NOMO1 NOMO2 NOMO3	1.04e-07	4	104	3	9267806
Pubmed	MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.	TRPC7 TRPC4 TRPC5	9.01e-07	7	104	3	15757897
Pubmed	RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways.	TRPC7 TRPC4 TRPC5	9.01e-07	7	104	3	32350291
Pubmed	TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis.	TRPC7 TRPC4 TRPC5	9.01e-07	7	104	3	36592529
Pubmed	Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models.	TRPC7 TRPC4 TRPC5	9.01e-07	7	104	3	15336983
Pubmed	TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer.	TRPC7 TRPC4 TRPC5	9.01e-07	7	104	3	38835669
Pubmed	Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes.	TRPC7 TRPC4 TRPC5	9.01e-07	7	104	3	36257322
Pubmed	Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.	NOMO1 NOMO2 NOMO3	1.44e-06	8	104	3	15257293
Pubmed	Subunit composition of mammalian transient receptor potential channels in living cells.	TRPC7 TRPC4 TRPC5	1.44e-06	8	104	3	12032305
Pubmed	Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels.	TRPC7 TRPC4 TRPC5	1.44e-06	8	104	3	25471572
Pubmed	Association of immunophilins with mammalian TRPC channels.	TRPC7 TRPC4 TRPC5	1.44e-06	8	104	3	15199065
Pubmed	Substrate-driven assembly of a translocon for multipass membrane proteins.	NOMO1 NOMO2 NOMO3	2.15e-06	9	104	3	36261522
Pubmed	Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels.	TRPC7 TRPC4 TRPC5	2.15e-06	9	104	3	11290752
Pubmed	Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion.	TRPC7 TRPC4 TRPC5	2.15e-06	9	104	3	17480026
Pubmed	Heterogeneous distribution of TRPC proteins in the embryonic cortex.	TRPC7 TRPC4 TRPC5	3.07e-06	10	104	3	18989690
Pubmed	The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons.	TRPC7 TRPC4 TRPC5	3.07e-06	10	104	3	27177420
Pubmed	An ER translocon for multi-pass membrane protein biogenesis.	NOMO1 NOMO2 NOMO3	4.21e-06	11	104	3	32820719
Pubmed	Melanopsin signalling in mammalian iris and retina.	TRPC7 TRPC4 TRPC5	7.27e-06	13	104	3	22051675
Pubmed	Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases.	RASA1 ARHGAP5	8.86e-06	2	104	2	1689011
Pubmed	Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation.	TRPC4 TRPC5	8.86e-06	2	104	2	34899056
Pubmed	Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain.	TRPC4 TRPC5	8.86e-06	2	104	2	17593972
Pubmed	Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice.	TRPC4 TRPC5	8.86e-06	2	104	2	26317356
Pubmed	Role of p120 Ras-GAP in directed cell movement.	RASA1 ARHGAP5	8.86e-06	2	104	2	10769036
Pubmed	A novel capacitative calcium entry channel expressed in excitable cells.	TRPC4 TRPC5	8.86e-06	2	104	2	9687496
Pubmed	Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels.	TRPC4 TRPC5	8.86e-06	2	104	2	22457348
Pubmed	Conserved gating elements in TRPC4 and TRPC5 channels.	TRPC4 TRPC5	8.86e-06	2	104	2	23677990
Pubmed	Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells.	TRPC4 TRPC5	8.86e-06	2	104	2	32033274
Pubmed	The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.	TRPC4 TRPC5	8.86e-06	2	104	2	17624425
Pubmed	Dependence of cell survival on correlative activities of xanthine oxidase and dihydopyrimidine dehydrogenase in human brain-derived cell culture.	DPYD XDH	8.86e-06	2	104	2	23597150
Pubmed	TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.	TRPC4 TRPC5	8.86e-06	2	104	2	30038709
Pubmed	Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap.	RASA1 ARHGAP5	8.86e-06	2	104	2	9121432
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	NPEPPS XDH SMC2 NOMO1 NOMO2 EIF5B EIF3C NOMO3	9.54e-06	344	104	8	30333137
Pubmed	Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.	TRPC7 TRPC4 TRPC5	1.71e-05	17	104	3	22411552
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	TRIM25 POGZ RFC1 SMC2 ADARB1 WDR82 EIF3C	1.80e-05	271	104	7	32433965
Pubmed	Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.	TUFM NOMO1 SLC6A1 NOMO2 NOMO3	2.07e-05	110	104	5	27889896
Pubmed	LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis.	APOB SOAT2	2.65e-05	3	104	2	23804810
Pubmed	A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q.	PLCB1 PLCB2	2.65e-05	3	104	2	11753430
Pubmed	Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory.	TRPC4 TRPC5	2.65e-05	3	104	2	28790178
Pubmed	Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization.	APOB SOAT2	2.65e-05	3	104	2	20231283
Pubmed	The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion.	RASA1 ARHGAP5	2.65e-05	3	104	2	8344248
Pubmed	Differential PI(4,5)P2 sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels.	TRPC4 TRPC5	2.65e-05	3	104	2	30755645
Pubmed	Assessment of the risk of blastomere biopsy during preimplantation genetic diagnosis in a mouse model: reducing female ovary function with an increase in age by proteomics method.	PSMB8 ALDH1A1	2.65e-05	3	104	2	24156634
Pubmed	Distinct phospholipase C-β isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure.	PLCB1 PLCB2	2.65e-05	3	104	2	23478264
Pubmed	Suppression of PLCbeta2 by endotoxin plays a role in the adenosine A(2A) receptor-mediated switch of macrophages from an inflammatory to an angiogenic phenotype.	PLCB1 PLCB2	2.65e-05	3	104	2	19850892
Pubmed	Signaling transduction pathway of angiotensin II in human mesangial cells: mediation of focal adhesion and GTPase activating proteins.	RASA1 ARHGAP5	2.65e-05	3	104	2	10092539
Pubmed	TRPC1/4/5 channels contribute to morphine-induced analgesic tolerance and hyperalgesia by enhancing spinal synaptic potentiation and structural plasticity.	TRPC4 TRPC5	2.65e-05	3	104	2	32359120
Pubmed	Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice.	APOB SOAT2	2.65e-05	3	104	2	17431188
Pubmed	Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.	TRPC4 TRPC5	2.65e-05	3	104	2	28325835
Pubmed	Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma.	TRPC4 TRPC5	2.65e-05	3	104	2	34199280
Pubmed	Dual action of the Gαq-PLCβ-PI(4,5)P2 pathway on TRPC1/4 and TRPC1/5 heterotetramers.	TRPC4 TRPC5	2.65e-05	3	104	2	30108272
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DCHS2 APBB2 POGZ ADARB1 SLC6A1 ZNF7 ARHGAP5 CLPB NOMO2 CHD6 EIF3C GFPT2 ZNF606 NR1D2	2.95e-05	1285	104	14	35914814
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	SLC25A27 TRPC7 TRPC5 SLC6A1 SLC9A4 SLC4A11	4.41e-05	212	104	6	19521566
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	NPEPPS RFC1 SMC2 TUFM LRPPRC NOMO2 INTS13 UTP4 ANAPC2	4.83e-05	560	104	9	35241646
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPC7 TRPC4 TRPC5	5.02e-05	24	104	3	33884443
Pubmed	Interaction with dopamine D2 receptor enhances expression of transient receptor potential channel 1 at the cell surface.	TRPC4 TRPC5	5.29e-05	4	104	2	18261457
Pubmed	p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking.	RASA1 ARHGAP5	5.29e-05	4	104	2	8537347
Pubmed	Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain.	PLCB1 PLCB2	5.29e-05	4	104	2	9753089
Pubmed	The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5.	TRPC4 TRPC5	5.29e-05	4	104	2	20164195
Pubmed	NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells.	TRPC4 TRPC5	5.29e-05	4	104	2	22539836
Pubmed	A critical role of VMP1 in lipoprotein secretion.	VMP1 APOB	5.29e-05	4	104	2	31526472
Pubmed	Phospholipase C-β1 potentiates glucose-stimulated insulin secretion.	PLCB1 PLCB2	5.29e-05	4	104	2	31268747
Pubmed	Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo.	EIF5B EIF3C	5.29e-05	4	104	2	12514125
Pubmed	Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis.	TRPC4 TRPC5	5.29e-05	4	104	2	32110987
Pubmed	Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs.	PLCB1 PLCB2	5.29e-05	4	104	2	9188725
Pubmed	Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells.	APOB SOAT2	5.29e-05	4	104	2	15308631
Pubmed	Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms.	TRPC4 TRPC5	5.29e-05	4	104	2	23188715
Pubmed	PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq.	PLCB1 PLCB2	5.29e-05	4	104	2	23006664
Pubmed	RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion.	RASA1 ARHGAP5	5.29e-05	4	104	2	10713673
Pubmed	Phospholipase C isozymes selectively couple to specific neurotransmitter receptors.	PLCB1 PLCB2	5.29e-05	4	104	2	9305844
Pubmed	Expression of phospholipase C beta family isoenzymes in C2C12 myoblasts during terminal differentiation.	PLCB1 PLCB2	5.29e-05	4	104	2	15174099
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPC7 TRPC4 TRPC5	5.69e-05	25	104	3	16382100
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	OBSCN LAMA2 CRAT TUFM LRPPRC CFAP54 NOD1	6.40e-05	331	104	7	29199018
Pubmed	Inhibitory co-transmission from midbrain dopamine neurons relies on presynaptic GABA uptake.	SLC6A1 ALDH1A1	8.80e-05	5	104	2	35443174
Pubmed	Formation of novel TRPC channels by complex subunit interactions in embryonic brain.	TRPC4 TRPC5	8.80e-05	5	104	2	12857742
Pubmed	Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2.	PLCB1 PLCB2	8.80e-05	5	104	2	15611108
Pubmed	Enhanced capacitative calcium entry and TRPC channel gene expression in human LES smooth muscle.	TRPC4 TRPC5	8.80e-05	5	104	2	12736151
Pubmed	Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG.	SLC25A27 RHAG	8.80e-05	5	104	2	16378686
Pubmed	The TRPM7 channel is inactivated by PIP(2) hydrolysis.	PLCB1 PLCB2	8.80e-05	5	104	2	11941371
Pubmed	TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling.	TRPC4 TRPC5	8.80e-05	5	104	2	20458742
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TRIM25 NPEPPS APOB POGZ RFC1 SMC2 TUFM NOMO1 LRPPRC CLPB ABCE1 UTP4 EIF5B EIF3C	8.94e-05	1425	104	14	30948266
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	NOMO1 PHKG2 AGO3 CLPB NOMO2 ABCE1 ANAPC2 EIF5B WDR82 EIF3C NOMO3	9.04e-05	910	104	11	36736316
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	TRIM25 RFC1 SMC2 TUFM LRPPRC ABCE1 UTP4 EIF5B	1.10e-04	486	104	8	30940648
Pubmed	Hepatic lipase maturation: a partial proteome of interacting factors.	NOMO1 NOMO2 NOMO3	1.10e-04	31	104	3	19136429
Pubmed	Expression and immunohistochemical localization of eight phospholipase C isoforms in adult male mouse cerebellar cortex.	PLCB1 PLCB2	1.32e-04	6	104	2	8739298
Pubmed	Calcium Channels Formed by Mammalian Trp Homologues.	TRPC4 TRPC5	1.32e-04	6	104	2	11390792
Pubmed	ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries.	DMC1 ALDH1A1	1.32e-04	6	104	2	26892828
Pubmed	trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.	TRPC4 TRPC5	1.32e-04	6	104	2	8646775
Pubmed	Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets.	PLCB1 PLCB2	1.32e-04	6	104	2	2841328
Pubmed	TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation.	TRPC4 TRPC5	1.32e-04	6	104	2	29373286
Pubmed	TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses.	TRPC4 TRPC5	1.32e-04	6	104	2	31536487
Pubmed	Transient receptor potential channels and their role in modulating radial glial-neuronal interaction: a signaling pathway involving mGluR5.	TRPC4 TRPC5	1.32e-04	6	104	2	25347706
Pubmed	TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.	TRPC4 TRPC5	1.32e-04	6	104	2	32414784
Pubmed	Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice.	TRPC4 TRPC5	1.32e-04	6	104	2	36476978
Pubmed	An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.	NOMO1 NOMO2 NOMO3	1.33e-04	33	104	3	30783098
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPC7 TRPC4 TRPC5	1.33e-04	33	104	3	19834762
Interaction	TRPC3 interactions	TRPC7 TRPC4 TRPC5 PLCB1 PLCB2	5.50e-07	33	99	5	int:TRPC3
Interaction	TRPC6 interactions	TRPC7 TRPC4 TRPC5 NOMO1 NOMO2 NOMO3	3.12e-06	82	99	6	int:TRPC6
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLCB1 PLCB2 PLCL1	5.84e-05	19	73	3	832
GeneFamily	Solute carriers	SLC25A27 RHAG SLC6A1 SLC9A4 SLC16A3 SLC15A5 SLC9A6 SLC4A11	1.88e-04	395	73	8	752
GeneFamily	Transient receptor potential cation channels	TRPC7 TRPC4 TRPC5	1.92e-04	28	73	3	249
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP15 ARHGAP5 ARHGAP12	1.08e-03	50	73	3	721
CoexpressionAtlas	DevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#2_top-relative-expression-ranked_1000	PATZ1 MIER3 PCDHB9 SMC2 ARHGAP5 AGO3 CIBAR1 C1R	7.36e-06	210	101	8	gudmap_developingGonad_e18.5_ovary_1000_k2
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A6 TRPC4 LAMA2 ADARB1 ELMO1 C1R GFPT2	4.56e-07	200	104	7	311fab076f2ceb258e3970eb21e39344b894042a
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRPC4 OBSCN APBB2 LAMA2 SLC6A1 PLCB1	4.99e-06	186	104	6	888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCDHB9 LAMA2 CP ADAMTS15 ALDH1A1 GFPT2	5.99e-06	192	104	6	1b228f0929b505de82a39bf64c837887b0e56701
ToppCell	Children_(3_yrs)-Mesenchymal\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL6A6 LAMA2 ADARB1 ADAMTS15 C1R GFPT2	6.74e-06	196	104	6	bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell	Adult-Mesenchymal\|Adult / Lineage, Cell type, age group and donor	COL6A6 TRPC4 LAMA2 ADARB1 C1R GFPT2	7.14e-06	198	104	6	26e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCell	Neuronal-Excitatory-eH(THEMIS)-CRABP1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DCHS2 TRPC7 TRPC4 TRPC5 TMEM163 ALDH1A1	7.56e-06	200	104	6	473e85930f433e392956a7a10ea5d09fdc2a35b1
ToppCell	Parenchymal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A6 TRPC4 LAMA2 ADARB1 ELMO1 GFPT2	7.56e-06	200	104	6	cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCell	Neuronal-Excitatory-eH(THEMIS)-CRABP1--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DCHS2 TRPC7 TRPC4 TRPC5 TMEM163 ALDH1A1	7.56e-06	200	104	6	73b7e395398fdc9aa5adb3ade675ae0168d7f46c
ToppCell	Neuronal-Excitatory-eH(THEMIS)-CRABP1---L5-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DCHS2 TRPC7 TRPC4 TRPC5 TMEM163 ALDH1A1	7.56e-06	200	104	6	c9113e7a9624499db3e66c01462159e8e8781cc4
ToppCell	Neuronal-Excitatory-eH(THEMIS)-CRABP1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DCHS2 TRPC7 TRPC4 TRPC5 TMEM163 ALDH1A1	7.56e-06	200	104	6	a737c4f535723e389ba4b957ae1fdc5162d3d951
ToppCell	Epithelial-Epithelial-D_(Clara-Club_cells)\|Epithelial / shred on cell class and cell subclass (v4)	BEST3 CP PLCB1 PLCL1 ALDH1A1	1.04e-05	123	104	5	caa1576f1b5eb592d522be61c090ac444e277ac5
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Cdh13\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DPYD TRPC4 TRPC5 TEKT5 TMEM163	1.70e-05	136	104	5	1f3000d5f105c87c80f8ae1dd2264bcd7f757a9c
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_Krt80\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TRPC4 TRPC5 OBSCN TEKT5 TMEM163	2.02e-05	141	104	5	40ef6d792e11fe10963d64eb0b606b90556c1a70
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CP APOB ZNF7 SLC15A5 ALDH1A1	2.89e-05	152	104	5	c21e2152b0130485659051d8fb7fb4589d1ec997
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 DPYD CP APOB ALDH1A1	3.08e-05	154	104	5	a5289000597068ee8d559f89bce7bce31f35dd57
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Basal_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	DCHS2 HS6ST1 ADAMTS15 MMP10 SLC4A11	4.04e-05	163	104	5	f21951e63188eb0c04675a8f81a0da495c26c007
ToppCell	Club-club-12\|World / Class top	GALE CP ABCC8 ALDH1A1 GFPT2	4.28e-05	165	104	5	9b7a31cbdcd2f96b8bd08a4cd4141b92bd5e9062
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VMP1 TRPC4 LAMA2 CP C1R	4.80e-05	169	104	5	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP15 LAMA2 CP PTCD1 SLC15A5	4.94e-05	170	104	5	fa753cc8fbd04e63c9a303da4dc17ee2ce907f92
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP15 LAMA2 CP PTCD1 SLC15A5	4.94e-05	170	104	5	03044e1436443b28dd39d5ef4fdb25c18e3a7546
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPLD1 TRPC4 TRPC5 BEST3 ABCC8	4.94e-05	170	104	5	941d637cf76918ee4b0a1833abd1a42593cb8b1a
ToppCell	Control-Fibroblasts-Pericytes\|Control / group, cell type (main and fine annotations)	TRPC4 OBSCN LAMA2 SLC6A1 PLCB1	5.08e-05	171	104	5	080003f698f867935c2bfc55d241d3650f45a0ab
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPYD PCDHB9 XDH CP ADARB1	5.82e-05	176	104	5	d30241fb8119834d6e7b59efec3f92fc7a3d1247
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122\|Adult / Lineage, Cell type, age group and donor	GPLD1 RPS4Y1 CP PLCL1 ALDH1A1	5.82e-05	176	104	5	3fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OBSCN LAMA2 PLCB1 C1R PLCL1	5.98e-05	177	104	5	bd602db857f37869ef76d14c05ef522c509f08ee
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL6A6 TRPC4 OBSCN SLC6A1 PLCB1	6.14e-05	178	104	5	185b44700f06ec58b3c09c80520502166c965fd6
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRPC7 TRPC4 TRPC5 TMEM163 ALDH1A1	6.14e-05	178	104	5	a62137d7f5fac16619f8a02844cdb0be7a794bf2
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	DCHS2 CP CFAP54 TMEM163 SLC4A11	6.30e-05	179	104	5	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRPC4 TRPC5 SLC6A1 ARHGAP12 ADAMTS15	6.47e-05	180	104	5	8f774dcacc1626e4e6492f1eb927b0ed56fbe686
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRPC7 TRPC4 TRPC5 TMEM163 ALDH1A1	6.47e-05	180	104	5	7a9aa96fb8035020640cc7d3df0c41c730516c6f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRPC4 TRPC5 BEST3 SLC6A1 ADAMTS15	6.64e-05	181	104	5	bd7e9437839bca543ca5945df43d6525e6a312a8
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DCHS2 TRPC7 TRPC4 TRPC5 TMEM163	6.64e-05	181	104	5	13270b6ba6a9c8e5681c6f40000c643ce1d9344a
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_IL7R\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DCHS2 TRPC7 TRPC4 TRPC5 TMEM163	6.64e-05	181	104	5	3e3c903b522dced6bec5dc447cc3f8bf9a9749e3
ToppCell	facs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHB9 CP ADARB1 ADAMTS15 ALDH1A1	6.82e-05	182	104	5	c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCell	facs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHB9 CP ADARB1 ADAMTS15 ALDH1A1	6.82e-05	182	104	5	dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRPC4 TRPC5 BEST3 SLC6A1 ARHGAP12	7.18e-05	184	104	5	2ba98708dfd7f1b2a661578a334684094ff453ad
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	COL6A6 LAMA2 PLCB1 C1R GFPT2	7.75e-05	187	104	5	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	COL6A6 TRPC4 LAMA2 ADARB1 ELMO1	7.75e-05	187	104	5	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPC4 APBB2 LAMA2 ABCC8 PLCL1	7.75e-05	187	104	5	15d6e158562d7d85af3ceaf955439b379c8fce81
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPC4 APBB2 LAMA2 ABCC8 PLCL1	7.75e-05	187	104	5	f62074b631fd45ad299c69d71b09267b04d656ee
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DCHS2 TRPC4 OBSCN LAMA2 SLC6A1	7.75e-05	187	104	5	8ee3bf885897efd634c3a0567637142a9f55e693
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPC4 APBB2 LAMA2 ABCC8 PLCL1	7.95e-05	188	104	5	32f22a4d8cb98fd8b8fa0fbf28ef9266d711d081
ToppCell	15-Distal-RBC\|Distal / Age, Tissue, Lineage and Cell class	CP APOB RHAG SLC6A1 SOAT2	7.95e-05	188	104	5	c68ccb1c5c21d13ddac09b16e7d466f0530bbda5
ToppCell	15-Distal-RBC-RBC\|Distal / Age, Tissue, Lineage and Cell class	CP APOB RHAG SLC6A1 SOAT2	7.95e-05	188	104	5	2534684e4932c1255c24a26ca2277ac7af0a118b
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRPC4 OBSCN LAMA2 SLC6A1 PLCB1	7.95e-05	188	104	5	ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell	Mesenchymal-pericyte_cell\|World / Lineage, Cell type, age group and donor	TRPC4 OBSCN LAMA2 SLC6A1 PLCB1	8.15e-05	189	104	5	d7ed96add29f219183c802895fbff519b627f635
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TRPC4 OBSCN APBB2 SLC6A1 PLCB1	8.35e-05	190	104	5	4eb92aef1ee868f4537483d19014d947b7684612
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRPC4 TRPC5 BEST3 SLC6A1 ARHGAP12	8.35e-05	190	104	5	3f22c118d552345f731d4d49f0bcb5765d93de3b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRPC4 TRPC5 BEST3 SLC6A1 ARHGAP12	8.35e-05	190	104	5	39ab890104b4264c68a968f920f4ccd84f0bc681
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL6A6 LAMA2 ADAMTS15 C1R GFPT2	8.35e-05	190	104	5	0fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TRPC4 OBSCN APBB2 SLC6A1 PLCB1	8.35e-05	190	104	5	7be4341e2909101d756f14031c21e705eb45e69a
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMA2 CP ADARB1 ADAMTS15 ALDH1A1	8.56e-05	191	104	5	094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BEST3 CP ADARB1 ADAMTS15 ALDH1A1	8.56e-05	191	104	5	beb5bb42bd53bce01339da9110d374901548793c
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BEST3 CP ADARB1 ADAMTS15 ALDH1A1	8.56e-05	191	104	5	6609d85fd2577633dcc067507304a6f9e5865ca3
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BEST3 CP ADARB1 ADAMTS15 ALDH1A1	8.56e-05	191	104	5	d4f535b06ad483448ab692e9900c872c78cbed60
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BEST3 CP ADARB1 ADAMTS15 ALDH1A1	8.56e-05	191	104	5	b5210de890d338602857b5907135705a507bc2b0
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMA2 CP ADAMTS15 ALDH1A1 GFPT2	8.56e-05	191	104	5	997abf0cc5873bed0372c4a333ed307fa72774d2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DPYD ARHGAP15 ELMO1 PLCB1 PLCB2	8.56e-05	191	104	5	47a2afc4102199b4bc76bd01b2967c8016186462
ToppCell	facs-Lung-3m-Mesenchymal\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMA2 CP ADAMTS15 ALDH1A1 GFPT2	8.77e-05	192	104	5	8df15085b35b86f39debd933284cb703c5dd63c2
ToppCell	Mesenchymal-matrix_fibroblast_2_cell\|World / Lineage, Cell type, age group and donor	COL6A6 LAMA2 ADAMTS15 C1R GFPT2	8.77e-05	192	104	5	a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DCHS2 NUP210L XDH TEKT5 MMP10	8.99e-05	193	104	5	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DPYD RASA1 ARHGAP15 ELMO1 PTCD1	8.99e-05	193	104	5	779276e775cb2492e8dd36436295a536084a6415
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMA2 CP ADARB1 ADAMTS15 ALDH1A1	8.99e-05	193	104	5	4c74a3f69b2cbdf139e7e66b44bd86869ac34dc0
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMA2 CP ADARB1 ADAMTS15 ALDH1A1	8.99e-05	193	104	5	ff8ceeb3cfd1bef7239df490c19d181091750833
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	COL6A6 TRPC4 LAMA2 ADARB1 GFPT2	8.99e-05	193	104	5	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL6A6 LAMA2 ADAMTS15 C1R GFPT2	8.99e-05	193	104	5	9ab47b360bee1d4f1092c2269e58acebe9584021
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRPC4 TRPC5 BEST3 SLC6A1 ARHGAP12	8.99e-05	193	104	5	c4b22b62f3cc7bf0ec0eba76e1504c236290bbc9
ToppCell	RV-02._Fibroblast_II\|RV / Chamber and Cluster_Paper	DPYD LAMA2 PLCB1 C1R GFPT2	9.21e-05	194	104	5	11c79a8c56ece42713b04b321982e41e239f07a5
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LAMA2 ADAMTS15 PLCB1 C1R GFPT2	9.44e-05	195	104	5	ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	COL6A6 TRPC4 APBB2 LAMA2 ADARB1	9.44e-05	195	104	5	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRPC4 LAMA2 CP CIBAR1 C1R	9.67e-05	196	104	5	2ab9735aa7a7e95dcf6b0bdf0427f7b57f6349ee
ToppCell	Children_(3_yrs)-Immune-monocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DPYD ARHGAP15 PLCB1 PLCB2 SCLT1	9.67e-05	196	104	5	cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SLC25A27 DPYD COL6A6 LAMA2 ELMO1	9.67e-05	196	104	5	1450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell	facs-Lung-nan\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA2 XDH CP GFPT2 NR1D2	9.67e-05	196	104	5	b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCell	facs-Lung-nan-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA2 XDH CP GFPT2 NR1D2	9.67e-05	196	104	5	787c6cd92035e0b1108c2c086c42a229016e476b
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL6A6 LAMA2 ADARB1 C1R GFPT2	9.67e-05	196	104	5	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	PBMC-Control-cDC_3\|Control / Compartment, Disease Groups and Clusters	NOMO1 DCLRE1C WDR82 PLCB2 EIF3C	9.67e-05	196	104	5	09d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A6 LAMA2 ADARB1 C1R GFPT2	9.90e-05	197	104	5	94a9603cbd3516fbcce871909693b88f20d41713
ToppCell	distal-mesenchymal-Lipofibroblast-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL6A6 LRRC2 ADAMTS15 C1R GFPT2	9.90e-05	197	104	5	865010edcd7e3f79f505fcef7b33882095994aa8
ToppCell	distal-mesenchymal-Lipofibroblast\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL6A6 LRRC2 ADAMTS15 C1R GFPT2	9.90e-05	197	104	5	ceb83bdef16b58ee16193413bfb006f7715728b2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DPYD ARHGAP15 ELMO1 TMEM163 PLCB2	9.90e-05	197	104	5	dea1d29154c585ab588e50b83c7c8de7fe24d2d4
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SLC25A27 DPYD COL6A6 LAMA2 ELMO1	9.90e-05	197	104	5	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SLC25A27 DPYD COL6A6 LAMA2 ELMO1	9.90e-05	197	104	5	11a4c417f035e554431a8f03be13b5eefa3530c0
ToppCell	COVID-19-lung-Fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	COL6A6 LAMA2 ADARB1 C1R GFPT2	1.01e-04	198	104	5	3ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	COL6A6 LAMA2 ADARB1 C1R GFPT2	1.01e-04	198	104	5	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	Bronchial_Biopsy\|World / Tissue, Lineage and Cell class of Lung Cells from 10X	RPS4Y1 SMC2 CHD6 ALDH1A1 MMP10	1.01e-04	198	104	5	f5b7013045b61fc56894f80092f799770dde1c8f
ToppCell	nucseq-Mesenchymal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL6A6 LAMA2 ADARB1 C1R GFPT2	1.01e-04	198	104	5	8f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SLC25A27 COL6A6 CP ADARB1 ADAMTS15	1.04e-04	199	104	5	a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell	Neuronal-Excitatory-eH(THEMIS)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TRPC7 TRPC4 TRPC5 TMEM163 ALDH1A1	1.06e-04	200	104	5	651ee624ab62720546cf71c2191996b5be3ce846
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Smooth_muscle-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	TRPC4 OBSCN LAMA2 SLC6A1 PLCB1	1.06e-04	200	104	5	0c648941447c738caf62f2d71e296d6cca492c8b
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A6 TRPC4 LAMA2 C1R GFPT2	1.06e-04	200	104	5	8c62f05c6042f24287a73fbdf80ff4a56f7ff403
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TRPC4 OBSCN LAMA2 SLC6A1 PLCB1	1.06e-04	200	104	5	522a51a284d2992d519c4669e1a48c8ebcc08c80
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A6 LAMA2 ADARB1 C1R GFPT2	1.06e-04	200	104	5	cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TRPC4 OBSCN LAMA2 SLC6A1 PLCB1	1.06e-04	200	104	5	94f1fa61aa82eb9f411b2b1cb759476939ab5db7
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A6 TRPC4 LAMA2 ADARB1 ELMO1	1.06e-04	200	104	5	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Crh\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DPYD TRPC7 TEKT5 TMEM163	2.91e-04	136	104	4	44f03e4f55fb2c5f8b9397142c89f7194b009cc6
ToppCell	droplet-Liver-hepatocytes-3m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD CP APOB ALDH1A1	3.90e-04	147	104	4	00619115b9a1ec2b967c2992043b41974ece63c4
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PCDHB9 RWDD3 FHIP2A GFPT2	4.00e-04	148	104	4	1186ee0d15244fee74c1d09df3967c1b69f8ddce
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8\|TCGA-Bladder / Sample_Type by Project: Shred V9	GPLD1 SLC9A4 CHD6 SPIN3	4.21e-04	150	104	4	1aa9320d97ff10994ea024751790524fe133aba9
ToppCell	droplet-Liver-nan-3m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD CP APOB ALDH1A1	4.32e-04	151	104	4	cc9632b58522e2ba3ad36a0b8d37c7c9c8b636c4
Disease	nicotine dependence (implicated_via_orthology)	TRPC7 TRPC4 TRPC5	7.19e-06	12	96	3	DOID:0050742 (implicated_via_orthology)
Disease	C-reactive protein measurement	VMP1 UBR2 DPYD DCHS2 NUP210L COQ5 APOB OR8U3 ADARB1 TUFM DMC1 SLC9A4 PTCD1 EIF3C	3.53e-05	1206	96	14	EFO_0004458
Disease	smooth surface dental caries	ARHGAP15 BBS9 ZNF827 INTS13	5.08e-05	62	96	4	EFO_0006339
Disease	prolyl 4-hydroxylase subunit alpha-2 measurement	GPLD1 C1R	6.26e-05	4	96	2	EFO_0802918
Disease	Colorectal Carcinoma	DPAGT1 DPYD OBSCN APOB ABCA5 CCNB3 ABCE1 INTS13 ABCC8 ADAMTS15	9.77e-05	702	96	10	C0009402
Disease	neurodegenerative disease (implicated_via_orthology)	UBR2 RASA1 TRPC4 TRPC5 PSMB8	1.14e-04	145	96	5	DOID:1289 (implicated_via_orthology)
Disease	complement component 1 q subcomponent-binding protein, mitochondrial measurement	GPLD1 C1R	1.56e-04	6	96	2	EFO_0020280
Disease	brain edema (implicated_via_orthology)	CP ABCC8	1.56e-04	6	96	2	DOID:4724 (implicated_via_orthology)
Disease	cognitive function measurement, self reported educational attainment	DPYD ARHGAP15 GTDC1 LRPPRC PLCL1 EIF3C NR1D2	1.64e-04	355	96	7	EFO_0004784, EFO_0008354
Disease	2-hydroxyglutaric acid measurement	ADAMTS15 PLCB1	3.72e-04	9	96	2	EFO_0010446
Disease	obesity (implicated_via_orthology)	DCHS2 ADARB1 PLCB1 PLCB2 ALDH1A1	7.00e-04	215	96	5	DOID:9970 (implicated_via_orthology)
Disease	Neurodegeneration with brain iron accumulation	CP CRAT	7.98e-04	13	96	2	cv:C2931845
Disease	platelet component distribution width	VMP1 ARHGAP15 NUP210L NPEPPS RWDD3 ELMO1 CLPB PLCB1 SPIN3	8.01e-04	755	96	9	EFO_0007984
Disease	3-hydroxy-1-methylpropylmercapturic acid measurement	DPYD ARHGAP15 GTDC1 HS6ST1 PLCB1 SLC9A6	1.04e-03	352	96	6	EFO_0007015
Disease	Colonic Neoplasms	DPYD CP RFC1 PLCB1	1.56e-03	152	96	4	C0009375
Disease	autism spectrum disorder (implicated_via_orthology)	TRPC4 TRPC5 POGZ CHD6	1.56e-03	152	96	4	DOID:0060041 (implicated_via_orthology)
Disease	Malignant tumor of colon	DPYD CP RFC1 PLCB1	1.84e-03	159	96	4	C0007102
Disease	Colorectal Neoplasms	DPAGT1 DPYD ABCA5 ABCE1 ABCC8	2.14e-03	277	96	5	C0009404
Disease	diet measurement	DPYD ARHGAP15 NUP210L MIER3 LAMA2 APOB SMC2 ADARB1 PTCD1 CHD6	2.20e-03	1049	96	10	EFO_0008111
Disease	Schizophrenia	SLC25A27 DPYD LAMA2 CP TEKT5 ADARB1 SLC6A1 PLCB1 ALDH1A1	2.35e-03	883	96	9	C0036341
Disease	alcohol consumption measurement	ARHGAP15 RFC1 RWDD3 DMC1 PHKG2 LRPPRC PLCB1 EIF5B SLC15A5 WDR82 NR1D2	2.35e-03	1242	96	11	EFO_0007878
Disease	nephrotic syndrome (biomarker_via_orthology)	APOB SOAT2	2.76e-03	24	96	2	DOID:1184 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TFVIGIAQVMHLEDF	ABCA5	366	Q8WWZ7
HVVEAGFMTTDERKL	BEST3	156	Q8N1M1
AEVKTFMFAGHDTTT	CYP4Z2P	306	Q8N1L4
KFHLMVEVTTPVHDF	CFAP54	1351	Q96N23
SFTLTAFVELMDHGI	ELMO1	156	Q92556
GVGKDVHTFAFIMDT	APBB2	661	Q92870
EEVHTMLRGVLFFST	ANAPC2	151	Q9UJX6
HMDIDKVAFTGSTEV	ALDH1A1	236	P00352
DLDITVMVFHHFGKD	CRAT	406	P43155
MVHLKADVVISAFGS	DPYD	426	Q12882
VVDSMVQHFKVTIFG	AGO3	66	Q9H9G7
KMVFHITTGSQEFDK	DMC1	96	Q14565
FGVMEEKIAHDLRFV	C1R	596	P00736
ETLVVADESMVKFHG	ADAMTS15	221	Q8TE58
LGATAFMIAAKFEEH	CCNB3	1206	Q8WWL7
HRVIKDFMIQGGDFV	PPIH	66	O43447
DSLKIEPVFHVMGFS	NOMO3	316	P69849
TDEISFLKGDMFIVH	RASA1	296	P20936
MKIFSESHKTVFVVD	INTS13	1	Q9NVM9
QIEMAHGTTTLAFKF	PSMB8	66	P28062
KHIDREFVVMFSVVD	CP	211	P00450
ADIMISFAVKEHGDF	MMP10	156	P09238
FSFTGLQHVTDKIIM	OSGEPL1	251	Q9H4B0
DSLKIEPVFHVMGFS	NOMO2	316	Q5JPE7
EVLMAIVGTHKFSSA	SLC16A3	341	O15427
TFAVVGILGHFSKTM	DPAGT1	261	Q9H3H5
EFFIHGFTVMESSVL	OR51A7	101	Q8NH64
DSLKIEPVFHVMGFS	NOMO1	316	Q15155
VAHRGMEKSLFVFTQ	NOD1	466	Q9Y239
MGHKVVVFDISVIRA	LRRC2	1	Q9BYS8
AMEVKAFAETHIKGF	LRPPRC	1086	P42704
RDFMSVELTDGHIKV	LAMA2	2386	P24043
TVVTGIEMFHKSLER	TUFM	301	P49411
HITSAKMAVSVADFG	MIER3	511	Q7Z3K6
SGLFMTFHVAVIVTE	OVOS2	291	Q6IE36
GESHAKSFVMSVVVD	ADARB1	256	P78563
TGHEFAVKIMEVTAE	PHKG2	46	P15735
FDMKGDDVIVFLHIQ	HS6ST1	81	O60243
VEVGKFVSGTEMLHL	BBS9	81	Q3SYG4
EDIHVITGALKMFFR	ARHGAP12	721	Q8IWW6
SHFVKEITVMTEGLA	OR1L1	241	Q8NH94
LVIHMEGEDVKISFS	DCHS2	2126	Q6V1P9
MVFKAEGVHTSARLV	OBSCN	2146	Q5VST9
MHTISSKVFGDILDF	PATZ1	106	Q9HBE1
KMFAKGTEITHAVVI	EIF3C	316	Q99613
SFMAVIHFAGLKAVG	GALE	81	Q14376
AKKTAFVVEHDFIMA	ABCE1	511	P61221
FHIPSFTIDFVEMKV	APOB	2656	P04114
VFDGLVRVTQEFHMK	APOB	4171	P04114
FHPEVFSMTAVSEKQ	DCLRE1C	411	Q96SD1
MDLKVEFETHFGIAH	GFPT2	76	O94808
EFITIEMLFHGKALE	CIBAR1	186	A1XBS5
GVFKFHVVITTFEMI	CHD6	566	Q8TD26
EFKDMIEDAGFHKVT	COQ5	296	Q5HYK3
MSEFQERHEVAKFIG	CLPB	411	Q9H078
ALAKAVHERFFIGVM	FHIP2A	381	Q5W0V3
STAKHEFFGVAMLEA	GTDC1	366	Q4AE62
MSVTGFTITDEKVHL	SLC15A5	1	A6NIM6
VDKMAGEVKAFFESH	NPEPPS	861	P55786
DFHEMKTFLSEVVGM	COL6A6	451	A6NMZ7
KVFQVHSDFSMEKGV	NUP210L	1631	Q5VU65
SFFHIKISGSDEGMI	PCDHB9	176	Q9Y5E1
EEVIGMVTRAHKDTF	NR1D2	251	Q14995
FDVKSGSAVHKMIVD	UTP4	171	Q969X6
LISSHGFREIEMSKF	SLC4A11	606	Q8NBS3
FVIFSIVGFMAHVTK	SLC6A1	336	P30531
IVGFMAHVTKRSIAD	SLC6A1	341	P30531
HTFDVTAMFKSIGIF	SLC9A6	281	Q92581
IVFGFTSFIMVIVHE	SAMD8	161	Q96LT4
VARKVFAAGEETAHM	RFC1	851	P35251
MFGRHFEATDILVSK	EIF5B	1171	O60841
TFVTSVGDAMAKHLV	POGZ	821	Q7Z3K3
EDIHVVTGALKMFFR	ARHGAP15	346	Q53QZ3
IFIFMGVSTVGKNHE	SLC9A4	366	Q6AI14
FMDVISIEKTGEHFR	RPS4Y1	86	P22090
ISFFHGMEKIDGTIS	TEKT5	276	Q96M29
MTEGEHIATEITAKF	ARHGAP5	901	Q13017
DTHMKEILIFAFAGF	OR8U3	191	Q8NH85
VAMLGVFLVSAVAHE	SOAT2	421	O75908
FFRMVDTFEGHIIID	ABCC8	1391	Q09428
HDDLMSVVVFKITGV	UHRF1BP1L	1186	A0JNW5
FVGDIMEHVTLFVHI	PLCL1	831	Q15111
DGTVFRIHTKAEGFM	RWDD3	31	Q9Y3V2
SFIRLIDAFKGVVMH	WDR82	216	Q6UXN9
EIMVGKAVEHIFETE	SPIN3	126	Q5JUX0
GFVIFFAVADKVHLM	TRIM25	586	Q14258
VAFLFGITSHMAADV	GPLD1	116	P80108
MVTYEHLREVVFGKS	SLC25A27	106	O95847
EIFKASDIGASMTIH	RHAG	161	Q02094
FMKTGTVVALEVDHF	XDH	851	P47989
STMEHEFSIKERGFE	SCLT1	546	Q96NL6
MVHGSVTFRDVAIDF	ZNF780A	1	O75290
MVHGSVTFRDVAIDF	ZNF780B	1	Q9Y6R6
ITHGFTMTTEISFKE	PLCB1	376	Q9NQ66
IITHGFTMTTDIFFK	PLCB2	371	Q00722
THSQFIVVSLKEGMF	SMC2	1136	O95347
FVTMEEAEIKTHIGT	ZNF827	936	Q17R98
DVFKFSIELFHTMGR	TTC23	131	Q5W5X9
KARHEFTEFVGATMF	TRPC5	591	Q9UL62
KGHVVTEETFSFLLM	PTCD1	276	O75127
KETGMESVIEAVAHF	UBR2	806	Q8IWV8
VMGFSILLSAEVFKH	TMEM163	231	Q8TC26
VKAQHEFTEFVGATM	TRPC4	586	Q9UBN4
MEVVTFGDVAVHFSR	ZNF7	1	P17097
FSSFMEHQKIGTVEK	ZNF606	356	Q8WXB4
MKFVAHAVSFTIFLG	TRPC7	386	Q9HCX4
TFSKHIVEQMVAFIG	VMP1	311	Q96GC9