Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF419 ZFP42 ZNF219 ZNF337 FEZF1 ZNF408 ZNF316 ZBTB9 ZFP92 ZNF221 ZNF319 MGA ZNF865 ZKSCAN5 ZNF786 ZNF169 TP53 ZNF697 VDR TBX6	6.00e-11	1459	49	20	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF419 ZFP42 ZNF219 ZNF337 FEZF1 ZNF408 ZNF316 ZBTB9 ZFP92 ZNF221 ZNF319 MGA ZKSCAN5 ZNF786 ZNF169 TP53 ZNF697 VDR TBX6	2.98e-10	1412	49	19	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF419 ZFP42 ZNF219 FEZF1 ZNF408 ZNF316 ZBTB9 ZFP92 ZNF221 ZNF319 MGA ZNF865 ZKSCAN5 ZNF786 TP53 ZNF697 VDR TBX6	3.22e-10	1244	49	18	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF419 ZFP42 ZNF219 FEZF1 ZNF408 ZNF316 ZBTB9 ZFP92 ZNF221 ZNF319 MGA ZNF865 ZKSCAN5 ZNF786 TP53 ZNF697 VDR TBX6	4.55e-10	1271	49	18	GO:0000987
GeneOntologyMolecularFunction	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	MAN2A2 MAN2A1	5.90e-06	2	49	2	GO:0004572
GeneOntologyMolecularFunction	mannosyl-oligosaccharide mannosidase activity	MAN2A2 MAN2A1	2.62e-04	10	49	2	GO:0015924
GeneOntologyMolecularFunction	extracellular matrix constituent conferring elasticity	FBN1 FBN2	3.83e-04	12	49	2	GO:0030023
GeneOntologyMolecularFunction	structural molecule activity conferring elasticity	FBN1 FBN2	5.27e-04	14	49	2	GO:0097493
GeneOntologyMolecularFunction	alpha-mannosidase activity	MAN2A2 MAN2A1	6.07e-04	15	49	2	GO:0004559
GeneOntologyMolecularFunction	mannosidase activity	MAN2A2 MAN2A1	6.93e-04	16	49	2	GO:0015923
GeneOntologyBiologicalProcess	negative regulation of transforming growth factor beta receptor signaling pathway	FBN1 FBN2 LRP1 CHST11 TP53	1.88e-05	138	49	5	GO:0030512
GeneOntologyBiologicalProcess	sequestering of TGFbeta in extracellular matrix	FBN1 FBN2	3.31e-05	4	49	2	GO:0035583
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	BCLAF3 PRDM9 ZFP42 ZNF219 PPRC1 POGZ ZNF319 MGA ZNF786 TP53 VDR TBX6	7.46e-05	1390	49	12	GO:0045944
GeneOntologyBiologicalProcess	regulation of transforming growth factor beta receptor signaling pathway	FBN1 FBN2 LRP1 CHST11 TP53	9.07e-05	192	49	5	GO:0017015
GeneOntologyBiologicalProcess	regulation of cellular response to transforming growth factor beta stimulus	FBN1 FBN2 LRP1 CHST11 TP53	9.76e-05	195	49	5	GO:1903844
GeneOntologyBiologicalProcess	cellular response to transforming growth factor beta stimulus	FBN1 FBN2 PDGFD LRP1 CHST11 TP53	1.39e-04	336	49	6	GO:0071560
GeneOntologyBiologicalProcess	maintenance of protein location in extracellular region	FBN1 FBN2	1.53e-04	8	49	2	GO:0071694
GeneOntologyBiologicalProcess	response to transforming growth factor beta	FBN1 FBN2 PDGFD LRP1 CHST11 TP53	1.55e-04	343	49	6	GO:0071559
GeneOntologyBiologicalProcess	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	FBN1 FBN2 LRP1 CHST11 TP53	1.65e-04	218	49	5	GO:0090101
GeneOntologyBiologicalProcess	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	FBN1 FBN2 LRP1 CHST11 ZC3H3 TP53	1.65e-04	347	49	6	GO:0090092
GeneOntologyBiologicalProcess	sequestering of extracellular ligand from receptor	FBN1 FBN2	3.00e-04	11	49	2	GO:0035581
GeneOntologyBiologicalProcess	mannose metabolic process	MAN2A2 MAN2A1	3.59e-04	12	49	2	GO:0006013
GeneOntologyBiologicalProcess	extracellular regulation of signal transduction	FBN1 FBN2	4.24e-04	13	49	2	GO:1900115
GeneOntologyBiologicalProcess	extracellular negative regulation of signal transduction	FBN1 FBN2	4.24e-04	13	49	2	GO:1900116
GeneOntologyBiologicalProcess	transforming growth factor beta receptor signaling pathway	FBN1 FBN2 LRP1 CHST11 TP53	4.88e-04	276	49	5	GO:0007179
GeneOntologyBiologicalProcess	bone trabecula formation	FBN2 VDR	4.94e-04	14	49	2	GO:0060346
HumanPheno	Abnormal upper to lower segment ratio	FBN1 FBN2	2.42e-05	3	15	2	HP:0012772
Domain	ZINC_FINGER_C2H2_2	ZNF419 PRDM9 ZFP42 ZNF219 ZNF337 FEZF1 ZNF408 ZNF316 ZBTB9 ZFP92 POGZ ZNF221 ZNF223 ZNF319 ZNF865 ZKSCAN5 ZNF654 ZNF786 ZNF169 ZNF697	1.64e-15	775	49	20	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF419 PRDM9 ZFP42 ZNF219 ZNF337 FEZF1 ZNF408 ZNF316 ZBTB9 ZFP92 POGZ ZNF221 ZNF223 ZNF319 ZNF865 ZKSCAN5 ZNF654 ZNF786 ZNF169 ZNF697	1.72e-15	777	49	20	PS00028
Domain	-	ZNF419 PRDM9 ZFP42 ZNF219 ZNF337 FEZF1 ZNF408 ZNF316 ZBTB9 ZFP92 ZNF221 ZNF223 ZNF319 ZNF865 ZKSCAN5 ZNF654 ZNF786 ZNF169 ZNF697	2.37e-15	679	49	19	3.30.160.60
Domain	Znf_C2H2-like	ZNF419 PRDM9 ZFP42 ZNF219 ZNF337 FEZF1 ZNF408 ZNF316 ZBTB9 ZFP92 POGZ ZNF221 ZNF223 ZNF319 ZNF865 ZKSCAN5 ZNF654 ZNF786 ZNF169 ZNF697	2.72e-15	796	49	20	IPR015880
Domain	Znf_C2H2	ZNF419 PRDM9 ZFP42 ZNF219 ZNF337 FEZF1 ZNF408 ZNF316 ZBTB9 ZFP92 POGZ ZNF221 ZNF223 ZNF319 ZNF865 ZKSCAN5 ZNF654 ZNF786 ZNF169 ZNF697	3.37e-15	805	49	20	IPR007087
Domain	Znf_C2H2/integrase_DNA-bd	ZNF419 PRDM9 ZFP42 ZNF219 ZNF337 FEZF1 ZNF408 ZNF316 ZBTB9 ZFP92 ZNF221 ZNF223 ZNF319 ZNF865 ZKSCAN5 ZNF654 ZNF786 ZNF169 ZNF697	3.52e-15	694	49	19	IPR013087
Domain	ZnF_C2H2	ZNF419 PRDM9 ZFP42 ZNF219 ZNF337 FEZF1 ZNF408 ZNF316 ZBTB9 ZFP92 POGZ ZNF221 ZNF223 ZNF319 ZNF865 ZKSCAN5 ZNF654 ZNF786 ZNF169 ZNF697	3.62e-15	808	49	20	SM00355
Domain	zf-C2H2	ZNF419 PRDM9 ZNF219 ZNF337 FEZF1 ZNF408 ZNF316 ZBTB9 ZFP92 POGZ ZNF221 ZNF223 ZNF319 ZNF865 ZKSCAN5 ZNF786 ZNF169 ZNF697	5.63e-14	693	49	18	PF00096
Domain	KRAB	ZNF419 PRDM9 ZNF337 ZNF316 ZFP92 ZNF221 ZNF223 ZKSCAN5 ZNF786 ZNF169	2.50e-08	358	49	10	PF01352
Domain	KRAB	ZNF419 PRDM9 ZNF337 ZNF316 ZFP92 ZNF221 ZNF223 ZKSCAN5 ZNF786 ZNF169	3.32e-08	369	49	10	SM00349
Domain	KRAB	ZNF419 PRDM9 ZNF337 ZNF316 ZFP92 ZNF221 ZNF223 ZKSCAN5 ZNF786 ZNF169	3.41e-08	370	49	10	IPR001909
Domain	zf-C2H2_6	ZNF419 PRDM9 FEZF1 ZNF408 ZNF316 ZFP92 ZNF865 ZKSCAN5 ZNF169	1.09e-07	314	49	9	PF13912
Domain	KRAB	ZNF419 ZNF337 ZNF316 ZFP92 ZNF221 ZNF223 ZKSCAN5 ZNF786 ZNF169	3.30e-07	358	49	9	PS50805
Domain	FBN	FBN1 FBN2	2.02e-05	3	49	2	IPR011398
Domain	cEGF	FBN1 FBN2 LRP1	4.23e-05	26	49	3	IPR026823
Domain	cEGF	FBN1 FBN2 LRP1	4.23e-05	26	49	3	PF12662
Domain	Growth_fac_rcpt_	TNFRSF9 FBN1 FBN2 MEGF6 LRP1	5.40e-05	156	49	5	IPR009030
Domain	-	MAN2A2 MAN2A1	6.71e-05	5	49	2	1.20.1270.50
Domain	-	MAN2A2 MAN2A1	6.71e-05	5	49	2	3.20.110.10
Domain	Glyco_hydro_38_C	MAN2A2 MAN2A1	6.71e-05	5	49	2	IPR011682
Domain	Alpha-mann_mid	MAN2A2 MAN2A1	6.71e-05	5	49	2	SM00872
Domain	Glyco_hydro_38_cen	MAN2A2 MAN2A1	6.71e-05	5	49	2	IPR015341
Domain	Glyco_hydro_57/38_cen	MAN2A2 MAN2A1	6.71e-05	5	49	2	IPR028995
Domain	Alpha-mann_mid	MAN2A2 MAN2A1	6.71e-05	5	49	2	PF09261
Domain	Glyco_hydro_38C	MAN2A2 MAN2A1	6.71e-05	5	49	2	PF07748
Domain	Glyco_hydro_38_N	MAN2A2 MAN2A1	6.71e-05	5	49	2	IPR000602
Domain	Glyco_hydro_38/57_N	MAN2A2 MAN2A1	6.71e-05	5	49	2	IPR027291
Domain	Glyco_hydro_38	MAN2A2 MAN2A1	6.71e-05	5	49	2	PF01074
Domain	EGF_CA	FBN1 FBN2 MEGF6 LRP1	7.58e-05	86	49	4	PF07645
Domain	EGF_Ca-bd_CS	FBN1 FBN2 MEGF6 LRP1	1.21e-04	97	49	4	IPR018097
Domain	EGF_CA	FBN1 FBN2 MEGF6 LRP1	1.31e-04	99	49	4	PS01187
Domain	ASX_HYDROXYL	FBN1 FBN2 MEGF6 LRP1	1.36e-04	100	49	4	PS00010
Domain	Glyco_hydro/deAcase_b/a-brl	MAN2A2 MAN2A1	1.40e-04	7	49	2	IPR011330
Domain	TB	FBN1 FBN2	1.40e-04	7	49	2	PF00683
Domain	EGF-type_Asp/Asn_hydroxyl_site	FBN1 FBN2 MEGF6 LRP1	1.71e-04	106	49	4	IPR000152
Domain	-	FBN1 FBN2	1.87e-04	8	49	2	3.90.290.10
Domain	TB	FBN1 FBN2	2.40e-04	9	49	2	PS51364
Domain	TB_dom	FBN1 FBN2	2.40e-04	9	49	2	IPR017878
Domain	EGF_CA	FBN1 FBN2 MEGF6 LRP1	2.93e-04	122	49	4	SM00179
Domain	EGF-like_Ca-bd_dom	FBN1 FBN2 MEGF6 LRP1	3.11e-04	124	49	4	IPR001881
Domain	p53-like_TF_DNA-bd	MGA TP53 TBX6	3.62e-04	53	49	3	IPR008967
Domain	EGF_3	FBN1 FBN2 MEGF6 TMEM8B LRP1	3.67e-04	235	49	5	PS50026
Domain	EGF	FBN1 FBN2 MEGF6 TMEM8B LRP1	3.67e-04	235	49	5	SM00181
Domain	EGF_1	FBN1 FBN2 MEGF6 TMEM8B LRP1	5.33e-04	255	49	5	PS00022
Domain	EGF-like_CS	FBN1 FBN2 MEGF6 TMEM8B LRP1	5.92e-04	261	49	5	IPR013032
Domain	-	MAN2A2 MAN2A1	6.01e-04	14	49	2	2.60.40.1180
Domain	EGF_2	FBN1 FBN2 MEGF6 TMEM8B LRP1	6.34e-04	265	49	5	PS01186
Domain	Glyco_hydro_b	MAN2A2 MAN2A1	6.93e-04	15	49	2	IPR013780
Domain	Gal_mutarotase_SF_dom	MAN2A2 MAN2A1	8.94e-04	17	49	2	IPR011013
Domain	TF_T-box	MGA TBX6	8.94e-04	17	49	2	IPR001699
Domain	TBOX_3	MGA TBX6	8.94e-04	17	49	2	PS50252
Domain	TBOX	MGA TBX6	8.94e-04	17	49	2	SM00425
Domain	TF_T-box_CS	MGA TBX6	8.94e-04	17	49	2	IPR018186
Domain	T-box	MGA TBX6	8.94e-04	17	49	2	PF00907
Domain	-	MGA TBX6	8.94e-04	17	49	2	2.60.40.820
Domain	TBOX_1	MGA TBX6	8.94e-04	17	49	2	PS01283
Domain	TBOX_2	MGA TBX6	8.94e-04	17	49	2	PS01264
Domain	hEGF	FBN2 MEGF6	2.44e-03	28	49	2	PF12661
Domain	EGF-like_dom	FBN1 FBN2 MEGF6 LRP1	4.08e-03	249	49	4	IPR000742
Pubmed	Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.	FBN1 FBN2 MEGF6	2.19e-07	9	49	3	12122015
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF219 FBN2 HPN ZNF316 ZBTB9 LRP1 POGZ MGA ZC3H3 ZKSCAN5 TP53	3.37e-07	1116	49	11	31753913
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF419 ZNF219 POGZ MGA ZNF654 ZNF786 TP53 ZNF697 VDR	1.69e-06	808	49	9	20412781
Pubmed	Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.	FBN1 FBN2	1.94e-06	2	49	2	12399449
Pubmed	Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.	FBN1 FBN2	1.94e-06	2	49	2	21851253
Pubmed	New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.	FBN1 FBN2	1.94e-06	2	49	2	30044367
Pubmed	Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.	FBN1 FBN2	1.94e-06	2	49	2	21440062
Pubmed	MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.	FBN1 FBN2	1.94e-06	2	49	2	15131124
Pubmed	Microfibril structure masks fibrillin-2 in postnatal tissues.	FBN1 FBN2	1.94e-06	2	49	2	20404337
Pubmed	Fibrillln mutations in Marfan syndrome and related phenotypes.	FBN1 FBN2	1.94e-06	2	49	2	8791520
Pubmed	Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.	FBN1 FBN2	1.94e-06	2	49	2	8307578
Pubmed	Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.	FBN1 FBN2	1.94e-06	2	49	2	7744963
Pubmed	Fibrillin microfibrils in bone physiology.	FBN1 FBN2	1.94e-06	2	49	2	26408953
Pubmed	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	FBN1 FBN2	1.94e-06	2	49	2	18006876
Pubmed	Modulation of the vitamin D3 response by cancer-associated mutant p53.	TP53 VDR	1.94e-06	2	49	2	20227041
Pubmed	Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.	MAN2A2 MAN2A1	1.94e-06	2	49	2	8524845
Pubmed	Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.	FBN1 FBN2	1.94e-06	2	49	2	24833718
Pubmed	Exome sequencing identified new mutations in a Marfan syndrome family.	FBN1 LRP1	1.94e-06	2	49	2	24484584
Pubmed	Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.	FBN1 FBN2	1.94e-06	2	49	2	24265020
Pubmed	In vivo studies of mutant fibrillin-1 microfibrils.	FBN1 FBN2	1.94e-06	2	49	2	20529844
Pubmed	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	FBN1 FBN2	1.94e-06	2	49	2	23133647
Pubmed	Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.	FBN1 FBN2	1.94e-06	2	49	2	1852206
Pubmed	Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice.	MAN2A2 MAN2A1	1.94e-06	2	49	2	16754854
Pubmed	Genetic mutation of p53 and suppression of the miR-17∼92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D Signaling.	TP53 VDR	1.94e-06	2	49	2	25519225
Pubmed	Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.	FBN1 FBN2	1.94e-06	2	49	2	12429739
Pubmed	Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.	FBN1 FBN2	1.94e-06	2	49	2	12524050
Pubmed	Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.	FBN1 FBN2	1.94e-06	2	49	2	8120105
Pubmed	The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.	FBN1 FBN2	1.94e-06	2	49	2	35419902
Pubmed	Fibrillin assembly: dimer formation mediated by amino-terminal sequences.	FBN1 FBN2	1.94e-06	2	49	2	10504303
Pubmed	Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.	FBN1 FBN2	1.94e-06	2	49	2	25524144
Pubmed	N-Glycan structure analysis using lectins and an alpha-mannosidase activity assay.	MAN2A2 MAN2A1	1.94e-06	2	49	2	17113875
Pubmed	Fibrillins 1 and 2 perform partially overlapping functions during aortic development.	FBN1 FBN2	1.94e-06	2	49	2	16407178
Pubmed	Germ cell survival through carbohydrate-mediated interaction with Sertoli cells.	MAN2A2 MAN2A1	1.94e-06	2	49	2	11778047
Pubmed	N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.	FBN1 FBN2	1.94e-06	2	49	2	10359653
Pubmed	Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.	FBN1 FBN2	5.83e-06	3	49	2	10825173
Pubmed	Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.	FBN1 FBN2	5.83e-06	3	49	2	30201140
Pubmed	Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice.	PLXND1 TP53	5.83e-06	3	49	2	31163177
Pubmed	Coding region intron/exon organization, alternative splicing, and X-chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41.	ZNF221 ZNF223	5.83e-06	3	49	2	10449920
Pubmed	Calcium, vitamin D, VDR genotypes, and epigenetic and genetic changes in rectal tumors.	TP53 VDR	5.83e-06	3	49	2	20432164
Pubmed	Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.	FBN1 FBN2	5.83e-06	3	49	2	20855508
Pubmed	Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy.	TP53 VDR	5.83e-06	3	49	2	25259922
Pubmed	Claudin-1 expression decreases with increasing pathological grade in actinic keratosis and may be a marker of high-risk actinic keratosis.	TP53 VDR	5.83e-06	3	49	2	30315595
Pubmed	A systematic review and network meta-analysis of single nucleotide polymorphisms associated with pancreatic cancer risk.	TP53 VDR	5.83e-06	3	49	2	33226370
Pubmed	Vitamin D receptor deficit induces activation of renin angiotensin system via SIRT1 modulation in podocytes.	TP53 VDR	5.83e-06	3	49	2	28069388
Pubmed	Mechanisms Regulating Acquisition of Platelet-Derived Factor V/Va by Megakaryocytes.	LRP1 LGALS8	5.83e-06	3	49	2	25800007
Pubmed	Human eye development is characterized by coordinated expression of fibrillin isoforms.	FBN1 FBN2	1.16e-05	4	49	2	25406291
Pubmed	Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.	FBN1 FBN2	1.16e-05	4	49	2	20729550
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN2	1.16e-05	4	49	2	25034023
Pubmed	Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.	FBN1 FBN2	1.16e-05	4	49	2	12429738
Pubmed	Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.	FBN1 FBN2	1.16e-05	4	49	2	16835936
Pubmed	Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin.	HPN TP53	1.16e-05	4	49	2	33461973
Pubmed	Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.	FBN1 FBN2	1.94e-05	5	49	2	26601954
Pubmed	Association of the 3' UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer's disease.	LRP1 VDR	1.94e-05	5	49	2	12555245
Pubmed	Association of familial colorectal cancer with variants in the E-cadherin (CDH1) and cyclin D1 (CCND1) genes.	TP53 VDR	1.94e-05	5	49	2	17960397
Pubmed	Development, composition, and structural arrangements of the ciliary zonule of the mouse.	FBN1 FBN2	1.94e-05	5	49	2	23493297
Pubmed	Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.	FBN1 FBN2	1.94e-05	5	49	2	12590922
Pubmed	Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.	FBN1 FBN2	1.94e-05	5	49	2	17255108
Pubmed	POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.	FBN1 FBN2	1.94e-05	5	49	2	34411563
Pubmed	Expressed repetitive elements are broadly applicable reference targets for normalization of reverse transcription-qPCR data in mice.	FBN1 TP53	1.94e-05	5	49	2	29769563
Pubmed	Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response.	TRADD TP53	2.91e-05	6	49	2	17567906
Pubmed	Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome.	FBN1 FBN2	2.91e-05	6	49	2	7873879
Pubmed	Congenital Diaphragmatic Hernia Overview	FBN1 POGZ TBX6	3.82e-05	46	49	3	20301533
Pubmed	Comparative analysis of a conserved zinc finger gene cluster on human chromosome 19q and mouse chromosome 7.	ZNF223 ZKSCAN5	4.07e-05	7	49	2	8617494
Pubmed	Regulation of limb patterning by extracellular microfibrils.	FBN1 FBN2	4.07e-05	7	49	2	11470817
Pubmed	Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis.	FBN1 FBN2	5.42e-05	8	49	2	23055981
Pubmed	Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.	FBN1 FBN2	5.42e-05	8	49	2	31201465
Pubmed	Analysis of polymorphic patterns in candidate genes in Israeli patients with prostate cancer.	TP53 VDR	5.42e-05	8	49	2	14719475
Pubmed	ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis.	PRDM9 TP53	5.42e-05	8	49	2	32051414
Pubmed	Targeting of bone morphogenetic protein growth factor complexes to fibrillin.	FBN1 FBN2	5.42e-05	8	49	2	18339631
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	ZFP42 ZNF219 POGZ MGA	5.45e-05	146	49	4	23892456
Pubmed	Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.	FBN1 FBN2	6.96e-05	9	49	2	38844137
Pubmed	Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia.	FBN1 FBN2	8.69e-05	10	49	2	30738849
Pubmed	HIV-1 gp120 N-linked glycosylation differs between plasma and leukocyte compartments.	MAN2A2 MAN2A1	8.69e-05	10	49	2	18215327
Pubmed	Glycosylation site-specific analysis of HIV envelope proteins (JR-FL and CON-S) reveals major differences in glycosylation site occupancy, glycoform profiles, and antigenic epitopes' accessibility.	MAN2A2 MAN2A1	8.69e-05	10	49	2	18330979
Pubmed	Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses.	MAN2A2 MAN2A1	8.69e-05	10	49	2	18314154
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	ZNF219 ZBTB9 POGZ MGA	9.18e-05	167	49	4	20362541
Pubmed	A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development.	FBN1 FBN2	1.27e-04	12	49	2	36779913
Pubmed	Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.	FBN1 FBN2	1.27e-04	12	49	2	26405179
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	FBN1 FBN2 LRP1 MGA	1.33e-04	184	49	4	32908313
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	FBN1 FBN2 LRP1	1.40e-04	71	49	3	33541421
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MAN2A2 MEGF6 PPRC1 TMEM8B ZNF408 ZNF316 PLXND1 ZNF865	1.44e-04	1105	49	8	35748872
Pubmed	gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer.	MAN2A1 TP53	1.50e-04	13	49	2	9472029
Pubmed	Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.	POGZ MGA RPL17	1.59e-04	74	49	3	29795351
Pubmed	Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.	MAN2A2 MAN2A1	2.02e-04	15	49	2	8892864
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ZFP42 ZNF219 ZNF408 ZBTB9 ZKSCAN5 TP53 VDR	2.16e-04	877	49	7	20211142
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	FBN1 FBN2 MAN2A2 MAN2A1 MAT2B LRP1 PLXND1 DIPK2A	2.53e-04	1201	49	8	35696571
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	FBN2 ZNF316 LRP1 POGZ ZNF319 MGA ZNF697 RPL17	2.56e-04	1203	49	8	29180619
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	FBN1 FBN2 LRP1 POGZ	2.60e-04	219	49	4	31353912
Pubmed	Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.	MAN2A2 MAN2A1	2.61e-04	17	49	2	2355006
Pubmed	Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.	TP53 VDR	2.93e-04	18	49	2	10198638
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	FBN1 FBN2	2.93e-04	18	49	2	35503090
Pubmed	ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.	FBN1 FBN2	2.93e-04	18	49	2	39040056
Pubmed	Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin.	MAN2A2 MAN2A1	3.64e-04	20	49	2	12560567
Pubmed	Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.	ZNF221 ZNF223	3.64e-04	20	49	2	12743021
Pubmed	Effect of germ-line genetic variation on breast cancer survival in a population-based study.	TP53 VDR	3.64e-04	20	49	2	12036913
Pubmed	Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.	MAN2A2 MAN2A1	4.41e-04	22	49	2	8673525
Pubmed	Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation.	MAN2A2 MAN2A1	4.41e-04	22	49	2	9109416
Pubmed	Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum.	MAN2A2 MAN2A1	4.41e-04	22	49	2	11530211
Pubmed	Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain.	MAN2A2 MAN2A1	4.83e-04	23	49	2	8093218
Pubmed	Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins.	MAN2A2 MAN2A1	4.83e-04	23	49	2	3099781
Interaction	NOTCH2 interactions	HSCB ZNF419 ZNF219 FBN2 ZNF408 ZNF316 ZBTB9 ZNF865 ZC3H3 RPL17	5.91e-08	423	49	10	int:NOTCH2
Interaction	KRTAP10-7 interactions	ZNF419 ZNF337 ZNF408 ZBTB9 ZNF223 ZNF786 ZNF169 ZNF697	4.88e-07	293	49	8	int:KRTAP10-7
Interaction	LTBP2 interactions	FBN2 ZNF408 ZNF316 ZBTB9 ZNF865	1.95e-06	85	49	5	int:LTBP2
Interaction	ZNF92 interactions	ZNF223 ZNF169 TP53 RPL17	9.60e-06	55	49	4	int:ZNF92
Interaction	TRIM41 interactions	ZNF219 ZNF408 ZNF223 ZNF319 ZNF169 TP53	1.61e-05	223	49	6	int:TRIM41
Interaction	VWCE interactions	FBN2 ZNF408 ZNF316 ZBTB9	1.76e-05	64	49	4	int:VWCE
Interaction	FBLN2 interactions	FBN1 ZNF408 ZNF316 ZNF865	1.99e-05	66	49	4	int:FBLN2
Interaction	ZNF460 interactions	ZNF337 PPRC1 ZNF408 ZNF316 POGZ	2.10e-05	138	49	5	int:ZNF460
Interaction	RSBN1 interactions	SPTBN4 PPRC1 ZNF865 TP53 RPL17	4.39e-05	161	49	5	int:RSBN1
Interaction	P3H2 interactions	ZNF219 FEZF1 TP53	4.72e-05	29	49	3	int:P3H2
Interaction	LRP1B interactions	FEZF1 ZNF408 LRP1 ZNF169	5.40e-05	85	49	4	int:LRP1B
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF419 SPTBN4 HPN ZNF221 ZNF223 ZNF865	1.63e-03	1192	49	6	chr19q13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF419 PRDM9 ZFP42 ZNF219 ZNF337 FEZF1 ZNF408 ZNF316 ZBTB9 ZFP92 ZNF221 ZNF223 ZNF319 ZNF865 ZKSCAN5 ZNF786 ZNF169 ZNF697	4.26e-16	718	37	18	28
GeneFamily	Mannosidases alpha class 2	MAN2A2 MAN2A1	4.06e-05	5	37	2	1194
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	PRDM9 ZNF408	5.44e-04	17	37	2	1197
GeneFamily	T-boxes	MGA TBX6	6.11e-04	18	37	2	766
Drug	PNU-0230031 [267429-39-0]; Up 200; 10uM; PC3; HT_HG-U133A	ZNF219 MAN2A2 MEGF6 LRP1 PLXND1 TBX6	3.87e-06	196	49	6	3732_UP
Drug	Aztreonam [78110-38-0]; Up 200; 9.2uM; MCF7; HT_HG-U133A	TNFRSF9 MAN2A2 TMEM8B PDGFD CHST11 ZKSCAN5	4.35e-06	200	49	6	5535_UP
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN2	7.44e-06	3	47	2	DOID:65 (implicated_via_orthology)
Disease	scoliosis (is_implicated_in)	FBN1 FBN2	1.49e-05	4	47	2	DOID:0060249 (is_implicated_in)
Disease	mesangial proliferative glomerulonephritis (biomarker_via_orthology)	FBN1 PDGFD	6.91e-05	8	47	2	DOID:4783 (biomarker_via_orthology)
Disease	basal cell carcinoma (is_marker_for)	TP53 VDR	6.91e-05	8	47	2	DOID:2513 (is_marker_for)
Disease	pulse pressure measurement, migraine without aura, susceptibility to, 4	LRP1 TP53	8.88e-05	9	47	2	EFO_0005763, MONDO_0011847
Disease	aortic aneurysm	FBN1 LRP1	1.11e-04	10	47	2	EFO_0001666
Disease	testosterone measurement	ZNF219 FBN2 HPN ZNF316 ZKSCAN5 ZNF654 CDC37L1 TP53 VDR	1.58e-04	1275	47	9	EFO_0004908
Disease	basal cell carcinoma (is_implicated_in)	TP53 VDR	1.62e-04	12	47	2	DOID:2513 (is_implicated_in)
Disease	T-Cell Lymphoma	MGA TP53	2.94e-04	16	47	2	C0079772
Disease	bone density	FBN2 ZNF408 PLXND1 ZKSCAN5 DIPK2A	3.73e-04	388	47	5	EFO_0003923
Disease	squamous cell carcinoma (is_implicated_in)	TP53 VDR	3.74e-04	18	47	2	DOID:1749 (is_implicated_in)
Disease	descending aortic diameter	SPTBN4 FBN1 LRP1	3.78e-04	88	47	3	EFO_0021788
Disease	low density lipoprotein cholesterol measurement, response to escitalopram, response to citalopram	ZFP42 CHST11	6.70e-04	24	47	2	EFO_0004611, EFO_0006329, EFO_0007871
Disease	spontaneous coronary artery dissection	FBN1 LRP1	1.12e-03	31	47	2	EFO_0010820
Disease	liver cirrhosis (biomarker_via_orthology)	FBN1 PDGFD	1.35e-03	34	47	2	DOID:5082 (biomarker_via_orthology)
Disease	melanoma (is_implicated_in)	TP53 VDR	1.35e-03	34	47	2	DOID:1909 (is_implicated_in)
Disease	pulse pressure measurement	SPTBN4 PRDM9 FBN1 FBN2 LRP1 CHST11 POGZ TP53	1.46e-03	1392	47	8	EFO_0005763

Protein segments in the cluster

Peptide	Gene	Start	Entry
FDRNVPRICGVCGDR	VDR	16	P11473
VGCGFRRARPKFEQV	MAT2B	56	Q9NZL9
ICCQFDFKRLPGGRF	MAN2A1	366	Q16706
RKRAPPCNNDFCRLG	MGA	1041	Q8IWI9
FNPRFKRAGCIVCNT	LGALS8	66	O00214
IGFKCRCRPGFRLKD	LRP1	2961	Q07954
VFFPRCLLVQRCGGN	PDGFD	291	Q9GZP0
PVCVRFERRGCVHGN	PLXND1	1046	Q9Y4D7
GRNSFEVRVCACPGR	TP53	266	P04637
PRGRFLAAICQDCGR	HPN	141	P05981
KPYVCRECGRGFSRQ	PRDM9	606	Q9NQV7
VRPFKSNFRGGRCQP	BCLAF3	646	A2AJT9
CRRGFIPNIRTGACQ	FBN1	231	P35555
DRRFLQLNKCPACFG	DIPK2A	46	Q8NDZ4
ICCQFDFKRLPGGRI	MAN2A2	366	P49641
CRRGFIPNIRTGACQ	FBN2	261	P35556
PFDLCFGGRRQFCKR	PPRC1	1611	Q5VV67
KNCNVDPRGCFRLFF	CDC37L1	231	Q7L3B6
VRCERGCPQNRFGVG	MEGF6	1286	O75095
GREDRFFCPQCRALQ	HSCB	51	Q8IWL3
LIVQLRFCGRQPCGR	TRADD	71	Q15628
RPFVCKVCGKGFRQA	FEZF1	286	A0PJY2
DGGRKICPRCNAQFR	POGZ	371	Q7Z3K3
QCVPFRRYNGGVGRC	RPL17	56	P18621
MRRNPFGVDICCRKG	CHST11	41	Q9NPF2
FRGCKVRQCGLGGRQ	CLRN2	66	A0PK11
GERPFACRECGKAFR	ZFP92	316	A6NM28
FARRGACPRGAQCQL	ZC3H3	781	Q8IXZ2
ERRFPCGVCQKSFKQ	ZNF865	221	P0CJ78
PFKCEQCGRGFRCRS	ZNF223	231	Q9UK11
FLCPHCGRAFRQRGN	ZNF408	496	Q9H9D4
CFGTFNDQKRGICRP	TNFRSF9	121	Q07011
SFACVICGRKFRNRG	ZNF654	571	Q8IZM8
RACNRRLFVPREGCG	SPTBN4	381	Q9H254
PFAKGFRENGRNCKR	TBX6	266	O95947
CGVGPRFVRCRNATA	TMEM8B	161	A6NDV4
GEKRFVCPFQGCNRR	ZFP42	271	Q96MM3
RPFACGECGKGFVRR	ZNF697	351	Q5TEC3
FSLRPFGCGICNKRF	ZBTB9	406	Q96C00
GNQELFPCEVCGRRF	ZC2HC1B	11	Q5TFG8
KPFRCAKCGRNFRQR	ZNF786	451	Q8N393
GERPFRCGECQKAFK	ZNF319	311	Q9P2F9
KPFRCDTCGKNFRQR	ZNF221	336	Q9UK13
EKPFRCADCGRGFAQ	ZNF316	856	A6NFI3
GEKPFKCNECGRLFR	ZNF419	451	Q96HQ0
RFPCPVCGKRFRFNS	ZNF219	56	Q9P2Y4
RPFVCQECGRGFRQK	ZNF169	316	Q14929
RPFKCNECGKGFGRR	ZKSCAN5	631	Q9Y2L8
FFCRDCGRGFTLKPN	ZNF337	516	Q9Y3M9