Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DUF3523	ATAD3B ATAD3A	8.52e-06	3	32	2	PF12037
Domain	DUF3523	ATAD3B ATAD3A	8.52e-06	3	32	2	IPR021911
Domain	HOOK	CCDC88C CCDC88A	4.25e-05	6	32	2	PF05622
Domain	Hook-related_fam	CCDC88C CCDC88A	4.25e-05	6	32	2	IPR008636
Domain	CUB	NETO1 PDGFD	3.18e-03	49	32	2	PF00431
Domain	CUB	NETO1 PDGFD	3.31e-03	50	32	2	SM00042
Domain	-	NETO1 PDGFD	3.57e-03	52	32	2	2.60.120.290
Domain	AAA	ATAD3B ATAD3A	3.57e-03	52	32	2	PF00004
Domain	CUB	NETO1 PDGFD	3.71e-03	53	32	2	PS01180
Domain	ATPase_AAA_core	ATAD3B ATAD3A	3.85e-03	54	32	2	IPR003959
Domain	CUB_dom	NETO1 PDGFD	4.28e-03	57	32	2	IPR000859
Pubmed	Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles.	CCDC88C CCDC88A TJP1	5.72e-07	18	32	3	29229865
Pubmed	Molecular characterization of the tumor-associated antigen AAA-TOB3.	ATAD3B ATAD3A	8.20e-07	2	32	2	16909202
Pubmed	The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization.	ATAD3B ATAD3A	8.20e-07	2	32	2	17210950
Pubmed	ATAD 3A and ATAD 3B are distal 1p-located genes differentially expressed in human glioma cell lines and present in vitro anti-oncogenic and chemoresistant properties.	ATAD3B ATAD3A	8.20e-07	2	32	2	18639545
Pubmed	mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.	ATAD3B GTF3C1 TJP1 ATAD3A	2.01e-06	98	32	4	34943047
Pubmed	ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A.	ATAD3B ATAD3A	2.46e-06	3	32	2	22664726
Pubmed	ATAD3 is a limiting factor in mitochondrial biogenesis and adipogenesis of white adipocyte-like 3T3-L1 cells.	ATAD3B ATAD3A	2.46e-06	3	32	2	38923254
Pubmed	[ATAD3, a vital membrane-bound mitochondrial ATPase involved in tumor progression].	ATAD3B ATAD3A	2.46e-06	3	32	2	22192748
Pubmed	ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly.	ATAD3B ATAD3A	2.46e-06	3	32	2	34936866
Pubmed	ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.	ATAD3B ATAD3A	2.46e-06	3	32	2	28549128
Pubmed	Mitochondria-associated membrane formation in hormone-stimulated Leydig cell steroidogenesis: role of ATAD3.	ATAD3B ATAD3A	2.46e-06	3	32	2	25375035
Pubmed	ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.	ATAD3B ATAD3A	4.92e-06	4	32	2	35236834
Pubmed	Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis.	ATAD3B ATAD3A	4.92e-06	4	32	2	36736924
Pubmed	The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy.	ATAD3B ATAD3A	4.92e-06	4	32	2	38250153
Pubmed	Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells.	ATAD3B ATAD3A	4.92e-06	4	32	2	29242539
Pubmed	Expression analysis of ATAD3 isoforms in rodent and human cell lines and tissues.	ATAD3B ATAD3A	8.19e-06	5	32	2	24239551
Pubmed	ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels.	ATAD3B ATAD3A	8.19e-06	5	32	2	29898916
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	ATAD3B CCDC88A ATAD3A SPTA1	1.00e-05	147	32	4	16959763
Pubmed	Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation.	ATAD3B ATAD3A	1.23e-05	6	32	2	31472450
Pubmed	Planar cell polarity induces local microtubule bundling for coordinated ciliary beating.	CCDC88C TJP1	1.72e-05	7	32	2	33929515
Pubmed	ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.	ATAD3B ATAD3A	2.29e-05	8	32	2	30914652
Pubmed	Atad3 function is essential for early post-implantation development in the mouse.	ATAD3B ATAD3A	2.29e-05	8	32	2	23372768
Pubmed	Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.	CCDC88C CCDC88A	2.29e-05	8	32	2	26126266
Pubmed	Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.	CCDC88C ATAD3B CCDC88A MRPL46 PTS	2.52e-05	384	32	5	31059266
Pubmed	Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.	TJP1 ATAD3A ADCY8 RYR3	3.05e-05	195	32	4	17110338
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	ABAT ATAD3B SAFB ATAD3A	3.50e-05	202	32	4	24639526
Pubmed	Deletion of ATAD3A inhibits osteogenesis by impairing mitochondria structure and function in pre-osteoblast.	ATAD3B ATAD3A	4.49e-05	11	32	2	36000457
Pubmed	FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.	ATAD3B ATAD3A	4.49e-05	11	32	2	37279268
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	ABAT ATAD3B SAFB CCDC88A TJP1 ATAD3A DNAJC16	6.51e-05	1139	32	7	36417873
Pubmed	RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.	CCDC88C TJP1	8.55e-05	15	32	2	36260679
Pubmed	Wnts regulate planar cell polarity via heterotrimeric G protein and PI3K signaling.	CCDC88C TJP1	1.11e-04	17	32	2	32805026
Pubmed	Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.	ATAD3B SAFB ATAD3A	1.39e-04	109	32	3	29511296
Pubmed	EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia.	CCDC88C TJP1	1.87e-04	22	32	2	34001891
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	ZNF318 CCDC88A NETO1	1.99e-04	123	32	3	26912792
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CCDC88C FYCO1 ZNF318 CCDC88A NETO1 TJP1	2.17e-04	963	32	6	28671696
Pubmed	Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.	ABAT ATAD3B ATAD3A PTS	2.69e-04	343	32	4	28130547
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ATAD3B ZNF318 SAFB GTF3C1 TJP1 ATAD3A SPTA1	2.81e-04	1442	32	7	35575683
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	NIBAN1 ZNF318 SAFB GTF3C1 TJP1 ATAD3A	3.02e-04	1024	32	6	24711643
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ABAT ATAD3B GTF3C1 NETO1 TJP1 ATAD3A ARAP1	3.41e-04	1489	32	7	28611215
Pubmed	Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP.	FYCO1 SAFB	3.51e-04	30	32	2	22963397
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	ATAD3B TJP1 ATAD3A	4.22e-04	159	32	3	30581152
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	ZNF318 SPTA1 RYR3	4.95e-04	168	32	3	30631154
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	EPC2 FAM83D GTF3C1 ATAD3A	5.27e-04	410	32	4	26949251
Pubmed	Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.	CCDC88C CCDC88A PTS	5.31e-04	172	32	3	23184937
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	ATAD3B SAFB GTF3C1 ATAD3A	5.32e-04	411	32	4	35182466
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	FAM83D ATAD3B GTF3C1 TJP1 ATAD3A ARAP1	5.72e-04	1155	32	6	20360068
Pubmed	Network organization of the human autophagy system.	FYCO1 SAFB GTF3C1 TJP1	6.69e-04	437	32	4	20562859
Pubmed	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	ABAT CHRNA5 ADCY8	7.41e-04	193	32	3	20677014
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	CCDC88A NETO1 TJP1	7.87e-04	197	32	3	36604605
Pubmed	Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.	ABAT ATAD3B ATAD3A	8.58e-04	203	32	3	16916647
Pubmed	Systematic analyses of the ultraviolet radiation resistance-associated gene product (UVRAG) protein interactome by tandem affinity purification.	ATAD3B ATAD3A	9.01e-04	48	32	2	26590968
Cytoband	11q22.3	PTS PDGFD	4.37e-04	44	32	2	11q22.3
Cytoband	1p36.33	ATAD3B ATAD3A	1.33e-03	77	32	2	1p36.33
Cytoband	Ensembl 112 genes in cytogenetic band chr15q13	TJP1 RYR3	2.23e-03	100	32	2	chr15q13
Cytoband	Ensembl 112 genes in cytogenetic band chr15q25	MRPL46 CHRNA5	5.59e-03	160	32	2	chr15q25
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	GTF3C1 TMC7	6.43e-03	172	32	2	chr16p12
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	ATAD3B ATAD3A DNAJC16	1.17e-02	681	32	3	chr1p36
Cytoband	19p13.3	OAZ1 FUT3	1.19e-02	237	32	2	19p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	OAZ1 SAFB FUT3	1.78e-02	797	32	3	chr19p13
GeneFamily	AAA ATPases	ATAD3B ATAD3A	1.55e-03	53	20	2	413
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_k-means-cluster#1_top-relative-expression-ranked_500	NIBAN1 RYR3 PDGFD	3.68e-05	43	32	3	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_500_k1
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-T_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM83D GALNT12 FYCO1 ASTE1	6.22e-06	168	32	4	182f08106ac65ea501e2fb9139d3b44b7c4662c9
ToppCell	droplet-Marrow-nan-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88A GTF3C1 DNAJC16 SPTA1	6.36e-06	169	32	4	5f5bec13208f4c3b6eacbba180c8a6402743b76e
ToppCell	Goblet\|World / shred by cell class for turbinate	FAM83D GALNT12 NIBAN1 FUT3	1.10e-05	194	32	4	03b62e7cff5e7a6e7bd7d9dda273c74bf9c1f42e
Computational	Genes in the cancer module 67.	CCDC88C ZNF318 SPTA1 TTC29 PDGFD	1.23e-04	227	24	5	MODULE_67
Disease	neuromuscular disease (implicated_via_orthology)	ATAD3B ATAD3A	6.40e-06	4	31	2	DOID:440 (implicated_via_orthology)
Disease	syndrome (implicated_via_orthology)	ATAD3B ATAD3A	1.62e-04	18	31	2	DOID:225 (implicated_via_orthology)
Disease	intelligence, response to cranial radiation therapy	GTF3C1 ADCY8	3.97e-04	28	31	2	EFO_0004337, EFO_0010950
Disease	autism spectrum disorder	CCDC88C GALNT12 ADCY8	5.84e-04	156	31	3	EFO_0003756
Disease	circadian rhythm	EPC2 DNAJC16 ADCY8	6.64e-04	163	31	3	EFO_0004354
Disease	spleen volume	TJP1 SPTA1	9.39e-04	43	31	2	EFO_0600047
Disease	response to angiotensin-converting enzyme inhibitor, Cough	NIBAN1 DNAJC16	1.07e-03	46	31	2	EFO_0005325, HP_0012735
Disease	idiopathic pulmonary fibrosis	ZNF318 FUT3	1.64e-03	57	31	2	EFO_0000768
Disease	Withdrawal Symptoms	CHRNA5 ADCY8	1.70e-03	58	31	2	C0087169
Disease	Drug Withdrawal Symptoms	CHRNA5 ADCY8	1.70e-03	58	31	2	C0086189
Disease	Substance Withdrawal Syndrome	CHRNA5 ADCY8	1.70e-03	58	31	2	C0038587
Disease	microglial activation measurement	CCDC88C TTC29	1.76e-03	59	31	2	EFO_0010940
Disease	chronotype measurement	EPC2 ZNF318 DNAJC16 ADCY8 TTC29	2.10e-03	882	31	5	EFO_0008328

Protein segments in the cluster

Peptide	Gene	Start	Entry
RHFLEKDRDNEELYS	ADCY8	961	P40145
ENSELADLDKLRYRH	EPC2	421	Q52LR7
NEYLRKLSDHSVRED	ALS2	346	Q96Q42
AARELEHSRYAKDAL	ATAD3A	61	Q9NVI7
EDHSNEFFTDLKLRD	ASTE1	11	Q2TB18
ADDFENYHKLRRSSS	NETO1	411	Q8TDF5
AAEKEEDYHTALRRL	FYCO1	326	Q9BQS8
DNHASDDFFRKLRDI	ABAT	301	P80404
CRDDLLSDYFRKASD	CCDC88C	1691	Q9P219
RLLHDEQSTDDSRYK	CCDC88A	941	Q3V6T2
YHDRKSKVDLDRLND	PDGFD	251	Q9GZP0
EDYFSSHRDELQSRK	FAM83D	371	Q9H4H8
NSERRDSIDEKYLLH	DNAJC16	131	Q9Y2G8
RDHNLSANLFYSDDR	OAZ1	86	P54368
HEDSLLKDLFQDYER	CHRNA5	46	P30532
KYHDSDEATAARLLF	DCTD	131	P32321
DYSDREHLKERLANE	GALNT12	176	Q8IXK2
KAYRRALDHEEEALS	PIGS	106	Q96S52
DLARYLQELDKDHAR	FUT3	301	P21217
RSLYSDHELRALDEN	MRPL46	81	Q9H2W6
EAKRAALDERYHSDF	SAFB	726	Q15424
RLDTDHLRYFDSNKD	ARAP1	351	Q96P48
AARELEHSRYAKEAL	ATAD3B	61	Q5T9A4
LTSEDEYNLLSDRHF	NIBAN1	126	Q9BZQ8
SLAKSRYSHRDTDEE	RYR3	3391	Q15413
KHEIDSYDDRFQSAD	SPTA1	416	P02549
DDLDLHDDRLSYLSA	TJP1	811	Q07157
YHYLTRAEDAERKES	TTC29	121	Q8NA56
SKRLRYHDEADQSAL	GTF3C1	1241	Q12789
SASHRLYSKFLSDEE	PTS	21	Q03393
DEDYRTKETFLHRSD	ZNF318	221	Q5VUA4
KHSSLRYELRADLEE	TMC7	326	Q7Z402