Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	NFE2L3 HIVEP3 GFI1B ZNF492 HNF1B ZNF676 USF3 ZNF211 ZNF486 ZNF100 ZSCAN20 ESR1 ZNF846 ZNF735 ZNF483 ZNF431 ZNF91 ZNF229 ZNF726	4.82e-06	1412	84	19	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	NFE2L3 HIVEP3 GFI1B ZNF492 HNF1B ZNF676 USF3 ZNF211 ZNF486 ZNF100 ZSCAN20 ESR1 ZNF846 ZNF735 ZNF483 ZNF431 ZNF91 ZNF229 ZNF726	7.73e-06	1459	84	19	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NFE2L3 HIVEP3 GFI1B ZNF492 HNF1B ZNF676 ZNF211 ZNF486 ZNF100 ZSCAN20 ESR1 ZNF735 ZNF483 ZNF431 ZNF91 ZNF229 ZNF726	1.37e-05	1244	84	17	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	NFE2L3 HIVEP3 GFI1B ZNF492 HNF1B ZNF676 ZNF211 ZNF486 ZNF100 ZSCAN20 ESR1 ZNF735 ZNF483 ZNF431 ZNF91 ZNF229 ZNF726	1.81e-05	1271	84	17	GO:0000987
GeneOntologyBiologicalProcess	protein-DNA complex organization	MEAF6 DCAF1 ZNF462 GFI1B HNF1B ESR1 EPC1 SHPRH SENP6 MLLT6 POGZ UBN2 ATAD2 ZNF726 EMSY	1.27e-05	999	85	15	GO:0071824
Domain	ZINC_FINGER_C2H2_2	ZNF462 HIVEP3 GFI1B ZNF492 ZNF676 ZNF211 ZNF486 ZNF100 ZSCAN20 ZNF592 ZNF846 ZNF735 ZNF483 SCAPER ZNF431 POGZ ZNF91 ZNF229 ZNF726	1.15e-09	775	84	19	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF462 HIVEP3 GFI1B ZNF492 ZNF676 ZNF211 ZNF486 ZNF100 ZSCAN20 ZNF592 ZNF846 ZNF735 ZNF483 SCAPER ZNF431 POGZ ZNF91 ZNF229 ZNF726	1.20e-09	777	84	19	PS00028
Domain	zf-C2H2	ZNF462 HIVEP3 GFI1B ZNF492 ZNF676 ZNF211 ZNF486 ZNF100 ZSCAN20 ZNF592 ZNF846 ZNF735 ZNF483 ZNF431 POGZ ZNF91 ZNF229 ZNF726	1.37e-09	693	84	18	PF00096
Domain	zf-C2H2_6	GFI1B ZNF492 ZNF676 ZNF211 ZNF486 ZNF100 ZNF846 ZNF735 ZNF483 ZNF431 ZNF91 ZNF229 ZNF726	1.44e-09	314	84	13	PF13912
Domain	Znf_C2H2-like	ZNF462 HIVEP3 GFI1B ZNF492 ZNF676 ZNF211 ZNF486 ZNF100 ZSCAN20 ZNF592 ZNF846 ZNF735 ZNF483 SCAPER ZNF431 POGZ ZNF91 ZNF229 ZNF726	1.80e-09	796	84	19	IPR015880
Domain	Znf_C2H2	ZNF462 HIVEP3 GFI1B ZNF492 ZNF676 ZNF211 ZNF486 ZNF100 ZSCAN20 ZNF592 ZNF846 ZNF735 ZNF483 SCAPER ZNF431 POGZ ZNF91 ZNF229 ZNF726	2.16e-09	805	84	19	IPR007087
Domain	ZnF_C2H2	ZNF462 HIVEP3 GFI1B ZNF492 ZNF676 ZNF211 ZNF486 ZNF100 ZSCAN20 ZNF592 ZNF846 ZNF735 ZNF483 SCAPER ZNF431 POGZ ZNF91 ZNF229 ZNF726	2.30e-09	808	84	19	SM00355
Domain	KRAB	ZNF492 ZNF676 ZNF211 ZNF486 ZNF100 ZSCAN20 ZNF846 ZNF735 ZNF483 ZNF431 ZNF91 ZNF229 ZNF726	9.99e-09	369	84	13	SM00349
Domain	KRAB	ZNF492 ZNF676 ZNF211 ZNF486 ZNF100 ZSCAN20 ZNF846 ZNF735 ZNF483 ZNF431 ZNF91 ZNF229 ZNF726	1.03e-08	370	84	13	IPR001909
Domain	-	ZNF462 HIVEP3 GFI1B ZNF492 ZNF676 ZNF211 ZNF486 ZNF100 ZSCAN20 ZNF846 ZNF735 ZNF483 ZNF431 ZNF91 ZNF229 ZNF726	4.99e-08	679	84	16	3.30.160.60
Domain	KRAB	ZNF492 ZNF676 ZNF211 ZNF486 ZNF100 ZNF846 ZNF735 ZNF483 ZNF431 ZNF91 ZNF229 ZNF726	6.70e-08	358	84	12	PS50805
Domain	Znf_C2H2/integrase_DNA-bd	ZNF462 HIVEP3 GFI1B ZNF492 ZNF676 ZNF211 ZNF486 ZNF100 ZSCAN20 ZNF846 ZNF735 ZNF483 ZNF431 ZNF91 ZNF229 ZNF726	6.74e-08	694	84	16	IPR013087
Domain	KRAB	ZNF492 ZNF211 ZNF486 ZNF100 ZNF846 ZNF735 ZNF483 ZNF431 ZNF91 ZNF229 ZNF726	5.86e-07	358	84	11	PF01352
Domain	START	STARD9 STARD3	2.02e-03	15	84	2	PF01852
Domain	START_lipid-bd_dom	STARD9 STARD3	2.02e-03	15	84	2	IPR002913
Domain	START	STARD9 STARD3	2.02e-03	15	84	2	PS50848
Domain	SEA	MUC16 MUC12	4.36e-03	22	84	2	PF01390
Domain	SEA	MUC16 MUC12	4.76e-03	23	84	2	PS50024
Domain	-	STARD9 STARD3	4.76e-03	23	84	2	3.30.530.20
Domain	SEA_dom	MUC16 MUC12	4.76e-03	23	84	2	IPR000082
Domain	START-like_dom	STARD9 STARD3	4.76e-03	23	84	2	IPR023393
Pathway	REACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC	MUC21 MUC16 MUC12	2.87e-05	16	54	3	M27410
Pathway	REACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS	MUC21 MUC16 MUC12	3.48e-05	17	54	3	M27412
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	MEAF6 HIVEP3 ZNF492 ZNF676 ZNF211 ZNF486 ZNF100 CAMK4 ESR1 ZNF735 EPC1 ZNF483 ZNF431 ATAD2 ZNF726 AFF4	3.99e-05	1387	54	16	M734
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC21 MUC16 MUC12	8.91e-05	23	54	3	M556
Pathway	REACTOME_DECTIN_2_FAMILY	MUC21 MUC16 MUC12	1.30e-04	26	54	3	M27483
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	STIM1 ZCCHC14 UBAP2 MYO9A STARD9 SEC24B COBL WNK1 FGD6 DMTN CRTC2 DOP1A FAM83B SHKBP1	2.55e-08	861	86	14	36931259
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	MEAF6 ZNF462 ZNF592 ZNF483 SHPRH SENP6 MLLT6 POGZ UBN2 ATAD2 EMSY AFF4	3.45e-08	608	86	12	36089195
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF462 HIVEP3 ZCCHC14 GFI1B ZSCAN20 ZNF592 ESR1 SCAPER MLLT6 POGZ ZNF91 ATAD2 ZNF726	9.54e-08	808	86	13	20412781
Pubmed	Mucins: a biologically relevant glycan barrier in mucosal protection.	MUC21 MUC12	6.04e-06	2	86	2	24821013
Pubmed	Differential Regulation of POC5 by ERα in Human Normal and Scoliotic Cells.	ESR1 POC5	6.04e-06	2	86	2	37239471
Pubmed	Membrane-bound mucin modular domains: from structure to function.	MUC21 MUC12	6.04e-06	2	86	2	23178705
Pubmed	Immunohistochemical characterization of prototypical endometrial clear cell carcinoma--diagnostic utility of HNF-1β and oestrogen receptor.	HNF1B ESR1	6.04e-06	2	86	2	24103020
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF211 ZNF486 ZNF100 ZNF91 ZNF229 ZNF726	6.09e-06	181	86	6	37372979
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FNIP2 DCAF1 ZCCHC14 STARD9 PACS2 COBL POGZ C2CD2L	7.86e-06	407	86	8	12693553
Pubmed	ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification.	ESR1 ATAD2	1.81e-05	3	86	2	17998543
Pubmed	Differential Expression of MUC12, MUC16, and MUC20 in Patients with Active and Remission Ulcerative Colitis.	MUC16 MUC12	1.81e-05	3	86	2	26770020
Pubmed	CUL4B renders breast cancer cells tamoxifen-resistant via miR-32-5p/ER-α36 axis.	CUL4B ESR1	1.81e-05	3	86	2	33638154
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	ZNF462 SENP6 POGZ UBN2 EMSY AFF4	1.94e-05	222	86	6	37071664
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CUL4B ZNF462 ZCCHC14 PCNX1 WNK1 C2CD2L	2.09e-05	225	86	6	12168954
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	MEAF6 CUL4B UBAP2 EML4 SENP6 MLLT6 POGZ UBN2 PLRG1 EMSY AFF4	2.34e-05	954	86	11	36373674
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF462 HIVEP3 USF3 SCAPER UBN2 WNK1 FGD6 DOP1A	3.11e-05	493	86	8	15368895
Pubmed	VprBP/DCAF1 Regulates the Degradation and Nonproteolytic Activation of the Cell Cycle Transcription Factor FoxM1.	CUL4B DCAF1	3.61e-05	4	86	2	28416635
Pubmed	The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps.	HNF1B INHBA	3.61e-05	4	86	2	21281489
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	SHPRH WNK1 SHROOM2 FGD6 CRTC2 SHKBP1	4.22e-05	255	86	6	15324660
Pubmed	Human transcription factor protein interaction networks.	MEAF6 ZNF462 HNF1B SINHCAF UBAP2 ZNF592 ESR1 SEC24B EPC1 MLLT6 POGZ UBN2 EMSY	4.81e-05	1429	86	13	35140242
Pubmed	SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.	CUL4B DCAF1	6.01e-05	5	86	2	24703702
Pubmed	The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα.	DCAF1 ESR1	6.01e-05	5	86	2	28068668
Pubmed	Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex.	CUL4B DCAF1	6.01e-05	5	86	2	24719410
Pubmed	A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans.	MEAF6 EPC1	6.01e-05	5	86	2	36066422
Pubmed	Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation.	CUL4B DCAF1	6.01e-05	5	86	2	36056023
Pubmed	Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV.	CAMK4 CRTC2	9.01e-05	6	86	2	16684769
Pubmed	Activin regulates estrogen receptor gene expression in the mouse ovary.	INHBA ESR1	9.01e-05	6	86	2	17951260
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	CUL4B USF3 UBAP2 ESR1 MLLT6 WNK1 CRTC2	9.76e-05	430	86	7	35044719
Pubmed	Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy.	CUL4B DCAF1	1.26e-04	7	86	2	37024504
Pubmed	Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.	CUL4B SHPRH	1.26e-04	7	86	2	23555860
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	FNIP2 ZNF492 UBAP2 SCAPER	1.28e-04	103	86	4	10819331
Pubmed	The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA.	CUL4B DCAF1	2.15e-04	9	86	2	33524014
Pubmed	Interaction network of human early embryonic transcription factors.	MEAF6 ZNF462 EPC1 POGZ UBN2 EMSY	2.41e-04	351	86	6	38297188
Pubmed	NEDD4L-mediated Merlin ubiquitination facilitates Hippo pathway activation.	CUL4B DCAF1	2.68e-04	10	86	2	33058421
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ZNF462 HIVEP3 USF3 MYO9A SHPRH COBL UBN2 SHROOM2 KRCC1 AFF4 DOP1A SHKBP1	2.96e-04	1489	86	12	28611215
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	UBAP2 ZNF592 TTLL4 SENP6 PCNX1 POGZ KCNT1	3.45e-04	529	86	7	14621295
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HIVEP3 ZCCHC14 ZNF592 TTLL4 RTTN COBL PCNX1 MLLT6 WNK1 C2CD2L	4.01e-04	1105	86	10	35748872
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	ZCCHC14 POGZ ATAD2 PLRG1 NGDN	4.70e-04	259	86	5	30404004
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	PUS10 COBL PCNX1 ZNF91 DCC	5.21e-04	265	86	5	19240061
Pubmed	Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.	INHBA ESR1 ZNF483 FAM83B	5.23e-04	149	86	4	25231870
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF91 ZNF726	6.21e-04	15	86	2	15885501
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	MYO9A ESR1 MTMR2 MUC16 PCNX1 DOP1A	6.24e-04	420	86	6	28065597
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	MYO9A SENP6 UBN2 WNK1 PLRG1 EMSY FAM83B	6.46e-04	588	86	7	38580884
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CUL4B ZNF592 EML4 SENP6 PACS2 POGZ ATAD2 EMSY	6.69e-04	774	86	8	15302935
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF100 ZNF91	7.09e-04	16	86	2	8467795
Pubmed	Impacts of humanized mouse models on the investigation of HIV-1 infection: illuminating the roles of viral accessory proteins in vivo.	CUL4B DCAF1	7.09e-04	16	86	2	25807049
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	CUL4B STIM1 WNK1 CRTC2 C2CD2L	8.83e-04	298	86	5	30737378
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC16 MUC12	9.01e-04	18	86	2	18834073
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	CUL4B ARHGAP24 ZNF100 ZSCAN20 ZNF91 ZNF726	9.02e-04	451	86	6	36168627
Pubmed	Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer.	SINHCAF ATAD2	1.01e-03	19	86	2	15334068
Pubmed	The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.	MEAF6 EPC1	1.01e-03	19	86	2	15647280
Pubmed	Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.	CUL4B ESR1	1.01e-03	19	86	2	17392787
Pubmed	CRL4DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development.	CUL4B DCAF1	1.12e-03	20	86	2	33355139
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ZNF592 ESR1 SEC24B UBN2 ATAD2 EMSY AFF4 FAM83B C2CD2L SHKBP1 NGDN	1.15e-03	1497	86	11	31527615
Pubmed	Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.	ZNF462 ZNF483 POGZ	1.16e-03	83	86	3	20562864
Pubmed	H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization.	MEAF6 EPC1	1.23e-03	21	86	2	22467210
Pubmed	Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.	DCC EMSY	1.23e-03	21	86	2	25017104
Pubmed	Immunomic analysis of human sarcoma.	MEAF6 ARHGAP24	1.23e-03	21	86	2	12601173
Pubmed	KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.	MEAF6 EPC1	1.23e-03	21	86	2	27270040
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	CUL4B MEIOC SEC24B MTMR2 COBL POC5 EMSY FAM83B	1.25e-03	853	86	8	28718761
Pubmed	A human MAP kinase interactome.	USF3 MYO9A COBL POGZ MUC12 WNK1	1.32e-03	486	86	6	20936779
Pubmed	Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.	MEAF6 EPC1	1.35e-03	22	86	2	12963728
Pubmed	Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia.	CAMK4 AFF4	1.35e-03	22	86	2	16024815
Pubmed	CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.	MEAF6 EPC1	1.48e-03	23	86	2	31281901
Pubmed	Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.	MEAF6 EPC1	1.48e-03	23	86	2	14966270
Pubmed	Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway.	CUL4B DCAF1	1.48e-03	23	86	2	22038470
Pubmed	Hundreds of variants clustered in genomic loci and biological pathways affect human height.	ZNF462 MYO9A ESR1 SENP6	1.50e-03	198	86	4	20881960
Pubmed	ATRX proximal protein associations boast roles beyond histone deposition.	ZNF592 SENP6 ATAD2	1.52e-03	91	86	3	34780483
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	STARD9 PUS10 MTMR2 POC5 ZNF229 ATAD2 FGD6	1.58e-03	686	86	7	29987050
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	CUL4B POGZ PLRG1 EMSY AFF4	1.60e-03	341	86	5	32971831
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	ESR1 GTDC1	1.61e-03	24	86	2	17452356
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	MEAF6 MFSD2A SINHCAF ZNF486 EPC1 SCAPER MUC12 ATAD2 WNK1 EMSY	1.61e-03	1327	86	10	32694731
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	CUL4B STIM1 ZNF483 SCAPER MLLT6 POC5 FGD6	1.61e-03	689	86	7	36543142
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MEAF6 CUL4B DCAF1 ZNF592 EPC1 SCAPER POGZ AFF4 C2CD2L	1.76e-03	1116	86	9	31753913
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	MYO9A SENP6 COBL DOP1A	1.80e-03	208	86	4	33230847
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	DCAF1 SENP6 PCNX1	2.04e-03	101	86	3	9872452
Pubmed	N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.	ZNF592 ZNF846 PCNX1 POGZ	2.10e-03	217	86	4	34048709
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	STIM1 UBAP2 EML4 POGZ UBN2 PLRG1 NGDN	2.13e-03	724	86	7	36232890
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	ZNF462 ZNF592 POGZ	2.16e-03	103	86	3	32744500
Pubmed	Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.	ZNF462 FAM83B	2.19e-03	28	86	2	25752541
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	UBAP2 CAMK4 SEC24B SENP6 WNK1 PLRG1 EMSY AFF4	2.20e-03	934	86	8	33916271
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CUL4B ZCCHC14 UBAP2 TTLL4 POC5 WNK1 C2CD2L	2.29e-03	733	86	7	34672954
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF91 ZNF726	2.35e-03	29	86	2	14563677
Interaction	H3-3A interactions	MEAF6 DCAF1 ZNF592 EML4 ESR1 ZNF483 SHPRH SENP6 MLLT6 POGZ UBN2 ATAD2 EMSY AFF4	2.80e-06	749	85	14	int:H3-3A
Interaction	YWHAG interactions	STIM1 UBAP2 MYO9A STARD9 ESR1 SEC24B SHPRH PACS2 COBL WNK1 SHROOM2 FGD6 DMTN CRTC2 DOP1A FAM83B C2CD2L SHKBP1	3.62e-06	1248	85	18	int:YWHAG
Interaction	YWHAH interactions	STIM1 ZCCHC14 UBAP2 MYO9A STARD9 ESR1 SEC24B PACS2 COBL WNK1 FGD6 DMTN CRTC2 DOP1A FAM83B SHKBP1	1.27e-05	1102	85	16	int:YWHAH
Interaction	ZNF726 interactions	ZNF492 ARHGAP24 ZNF726	1.55e-05	12	85	3	int:ZNF726
Interaction	TLE3 interactions	CUL4B GFI1B HNF1B ESR1 SENP6 MLLT6 UBN2 EMSY CRTC2	2.94e-05	376	85	9	int:TLE3
Interaction	ZNF716 interactions	ARHGAP24 ZNF726	5.26e-05	3	85	2	int:ZNF716
Interaction	NUP43 interactions	DCAF1 STIM1 ZNF462 ZNF592 EPC1 SENP6 MLLT6 POGZ UBN2 ATAD2 EMSY	6.22e-05	625	85	11	int:NUP43
Interaction	EGR2 interactions	MEAF6 ZNF462 EPC1 POGZ UBN2 EMSY	8.59e-05	171	85	6	int:EGR2
Interaction	ASF1A interactions	HNF1B ZNF592 ESR1 MLLT6 POGZ UBN2 EMSY	8.79e-05	249	85	7	int:ASF1A
Interaction	CRX interactions	ZNF462 HNF1B EPC1 ZNF483 MLLT6 POGZ UBN2	9.95e-05	254	85	7	int:CRX
Cytoband	19p12	ZNF492 ZNF676 ZNF486 ZNF100 ZNF431 ZNF91 ZNF726	4.16e-10	90	86	7	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF492 ZNF676 ZNF486 ZNF100 ZNF431 ZNF91 ZNF726	3.55e-09	122	86	7	chr19p12
Cytoband	6q24.3	ADGB SHPRH	1.89e-04	11	86	2	6q24.3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF462 HIVEP3 GFI1B ZNF492 ZNF676 ZNF211 ZNF486 ZNF100 ZSCAN20 ZNF592 ZNF846 ZNF735 ZNF483 SCAPER ZNF431 ZNF91 ZNF229 ZNF726	4.96e-12	718	58	18	28
GeneFamily	CD molecules\|Mucins	MUC21 MUC16 MUC12	4.00e-05	21	58	3	648
GeneFamily	StAR related lipid transfer domain containing	STARD9 STARD3	1.03e-03	15	58	2	759
Drug	estradiol; Up 200; 0.01uM; MCF7; HT_HG-U133A	ZCCHC14 ESR1 SCAPER PCNX1 WNK1 C2CD2L NGDN	7.70e-06	192	85	7	5955_UP
Drug	Acetopromazine maleate salt [3598-37-6]; Down 200; 9uM; MCF7; HT_HG-U133A	ZCCHC14 ESR1 SCAPER PCNX1 POGZ WNK1 NGDN	8.24e-06	194	85	7	6832_DN
Drug	Etifenin [63245-28-3]; Down 200; 12.4uM; MCF7; HT_HG-U133A	DCAF1 ZCCHC14 HNF1B ESR1 TTLL4 PCNX1 EMSY	8.52e-06	195	85	7	4117_DN
Drug	Chloramphenicol [56-75-7]; Up 200; 12.4uM; PC3; HT_HG-U133A	CUL4B EML4 CAMK4 ESR1 PCNX1 ATAD2 EMSY	9.11e-06	197	85	7	1795_UP
Drug	Methylatropine nitrate [52-88-0]; Down 200; 11uM; MCF7; HT_HG-U133A	HIVEP3 ESR1 SCAPER SENP6 COBL PCNX1 C2CD2L	9.73e-06	199	85	7	6495_DN
Drug	Asiaticoside [16830-15-2]; Up 200; 4.2uM; MCF7; HT_HG-U133A	HNF1B ESR1 SCAPER PCNX1 GTDC1 EMSY	8.37e-05	192	85	6	7004_UP
Drug	Haloperidol [52-86-8]; Down 200; 10.6uM; MCF7; HT_HG-U133A	STIM1 CAMK4 ESR1 PCNX1 POGZ WNK1	8.61e-05	193	85	6	5273_DN
Drug	(-)-Quinpirole hydrochloride [85760-74-3]; Down 200; 15.6uM; MCF7; HT_HG-U133A	DCAF1 SENP6 EMSY AFF4 DMTN C2CD2L	8.86e-05	194	85	6	7481_DN
Drug	Beta-Escin [11072-93-8]; Down 200; 3.2uM; PC3; HT_HG-U133A	HNF1B EML4 ESR1 TTLL4 SENP6 PCNX1	8.86e-05	194	85	6	3807_DN
Drug	Androsterone [53-41-8]; Down 200; 13.8uM; MCF7; HT_HG-U133A	ZNF592 ESR1 MTMR2 SENP6 PCNX1 WNK1	8.86e-05	194	85	6	5696_DN
Drug	Carbamazepine [298-46-4]; Up 200; 17uM; PC3; HT_HG-U133A	EML4 ESR1 MTMR2 FGD6 AFF4 C2CD2L	8.86e-05	194	85	6	1805_UP
Drug	Trioxsalen [3902-71-4]; Down 200; 17.6uM; PC3; HT_HG-U133A	ZCCHC14 INHBA SCAPER SENP6 FGD6 DMTN	9.11e-05	195	85	6	5736_DN
Drug	Gallamine triethiodide [65-29-2]; Up 200; 4.4uM; MCF7; HT_HG-U133A	CUL4B DCAF1 INHBA PCNX1 DCC AFF4	9.11e-05	195	85	6	6215_UP
Drug	Megestrol acetate [595-33-5]; Up 200; 10.4uM; PC3; HT_HG-U133A	HNF1B ESR1 TTLL4 COBL PCNX1 CCDC181	9.37e-05	196	85	6	6667_UP
Drug	Flupentixol dihydrochloride cis-(Z) [2413-38-9]; Down 200; 7.8uM; PC3; HT_HG-U133A	HIVEP3 HNF1B ZNF592 PCNX1 POGZ NGDN	9.37e-05	196	85	6	6708_DN
Drug	Trifluridine [70-00-8]; Down 200; 13.6uM; PC3; HT_HG-U133A	HIVEP3 HNF1B TTLL4 COBL PCNX1 C2CD2L	9.64e-05	197	85	6	5819_DN
Drug	Zomepirac sodium salt [64092-48-4]; Down 200; 12.8uM; MCF7; HT_HG-U133A	ZCCHC14 ESR1 SCAPER PCNX1 WNK1 EMSY	9.64e-05	197	85	6	6815_DN
Drug	0225151-0000 [351320-15-5]; Down 200; 10uM; PC3; HT_HG-U133A	HIVEP3 CAMK4 ESR1 TTLL4 SCAPER AFF4	9.64e-05	197	85	6	6389_DN
Drug	Sulfanilamide [63-74-1]; Down 200; 23.2uM; PC3; HT_HG-U133A	ESR1 SCAPER PCNX1 WNK1 SHROOM2 NGDN	9.64e-05	197	85	6	4474_DN
Drug	Clopamide [636-54-4]; Up 200; 11.6uM; MCF7; HT_HG-U133A	CUL4B INHBA MTMR2 WNK1 DMTN NGDN	9.64e-05	197	85	6	5402_UP
Drug	Droperidol [548-73-2]; Up 200; 10.6uM; MCF7; HT_HG-U133A	DCAF1 STIM1 ADGB HNF1B CAMK4 C2CD2L	9.64e-05	197	85	6	2645_UP
Drug	Articaine hydrochloride [23964-57-0]; Down 200; 12.4uM; MCF7; HT_HG-U133A	INHBA ESR1 SCAPER SENP6 EMSY C2CD2L	9.64e-05	197	85	6	6517_DN
Drug	Thiorphan [76721-89-6]; Up 200; 15.8uM; MCF7; HT_HG-U133A	DCAF1 ZCCHC14 INHBA ESR1 MTMR2 AFF4	9.64e-05	197	85	6	6249_UP
Drug	Cephalexin monohydrate [23325-78-2]; Down 200; 11uM; PC3; HT_HG-U133A	HIVEP3 ZCCHC14 HNF1B MTMR2 WNK1 AFF4	9.91e-05	198	85	6	4654_DN
Drug	Clozapine [5786-21-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A	STIM1 CAMK4 ESR1 TTLL4 PCNX1 DMTN	1.02e-04	199	85	6	5265_DN
Drug	Finasteride [98319-26-7]; Down 200; 10.8uM; PC3; HT_HG-U133A	DCAF1 ARHGAP24 INHBA SCAPER WNK1 NGDN	1.02e-04	199	85	6	3744_DN
Drug	Methimazole [60-56-0]; Down 200; 35uM; MCF7; HT_HG-U133A	STIM1 HIVEP3 PCNX1 DMTN DOP1A NGDN	1.05e-04	200	85	6	4372_DN
Drug	Ivermectin [70288-86-7]; Down 200; 4.6uM; PC3; HT_HG-U133A	DCAF1 ZNF592 PCNX1 POGZ GTDC1 SHROOM2	1.05e-04	200	85	6	5853_DN
Drug	W-13, hydrochloride; Down 200; 10uM; MCF7; HG-U133A	ESR1 MTMR2 COBL PCNX1 POGZ FGD6	1.05e-04	200	85	6	643_DN
Disease	Fibroid Tumor	INHBA ESR1	1.14e-04	6	82	2	C0023267
Disease	Uterine Fibroids	INHBA ESR1	1.59e-04	7	82	2	C0042133
Disease	Intellectual Disability	ZNF462 MFSD2A RTTN SCAPER PACS2 POGZ DCC	2.50e-04	447	82	7	C3714756
Disease	gestational age	NFE2L3 HIVEP3 ZNF846 PCNX1	6.04e-04	138	82	4	EFO_0005112
Disease	peanut allergy measurement	ARHGAP24 EMSY	8.93e-04	16	82	2	EFO_0007017
Disease	platelet component distribution width	STIM1 GFI1B ZNF211 MEIOC RTTN EPC1 WNK1 FGD6	1.19e-03	755	82	8	EFO_0007984
Disease	suicidal ideation, suicide behaviour	ESR1 DCC	2.02e-03	24	82	2	EFO_0004320, EFO_0007623
Disease	unipolar depression, depressive symptom measurement	FNIP2 DCC	2.37e-03	26	82	2	EFO_0003761, EFO_0007006
Disease	PR interval	HIVEP3 MFSD2A ARHGAP24 INHBA EML4 NGDN	2.58e-03	495	82	6	EFO_0004462

Protein segments in the cluster

Peptide	Gene	Start	Entry
SHSALSHQVTAANSA	EPC1	731	Q9H2F5
ADKVSSSASSSSHHE	MLLT6	271	P55198
TSASHFSGLQAHTTT	LINC00269	56	Q8N2A0
SHISANKLTTSVNSH	ADGRG4	1216	Q8IZF6
SSQSSKHILSFHSAS	ADGB	1181	Q8N7X0
ISGTTHTLHDSSVAS	DOP1A	1241	Q5JWR5
SSLELHNHSAASATG	ATAD2	6	Q6PL18
HNHSAASATGSLDLS	ATAD2	11	Q6PL18
AVSSLNSSHSRSHGN	AFF4	186	Q9UHB7
TSGSSLSFHSTVINH	INHBA	361	P08476
STFSHHKATSSITTG	MUC16	741	Q8WXI7
NMGTASSAHVLHSTL	MUC16	4541	Q8WXI7
GTRSAHTQSLTSVHS	POC5	556	Q8NA72
FHLDSGHKTSSRVNS	DCAF1	241	Q9Y4B6
HSQSETQLGSKSTSH	DCC	1191	P43146
ALTGMHTTSHSASTA	MUC21	451	Q5SSG8
HTTSHSASTAVSEAK	MUC21	456	Q5SSG8
SASSSHGSIQESHKA	CAMK4	341	Q16566
SQSSNLITHSRKHTG	GFI1B	286	Q5VTD9
HVASSSQSRKSSCSH	KCNT1	1201	Q5JUK3
KHSSSSNSQGSIHKS	FAM83B	831	Q5T0W9
SSSVIHRTASAHKSG	PCNX1	546	Q96RV3
ASVHTLSGHTNAVAT	PLRG1	321	O43660
SHLATAGSTSSHSLQ	ESR1	566	P03372
SHNNTSVIKSNSSHS	NFE2L3	426	Q9Y4A8
GLHHVNFSDSSKSRT	LCT	816	P09848
SHSENSVHTKSASVV	MTMR2	31	Q13614
LSHSSSQTEIGSIHS	PACS2	326	Q86VP3
SSTVASQSANHTHGT	MFSD2A	231	Q8NA29
ISVSHVGSTASKNSN	PUS10	91	Q3MIT2
NSSSNHSALHSLVSS	ARHGAP24	636	Q8N264
DSTAKIHAVTHSSTG	CCDC181	271	Q5TID7
TSHSSSRDSHLSNGL	C2CD2L	491	O14523
STSNLTHTMTHLGIS	CRTC2	306	Q53ET0
ISSHSSSGGSSHHAK	FNIP2	106	Q9P278
TSSLTSSIHGASNHC	COBL	511	O75128
ASSTSSGSHHSSHKK	MEAF6	156	Q9HAF1
SSDNSTSTHQASHKQ	KRCC1	141	Q9NPI7
SSHTAFTKHSEELGT	EMSY	906	Q7Z589
SFTHNDSHLISTGGK	EML4	841	Q9HC35
STASFLSHHSTKANT	CCDC158	881	Q5M9N0
LKKSTSSDNSSSHHG	GTDC1	246	Q4AE62
FHTSLHQGTSKSSSL	DMTN	276	Q08495
GAASSASHLHTSASQ	SEC24B	136	O95487
VKAHHTGSTASSEIT	SCAPER	226	Q9BY12
SVASVHHANGLAKSS	CUL4B	166	Q13620
HHANGLAKSSTTVSS	CUL4B	171	Q13620
TSSHKTTTSFHNSGN	MUCL3	201	Q3MIW9
SSHCQLAHSSSNTVS	nan	416	A6NNC1
TSSSTISHHGNSAMV	HNF1B	361	P35680
SGSSSHAHVNSRISV	RTTN	336	Q86VV8
NSHLSAASKGSNHSS	MEIOC	501	A2RUB1
SSLSSHTAGVTEKHS	SPDYA	246	Q5MJ70
NHSFTTDHGESTSKL	SUSD3	181	Q96L08
SSAATHNSHTGAAAS	OR7A10	261	O76100
AAHASVAGHLSTSTT	POGZ	56	Q7Z3K3
SLHSASSNTSLSGHR	SHKBP1	631	Q8TBC3
RSHTNSSAKHSEASV	SHPRH	1651	Q149N8
AKSNSSIDHLGSHSK	SHROOM2	191	Q13796
IGVHFTSAVTHSSQK	OR7D2	256	Q96RA2
LAASATTLTHVGSTH	STARD9	1466	Q9P2P6
QSLSHSHSEKATGTS	STIM1	21	Q13586
SLGSSLSHSQSLSSH	STARD3	21	Q14849
KRHNSDAHSTTSSAS	SINHCAF	116	Q9NP50
NQSSTLSTHKFIHAG	ZNF431	326	Q8TF32
QSSTLTTHKITHAGE	ZNF100	356	Q8IYN0
SSHQSSLSAHAALSS	UBAP2	706	Q5T6F2
HVSSSSQAQIAASSH	UBN2	896	Q6ZU65
TSGSTSAAFHHSLTQ	UBN2	1286	Q6ZU65
GFSSVSTLNTHKAIH	ZNF676	261	Q8N7Q3
SFNHSSSGTTHKRIL	ZNF735	221	P0CB33
FTQSSGLSTHLRTHT	ZNF846	431	Q147U1
SFSKSSTLANHQRTH	ZSCAN20	911	P17040
SSQLHSLTHFSDISA	NGDN	266	Q8NEJ9
FKTASSTADHSATQH	ZNF592	836	Q92610
NHKSPSSALSSVLHS	FGD6	1296	Q6ZV73
AKSSLSQISSAATSH	HIVEP3	1081	Q5T1R4
QSSSFSSHRKVHTGE	ZNF211	436	Q13398
NESLSSTHHTDGLSK	SENP6	896	Q9GZR1
SSSATATKVHHGNKS	USF3	306	Q68DE3
SCSSHLSSHQKTHTG	ZNF229	471	Q9UJW7
SNSLENALHTSAHST	ZCCHC14	66	Q8WYQ9
SQSSTLTAHKIIHTG	ZNF726	491	A6NNF4
SQSSTLTTHKIIHTG	ZNF492	291	Q9P255
AFSNSSTLANHKITH	ZNF91	666	Q05481
LSSHSHHSSQKATPA	ZNF462	2121	Q96JM2
SHSSSLSKHQRIHTG	ZNF483	561	Q8TF39
HSSSGAQHASVSLET	WNK1	1666	Q9H4A3
ASAHIALSTASSHDT	TTLL4	281	Q14679
TTSSNLTEHKTTHTG	ZNF486	416	Q96H40
TATKHFLDSSTNSGH	MUC12	206	Q9UKN1
SGSGKTQSTNFLIHH	MYO9A	241	B2RTY4