Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein binding involved in heterotypic cell-cell adhesion

IZUMO1 IZUMO1R

1.44e-0418202GO:0086080
GeneOntologyBiologicalProcesssperm-egg recognition

IZUMO1 IZUMO1R ATP8B3

3.81e-0565213GO:0035036
GeneOntologyBiologicalProcesscell-cell recognition

IZUMO1 IZUMO1R ATP8B3

1.08e-0492213GO:0009988
Domain7tm_1

OR10G6 GALR2 HRH3 OR2T6

5.22e-03677204PF00001
DomainG_PROTEIN_RECEP_F1_1

OR10G6 GALR2 HRH3 OR2T6

5.44e-03685204PS00237
DomainG_PROTEIN_RECEP_F1_2

OR10G6 GALR2 HRH3 OR2T6

5.61e-03691204PS50262
DomainGPCR_Rhodpsn

OR10G6 GALR2 HRH3 OR2T6

5.64e-03692204IPR000276
Pubmed

Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization.

IZUMO1 IZUMO1R

3.82e-07222227309808
Pubmed

Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex.

IZUMO1 IZUMO1R

3.82e-07222227309818
Pubmed

Alternative splicing of the Izumo1 gene ensures triggering gamete fusion in mice.

IZUMO1 IZUMO1R

3.82e-07222230816314
Pubmed

Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilization.

IZUMO1 IZUMO1R

3.82e-07222225209248
Pubmed

Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice.

IZUMO1 IZUMO1R

3.82e-07222226568141
Pubmed

Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization.

IZUMO1 IZUMO1R

3.82e-07222227416963
Pubmed

Genetic diversity in the IZUMO1-JUNO protein-receptor pair involved in human reproduction.

IZUMO1 IZUMO1R

3.82e-07222234879103
Pubmed

Unveiling a novel function of CD9 in surface compartmentalization of oocytes.

IZUMO1 IZUMO1R

1.15e-06322232665248
Pubmed

Juno is the egg Izumo receptor and is essential for mammalian fertilization.

IZUMO1 IZUMO1R

1.15e-06322224739963
Pubmed

N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.

ADNP2 AJUBA PCNX1

3.38e-0421722334048709
Diseasephosphoglycerides measurement

IZUMO1 TDRD15

4.35e-0448192EFO_0022291
Diseasetriglycerides in IDL measurement

IZUMO1 TDRD15

6.36e-0458192EFO_0022149
Diseasetriglycerides in very small VLDL measurement

IZUMO1 TDRD15

8.72e-0468192EFO_0022144
Diseasetriglyceride measurement, low density lipoprotein cholesterol measurement

IZUMO1 TDRD15

5.05e-03166192EFO_0004530, EFO_0004611
DiseaseHMG CoA reductase inhibitor use measurement

TDRD15 PCNX1

6.50e-03189192EFO_0009932

Protein segments in the cluster

PeptideGeneStartEntry
CFPLDGHLLCHGCHM

AJUBA

511

Q96IF1
CEAPNSRMHHFVGCL

ATP8B3

306

O60423
LIHHLLMHGLGCLFC

ADNP2

761

Q6IQ32
LMHGLGCLFCPCTFH

ADNP2

766

Q6IQ32
MNAIVALCHFCELHG

FLCN

1

Q8NFG4
LFHCGLLMPGCRKHF

IZUMO1R

76

A6ND01
CCEPGHIPHMLSFNA

PCNX1

1641

Q96RV3
HFFCEAPTMLRLACG

OR2T6

176

Q8NHC8
GHLMCAGCFIHLLAD

CYHR1

86

Q6ZMK1
LMDHGVPCHYTCFLL

CCNYL3

261

P0C7X3
VAALFCLCWMPHHAL

GALR2

241

O43603
LVCLGMLCHSHAFAP

CDH11

11

P55287
HIMLFGCTLAFPECI

CORIN

186

Q9Y5Q5
LLMIIRAACHGHCVP

HRH3

376

Q9Y5N1
GYAPVLDCHMAHIAC

EEF1A1P5

356

Q5VTE0
MGPHFTLLCAALAGC

IZUMO1

1

Q8IYV9
LQHAAGLLHAMCTLC

SCAPER

1136

Q9BY12
LHRPMCLFLCHLSFL

OR10G6

76

Q8NH81
FFMHHPDGCALSTDC

TRMT44

721

Q8IYL2
FCELPALAMCCSLAH

TDRD15

586

B5MCY1
ALAMCCSLAHIFPVE

TDRD15

591

B5MCY1
GHMLCFLNCHLPAHM

INPP5J

551

Q15735
PLHCACGAAFMDFLL

TLR9

761

Q9NR96
MPSGLCAHLFGLSDC

SERINC4

96

A6NH21
GGFTHVPCFLHCLNM

ZBED6

576

P86452