Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	regulation of kidney development	PPP3CA SIX4 SIX1 SIX2	2.65e-05	38	94	4	GO:0090183
GeneOntologyBiologicalProcess	ectodermal placode morphogenesis	GNAS SIX4 SIX1	4.92e-05	16	94	3	GO:0071697
GeneOntologyBiologicalProcess	ectodermal placode formation	GNAS SIX4 SIX1	4.92e-05	16	94	3	GO:0060788
GeneOntologyBiologicalProcess	kidney mesenchyme development	SIX4 SIX1 SIX2	4.92e-05	16	94	3	GO:0072074
GeneOntologyBiologicalProcess	regulation of branch elongation involved in ureteric bud branching	SIX4 SIX1	6.15e-05	3	94	2	GO:0072095
GeneOntologyBiologicalProcess	ectodermal placode development	GNAS SIX4 SIX1	7.12e-05	18	94	3	GO:0071696
GeneOntologyBiologicalProcess	embryonic cranial skeleton morphogenesis	GNAS SIX4 SIX1 SIX2	9.26e-05	52	94	4	GO:0048701
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	MPL DOCK1 DOCK5 AGO1 PNPLA6 CLASP1 LOXL2 LPA FAT3 WNT16 ACTN1 GNAS SIX4 SIX1 SLC44A4 YJEFN3 ATP2B4 SIX2	1.12e-04	1483	94	18	GO:0048646
GeneOntologyBiologicalProcess	positive regulation of ureteric bud formation	SIX4 SIX1	1.23e-04	4	94	2	GO:0072107
GeneOntologyBiologicalProcess	regulation of ureteric bud formation	SIX4 SIX1	1.23e-04	4	94	2	GO:0072106
GeneOntologyBiologicalProcess	myotome development	SIX4 SIX1	1.23e-04	4	94	2	GO:0061055
GeneOntologyBiologicalProcess	branch elongation involved in ureteric bud branching	SIX4 SIX1	1.23e-04	4	94	2	GO:0060681
GeneOntologyBiologicalProcess	regulation of branching involved in ureteric bud morphogenesis	SIX4 SIX1 SIX2	1.73e-04	24	94	3	GO:0090189
GeneOntologyBiologicalProcess	adenylate cyclase-activating adrenergic receptor signaling pathway	GNAS RAPGEF2 ATP2B4	1.96e-04	25	94	3	GO:0071880
GeneOntologyBiologicalProcess	olfactory placode morphogenesis	SIX4 SIX1	2.04e-04	5	94	2	GO:0071699
GeneOntologyBiologicalProcess	olfactory placode development	SIX4 SIX1	2.04e-04	5	94	2	GO:0071698
GeneOntologyBiologicalProcess	trigeminal ganglion development	SIX4 SIX1	2.04e-04	5	94	2	GO:0061551
GeneOntologyBiologicalProcess	regulation of mesonephros development	SIX4 SIX1	2.04e-04	5	94	2	GO:0061217
GeneOntologyBiologicalProcess	olfactory placode formation	SIX4 SIX1	2.04e-04	5	94	2	GO:0030910
GeneOntologyBiologicalProcess	cranial ganglion development	SIX4 SIX1	3.05e-04	6	94	2	GO:0061550
GeneOntologyBiologicalProcess	fungiform papilla morphogenesis	SIX4 SIX1	3.05e-04	6	94	2	GO:0061197
GeneOntologyBiologicalProcess	nuclear-transcribed mRNA catabolic process	CASC3 AGO1 SMG7 THRAP3 SMG6	3.46e-04	132	94	5	GO:0000956
GeneOntologyBiologicalProcess	mRNA export from nucleus	CASC3 SMG7 YTHDC1 SMG6	3.65e-04	74	94	4	GO:0006406
GeneOntologyBiologicalProcess	ureteric bud formation	SIX4 SIX1	4.25e-04	7	94	2	GO:0060676
GeneOntologyBiologicalProcess	fungiform papilla development	SIX4 SIX1	4.25e-04	7	94	2	GO:0061196
GeneOntologyBiologicalProcess	regulation of synaptic assembly at neuromuscular junction	SIX4 SIX1	4.25e-04	7	94	2	GO:0008582
GeneOntologyBiologicalProcess	very long-chain fatty acid metabolic process	ACSL6 TECR ABCD3	5.40e-04	35	94	3	GO:0000038
GeneOntologyBiologicalProcess	adrenergic receptor signaling pathway	GNAS RAPGEF2 ATP2B4	5.40e-04	35	94	3	GO:0071875
GeneOntologyBiologicalProcess	ureteric bud elongation	SIX4 SIX1	5.65e-04	8	94	2	GO:0060677
GeneOntologyBiologicalProcess	cranial skeletal system development	GNAS SIX4 SIX1 SIX2	5.91e-04	84	94	4	GO:1904888
GeneOntologyCellularComponent	exon-exon junction complex	CASC3 THRAP3 SMG6	1.14e-04	21	95	3	GO:0035145
HumanPheno	Dilatation of renal calices	KMT2A SIX5 SIX1	8.83e-06	6	40	3	HP:0100581
HumanPheno	Abnormal renal calyx morphology	KMT2A SIX5 SIX1	8.83e-06	6	40	3	HP:0011130
Domain	SIX1_SD	SIX5 SIX4 SIX1 SIX2 SIX6	6.38e-11	7	95	5	IPR031701
Domain	SIX1_SD	SIX5 SIX4 SIX1 SIX2 SIX6	6.38e-11	7	95	5	PF16878
Domain	EST1	SMG7 SMG6	7.65e-05	3	95	2	PF10374
Domain	EST1_DNA_bind	SMG7 SMG6	7.65e-05	3	95	2	PF10373
Domain	EST1	SMG7 SMG6	7.65e-05	3	95	2	IPR019458
Domain	DNA/RNA-bd_Est1-type	SMG7 SMG6	7.65e-05	3	95	2	IPR018834
Domain	CABIT	THEMIS2 THEMIS	1.53e-04	4	95	2	PF12736
Domain	CABIT_dom	THEMIS2 THEMIS	1.53e-04	4	95	2	IPR025946
Domain	DOCK_N	DOCK1 DOCK5	2.53e-04	5	95	2	PF16172
Domain	DOCK_N	DOCK1 DOCK5	2.53e-04	5	95	2	IPR032376
Domain	Mob1_phocein	MOB3B MOB3A	5.29e-04	7	95	2	PF03637
Domain	MOB_kinase_act_fam	MOB3B MOB3A	5.29e-04	7	95	2	IPR005301
Domain	-	MOB3B MOB3A	5.29e-04	7	95	2	1.20.140.30
Domain	Mob1_phocein	MOB3B MOB3A	5.29e-04	7	95	2	SM01388
Domain	TCEAL1	TCEAL7 TCEAL6	9.00e-04	9	95	2	IPR010370
Domain	DHR-1_domain	DOCK1 DOCK5	1.37e-03	11	95	2	IPR027007
Domain	DHR_2	DOCK1 DOCK5	1.37e-03	11	95	2	PS51651
Domain	DHR_1	DOCK1 DOCK5	1.37e-03	11	95	2	PS51650
Domain	DHR-2	DOCK1 DOCK5	1.37e-03	11	95	2	PF06920
Domain	DOCK	DOCK1 DOCK5	1.37e-03	11	95	2	IPR026791
Domain	DOCK_C	DOCK1 DOCK5	1.37e-03	11	95	2	IPR010703
Domain	DOCK-C2	DOCK1 DOCK5	1.37e-03	11	95	2	PF14429
Domain	DHR-2	DOCK1 DOCK5	1.37e-03	11	95	2	IPR027357
Domain	BEX	TCEAL7 TCEAL6	2.24e-03	14	95	2	PF04538
Domain	TF_A-like/BEX	TCEAL7 TCEAL6	2.24e-03	14	95	2	IPR021156
Domain	Ferritin-like_SF	MOB3B MOB3A	2.24e-03	14	95	2	IPR009078
Domain	SMAD_FHA_domain	IRF5 KIF13A FOXK1	2.35e-03	52	95	3	IPR008984
Domain	AT_hook	KMT2A PHF21A	2.93e-03	16	95	2	PF02178
Domain	Acyl_Trfase/lysoPLipase	PNPLA6 PLA2G4A	3.31e-03	17	95	2	IPR016035
Domain	-	SMG7 ASPH TRAPPC8 GPSM1 SMG6	4.12e-03	207	95	5	1.25.40.10
Domain	RasGEFN	RAPGEF2 SOS2	4.58e-03	20	95	2	SM00229
Domain	RasGEF_N	RAPGEF2 SOS2	5.05e-03	21	95	2	PF00618
Domain	Cupredoxin	CP PADI1	5.53e-03	22	95	2	IPR008972
Domain	Ras-like_Gua-exchang_fac_N	RAPGEF2 SOS2	5.53e-03	22	95	2	IPR000651
Domain	RASGEF_NTER	RAPGEF2 SOS2	5.53e-03	22	95	2	PS50212
Pathway	KEGG_MEDICUS_VARIANT_MLL_ENL_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION	KMT2A SIX4 SIX1	4.31e-05	13	77	3	M47440
Pubmed	Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis.	SIX5 SIX4 SIX1 SIX2 SIX6	8.63e-13	6	96	5	20074369
Pubmed	The expression profile and clinic significance of the SIX family in non-small cell lung cancer.	SIX5 SIX4 SIX1 SIX2 SIX6	8.63e-13	6	96	5	27821176
Pubmed	Dynamic expression of Six family genes in the dental mesenchyme and the epithelial ameloblast stem/progenitor cells during murine tooth development.	SIX5 SIX4 SIX1 SIX2 SIX6	8.63e-13	6	96	5	19900183
Pubmed	Pleiotropic effects in Eya3 knockout mice.	SIX5 SIX4 SIX1 SIX2 SIX6	1.80e-11	9	96	5	19102749
Pubmed	Six family genes control the proliferation and differentiation of muscle satellite cells.	SIX5 SIX4 SIX1 SIX2	5.45e-11	4	96	4	20696153
Pubmed	Tissue and developmental distribution of Six family gene products.	SIX5 SIX4 SIX1 SIX2	2.72e-10	5	96	4	9551859
Pubmed	Identification and expression of six family genes in mouse retina.	SIX5 SIX4 SIX1 SIX2	2.72e-10	5	96	4	8814301
Pubmed	Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders.	SIX4 SIX1 SIX2 SIX6	2.72e-10	5	96	4	26034287
Pubmed	Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.	SIX5 SIX4 SIX1 SIX2	8.14e-10	6	96	4	9826681
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DHX16 PNPLA6 INCENP UTP15 NOP53 TECR ASPH MRPS23 ABCD3 ACTN1 TFB2M GNAS YTHDC1 DDX41 SPEN THRAP3 AQR STT3A RPL15	1.40e-09	1257	96	19	36526897
Pubmed	Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.	SIX5 SIX4 SIX1 SIX2	1.90e-09	7	96	4	12215533
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DHX16 PNPLA6 CLASP1 ESRRA ASPH KMT2A PLA2G4A PLCB3 PARD3 KAT6B YTHDC1 DDX41 SPEN THRAP3 CLASRP	3.50e-09	774	96	15	15302935
Pubmed	Six3 and Six6 activity is modulated by members of the groucho family.	SIX4 SIX1 SIX2 SIX6	3.78e-09	8	96	4	12441302
Pubmed	Impaired interactions between mouse Eyal harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach, and G proteins.	SIX5 SIX4 SIX1 SIX2	3.78e-09	8	96	4	11950062
Pubmed	Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme.	SIX5 SIX4 SIX1 SIX2	3.78e-09	8	96	4	15634706
Pubmed	Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development.	SIX5 SIX4 SIX1 SIX2	3.78e-09	8	96	4	11313460
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CASC3 PNPLA6 CLASP1 UTP15 NOP53 ASPH RBM26 MRPS23 ABCD3 KMT2A ACTN1 TFB2M SIX4 PARD3 YTHDC1 SPEN PLEKHA7 FOXK1 AQR SMG6	3.99e-09	1497	96	20	31527615
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	BUD23 DHX16 CASC3 AGO1 UTP15 NOP53 RBM26 MRPS23 TFB2M YTHDC1 DDX41 SPEN THRAP3 AQR RPL15	6.12e-09	807	96	15	22681889
Pubmed	Dachshund homologues play a conserved role in islet cell development.	SIX5 SIX4 SIX1 SIX2 SIX6	1.11e-08	27	96	5	20869363
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	DHX16 PHKA2 RBL1 RBM26 PLA2G4A SIX5 SIX4 SIX1 YTHDC1 SPEN RFX3 THRAP3 FOXK1 PARS2 PHF21A	1.36e-08	857	96	15	25609649
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DHX16 TCEAL7 AGO1 CLASP1 TECR MRPS23 ABCD3 USP12 YTHDC1 DDX41 SPEN THRAP3 AQR PARS2 STT3A RPL15	4.43e-08	1082	96	16	38697112
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	DOCK1 MOK AGO1 CLASP1 USP12 WDFY3 PARD3 KAT6B YTHDC1 PHF21A SMG6	2.85e-07	536	96	11	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	DOCK1 MOK AGO1 CLASP1 USP12 WDFY3 PARD3 KAT6B YTHDC1 PHF21A SMG6	2.96e-07	538	96	11	10512203
Pubmed	Overlapping functions of SIX homeoproteins during embryonic myogenesis.	SIX5 SIX4 SIX1 SIX2	5.55e-07	24	96	4	37267426
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	PNPLA6 NOP53 TECR ESRRA ASPH MRPS23 MUS81 KMT2A YTHDC1 THRAP3 AQR STT3A RPL15	6.07e-07	847	96	13	35850772
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DOCK1 DOCK5 CASC3 PPP3CA PNPLA6 SMG7 LOXL2 ASPH GNAS RAPGEF2 PARD3 KAT6B YJEFN3 THRAP3 STT3A SMG6 SOS2	6.29e-07	1489	96	17	28611215
Pubmed	Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base.	SIX4 SIX1 SIX2	7.08e-07	7	96	3	20515681
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CASC3 CLASP1 TESK2 KMT2A FSD1 GNAS RAPGEF2 PARD3 KIF13A DDX41 PLEKHA7 FOXK1 AQR	7.29e-07	861	96	13	36931259
Pubmed	Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human omphalocele.	SIX5 SIX4 SIX1	1.13e-06	8	96	3	30237319
Pubmed	Human transcription factor protein interaction networks.	BUD23 AGO1 SMG7 NOP53 TECR MRPS23 ABCD3 USP12 KMT2A SIX5 IRF5 SIX4 SPEN FOXK1 PHF21A STT3A	1.81e-06	1429	96	16	35140242
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ACSL6 PPP3CA AGO1 PNPLA6 CLASP1 TECR FKBP9 ABCD3 KMT2A ACTN1 RAPGEF2 YJEFN3 PLEKHA7 ATP2B4 THRAP3 RPL15	1.84e-06	1431	96	16	37142655
Pubmed	Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis.	SIX4 SIX1 SIX2	2.41e-06	10	96	3	16938278
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	DOCK5 TECR ASPH MUS81 KMT2A SIX4 YTHDC1 DDX41 SPEN THRAP3 SIX2 FOXK1 PHF21A CLASRP RPL15	2.59e-06	1294	96	15	30804502
Pubmed	Homeobox genes and connective tissue patterning.	SIX1 SIX2 SOS2	3.31e-06	11	96	3	7720577
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	DOCK5 LMAN1 CLASP1 RBL1 TESK2 ABCD3 ACTN1 TFB2M PARD3 DDX41 PLEKHA7 RFX3 FOXK1 PHF21A CLASRP	3.33e-06	1321	96	15	27173435
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ESRRA KMT2A SIX5 IRF5 SIX4 SIX1 KAT6B SIX2 FOXK1 PHF21A SIX6	4.29e-06	709	96	11	22988430
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	BUD23 DHX16 PNPLA6 INCENP UTP15 ASPH MRPS23 ABCD3 ACTN1 WDFY3 PARD3 DDX41 THRAP3 AQR RPL15	4.45e-06	1353	96	15	29467282
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	CASC3 TECR ASPH RBM26 MRPS23 YTHDC1 DDX41 THRAP3 AQR CLASRP RPL15	4.53e-06	713	96	11	29802200
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	RBM26 KMT2A KAT6B DDX41 SPEN THRAP3 FOXK1 AQR	4.93e-06	341	96	8	32971831
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	BUD23 DHX16 CASC3 CLASP1 TECR ASPH RBM26 USP12 KMT2A GNAS PARD3 DDX41 ATP2B4 THRAP3 RPL15	5.22e-06	1371	96	15	36244648
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	FAM234A AGPAT5 LMAN1 CLASP1 TECR ASPH ABCD3 ACTN1 GNAS YTHDC1 THRAP3 AQR STT3A RPL15	5.54e-06	1203	96	14	29180619
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	DHX16 CASC3 FBXW10 SMG7 CLASP1 UTP15 RBM26 GNAS RAPGEF2 GPSM1 THRAP3 FOXK1 CLASRP	5.66e-06	1038	96	13	26673895
Pubmed	DNA-binding and regulation mechanisms of the SIX family of retinal determination proteins.	SIX2 SIX6	7.54e-06	2	96	2	18293925
Pubmed	Association of three single nucleotide polymorphisms at the SIX1-SIX6 locus with primary open angle glaucoma in the Chinese population.	SIX1 SIX6	7.54e-06	2	96	2	27260188
Pubmed	Association of SIX1-SIX6 polymorphisms with peripapillary retinal nerve fibre layer thickness in children.	SIX1 SIX6	7.54e-06	2	96	2	35017159
Pubmed	Association of SIX1/SIX6 locus polymorphisms with regional circumpapillary retinal nerve fibre layer thickness: The Nagahama study.	SIX1 SIX6	7.54e-06	2	96	2	28663559
Pubmed	Age-dependent regional retinal nerve fibre changes in SIX1/SIX6 polymorphism.	SIX1 SIX6	7.54e-06	2	96	2	32719476
Pubmed	Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse.	SIX1 SIX2	7.54e-06	2	96	2	33281191
Pubmed	Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates.	SMG7 SMG6	7.54e-06	2	96	2	28461625
Pubmed	Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies.	SIX4 SIX6	7.54e-06	2	96	2	10512683
Pubmed	Lack of association between SIX1/SIX6 locus polymorphisms and pseudoexfoliation syndrome in a population from the Republic of Korea.	SIX1 SIX6	7.54e-06	2	96	2	36596020
Pubmed	Association of Polymorphisms at the SIX1/SIX6 Locus With Normal Tension Glaucoma in a Korean Population.	SIX1 SIX6	7.54e-06	2	96	2	35658088
Pubmed	Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways.	SMG7 SMG6	7.54e-06	2	96	2	27864472
Pubmed	Association of Polymorphisms at the SIX1-SIX6 Locus With Primary Open-Angle Glaucoma.	SIX1 SIX6	7.54e-06	2	96	2	31284308
Pubmed	The sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit.	PPP3CA ATP2B4	7.54e-06	2	96	2	15955804
Pubmed	Polymorphism rs10483727 in the SIX1/SIX6 Gene Locus Is a Risk Factor for Primary Open Angle Glaucoma in a Saudi Cohort.	SIX1 SIX6	7.54e-06	2	96	2	29190129
Pubmed	Cooperation between myogenic regulatory factors and SIX family transcription factors is important for myoblast differentiation.	SIX4 SIX1	7.54e-06	2	96	2	20601407
Pubmed	Expression of three zebrafish Six4 genes in the cranial sensory placodes and the developing somites.	SIX5 SIX4	7.54e-06	2	96	2	11044620
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DHX16 LMAN1 INCENP UTP15 NOP53 RBM26 ABCD3 GNAS DDX41 SPEN PLEKHA7 THRAP3 AQR STT3A RPL15	8.28e-06	1425	96	15	30948266
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PNPLA6 SMG7 RBL1 FAT3 ESRRA WDFY3 RAPGEF2 PARD3 KAT6B DDX41 FOXK1 PARS2 PHF21A	1.22e-05	1116	96	13	31753913
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	BUD23 DHX16 PPP3CA LMAN1 INCENP NOP53 LOXL2 TECR ASPH FKBP9 MRPS23 GNAS AQR STT3A	1.29e-05	1297	96	14	33545068
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	DHX16 CASC3 AGPAT5 LMAN1 UTP15 TECR ABCD3 KMT2A YTHDC1 DDX41 THRAP3 AQR STT3A RPL15	1.55e-05	1318	96	14	30463901
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	LMAN1 CLASP1 TECR ASPH RBM26 ABCD3 GNAS SIX4 SIX1 GPSM1 FOXK1 STT3A	1.57e-05	974	96	12	28675297
Pubmed	Six1 is required for signaling center formation and labial-lingual asymmetry in developing lower incisors.	SIX4 SIX1 SIX2	1.61e-05	18	96	3	32243674
Pubmed	The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.	CASC3 SMG7 SMG6	1.61e-05	18	96	3	25220460
Pubmed	Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.	TCEAL7 LMAN1 INCENP MRPS23 AQR PARS2 SIX6	1.72e-05	292	96	7	12819125
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	BUD23 INCENP UTP15 NOP53 RBM26 ABCD3 ACTN1 NUDCD1 YTHDC1 DDX41 THRAP3 RPL15	1.82e-05	989	96	12	36424410
Pubmed	Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1.	SIX5 SIX1	2.26e-05	3	96	2	11978764
Pubmed	Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4.	SIX4 SIX1	2.26e-05	3	96	2	32826305
Pubmed	Mutation screening of the EYA1, SIX1, and SIX5 genes in an East Asian cohort with branchio-oto-renal syndrome.	SIX5 SIX1	2.26e-05	3	96	2	22447252
Pubmed	A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed.	SMG7 SMG6	2.26e-05	3	96	2	12676087
Pubmed	Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice.	SIX5 SIX4	2.26e-05	3	96	2	27224259
Pubmed	Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome.	SIX1 SIX2	2.26e-05	3	96	2	11734542
Pubmed	Branchiootorenal Spectrum Disorder	SIX5 SIX1	2.26e-05	3	96	2	20301554
Pubmed	Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss.	SIX1 SIX2	2.26e-05	3	96	2	15735644
Pubmed	MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis.	SIX4 SIX1	2.26e-05	3	96	2	27302134
Pubmed	Genetic association of SNPs near ATOH7, CARD10, CDKN2B, CDC7 and SIX1/SIX6 with the endophenotypes of primary open angle glaucoma in Indian population.	SIX1 SIX6	2.26e-05	3	96	2	25798827
Pubmed	Branchio-oto-renal syndrome: comprehensive review based on nationwide surveillance in Japan.	SIX5 SIX1	2.26e-05	3	96	2	24730701
Pubmed	Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation.	GNAS RAPGEF2	2.26e-05	3	96	2	12391161
Pubmed	WNT16b promotes the proliferation and self-renewal of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/NFATC2 pathway.	PPP3CA WNT16	2.26e-05	3	96	2	36974338
Pubmed	Mutation screening of the EYA1, SIX1, and SIX5 genes in a large cohort of patients harboring branchio-oto-renal syndrome calls into question the pathogenic role of SIX5 mutations.	SIX5 SIX1	2.26e-05	3	96	2	21280147
Pubmed	Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer.	SIX5 SIX4	2.26e-05	3	96	2	14966291
Pubmed	Phenotype-genotype correlation in patients with typical and atypical branchio-oto-renal syndrome.	SIX5 SIX1	2.26e-05	3	96	2	35046468
Pubmed	Branchiootorenal syndrome and oculoauriculovertebral spectrum features associated with duplication of SIX1, SIX6, and OTX2 resulting from a complex chromosomal rearrangement.	SIX1 SIX6	2.26e-05	3	96	2	18666230
Pubmed	SIX1 and SIX4 homeoproteins regulate PAX7+ progenitor cell properties during fetal epaxial myogenesis.	SIX5 SIX4 SIX1	2.61e-05	21	96	3	32591430
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	ACSL6 CLASP1 TECR ABCD3 USP12 ACTN1 RAPGEF2 PARD3	2.63e-05	430	96	8	32581705
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	PHKA2 INCENP KMT2A YTHDC1 DDX41 THRAP3	2.66e-05	210	96	6	16565220
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	DHX16 PNPLA6 ASPH ABCD3 KMT2A DDX41 PLEKHA7 THRAP3 RPL15	4.42e-05	601	96	9	33658012
Pubmed	Direct molecular regulation of the myogenic determination gene Myf5 by Pax3, with modulation by Six1/4 factors, is exemplified by the -111 kb-Myf5 enhancer.	SIX4 SIX1	4.51e-05	4	96	2	23384562
Pubmed	Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators.	SIX1 SIX2	4.51e-05	4	96	2	26884396
Pubmed	A VE-cadherin-PAR3-α-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A(2)α in endothelial cells.	PLA2G4A PARD3	4.51e-05	4	96	2	22398721
Pubmed	Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents.	PPP3CA ATP2B4	4.51e-05	4	96	2	19287093
Pubmed	DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV.	DOCK1 DOCK5	4.51e-05	4	96	2	19004829
Pubmed	G-protein-activated phospholipase C-beta, new partners for cell polarity proteins Par3 and Par6.	PLCB3 PARD3	4.51e-05	4	96	2	15782111
Pubmed	SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway.	SMG7 SMG6	4.51e-05	4	96	2	15721257
Pubmed	Induction of Galphas contributes to the paradoxical stimulation of cytosolic phospholipase A2alpha expression by cortisol in human amnion fibroblasts.	PLA2G4A GNAS	4.51e-05	4	96	2	20203101
Pubmed	Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.	SIX1 SIX2	4.51e-05	4	96	2	25670082
Pubmed	Functional conservation of the telomerase protein Est1p in humans.	SMG7 SMG6	4.51e-05	4	96	2	12699629
Pubmed	Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.	DOCK1 DOCK5	4.51e-05	4	96	2	23362269
Pubmed	The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo.	DOCK1 DOCK5	4.51e-05	4	96	2	18820033
Interaction	DHX8 interactions	DHX16 RBM26 USP12 NUDCD1 DDX41 SPEN THRAP3 AQR CLASRP RPL15	1.08e-06	292	94	10	int:DHX8
Interaction	MEN1 interactions	PNPLA6 NOP53 ESRRA ASPH RBM26 MUS81 KMT2A KAT6B YTHDC1 DDX41 SPEN THRAP3 FOXK1 AQR STT3A RPL15	2.04e-05	1029	94	16	int:MEN1
Interaction	SOX2 interactions	AGO1 UTP15 NOP53 TECR ASPH MRPS23 ABCD3 KMT2A CP SIX4 SIX1 KAT6B DDX41 SPEN RFX3 THRAP3 FOXK1 RPL15 SMG6	2.59e-05	1422	94	19	int:SOX2
Interaction	CIT interactions	DHX16 LMAN1 INCENP CLASP1 UTP15 NOP53 TECR ASPH ABCD3 KMT2A IRF5 ACTN1 TFB2M GNAS PARD3 DDX41 THRAP3 AQR RPL15	3.39e-05	1450	94	19	int:CIT
Interaction	FTL interactions	MOK AGPAT5 UTP15 NOP53 PSKH1 MUS81 FSD1 PLCB3 YTHDC1	3.61e-05	348	94	9	int:FTL
Interaction	LLGL2 interactions	DOCK1 CASC3 RBM26 NUDCD1 THRAP3 PHF21A	3.73e-05	133	94	6	int:LLGL2
Cytoband	Ensembl 112 genes in cytogenetic band chr1p34	MPL AGO1 TESK2 ZFP69B THRAP3	3.95e-04	294	96	5	chr1p34
Cytoband	1q25	SMG7 PLA2G4A	1.36e-03	26	96	2	1q25
Cytoband	11q13	ESRRA MUS81 PLCB3	1.99e-03	118	96	3	11q13
Cytoband	Ensembl 112 genes in cytogenetic band chr14q23	SIX4 SIX1 SIX6	2.62e-03	130	96	3	chr14q23
GeneFamily	SINE class homeoboxes	SIX5 SIX4 SIX1 SIX2 SIX6	2.61e-12	6	63	5	525
GeneFamily	MOB kinase activators\|STRIPAK complex	MOB3B MOB3A	2.48e-04	7	63	2	647
GeneFamily	Transcription elongation factor A like family	TCEAL7 TCEAL6	4.23e-04	9	63	2	1216
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLA2G4A PLCB3	1.97e-03	19	63	2	832
GeneFamily	PHD finger proteins	KMT2A KAT6B PHF21A	3.82e-03	90	63	3	88
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	DOCK1 MOK CLASP1 USP12 WDFY3 RAPGEF2 TRAPPC8 PARD3 KAT6B SPEN ATP2B4 AQR PHF21A SOS2	2.48e-06	856	95	14	M4500
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	MOK CLASP1 USP12 RAPGEF2 TRAPPC8 PARD3 KAT6B SPEN PHF21A	5.00e-05	466	95	9	M13522
Coexpression	GSE25088_IL4_VS_IL4_AND_ROSIGLITAZONE_STIM_STAT6_KO_MACROPHAGE_DAY10_UP	DOCK5 PHKA2 NLRP12 MOB3A ATP2B4 PHF21A	8.57e-05	198	95	6	M7944
Coexpression	GSE3982_NEUTROPHIL_VS_TH2_DN	LMAN1 NOP53 ABCD3 USP12 PLA2G4A THRAP3	8.57e-05	198	95	6	M5535
Coexpression	GSE17721_LPS_VS_CPG_0.5H_BMDC_UP	INCENP CLASP1 TESK2 THSD1 PARD3 SOS2	8.57e-05	198	95	6	M3982
Coexpression	GSE11864_UNTREATED_VS_CSF1_PAM3CYS_IN_MAC_DN	DOCK1 CASC3 LMAN1 SMG7 PSKH1 SLC44A4	8.57e-05	198	95	6	M3130
Coexpression	GSE17721_CTRL_VS_CPG_0.5H_BMDC_UP	DOCK5 CASC3 AGPAT5 INCENP THSD1 SOS2	8.81e-05	199	95	6	M3754
Coexpression	GSE30971_CTRL_VS_LPS_STIM_MACROPHAGE_WBP7_HET_4H_DN	PHKA2 AGO1 ABCD3 PLA2G4A NDUFC1 THRAP3	8.81e-05	199	95	6	M8707
Coexpression	GSE17721_0.5H_VS_12H_GARDIQUIMOD_BMDC_DN	RBL1 USP12 NUDCD1 RFX3 PHF21A SMG6	9.05e-05	200	95	6	M4136
Coexpression	GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP	NLRP12 NOP53 THSD1 DDX41 MOB3A SOS2	9.05e-05	200	95	6	M5772
Coexpression	ENK_UV_RESPONSE_EPIDERMIS_DN	PPP3CA CYP2J2 NOP53 TESK2 TECR ABCD3 KMT2A KAT6B SOS2	1.02e-04	512	95	9	M4508
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 CLASP1 WDFY3 RAPGEF2 PARD3 KIF13A PLEKHA7	2.46e-07	198	96	7	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AGPAT5 CYP2J2 FAT3 CP NUDCD1 SLC44A4	1.62e-06	166	96	6	60060b03f2abfa3cc08107ab5a9f578e60e4ae16
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AGPAT5 CYP2J2 FAT3 CP NUDCD1 SLC44A4	1.62e-06	166	96	6	ec9161d388db5a257b8d125c14f9dd911d5d5d4a
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AGPAT5 CYP2J2 FAT3 CP NUDCD1 SLC44A4	1.62e-06	166	96	6	4586d6725403f879fc96f67be579022587ce1906
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LMAN1 LOXL2 ASPH FKBP9 CP GNAS	3.76e-06	192	96	6	2dee0402e97e48157e0bc01bcc8034f1645dfb7b
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 CLASP1 USP25 WDFY3 RAPGEF2 PARD3	4.62e-06	199	96	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_B0\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	ACSL6 TCEAL7 THEMIS PRDM13 SIX4	1.23e-05	138	96	5	2709fb83dfe6c2e27050b08b678a6d6b25d47906
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-10\|TCGA-Brain / Sample_Type by Project: Shred V9	MPL CP SPATS1 PLEKHA7 PADI1	3.46e-05	171	96	5	74be8d3bf6b99e2d734635a8b1a7c41e8c596959
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PHKA2 INCENP TESK2 KIF13A SMG6	3.76e-05	174	96	5	a79ebb01a5849c314e02594a9c95009dbb03cb8c
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic_-_developing-thymocyte\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	THEMIS AGPAT5 ABCD3 ACTN1 PARD3	5.43e-05	188	96	5	bcfc426b60d8e5a23a2360bfb68b32868fec9fbf
ToppCell	facs-Lung-EPCAM-18m-Epithelial-Basal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL2 SIX4 SIX1 SIX2 PADI1	5.56e-05	189	96	5	783c1db856f2defe6f3b8748dd0bc29a8102f6d1
ToppCell	facs-Lung-EPCAM-18m-Epithelial-respiratory_basal_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL2 SIX4 SIX1 SIX2 PADI1	5.56e-05	189	96	5	88b72fafbe58463543e0818f27f3dd9e5b4d34d2
ToppCell	facs-Bladder-nan-3m-Epithelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM234A ASPH ABCD3 PARD3 RPL15	6.30e-05	194	96	5	e74cd8cf3763f6adbfd1c269a886a806049714cf
ToppCell	COVID-19-Epithelial-Club,_Basal_cells\|COVID-19 / Condition, Lineage and Cell class	CYP2J2 CP SIX1 SLC44A4 SIX2	6.61e-05	196	96	5	dd32046067d93b9484cfbf1d7826a436a3d9f0e9
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-ciliated_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CYP2J2 CP SIX1 SLC44A4 SIX2	6.61e-05	196	96	5	d9426eba69047166ffa8179f1654e011c1020328
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CYP2J2 CP SIX1 SLC44A4 SIX2	6.61e-05	196	96	5	7e19919eafd6ddf547dd4e8aa532a050e182c5cc
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	LMAN1 ASPH ABCD3 PLA2G4A CP	6.77e-05	197	96	5	1638959d7aecb9fc5285eb7e4a3103ca437989e2
ToppCell	proximal-Epithelial-Differentiating_Basal-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CYP2J2 CP SIX1 SLC44A4 SIX2	7.10e-05	199	96	5	c607346f60e5997e757e5a31cab412ab3734377b
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Club\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CYP2J2 CP SIX4 SIX1 SLC44A4	7.10e-05	199	96	5	2b17694cffbec28a2c8f165dfcff6bab94aa0f4c
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Club\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	CYP2J2 CP SIX4 SIX1 SLC44A4	7.10e-05	199	96	5	111cfd589ec6795075d8d88d7664bfb23eba5bf6
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Club-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CYP2J2 CP SIX4 SIX1 SLC44A4	7.10e-05	199	96	5	d583290a1d288b749ad17bc501c1487268c6551c
ToppCell	proximal-3-Epithelial-Differentiating_Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CYP2J2 CP SIX1 SLC44A4 SIX2	7.10e-05	199	96	5	12e07084fc2d5d4c418df564ccc0e132b056e549
ToppCell	proximal-Epithelial-Differentiating_Basal\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CYP2J2 CP SIX1 SLC44A4 SIX2	7.10e-05	199	96	5	96a89a2578fad9a99c52d2cf9e26e06516a96568
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LMAN1 LOXL2 FKBP9 ACTN1 GNAS	7.10e-05	199	96	5	cfe6f881a86607544e1413ef38e4b6797ef1a61c
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CYP2J2 CP SIX1 SLC44A4 SIX2	7.10e-05	199	96	5	a706ad5cd5e0dc8d7e925a05e45b07d35963f294
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LMAN1 LOXL2 FKBP9 CP ACTN1	7.27e-05	200	96	5	5a5d70bfb6d253f272cc1f8516205fcfe8106291
Drug	ICI182,780; Up 200; 1uM; PC3; HT_HG-U133A	DOCK1 SMG7 CYP2J2 MOB3B IRF5 FSD1 PLCB3 SIX2	1.74e-06	197	95	8	6867_UP
Drug	Cotinine (-) [486-56-6]; Down 200; 22.6uM; MCF7; HT_HG-U133A	PHKA2 LMAN1 SMG7 ASPH WDFY3 THSD1 SIX1 SOS2	1.81e-06	198	95	8	5246_DN
Drug	2-propylpentanoic acid; Up 200; 200uM; MCF7; HT_HG-U133A	DOCK5 PNPLA6 LMAN1 WNT16 WDFY3 RAPGEF2 PADI1 SOS2	1.88e-06	199	95	8	6974_UP
Drug	Neostigmine bromide [114-80-7]; Down 200; 13.2uM; PC3; HT_HG-U133A	LMAN1 RBL1 ASPH KMT2A RAPGEF2 KAT6B SPEN	1.40e-05	188	95	7	6735_DN
Drug	Acetaminophen [103-90-2]; Down 200; 26.4uM; MCF7; HT_HG-U133A	DOCK5 PNPLA6 SMG7 SIX1 KIF13A SIX2 SOS2	1.72e-05	194	95	7	5384_DN
Drug	Promazine hydrochloride [53-60-1]; Down 200; 12.4uM; PC3; HT_HG-U133A	DOCK5 INCENP RBL1 ASPH KMT2A THSD1 SPEN	1.72e-05	194	95	7	4308_DN
Drug	Ebselen [60940-34-3]; Down 200; 14.6uM; MCF7; HT_HG-U133A	SMG7 CYP2J2 PSKH1 ESRRA PLCB3 THSD1 SOS2	1.78e-05	195	95	7	3458_DN
Drug	Novobiocin sodium salt [1476-53-5]; Down 200; 6.4uM; MCF7; HT_HG-U133A	LMAN1 ASPH PLCB3 RAPGEF2 SIX1 PARD3 SOS2	1.83e-05	196	95	7	4392_DN
Drug	Pregnenolone [145-13-1]; Down 200; 12.6uM; MCF7; HT_HG-U133A	DOCK5 TESK2 ESRRA FSD1 ATP2B4 AQR SOS2	1.83e-05	196	95	7	2856_DN
Drug	Clioquinol [130-26-7]; Down 200; 13uM; PC3; HT_HG-U133A	INCENP RBM26 FSD1 WDFY3 RAPGEF2 SIX1 PADI1	1.83e-05	196	95	7	4663_DN
Drug	Trimethoprim [738-70-5]; Down 200; 13.8uM; MCF7; HT_HG-U133A	DOCK5 LMAN1 SMG7 ESRRA WDFY3 SIX1 PADI1	1.90e-05	197	95	7	2307_DN
Drug	(cis-) Nanophine [5072-45-7]; Down 200; 26.8uM; MCF7; HT_HG-U133A	DOCK5 LMAN1 LOXL2 ASPH RAPGEF2 SIX1 AQR	1.90e-05	197	95	7	3889_DN
Drug	Chenodiol [474-25-9]; Down 200; 10.2uM; MCF7; HT_HG-U133A	DOCK1 CASC3 AGO1 PNPLA6 ASPH PLCB3 SOS2	2.02e-05	199	95	7	7433_DN
Drug	Dosulepin hydrochloride [897-15-4]; Down 200; 12uM; PC3; HT_HG-U133A	LMAN1 PSKH1 ASPH KMT2A RAPGEF2 KAT6B SOS2	2.02e-05	199	95	7	7284_DN
Drug	propiconazole	CLASP1 FSD1 STT3A CLASRP	2.56e-05	41	95	4	CID000043234
Drug	L-anserine	NLRP12 TECR CP	3.79e-05	16	95	3	CID000011444
Drug	Infecundin	CP DDX41	5.15e-05	3	95	2	CID000066444
Drug	irinotecan HCl; Down 200; 100uM; PC3; HT_HG-U133A	USP12 RAPGEF2 PARD3 KAT6B PHF21A SOS2	8.22e-05	171	95	6	7535_DN
Drug	dpGp	PNPLA6 GNAS	1.03e-04	4	95	2	CID000129100
Drug	Pyrvinium pamoate [3546-41-6]; Down 200; 3.4uM; HL60; HT_HG-U133A	LMAN1 PRDM13 WDFY3 KAT6B AQR SOS2	1.12e-04	181	95	6	2957_DN
Drug	Thimerosal	THEMIS2 AGO1 NOP53 TECR FRMD7 RBM26 USP25 KMT2A SIX5 WDFY3 RAPGEF2 SPEN THRAP3 PHF21A SIX6	1.27e-04	1199	95	15	ctd:D013849
Drug	Phenformin hydrochloride [834-28-6]; Down 200; 16.6uM; PC3; HT_HG-U133A	SMG7 ASPH RAPGEF2 KAT6B SPEN SOS2	1.51e-04	191	95	6	4283_DN
Drug	Butacaine [149-16-6]; Down 200; 13uM; MCF7; HT_HG-U133A	MOK DOCK5 INCENP ESRRA PARD3 SOS2	1.55e-04	192	95	6	3469_DN
Drug	Anabasine [494-52-0]; Down 200; 24.6uM; MCF7; HT_HG-U133A	MOK RBL1 ASPH PLCB3 WDFY3 SOS2	1.64e-04	194	95	6	6774_DN
Drug	Nitrofurantoin [67-20-9]; Down 200; 16.8uM; PC3; HT_HG-U133A	ESRRA ACTN1 GNAS SIX2 PADI1 SOS2	1.64e-04	194	95	6	3674_DN
Drug	Fenofibrate [49562-28-9]; Down 200; 11uM; MCF7; HT_HG-U133A	DOCK1 PNPLA6 LMAN1 ASPH PLCB3 SOS2	1.69e-04	195	95	6	7432_DN
Drug	Xylazine [7361-61-7]; Down 200; 18.2uM; MCF7; HT_HG-U133A	LMAN1 ASPH MOB3B PLCB3 PARD3 SIX2	1.69e-04	195	95	6	4147_DN
Drug	Tetrandrine [518-34-3]; Down 200; 6.4uM; MCF7; HT_HG-U133A	PLCB3 THSD1 SIX1 PARD3 AQR SOS2	1.69e-04	195	95	6	6082_DN
Drug	Mephenytoin [50-12-4]; Down 200; 18.4uM; MCF7; HT_HG-U133A	DOCK1 LMAN1 WDFY3 RAPGEF2 SMG6 SOS2	1.69e-04	195	95	6	3580_DN
Drug	Sulfapyridine [144-83-2]; Down 200; 16uM; MCF7; HT_HG-U133A	KMT2A PLCB3 GNAS SIX1 KIF13A SOS2	1.69e-04	195	95	6	6101_DN
Drug	(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A	PHKA2 LMAN1 INCENP ESRRA WNT16 SMG6	1.69e-04	195	95	6	3893_DN
Drug	Oxybutynin chloride [1508-65-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A	DOCK1 LMAN1 SMG7 ASPH WDFY3 SOS2	1.69e-04	195	95	6	6770_DN
Drug	EDTA-chromium	LPA TECR	1.71e-04	5	95	2	CID000028282
Drug	Ethoxyquin [91-53-2]; Up 200; 18.4uM; PC3; HT_HG-U133A	DOCK1 LMAN1 LOXL2 ESRRA WNT16 KMT2A	1.74e-04	196	95	6	4321_UP
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Down 200; 9.6uM; PC3; HT_HG-U133A	DOCK1 SMG7 PLCB3 WDFY3 THSD1 SOS2	1.74e-04	196	95	6	5765_DN
Drug	Chlorpheniramine maleate [113-92-8]; Up 200; 10.2uM; MCF7; HT_HG-U133A	MOK LOXL2 WNT16 MOB3B KMT2A SOS2	1.74e-04	196	95	6	2217_UP
Drug	Methylprednisolone, 6-alpha [83-43-2]; Down 200; 10.6uM; MCF7; HT_HG-U133A	ESRRA IRF5 PLCB3 ZFP69B KAT6B PADI1	1.78e-04	197	95	6	6785_DN
Drug	Flurandrenolide [1524-88-5]; Down 200; 9.2uM; MCF7; HT_HG-U133A	ESRRA IRF5 THSD1 SIX1 KIF13A SOS2	1.78e-04	197	95	6	4702_DN
Drug	Alfuzosin hydrochloride [81403-68-1]; Down 200; 9.4uM; MCF7; HT_HG-U133A	PHKA2 SMG7 INCENP CLASP1 PARD3 SOS2	1.78e-04	197	95	6	5605_DN
Drug	Pralidoxime chloride [51-15-0]; Up 200; 23.2uM; MCF7; HT_HG-U133A	LMAN1 ESRRA PLCB3 GNAS PADI1 SMG6	1.78e-04	197	95	6	5383_UP
Drug	Neostigmine bromide [114-80-7]; Up 200; 13.2uM; MCF7; HT_HG-U133A	LMAN1 SMG7 INCENP ESRRA RAPGEF2 SIX2	1.78e-04	197	95	6	5335_UP
Drug	celecoxib; Down 200; 10uM; MCF7; HT_HG-U133A_EA	SMG7 INCENP RBL1 PSKH1 ESRRA WDFY3	1.78e-04	197	95	6	922_DN
Drug	Heliotrine [303-33-3]; Down 200; 12.8uM; MCF7; HT_HG-U133A	MOK ASPH MOB3B FSD1 SIX1 SOS2	1.78e-04	197	95	6	3615_DN
Drug	Panthenol (D) [81-13-0]; Up 200; 19.4uM; MCF7; HT_HG-U133A	LMAN1 INCENP WDFY3 PARD3 KAT6B ATP2B4	1.78e-04	197	95	6	1680_UP
Drug	Pridinol methanesulfonate salt [6856-31-1]; Down 200; 10.2uM; MCF7; HT_HG-U133A	DOCK1 ESRRA KMT2A FSD1 ACTN1 SOS2	1.78e-04	197	95	6	3456_DN
Drug	Eucatropine hydrochloride [536-93-6]; Down 200; 12.2uM; MCF7; HT_HG-U133A	LMAN1 INCENP KMT2A THSD1 PARD3 PADI1	1.78e-04	197	95	6	3935_DN
Drug	Demecarium bromide [56-94-0]; Up 200; 5.6uM; HL60; HG-U133A	DOCK5 PHKA2 ASPH RAPGEF2 KAT6B SOS2	1.78e-04	197	95	6	1781_UP
Drug	6-Furfurylaminopurine [525-79-1]; Down 200; 18.6uM; MCF7; HT_HG-U133A	DOCK5 ASPH WDFY3 GNAS THSD1 PARD3	1.83e-04	198	95	6	6073_DN
Drug	5211181; Down 200; 12uM; MCF7; HT_HG-U133A_EA	PNPLA6 RBL1 RAPGEF2 PARD3 KAT6B ATP2B4	1.83e-04	198	95	6	950_DN
Drug	Cotinine (-) [486-56-6]; Down 200; 22.6uM; MCF7; HT_HG-U133A	LMAN1 INCENP FSD1 WDFY3 PADI1 SOS2	1.83e-04	198	95	6	5611_DN
Drug	Clopamide [636-54-4]; Down 200; 11.6uM; PC3; HT_HG-U133A	PSKH1 ASPH RAPGEF2 SIX1 PARD3 SOS2	1.83e-04	198	95	6	6301_DN
Drug	(R)-Propranolol hydrochloride [13071-11-9]; Down 200; 13.6uM; MCF7; HT_HG-U133A	PHKA2 SMG7 INCENP RBL1 RAPGEF2 SIX1	1.83e-04	198	95	6	3553_DN
Drug	Tetrahydroalstonine [6474-90-4]; Up 200; 11.4uM; HL60; HG-U133A	LMAN1 INCENP TFB2M THSD1 DDX41 PADI1	1.83e-04	198	95	6	1756_UP
Drug	Tolazoline hydrochloride [59-97-2]; Down 200; 20.4uM; MCF7; HT_HG-U133A	PHKA2 SMG7 INCENP RBL1 TESK2 SIX2	1.88e-04	199	95	6	1500_DN
Drug	nifedipine; Down 200; 10uM; MCF7; HG-U133A	THEMIS2 DOCK1 KMT2A ACTN1 PHF21A PADI1	1.88e-04	199	95	6	603_DN
Drug	Dibucaine [85-79-0]; Down 200; 11.6uM; PC3; HT_HG-U133A	PNPLA6 LMAN1 SMG7 ASPH GNAS SIX2	1.88e-04	199	95	6	4068_DN
Drug	Ritodrine hydrochloride [23239-51-2]; Down 200; 12.4uM; HL60; HT_HG-U133A	PNPLA6 SMG7 PLCB3 PARD3 KAT6B SOS2	1.88e-04	199	95	6	1280_DN
Drug	Aconitine [302-27-2]; Up 200; 6.2uM; HL60; HG-U133A	ASPH MOB3B THSD1 RAPGEF2 SIX2 PADI1	1.88e-04	199	95	6	1784_UP
Drug	Pirenzepine dihydrochloride [29868-97-1]; Up 200; 9.4uM; MCF7; HT_HG-U133A	DOCK5 INCENP PAH KMT2A GNAS SOS2	1.88e-04	199	95	6	7226_UP
Drug	Chlorthalidone [77-36-1]; Up 200; 11.8uM; PC3; HT_HG-U133A	PHKA2 SMG7 RBM26 GNAS RAPGEF2 AQR	1.94e-04	200	95	6	7152_UP
Disease	branchiootorenal syndrome (implicated_via_orthology)	SIX5 SIX4 SIX1	1.12e-06	7	95	3	DOID:14702 (implicated_via_orthology)
Disease	thrombopoietin receptor measurement	MPL NLRP12	3.07e-05	3	95	2	EFO_0020769
Disease	Branchiootorenal Spectrum Disorders	SIX5 SIX1	3.07e-05	3	95	2	cv:CN043574
Disease	Branchio-Oto-Renal Syndrome	SIX5 SIX1	6.13e-05	4	95	2	C0265234
Disease	carbon monoxide exhalation measurement	SIX4 SIX1	6.13e-05	4	95	2	EFO_0006520
Disease	Branchio-Oculo-Facial Syndrome	SIX5 SIX1	6.13e-05	4	95	2	C0376524
Disease	Branchiootorenal Syndrome 2	SIX5 SIX1	6.13e-05	4	95	2	C1970479
Disease	Branchiootorenal Syndrome 1	SIX5 SIX1	6.13e-05	4	95	2	C4551702
Disease	Hepatolenticular Degeneration	PPP3CA LOXL2 CP	6.23e-05	24	95	3	C0019202
Disease	Hepatic Form of Wilson Disease	PPP3CA LOXL2 CP	6.23e-05	24	95	3	C1527352
Disease	myotonic dystrophy type 1 (implicated_via_orthology)	SIX5 SIX4	1.53e-04	6	95	2	DOID:11722 (implicated_via_orthology)
Disease	myelofibrosis (is_implicated_in)	MPL KMT2A	2.84e-04	8	95	2	DOID:4971 (is_implicated_in)
Disease	Acute erythroleukemia - M6a subtype	KMT2A DDX41	2.84e-04	8	95	2	C2930975
Disease	Acute myeloid leukemia FAB-M6	KMT2A DDX41	2.84e-04	8	95	2	C2930976
Disease	Acute erythroleukemia - M6b subtype	KMT2A DDX41	2.84e-04	8	95	2	C2930977
Disease	Acute erythroleukemia	KMT2A DDX41	2.84e-04	8	95	2	C2930974
Disease	phenylalanine measurement	PAH KIF13A ATP2B4	7.51e-04	55	95	3	EFO_0005001
Disease	cortical thickness	FBXW10 SMG7 FAT3 WNT16 MUS81 KMT2A PARD3 KIF13A PLEKHA7 SMG6 SOS2	9.05e-04	1113	95	11	EFO_0004840
Disease	cholesteryl esters to total lipids in large HDL percentage	PSKH1 LPA PLCB3	9.22e-04	59	95	3	EFO_0022248
Disease	immature granulocyte count	NLRP12 SLC44A4	1.35e-03	17	95	2	EFO_0803542
Disease	perceived unattractiveness to mosquitos measurement	ACSL6 SAXO1 SLC44A4	1.64e-03	72	95	3	EFO_0008380
Disease	Systemic Scleroderma	IRF5 PHF21A	1.69e-03	19	95	2	C0036421
Disease	polycystic kidney disease (biomarker_via_orthology)	PLA2G4A GNAS	1.69e-03	19	95	2	DOID:0080322 (biomarker_via_orthology)
Disease	BRCAX breast cancer	DOCK1 ASPH	1.88e-03	20	95	2	EFO_0009443
Disease	reticulocyte count	DOCK5 CLASP1 TESK2 FKBP9 PLCB3 ACTN1 PLEKHA7 ATP2B4 THRAP3 SMG6	1.98e-03	1045	95	10	EFO_0007986
Disease	cholangiocarcinoma (is_implicated_in)	ASPH GNAS	2.27e-03	22	95	2	DOID:4947 (is_implicated_in)
Disease	Malignant neoplasm of breast	THEMIS2 LOXL2 ESRRA MRPS23 PLA2G4A SIX4 TRAPPC8 KAT6B SPEN CLASRP	2.41e-03	1074	95	10	C0006142
Disease	Noonan Syndrome	KAT6B SOS2	2.70e-03	24	95	2	C0028326
Disease	Antiglaucoma preparations and miotics use measurement	KMT2A SIX6	3.17e-03	26	95	2	EFO_0009944

Protein segments in the cluster

Peptide	Gene	Start	Entry
RKDNRRPDLEIYKPG	SMG6	41	Q86US8
RKPIFGRYKPDTLAV	FAM234A	371	Q9H0X4
VRPDTQYTGRKRKPR	BUD23	266	O43709
FRDYRRLHKPPKVQE	ACTN1	316	P12814
AADFLKRRRPKNYPP	CYP2J2	31	P51589
KKERPRIYTALDPFR	FBXW10	966	Q5XX13
RFKPTRIIFYRDGVP	AGO1	656	Q9UL18
TVRPTKPYGTKFDRR	AQR	566	O60306
KPYGTKFDRRRPFIE	AQR	571	O60306
ELVRKYPQSPRARYG	ASPH	366	Q12797
RIPGRRFPVDIFYTK	DHX16	571	O60231
TESLLKRRPYGRNKP	ATP2B4	896	P23634
KDDRSRKRDYDRNPP	RBM26	146	Q5T8P6
DSPRNRGLKDFPYKR	PADI1	371	Q9ULC6
RGLKDFPYKRILGPD	PADI1	376	Q9ULC6
VKRPLLDPRFEGYKL	NUDCD1	11	Q96RS6
AAQIKRRYAKPIGRP	KAT6B	331	Q8WYB5
RPKRKFEPGTQRFEL	MOB3B	16	Q86TA1
RRPYLKVFNPRRKLE	CP	901	P00450
PDGPRYRFRKRDKVL	PNPLA6	91	Q8IY17
DKPRRLGRLKYQAPD	NOP53	401	Q9NZM5
REPPQSARRKRSYKQ	INCENP	441	Q9NQS7
RSRKYQEGPDAERRP	GPSM1	451	Q86YR5
EYRRTNFEGPPRLKE	FSD1	201	Q9BTV5
FRPKRKFEPGTQRFE	MOB3A	16	Q96BX8
EYGRKGRLKSLPFER	FRMD7	311	Q6ZUT3
EPPRRARVAKYRAKF	PSKH1	76	P11801
GPSRFRKAYKPEQPL	LOXL2	311	Q9Y4K0
RKAYKPEQPLVRLRG	LOXL2	316	Q9Y4K0
DIRRYFGRKDKGQDP	PERCC1	96	A0A1W2PR82
RKRGRPPKYNAVLGF	PHF21A	426	Q96BD5
QRDFRNKPYPVRAKI	LMAN1	191	P49257
LKQEEDRPKRRGPAY	MOK	331	Q9UQ07
EIKFQYRGRPPRALT	IRF5	251	Q13568
QEKRLPFSKREGPYG	DDX41	246	Q9UJV9
HPGFKDPVYRARRKQ	PAH	146	P00439
DTRTGRYARLPKDPK	PLCB3	71	Q01970
RRFVKIPPKLAYGNE	FKBP9	106	O95302
DDIKPRRIRKPRYGS	CASC3	251	O15234
RFEYSRPIRKGEKNP	DOCK1	1436	Q14185
QFRYSRPFRKGEKDP	DOCK5	1461	Q9H7D0
RDRKKRGEPIYRAFA	FAT3	1266	Q8TDW7
RYFIKVPRSQEEPGK	FOXK1	361	P85037
RPNKPGVYARVSRFV	LPA	2016	P08519
PQEDGSFKRRYPRRS	KMT2A	2606	Q03164
PVKYDPSFRGPIKNR	SLC44A4	16	Q53GD3
FKLGKYLSDRREPGP	PRDM13	31	Q9H4Q3
YLSDRREPGPKKKVR	PRDM13	36	Q9H4Q3
GGRQKYKRRPEVDPL	ESRRA	156	P11474
DIRKLDRFKEPPAYG	PPP3CA	211	Q08209
FLRDGYKTPREDPNR	PHKA2	296	P46019
RLNRLQTPEKGRPFY	PARD3	1341	Q8TEW0
NFRKYRAPGVPRETE	PLA2G4A	646	P47712
VPEAKRLYGKRGDPF	KIF13A	766	Q9H1H9
LREPVFQRPRVRYGK	MRPS23	41	Q9Y3D9
FQRPRVRYGKAKAPI	MRPS23	46	Q9Y3D9
LYQVTRKFRDEPRPR	PARS2	181	Q7L3T8
EAKKESLPRRRRPAY	UTP15	321	Q8TED0
DRIYKQYSPRRRPGD	SOS2	386	Q07890
ESFKPRREYQKGPIP	SAXO1	51	Q8IYX7
YEEPPKLPRSRKQRR	RBL1	151	P28749
LKPYEGRPSFPKAAR	RFX3	581	P48380
PGEDPRVTRAKYFIR	GNAS	971	Q5JWF2
GRSFPPKEVRRDYSK	SMG7	561	Q92540
PLEGKRDRSKARSPY	PLEKHA7	351	Q6IQ23
YTEAKRPPGFDRVRN	STT3A	651	P46977
PLGAVDKYRLRRKFP	SIX4	201	Q9UIU6
RGNRYPTPDEKRRLA	SIX5	221	Q8N196
KLRGRPLGPVDKYRV	SIX6	101	O95475
VGKYRVRRKFPLPRT	SIX1	106	Q15475
FDIYTRKGPLENPKR	TFB2M	271	Q9H5Q4
RLTKPERGKLFYVPQ	ABCD3	496	P28288
RGPNVFKGYLKDPDR	ACSL6	511	Q9UKU0
DALKKPVRRRYEPYG	CLASP1	806	Q7Z460
EKRLRGRKISPPSYA	CLASRP	276	Q8N2M8
VPKREEKRPYGEFER	TCEAL7	16	Q9BRU2
KGLIARKEGRYREPP	RAPGEF2	1386	Q9Y4G8
TSYKGKFKRRPREFP	THEMIS	336	Q8N1K5
KPFRGSQSPKRYKLR	THRAP3	401	Q9Y2W1
PIEVRNYSRLKPGYR	WDFY3	3371	Q8IZQ1
PPRYEKLDKSRLERY	SPEN	771	Q96T58
RSKFYVREPPNAKPD	NDUFC1	26	O43677
FGRKKYDIDPRNGIP	SPATS1	186	Q496A3
RPTRPDKARRLGYKA	RPL15	41	P61313
VVTVFKEAPRYPGKR	THSD1	271	Q9NS62
QGKLRRRPREFPTAY	THEMIS2	321	Q5TEJ8
AAEKRPAGDYVPRKA	TCEAL6	96	Q6IPX3
RPFREKVLAYKSQPR	USP12	61	O75317
RNPYDRKRQDKAPVG	USP25	156	Q9UHP3
PDDVRRKFALRLPGY	YJEFN3	276	A6XGL0
RDLRPAGSKTRKIPY	TECR	216	Q9NZ01
KRKPYLLPSIREGAR	WNT16	61	Q9UBV4
RYELRYGPRDPKNST	MPL	166	P40238
PGYLKDPRYQEVDRR	YTHDC1	561	Q96MU7
VGKYRVRRKFPLPRS	SIX2	106	Q9NPC8
GPIGLPRKRDRKYDT	ZFP69B	241	Q9UJL9
PRKRDRKYDTPGKRS	ZFP69B	246	Q9UJL9
EKTSVKYGPDRRLDP	TRAPPC8	891	Q9Y2L5
YESPDPERRKRFPGK	AGPAT5	296	Q9NUQ2
YYRPRDGAARTPKVN	TESK2	386	Q96S53
PRKDPQETYRDYVRR	NLRP12	121	P59046
RRYPLPLRSGKEAKI	MUS81	51	Q96NY9