Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	MYT1L HIC1 RB1 SOX30 DACH1 PER1 BEND3 RELA ZNF217 ZNF318 MIDEAS ZNF503 PPARGC1B IGF2 RESF1 FOXL2 L3MBTL1 PER3 CBX6 GLIS1 CUX1 DNMT3A	1.97e-05	1413	120	22	GO:1902679
GeneOntologyCellularComponent	chromatin lock complex	RB1 L3MBTL1	1.08e-04	3	126	2	GO:0061793
Domain	Period_circadian-like_C	PER1 PER3	1.26e-04	3	122	2	IPR022728
Domain	Period_C	PER1 PER3	1.26e-04	3	122	2	PF12114
Domain	NUT	NUTM2A NUTM2B	4.18e-04	5	122	2	IPR024310
Domain	NUT_N	NUTM2A NUTM2B	4.18e-04	5	122	2	IPR024309
Domain	NUT	NUTM2A NUTM2B	4.18e-04	5	122	2	PF12881
Domain	GATASE	PFAS CTPS1	6.24e-04	6	122	2	IPR017926
Domain	Znf_C2HC	MYT1L L3MBTL1	6.24e-04	6	122	2	IPR002515
Domain	zf-C2HC	MYT1L L3MBTL1	6.24e-04	6	122	2	PF01530
Domain	GATASE_TYPE_1	PFAS CTPS1	6.24e-04	6	122	2	PS51273
Domain	ZF_CCHHC	MYT1L L3MBTL1	8.70e-04	7	122	2	PS51802
Domain	-	PFAS CTPS1	1.84e-03	10	122	2	3.40.50.880
Domain	PH	RAPH1 ARHGAP23 IQSEC2 GRK2 ELMO2 IRS2 PSD4	2.35e-03	278	122	7	SM00233
Domain	PH_DOMAIN	RAPH1 ARHGAP23 IQSEC2 GRK2 ELMO2 IRS2 PSD4	2.40e-03	279	122	7	PS50003
Domain	PH_domain	RAPH1 ARHGAP23 IQSEC2 GRK2 ELMO2 IRS2 PSD4	2.44e-03	280	122	7	IPR001849
Domain	Class_I_gatase-like	PFAS CTPS1	2.68e-03	12	122	2	IPR029062
Domain	CUB	DCBLD1 CSMD2 CSMD1	4.02e-03	49	122	3	PF00431
Domain	-	RAPH1 ARHGAP23 IQSEC2 SPRED3 GRK2 ELMO2 IRS2 PSD4	4.17e-03	391	122	8	2.30.29.30
Domain	-	IQSEC2 PSD4	4.20e-03	15	122	2	1.10.1000.11
Domain	Sec7	IQSEC2 PSD4	4.20e-03	15	122	2	PF01369
Domain	Sec7_alpha_orthog	IQSEC2 PSD4	4.20e-03	15	122	2	IPR023394
Domain	CUB	DCBLD1 CSMD2 CSMD1	4.26e-03	50	122	3	SM00042
Domain	-	DCBLD1 CSMD2 CSMD1	4.76e-03	52	122	3	2.60.120.290
Domain	Sec7	IQSEC2 PSD4	4.78e-03	16	122	2	SM00222
Domain	SEC7	IQSEC2 PSD4	4.78e-03	16	122	2	PS50190
Domain	Sec7_dom	IQSEC2 PSD4	4.78e-03	16	122	2	IPR000904
Domain	CUB	DCBLD1 CSMD2 CSMD1	5.02e-03	53	122	3	PS01180
Domain	CUB_dom	DCBLD1 CSMD2 CSMD1	6.16e-03	57	122	3	IPR000859
Pubmed	Human transcription factor protein interaction networks.	BCL9L RB1 RC3H1 CANX DACH1 ZBTB9 BEND3 RELA ZNF217 ZNF318 ZMIZ1 DBN1 TEAD3 KRR1 MIDEAS TAB3 ZNF503 MED15 RESF1 ZFHX4 CUX1 CPSF7	1.25e-08	1429	128	22	35140242
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	EHBP1 JCAD CASC3 RAPH1 SAMD4B IQSEC2 APC LMTK2 SIK3 TAB3 C6orf132 VPS13D RESF1 IKBKE ELMO2 PHACTR4 IRS2	1.99e-08	861	128	17	36931259
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	EHBP1 RAPH1 ZBTB9 APC BEND3 ZNF217 ZNF318 ZMIZ1 RESF1 ZFHX4 IRS2 CUX1	5.25e-08	418	128	12	34709266
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	RAPH1 AHCTF1 DACH1 BEND3 ZNF318 DBN1 MIDEAS TAB3 MED15 PHACTR4 CTPS1 CUX1 HDLBP	1.33e-07	549	128	13	38280479
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	EHBP1 AHCTF1 CANX APC KIAA1549 ZNF318 TAB3 C6orf132 OCLN	6.14e-07	263	128	9	34702444
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	BCL9L RC3H1 AHCTF1 ZNF207 ZMIZ1 TEAD3 MIDEAS ZNF503 MED15 ALDH16A1 CPSF7	1.10e-06	457	128	11	32344865
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	RC3H1 ZMIZ1 MIDEAS TAB3 ZNF503 MED15 RESF1	1.61e-06	152	128	7	38360978
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	JCAD RB1 APC ZNF217 CEP76 ZNF503 MED15 RESF1 ZFHX4 CUX1	2.35e-06	398	128	10	35016035
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	SF3A1 AHCTF1 NUTM2A DACH1 ZBTB9 BEND3 ZNF207 ZNF318 DBN1 KRR1 MIDEAS NUTM2B CUX1 CPSF7 HDLBP	2.49e-06	954	128	15	36373674
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	MYT1L RNASEH2B RAPH1 DBN1 SIK3 TEAD3 IL22RA1 RNF157 POLR3G NUTM2E SGMS1 NUTM2B CBX6 ALDH16A1 DLG3 CSMD1 DNMT3A	3.29e-06	1242	128	17	30973865
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	EHBP1 JCAD BCL9L DLGAP2 CANX IQSEC2 PER1 APC LMTK2 SYNPO DBN1 TAB3 GRK2 FRRS1L DLG3 HDLBP	4.73e-06	1139	128	16	36417873
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RAPH1 SF3A1 SAMD4B ZNF217 ZNF318 DBN1 SH2D4A PHACTR4 TJAP1 IRS2 CTPS1 AGTPBP1 HDLBP	6.01e-06	774	128	13	15302935
Pubmed	Interaction network of human early embryonic transcription factors.	BCL9L ZBTB9 ZNF217 ZMIZ1 MIDEAS ZNF503 MED15 RESF1 ZFHX4	6.52e-06	351	128	9	38297188
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	BCL9L ZBTB9 ZNF217 TEAD3 MIDEAS MED15 CUX1 CPSF7	7.21e-06	268	128	8	33640491
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	VPS37A CANX SAMD4B IQSEC2 APC ZNF207 PFAS SYNPO ZNF318 SIK3 KRR1 DNMT3A	9.73e-06	689	128	12	36543142
Pubmed	Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice.	HIC1 APC	1.34e-05	2	128	2	21297660
Pubmed	Interaction between nuclear insulin receptor substrate-2 and NF-κB in IGF-1 induces response in breast cancer cells.	RELA IRS2	1.34e-05	2	128	2	21042750
Pubmed	Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome.	PER1 PER3	1.34e-05	2	128	2	11306557
Pubmed	Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein.	APC DLG3	1.34e-05	2	128	2	9188857
Pubmed	Inactivation of conditional Rb by Villin-Cre leads to aggressive tumors outside the gastrointestinal tract.	RB1 APC	1.34e-05	2	128	2	16585182
Pubmed	Loss of CSMD1 or 2 may contribute to the poor prognosis of colorectal cancer patients.	CSMD2 CSMD1	1.34e-05	2	128	2	24408017
Pubmed	Nuclear import of mPER3 in Xenopus oocytes and HeLa cells requires complex formation with mPER1.	PER1 PER3	1.34e-05	2	128	2	16008569
Pubmed	Nuclear factor kappaB is downregulated and correlates with p53 in the Min mouse mucosa during an accelerated tumor growth.	APC RELA	1.34e-05	2	128	2	16049962
Pubmed	vFLIP upregulates IKKε, leading to spindle morphology formation through RelA activation.	RELA IKBKE	1.34e-05	2	128	2	30029010
Pubmed	Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice.	APC IGF2	1.34e-05	2	128	2	15731405
Pubmed	Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon.	RELA IKBKE	1.34e-05	2	128	2	20507904
Pubmed	Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting.	APC IGF2	1.34e-05	2	128	2	16488992
Pubmed	PERIOD1 (PER1) has anti-apoptotic effects, and PER3 has pro-apoptotic effects during cisplatin (CDDP) treatment in human gingival cancer CA9-22 cells.	PER1 PER3	1.34e-05	2	128	2	21459569
Pubmed	The H19 locus acts in vivo as a tumor suppressor.	APC IGF2	1.34e-05	2	128	2	18719115
Pubmed	Impaired protein stability and nuclear localization of NOBOX variants associated with premature ovarian insufficiency.	FOXL2 NOBOX	1.34e-05	2	128	2	27798098
Pubmed	Tumor suppressor pRB functions as a co-repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled histone H4 transcription.	RB1 CUX1	1.34e-05	2	128	2	12891711
Pubmed	[Interaction of two tumor suppressors: Phosphatase CTDSPL and Rb protein].	RB1 CTDSPL	1.34e-05	2	128	2	27414789
Pubmed	A genetic association study of CSMD1 and CSMD2 with cognitive function.	CSMD2 CSMD1	1.34e-05	2	128	2	27890662
Pubmed	NOBOX is a key FOXL2 partner involved in ovarian folliculogenesis.	FOXL2 NOBOX	1.34e-05	2	128	2	24620032
Pubmed	The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.	CSMD2 CSMD1	1.34e-05	2	128	2	21439553
Pubmed	Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice.	APC IGF2	1.34e-05	2	128	2	10706126
Pubmed	Polymorphisms in period genes and bone response to hormone therapy in postmenopausal Korean women.	PER1 PER3	1.34e-05	2	128	2	26624862
Pubmed	PGC-1β promotes enterocyte lifespan and tumorigenesis in the intestine.	APC PPARGC1B	1.34e-05	2	128	2	25288742
Pubmed	A human MAP kinase interactome.	EHBP1 APC SYNPO RELA SIK3 MIDEAS SH2D4A MAP4K5 CUX1 HDLBP	1.35e-05	486	128	10	20936779
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	SF3A1 DACH1 ZBTB9 BEND3 ZNF207 ZNF217 ZNF318 MIDEAS ZNF503 MED15 RESF1 CTPS1 CUX1 CPSF7 HDLBP	1.40e-05	1103	128	15	34189442
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZSWIM8 ARHGAP23 RB1 AHCTF1 ZBTB9 PER1 KIAA1549 BEND3 ZNF318 SIK3 RESF1 ZFHX4 IRS2 CSMD1 AGTPBP1	1.61e-05	1116	128	15	31753913
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	RAPH1 SF3A1 AHCTF1 CANX ZBTB9 ZNF318 DBN1 CRACD PHACTR4 CPSF7	1.91e-05	506	128	10	30890647
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	EHBP1 FTSJ1 SEMA4C ELMO2 MAP4K5 PHACTR4 DLG3 OCLN CTDSPL	2.75e-05	421	128	9	36976175
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	APC BEND3 RELA ZNF318 ZNF865 SEMA4C PHACTR4 TJAP1 DLG3 OCLN GGA1 CUX1	3.17e-05	777	128	12	35844135
Pubmed	A census of human transcription factors: function, expression and evolution.	MYT1L HIC1 AHCTF1 SOX30 KIAA1549 RELA TEAD3 MIDEAS HOXA3 FOXL2 ZFHX4 GLIS1 NOBOX	3.21e-05	908	128	13	19274049
Pubmed	Proliferation of vascular smooth muscle cells under inflammation is regulated by NF-κB p65/microRNA-17/RB pathway activation.	RB1 RELA	4.02e-05	3	128	2	29115381
Pubmed	Expression profiles of PERIOD1, 2, and 3 in peripheral blood mononuclear cells from older subjects.	PER1 PER3	4.02e-05	3	128	2	19013183
Pubmed	Identification of two new members of the CSMD gene family.	CSMD2 CSMD1	4.02e-05	3	128	2	12906867
Pubmed	A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light.	PER1 PER3	4.02e-05	3	128	2	9428527
Pubmed	Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population.	VPS13D CSMD1	4.02e-05	3	128	2	20610895
Pubmed	Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II-Dependent Hypertension in Mice.	PER1 PER3	4.02e-05	3	128	2	26781276
Pubmed	Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei.	PER1 PER3	4.02e-05	3	128	2	9427249
Pubmed	Association between polymorphisms in period genes and bone density in postmenopausal Korean women.	PER1 PER3	4.02e-05	3	128	2	24678593
Pubmed	Impact of insulin-like growth factor 2, insulin-like growth factor receptor 2, insulin receptor substrate 2 genes polymorphisms on susceptibility and clinicopathological features of hepatocellular carcinoma.	IGF2 IRS2	4.02e-05	3	128	2	24656929
Pubmed	Photic entrainment of period mutant mice is predicted from their phase response curves.	PER1 PER3	4.02e-05	3	128	2	20826680
Pubmed	mPeriod2 Brdm1 and other single Period mutant mice have normal food anticipatory activity.	PER1 PER3	4.02e-05	3	128	2	29138421
Pubmed	A time memory engram embedded in a light-entrainable circadian clock.	PER1 PER3	4.02e-05	3	128	2	37951213
Pubmed	Influence of age on clock gene expression in peripheral blood cells of healthy women.	PER1 PER3	4.02e-05	3	128	2	19861640
Pubmed	miR‑27a‑3p upregulation by p65 facilitates cervical tumorigenesis by increasing TAB3 expression and is involved in the positive feedback loop of NF‑κB signaling.	RELA TAB3	4.02e-05	3	128	2	37203408
Pubmed	Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function.	PER1 PER3	4.02e-05	3	128	2	22331899
Pubmed	Ligand-specific antibodies to insulin-like growth factors suppress intestinal polyp formation in Apc+/- mice.	APC IGF2	4.02e-05	3	128	2	20103605
Pubmed	[VIGILIN involves in regulation of imprinting gene IGF2 and H19 in human hepatocellular carcinoma cell].	IGF2 HDLBP	4.02e-05	3	128	2	19950580
Pubmed	Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes.	PER1 PER3	4.02e-05	3	128	2	15031135
Pubmed	RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer.	RNASEH2B RB1	4.02e-05	3	128	2	35179959
Pubmed	Period determination in the food-entrainable and methamphetamine-sensitive circadian oscillator(s).	PER1 PER3	4.02e-05	3	128	2	22891330
Pubmed	Epithelial IGF1R is dispensable for IGF2 mediated enhanced intestinal adaptation in retinoblastoma-deficient mice.	RB1 IGF2	4.02e-05	3	128	2	28343662
Pubmed	The Prosurvival IKK-Related Kinase IKKε Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine.	APC IKBKE	4.02e-05	3	128	2	26980769
Pubmed	Period Family of Clock Genes as Novel Predictors of Survival in Human Cancer: A Systematic Review and Meta-Analysis.	PER1 PER3	4.02e-05	3	128	2	32849922
Pubmed	Expression of the proliferating cell nuclear antigen and protein products of tumour suppressor genes in the human foetal testis.	RB1 APC	4.02e-05	3	128	2	14871261
Pubmed	The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.	NUTM2E NUTM2B	4.02e-05	3	128	2	26542179
Pubmed	IGF-2 mediates intestinal mucosal hyperplasia in retinoblastoma protein (Rb)-deficient mice.	RB1 IGF2	4.02e-05	3	128	2	23845628
Pubmed	Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway.	PER1 PER3	4.02e-05	3	128	2	29269828
Pubmed	Association of P16-RBSP3 inactivation with phosphorylated RB1 overexpression in basal-parabasal layers of normal cervix unchanged during CACX development.	RB1 CTDSPL	4.02e-05	3	128	2	27458253
Pubmed	The complex relationship between the light-entrainable and methamphetamine-sensitive circadian oscillators: evidence from behavioral studies of Period-mutant mice.	PER1 PER3	4.02e-05	3	128	2	23869717
Pubmed	The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.	NUTM2A NUTM2B	4.02e-05	3	128	2	22456610
Pubmed	Functional polymorphisms of circadian negative feedback regulation genes are associated with clinical outcome in hepatocellular carcinoma patients receiving radical resection.	PER1 PER3	4.02e-05	3	128	2	25344870
Pubmed	Methylation of the retinoblastoma tumor suppressor by SMYD2.	RB1 L3MBTL1	4.02e-05	3	128	2	20870719
Pubmed	Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock.	PER1 PER3	4.02e-05	3	128	2	11395012
Pubmed	Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity.	PER1 PER3	4.02e-05	3	128	2	12032351
Pubmed	Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers.	PER1 PER3	4.02e-05	3	128	2	15790588
Pubmed	Aberrant expression of Per1, Per2 and Per3 and their prognostic relevance in non-small cell lung cancer.	PER1 PER3	4.02e-05	3	128	2	25550826
Pubmed	Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a.	APC DNMT3A	4.02e-05	3	128	2	24837369
Pubmed	A light-independent oscillatory gene mPer3 in mouse SCN and OVLT.	PER1 PER3	4.02e-05	3	128	2	9707434
Pubmed	Intracellular calcium mobilization induces period genes via MAP kinase pathways in NIH3T3 cells.	PER1 PER3	4.02e-05	3	128	2	11959112
Pubmed	Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin.	APC IGF2	4.02e-05	3	128	2	22800756
Pubmed	Comparing expression levels of PERIOD genes PER1, PER2 and PER3 in chronic insomnia patients and medical staff working in the night shift.	PER1 PER3	4.02e-05	3	128	2	32805476
Pubmed	Vigilin interacts with CTCF and is involved in the maintenance of imprinting of IGF2 through a novel RNA-mediated mechanism.	IGF2 HDLBP	4.02e-05	3	128	2	29157910
Pubmed	Nuclear export of mammalian PERIOD proteins.	PER1 PER3	4.02e-05	3	128	2	11591712
Pubmed	miR-155-5p inhibition promotes the transition of bone marrow mesenchymal stem cells to gastric cancer tissue derived MSC-like cells via NF-κB p65 activation.	RELA IKBKE	4.02e-05	3	128	2	26934326
Pubmed	Aberrant granulosa cell-fate related to inactivated p53/Rb signaling contributes to granulosa cell tumors and to FOXL2 downregulation in the mouse ovary.	RB1 FOXL2	4.02e-05	3	128	2	31745296
Pubmed	Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon.	RB1 APC	4.02e-05	3	128	2	18832169
Pubmed	The role of phosphorylation and degradation of hPER protein oscillation in normal human fibroblasts.	PER1 PER3	4.02e-05	3	128	2	14712925
Pubmed	Apc gene suppresses intracranial aneurysm formation and rupture through inhibiting the NF-κB signaling pathway mediated inflammatory response.	APC RELA	4.02e-05	3	128	2	30808715
Pubmed	IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65.	RELA IKBKE	4.02e-05	3	128	2	17003035
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	VPS37A DACH1 ZNF207 SYNPO ZNF318 DBN1 MED15 RESF1 HDLBP	4.15e-05	444	128	9	34795231
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	JCAD BCL9L SAMD4B APC KIAA1549 DBN1 TEAD3 SNX18 IRS2	4.30e-05	446	128	9	24255178
Pubmed	Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.	EHBP1 LMTK2 IGF2	4.52e-05	19	128	3	19767753
Pubmed	Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.	MLANA RESF1 PHACTR4 IRS2 GGA1	5.61e-05	110	128	5	37219487
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CASC3 DLGAP2 CANX IQSEC2 APC SYNPO ZNF318 GRIN2D DBN1 SIK3 TJAP1 DLG3 CUX1	5.85e-05	963	128	13	28671696
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	EHBP1 SF3A1 AHCTF1 CANX APC MAP4K5 PHACTR4 IRS2 OCLN CTPS1 HDLBP	6.50e-05	708	128	11	39231216
Interaction	YWHAG interactions	EHBP1 JCAD CASC3 RAPH1 ARHGAP23 RC3H1 SAMD4B IQSEC2 APC LMTK2 SYNPO SIK3 KRR1 TAB3 C6orf132 CRACD VPS13D ELMO2 MAP4K5 PHACTR4 IRS2 CTPS1 PSD4	2.63e-06	1248	126	23	int:YWHAG
Interaction	PHF21A interactions	EHBP1 ZBTB9 APC BEND3 ZNF217 ZNF318 ZMIZ1 RESF1 ZFHX4 IRS2 PKN3	1.05e-05	343	126	11	int:PHF21A
Interaction	YAP1 interactions	JCAD BCL9L MLANA RB1 SF3A1 AHCTF1 DACH1 BEND3 RELA ZNF318 DBN1 TEAD3 MIDEAS TAB3 MED15 TULP4 IKBKE CUX1 CPSF7 HDLBP	1.48e-05	1095	126	20	int:YAP1
Cytoband	10q22.3	ZMIZ1 NUTM2E NUTM2B	2.41e-04	43	128	3	10q22.3
Cytoband	Ensembl 112 genes in cytogenetic band chr10q22	ZSWIM8 ZMIZ1 ZNF503 NUTM2E NUTM2B	3.06e-04	208	128	5	chr10q22
Cytoband	1p36.23	PER3 SLC45A1	6.87e-04	14	128	2	1p36.23
Cytoband	10q11.2	RBP3 SGMS1	6.87e-04	14	128	2	10q11.2
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	APC LMTK2 SH2D4A PHACTR4 DLG3 CSMD1 OCLN	9.18e-06	181	74	7	694
GeneFamily	X-linked mental retardation\|Angiotensin receptors	IQSEC2 FTSJ1 DLG3	1.33e-03	53	74	3	103
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RAPH1 ARHGAP23 GRK2 IRS2 PSD4	1.56e-03	206	74	5	682
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	MYT1L TMEM185B RAPH1 ARHGAP23 NUTM2A APC KIAA1549 ZNF318 ZMIZ1 SIK3 CSMD2 RNF157 PPARGC1B ZFHX4 TULP4 DLG3 CSMD1 AGTPBP1	5.90e-06	1106	126	18	M39071
CoexpressionAtlas	gudmap_RNAseq_e11.5_Ureteric_stalks_2500_K0	CCNJL EFS DACH1 ZBTB9 DCBLD1 BEND3 PFAS ZNF217 TEAD3 ZNF865 SPRED3 ZNF503 CRACD STRADB IGF2 L3MBTL1 ALDH16A1 DLG3 IRS2 GGA1 PKN3	1.30e-05	1275	123	21	gudmap_RNAseq_e11.5_Ureteric_stalks_2500_K0
Disease	Malignant neoplasm of breast	EHBP1 HIC1 RAPH1 RB1 PER1 RELA ZNF318 GRIN2D ZMIZ1 DBN1 SIK3 HOXA3 PPARGC1B PER3 OCLN GGA1 CUX1 DNMT3A HDLBP	1.56e-07	1074	126	19	C0006142
Disease	non-syndromic X-linked intellectual disability (implicated_via_orthology)	IQSEC2 FTSJ1 DLG3	6.27e-06	9	126	3	DOID:0050776 (implicated_via_orthology)
Disease	Colorectal Carcinoma	EFS SF3A1 RBP3 PER1 APC ZNF217 ZMIZ1 IGF2 FOXL2 DLG3 CUX1 AGTPBP1	4.93e-05	702	126	12	C0009402
Disease	mannonate measurement	CRYL1 MAP4K5	5.41e-05	3	126	2	EFO_0800971
Disease	Gastrointestinal Neoplasms	HIC1 APC	1.08e-04	4	126	2	C0017185
Disease	Malignant neoplasm of gastrointestinal tract	HIC1 APC	1.08e-04	4	126	2	C0685938
Disease	triacylglycerol 48:3 measurement	DACH1 MAP4K5 CSMD1	1.10e-04	22	126	3	EFO_0010406
Disease	Endometrial Stromal Sarcoma	NUTM2A NUTM2B	1.79e-04	5	126	2	C0206630
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	2.68e-04	6	126	2	C0334488
Disease	Hepatoblastoma	APC IGF2	2.68e-04	6	126	2	C0206624
Disease	Mental Retardation, X-Linked 1	IQSEC2 FTSJ1 DLG3	3.44e-04	32	126	3	C2931498
Disease	Pseudo-TORCH syndrome	RNASEH2B OCLN	3.75e-04	7	126	2	C3489725
Disease	Premature ovarian failure	FOXL2 NOBOX	3.75e-04	7	126	2	cv:C0085215
Disease	calcium measurement	VPS37A ZNF318 SH2D2A ZMIZ1 SIK3 SEMA4C MAP4K5 IRS2 PKN3 DNMT3A	3.75e-04	628	126	10	EFO_0004838
Disease	prostate cancer (implicated_via_orthology)	CYP51A1 APC HDLBP	3.78e-04	33	126	3	DOID:10283 (implicated_via_orthology)
Disease	triacylglycerol 52:5 measurement	DACH1 SIK3 MAP4K5	4.50e-04	35	126	3	EFO_0010417
Disease	triacylglycerol 52:4 measurement	DACH1 SIK3 MAP4K5	4.90e-04	36	126	3	EFO_0010416
Disease	triacylglycerol 50:3 measurement	SIK3 MAP4K5 CSMD1	6.21e-04	39	126	3	EFO_0010410
Disease	cholesteryl esters to total lipids in small LDL percentage	SIK3 MAP4K5 SOAT2	7.73e-04	42	126	3	EFO_0022255
Disease	response to carboplatin, response to antineoplastic agent	CRYL1 CSMD1	7.96e-04	10	126	2	GO_0097327, GO_0097328
Disease	level of Triacylglycerol (51:3) in blood serum	SIK3 MAP4K5	7.96e-04	10	126	2	OBA_2045163
Disease	platelet crit	JCAD HIC1 DACH1 ZNF318 SH2D2A TULP4 CBX6 MAP4K5 IRS2 CTPS1 CUX1 PKN3	7.97e-04	952	126	12	EFO_0007985
Disease	Childhood Medulloblastoma	HIC1 APC IRS2	8.28e-04	43	126	3	C0278510
Disease	Melanotic medulloblastoma	HIC1 APC IRS2	8.28e-04	43	126	3	C1275668
Disease	Medullomyoblastoma	HIC1 APC IRS2	8.28e-04	43	126	3	C0205833
Disease	Desmoplastic Medulloblastoma	HIC1 APC IRS2	8.28e-04	43	126	3	C0751291
Disease	Adult Medulloblastoma	HIC1 APC IRS2	8.28e-04	43	126	3	C0278876
Disease	level of Ceramide (d40:1) in blood serum	SIK3 MAP4K5	9.70e-04	11	126	2	OBA_2045185
Disease	level of Diacylglycerol (18:1_18:1) in blood serum	SIK3 MAP4K5	9.70e-04	11	126	2	OBA_2045170
Disease	free androgen index	CASC3 ZNF318 ZMIZ1 ZFHX4 MAP4K5 CUX1 PKN3	1.16e-03	374	126	7	EFO_0007005
Disease	phosphatidylcholine 34:4 measurement	DACH1 MAP4K5	1.16e-03	12	126	2	EFO_0010378
Disease	level of Diacylglycerol (18:1_18:2) in blood serum	SIK3 MAP4K5	1.16e-03	12	126	2	OBA_2045171
Disease	hepatocellular carcinoma (biomarker_via_orthology)	RB1 PFAS IGF2 DNMT3A	1.21e-03	108	126	4	DOID:684 (biomarker_via_orthology)
Disease	Medulloblastoma	HIC1 APC IRS2	1.29e-03	50	126	3	C0025149
Disease	Mental Retardation, X-Linked Nonsyndromic	FTSJ1 DLG3	1.37e-03	13	126	2	C3501611
Disease	Schizophrenia	MYT1L DLGAP2 APC RELA GRIN2D DBN1 CSMD2 MED15 IGF2 DLG3 CSMD1	1.45e-03	883	126	11	C0036341
Disease	health literacy measurement	DLGAP2 CSMD1 GGA1	1.52e-03	53	126	3	EFO_0010104
Disease	triacylglycerol 46:2 measurement	MAP4K5 CSMD1	1.59e-03	14	126	2	EFO_0010402
Disease	triacylglycerol 52:1 measurement	MAP4K5 CSMD1	1.59e-03	14	126	2	EFO_0010413
Disease	triacylglycerol 52:2 measurement	SIK3 MAP4K5 CSMD1	1.70e-03	55	126	3	EFO_0010414
Disease	body surface area	ZBTB9 PER1 ZMIZ1 IGF2 MAP4K5 CTPS1 CTDSPL DNMT3A PSD4	1.80e-03	643	126	9	EFO_0022196
Disease	triacylglycerol 52:3 measurement	SIK3 MAP4K5	1.83e-03	15	126	2	EFO_0010415
Disease	level of Triacylglycerol (53:3) in blood serum	SIK3 MAP4K5	1.83e-03	15	126	2	OBA_2045165
Disease	triacylglycerol 50:5 measurement	DACH1 MAP4K5	2.09e-03	16	126	2	EFO_0010412
Disease	Lipidemias	APC PPARGC1B	2.36e-03	17	126	2	C1706412
Disease	triacylglycerol 48:1 measurement	MAP4K5 CSMD1	2.36e-03	17	126	2	EFO_0010404
Disease	Hyperlipidemia	APC PPARGC1B	2.36e-03	17	126	2	C0020473
Disease	Adrenocortical carcinoma	RB1 IGF2	2.65e-03	18	126	2	C0206686
Disease	response to methotrexate, juvenile idiopathic arthritis	ZMIZ1 CSMD1	2.95e-03	19	126	2	EFO_0002609, GO_0031427
Disease	laryngeal squamous cell carcinoma (is_marker_for)	RELA FOXL2	2.95e-03	19	126	2	DOID:2876 (is_marker_for)
Disease	susceptibility to mononucleosis measurement	MYT1L DLGAP2 ZBTB9	3.24e-03	69	126	3	EFO_0008403
Disease	rheumatoid arthritis (is_marker_for)	TAB3 IGF2 GRK2	3.24e-03	69	126	3	DOID:7148 (is_marker_for)
Disease	triacylglycerol 46:1 measurement	MAP4K5 CSMD1	3.27e-03	20	126	2	EFO_0010401
Disease	ectonucleoside triphosphate diphosphohydrolase 5 measurement	PTGR2 MIDEAS	3.60e-03	21	126	2	EFO_0008115
Disease	advanced glycosylation end product-specific receptor ligand measurement	JCAD PRRT1B	3.60e-03	21	126	2	EFO_0010762
Disease	Splenomegaly	APC OCLN	3.95e-03	22	126	2	C0038002
Disease	triacylglycerol 48:2 measurement	MAP4K5 CSMD1	3.95e-03	22	126	2	EFO_0010405
Disease	triacylglycerol 54:6 measurement	SIK3 MAP4K5	3.95e-03	22	126	2	EFO_0010424
Disease	Major Depressive Disorder	MYT1L RAPH1 IKBKE DLG3 CUX1	3.96e-03	243	126	5	C1269683

Protein segments in the cluster

Peptide	Gene	Start	Entry
FNPYLTGPFPKLPPS	ERFL	231	A0A1W2PQ73
VILSPNYPQPYPPGK	CSMD1	1461	Q96PZ7
ILSPNYPEPYPPGKE	CSMD2	1456	Q7Z408
AFALYKPPPAPLVAP	CBX6	231	O95503
EFDPPKVYPPVPAEK	DNMT3A	616	Q9Y6K1
ERPFYPPTLVSNLPP	ALDH16A1	376	Q8IZ83
KPTKPSVPPLTPEQY	CUX1	921	P39880
PTPTQVLFQPPAYPA	CCNJL	321	Q8IV13
YTNYKKTPPPVPPRT	DLGAP2	606	Q9P1A6
PPVAEQPKPLYPYRT	CEP76	441	Q8TAP6
PPPFKEPILERPYGV	AGTPBP1	656	Q9UPW5
PLPGKPVYSTPSPVE	DACH1	166	Q9UI36
VFLQKYPPPLIPPRG	GRK2	461	P25098
PIPHIPRSPYKFPSS	RB1	781	P06400
PIPIEIPPAAVPSYV	RC3H1	691	Q5TC82
PYTSLVPPLSPQPKI	RAPH1	601	Q70E73
PPAKKQPAFPASYIP	RAPH1	811	Q70E73
DKPPSVLPYFNRPPS	CPSF7	216	Q8N684
LESPPPYRPDEFKPN	OCLN	6	Q16625
GPEPTFKPYLPPKRA	KCTD19	711	Q17RG1
PLFQSPQPKLPYLPT	NOBOX	526	O60393
PQPKLPYLPTFPFSM	NOBOX	531	O60393
LPFPASQYIPPQPSI	KIAA1549	1666	Q9HCM3
LVVPSPDFPVPSPYL	BEND3	706	Q5T5X7
PPPLYYTNLTQEKPP	MAP10	301	Q9P2G4
PPAYEKLSAEQSPPP	MLANA	101	Q16655
SVPYEPQSPPPFSKP	HOXA3	286	O43365
PAAYKEPPLALPSLP	HIC1	276	Q14526
PPPPEEYKSQRPVSN	IQSEC2	1186	Q5JU85
KPLPASYPAEPREPQ	JCAD	986	Q9P266
PPIAPYPSPTRKDLL	IKBKE	666	Q14164
PTKARAPLPSAYVPP	HMGN2P46	51	Q86SG4
PFPAVVQPYPLPVFS	PER1	876	O15534
VPSQAPYLVPAFPLP	PER3	791	P56645
KPLTPPQDYPDPDNF	L3MBTL1	476	Q9Y468
PEKPDPAQKPPYSYV	FOXL2	46	P58012
SKIPKYPTNPPGQLP	MDM1	616	Q8TC05
PSVPPLELSVPADYP	MED15	716	Q96RN5
QIPQLPAPPKIYFPI	MICOS13	66	Q5XKP0
TVKKEYTPFPPPQPE	KRR1	261	Q13601
YTPFPPPQPESQIDK	KRR1	266	Q13601
PSLQTSKYFSPPPPA	LMTK2	1441	Q8IWU2
TFPLPPPRPKNVIFE	GGA1	156	Q9UJY5
APPPVFYNKPPEIDI	DBN1	616	Q16643
PRTPPFPAKTFQVVP	PHACTR4	356	Q8IZ21
APSPPRDKPAPYTFT	OCR1	26	Q9BZK8
PYEAAIPPAPVVPLL	ACP4	381	Q9BZG2
EYPLPPEPKSPGEYI	IRS2	906	Q9Y4H2
LTFPRSFKVPPPTPV	C6orf132	296	Q5T0Z8
FPPEDTPFLYPTRIP	HSPBAP1	196	Q96EW2
RPYVEVFSPSPPKLP	DNAH6	136	Q9C0G6
PPPQQLLAPTYFSAP	CASC3	611	O15234
EAPPPIPKEPSSYDF	ELMO2	701	Q96JJ3
PIPSPPAKYLLPEVT	CTDSPL	86	O15194
YPFPTAPPVDPFAKI	FRRS1L	81	Q9P0K9
PSFLVPSLPYPPQKV	CRACD	796	Q6ZU35
PVAEYFSKPNSPPRP	C4orf17	311	Q53FE4
PAGVKSPPYIFSPIP	CYP51A1	61	Q16850
TPPTVLPDNFPRYPV	IGF2	96	P01344
PQQPPTAPPSGLKKY	BCL9L	451	Q86UU0
APPSSPKVTYKAPVP	CANX	51	P27824
APYDVPLTPKPPAEL	EFS	186	O43281
ESKVSYPAPPQVPPT	DLG3	351	Q92796
PFYEPKSTPPPNNLV	EHBP1	371	Q8NDI1
PFSDPVPYLEVPVPR	IDUA	631	P35475
ERSFELPPYTPPPIL	MIDEAS	646	Q6PJG2
PPSYAPQVTPEAQFP	IL22RA1	361	Q8N6P7
FNKFIPLSEPAPVPP	COPS8	176	Q99627
PVNPPYYIPLVELVP	CRYL1	146	Q9Y2S2
PSPIVYSLPAPELPE	AHCTF1	1086	Q8WYP5
QPFPTLPSKPSYPPF	GLIS1	486	Q8NBF1
LPLAPPEPEYATPIV	DCBLD1	591	Q8N8Z6
PISPPSPLTPKYGSF	SLC45A1	371	Q9Y2W3
PLPPKPRISSYPEDN	MAP4K5	391	Q9Y4K4
PKPPRLYLPQEPTSE	PKN3	511	Q6P5Z2
PPAPEVVKQPVYLPS	NUTM2A	441	Q8IVF1
PPAPEVVKQPVYLPS	NUTM2B	441	A6NNL0
PPAPEVVKQPVYLPS	NUTM2E	441	B1AL46
PPPCPVFYPEKQEIT	SMG8	931	Q8ND04
KYSPDNYTPPVPPPV	RSPH4A	651	Q5TD94
PYAAPPPQEPVKTLR	RNF157	71	Q96PX1
AKPQLPPEVYTIPVP	SH2D2A	251	Q9NP31
SQPKPPFSVNPVYIT	TAB3	416	Q8N5C8
TQSPGKYVPPPPKLN	TMEM185B	331	Q9H7F4
TLPPLYPKSQPPFLH	RESF1	11	Q9HCM1
PEPTKQPPYQLRPSL	SYNPO	801	Q8N3V7
CTPPFPVPIYKPHSI	PSD4	316	Q8NDX1
PPTTPPYKPTEEDPF	PPARGC1B	606	Q86YN6
HPEFLSRPIKPSPPY	CTPS1	526	P17812
KVPPLDQFPTFPPSA	SIK3	921	Q9Y2K2
KPPFPPIPFFLAIYL	OPRPN	121	Q99935
VYPLELPKEPTSPPF	SEMA4C	706	Q9C0C4
LPPAPAPDEYLVSPI	SF3A1	401	Q15459
FPPYPKPGEISNDPI	SGCE	71	O43556
AVQDPSLPVYPALPP	SOX30	496	O94993
AIQSYPSQDKPLPPP	SOAT2	71	O75908
LPPPVARKPSQLPVY	APC	1601	P25054
YENSTPPYKDLPPKP	CLEC17A	26	Q6ZS10
PLPAFEKLNPYPTPS	TJAP1	306	Q5JTD0
LEPQPYLKAPGLPPY	PRR22	116	Q8IZ63
VQVTKINPPPPYPGT	TULP4	826	Q9NRJ4
PPLVLNFELPPDYPS	RNF14	71	Q9UBS8
PEYPAEKPKQSDPSP	ZFHX4	2361	Q86UP3
PYLLPPDPPTTDSEK	ZNF865	491	P0CJ78
PPPAVPSPEELTYLI	RBP3	716	P10745
YLKLPEPSASLPNPP	RNASEH2B	231	Q5TBB1
TEAKDPPAVENYPPP	SAMD4B	436	Q5PRF9
SIPEPPPICYPRKTY	ARHGAP23	181	Q9P227
VAPPASFKPPPDAFQ	SNX18	91	Q96RF0
YPPLLPFTGIPEPSE	SPRED3	191	Q2MJR0
PSYCLPPTFPKASVP	PFAS	1041	O15067
FAQPAYPIQPPLPPT	TEAD3	181	Q99594
PPLPPKPQFLNSGAY	SH2D4A	286	Q9H788
PPKEVQPPLPDTFFD	SGMS1	161	Q86VZ5
VLKPPPLFPDTDYKP	POLR3G	31	O15318
ELPAPPALPPKIFYI	ZBTB9	271	Q96C00
KYTPPTQPPISPPYQ	FTSJ1	261	Q9UET6
PRPAVFPVPSSAYPQ	ZSWIM8	1536	A7E2V4
PATTTEPPKPTFPAY	ZNF207	311	O43670
SPYKPGQTVFPLPPA	ZNF503	341	Q96F45
PQDCVYPSQALPPKP	ZNF217	956	O75362
PAYNKPSISLPPVLP	STRADB	386	Q9C0K7
DPPTYKDAFPPLPEK	HDLBP	36	Q00341
RSSASVPKPAPQPYP	RELA	336	Q04206
VPKPAPQPYPFTSSL	RELA	341	Q04206
DPKAAPLLYPPFPQV	PRRT1B	111	A0A1B0GWB2
KDVPYPPPLSPAIEA	PTGR2	261	Q8N8N7
PPSPVDPYLLTKNSP	ZNF318	696	Q5VUA4
PQFPQEKPVISVYPP	VPS37A	71	Q8NEZ2
IPPYLSPSQDVKPPF	ZMIZ1	526	Q9ULJ6
DEYKTPLATPPNTPP	VPS13D	766	Q5THJ4
KDYPLTPPPSPTVDE	VPS13D	1756	Q5THJ4
YPGEVTIPSPKPKYP	MYT1L	856	Q9UL68
AAQPPQKPPPSYFAI	GRIN2D	996	O15399