Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH3 DNAH1 DNAH5 DNAH9

5.35e-06181334GO:0008569
GeneOntologyMolecularFunctionstructural molecule activity

MYH11 KRT31 KRT33A KRT33B KRT34 CAMK2B PPFIA2 LAMA3 APOE ACTR2 MMRN1 VCAN KRT222 KRT20 MACF1 PLEC MRPL9 HOMER1

2.61e-0589113318GO:0005198
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH3 DNAH1 DNAH5 DNAH9

3.40e-05281334GO:0051959
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH3 DNAH1 DNAH5 DNAH9

1.05e-04371334GO:0045505
GeneOntologyMolecularFunctioncytoskeleton-nuclear membrane anchor activity

SYNE1 SYNE2

4.35e-0451332GO:0140444
GeneOntologyBiologicalProcessintermediate filament cytoskeleton organization

KRT31 KRT33A KRT33B KRT34 KRT20 MACF1 PLEC

3.78e-06991347GO:0045104
GeneOntologyBiologicalProcessintermediate filament-based process

KRT31 KRT33A KRT33B KRT34 KRT20 MACF1 PLEC

4.04e-061001347GO:0045103
GeneOntologyBiologicalProcesscilium assembly

CEP162 SYNE1 SPEF2 CFAP43 ONECUT1 ACTR2 DNAH1 FSIP2 EXOC5 CEP250 SYNE2 CC2D2A DNAH5

6.67e-0644413413GO:0060271
GeneOntologyBiologicalProcessintermediate filament organization

KRT31 KRT33A KRT33B KRT34 KRT20 PLEC

9.37e-06751346GO:0045109
GeneOntologyBiologicalProcesscilium organization

CEP162 SYNE1 SPEF2 CFAP43 ONECUT1 ACTR2 DNAH1 FSIP2 EXOC5 CEP250 SYNE2 CC2D2A DNAH5

1.40e-0547613413GO:0044782
GeneOntologyBiologicalProcessplasma membrane bounded cell projection assembly

ATP7A CEP162 SYNE1 SPEF2 PPP1R9A CFAP43 ONECUT1 ACTR2 DNAH1 FSIP2 EXOC5 CEP250 SYNE2 CC2D2A DNAH5

3.10e-0567013415GO:0120031
GeneOntologyBiologicalProcesscell projection assembly

ATP7A CEP162 SYNE1 SPEF2 PPP1R9A CFAP43 ONECUT1 ACTR2 DNAH1 FSIP2 EXOC5 CEP250 SYNE2 CC2D2A DNAH5

3.99e-0568513415GO:0030031
GeneOntologyBiologicalProcessepithelial cilium movement involved in extracellular fluid movement

SPEF2 CFAP43 DNAH1 DNAH5 DNAH9

4.06e-05591345GO:0003351
GeneOntologyBiologicalProcessextracellular transport

SPEF2 CFAP43 DNAH1 DNAH5 DNAH9

5.16e-05621345GO:0006858
GeneOntologyBiologicalProcesssperm axoneme assembly

SPEF2 CFAP43 DNAH1 FSIP2

6.79e-05341344GO:0007288
GeneOntologyBiologicalProcesscilium movement involved in cell motility

DNAH3 SPEF2 KIAA0319L CFAP43 DNAH1 FSIP2 DNAH5 DNAH9

7.03e-052101348GO:0060294
GeneOntologyBiologicalProcessmucociliary clearance

SPEF2 CFAP43 DNAH9

7.31e-05131343GO:0120197
GeneOntologyBiologicalProcessaxoneme assembly

SPEF2 CFAP43 DNAH1 FSIP2 CC2D2A DNAH5

7.87e-051091346GO:0035082
GeneOntologyBiologicalProcesscilium-dependent cell motility

DNAH3 SPEF2 KIAA0319L CFAP43 DNAH1 FSIP2 DNAH5 DNAH9

8.28e-052151348GO:0060285
GeneOntologyBiologicalProcesscilium or flagellum-dependent cell motility

DNAH3 SPEF2 KIAA0319L CFAP43 DNAH1 FSIP2 DNAH5 DNAH9

8.28e-052151348GO:0001539
GeneOntologyBiologicalProcessdendritic spine organization

CAMK2B PPFIA2 PPP1R9A APOE ACTR2 HOMER1

1.06e-041151346GO:0097061
GeneOntologyBiologicalProcessresponse to toxic substance

ATP7A PPP1R9A APOE FAS TTPA ABCB1 TXNRD3 OSCP1 ABCC2

1.16e-042891349GO:0009636
GeneOntologyBiologicalProcessneuron projection organization

CAMK2B PPFIA2 PPP1R9A APOE ACTR2 HOMER1

1.83e-041271346GO:0106027
GeneOntologyBiologicalProcessregulation of oligodendrocyte apoptotic process

GAS6 AKAP12

2.49e-0441342GO:1900141
GeneOntologyBiologicalProcessmotile cilium assembly

SPEF2 CFAP43 DNAH1 FSIP2 CC2D2A

2.73e-04881345GO:0044458
GeneOntologyBiologicalProcessregulation of skeletal muscle adaptation

CAMK2B GTF2IRD2B GTF2IRD2

2.82e-04201343GO:0014733
GeneOntologyBiologicalProcesscerebrospinal fluid circulation

SPEF2 CFAP43 DNAH9

2.82e-04201343GO:0090660
GeneOntologyBiologicalProcesscilium movement

DNAH3 SPEF2 KIAA0319L CFAP43 DNAH1 FSIP2 DNAH5 DNAH9

3.12e-042611348GO:0003341
GeneOntologyBiologicalProcessdendrite morphogenesis

ATP7A CAMK2B SYNE1 PPFIA2 PPP1R9A ACTR2 TET1

3.17e-041981347GO:0048813
GeneOntologyBiologicalProcessregulation of dendritic spine development

CAMK2B PPFIA2 PPP1R9A APOE ACTR2

3.19e-04911345GO:0060998
GeneOntologyBiologicalProcessdendrite development

ATP7A CAMK2B SYNE1 PPFIA2 PPP1R9A APOE FAS ACTR2 TET1

3.48e-043351349GO:0016358
GeneOntologyBiologicalProcessmicrotubule bundle formation

SPEF2 CFAP43 DNAH1 FSIP2 CC2D2A DNAH5

3.73e-041451346GO:0001578
GeneOntologyBiologicalProcessvesicle tethering to Golgi

TRIP11 TBC1D23

4.14e-0451342GO:0099041
GeneOntologyBiologicalProcessorganelle assembly

MYH11 CEP162 SYNE1 SPEF2 KIAA0319L PUM2 CFAP43 ONECUT1 ACTR2 DNAH1 FSIP2 EXOC5 CEP250 SYNE2 CC2D2A PLEC DNAH5 VPS13B

4.14e-04113813418GO:0070925
GeneOntologyBiologicalProcesssperm flagellum assembly

SPEF2 CFAP43 DNAH1 FSIP2

4.82e-04561344GO:0120316
GeneOntologyCellularComponentaxonemal dynein complex

DNAH3 DNAH1 DNAH5 DNAH9

1.73e-05251324GO:0005858
GeneOntologyCellularComponentintermediate filament cytoskeleton

KRT31 KRT33A KRT33B KRT34 KRT222 SYNE2 KRT20 MACF1 PLEC

4.55e-052631329GO:0045111
GeneOntologyCellularComponentintermediate filament

KRT31 KRT33A KRT33B KRT34 KRT222 KRT20 MACF1 PLEC

9.92e-052271328GO:0005882
GeneOntologyCellularComponentdynein complex

DNAH3 DNAH1 DNAH5 DNAH9

3.76e-04541324GO:0030286
GeneOntologyCellularComponentsupramolecular fiber

DNAH3 MYH11 KRT31 KRT33A KRT33B KRT34 CEP162 SYNE1 APOE DNAH1 KRT222 SYNE2 KRT20 MACF1 PLEC DNAH5 DNAH9 HOMER1

4.47e-04117913218GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

DNAH3 MYH11 KRT31 KRT33A KRT33B KRT34 CEP162 SYNE1 APOE DNAH1 KRT222 SYNE2 KRT20 MACF1 PLEC DNAH5 DNAH9 HOMER1

4.85e-04118713218GO:0099081
GeneOntologyCellularComponentcluster of actin-based cell projections

MYH11 ATP7A PKHD1L1 FCHSD2 CEACAM16 PLEC ABCC2

5.46e-042231327GO:0098862
GeneOntologyCellularComponent9+2 motile cilium

DNAH3 SPEF2 CFAP43 DNAH1 FSIP2 DNAH5 DNAH9

8.02e-042381327GO:0097729
GeneOntologyCellularComponentcell leading edge

KLHL2 SLK ATP7A PPP1R9A EPB41L5 ACTR2 STX4 SYNE2 MACF1 ARHGAP45

1.30e-0350013210GO:0031252
GeneOntologyCellularComponentintercellular canaliculus

ABCB1 ABCC2

1.38e-0391322GO:0046581
GeneOntologyCellularComponentcilium

CCDC170 DNAH3 CEP162 SPEF2 CCDC178 CFAP43 DNAH1 FSIP2 VCAN CEP250 CC2D2A DNAH5 DNAH9 IQCE

1.64e-0389813214GO:0005929
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

DNAH3 KRT31 KRT33A KRT33B KRT34 CEP162 APOE DNAH1 KRT222 KRT20 MACF1 PLEC DNAH5 DNAH9

1.66e-0389913214GO:0099513
GeneOntologyCellularComponentinner dynein arm

DNAH3 DNAH1

1.72e-03101322GO:0036156
GeneOntologyCellularComponentaxoneme

DNAH3 CEP162 CFAP43 DNAH1 DNAH5 DNAH9

2.04e-032071326GO:0005930
GeneOntologyCellularComponentciliary plasm

DNAH3 CEP162 CFAP43 DNAH1 DNAH5 DNAH9

2.09e-032081326GO:0097014
GeneOntologyCellularComponentnuclear membrane protein complex

SYNE1 SYNE2

2.10e-03111322GO:0106083
GeneOntologyCellularComponentnuclear membrane microtubule tethering complex

SYNE1 SYNE2

2.10e-03111322GO:0106094
GeneOntologyCellularComponentmicrotubule organizing center attachment site

SYNE1 SYNE2

2.10e-03111322GO:0034992
GeneOntologyCellularComponenthemidesmosome

LAMA3 PLEC

2.10e-03111322GO:0030056
GeneOntologyCellularComponentmeiotic nuclear membrane microtubule tethering complex

SYNE1 SYNE2

2.10e-03111322GO:0034993
DomainKeratin_I

KRT31 KRT33A KRT33B KRT34 KRT222 KRT20

5.25e-07441286IPR002957
DomainDynein_heavy_chain_D4_dom

DNAH3 DNAH1 DNAH5 DNAH9

2.00e-06141284IPR024317
DomainDynein_HC_stalk

DNAH3 DNAH1 DNAH5 DNAH9

2.00e-06141284IPR024743
DomainDynein_heavy_dom-2

DNAH3 DNAH1 DNAH5 DNAH9

2.00e-06141284IPR013602
DomainDHC_N2

DNAH3 DNAH1 DNAH5 DNAH9

2.00e-06141284PF08393
DomainATPase_dyneun-rel_AAA

DNAH3 DNAH1 DNAH5 DNAH9

2.00e-06141284IPR011704
DomainMT

DNAH3 DNAH1 DNAH5 DNAH9

2.00e-06141284PF12777
DomainAAA_8

DNAH3 DNAH1 DNAH5 DNAH9

2.00e-06141284PF12780
DomainAAA_5

DNAH3 DNAH1 DNAH5 DNAH9

2.00e-06141284PF07728
DomainDHC_fam

DNAH3 DNAH1 DNAH5 DNAH9

2.71e-06151284IPR026983
DomainDynein_heavy

DNAH3 DNAH1 DNAH5 DNAH9

2.71e-06151284PF03028
DomainDynein_heavy_dom

DNAH3 DNAH1 DNAH5 DNAH9

2.71e-06151284IPR004273
DomainIntermediate_filament_CS

KRT31 KRT33A KRT33B KRT34 KRT222 KRT20

4.55e-06631286IPR018039
DomainLiprin

PPFIBP2 PPFIBP1 PPFIA2

6.19e-0661283IPR029515
DomainIF

KRT31 KRT33A KRT33B KRT34 KRT222 KRT20

9.94e-06721286PS00226
DomainFilament

KRT31 KRT33A KRT33B KRT34 KRT222 KRT20

1.08e-05731286PF00038
DomainIF

KRT31 KRT33A KRT33B KRT34 KRT222 KRT20

1.36e-05761286IPR001664
DomainACTININ_2

SYNE1 SYNE2 MACF1 PLEC

1.68e-05231284PS00020
DomainACTININ_1

SYNE1 SYNE2 MACF1 PLEC

1.68e-05231284PS00019
DomainActinin_actin-bd_CS

SYNE1 SYNE2 MACF1 PLEC

1.68e-05231284IPR001589
DomainSpectrin_repeat

SYNE1 SYNE2 MACF1 PLEC

4.38e-05291284IPR002017
DomainSPEC

SYNE1 SYNE2 MACF1 PLEC

6.52e-05321284SM00150
DomainSpectrin/alpha-actinin

SYNE1 SYNE2 MACF1 PLEC

6.52e-05321284IPR018159
DomainCH

SYNE1 SPEF2 SYNE2 MACF1 PLEC

1.45e-04731285PS50021
DomainCH-domain

SYNE1 SPEF2 SYNE2 MACF1 PLEC

1.64e-04751285IPR001715
DomainSAM_2

PPFIBP2 PPFIBP1 PPFIA2 PPP1R9A

2.11e-04431284PF07647
Domain-

GTF2IRD2B GTF2IRD2

2.77e-04412823.90.1460.10
DomainKASH

SYNE1 SYNE2

2.77e-0441282IPR012315
DomainSHR-BD

VPS13C VPS13B

2.77e-0441282IPR009543
DomainKASH

SYNE1 SYNE2

2.77e-0441282PS51049
DomainKASH

SYNE1 SYNE2

2.77e-0441282SM01249
DomainKASH

SYNE1 SYNE2

2.77e-0441282PF10541
DomainVPS13_C

VPS13C VPS13B

2.77e-0441282PF16909
DomainGTF2I

GTF2IRD2B GTF2IRD2

2.77e-0441282PS51139
DomainGTF2I

GTF2IRD2B GTF2IRD2

2.77e-0441282PF02946
DomainVPS13_C

VPS13C VPS13B

2.77e-0441282IPR031645
DomainGTF2I

GTF2IRD2B GTF2IRD2

2.77e-0441282IPR004212
DomainSHR-BD

VPS13C VPS13B

2.77e-0441282PF06650
DomainAutophagy-rel_C

VPS13C VPS13B

4.60e-0451282IPR015412
DomainATG_C

VPS13C VPS13B

4.60e-0451282PF09333
DomainSpectrin

SYNE1 SYNE2 MACF1

5.04e-04231283PF00435
Domain-

MACF1 PLEC

6.87e-04612823.90.1290.10
DomainPlectin

MACF1 PLEC

9.57e-0471282PF00681
DomainPlectin_repeat

MACF1 PLEC

9.57e-0471282IPR001101
DomainPLEC

MACF1 PLEC

9.57e-0471282SM00250
DomainCH

SYNE1 SYNE2 MACF1 PLEC

1.03e-03651284SM00033
DomainChorein_N

VPS13C VPS13B

1.27e-0381282PF12624
DomainDHC_N1

DNAH5 DNAH9

1.27e-0381282PF08385
DomainVPS13_N

VPS13C VPS13B

1.27e-0381282IPR026854
DomainDynein_heavy_dom-1

DNAH5 DNAH9

1.27e-0381282IPR013594
DomainCH

SYNE1 SYNE2 MACF1 PLEC

1.36e-03701284PF00307
DomainFilament

KRT31 KRT33A KRT33B KRT20

1.43e-03711284SM01391
Domain-

SYNE1 SYNE2 MACF1 PLEC

1.43e-037112841.10.418.10
DomainGRIP_dom

TRIP11 GOLGA4

2.94e-03121282IPR000237
DomainGRIP

TRIP11 GOLGA4

2.94e-03121282PS50913
DomainAAA

DNAH3 ABCB1 ABCC2 DNAH5 DNAH9

3.15e-031441285SM00382
DomainAAA+_ATPase

DNAH3 ABCB1 ABCC2 DNAH5 DNAH9

3.15e-031441285IPR003593
DomainSAM

PPFIBP2 PPFIBP1 PPFIA2 PPP1R9A

3.15e-03881284SM00454
DomainSAM_DOMAIN

PPFIBP2 PPFIBP1 PPFIA2 PPP1R9A

4.14e-03951284PS50105
DomainSAM

PPFIBP2 PPFIBP1 PPFIA2 PPP1R9A

4.46e-03971284IPR001660
Domain-

DNAH3 GBP7 SPEF2 SMC5 NLRC4 ABCB1 DNAH1 IDNK SEPTIN8 ABCC2 DNAH5 DNAH9

5.21e-03746128123.40.50.300
DomainP-loop_NTPase

DNAH3 MYH11 GBP7 SPEF2 SMC5 NLRC4 ABCB1 DNAH1 IDNK SEPTIN8 ABCC2 DNAH5 DNAH9

5.47e-0384812813IPR027417
Domain-

PPFIBP2 PPFIBP1 PPFIA2 PPP1R9A

6.10e-0310612841.10.150.50
DomainEGF-type_Asp/Asn_hydroxyl_site

GAS6 MMRN1 ADGRE3 VCAN

6.10e-031061284IPR000152
DomainLig_chan-Glu_bd

GRIK2 GRIN2D

6.64e-03181282PF10613
DomainGlu/Gly-bd

GRIK2 GRIN2D

6.64e-03181282IPR019594
DomainLig_chan-Glu_bd

GRIK2 GRIN2D

6.64e-03181282SM00918
DomainIontro_rcpt

GRIK2 GRIN2D

6.64e-03181282IPR001320
DomainIono_rcpt_met

GRIK2 GRIN2D

6.64e-03181282IPR001508
DomainLig_chan

GRIK2 GRIN2D

6.64e-03181282PF00060
DomainPBPe

GRIK2 GRIN2D

6.64e-03181282SM00079
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

PPFIBP2 PPFIBP1 PPFIA2 EPB41L5 GRIN2D HOMER1

5.06e-0667936MM15327
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

PPFIBP2 PPFIBP1 PPFIA2 EPB41L5 GRIN2D HOMER1

2.30e-0587936M27617
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH3 DNAH1 DNAH5 DNAH9

2.77e-0527934M47755
PathwayKEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT

DNAH3 DNAH1 DNAH5 DNAH9

1.80e-0443934M47669
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH3 DNAH1 DNAH5 DNAH9

2.15e-0445934M47670
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT31 KRT33A KRT33B KRT34 KRT20

2.70e-0487935MM15351
PathwayREACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES

PPFIBP2 PPFIBP1 PPFIA2

2.92e-0420933M27290
PathwayREACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES

PPFIBP2 PPFIBP1 PPFIA2

2.92e-0420933MM14991
PathwayREACTOME_NEURONAL_SYSTEM

KCNH8 PPFIBP2 PPFIBP1 CAMK2B PPFIA2 EPB41L5 GRIK2 GRIN2D HOMER1

3.62e-04335939MM14503
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SMG1 MYH11 CCDC185 KRT31 KRT33A KRT33B KRT34 CAMK2B SYNE1 PPFIA2 SPEF2 PPP1R9A ANKRD26 ZEB2 ACTR2 ABCB1 CCDC27 GTF2IRD2B TLK1 KIAA0825 SYNE2 GTF2IRD2 CC2D2A KRT20 MACF1 SMARCD2 EEA1 PLEC ABCC2 TMPRSS7 ZBTB11 HDGFL2 GOLGB1

1.15e-1614421363335575683
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

SLK TCOF1 PPFIBP1 PPP1R9A SMC5 TRIP11 AKAP12 MMRN1 MACF1 EEA1 PLEC GOLGA4 GOLGB1

1.94e-093601361333111431
Pubmed

Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation.

KRT31 KRT33A KRT33B KRT34

3.33e-096136410559501
Pubmed

Characterization of a 190-kilobase pair domain of human type I hair keratin genes.

KRT31 KRT33A KRT33B KRT34

2.78e-08913649756910
Pubmed

Human hair keratins.

KRT31 KRT33A KRT33B KRT34

2.78e-08913647686952
Pubmed

The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle.

KRT31 KRT33A KRT33B KRT34

4.61e-0810136410391933
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

KRT33A KRT33B VPS13C CCDC110 EPB41L5 EXOC5 PPP3R1 VCAN CC2D2A KRT20 EEA1 PLEC GOLGA4 GOLGB1

5.16e-085641361421565611
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MON2 SLK HDAC5 SYNE1 PPP1R9A PUM2 SMC5 ZEB2 FCHSD2 MACF1 SUZ12 VPS13B

7.72e-084071361212693553
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

SMG1 ATP7A PPFIBP2 PPFIBP1 VPS13C SYNE1 PPP1R9A EPB41L5 C2CD2 AKAP12 STX4 MACF1 SMARCD2 ABCC2 GOLGA4

1.60e-077191361535337019
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

SLK TRIM25 ANKRD26 EPB41L5 PUM2 SMC5 ZYX ACTR2 AKAP12 SEPTIN8 IGF2BP2 GKAP1 MACF1 SMARCD2 PLEC

1.75e-077241361536232890
Pubmed

New consensus nomenclature for mammalian keratins.

KRT31 KRT33A KRT33B KRT34 KRT222 KRT20

1.81e-0763136616831889
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

SMG1 HDAC5 PPFIBP1 SYNE1 PUM2 SMC5 TLK1 SYNE2 MACF1

2.78e-07225136912168954
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

ATP7A TCOF1 PPFIBP1 CEP162 VPS13C KIAA0319L ANKRD26 EPB41L5 TRIP11 PKHD1L1 AKAP12 AP4E1 GOLGA4 GOLGB1 IQCE

4.27e-077771361535844135
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

CAMK2B VPS13C SMC5 ACTR2 SEPTIN8 PTPRN2 VCAN CEP250 CCDC15 MACF1 HOMER1

1.11e-064301361132581705
Pubmed

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.

SYNE1 SYNE2 PLEC

1.16e-066136318827015
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SLK TCOF1 CAMK2B SYNE1 PPP1R9A GRIK2 GRIN2D TRIP11 ZEB2 AKAP12 PTPRN2 SYNE2 MACF1 HOMER1 GOLGA4 GOLGB1

1.24e-069631361628671696
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH3 DNAH1 DNAH5

2.02e-06713639256245
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

SLK TRIM25 PPFIBP1 VPS13C AHCTF1 TRIP11 C2CD2 ZYX AKAP12 SYNE2 VPS13B GOLGA4

2.60e-065681361237774976
Pubmed

CFAP43 modulates ciliary beating in mouse and Xenopus.

CFAP43 DNAH1 DNAH9

3.23e-068136331884020
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

SYNE1 CEP250 MACF1 EEA1 PLEC DNAH5 VPS13B GOLGB1

4.18e-06234136836243803
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

MON2 ATP7A PPFIBP1 VPS13C KIAA0319L TRIP11 AKAP12 SYNE2 VPS13B GOLGA4 GOLGB1

5.08e-065041361134432599
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

BDP1 CDH26 KCNH8 PPFIBP2 CAMK2B VPS13C PPFIA2 PPP1R9A GAS6 LAMA3 GRIK2 C2CD2 DNAH1 TLK1 PTPRN2 MACF1 VPS13B GOLGA4 GOLGB1

5.75e-0614891361928611215
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

ATP7A PPFIBP1 PPP1R9A ANKRD26 EPB41L5 TRIP11 AKAP12 KRT222 MACF1 GOLGB1

6.66e-064211361036976175
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

SLK CAMK2B SYNE1 PPP1R9A GRIK2 GRIN2D MACF1 HOMER1

6.99e-06251136827507650
Pubmed

Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS-Hook-FHIP complexes.

KIAA0319L TRIP11 AP4E1 TBC1D23 GOLGA4

9.63e-0672136534882091
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

AHCTF1 ANKRD26 EPB41L5 TRIP11 AP4E1 MACF1 VPS13B GOLGB1

9.82e-06263136834702444
Pubmed

Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.

SLK EPB41L5 TRIP11 C2CD2 AKAP12 SYNE2 GOLGB1

1.08e-05191136731177093
Pubmed

Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.

PPFIBP2 PPFIBP1 PPFIA2

1.25e-051213639624153
Pubmed

Differential effect of P-gp and MRP2 on cellular translocation of gemifloxacin.

ABCB1 ABCC2

1.52e-052136221864659
Pubmed

Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery.

MACF1 GOLGA4

1.52e-052136215265687
Pubmed

TRAIL deficiency contributes to diabetic nephropathy in fat-fed ApoE-/- mice.

TNFSF10 APOE

1.52e-052136224667560
Pubmed

Cysteine cathepsins are not critical for TRAIL- and CD95-induced apoptosis in several human cancer cell lines.

TNFSF10 FAS

1.52e-052136223667901
Pubmed

Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.

SYNE1 SYNE2

1.52e-052136211792814
Pubmed

Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice.

ABCB1 ABCC2

1.52e-052136216611851
Pubmed

Expression of TRAIL and Fas in Primary Hyperparathyroidism.

TNFSF10 FAS

1.52e-052136227763797
Pubmed

Influence of polymorphisms of ABCB1 and ABCC2 on mRNA and protein expression in normal and cancerous kidney cortex.

ABCB1 ABCC2

1.52e-052136216788565
Pubmed

Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension.

TNFSF10 APOE

1.52e-052136223071256
Pubmed

Hypercholesterolemia Accelerates the Aging Phenotypes of Hematopoietic Stem Cells by a Tet1-Dependent Pathway.

APOE TET1

1.52e-052136232107419
Pubmed

Nesprins: tissue-specific expression of epsilon and other short isoforms.

SYNE1 SYNE2

1.52e-052136224718612
Pubmed

Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.

SYNE1 SYNE2

1.52e-052136224586179
Pubmed

Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.

SYNE1 SYNE2

1.52e-052136217761684
Pubmed

Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.

SYNE1 SYNE2

1.52e-052136231578382
Pubmed

TET1s deficiency exacerbates oscillatory shear flow-induced atherosclerosis.

APOE TET1

1.52e-052136235342333
Pubmed

Association between the polymorphisms in the ATP-binding cassette genes ABCB1 and ABCC2 and the risk of drug-resistant epilepsy in a Chinese Han population.

ABCB1 ABCC2

1.52e-052136227886333
Pubmed

Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.

GTF2IRD2B GTF2IRD2

1.52e-052136215388857
Pubmed

Linkage disequilibrium between polymorphisms of ABCB1 and ABCC2 to predict the treatment outcome of Malaysians with complex partial seizures on treatment with carbamazepine mono-therapy at the Kuala Lumpur Hospital.

ABCB1 ABCC2

1.52e-052136223717663
Pubmed

Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCC2 and their impact on drug disposition.

ABCB1 ABCC2

1.52e-052136221039333
Pubmed

Further evidence for role of a promoter variant in the TNFRSF6 gene in Alzheimer disease.

APOE FAS

1.52e-052136212497631
Pubmed

ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia.

APOE FAS

1.52e-052136217259598
Pubmed

Fas and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Are Closely Linked to the Levels of Glycated and Fetal Hemoglobin in Patients with Diabetes Mellitus.

TNFSF10 FAS

1.52e-052136229739045
Pubmed

Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.

SYNE1 SYNE2

1.52e-052136224931616
Pubmed

ABCC2 haplotype is not associated with drug-resistant epilepsy.

ABCB1 ABCC2

1.52e-052136218416940
Pubmed

P-glycoprotein is not involved in pathway of anti-Fas/Fas-induced apoptosis in KBv200 cells.

FAS ABCB1

1.52e-052136215962371
Pubmed

Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells.

TET1 SUZ12

1.52e-052136223987249
Pubmed

Apolipoprotein E-knockout mice on high-fat diet show autoimmune injury on kidney and aorta.

APOE FAS

1.52e-052136224953693
Pubmed

Circular RNA circPBX3 promotes cisplatin resistance of ovarian cancer cells via interacting with IGF2BP2 to stabilize ATP7A mRNA expression.

ATP7A IGF2BP2

1.52e-052136235907138
Pubmed

An association study of 43 SNPs in 16 candidate genes with atorvastatin response.

APOE ABCB1

1.52e-052136216103896
Pubmed

The important role of Bcrp (Abcg2) in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in mice.

ABCB1 ABCC2

1.52e-052136216959944
Pubmed

Differential expression of type I hair keratins.

KRT33A KRT33B

1.52e-05213621689759
Pubmed

Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.

SYNE1 SYNE2

1.52e-052136222768332
Pubmed

Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E.

APOE TTPA

1.52e-052136211095717
Pubmed

Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.

SYNE1 SYNE2

1.52e-052136217267447
Pubmed

Novel autosomal recessive LAMA3 and PLEC variants underlie junctional epidermolysis bullosa generalized intermediate and epidermolysis bullosa simplex with muscular dystrophy in two consanguineous families.

LAMA3 PLEC

1.52e-052136229797489
Pubmed

ABCB1 and SLCO1B1 gene polymorphisms predict methotrexate-resistant for low-risk gestational trophoblastic neoplasia.

APOE ABCB1

1.52e-052136233565324
Pubmed

Protective effect of vitamin E supplements on experimental atherosclerosis is modest and depends on preexisting vitamin E deficiency.

APOE TTPA

1.52e-052136216895792
Pubmed

A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms.

KRT33A KRT33B

1.52e-05213627565656
Pubmed

The potential role of human multidrug resistance protein 1 (MDR1) and multidrug resistance-associated protein 2 (MRP2) in the transport of Huperzine A in vitro.

ABCB1 ABCC2

1.52e-052136231132291
Pubmed

TNF-related apoptosis-inducing ligand (TRAIL) protects against diabetes and atherosclerosis in Apoe ⁻/⁻ mice.

TNFSF10 APOE

1.52e-052136221965021
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

SLK TRIM25 TCOF1 AHCTF1 ANKRD26 PUM2 ICE1 TRIP11 ZYX AKAP12 IGF2BP2 MACF1 HDGFL2 GOLGB1

1.89e-059341361433916271
Pubmed

Sequence and expression of murine type I hair keratins mHa2 and mHa3.

KRT33A KRT33B KRT34

2.06e-051413637514534
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH3 DNAH1 DNAH5

2.06e-051413639373155
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

ATP7A TRIM25 TCOF1 PPFIBP1 SYNE1 AHCTF1 ANKRD26 EPB41L5 AKAP12 EXOC5 SYNE2 GKAP1 MACF1 HDGFL2 MRPL9 VPS13B GOLGA4 GOLGB1

2.09e-0514871361833957083
Pubmed

A human MAP kinase interactome.

MYH11 SYNE1 LAMA3 ZYX TLK1 CEP250 KRT20 MACF1 PLEC GOLGB1

2.29e-054861361020936779
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

PPFIBP1 CFAP43 ZYX DNAH1 PTPRN2 MROH7 MACF1 TRMT1L PLEC UNC5D

2.72e-054961361031343991
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PPFIBP1 CEP162 ANKRD26 EPB41L5 TRIP11 ZYX FSIP2 SYNE2 TET1 MACF1 PLEC GOLGA4 GOLGB1

3.53e-058611361336931259
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

DNAH3 KCNH8 SYNE1 TBC1D8B AKAP12 SEPTIN8 IQCE

3.88e-05233136737704626
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

OXR1 TCOF1 PPFIBP1 SYNE1 KIAA0319L ZNF521 APOE TRIP11 ZEB2 PPP3R1 KRT222 CCDC15 MACF1 PLEC TBC1D23 ZBTB11

4.47e-0512851361635914814
Pubmed

Disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in relation to ABC transporter genotypes.

ABCB1 ABCC2

4.54e-053136216505951
Pubmed

Contribution of child ABC-transporter genetics to prenatal MeHg exposure and neurodevelopment.

ABCB1 ABCC2

4.54e-053136235654246
Pubmed

The ABCB1, ABCC2 and RALBP1 polymorphisms are associated with carbamazepine response in epileptic patient: a systematic review.

ABCB1 ABCC2

4.54e-053136235325436
Pubmed

Increased serum sFas, sTRAIL, and reduced sFasL in juvenile-onset systemic lupus erythematosus.

TNFSF10 FAS

4.54e-053136228378099
Pubmed

Inhibition of P-glycoprotein and multidrug resistance-associated proteins modulates the intracellular concentration of lopinavir in cultured CD4 T cells and primary human lymphocytes.

ABCB1 ABCC2

4.54e-053136217890284
Pubmed

Common variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes among women with advanced stage ovarian cancer treated with platinum and taxane-based chemotherapy: a Gynecologic Oncology Group study.

ABCB1 ABCC2

4.54e-053136222112610
Pubmed

Evaluation of apoptosis-related genes: Fas (CD94), FasL (CD178) and TRAIL polymorphisms in Iranian multiple sclerosis patients.

TNFSF10 FAS

4.54e-053136221864851
Pubmed

Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress.

ATP7A APOE

4.54e-053136216371425
Pubmed

Circulating levels of soluble apoptosis-related molecules in patients with multiple sclerosis.

TNFSF10 FAS

4.54e-053136223932896
Pubmed

Accumulation of murine amyloid-β mimics early Alzheimer's disease.

ABCB1 MMEL1

4.54e-053136225991605
Pubmed

The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.

SYNE1 SYNE2

4.54e-053136216079285
Pubmed

Effects of the scaffold proteins liprin-α1, β1 and β2 on invasion by breast cancer cells.

PPFIBP2 PPFIBP1

4.54e-053136226663347
Pubmed

Zinc finger nuclease-mediated gene knockout results in loss of transport activity for P-glycoprotein, BCRP, and MRP2 in Caco-2 cells.

ABCB1 ABCC2

4.54e-053136225388687
Pubmed

Telmisartan pharmacokinetics in Japanese renal transplant recipients.

ABCB1 ABCC2

4.54e-053136218838068
Pubmed

TRIB2 knockdown as a regulator of chemotherapy resistance and proliferation via the ERK/STAT3 signaling pathway in human chronic myelogenous leukemia K562/ADM cells.

TRIB2 ABCB1

4.54e-053136229436678
Pubmed

Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.

ABCB1 ABCC2

4.54e-053136224334255
Pubmed

Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.

SYNE1 SYNE2

4.54e-053136210878022
Pubmed

A genetic risk score is significantly associated with statin therapy response in the elderly population.

APOE ABCC2

4.54e-053136227943270
Pubmed

The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.

SYNE1 SYNE2

4.54e-053136212408964
Pubmed

Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.

GTF2IRD2B GTF2IRD2

4.54e-053136215100712
Pubmed

Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.

SYNE1 SYNE2

4.54e-053136217462627
Pubmed

CD36/fatty acid translocase, an inflammatory mediator, is involved in hyperlipidemia-induced exacerbation in ischemic brain injury.

APOE DNAH5

4.54e-053136218448643
Pubmed

The calcineurin B subunit (CnB) is a new ligand of integrin αM that mediates CnB-induced Apo2L/TRAIL expression in macrophages.

TNFSF10 PPP3R1

4.54e-053136222116828
InteractionRAB4A interactions

MON2 ATP7A OXR1 VPS13C SYNE1 KIAA0319L EPB41L5 TRIP11 AP4E1 EXOC5 STX4 SYNE2 EEA1 VPS13B GOLGA4 GOLGB1

5.33e-0845713216int:RAB4A
InteractionSTX6 interactions

MON2 TRIM25 PPFIBP1 KIAA0319L ANKRD26 EPB41L5 TRIP11 AKAP12 AP4E1 STX4 MACF1 EEA1 VPS13B GOLGA4 GOLGB1

2.54e-0744813215int:STX6
InteractionGOLGA1 interactions

MON2 TRIM25 KIAA0319L ANKRD26 AP4E1 MACF1 TBC1D23 GOLGA4 GOLGB1

3.35e-061831329int:GOLGA1
InteractionPLEC interactions

DNAH3 RIN3 SLK KRT34 SPEF2 AHCTF1 CCDC27 KRT222 SYNE2 MACF1 SUZ12 PLEC DNAH5

5.12e-0643013213int:PLEC
InteractionGJD3 interactions

MON2 ATP7A PPFIBP1 VPS13C SYNE1 KIAA0319L ANKRD26 EPB41L5 TRIP11 SYNE2 VPS13B GOLGA4 GOLGB1

9.18e-0645413213int:GJD3
InteractionGBP7 interactions

GBP7 SYNE2 GOLGA4

1.50e-0581323int:GBP7
InteractionRHOD interactions

SLK TRIM25 PPFIBP1 PPP1R9A KIAA0319L ANKRD26 EPB41L5 C2CD2 AKAP12 STX4 SYNE2 MACF1 GOLGA4 GOLGB1

2.38e-0557213214int:RHOD
InteractionSTX7 interactions

MON2 ATP7A OXR1 PPFIBP1 ANKRD26 EPB41L5 TRIP11 AKAP12 AP4E1 EXOC5 STX4 SYNE2 EEA1 GOLGA4 GOLGB1

2.79e-0565913215int:STX7
InteractionGJA1 interactions

MON2 ATP7A PPFIBP1 KIAA0319L ANKRD26 EPB41L5 TRIP11 AP4E1 STX4 SYNE2 MACF1 VPS13B GOLGA4 GOLGB1

2.93e-0558313214int:GJA1
InteractionCXADR interactions

MON2 PPFIBP1 PPP1R9A ANKRD26 EPB41L5 TRIP11 STX4 SYNE2 MACF1 VPS13B GOLGB1

3.20e-0536913211int:CXADR
InteractionFHIP2A interactions

KLHL2 KIAA0319L TRIP11 TBC1D23 GOLGA4

3.26e-05561325int:FHIP2A
InteractionKRT8 interactions

SMG1 KRT31 KRT33A KRT33B KRT34 CEP162 AHCTF1 ANKRD26 FAS TRIP11 KRT20 PLEC

3.39e-0544113212int:KRT8
InteractionDNAJC5 interactions

ATP7A TRIM25 PPFIBP1 ANKRD26 EPB41L5 FAS EXOC5 STX4 MACF1 GOLGA4 GOLGB1

3.99e-0537813211int:DNAJC5
InteractionCROCC interactions

UBR1 TRIM25 SYNE1 CEP250 KRT222

4.21e-05591325int:CROCC
InteractionYWHAZ interactions

BDP1 RIN3 SLK MYH11 TRIM25 HDAC5 PPFIBP2 PPFIBP1 CAMK2B CEP162 PPFIA2 ANKRD26 APOE SMC5 ACTR2 FSIP2 EXOC5 SYNE2 MACF1 DEPDC5 PLEC HOMER1

4.52e-05131913222int:YWHAZ
InteractionPPIA interactions

SLC25A24 TRIM25 HDAC5 KRT31 KRT33A SPEF2 EPB41L5 SMC5 ACTR2 PPP3R1 MACF1 SMARCD2 TRMT1L DNAH9 HDGFL2 HOMER1 GOLGA4

7.03e-0588813217int:PPIA
InteractionSIK2 interactions

SMG1 MYH11 TRIM25 HDAC5 ACTR2 CEP250

7.03e-051061326int:SIK2
InteractionLAMP3 interactions

ATP7A PPFIBP1 VPS13C AHCTF1 EPB41L5 TRIP11 AKAP12 ABCB1 SYNE2 EEA1 GOLGA4 GOLGB1

8.61e-0548613212int:LAMP3
InteractionRPS10-NUDT3 interactions

RIN3 TRIM25 SMC5

9.48e-05141323int:RPS10-NUDT3
InteractionARL15 interactions

UBR1 ATP7A PPFIBP1 EPB41L5 AKAP12 GOLGA4

1.00e-041131326int:ARL15
InteractionRAB11A interactions

MON2 OXR1 PPFIBP1 VPS13C ANKRD26 EPB41L5 TRIP11 AKAP12 ABCB1 AP4E1 EXOC5 STX4 SYNE2 VPS13B GOLGA4 GOLGB1

1.08e-0483013216int:RAB11A
InteractionRHOC interactions

SLK ATP7A PPFIBP1 PPP1R9A ANKRD26 EPB41L5 TRIP11 C2CD2 SYNE2 MACF1 VPS13B GOLGA4 GOLGB1

1.23e-0458413213int:RHOC
InteractionWHAMMP3 interactions

THAP5 ATP7A SYNE1 SEPTIN8 EXOC5 CEP250

1.33e-041191326int:WHAMMP3
InteractionKRT86 interactions

UBR1 KRT31 KRT33B KRT34 CAMK2B

1.34e-04751325int:KRT86
InteractionRAC2 interactions

PPFIBP1 PPP1R9A KIAA0319L EPB41L5 TRIP11 C2CD2 AKAP12 FHAD1 STX4 SYNE2 MACF1 VPS13B GOLGA4 GOLGB1

1.38e-0467413214int:RAC2
InteractionKRT6C interactions

KRT31 KRT33B KRT34 KRT20 PLEC

1.42e-04761325int:KRT6C
InteractionSLC6A4 interactions

CAMK2B VPS13C SMC5 ACTR2 SEPTIN8 PTPRN2 VCAN CEP250 CCDC15 MACF1 HOMER1

1.45e-0443713211int:SLC6A4
InteractionZFPL1 interactions

MON2 PPFIBP1 ANKRD26 EPB41L5 TRIP11 AKAP12 AP4E1 STX4 VPS13B GOLGA4 GOLGB1

1.80e-0444813211int:ZFPL1
Cytoband17q21.2

KRT33B KRT34 KRT222 KRT20

5.80e-0570136417q21.2
Cytoband2p22-p21

PUM2 NLRC4

2.41e-04813622p22-p21
CytobandEnsembl 112 genes in cytogenetic band chr17q21

HDAC5 KRT31 KRT33A KRT33B KRT34 KRT222 KRT20

5.50e-044731367chr17q21
GeneFamilyKeratins, type I

KRT31 KRT33A KRT33B KRT34 KRT20

1.73e-0728845608
GeneFamilyDyneins, axonemal

DNAH3 DNAH1 DNAH5 DNAH9

9.85e-0717844536
GeneFamilySpectrin repeat containing nuclear envelope family

SYNE1 SYNE2

1.27e-0448421252
GeneFamilyEF-hand domain containing|Plakins

MACF1 PLEC

5.86e-048842939
GeneFamilySterile alpha motif domain containing

PPFIBP2 PPFIBP1 PPFIA2 PPP1R9A

7.51e-0488844760
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

SLC25A24 SLK AHCTF1 PUM2 SMC5 C2CD2 ZEB2 FCHSD2 TLK1 PPP3R1 SYNE2 MACF1 SUZ12 ZBTB11 HOMER1 VPS13B GOLGA4

2.05e-0685613517M4500
CoexpressionDESCARTES_FETAL_STOMACH_CILIATED_EPITHELIAL_CELLS

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 KIAA0825 CC2D2A OSCP1 DNAH5 DNAH9

6.03e-0631713510M40298
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

BDP1 UBR1 SMG1 SLK TRIB2 VPS13C SYNE1 SPEF2 PUM2 ICE1 SMC5 ITGAE FAS ZEB2 ZYX ACTR2 ABCB1 TLK1 MACF1 SUZ12 ARHGAP45 VPS13B

7.75e-06149213522M40023
CoexpressionGSE21546_WT_VS_SAP1A_KO_AND_ELK1_KO_DP_THYMOCYTES_UP

SMG1 ATP7A GBP7 KRT33A ZEB2 ABCB1 TMEM132E HOMER1

9.67e-062001358M7529
CoexpressionAIZARANI_LIVER_C20_LSECS_3

BDP1 PPFIBP1 AHCTF1 ZEB2 AKAP12 MACF1 EEA1 GOLGA4 GOLGB1

2.32e-052951359M39121
CoexpressionDESCARTES_FETAL_LUNG_CILIATED_EPITHELIAL_CELLS

CCDC170 DNAH3 CDH26 SPEF2 CFAP43 DNAH1 FHAD1 CC2D2A OSCP1 TMPRSS7 DNAH5 DNAH9

2.41e-0554013512M40241
CoexpressionMENON_FETAL_KIDNEY_5_PROXIMAL_TUBULE_CELLS

TNFSF10 PPFIBP1 SPEF2 APOE VCAN SYNE2

2.55e-051121356M39255
CoexpressionLAKE_ADULT_KIDNEY_C4_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S2

BDP1 OXR1 PPFIBP1 PPP1R9A ANKRD26 AKAP12 SYNE2

3.67e-051761357M39223
CoexpressionTRAVAGLINI_LUNG_CILIATED_CELL

CCDC170 DNAH3 CEP162 SYNE1 SPEF2 ANKRD26 CFAP43 DNAH1 FHAD1 IGF2BP2 PTPRN2 SYNE2 CC2D2A OSCP1 DNAH5 DNAH9 IQCE

4.83e-05109313517M41649
CoexpressionDESCARTES_MAIN_FETAL_CILIATED_EPITHELIAL_CELLS

CCDC170 DNAH3 SPEF2 CCDC178 CFAP43 DNAH1 FHAD1 KIAA0825 CC2D2A OSCP1 DNAH5 DNAH9 IQCE

5.04e-0567813513M40124
CoexpressionGSE29949_CD8_NEG_DC_SPLEEN_VS_DC_BRAIN_UP

MYH11 KRT33A APOE DEPDC5 ABCC2 DNAH9 IQCE

6.58e-051931357M8394
CoexpressionGSE28726_ACT_CD4_TCELL_VS_ACT_VA24NEG_NKTCELL_DN

TRIB2 HDAC5 SYNE1 FCHSD2 SYNE2 ARHGAP45 VPS13B

8.23e-052001357M8306
CoexpressionGSE17186_BLOOD_VS_CORD_BLOOD_CD21HIGH_TRANSITIONAL_BCELL_DN

OXR1 ANKRD26 FAS AKAP12 IDNK IGF2BP2 ARHGAP45

8.23e-052001357M7186
CoexpressionGSE21774_CD56_BRIGHT_VS_DIM_CD62L_POSITIVE_NK_CELL_UP

SLC25A24 TRIB2 EPB41L5 TBC1D8B MMRN1 SEPTIN8 ZBTB11

8.23e-052001357M7489
CoexpressionGSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP

EXOC5 FCHSD2 TLK1 GKAP1 SMARCD2 MSANTD4 HOMER1

8.23e-052001357M5623
CoexpressionWOOD_EBV_EBNA1_TARGETS_DN

ACTR2 AKAP12 MACF1 GOLGA4

1.10e-04481354M19460
CoexpressionGAO_ESOPHAGUS_25W_C1_CILIATED_EPITHELIAL_CELLS

CCDC170 CEP162 SYNE1 SPEF2 CFAP43 DNAH1 FHAD1 MACF1 DNAH5 DNAH9

1.38e-0445913510M39136
CoexpressionGSE14415_NATURAL_TREG_VS_FOXP3_KO_NATURAL_TREG_UP

BDP1 MYH11 SYNE1 APOE ZEB2 HOMER1

1.40e-041521356M2964
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

BDP1 SLK VPS13C AHCTF1 TRIP11 SYNE2 GKAP1 SUZ12 EEA1 ZBTB11 GOLGA4 GOLGB1

1.54e-0465613512M18979
CoexpressionSIRNA_EIF4GI_DN

ITGAE C2CD2 FCHSD2 IGF2BP2 MRPL9

1.56e-04981355M2846
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 SYNE1 SPEF2 ANKRD26 CFAP43 FHAD1 IGF2BP2 KIAA0825 SYNE2 DNAH5 DNAH9

2.59e-111971361174a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC170 DNAH3 SPEF2 FHAD1 GOLGA6L22 CC2D2A OSCP1 DNAH5 DNAH9 IQCE

3.62e-1018913610b4b93bd10b7e3cc16e54ff73beac230f519c010a
ToppCellNasal_Brush-Epithelial-Ciliated_2|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

3.81e-10190136109ce7df056bfb24d70db4c3c4a2c57d89115de877
ToppCellNasal_Brush-Epithelial-Ciliated_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

3.81e-1019013610833481ace2800354712e2ce709d5cdfd0aed3d42
ToppCellNS-control-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

5.16e-1019613610d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCellPSB-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

5.43e-10197136106865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

5.43e-101971361091637bdeab85024b5a02d1066f76cb803a2d6420
ToppCellNS-moderate-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

5.43e-101971361071fea4aa6ce96c7693fa94792d08770622873850
ToppCellcontrol-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

5.43e-1019713610e453d085182364ca347cbcc9dc995c62c3353016
ToppCellcontrol-Epithelial-Ciliated|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

5.43e-1019713610d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

VPS13C ANKRD26 TRIP11 FHAD1 SYNE2 SUZ12 EEA1 DNAH5 GOLGA4 GOLGB1

5.99e-1019913610fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

MON2 SMG1 VPS13C AHCTF1 ZEB2 SYNE2 MACF1 ZBTB11 GOLGB1

6.79e-091881369ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

8.16e-091921369be592e661367affced9ebe80849b466e6adb3a34
ToppCellCiliated-cil-3|World / Class top

DNAH3 CDH26 SYNE1 SPEF2 CFAP43 DNAH1 FHAD1 DNAH5 DNAH9

8.16e-0919213694989ebb8812b8af1870599acd932849122c05a29
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 KIAA0825 DNAH5 DNAH9

8.54e-091931369ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

8.54e-0919313690b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCellBronchial_Brush-Epithelial-Ciliated_1|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

CCDC170 SYNE1 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

8.93e-091941369b4ce60c06568123008b1081d644733cb91c28f51
ToppCellBronchial_Brush-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

CCDC170 SYNE1 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

8.93e-0919413697a7ddccfe72a4a0dc4d1a5c809988f0069f9f1a3
ToppCellASK452-Epithelial-Ciliated|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

8.93e-0919413695aeb44657ab6f61b1abf98af28d3397d8e44c1aa
ToppCellNS-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

9.34e-09195136934e37cff4849696ca4ba5dd8fd2cf98fed8bc912
ToppCellBL-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

9.34e-09195136907a6bcef6af93ed87df455dee624037cb75e011a
ToppCellcritical-Epithelial-Ciliated|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

9.77e-09196136927b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.02e-08197136922c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.02e-0819713693bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.02e-08197136987db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCellcritical-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

1.07e-081981369ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

CEP162 VPS13C ANKRD26 TRIP11 TLK1 SYNE2 SUZ12 GOLGA4 GOLGB1

1.07e-08198136976d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MON2 BDP1 SMG1 SYNE1 SYNE2 MACF1 VPS13B GOLGA4 GOLGB1

1.11e-081991369f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

CEP162 VPS13C ANKRD26 TRIP11 FHAD1 SYNE2 EEA1 GOLGA4 GOLGB1

1.11e-08199136961b1ed2db71b96157b92b7535d1955a4033098da
ToppCellBiopsy_IPF-Epithelial-Ciliated|Biopsy_IPF / Sample group, Lineage and Cell type

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

1.16e-082001369bb8c99156e547a8eb6599b6b6bc3c66bf77af7f8
ToppCell(09)_Interm._secr.>cil.|World / shred by cell type by condition

CCDC170 SYNE1 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

1.16e-0820013693305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

5.01e-081681368fa7c0303918cea04e3f4c4f3cb079be19004d214
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

5.01e-0816813687edcab103c69e928d5c19a0d218ffb3ae32f9e70
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC170 DNAH3 SPEF2 FHAD1 GOLGA6L22 CC2D2A DNAH5 DNAH9

8.54e-0818013681f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 CC2D2A DNAH5 DNAH9

1.10e-07186136876033438426d8f9c72cd6691a7baf92104c9f03d
ToppCell21-Trachea-Epithelial-Intermediate_ciliated|Trachea / Age, Tissue, Lineage and Cell class

CCDC170 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

1.15e-0718713681a2178a195d078d1963947b327c6d0d4f2f48341
ToppCellEpithelial-Epithelial-D_(Ciliated)|Epithelial / shred on cell class and cell subclass (v4)

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 DNAH5 DNAH9

1.19e-0718813688f30535a32968a81a304315a49c0d90a77d36948
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TNFSF10 PPFIBP1 PPP1R9A ABCB1 IGF2BP2 VCAN SYNE2 UNC5D

1.24e-07189136828b502611829e4a24caff2562545c7db97686099
ToppCellCOPD-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 KIAA0825 DNAH5 DNAH9

1.24e-0718913683e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCellASK428-Epithelial-Ciliated|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.35e-0719113680c4b926a28bc94f3cf4d68a911c0a189f6ff505e
ToppCellASK452-Epithelial-Ciliated|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

CCDC170 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

1.46e-071931368c0d10075862ac878aa05fc49c8b73e470783bf16
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 CC2D2A DNAH5 DNAH9

1.46e-071931368e1b76102f812c433195d1e8811fdd3293a7bc22e
ToppCellControl-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 KIAA0825 DNAH5 DNAH9

1.46e-0719313680e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell15-Trachea-Epithelial-Multiciliated_cell|Trachea / Age, Tissue, Lineage and Cell class

CCDC170 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

1.46e-071931368aa3acc7571405169efb656d214f3a8cbf988362e
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 DNAH5 DNAH9

1.52e-0719413684a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.58e-0719513680e763f36786515698b593e5c93f6a56619c1242d
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.58e-071951368581b04220587e1d5198b1abd6965965ace7803e7
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.58e-07195136893b1559382a12cfb158aa5fac7386e38b4f87989
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 CC2D2A DNAH5 DNAH9

1.58e-0719513683486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCellCOVID-19-Epithelial-Ciliated_cells|Epithelial / Condition, Lineage and Cell class

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.64e-071961368de7aa31354b019d7321a8ef965d59ce2e8b89276
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated-diff|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CCDC170 SPEF2 CFAP43 FHAD1 CC2D2A OSCP1 DNAH5 DNAH9

1.64e-0719613689a91a6e5f93ce3bb5a0fc63677553f4c2df95c43
ToppCell356C-Endothelial_cells-Endothelial-F_(Lymphatics)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PPFIBP2 PPFIBP1 SYNE1 PPP1R9A PKHD1L1 AKAP12 MMRN1 GKAP1

1.64e-071961368b04ca69b0ed44e09c989b575f747e1e819cd8008
ToppCell356C-Endothelial_cells-Endothelial-F_(Lymphatics)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PPFIBP2 PPFIBP1 SYNE1 PPP1R9A PKHD1L1 AKAP12 MMRN1 GKAP1

1.64e-071961368a31e227de2dc077b81881295b012d22fedbd65ed
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

PPFIBP1 ANKRD26 TRIP11 AKAP12 SYNE2 EEA1 GOLGA4 GOLGB1

1.85e-071991368a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCell(10)_Ciliated|World / shred by cell type by condition

CCDC170 SYNE1 SPEF2 CFAP43 CC2D2A OSCP1 DNAH5 DNAH9

1.92e-0720013681b6a8025bd2746b626040058c122b1be3ab2fa61
ToppCellBiopsy_Control_(H.)-Epithelial-Ciliated|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.92e-0720013689ae434c78e08adf95da49c85616e3ca72d1227bf
ToppCellBronchus_Control_(B.)-Epithelial-TX-Ciliated|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

CCDC170 DNAH3 SYNE1 SPEF2 CFAP43 FHAD1 DNAH5 DNAH9

1.92e-0720013686a2ccc71a0cbe04a542c379b28b5006de53981c3
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CCDC170 DNAH3 SPEF2 CFAP43 DNAH1 FHAD1 DNAH5 DNAH9

1.92e-07200136831d75c26055177d656df1fbb10b764cebd61e122
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_ciliated|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.92e-0720013687cb3e3bd9e851ccb096e0a3471819471d85ebace
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CCDC170 DNAH3 SPEF2 CFAP43 DNAH1 FHAD1 DNAH5 DNAH9

1.92e-072001368e1dce91c6c531bb212002a14705e496d77ad3490
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BDP1 SMG1 VPS13C ZEB2 SYNE2 MACF1 GOLGA4 GOLGB1

1.92e-07200136812f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Ciliated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.92e-072001368f1a49bc818054fb0734d3b84725ee6487b034567
ToppCellParenchyma_COVID-19-Epithelial-TX-Ciliated|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.92e-072001368d7ae09189cf0b7e2f7e7fc6b0921975b75aa7d62
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_ciliated-Ciliated|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.92e-0720013688441e289377215a6877640946fe3f6de1f456502
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Ciliated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.92e-072001368cf59110547cc66b5f4a2999735336b0309ba9b0d
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC170 DNAH3 CFAP43 DNAH1 FHAD1 DNAH5 DNAH9

4.84e-0715413674e3bc24043144143842627cacf6f90dda2228910
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC170 DNAH3 CFAP43 DNAH1 OSCP1 DNAH5 DNAH9

4.84e-0715413679ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC170 DNAH3 CFAP43 DNAH1 FHAD1 DNAH5 DNAH9

4.84e-0715413677556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC170 DNAH3 CFAP43 DNAH1 OSCP1 DNAH5 DNAH9

4.84e-07154136758072ce422d09f2de602580325eaac6c4ec6c136
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH11 PPFIA2 GRIK2 PKHD1L1 CCDC7 PLD5 DNAH9

6.26e-071601367c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH11 PPFIA2 GRIK2 PKHD1L1 CCDC7 PLD5 DNAH9

6.26e-07160136725c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC170 DNAH3 CDH26 CFAP43 DNAH1 DNAH5 DNAH9

7.40e-071641367e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCellEndothelial-B-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

PPFIBP1 ZNF521 PKHD1L1 AKAP12 MMRN1 KRT222 UNC5D

8.70e-0716813674977c3837fbb1f36c89fddd5764e37290ac25ad8
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 SPEF2 CFAP43 DNAH1 FHAD1 KIAA0825 DNAH9

9.05e-071691367fba841664939c771881ba97f14ef1df6635c04ff
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 DNAH5 DNAH9

9.05e-07169136714aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC170 DNAH3 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.06e-061731367c3762655caa79ac4879876f470d32578a3c93b01
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma|PND07-28-samps / Age Group, Lineage, Cell class and subclass

CCDC170 SPEF2 CFAP43 DNAH1 FHAD1 DNAH5 DNAH9

1.10e-061741367f41d05a3703d7092bd3c4a97c15ae13069aaa4ad
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar|PND07-28-samps / Age Group, Lineage, Cell class and subclass

CCDC170 SPEF2 CFAP43 DNAH1 FHAD1 DNAH5 DNAH9

1.14e-061751367c01a15b2084da4a18f8ff3623f44eb9dfe499f10
ToppCellfacs-Trachea-nan-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDH26 SPEF2 CFAP43 ONECUT1 FHAD1 DNAH5 DNAH9

1.19e-061761367ed788a5969edfd1199828ca5b0dd34e7f29c4d30
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC170 DNAH3 SPEF2 CFAP43 DNAH1 OSCP1 DNAH9

1.28e-0617813673b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

OXR1 CAMK2B IGF2BP2 CEACAM16 PLD5 PLEC UNC5D

1.28e-061781367a0ab20c588e7d43d0320d4779d9ab95c1c86e297
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 DNAH5 DNAH9

1.48e-061821367fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMG1 VPS13C TRIP11 ZEB2 AKAP12 MACF1 GOLGA4

1.60e-0618413671154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 DNAH5 DNAH9

1.60e-061841367797b6a6d6f6aafae98f75ca8bffe8263f8d3ff9b
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 DNAH5 DNAH9

1.60e-06184136777d5b60a20b277f589b18f7a131142a7ef2dac17
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMG1 TCOF1 VPS13C TRIP11 ZEB2 AKAP12 MACF1

1.66e-0618513677adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

VPS13C PPFIA2 LAMA3 ZEB2 VCAN PLEC UNC5D

1.72e-06186136723b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellControl-Endothelial-Endothelial-Vein|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RIN3 TNFSF10 SPEF2 ZNF521 ABCB1 MMRN1 PTPRN2

1.72e-06186136792092f11ecce22c14f244e42c499af0822977e6f
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC170 SPEF2 CFAP43 DNAH1 FHAD1 DNAH5 DNAH9

1.78e-06187136704dba2ed09ee4180830bdf0191921696697ea234
ToppCellPND03|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLK SPEF2 PPP1R9A CFAP43 ACTR2 FHAD1 DNAH5

1.78e-061871367b3fcb36d853adfdea7172c5591de06f027e50af3
ToppCellP15-Epithelial-airway_epithelial_cell-club_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CCDC170 DNAH3 SPEF2 DNAH1 FHAD1 DNAH5 DNAH9

1.78e-061871367a70aaae32426e9ddb1cbfbd0e0db24ccc96b9f40
ToppCellfacs-Lung-EPCAM-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC170 SPEF2 CFAP43 DNAH1 FHAD1 DNAH5 DNAH9

1.78e-061871367805dafe22f835ece4dd091d8030d0a63b52a48dd
ToppCellmulticiliated|World / shred by cell class for bronchial biopsy

CCDC170 DNAH3 SPEF2 CFAP43 OSCP1 DNAH5 DNAH9

1.84e-0618813676833c1f0f265ef5448fa65033550ed7efc2f8d7b
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CCDC170 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.84e-06188136782c006f43c93f4a867953a446864f02b44536a23
ToppCellCiliated|World / Class top

CDH26 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.84e-061881367cc9178361360b5800f96516ed6a65089c144b1ce
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CCDC170 SPEF2 CFAP43 FHAD1 OSCP1 DNAH5 DNAH9

1.84e-061881367da59b5c0a4b11690a39a964c1a0a83e66aa0972b
ToppCellP15-Epithelial-airway_epithelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CCDC170 DNAH3 SPEF2 DNAH1 FHAD1 DNAH5 DNAH9

1.84e-061881367e3e71c0f2e374330620cb4d27638953ffa9f5298
ToppCellPND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 DNAH5 DNAH9

1.91e-061891367057d7a03fdbe779122b203619a6f947f49b84d28
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 DNAH5 DNAH9

1.91e-061891367b55de812043b670cbde810d7d42f45909b6d66ef
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC170 DNAH3 SPEF2 CFAP43 FHAD1 DNAH5 DNAH9

1.91e-06189136702c6128a9ab5818e0881dcadafdad5f08b9a67cf
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

BDP1 SLK AHCTF1 SMC5 TRIP11 SYNE2 MACF1 SUZ12 GOLGA4 GOLGB1

5.60e-12508710GAVISH_3CA_MALIGNANT_METAPROGRAM_4_CHROMATIN
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

BDP1 SMG1 SYNE1 SYNE2 MACF1 GOLGA4 GOLGB1

1.16e-0749877GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN
DrugClorgyline

MON2 BDP1 KLHL2 SLK VPS13C FAS TBC1D8B TRIP11 GOLGA4 GOLGB1

6.07e-0816813410ctd:D003010
DrugAC1L1I0J

KRT31 KRT33A KRT33B KRT34 FAS

7.13e-08191345CID000004371
DrugVistar

KRT31 KRT33A KRT33B KRT34 VCAN

2.13e-06361345CID000040896
DrugAC1Q6X9N

TNFSF10 KRT31 FAS ABCB1 ABCC2

4.68e-06421345CID000072205
Drughomocysteine thiolactone

KLHL2 KRT31 KRT33A KRT33B KRT34 KRT20 DNAH9

1.27e-051311347CID000107712
DrugNSC34533

KRT31 KRT33A KRT33B KRT34 KRT20

1.64e-05541345CID000003512
DrugIsoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Down 200; 16.4uM; MCF7; HT_HG-U133A

CEP162 KIAA0319L ZYX PPP3R1 HMGXB3 EEA1 PLEC IQCE

2.01e-0519413482824_DN
DrugCK17

MYH11 KRT31 KRT33B KRT34 KRT20

2.15e-05571345CID000128831
DrugIC261

DNAH3 GRIK2 DNAH1 PLEC DNAH5 DNAH9

2.23e-05961346CID000003674
DrugMeptazinol hydrochloride [59263-76-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A

TRIM25 GAS6 LAMA3 ZYX PPP3R1 MACF1 HMGXB3 PLEC

2.24e-0519713484774_DN
DrugBethanechol chloride [590-63-6]; Down 200; 20.4uM; HL60; HT_HG-U133A

MON2 RIN3 CEP162 KIAA0319L FAS HMGXB3 PLEC GOLGB1

2.24e-0519713482975_DN
Drug3 alpha,6 alpha-dihydroxy-5 beta-cholanoic acid

SYNE1 ABCB1 PLEC ABCC2

2.43e-05291344CID000006747
Drugenkephalin-Leu, Ala(2)-melphalan methyl ester-

ABCB1 ABCC2

3.44e-0521342ctd:C040240
Drugbenzoylmesaconine

ABCB1 ABCC2

3.44e-0521342ctd:C085283
Drugbenzoylaconine

ABCB1 ABCC2

3.44e-0521342ctd:C047307
Diseaseforced expiratory volume, response to bronchodilator

RIN3 OXR1 SYNE1 PPFIA2 SPEF2 IGF2BP2 FCER2 TXNRD3 PLEC DNAH5

3.34e-0544513210EFO_0004314, GO_0097366
Diseasediabetic retinopathy

SLK TRIB2 VPS13C KIAA0825 PTPRN2 OSCP1

3.49e-051361326EFO_0003770
DiseasePrimary Ciliary Dyskinesia

SPEF2 DNAH1 DNAH5 DNAH9

5.88e-05471324C4551720
DiseaseSphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0) measurement

APOE SYNE2

5.94e-0531322EFO_0022111
DiseaseCohen syndrome (implicated_via_orthology)

VPS13C VPS13B

5.94e-0531322DOID:0111590 (implicated_via_orthology)
DiseaseN-palmitoyl-sphinganine (d18:0/16:0) measurement

APOE SYNE2

5.94e-0531322EFO_0800428
Diseasechronic myeloid leukemia (is_implicated_in)

FAS ABCB1 ABCC2

1.10e-04211323DOID:8552 (is_implicated_in)
DiseaseSphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1) measurement

APOE SYNE2

1.18e-0441322EFO_0022112
DiseaseSphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1) measurement

APOE SYNE2

1.18e-0441322EFO_0022116
DiseaseAutosomal dominant Emery-Dreifuss muscular dystrophy

SYNE1 SYNE2

1.18e-0441322cv:CN293514
DiseaseIntellectual Disability

OXR1 CAMK2B SYNE1 GRIN2D AP4E1 MACF1 SUZ12 TBC1D23 ZBTB11

1.90e-044471329C3714756
DiseaseSphingomyelin (d18:1/20:0, d16:1/22:0) measurement

APOE SYNE2

1.97e-0451322EFO_0022109
DiseaseAutosomal Recessive Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

1.97e-0451322C1450051
DiseaseMuckle-Wells Syndrome

ZEB2 NLRC4

1.97e-0451322C0268390
Diseasecholestasis (is_marker_for)

APOE ABCC2

1.97e-0451322DOID:13580 (is_marker_for)
DiseaseAutosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)

SYNE1 SYNE2

1.97e-0451322C0410190
Diseasenuclear receptor-binding protein measurement

APOE PLEC

1.97e-0451322EFO_0801854
Diseaseglucose tolerance test

CAMK2B VPS13C IGF2BP2

2.37e-04271323EFO_0004307
DiseaseEmery-Dreifuss muscular dystrophy

SYNE1 SYNE2

2.94e-0461322cv:C0410189
Diseasestearoyl sphingomyelin (d18:1/18:0) measurement

APOE SYNE2

2.94e-0461322EFO_0800611
DiseaseMuscular Dystrophy, Emery-Dreifuss

SYNE1 SYNE2

2.94e-0461322C0410189
DiseasePostaxial polydactyly type A

KIAA0825 IQCE

2.94e-0461322C3887487
DiseaseMalignant neoplasm of breast

TNFSF10 SYNE1 GRIK2 GRIN2D ZEB2 AKAP12 ABCB1 SYNE2 MROH7 MACF1 DNAH9 MRPL9 VPS13B GOLGB1

3.34e-04107413214C0006142
DiseaseX-Linked Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

4.11e-0471322C0751337
Diseaseurate measurement, bone density

PPFIBP1 SYNE1 PPFIA2 AHCTF1 AKAP12 DNAH1 FSIP2 PTPRN2 ADGRE3 DNAH9

4.85e-0461913210EFO_0003923, EFO_0004531
DiseaseKartagener Syndrome

SPEF2 DNAH1 DNAH9

5.16e-04351323C0022521
DiseaseCiliary Dyskinesia, Primary, 1, With Or Without Situs Inversus

SPEF2 DNAH1 DNAH9

5.16e-04351323C4551906
DiseasePolynesian Bronchiectasis

SPEF2 DNAH1 DNAH9

5.16e-04351323C4317124
Diseasetriglyceride measurement, very low density lipoprotein cholesterol measurement

GAS6 APOE DNAH1 BUD23 SYNE2 MACF1

5.29e-042241326EFO_0004530, EFO_0008317
Diseasegallbladder neoplasm

ABCB1 KIAA0825

7.00e-0491322EFO_0004606
Diseasewaist circumference

TRIB2 PPP1R9A APOE FAS STX4 SYNE2 DNAH5 UNC5D

7.18e-044291328EFO_0004342
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

APOE ABCB1 HMGXB3 PLEC ABCC2 ARHGAP45

7.43e-042391326EFO_0010934
DiseaseCannabis Abuse

CAMK2B ABCB1

8.73e-04101322C0006868
DiseaseCannabis-Related Disorder

CAMK2B ABCB1

8.73e-04101322C0236735
DiseaseHashish Abuse

CAMK2B ABCB1

8.73e-04101322C0018614
Diseasecoronary artery calcification

BDP1 GRIK2 APOE ONECUT1 FSIP2 PTPRN2 PLD5 TBC1D23

9.76e-044501328EFO_0004723
Diseaseendometriosis

CCDC170 RIN3 SYNE1 GRIK2 GRIN2D VPS13B

9.77e-042521326EFO_0001065
Diseaseimmunoglobulin isotype switching measurement

RIN3 LAMA3 ARHGAP45

1.01e-03441323EFO_0010128
DiseaseColorectal Carcinoma

DNAH3 TCOF1 TNFSF10 SYNE1 ZEB2 AKAP12 ABCB1 PTPRN2 KRT20 ABCC2

1.26e-0370213210C0009402
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

SYNE1 SYNE2

1.27e-03121322DOID:11726 (implicated_via_orthology)
DiseaseAlzheimer disease, dementia, family history of Alzheimer’s disease

KCNH8 APOE ARHGAP45

1.31e-03481323EFO_0009268, MONDO_0001627, MONDO_0004975
Diseaseresponse to trauma exposure

TET1 PLD5 UNC5D

1.56e-03511323EFO_0008483
Diseaselean body mass

TRIM25 VPS13C PPFIA2 IGF2BP2 KIAA0825 VCAN PLEC

1.63e-033791327EFO_0004995
Diseasehealth literacy measurement

SMG1 FCHSD2 TLK1

1.74e-03531323EFO_0010104
Diseasenervous system disorder

TTPA ABCB1 ABCC2

1.74e-03531323C0027765
Diseasephosphatidylcholine measurement

CEP162 GRIK2 APOE SYNE2 MACF1 UNC5D

1.79e-032841326EFO_0010226
DiseaseDrug habituation

SLK SYNE1 GRIK2 TMPRSS7

1.80e-031151324C0013170
DiseaseDrug abuse

SLK SYNE1 GRIK2 TMPRSS7

1.80e-031151324C0013146
DiseasePrescription Drug Abuse

SLK SYNE1 GRIK2 TMPRSS7

1.80e-031151324C4316881
DiseaseSubstance-Related Disorders

SLK SYNE1 GRIK2 TMPRSS7

1.80e-031151324C0236969
DiseaseDrug Use Disorders

SLK SYNE1 GRIK2 TMPRSS7

1.80e-031151324C0013222
DiseaseDrug Dependence

SLK SYNE1 GRIK2 TMPRSS7

1.80e-031151324C1510472
DiseaseSubstance Dependence

SLK SYNE1 GRIK2 TMPRSS7

1.80e-031151324C0038580
DiseaseSubstance Use Disorders

SLK SYNE1 GRIK2 TMPRSS7

1.80e-031151324C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

SLK SYNE1 GRIK2 TMPRSS7

1.80e-031151324C0029231
DiseaseSubstance abuse problem

SLK SYNE1 GRIK2 TMPRSS7

1.86e-031161324C0740858
DiseaseSitus ambiguus

DNAH5 DNAH9

2.01e-03151322C0266642
Diseasetriglycerides in LDL measurement

GAS6 APOE SYNE2

2.04e-03561323EFO_0022320
Diseaselow density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

TNFSF10 APOE DNAH1 SYNE2 MACF1

2.10e-032001325EFO_0004611, EFO_0020945
DiseaseSchizophrenia

CAMK2B GRIK2 GRIN2D APOE FAS ACTR2 ABCB1 IGF2BP2 PPP3R1 TET1 HOMER1

2.10e-0388313211C0036341
Diseaseneurofilament light chain measurement

APOE PTPRN2 UNC5D

2.15e-03571323EFO_0009178
Diseasephosphatidylcholine 38:6 measurement

AHCTF1 DEPDC5

2.29e-03161322EFO_0010388
DiseaseCannabis Dependence

CAMK2B ABCB1

2.58e-03171322C0006870
Diseasecutaneous melanoma, hair color

PPFIBP2 AKAP12 SYNE2

2.73e-03621323EFO_0000389, EFO_0003924
Diseaseresponse to paliperidone, schizophrenia symptom severity measurement

OXR1 ICE1 SMC5 ADGRE3 OSCP1

2.93e-032161325EFO_0007925, EFO_0007927
DiseaseSeizures

ATP7A OXR1 APOE MACF1 ABCC2

3.04e-032181325C0036572
Diseaseprimary ciliary dyskinesia (implicated_via_orthology)

SPEF2 DNAH5

3.23e-03191322DOID:9562 (implicated_via_orthology)
Diseasecerebral microbleeds

APOE ABCB1

3.23e-03191322EFO_0010059
DiseaseHbA1c measurement

CAMK2B GAS6 APOE FCHSD2 IGF2BP2 TET1 MACF1 ARHGAP45 UNC5D

3.42e-036751329EFO_0004541
Diseasesphingomyelin 16:0 measurement

SPEF2 APOE

3.58e-03201322EFO_0010391
Diseaseend stage renal disease (implicated_via_orthology)

ABCB1 ABCC2

3.58e-03201322DOID:783 (implicated_via_orthology)
DiseaseNeutropenia

ABCB1 SMARCD2

3.94e-03211322C0027947
Diseaseestrogen-receptor negative breast cancer

CCDC170 RIN3 TNFSF10

4.01e-03711323EFO_1000650
Diseasetype 1 diabetes mellitus (is_marker_for)

TNFSF10 APOE FAS

4.17e-03721323DOID:9744 (is_marker_for)
DiseaseSplenomegaly

APOE FAS

4.33e-03221322C0038002

Protein segments in the cluster

PeptideGeneStartEntry
TQLQVAQSEEVILID

C2orf16

491

Q68DN1
KLEEVVVSSQDQQIV

CCDC185

246

Q8N715
ENSEQLELITTQATK

BUD23

166

O43709
KVLTVSNSQIETEIE

BDP1

1616

A6H8Y1
ISKQQAEQISILQTE

CFAP43

1636

Q8NDM7
LSEQVQEELLSSQVT

APOE

61

P02649
KQTQESVTQIEQIEV

VCAN

481

P13611
SVSKIQVQLEIQETS

CCDC7

836

Q96M83
VSEEVSKQLLQTVNV

AKAP12

1366

Q02952
VTVQGKTETLEVELQ

CEACAM16

406

Q2WEN9
ETQKRQQLSEDTLTI

C22orf31

191

O95567
QVDESQSIKNELTIQ

GKAP1

311

Q5VSY0
DTQLQQIVDKTIINA

PPP3R1

126

P63098
EVEVKQQLELSLQTL

ANKRD26

826

Q9UPS8
NIEQEQKLALETTVL

ACTR2

226

P61160
NTVVKDLQSTNLVEV

AP4E1

136

Q9UPM8
TTLSQIVKLVEEAQT

ATP7A

911

Q04656
ISELDTKVSQLQEQV

CCDC27

526

Q2M243
VENVTTLQKSQDLLE

MROH7

436

Q68CQ1
EEIQTLTSKLQELQE

IQCE

451

Q6IPM2
IQKALESISSDQQVI

PUM2

816

Q8TB72
NVQNVTTEDVEKATV

PTPRN2

561

Q92932
IENFRTVVSLTQEQK

ABCB1

901

P08183
DLQKETISVDQTVTQ

DEPDC5

61

O75140
IQEVIRQSDQTIKSA

ARHGAP45

491

Q92619
TLNIVTVQKEVIDTN

LAMA3

2251

Q16787
TEELNKQVVSSSEQL

KRT31

251

Q15323
LTDAIKDTVQQIVSV

KIAA0825

906

Q8IV33
QESLQSVKNTTEQEI

NLRC4

531

Q9NPP4
LVLQVSVLTDQVEAQ

PPFIBP1

116

Q86W92
LETNQKEQIESLTEV

GOLGA4

1021

Q13439
LETVAKTLQETIQAQ

IHO1

171

Q8IYA8
QSQSSVNVIVKEEIN

KIAA0319L

676

Q8IZA0
ESTRQIIQKVNESVV

MMRN1

421

Q13201
QESIQKILAVQEESS

CCDC178

831

Q5BJE1
EKVTSEELNIIIQNV

FSIP2

501

Q5CZC0
LILSNVSEETVTIEQ

HMGXB3

721

Q12766
AELQLATTVSQQELV

ITGAE

831

P38570
NQIETVLSTRIQLEE

KRT222

21

Q8N1A0
QKSQSTQISQELEEL

FCER2

81

P06734
EINTKEVAQRITTEL

ONECUT1

291

Q9UBC0
KVEATNQIIAIEQSQ

MYRFL

301

Q96LU7
TEELNKQVVSSSEQL

KRT33A

251

O76009
LQLVESEKSEIQLNV

GOLGA6L22

181

H0YM25
QSFLQSQVVIEESIL

GBP7

461

Q8N8V2
AVDLETDNLIQTTIQ

ABCC2

1466

Q92887
TVNELQNLTSAEVIV

IGF2BP2

531

Q9Y6M1
NIDVEVVQLISNEIL

MON2

1521

Q7Z3U7
VQVLELETQLAKATV

MMEL1

306

Q495T6
AVLQQQVTVNTEELK

KRT20

266

P35900
QVTVNTEELKGTEVQ

KRT20

271

P35900
LQVTSQILQKNTDVV

HDGFL2

506

Q7Z4V5
KTELNQTIQELEETL

HOMER1

246

Q86YM7
LILQVSVLTDQVEAQ

PPFIBP2

121

Q8ND30
VLQEQLATTKQLQEE

MACF1

4036

Q9UPN3
EVLIQITTQLKLEQT

MEI1

116

Q5TIA1
VQTVNQAEVESLTVK

OXR1

371

Q8N573
DVVSKLIQENVVSVN

DNAH1

1501

Q9P2D7
QELNKITTQLDQVTA

EEA1

681

Q15075
LSQEVVVNLLQETKQ

EXOC5

411

O00471
IDVNINSQEEVVKLT

EPB41L5

526

Q9HCM4
TDQQLIEKITQVTED

FHAD1

516

B1AJZ9
VTSEVINVLINKDQN

ICE1

1401

Q9Y2F5
VQETVTIDNEKNTAI

GKN2

36

Q86XP6
QISVDKNVSEIIATI

IDNK

166

Q5T6J7
VLTQEQSIKAELETL

CC2D2A

366

Q9P2K1
QQALELVVQEVSSVL

C2CD2

106

Q9Y426
VAKDVQVQIITTEAL

DNAH3

1376

Q8TD57
LNGEDTTIQETVKVN

GAS6

451

Q14393
KEQETTGILQTQLQE

CEP250

961

Q9BV73
QVNELQSKQESLVVS

CEP162

1266

Q5TB80
LLQVSIIDSVQQETD

CDH26

21

Q8IXH8
VSQLEAQISELVEQL

CCDC170

366

Q8IYT3
NQESVEIINDLKVST

AHCTF1

1881

Q8WYP5
GETVLVENLEITKQT

DNAH9

3636

Q9NYC9
VDQLTKIQTELQETV

FCHSD2

131

O94868
INAVATLEKVIEIQS

HDAC5

1041

Q9UQL6
ILNTENTQVSSIIEK

GRIK2

281

Q13002
IDEITDINNTTQLAI

GTF2IRD2

551

Q86UP8
IDEITDINNTTQLAI

GTF2IRD2B

551

Q6EKJ0
TQKLEISAETEVQIN

DNAH5

3796

Q8TE73
ETSQIVELQELLEKQ

PPFIA2

266

O75334
DKITVTRQLSVEVQD

RIN3

841

Q8TB24
ASQKDVIEQLQTTQT

TAF5L

131

O75529
QEIIKTTEQLIEAVN

CAMK2B

536

Q13554
QILSIDTLVQEAIQA

SPEF2

586

Q9C093
VKVTINDLNENSVTL

TRMT1L

301

Q7Z2T5
IKDTILQTVDLVSQE

SLK

491

Q9H2G2
LTSQNIEIKLVSDVT

PLD5

176

Q8N7P1
IVSSIQEQITKANEE

SYNE1

2481

Q8NF91
TTAKDIQQTEQTIEQ

SYNE1

4106

Q8NF91
SLEIFTKLEEIQQQI

SYNE2

1776

Q8WXH0
EQLLESITESENKIQ

SYNE2

5166

Q8WXH0
VTEEKVSITQLQAQV

TMEM132E

676

Q6IEE7
VQASVVKVLTELLEQ

TCOF1

1311

Q13428
VQSLITNVESQLAEI

KRT34

356

O76011
LSQIETSIATVQEKL

SMG1

3236

Q96Q15
QSEVFVSNILKDTQV

STX4

181

Q12846
TILQQVDETLRQLTE

OSCP1

141

Q8WVF1
NFSVQETQTLLKEIT

MSANTD4

11

Q8NCY6
STTNQQEIASLDVKI

SMARCD2

426

Q92925
TQIEEDVATQLTQLA

TET1

1071

Q8NFU7
KIQNDSVAIETQAIT

ADGRE3

186

Q9BY15
QSEISEILNKSIIEV

CCDC110

81

Q8TBZ0
QSIELEEGSIVLKTQ

CCDC15

396

Q0P6D6
EEQLSILKVVSSVLQ

MYH11

341

P35749
KENLELILTQSVENV

MRPL9

91

Q9BYD2
QDILQENTILKATEV

TLK1

681

Q9UKI8
SVDLITKNNQTELET

ZBTB11

411

O95625
LEETTKQNVLRVVSQ

TBC1D8B

776

Q0IIM8
SLVLQQAEVELIDQT

TMPRSS7

746

Q7RTY8
ELRKTVTTVETQNLE

FAS

36

P25445
SNINQITEIILGETK

TRIB2

111

Q92519
ENEQNSVTLEVLLVK

SUZ12

176

Q15022
TINQTVEELNTNKES

THAP5

256

Q7Z6K1
SEIQTLKEEIEQSLT

TRIM25

286

Q14258
VQKEEVELQTLLTNS

ZNF521

851

Q96K83
IILVNAKEVILTQES

TBC1D23

236

Q9NUY8
LIEEQNVISVITETL

UBR1

431

Q8IWV7
QESNVQLKLTIVDAV

SEPTIN8

91

Q92599
LTQSKVSEEIQKEIQ

VPS13C

416

Q709C8
EEQVIKSQSTILQEV

PKHD1L1

496

Q86WI1
KSQSTILQEVQVITL

PKHD1L1

501

Q86WI1
TQEKVTLVQTLEIQR

PLEC

2561

Q15149
SLITSELIVQEVETQ

TTPA

136

P49638
QILQVQTSILESERE

UNC5D

816

Q6UXZ4
AQKVTQAQTEISVVE

TRAV19

21

A0A0A6YYK7
VQVESLQEQLNVVSK

TRIP11

1636

Q15643
QIIQIEDKTTIINNT

VPS13B

3101

Q7Z7G8
LTLKEVEELEQLTQQ

ZYX

351

Q15942
RVQEVLSEITNQKTV

TXNRD3

106

Q86VQ6
NLSEVQKVLQIVDNT

ZEB2

456

O60315
SEETISTVQEKQQNI

TNFSF10

96

P50591
QKVDLILQNTTVISE

SMC5

766

Q8IY18
TISEQQAELILQSID

SLC25A24

121

Q6NUK1
TLQQTIEEKDQQVTE

GOLGB1

891

Q14789
KEVQQLQENLDSTVT

GOLGB1

2171

Q14789
TAEIQVTEENVQVLL

KLHL2

116

O95198
QINKLNSEVTTLTQE

KCNH8

866

Q96L42
TEELNKQVVSSSEQL

KRT33B

251

Q14525
VSEVAQLISQTLEQE

PPP1R9A

596

Q9ULJ8
SSTEQQLQVIFEVLE

GRIN2D

166

O15399