Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	EPHB3 HK2 CRIM1 PDGFRA MAP3K14 DGKD DGKH CDC42BPB ITK PTK2B MAP4K5 CCL2 EIF2AK4 ATM	9.21e-06	709	98	14	GO:0016773
GeneOntologyMolecularFunction	ATP-dependent activity	DDX19B DNHD1 ATP6V0B RNF213 ATP10B FANCM MSH6 ATP2C1 MACF1 ATP13A3 MYO15A DNAH6 SMC1B	9.47e-06	614	98	13	GO:0140657
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	EPHB3 HK2 CRIM1 PDGFRA MAP3K14 DGKD DGKH CDC42BPB ITK PTK2B MAP4K5 CCL2 EIF2AK4 ATM POLK MAB21L1	1.25e-05	938	98	16	GO:0016772
GeneOntologyMolecularFunction	kinase activity	EPHB3 HK2 CRIM1 PDGFRA MAP3K14 DGKD DGKH CDC42BPB ITK PTK2B MAP4K5 CCL2 EIF2AK4 ATM	2.12e-05	764	98	14	GO:0016301
GeneOntologyMolecularFunction	protein kinase activity	EPHB3 CRIM1 PDGFRA MAP3K14 CDC42BPB ITK PTK2B MAP4K5 CCL2 EIF2AK4 ATM	1.73e-04	600	98	11	GO:0004672
GeneOntologyMolecularFunction	ATP hydrolysis activity	DDX19B RNF213 ATP10B FANCM ATP2C1 MACF1 ATP13A3 DNAH6 SMC1B	3.20e-04	441	98	9	GO:0016887
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP6V0B ATP2C1 ATP13A3	7.28e-04	36	98	3	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP6V0B ATP2C1 ATP13A3	7.28e-04	36	98	3	GO:0015662
GeneOntologyMolecularFunction	protein tyrosine kinase activity	EPHB3 CRIM1 PDGFRA ITK PTK2B	7.44e-04	145	98	5	GO:0004713
GeneOntologyMolecularFunction	pyrophosphatase activity	DDX19B GTPBP4 MTG1 RNF213 ATP10B FANCM ATP2C1 MACF1 PLPP4 ATP13A3 DNAH6 SMC1B	8.23e-04	839	98	12	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	DDX19B GTPBP4 MTG1 RNF213 ATP10B FANCM ATP2C1 MACF1 PLPP4 ATP13A3 DNAH6 SMC1B	8.32e-04	840	98	12	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	DDX19B GTPBP4 MTG1 RNF213 ATP10B FANCM ATP2C1 MACF1 PLPP4 ATP13A3 DNAH6 SMC1B	8.32e-04	840	98	12	GO:0016818
GeneOntologyMolecularFunction	lipid kinase activity	DGKD DGKH ATM	1.07e-03	41	98	3	GO:0001727
GeneOntologyMolecularFunction	ATP-dependent diacylglycerol kinase activity	DGKD DGKH	1.27e-03	11	98	2	GO:0004143
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	DDX19B GTPBP4 MTG1 RNF213 ATP10B FANCM ATP2C1 MACF1 ATP13A3 DNAH6 SMC1B	1.46e-03	775	98	11	GO:0017111
Domain	CTNNB1_binding	TCF7L2 TCF7L1	1.66e-04	4	99	2	PF08347
Domain	TCF/LEF	TCF7L2 TCF7L1	1.66e-04	4	99	2	IPR024940
Domain	CTNNB1-bd_N	TCF7L2 TCF7L1	1.66e-04	4	99	2	IPR013558
Domain	Mab-21-like_1/2	MAB21L2 MAB21L1	2.75e-04	5	99	2	IPR020950
Domain	Kinase-like_dom	EPHB3 PDGFRA MAP3K14 CDC42BPB ITK PTK2B MAP4K5 MACF1 EIF2AK4 ATM	6.01e-04	542	99	10	IPR011009
Domain	ATPase_P-typ_P_site	ATP10B ATP2C1 ATP13A3	9.08e-04	36	99	3	IPR018303
Domain	P_typ_ATPase	ATP10B ATP2C1 ATP13A3	9.08e-04	36	99	3	IPR001757
Domain	ATPASE_E1_E2	ATP10B ATP2C1 ATP13A3	9.08e-04	36	99	3	PS00154
Domain	Protein_kinase_ATP_BS	EPHB3 PDGFRA MAP3K14 CDC42BPB ITK PTK2B MAP4K5 EIF2AK4	9.17e-04	379	99	8	IPR017441
Domain	ATPase_P-typ_transduc_dom_A	ATP10B ATP2C1 ATP13A3	9.85e-04	37	99	3	IPR008250
Domain	E1-E2_ATPase	ATP10B ATP2C1 ATP13A3	9.85e-04	37	99	3	PF00122
Domain	DAGK_acc	DGKD DGKH	1.22e-03	10	99	2	PF00609
Domain	Diacylglycerol_kin_accessory	DGKD DGKH	1.22e-03	10	99	2	IPR000756
Domain	DAGKa	DGKD DGKH	1.22e-03	10	99	2	SM00045
Domain	Tyr_kinase_cat_dom	EPHB3 PDGFRA ITK PTK2B	1.23e-03	88	99	4	IPR020635
Domain	TyrKc	EPHB3 PDGFRA ITK PTK2B	1.23e-03	88	99	4	SM00219
Domain	fn3	EPHB3 COL12A1 OBSL1 UMODL1 MYOM2	1.71e-03	162	99	5	PF00041
Domain	PROTEIN_KINASE_TYR	EPHB3 PDGFRA ITK PTK2B	1.77e-03	97	99	4	PS00109
Domain	Tyr_kinase_AS	EPHB3 PDGFRA ITK PTK2B	1.77e-03	97	99	4	IPR008266
Domain	Mab-21	MAB21L2 MAB21L1	1.77e-03	12	99	2	PF03281
Domain	Mab-21	MAB21L2 MAB21L1	1.77e-03	12	99	2	SM01265
Domain	Quinoprot_gluc/sorb_DH	MED16 EML2	1.77e-03	12	99	2	IPR011041
Domain	Mab-21_dom	MAB21L2 MAB21L1	1.77e-03	12	99	2	IPR024810
Domain	FERM_M	PTK2B TLN2 MYO15A	1.86e-03	46	99	3	PF00373
Domain	FERM_central	PTK2B TLN2 MYO15A	2.23e-03	49	99	3	IPR019748
Domain	FERM_domain	PTK2B TLN2 MYO15A	2.23e-03	49	99	3	IPR000299
Domain	FERM_1	PTK2B TLN2 MYO15A	2.36e-03	50	99	3	PS00660
Domain	FERM_2	PTK2B TLN2 MYO15A	2.36e-03	50	99	3	PS00661
Domain	FERM_3	PTK2B TLN2 MYO15A	2.36e-03	50	99	3	PS50057
Domain	Band_41_domain	PTK2B TLN2 MYO15A	2.36e-03	50	99	3	IPR019749
Domain	B41	PTK2B TLN2 MYO15A	2.36e-03	50	99	3	SM00295
Domain	Dynein_HC_stalk	DNHD1 DNAH6	2.43e-03	14	99	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH6	2.43e-03	14	99	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH6	2.43e-03	14	99	2	PF08393
Domain	MT	DNHD1 DNAH6	2.43e-03	14	99	2	PF12777
Domain	DAGKc	DGKD DGKH	2.43e-03	14	99	2	SM00046
Domain	CNH	CDC42BPB MAP4K5	2.43e-03	14	99	2	SM00036
Domain	DHC_fam	DNHD1 DNAH6	2.79e-03	15	99	2	IPR026983
Domain	Diacylglycerol_kinase_cat_dom	DGKD DGKH	2.79e-03	15	99	2	IPR001206
Domain	DAGK	DGKD DGKH	2.79e-03	15	99	2	PS50146
Domain	Dynein_heavy	DNHD1 DNAH6	2.79e-03	15	99	2	PF03028
Domain	DAGK_cat	DGKD DGKH	2.79e-03	15	99	2	PF00781
Domain	CNH	CDC42BPB MAP4K5	2.79e-03	15	99	2	PF00780
Domain	Dynein_heavy_dom	DNHD1 DNAH6	2.79e-03	15	99	2	IPR004273
Domain	CNH	CDC42BPB MAP4K5	2.79e-03	15	99	2	PS50219
Domain	CNH_dom	CDC42BPB MAP4K5	2.79e-03	15	99	2	IPR001180
Domain	PROTEIN_KINASE_ATP	EPHB3 PDGFRA MAP3K14 CDC42BPB ITK PTK2B MAP4K5 EIF2AK4	3.05e-03	459	99	8	PS00107
Domain	FN3	EPHB3 COL12A1 OBSL1 UMODL1 MYOM2	3.05e-03	185	99	5	SM00060
Domain	C1_1	DGKD DGKH CDC42BPB	3.44e-03	57	99	3	PF00130
Domain	ATPase_P-typ_cation-transptr_C	ATP2C1 ATP13A3	3.59e-03	17	99	2	IPR006068
Domain	Cation_ATPase_C	ATP2C1 ATP13A3	3.59e-03	17	99	2	PF00689
Domain	NAD/diacylglycerol_kinase	DGKD DGKH	3.59e-03	17	99	2	IPR016064
Domain	Cation_ATPase_N	ATP2C1 ATP13A3	4.03e-03	18	99	2	PF00690
Domain	FN3	EPHB3 COL12A1 OBSL1 UMODL1 MYOM2	4.16e-03	199	99	5	PS50853
Domain	Prot_kinase_dom	EPHB3 PDGFRA MAP3K14 CDC42BPB ITK PTK2B MAP4K5 EIF2AK4	4.46e-03	489	99	8	IPR000719
Domain	GTP_binding_domain	GTPBP4 MTG1	4.48e-03	19	99	2	IPR006073
Domain	ATPase_P-typ_cation-transptr_N	ATP2C1 ATP13A3	4.48e-03	19	99	2	IPR004014
Domain	PROTEIN_KINASE_DOM	EPHB3 PDGFRA MAP3K14 CDC42BPB ITK PTK2B MAP4K5 EIF2AK4	4.68e-03	493	99	8	PS50011
Domain	ZF_DAG_PE_1	DGKD DGKH CDC42BPB	4.76e-03	64	99	3	PS00479
Domain	ZF_DAG_PE_2	DGKD DGKH CDC42BPB	4.76e-03	64	99	3	PS50081
Domain	Pkinase_Tyr	EPHB3 PDGFRA ITK PTK2B	4.93e-03	129	99	4	PF07714
Domain	C1	DGKD DGKH CDC42BPB	4.97e-03	65	99	3	SM00109
Domain	FN3_dom	EPHB3 COL12A1 OBSL1 UMODL1 MYOM2	5.11e-03	209	99	5	IPR003961
Domain	PE/DAG-bd	DGKD DGKH CDC42BPB	5.19e-03	66	99	3	IPR002219
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	ZBTB38 COL12A1 HK2 REPS1 DGKD CCDC141 CDC42BPB ZNF462 PHF1 AKTIP MACF1 MYOM2	1.91e-08	497	99	12	23414517
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	OBSL1 CDC42BPB ZNF462 PHF3 MACF1 TLN2 AKAP11 SMG6	2.80e-07	225	99	8	12168954
Pubmed	Two murine and human homologs of mab-21, a cell fate determination gene involved in Caenorhabditis elegans neural development.	TRPC4 MAB21L2 MAB21L1	7.77e-07	7	99	3	10556287
Pubmed	Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung.	TCF7L2 SFRP4 TCF7L1	3.63e-06	11	99	3	11731265
Pubmed	Identification and characterization of two splice variants of human diacylglycerol kinase eta.	DGKD DGKH	8.02e-06	2	99	2	12810723
Pubmed	Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4α at the protein level.	TCF7L2 HNF4A	8.02e-06	2	99	2	24463962
Pubmed	A gene family of HMG-box transcription factors with homology to TCF-1.	TCF7L2 TCF7L1	8.02e-06	2	99	2	1741298
Pubmed	Depletion of Mab21l1 and Mab21l2 messages in mouse embryo arrests axial turning, and impairs notochord and neural tube differentiation.	MAB21L2 MAB21L1	8.02e-06	2	99	2	11857508
Pubmed	The Male Abnormal Gene Family 21 (Mab21) Members Regulate Eye Development.	MAB21L2 MAB21L1	8.02e-06	2	99	2	27558071
Pubmed	Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium.	TCF7L2 TCF7L1	8.02e-06	2	99	2	9916915
Pubmed	Genomic cloning and chromosomal localization of the mouse Mab21l2 locus.	MAB21L2 MAB21L1	8.02e-06	2	99	2	10516425
Pubmed	A PiggyBac-based recessive screening method to identify pluripotency regulators.	MSH6 TCF7L1	8.02e-06	2	99	2	21533166
Pubmed	Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.	DGKH NALCN TCF7L1	1.77e-05	18	99	3	19308021
Pubmed	Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling.	TCF7L2 TCF7L1	2.40e-05	3	99	2	17607356
Pubmed	A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells.	TCF7L2 TCF7L1	2.40e-05	3	99	2	25659031
Pubmed	In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators.	TCF7L2 TCF7L1	2.40e-05	3	99	2	24463605
Pubmed	UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors.	UBQLN4 ATM	2.40e-05	3	99	2	30612738
Pubmed	Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method.	DGKD DGKH	2.40e-05	3	99	2	23949095
Pubmed	TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.	TCF7L2 TCF7L1	2.40e-05	3	99	2	34525377
Pubmed	Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies.	TCF7L2 TCF7L1	2.40e-05	3	99	2	32403323
Pubmed	Genome-wide interrogation of longitudinal FEV1 in children with asthma.	ZBTB38 DGKH	2.40e-05	3	99	2	25221879
Pubmed	Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium.	TCF7L2 HNF4A	2.40e-05	3	99	2	19805521
Pubmed	LPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase, Pyk2 via the p38 MAPK/NF-kappaB-dependent pathway.	PTK2B CCL2	2.40e-05	3	99	2	18954908
Pubmed	TCF-3, 4 protein expression correlates with beta-catenin expression in MSS and MSI-H colorectal cancer from HNPCC patients but not in sporadic colorectal cancers.	TCF7L2 TCF7L1	2.40e-05	3	99	2	20532534
Pubmed	Structure of transcribing mammalian RNA polymerase II.	POLR2M SUPT5H	2.40e-05	3	99	2	26789250
Pubmed	The alymphoplasia (aly) mutation co-segregates with the intercellular adhesion molecule-2 (lcam-2) on mouse chromosome 11.	MAP3K14 CCL2	2.40e-05	3	99	2	7947467
Pubmed	Local retinoic acid signaling directs emergence of the extraocular muscle functional unit.	TCF7L2 COL12A1 RARG	2.46e-05	20	99	3	33201874
Pubmed	Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development.	TCF7L2 COL12A1 PDGFRA	2.46e-05	20	99	3	29084951
Pubmed	Identification of myosin II as a binding protein to the PH domain of protein kinase B.	DGKD PTK2B	4.79e-05	4	99	2	10082674
Pubmed	Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression.	CCL2 ATM	4.79e-05	4	99	2	28928376
Pubmed	A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.	TCF7L2 TCF7L1	4.79e-05	4	99	2	33587034
Pubmed	Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population.	TCF7L2 HNF4A	4.79e-05	4	99	2	20361036
Pubmed	Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3.	TCF7L2 HNF4A	4.79e-05	4	99	2	22951069
Pubmed	Mapping canonical Wnt signaling in the developing and adult retina.	TCF7L2 TCF7L1	4.79e-05	4	99	2	17065530
Pubmed	CCR2, MCP-1, SDF-1a & DC-SIGN gene polymorphisms in HIV-1 infected patients with & without tuberculosis.	CD209 CCL2	4.79e-05	4	99	2	19942750
Pubmed	The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.	REPS1 VPS45 CDC42BPB DOCK5 GLG1 EIF2AK4	5.26e-05	230	99	6	35449600
Pubmed	The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/β-catenin signaling.	TCF7L2 PDGFRA TCF7L1	5.55e-05	26	99	3	25810530
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	GTPBP4 TCF7L2 HK2 REPS1 VPS45 MAP3K14 RNF213 MAB21L2 MSH6 AKTIP EIF2B3 IPO13 ATP13A3 ATM	5.78e-05	1440	99	14	30833792
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZBTB38 REPS1 CRIM1 VPS45 UBQLN4 OBSL1 CDC42BPB CFAP298 SUPT5H HPF1 MACF1 TLN2 ATM	7.30e-05	1285	99	13	35914814
Pubmed	Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.	ITK PTK2B MAP4K5 EIF2AK4	7.50e-05	78	99	4	17192257
Pubmed	Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2.	TCF7L2 TCF7L1	7.98e-05	5	99	2	21285352
Pubmed	MAB21L1 modulates gene expression and DNA metabolic processes in the lens placode.	MAB21L2 MAB21L1	7.98e-05	5	99	2	34779479
Pubmed	Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein.	TERB1 SMC1B	7.98e-05	5	99	2	24885367
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TCF7L2 VPS45 RNF213 DGKH CDC42BPB C2CD2 ZNF462 DOCK5 ATP2C1 MACF1 EIF2AK4 SPATS2 POLK SMG6	8.25e-05	1489	99	14	28611215
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RNF213 DGKD FANCM CDC42BPB ZNF462 ATP2C1 TXNDC16 MACF1	8.54e-05	493	99	8	15368895
Pubmed	The protein tyrosine kinase family of the human genome.	EPHB3 PDGFRA ITK PTK2B	9.55e-05	83	99	4	11114734
Pubmed	Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse.	TCF7L2 TCF7L1	1.19e-04	6	99	2	9488439
Pubmed	Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.	TCF7L2 HNF4A	1.19e-04	6	99	2	17601994
Pubmed	An evolutionarily conserved nested gene pair - Mab21 and Lrba/Nbea in metazoan.	MAB21L2 MAB21L1	1.19e-04	6	99	2	19482073
Pubmed	Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain.	TCF7L2 TCF7L1	1.19e-04	6	99	2	23152144
Pubmed	Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures.	TCF7L2 TCF7L1	1.19e-04	6	99	2	11731231
Pubmed	NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.	HK2 MAP3K14	1.19e-04	6	99	2	33398181
Pubmed	Dazap2 modulates transcription driven by the Wnt effector TCF-4.	TCF7L2 TCF7L1	1.19e-04	6	99	2	19304756
Pubmed	Integrated analysis of Wnt signalling system component gene expression.	TCF7L2 SFRP4 TCF7L1	1.62e-04	37	99	3	35831952
Pubmed	Sumoylation is involved in beta-catenin-dependent activation of Tcf-4.	TCF7L2 HNF4A	1.67e-04	7	99	2	12727872
Pubmed	Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation.	MSH6 POLK	1.67e-04	7	99	2	24038355
Pubmed	MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway.	FANCM ATM	1.67e-04	7	99	2	26388201
Pubmed	Common variants in the GDF5-UQCC region are associated with variation in human height.	ZBTB38 PDGFRA	1.67e-04	7	99	2	18193045
Pubmed	Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome.	C2CD2 UMODL1	1.67e-04	7	99	2	11528125
Pubmed	β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells.	TCF7L2 TCF7L1	1.67e-04	7	99	2	32820720
Pubmed	RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis.	TCF7L2 TCF7L1	1.67e-04	7	99	2	18772112
Pubmed	Gene expression analysis of canonical Wnt pathway transcriptional regulators during early morphogenesis of the facial region in the mouse embryo.	TCF7L2 TCF7L1	1.67e-04	7	99	2	19303461
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ATP10B IPO13 MACF1 SMG6	2.04e-04	101	99	4	9872452
Pubmed	Connective tissue fibroblasts and Tcf4 regulate myogenesis.	TCF7L2 TCF7L1	2.22e-04	8	99	2	21177349
Pubmed	A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning.	TCF7L2 HNF4A	2.22e-04	8	99	2	14667415
Pubmed	TWIST1 Homodimers and Heterodimers Orchestrate Lineage-Specific Differentiation.	TCF7L2 TCF7L1	2.22e-04	8	99	2	32179550
Pubmed	Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling.	FANCM ATM	2.85e-04	9	99	2	25010009
Pubmed	Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis.	TCF7L2 TCF7L1	2.85e-04	9	99	2	17335794
Pubmed	TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4.	MED16 HNF4A	2.85e-04	9	99	2	12101254
Pubmed	Role and regulation of PDGFRα signaling in liver development and regeneration.	PDGFRA HNF4A	2.85e-04	9	99	2	23529017
Pubmed	HIV-1 impairs human retinal pigment epithelial barrier function: possible association with the pathogenesis of HIV-associated retinopathy.	CLDN3 CCL2	2.85e-04	9	99	2	24840331
Pubmed	Altered Maturation of Medullary TEC in EphB-Deficient Thymi Is Recovered by RANK Signaling Stimulation.	EPHB3 CLDN3	2.85e-04	9	99	2	29867988
Pubmed	A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.	MROH2A DGKH CCDC141 DTHD1 DNAH6	3.09e-04	205	99	5	12040188
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	DNHD1 RNF213 PHF3 TLN2 EIF2AK4	3.31e-04	208	99	5	33230847
Pubmed	Genetic variants near PDGFRA are associated with corneal curvature in Australians.	PDGFRA EIF2AK4	3.56e-04	10	99	2	22969067
Pubmed	The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons.	TRPC4 NALCN	3.56e-04	10	99	2	27177420
Pubmed	Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS.	TCF7L2 PDGFRA	3.56e-04	10	99	2	19515974
Pubmed	Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase.	ATM SMC1B	3.56e-04	10	99	2	19851446
Pubmed	The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.	TCF7L2 HNF4A	3.56e-04	10	99	2	18498634
Pubmed	A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal.	TCF7L2 TCF7L1	3.56e-04	10	99	2	22393260
Pubmed	The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis.	REPS1 PHF1 MYOM2	3.75e-04	49	99	3	32918875
Pubmed	A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication.	GTPBP4 ATP6V0B SFRP4 CLDN3 CD209	4.10e-04	218	99	5	19460752
Pubmed	Non-proteolytic ubiquitination of OTULIN regulates NF-κB signaling pathway.	HK2 ATP2C1	4.34e-04	11	99	2	31504727
Pubmed	Tcf7L2 is essential for neurogenesis in the developing mouse neocortex.	TCF7L2 TCF7L1	4.34e-04	11	99	2	29751817
Pubmed	HIV-1 gp120 Glycoprotein Interacting with Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN) Down-Regulates Tight Junction Proteins to Disrupt the Blood Retinal Barrier and Increase Its Permeability.	CD209 CCL2	4.34e-04	11	99	2	27605665
Pubmed	Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon.	TCF7L2 PDGFRA	4.34e-04	11	99	2	34222248
Pubmed	Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.	DGKD DGKH	4.34e-04	11	99	2	17021016
Pubmed	SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.	MSH6 ATM	4.34e-04	11	99	2	11877377
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	GTPBP4 ZNF462 MSH6 SUPT5H POLK	4.45e-04	222	99	5	37071664
Pubmed	Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1.	TCF7L2 TCF7L1	5.20e-04	12	99	2	10631168
Pubmed	Wnt signalling induces maturation of Paneth cells in intestinal crypts.	EPHB3 TCF7L2	5.20e-04	12	99	2	15778706
Pubmed	Redundant and additive functions of the four Lef/Tcf transcription factors in lung epithelial progenitors.	TCF7L2 TCF7L1	5.20e-04	12	99	2	32414917
Pubmed	BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.	MSH6 ATM	5.20e-04	12	99	2	10783165
Pubmed	A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.	ZBTB38 SFRP4	5.20e-04	12	99	2	19396169
Pubmed	HOXA5 protein expression and genetic fate mapping show lineage restriction in the developing musculoskeletal system.	TCF7L2 PDGFRA	5.20e-04	12	99	2	30604848
Pubmed	Rescuing lung development through embryonic inhibition of histone acetylation.	TCF7L2 PDGFRA	5.20e-04	12	99	2	38295182
Pubmed	All Tcf HMG box transcription factors interact with Groucho-related co-repressors.	TCF7L2 TCF7L1	5.20e-04	12	99	2	11266540
Pubmed	Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.	MTG1 POLR2M FANCM TRIM22 SPATS2	5.23e-04	230	99	5	29513927
Pubmed	Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia.	TCF7L2 TCF7L1	6.13e-04	13	99	2	19718027
Pubmed	Investigation of genes important in neurodevelopment disorders in adult human brain.	TCF7L2 TCF7L1	6.13e-04	13	99	2	26194112
Cytoband	2p16	MSH6 GPR75	3.00e-04	12	99	2	2p16
GeneFamily	EF-hand domain containing\|Diacylglycerol kinases	DGKD DGKH	5.80e-04	10	66	2	1178
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	PTK2B TLN2 MYO15A	8.06e-04	50	66	3	1293
Coexpression	GSE4590_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN	DGKD C2CD2 POLR3E PHF3 MAP4K5 EIF2AK4 ATP13A3	2.27e-06	157	99	7	M6871
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RNF213 TRIM22 ITK PHF3 PGAP1 MACF1 ATM DTHD1 SMG6	6.63e-10	199	99	9	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	RNF213 DGKH ITK MACF1 ATM SMG6	1.35e-06	156	99	6	1545169694f686d28648a68b552c2ae606599d66
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL12A1 CRIM1 PDGFRA NALCN MACF1 TLN2	2.64e-06	175	99	6	1799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	RNF213 DGKH ATP2C1 MACF1 ATP13A3 SMG6	3.99e-06	188	99	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMK+-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZBTB38 RNF213 ITK MACF1 ATM DTHD1	4.50e-06	192	99	6	ed1fb700d3e8f00495727d61e164fc0b70274fd0
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHB3 ZBTB38 ATP10B CLDN3 HNF4A PGAP1	4.92e-06	195	99	6	b67d4f34cae729c18275486d3b20c9dd7d5cbe79
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RNF213 DGKH ITK PGAP1 ATM DTHD1	5.22e-06	197	99	6	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZBTB38 RNF213 MACF1 MYOM2 ATM DTHD1	5.37e-06	198	99	6	a1b310274aa9b3d2aa1fe9488d67422bf4ac81d2
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RNF213 TRIM22 MACF1 MYOM2 ATM DTHD1	5.37e-06	198	99	6	0e918e9db9b884f5328d438e90efe065e27266ee
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZBTB38 RNF213 MACF1 MYOM2 ATM DTHD1	5.37e-06	198	99	6	76aff381403bc5a8a9cc73eb1e5dbdc0bac7de6c
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RNF213 TRIM22 MACF1 MYOM2 ATM DTHD1	5.37e-06	198	99	6	ce92d5fbc2eac27fb246b044fb1914ab92506275
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	RNF213 TRIM22 MACF1 MYOM2 ATM DTHD1	5.37e-06	198	99	6	fed823d6e684d113bcc9ff3cd1803bb001aa02fa
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RNF213 TRIM22 MACF1 MYOM2 ATM DTHD1	5.37e-06	198	99	6	1ef3a6bd681c223eed58300348adfef89df5563c
ToppCell	COVID-19_Mild-Lymphoid_T/NK-gd_T\|COVID-19_Mild / Disease group, lineage and cell class	ZBTB38 RNF213 MACF1 MYOM2 ATM DTHD1	5.37e-06	198	99	6	6aea5d00c417708f05b6d2dfe5a962d80864f8eb
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-gd_T\|COVID-19_Mild / Disease, condition lineage and cell class	ZBTB38 RNF213 MACF1 MYOM2 ATM DTHD1	5.69e-06	200	99	6	6560753d3df2f87860b52052d4881aa45410f666
ToppCell	mild-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZBTB38 RNF213 TRIM22 MACF1 ATM DTHD1	5.69e-06	200	99	6	d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-NK_activated\|COVID-19_Severe / Disease, condition lineage and cell class	RNF213 TRIM22 MACF1 MYOM2 ATM DTHD1	5.69e-06	200	99	6	6a77f9643646bafc1157bf1fc1e4c614860ee642
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-gd_T\|COVID-19_Severe / Disease, condition lineage and cell class	ZBTB38 RNF213 MACF1 MYOM2 ATM DTHD1	5.69e-06	200	99	6	f72bc3f6606ae77fe1b0a972e35b3ce0727804d9
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MTG1 HK2 MAP3K14 OBSL1 AIFM3	2.07e-05	149	99	5	defe2e4a2f3118f8b42e99a4f2bf03e54c1b698f
ToppCell	COVID-19_Moderate-multiplets\|World / disease group, cell group and cell class	RNF213 ITK PGAP1 MACF1 MYOM2	2.58e-05	156	99	5	afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA3A COL12A1 MROH2A ADCY2 DTHD1	2.92e-05	160	99	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA3A COL12A1 MROH2A ADCY2 DTHD1	2.92e-05	160	99	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	VWA3A ATP10B CLDN3 ADCY2 DNAH6	3.38e-05	165	99	5	0c714e852f912b5749de4cb0895406673979b2e6
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	VWA3A ATP10B CLDN3 ADCY2 DNAH6	3.38e-05	165	99	5	82530f96aaefe28a13bad0474bbad043f127a86c
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VWA3A PGAP1 MDH1B DTHD1 DNAH6	3.79e-05	169	99	5	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	RNF213 ITK MACF1 ATM DTHD1	4.01e-05	171	99	5	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	normal_Lung-T/NK_cells-CD8+/CD4+_Mixed_Th\|T/NK_cells / Location, Cell class and cell subclass	REPS1 FANCM ZNF783 PGAP1 CCL2	4.12e-05	172	99	5	0657c736f3c52d25cf7f652eac005ddcde9232ef
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-NK_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNF213 FANCM GPR75 TXNDC16 DTHD1	4.12e-05	172	99	5	f3c16a62eba1ed190318beee131c71c5150b266a
ToppCell	367C-Myeloid-Monocyte-CD16+_Monocyte\|Monocyte / Donor, Lineage, Cell class and subclass (all cells)	HK2 REPS1 GSTCD CCL2 TTC33	4.12e-05	172	99	5	fb8ab2576b5c38db63573a3bf46b8d9d634c4999
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SFRP4 PDGFRA MAB21L2 CCL2 TCF7L1	4.35e-05	174	99	5	1d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell	RSV-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	LRRIQ3 RNF213 TRIM22 DOCK5 TLN2	4.47e-05	175	99	5	ff3a27f512a3a710ebc863b7b75cce8167d5440b
ToppCell	RSV-Healthy-1\|RSV / Virus stimulation, Condition and Cluster	LRRIQ3 RNF213 TRIM22 DOCK5 TLN2	4.47e-05	175	99	5	ca52b99b03535a5b3a2751d6981708dc5b255b91
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_AB\|TCGA-Thymus / Sample_Type by Project: Shred V9	EPHB3 SFRP4 ADCY2 NALCN TCF7L1	4.47e-05	175	99	5	50f9b994bdd389158f92f891944ea81b2fb15eef
ToppCell	10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma-muscle_stem_cell\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	COL12A1 RARG TRPC4 MAB21L2 TCF7L1	4.85e-05	178	99	5	8f31b3fac51591f7f2bcb898c07708b3e9f93a16
ToppCell	T_cells-ISG-high_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	RNF213 ATP10B TRIM22 TDRD7 PGAP1	4.98e-05	179	99	5	af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCell	C_00\|World / shred on cell type and cluster	EPHB3 ZBTB38 RPS2 ATP10B PGAP1	4.98e-05	179	99	5	da2dadc3266ffebd4a34ac61bfa05fddcadcde4c
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	RNF213 DGKH ITK MACF1 ATM	5.25e-05	181	99	5	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	COVID-19_Mild-gd_T\|COVID-19_Mild / Disease condition and Cell class	TCF7L2 RNF213 DGKD MACF1 MYOM2	5.53e-05	183	99	5	f593a89b0aa8fffdfa403769916facfd30358521
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VWA3A CRIM1 DOCK5 NALCN TCF7L1	5.53e-05	183	99	5	848fc6dd129150897ee339343e83c645b6e779eb
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 MROH2A TLN2 MYOM2 MYO15A	5.68e-05	184	99	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 MROH2A TLN2 MYOM2 MYO15A	5.68e-05	184	99	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 MROH2A TLN2 MYOM2 MYO15A	5.68e-05	184	99	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB3 AIFM3 CCL2 SPATS2 DTHD1	5.82e-05	185	99	5	05bc89a566b0db90ae06506e067190a4739a0974
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	DGKD HNF4A TLN2 SPATS2 SMG6	5.98e-05	186	99	5	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	DGKD HNF4A TLN2 SPATS2 SMG6	5.98e-05	186	99	5	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RNF213 DGKD ITK MACF1 ATM	6.61e-05	190	99	5	d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TCF7L2 UBQLN4 MSH6 PHF3 CCL2	6.61e-05	190	99	5	651a1d3ae286e40f9d9f60e438211c6148d24143
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_2-SCMF\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL12A1 PDGFRA NALCN TLN2 PLPP4	6.94e-05	192	99	5	67e845e513e76e820f55e2f0d15eb16f2944d05c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	MAP3K14 DGKD DGKH MACF1 ATP13A3	6.94e-05	192	99	5	8b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMK+\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZBTB38 RNF213 ITK MACF1 ATM	6.94e-05	192	99	5	6779b0294bb058e748e22b795b6a381c4add37e9
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo-stroma-early_osteoblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	COL12A1 SFRP4 PCDHGB7 PDGFRA MAB21L2	7.11e-05	193	99	5	5e46a9f65e85aca78f825fdef88a95b97eec8743
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RNF213 DGKH ITK MACF1 ATM	7.11e-05	193	99	5	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZBTB38 RNF213 ITK MACF1 ATM	7.11e-05	193	99	5	fce4f805e53669acb4c188f87ac7d84408c0c218
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZBTB38 RNF213 ITK MACF1 ATM	7.11e-05	193	99	5	6e1498153a7766c03fddbda1701dbf1596d21736
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_progenitor_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB3 TCF7L2 ATP10B CLDN3 CCDC141	7.29e-05	194	99	5	0ef63abcfd057079a9a6f8b27404ff521d44845d
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-epithelial_progenitor_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHB3 ATP10B CLDN3 HNF4A PGAP1	7.29e-05	194	99	5	46e522ca59db545d1eb0c27cd4361f19d4f8f762
ToppCell	facs-Thymus-nan-3m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DGKD ITK MSH6 PHF3 ATP13A3	7.29e-05	194	99	5	66c056232ac216780acf4cc8ea325bd8ed1909c9
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VWA3A CLDN3 MDH1B DTHD1 DNAH6	7.47e-05	195	99	5	43f0c257e4bb5c627afbdfc695c1199c672842d3
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VWA3A CLDN3 MDH1B DTHD1 DNAH6	7.47e-05	195	99	5	cd6cfe3ef150a4a4575e04fc8a8213cdceefa1c4
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VWA3A CLDN3 MDH1B DTHD1 DNAH6	7.47e-05	195	99	5	e22ca35bea06aa95ff2cc771632969f5e7229ffc
ToppCell	COVID-19_Severe-Lymphoid_T/NK-gd_T\|COVID-19_Severe / Disease group, lineage and cell class	RNF213 MACF1 MYOM2 ATM DTHD1	7.47e-05	195	99	5	9990440bda7fac5d00ef80444fab07459be625e1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	RNF213 MACF1 MYOM2 ATM DTHD1	7.65e-05	196	99	5	418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCell	Control-Myeloid-Macrophage\|Control / Disease state, Lineage and Cell class	SEMA6B ATP6V0B PTK2B CCL2 ATP13A3	7.65e-05	196	99	5	e2c2a30fa3ee3034fbde5335be169e880dde622d
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RNF213 MACF1 MYOM2 ATM DTHD1	7.65e-05	196	99	5	581fc8c8d42005aacd7b401a2c9d1fc331fb4af7
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHB3 ATP10B CLDN3 HNF4A PGAP1	7.65e-05	196	99	5	97324c9e93f833e1f218e81fb53066d44c6892df
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RNF213 MACF1 MYOM2 ATM DTHD1	7.65e-05	196	99	5	6beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RNF213 MACF1 MYOM2 ATM DTHD1	7.65e-05	196	99	5	c35f2349dfe35baa845f790b9f31673dceac54c0
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RNF213 DGKH ITK MACF1 ATM	7.84e-05	197	99	5	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-epithelial_progenitor_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHB3 ATP10B CLDN3 HNF4A PGAP1	7.84e-05	197	99	5	c0250509836f1be04f5e54386191d7bb1e1da652
ToppCell	mild-Treg\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZBTB38 DGKH CCDC141 TRIM22 ITK	7.84e-05	197	99	5	39800e6e83f2d333b753d121c7aeb2912b91faa2
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 SFRP4 PDGFRA NALCN CCL2	7.84e-05	197	99	5	4cf4e9553397cd8dee883dbec24f41bec41aff99
ToppCell	ASK452-Epithelial-Transformed_epithelium\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	GTPBP4 RPS2 DOCK5 CCL2 SPATS2	7.84e-05	197	99	5	e92757e988888347c74286cc42c262b03159b0b9
ToppCell	COVID_vent-Lymphocytic-T_cell-CD8+_Memory_T_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	ZBTB38 RNF213 MACF1 ATM DTHD1	7.84e-05	197	99	5	d4dfb3b561d0783cdbee4e8d27009ad81df695cb
ToppCell	systemic_lupus_erythematosus-flare\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RNF213 ITK PHF3 MACF1 ATM	8.03e-05	198	99	5	4c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell	healthy_donor-Lymphocytic-ILC-NK_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	RNF213 MACF1 MYOM2 ATM DTHD1	8.03e-05	198	99	5	d7053a898e04478c577381085f615edaad3cdc5b
ToppCell	COVID-19_Moderate-CD8+_Tem\|World / disease group, cell group and cell class	ZBTB38 RNF213 ITK MYOM2 DTHD1	8.03e-05	198	99	5	1d12be256af028c88e31fb535068bae16b7bd48e
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_cytokine_secreting_effector_T_cell\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ZBTB38 MACF1 MYOM2 ATM DTHD1	8.03e-05	198	99	5	34c564ece9a2b94dcf646e3c95b5be9c5ecfaafe
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	RNF213 MACF1 MYOM2 ATM DTHD1	8.03e-05	198	99	5	a781fd35a7cda8b7760c2e3ddccaac7aac26c979
ToppCell	healthy_donor-Lymphocytic-ILC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	RNF213 MACF1 MYOM2 ATM DTHD1	8.03e-05	198	99	5	aa33be29e26f1b8facfc894413099083ae3bbb1b
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-epithelial_progenitor_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHB3 ATP10B CLDN3 HNF4A PGAP1	8.03e-05	198	99	5	e8bfae3888b2406b5629b576cb02913b3297337e
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RNF213 MACF1 MYOM2 ATM DTHD1	8.03e-05	198	99	5	df399674345c45738d765a8354ea8d1484572c34
ToppCell	COVID-19_Severe-Lymphoid_T/NK-NK_activated\|COVID-19_Severe / Disease group, lineage and cell class	RNF213 TRIM22 MYOM2 ATM DTHD1	8.22e-05	199	99	5	edf5f80b4c299e6bf462675f2cd3329d86c923d8
ToppCell	COVID_non-vent-Lymphocytic-ILC\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	RNF213 MACF1 MYOM2 ATM DTHD1	8.22e-05	199	99	5	df4f7d5be099e3e6054f3b812ccf70251664e4c0
ToppCell	COVID_non-vent-Lymphocytic-ILC-NK_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	RNF213 MACF1 MYOM2 ATM DTHD1	8.22e-05	199	99	5	ed35d747f11f6ea6a5cb7061057f0a98d9e0db99
ToppCell	healthy_donor-Lymphocytic\|healthy_donor / Disease condition, Lineage, Cell class and subclass	ZBTB38 RNF213 ITK MACF1 ATM	8.22e-05	199	99	5	2841e16d54acd344ba454f024e285c28abc37319
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VWA3A CLDN3 MDH1B DTHD1 DNAH6	8.41e-05	200	99	5	cc906ff02fd335ff633b3b97afceb670494f910a
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	COL12A1 RNF213 DGKH TRIM22 MACF1	8.41e-05	200	99	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VWA3A CLDN3 MDH1B DTHD1 DNAH6	8.41e-05	200	99	5	79e59ab31d3d3385b1b072dc75508af9546c2e1b
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	VWA3A LRRIQ3 MDH1B DTHD1 DNAH6	8.41e-05	200	99	5	af6a551f83808c1c839df7ba7b1702ca28ea6e1b
ToppCell	Control-Control-Lymphocyte-T/NK-NK\|Control / Disease, condition lineage and cell class	RNF213 MACF1 MYOM2 ATM DTHD1	8.41e-05	200	99	5	c64c27dbf4df42ca2ad2bd94b50fab87b4050ef3
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RNF213 TRIM22 PHF3 MACF1 ATM	8.41e-05	200	99	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	mild-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZBTB38 RNF213 MACF1 ATM DTHD1	8.41e-05	200	99	5	109f673a4967ffa52270a0b4f818b3461288db44
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	RNF213 DGKH TRIM22 ITK PGAP1	8.41e-05	200	99	5	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	VWA3A LRRIQ3 MDH1B DTHD1 DNAH6	8.41e-05	200	99	5	73ac1cf40ddd764be1100cbfaaa29563665457d8
ToppCell	mild-NK\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RNF213 TRIM22 MACF1 ATM DTHD1	8.41e-05	200	99	5	a11fb1d7e124c352eb73fea0e0ec0fed577c97f7
ToppCell	Parenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_myofibroblast\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	COL12A1 SFRP4 PDGFRA NALCN TLN2	8.41e-05	200	99	5	251fd2923f108cd2086961d897244b392c32ad54
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	RNF213 TRIM22 MACF1 MYOM2 DTHD1	8.41e-05	200	99	5	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VWA3A CLDN3 MDH1B DTHD1 DNAH6	8.41e-05	200	99	5	873def69bf55ccbfc944bc10c5afc06be019c312
ToppCell	mild-CD8+_T_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CCDC141 TRIM22 ITK PHF3 ATM	8.41e-05	200	99	5	c825320599a61a4c629d736f5c0fd6f1f405540a
ToppCell	E18.5-samps-Epithelial-Alveolar_epithelial-Uncommitted_AE_Progenitor\|E18.5-samps / Age Group, Lineage, Cell class and subclass	CLDN3 PHF1 NUTM1 TERB1	1.64e-04	123	99	4	5f002f5180fe47fe57ab888b5f0319df99ab2c59
Drug	Rilmenidine hemifumarate [54187-04-1]; Down 200; 8.4uM; MCF7; HT_HG-U133A	EPHB3 MED16 BRF1 GLG1 PGAP1 MACF1 TLN2 TTC33	2.47e-06	198	99	8	5532_DN
Drug	Artemisinin [63968-64-9]; Down 200; 14.2uM; PC3; HT_HG-U133A	GTPBP4 MTG1 TCF7L2 CLDN3 CDC42BPB ATP2C1 BRF1 TTC33	2.57e-06	199	99	8	7247_DN
Drug	Trihexyphenidyl-D,L Hydrochloride [58947-95-8]; Down 200; 11.8uM; HL60; HT_HG-U133A	MTG1 MED16 MAP3K14 ZNF783 PTK2B PHF3 GLG1	2.40e-05	196	99	7	2158_DN
Drug	Cetirizine dihydrochloride [83881-52-1]; Down 200; 8.6uM; MCF7; HT_HG-U133A	TCF7L2 RARG MED16 RPS2 TDRD7 MSH6 BRF1	2.40e-05	196	99	7	4815_DN
Drug	Glutethimide, para-amino [125-84-8]; Down 200; 17.2uM; MCF7; HT_HG-U133A	EPHB3 TCF7L2 MED16 DGKD BRF1 ATP13A3 ATM	2.48e-05	197	99	7	7463_DN
Drug	Dinoprost trometamol [38362-01-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A	EPHB3 GTPBP4 TCF7L2 RARG MED16 DGKD ZNF783	2.48e-05	197	99	7	3308_DN
Drug	Fipexide hydrochloride [34161-23-4]; Down 200; 9.4uM; HL60; HG-U133A	MTG1 TCF7L2 RPS2 VPS45 TRIM22 MACF1 ATM	2.56e-05	198	99	7	1560_DN
Drug	cis-4,7,10,13,16,19-Docosahexaenoic acid ethyl ester; Down 200; 100uM; MCF7; HT_HG-U133A_EA	TCF7L2 CRIM1 PHF1 ATP2C1 PHF3 PGAP1 TLN2	2.56e-05	198	99	7	881_DN
Drug	Midodrine hydrochloride [3092-17-9]; Up 200; 13.8uM; MCF7; HT_HG-U133A	EPHB3 SFRP4 MED16 RPS2 BRF1 PGAP1 TLN2	2.65e-05	199	99	7	6804_UP
Drug	Hyoscyamine (L) [101-31-5]; Up 200; 13.8uM; HL60; HG-U133A	EPHB3 RARG ATP10B DOCK5 CCL2 ATP13A3 ATM	2.65e-05	199	99	7	1424_UP
Drug	lanthanum	TRPC4 ADCY2 PTK2B ATP2C1 MAP4K5 GSTCD	2.89e-05	136	99	6	CID000023926
Disease	myeloid white cell count	TCF7L2 MAP3K14 UBQLN4 DGKH HNF4A PTK2B SUPT5H GLG1 MAP4K5 TLN2 AKAP11 DTHD1 TCF7L1 SMG6	2.64e-06	937	98	14	EFO_0007988
Disease	Tuberculosis, Pulmonary	CD209 CCL2	3.27e-05	3	98	2	C0041327
Disease	bone density	TCF7L2 SFRP4 DGKD MAP4K5 SPATS2 MYO15A TCF7L1 SMG6	4.67e-05	388	98	8	EFO_0003923
Disease	total blood protein measurement	TCF7L2 ZBTB38 CRIM1 DGKD MAP4K5 MACF1 TCF7L1 SMG6	1.29e-04	449	98	8	EFO_0004536
Disease	diabetic angiopathy (implicated_via_orthology)	PTK2B CCL2	1.62e-04	6	98	2	DOID:11713 (implicated_via_orthology)
Disease	nephrolithiasis	DGKD DGKH MAP4K5	1.80e-04	33	98	3	EFO_0004253
Disease	neutrophil percentage of leukocytes	ZBTB38 MFSD2B DGKH HNF4A GLG1 MAP4K5 AKAP11 DTHD1 TCF7L1	2.00e-04	610	98	9	EFO_0007990
Disease	Thyroid Gland Follicular Adenoma	MSH6 CCL2 TCF7L1	2.15e-04	35	98	3	C0151468
Disease	pulmonary function measurement, forced expiratory volume	ZBTB38 DGKH GSTCD	2.54e-04	37	98	3	EFO_0003892, EFO_0004314
Disease	Thyroid Neoplasm	MSH6 CCL2 TCF7L1	2.54e-04	37	98	3	C0040136
Disease	hemoglobin A1 measurement	TCF7L2 ZBTB38 MFSD2B DGKD MAP4K5 MACF1 SMG6 ILKAP	3.46e-04	520	98	8	EFO_0007629
Disease	level of Sterol ester (27:1/16:1) in blood serum	HNF4A MAP4K5	3.87e-04	9	98	2	OBA_2045190
Disease	Thyroid carcinoma	MSH6 CCL2 TCF7L1	4.26e-04	44	98	3	C0549473
Disease	MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding)	CD209 CCL2	4.83e-04	10	98	2	C1834752
Disease	Mycobacterium tuberculosis, susceptibility to	CD209 CCL2	4.83e-04	10	98	2	cv:C1834752
Disease	MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO	CD209 CCL2	4.83e-04	10	98	2	607948
Disease	level of Sterol ester (27:1/18:3) in blood serum	HNF4A MAP4K5	4.83e-04	10	98	2	OBA_2045193
Disease	maturity-onset diabetes of the young (implicated_via_orthology)	HK2 HNF4A	4.83e-04	10	98	2	DOID:0050524 (implicated_via_orthology)
Disease	cerebral cavernous malformation (implicated_via_orthology)	RNF213 CDC42BPB	5.89e-04	11	98	2	DOID:0060669 (implicated_via_orthology)
Disease	total cholesterol measurement, diastolic blood pressure, triglyceride measurement, systolic blood pressure, hematocrit, ventricular rate measurement, glucose measurement, body mass index, high density lipoprotein cholesterol measurement	TCF7L2 MAP4K5 POLK	6.59e-04	51	98	3	EFO_0004340, EFO_0004348, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928
Disease	red blood cell density measurement	TCF7L2 MFSD2B HNF4A ZNF462 BRF1 MAP4K5 EIF2AK4 MYO15A TTC33 SMG6	6.95e-04	880	98	10	EFO_0007978
Disease	Influenza	TRIM22 TDRD7 CCL2	6.98e-04	52	98	3	C0021400
Disease	Spina Bifida	PDGFRA CCL2	7.05e-04	12	98	2	C0080178
Disease	Status Dysraphicus	PDGFRA CCL2	7.05e-04	12	98	2	C0038219
Disease	microphthalmia (implicated_via_orthology)	CRIM1 IPO13	7.05e-04	12	98	2	DOID:10629 (implicated_via_orthology)
Disease	Rachischisis	PDGFRA CCL2	7.05e-04	12	98	2	C0266508
Disease	Cardiotoxicity	RARG CCL2	8.32e-04	13	98	2	C0876994
Disease	vascular endothelial growth factor measurement	ZBTB38 DGKH ZNF462	8.67e-04	56	98	3	EFO_0004762
Disease	platelet component distribution width	CLDN3 DOCK5 BRF1 EIF2B3 MACF1 EIF2AK4 ATP13A3 POLK TCF7L1	9.29e-04	755	98	9	EFO_0007984
Disease	2-oxo-hept-3-ene-1,7-dioate hydratase activity	EIF2AK4 ATP13A3	9.68e-04	14	98	2	C1150929
Disease	cholesterol to total lipids in IDL percentage	MAP4K5 MACF1 POLK	1.06e-03	60	98	3	EFO_0022233
Disease	urolithiasis	DGKD DGKH MAP4K5	1.22e-03	63	98	3	MONDO_0024647
Disease	phospholipid measurement	HNF4A MAP4K5 POLK ILKAP	1.24e-03	140	98	4	EFO_0004639
Disease	migraine disorder	RNF213 LYZL1 ZNF462 PTK2B MACF1 SMG6	1.24e-03	357	98	6	MONDO_0005277
Disease	–	CD209 CCL2	1.27e-03	16	98	2	609423
Disease	Susceptibility to HIV infection	CD209 CCL2	1.27e-03	16	98	2	cv:C1836230
Disease	Intrahepatic cholestasis of pregnancy	HNF4A MAP4K5	1.27e-03	16	98	2	EFO_0009048
Disease	leptin measurement, type 2 diabetes mellitus	TCF7L2 MAP4K5	1.27e-03	16	98	2	EFO_0005000, MONDO_0005148
Disease	breast carcinoma (is_marker_for)	PDGFRA MSH6 ATM	1.40e-03	66	98	3	DOID:3459 (is_marker_for)
Disease	Familial primary pulmonary hypertension	EIF2AK4 ATP13A3	1.44e-03	17	98	2	C0340543
Disease	diabetes mellitus	TCF7L2 EML2 HNF4A	1.52e-03	68	98	3	EFO_0000400
Disease	total cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer	TCF7L2 MAP4K5 POLK	1.59e-03	69	98	3	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Disease	fasting blood insulin measurement	TCF7L2 NALCN MAP4K5	1.59e-03	69	98	3	EFO_0004466
Disease	serum hepcidin measurement	DGKH AKAP11	1.61e-03	18	98	2	EFO_0004504
Disease	migraine disorder, systolic blood pressure	RNF213 SMG6	1.61e-03	18	98	2	EFO_0006335, MONDO_0005277
Disease	Cholecystitis	HNF4A MAP4K5	1.80e-03	19	98	2	HP_0001082
Disease	free cholesterol to total lipids in large LDL percentage	MAP4K5 MACF1 POLK	1.94e-03	74	98	3	EFO_0022280
Disease	exercise test	RARG POLR2M	2.00e-03	20	98	2	EFO_0004328
Disease	end stage renal disease (implicated_via_orthology)	GTPBP4 CCL2	2.00e-03	20	98	2	DOID:783 (implicated_via_orthology)
Disease	neutrophil count	VPS45 UBQLN4 DGKH HNF4A SUPT5H GLG1 MAP4K5 TLN2 AKAP11 DTHD1 TCF7L1 SMG6	2.09e-03	1382	98	12	EFO_0004833
Disease	complex trait	ZBTB38 HNF4A CCDC141 MAP4K5 MACF1	2.13e-03	271	98	5	EFO_0010578
Disease	triacylglycerol 54:6 measurement	MAP4K5 PLPP4	2.42e-03	22	98	2	EFO_0010424
Disease	post-traumatic stress disorder symptom measurement	TCF7L2 POLR2M PHF1	2.60e-03	82	98	3	EFO_0008535
Disease	phosphatidylcholine measurement	HNF4A PHF1 MAP4K5 MACF1 PLPP4	2.61e-03	284	98	5	EFO_0010226
Disease	gestational diabetes	TCF7L2 MAP4K5	2.64e-03	23	98	2	EFO_0004593
Disease	BMI-adjusted fasting blood glucose measurement	TCF7L2 MAP4K5	2.64e-03	23	98	2	EFO_0008036
Disease	Pseudoaphakia	TDRD7 ATM	2.87e-03	24	98	2	C0524524
Disease	Lens Opacities	TDRD7 ATM	2.87e-03	24	98	2	C1510497
Disease	lipoprotein measurement, phospholipid measurement	HNF4A MAP4K5 POLK	2.88e-03	85	98	3	EFO_0004639, EFO_0004732
Disease	unipolar depression, schizophrenia	TCF7L2 VPS45	3.12e-03	25	98	2	EFO_0003761, MONDO_0005090
Disease	fasting blood glucose measurement, HOMA-B, fasting blood insulin measurement	TCF7L2 MAP4K5	3.12e-03	25	98	2	EFO_0004465, EFO_0004466, EFO_0004469

Protein segments in the cluster

Peptide	Gene	Start	Entry
TGAVRVLCEIEKVVV	UMODL1	986	Q5DID0
TSDKVIAADCKRVTV	SMG6	1116	Q86US8
VTEKLTRREVEAKFC	EIF2AK4	1231	Q9P2K8
VLKSSKVVRADVCVV	AIFM3	411	Q96NN9
KATCVRAAIKDCEVV	ATP13A3	56	Q9H7F0
VVANKCDVKRIAELS	GTPBP4	286	Q9BZE4
SKVVDSVKVCTARLF	AKTIP	211	Q9H8T0
CVIKERTVAQIKATV	BAP18	66	Q8IXM2
EVITEAEKIAKVRNC	AKAP11	1266	Q9UKA4
ITACKEVGAQLVVIK	CD209	281	Q9NNX6
KIRALDTCKAVEAAE	DNHD1	3781	Q96M86
SSVCIVAEIIKKVER	ATP2C1	886	P98194
TLCIAKKVVSEEDFR	ATP10B	836	O94823
SELATKCIIKIVEFA	RARG	231	P13631
ADLKRICKTIVEAAS	HPF1	246	Q9NWY4
SLSTRCKVIVEVVDE	PCDHGB7	326	Q9Y5F8
VRVVSGAEAELKCVV	OBSL1	21	O75147
AKVEETIAVRCLAKN	PDGFRA	491	P16234
LTDAIICARKIVKET	LYZL1	106	Q6UWQ5
DADLKRICKTIVEAA	nan	246	A8MVJ9
ERHLKIKTCTVALDV	MYO15A	3221	Q9UKN7
FERICVIVEKDREKT	FANCM	1891	Q8IYD8
SIIVKEVCTVVARRA	HK2	816	P52789
IRAKKIASIADVCES	HNF4A	176	P41235
ACDNVERVLKSVAVK	MTG1	261	Q9BT17
VREFAKEIDVSCVKI	EPHB3	621	P54753
VCKQAEEVVVTLKVL	MFSD2B	446	A6NFX1
KNKVRTRTVAECVAF	MIER3	306	Q7Z3K6
EVTRDVIVRAADCKK	CDC42BPB	1266	Q9Y5S2
AVVISSAKTLCETVK	DGKH	506	Q86XP1
VVKELAETIKCRTLF	MSH6	1231	P52701
VRVKDGKVCVSAERE	ODF1	141	Q14990
ICVVKIIRRTDKTEI	PLPP4	66	Q5VZY2
DSKAVVTCVIIVLSV	GPR75	316	O95800
EKREVIVEESIRTCK	MACF1	2981	Q9UPN3
VSVVSEKCRIDTEIL	MED16	246	Q9Y2X0
ELCSQKVFVSKVEAV	NUTM1	416	Q86Y26
VIVVTTRDVQKALCA	EIF2B3	51	Q9NR50
KKKVDVVICLSTTVR	GLG1	771	Q92896
TLVEDCVKVRSAAVT	ATM	1721	Q13315
CEAIKKVRDATGVDI	ADCY2	366	Q08462
AIISKKQVEAGVCVT	CFAP298	121	P57076
EVCIKVTIINFTVTK	DNAH6	3181	Q9C0G6
VSSVLRSAEEKVVVC	C2CD2	116	Q9Y426
VQAGDSKIVIAVIKC	CCDC141	21	Q6ZP82
ETVKVSIAIEEVTRC	DOCK5	511	Q9H7D0
KVQVECSRGVDIKAD	COL12A1	426	Q99715
KEAVIFKTIVAKEIC	CCL2	61	P13500
EGKEKVLVTTNVCAR	DDX19B	381	Q9UMR2
ISVEKTVKRCLLDTF	ILKAP	181	Q9H0C8
LVSVDCKKGTRVQVD	CRIM1	986	Q9NZV1
VITIECSDKEKRVPF	DTHD1	221	Q6ZMT9
VLRSVSICTKVEEAF	MDH1B	191	Q5I0G3
AIAKTIREVCKVVSD	MAB21L2	26	Q9Y586
IREVCKVVSDVLKEV	MAB21L2	31	Q9Y586
ISSAKVLCETVKDFV	DGKD	501	Q16760
VLCETVKDFVARVGK	DGKD	506	Q16760
TKVVDVKCSNEAVLV	EML2	196	O95834
FKLVKCTVQTEIREI	PTK2B	56	Q14289
AKLKAAIAECEEVRR	POLR2M	56	P0CAP2
VVRKEVATVTKLCAE	POLR3E	366	Q9NVU0
FKICLVVTKEVSRDS	GSTCD	46	Q8NEC7
VVEAVCAIFEKSVKT	IPO13	701	O94829
RDTVLVCLDKFVKIV	MAP4K5	736	Q9Y4K4
CAVKKVRLEVFRAEE	MAP3K14	426	Q99558
ELSRIKCVEIVKSDI	ITK	56	Q08881
VEKIFCASSRIAKVV	MROH2A	1056	A6NES4
IKKVDSAREVCLVQF	PHF1	51	O43189
CDIESTKKVVVNGRV	REPS1	21	Q96D71
AIAKTIREVCKVVSD	MAB21L1	26	Q13394
IREVCKVVSDVLKEV	MAB21L1	31	Q13394
KINVVSKCSAVKEEI	PGAP1	506	Q75T13
TVKCKIGEERATAIS	SUPT5H	181	O00267
CSIKVTKVDETRGIA	TDRD7	801	Q8NHU6
KELSFARIKAVECVE	PHLDA3	51	Q9Y5J5
CVQDDTAKAKITIVA	CLDN3	106	O15551
VAKTFEKCIIEAVSS	RNF213	991	Q63HN8
EKVVVSRVARVCKND	SEMA6B	256	Q9H3T3
VARFTCDVETLKKSI	SPATS2	351	Q86XZ4
GISVAKVNCVKEEIS	TXNDC16	76	Q9P2K2
RAKVVAECTLKESAA	TCF7L1	361	Q9HCS4
VVASEKVAKDCIRFL	SMC1B	546	Q8NDV3
CNEVTTVVDVKEIFK	SFRP4	211	Q6FHJ7
IKTKNLVSIIFCEAV	ATP6V0B	86	Q99437
AKVVAECTLKESAAI	TCF7L2	366	Q9NQB0
KIKEISSVDCIALVD	POLK	691	Q9UBT6
IKASGTKEICVVRFT	PHF3	1261	Q92576
SEAAKRLAECVKQVI	VPS45	181	Q9NRW7
VKEVISVVKVCESTL	BRF1	246	Q92994
DVCKIDSSGIVVKRF	ZNF502	31	Q8TBZ5
LIECARAVTEKVSLV	TLN2	1951	Q9Y4G6
LKNETVAICVVTADK	ZNF462	2481	Q96JM2
ILCDVTIIVEDTKFK	ZBTB38	31	Q8NAP3
VKCSKEVATAIRGAI	RPS2	141	P15880
IVICDRASVKEFKEE	UBQLN4	26	Q9NRR5
QACITAKIKESVIIS	TRIM22	36	Q8IYM9
SAKLAVVVTKTVDAC	TERB1	266	Q8NA31
RVCPFKSEKVVVEDT	TRPC4	926	Q9UBN4
TVCEKRVVVLLDISA	VWA3A	506	A6NCI4
VVAAIQALEKKVDSC	ZNF783	46	Q6ZMS7
IVAVCAAIAEKEKTV	TTC33	211	Q6PID6
ACERLQDAKTKVAIV	LRRIQ3	596	A6PVS8
EKETAVTKILRACTR	NALCN	721	Q8IZF0
VRLVCKVANTKKETV	MYOM2	1146	P54296