Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA/RNA hybrid binding	POLR3B POLR1A	6.62e-05	5	52	2	GO:0071667
MousePheno	abnormal hepatic portal vein connection	BRD2 TULP4	7.19e-05	4	49	2	MP:0013814
MousePheno	abnormal external carotid artery origin	BRD2 TULP4	7.19e-05	4	49	2	MP:0013995
Domain	HMG_box	SOX5 SOX13	9.93e-03	53	53	2	PF00505
Domain	Quinoprotein_ADH-like_supfam	EML5 WDR6	9.93e-03	53	53	2	IPR011047
Domain	HMG_BOX_2	SOX5 SOX13	1.03e-02	54	53	2	PS50118
Domain	HMG	SOX5 SOX13	1.03e-02	54	53	2	SM00398
Domain	-	SOX5 SOX13	1.07e-02	55	53	2	1.10.30.10
Pubmed	Cloning and characterization of mouse mSox13 cDNA.	SOX5 SOX13	2.37e-06	2	54	2	9524265
Pubmed	Expressions of Sox9, Sox5, and Sox13 transcription factors in mice testis during postnatal development.	SOX5 SOX13	7.09e-06	3	54	2	26045173
Pubmed	Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis.	ZSCAN5DP ZSCAN5A	1.42e-05	4	54	2	31155506
Pubmed	ZSCAN5B and primate-specific paralogs bind RNA polymerase III genes and extra-TFIIIC (ETC) sites to modulate mitotic progression.	ZSCAN5DP ZSCAN5A	1.42e-05	4	54	2	27732952
Pubmed	Charge movement and transcription regulation of L-type calcium channel alpha(1S) in skeletal muscle cells.	SOX5 CACNA1S	1.42e-05	4	54	2	11956331
Pubmed	A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain.	PATZ1 BACH1	1.42e-05	4	54	2	10669750
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ZNF536 POLR3B POLR1A WDR6 NFXL1 UNK DENND4C KNL1	1.66e-05	733	54	8	34672954
Pubmed	The efficacy of serum carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 15-3 (CA15-3), alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCG) levels in determining the malignancy of solitary pulmonary nodules.	CGA MUC16	2.36e-05	5	54	2	19383238
Pubmed	Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development.	SOX5 SOX13	2.36e-05	5	54	2	16627753
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	SOX5 BRD2 ZSCAN5DP ZSCAN5A PATZ1 BACH1 UNK SOX13	3.32e-05	808	54	8	20412781
Pubmed	The transcription factor Sox5 modulates Sox10 function during melanocyte development.	SOX5 SOX13	6.59e-05	8	54	2	18703590
Pubmed	Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.	SOX5 SOX13	8.46e-05	9	54	2	12100890
Pubmed	From head to toes: the multiple facets of Sox proteins.	SOX5 SOX13	1.06e-04	10	54	2	10037800
Pubmed	Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.	SOX5 SOX13	1.55e-04	12	54	2	26525805
Pubmed	Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.	SOX5 SOX13	1.55e-04	12	54	2	7590241
Pubmed	SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system.	SOX5 SOX13	1.55e-04	12	54	2	34234180
Pubmed	Seven new members of the Sox gene family expressed during mouse development.	SOX5 SOX13	1.83e-04	13	54	2	8441686
Pubmed	Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.	SOX5 SOX13	1.83e-04	13	54	2	12194848
Pubmed	Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth.	SOX5 SOX13	2.13e-04	14	54	2	8921394
Pubmed	Interaction network of human early embryonic transcription factors.	SOX5 ZNF536 TNRC18 WDR6 SOX13	2.15e-04	351	54	5	38297188
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	POLR3B POLR1A PSME4 WDR6 PLEKHG3 SMCHD1 RPF2 NFXL1 UTP20	2.18e-04	1353	54	9	29467282
Pubmed	Differential isoform expression and alternative splicing in sex determination in mice.	SOX5 SOX13	2.45e-04	15	54	2	30871468
Pubmed	Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice.	SOX5 HOXD11	2.80e-04	16	54	2	17222543
Pubmed	Spatio-temporal expression of Sox genes in murine palatogenesis.	SOX5 SOX13	3.17e-04	17	54	2	27241892
Pubmed	Musculoskeletal integration at the wrist underlies the modular development of limb tendons.	SOX5 CACNA1S	3.17e-04	17	54	2	26062940
Pubmed	Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.	ZNF536 GALNT17	3.56e-04	18	54	2	24939585
Pubmed	Expression of Sox genes in tooth development.	SOX5 SOX13	3.56e-04	18	54	2	26864488
Pubmed	Rrn3 becomes inactivated in the process of ribosomal DNA transcription.	POLR1A MNAT1	3.98e-04	19	54	2	12646563
Pubmed	Molecular evolution of Sry and Sox gene.	SOX5 SOX13	4.42e-04	20	54	2	11404013
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	POLR1A EML5 DENND4C KNL1	4.70e-04	232	54	4	25515538
Pubmed	Quantitative trait loci for body size components in mice.	SOX5 ZNF536 BRD2	4.85e-04	98	54	3	16783635
Pubmed	Expression of Sox transcription factors in the developing mouse pancreas.	SOX5 SOX13	4.88e-04	21	54	2	12815626
Pubmed	The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.	SOX5 SOX13	4.88e-04	21	54	2	16306355
Pubmed	The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex.	TRAF4 MNAT1	4.88e-04	21	54	2	25590999
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX5 HOXD11 PATZ1 BACH1 NFXL1 DMRTA2 SOX13	4.92e-04	908	54	7	19274049
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	POLR1A WDR6 SMCHD1 RPF2 UTP20 TASOR2	5.14e-04	653	54	6	22586326
Pubmed	Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes.	POLR1A MNAT1	5.36e-04	22	54	2	9582279
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	CACNA1S TNRC18 TULP4 UNK TASOR2	5.42e-04	430	54	5	35044719
Pubmed	Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.	POLR1A MNAT1	5.86e-04	23	54	2	12393749
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	BRD2 ZSCAN5A PATZ1 SMCHD1 BACH1 NFXL1 UTP20 INO80D	8.16e-04	1294	54	8	30804502
Pubmed	Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders.	SOX5 SOX13	8.72e-04	28	54	2	29365100
Pubmed	Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency	POLR3B IL17RD	8.72e-04	28	54	2	20301509
Pubmed	JAWS coordinates chondrogenesis and synovial joint positioning.	SOX5 HOXD11	9.35e-04	29	54	2	18539921
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	ZNF536 TNRC18 PATZ1 KNL1	9.73e-04	282	54	4	23667531
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TNRC18 TULP4 PLEKHG3 LRRCC1 EIF2AK1	1.00e-03	493	54	5	15368895
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	BRD2 ZSCAN5A SMCHD1 INO80D KNL1	1.02e-03	495	54	5	27705803
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	BRD2 SMCHD1 SOX13	1.05e-03	128	54	3	23858473
Pubmed	Expansion of the piriform cortex contributes to corticothalamic pathfinding defects in Gli3 conditional mutants.	SOX5 DMRTA2	1.07e-03	31	54	2	24014668
Pubmed	NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance.	ZSCAN5DP ZSCAN5A	1.14e-03	32	54	2	38060382
Pubmed	Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development.	HOXD11 CGA	1.21e-03	33	54	2	10049363
Pubmed	Human transcription factor protein interaction networks.	SOX5 ZNF536 BRD2 HOXD11 SMCHD1 UNK INO80D SOX13	1.54e-03	1429	54	8	35140242
GeneFamily	SRY-boxes	SOX5 SOX13	7.19e-04	19	38	2	757
GeneFamily	RNA polymerase subunits	POLR3B POLR1A	1.68e-03	29	38	2	726
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX5 CACNA1S WNT16 RPF2 NFXL1	1.51e-06	161	54	5	249c2b97cc25de5053f5048ee354615df49b2081
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-6\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SOX5 TRAF4 WNT16 DNAH8 KNL1	3.77e-06	194	54	5	2b5eee7c3e52b63cce94205d18133c7704329c02
ToppCell	mild_COVID-19_(asymptomatic)-B_intermediate\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	SOX5 TRAF4 DNAH8 KNL1	4.89e-05	166	54	4	8de8f388f24436b84e19ef460476fdbda4d16abf
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SOX5 CACNA1S ZNF536 WNT16	5.01e-05	167	54	4	3c3e1c31aacca48099693aea2efdfa22fc0e4af4
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Zbtb32+_B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SOX5 CACNA1S ZNF536 WNT16	5.01e-05	167	54	4	77a4d7ce44847c76074d4f5340d61b398fe43e6c
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_memory-B_memory-6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SOX5 TRAF4 DNAH8 KNL1	6.01e-05	175	54	4	1b3510e9078eec7cfc5805043e435e9e5e0f0877
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-FCRL4+_Memory_B\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SOX5 FBXO43 MUC16 DNAH8	6.70e-05	180	54	4	eedb6d89680f968167afb1dcd132c9de9096b50f
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PPARGC1A ZNF536 WNT16 BACH1	7.00e-05	182	54	4	a3c5c0eff527c8d3848acda14af8f9e99c69b0de
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PPARGC1A ZNF536 WNT16 BACH1	7.61e-05	186	54	4	6379609b7ace80683f5754b16aa77f11b43766ae
ToppCell	Healthy_donor-B_memory\|World / disease group, cell group and cell class (v2)	SOX5 TRAF4 MUC16 DNAH8	7.77e-05	187	54	4	4f68e3243071a4549c80aff8bff32c6ad892ee7f
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SOX5 TRAF4 DNAH8 KNL1	7.93e-05	188	54	4	18d16e3f095a109b6a690f46fe7fcd5674c3636b
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PPARGC1A ZNF536 WNT16 BACH1	7.93e-05	188	54	4	8de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PPARGC1A ZNF536 WNT16 BACH1	8.26e-05	190	54	4	8c9c230a509afaeee50644153974a5642b01a2b8
ToppCell	COPD-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	TULP4 CGA BACH1 DNAH8	8.43e-05	191	54	4	3ae18bc4e3dff49b5d5958da8ebc3f747274b69c
ToppCell	moderate-Lymphoid-B_cell\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SOX5 TRAF4 BACH1 DNAH8	8.60e-05	192	54	4	ae3727503c3b9f4695e565fd3161cc33b898f349
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SOX5 TRAF4 WNT16 DNAH8	8.78e-05	193	54	4	7cc10e8b51091869d46e462f3214999e7b5348b1
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PPARGC1A ZNF536 WNT16 BACH1	8.78e-05	193	54	4	c4b22b62f3cc7bf0ec0eba76e1504c236290bbc9
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SOX5 TRAF4 WNT16 DNAH8	8.95e-05	194	54	4	2b61023a602d336ed0de174e9141046173db34e6
ToppCell	COVID-19_Mild-Lymphoid_B-B_intermediate\|COVID-19_Mild / Disease group, lineage and cell class	SOX5 TRAF4 WNT16 DNAH8	8.95e-05	194	54	4	bf6f72a489c62cbf1a679552d8c5eaaaa0b99d33
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SOX5 TRAF4 WNT16 DNAH8	8.95e-05	194	54	4	f2486b19ac52a48d19f80b38a5536bee3dad745b
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-B-B_intermediate\|COVID-19_Mild / Disease, condition lineage and cell class	SOX5 TRAF4 WNT16 DNAH8	9.88e-05	199	54	4	1c6a08d01f6c1a2a4b6587d3a4522efbd03275e1
ToppCell	mild-B_intermediate\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TRAF4 SMCHD1 WNT16 DNAH8	1.01e-04	200	54	4	fe815824e9e4be3f3db73610e3814a7fd533da65
Disease	Alzheimer's disease (implicated_via_orthology)	SOX5 PPARGC1A TM2D2 SOX13	3.41e-06	57	53	4	DOID:10652 (implicated_via_orthology)
Disease	heart disease (implicated_via_orthology)	SOX5 PPARGC1A SOX13	4.42e-05	38	53	3	DOID:114 (implicated_via_orthology)
Disease	Idiopathic hypogonadotropic hypogonadism	POLR3B IL17RD	4.75e-04	18	53	2	C0342384
Disease	eye color	SOX5 TULP4 MUC16	5.76e-04	90	53	3	EFO_0003949
Disease	response to mTOR inhibitor	BACH1 STPG2	9.25e-04	25	53	2	EFO_0005417
Disease	QRS-T angle	SOX5 BACH1 MMP15	9.26e-04	106	53	3	EFO_0020097
Disease	prostate carcinoma	POLR1A ATP9B MNAT1 INO80D SOX13 TASOR2 KNL1	1.03e-03	891	53	7	EFO_0001663
Disease	response to aromatase inhibitor	GALNT17 MUC16	1.52e-03	32	53	2	GO_0061477
Disease	melanoma (is_marker_for)	PPARGC1A BRD2	1.61e-03	33	53	2	DOID:1909 (is_marker_for)
Disease	essential tremor	PPARGC1A TRAF4 LRRCC1	1.90e-03	136	53	3	EFO_0003108
Disease	hemorrhoid	SOX5 HOXD11 BACH1	2.36e-03	147	53	3	EFO_0009552
Disease	aortic stenosis, aortic valve calcification	DENND4C STPG2	2.60e-03	42	53	2	EFO_0000266, EFO_0005239

Protein segments in the cluster

Peptide	Gene	Start	Entry
AALALPSLCPKYRKF	BACH1	216	O14867
RYRKCIKLKQVQSPP	ADAM7	691	Q9H2U9
NLIYKLLKPSTKPRR	B3GALT1	186	Q9Y5Z6
CSYRKKKRPNVEEPL	ACVR1C	141	Q8NER5
CDPSRIYKPQTRLKR	DFFB	316	O76075
LLLRAAEKYPRTPKC	DMRTA2	56	Q96SC8
LECISKKAAPRRLYP	RAD9B	311	Q6WBX8
PLYSGCRLTLLRPKK	MUC16	13526	Q8WXI7
RLRPRPKVFLCYSSK	IL17RD	351	Q8NFM7
CPRCKTTKYRNPSLK	MNAT1	6	P51948
TTTCYCKKAKPIPRR	NFXL1	286	Q6ZNB6
KYLRRKLSPPSYCKL	ATP9B	1131	O43861
RKGAPRVLLYCKRSL	MMP15	651	P51511
PYLQRKLLKHTKCPR	NXF5	306	Q9H1B4
KLYVCPIYKKPRRTD	DNAH8	4446	Q96JB1
LPPKTVFKDKVRRCS	KNL1	1661	Q8NG31
DYYRCKITPSARKPL	NPIPA2	216	E9PIF3
CFSRAYPTPLRSKKT	CGA	56	P01215
KPQRRPCSELLKYLT	PPARGC1A	201	Q9UBK2
KPYSCPVCGLRFKRK	PATZ1	381	Q9HBE1
PAKYQPYKKRGLCSR	FBXO43	646	Q4G163
PESLRKRCPVQAKYI	EIF2AK1	546	Q9BQI3
YALKARPLRCYIPKN	CACNA1S	1091	Q13698
VAPQRSRKKRCPYTK	HOXD11	261	P31277
FLCYKRGRDKPPLTD	DENND4C	86	Q5VZ89
DRSIPDYRPTKCKEL	GALNT17	131	Q6IS24
PLCSYSPKLCKQRRL	INO80D	16	Q53TQ3
IIKLFRYPCLRKGAK	EML5	541	Q05BV3
CLKPKFPFLSIRRSA	AK9	1821	Q5TCS8
YSPRNPLKRTCIFKF	UTP20	2636	O75691
SRRKYQKKAAACPDP	POLR1A	1131	O95602
ELKKKPRRSCTLPNY	SMCHD1	1701	A6NHR9
YPNRYRCSPERLKKA	PLEKHG3	416	A1L390
RRRYSKKTACVLPAP	NPY5R	286	Q15761
RSYKLLLKKSGCRTP	RPF2	196	Q9H7B2
RYVLSCLRKKPRKPY	BRD2	701	P25440
KKTFLPPLCRAFACR	COA8	21	Q96IL0
KPATSRKQPFCLLLR	TNRC18	1791	O15417
VPKSEKEKPVCRRRY	TULP4	26	Q9NRJ4
YKYKPRPKRTCIVEG	SOX13	491	Q9UN79
SPRTFLRENKPCIKY	TM2D2	131	Q9BX73
EKPYKCPKCLRAFRR	ZSCAN5DP	461	P0CG00
RKSCPIPLFVKASKR	STPG2	411	Q8N412
KPYKCSKCPRAFSRL	ZSCAN5A	466	Q9BUG6
PLNSRQKELCKRKPY	WNT16	51	Q9UBV4
RLCRPYIIVKKQKPA	POLR3B	591	Q9NW08
YKFLEKPKRRLLCPL	TRAF4	6	Q9BUZ4
IFVKERCRYLLPPSK	WDR6	476	Q9NNW5
NILKTLVKSCRPYFP	PSME4	171	Q14997
KNRKYPCPLCGKRFR	ZNF536	126	O15090
PDYKYKPRPKRTCLV	SOX5	621	P35711
SKKVNLCRPFPKRTA	TASOR2	361	Q5VWN6
YKTEPCKKPPRLCRQ	UNK	216	Q9C0B0
KECNRKVPRRSKIPY	LRRCC1	341	Q9C099