Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Mediator_Med25	PTOV1 MED25	1.38e-05	2	70	2	IPR021394
Domain	Med25	PTOV1 MED25	1.38e-05	2	70	2	PF11232
Domain	VGCC_alpha2	CACNA2D2 CACNA2D3	8.27e-05	4	70	2	PF08473
Domain	VDCC_a2/dsu	CACNA2D2 CACNA2D3	8.27e-05	4	70	2	IPR013680
Domain	P5-ATPase	ATP13A4 ATP13A5	8.27e-05	4	70	2	PF12409
Domain	VWA_N	CACNA2D2 CACNA2D3	1.37e-04	5	70	2	IPR013608
Domain	VWA_N	CACNA2D2 CACNA2D3	1.37e-04	5	70	2	PF08399
Domain	P-type_TPase_V	ATP13A4 ATP13A5	1.37e-04	5	70	2	IPR006544
Domain	ATPase_P-typ_transduc_dom_A	ATP13A4 TMEM94 ATP13A5	3.58e-04	37	70	3	IPR008250
Domain	E1-E2_ATPase	ATP13A4 TMEM94 ATP13A5	3.58e-04	37	70	3	PF00122
Domain	VWF_A	CACNA2D2 MED25 ITGA2 CACNA2D3	5.21e-04	99	70	4	IPR002035
Domain	VWA	CACNA2D2 ITGA2 CACNA2D3	1.21e-03	56	70	3	PF00092
Domain	Cation_ATPase_N	ATP13A4 ATP13A5	2.04e-03	18	70	2	PF00690
Domain	Cation_ATPase_N	ATP13A4 ATP13A5	2.04e-03	18	70	2	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP13A4 ATP13A5	2.27e-03	19	70	2	IPR004014
Domain	UDPGT	UGT1A4 UGT1A5	2.78e-03	21	70	2	PF00201
Domain	UDPGT	UGT1A4 UGT1A5	2.78e-03	21	70	2	PS00375
Domain	UDP_glucos_trans	UGT1A4 UGT1A5	2.78e-03	21	70	2	IPR002213
Domain	VWFA	CACNA2D2 ITGA2 CACNA2D3	3.61e-03	82	70	3	PS50234
Domain	VWA	CACNA2D2 ITGA2 CACNA2D3	3.87e-03	84	70	3	SM00327
Domain	HormR	SCTR GCGR	3.93e-03	25	70	2	SM00008
Domain	HRM	SCTR GCGR	4.91e-03	28	70	2	PF02793
Domain	Alkaline_phosphatase_core	PIGO ALPG	6.00e-03	31	70	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	PIGO ALPG	6.00e-03	31	70	2	IPR017849
Domain	-	PIGO ALPG	6.00e-03	31	70	2	3.40.720.10
Domain	-	ATP13A4 ATP13A5	6.39e-03	32	70	2	3.40.1110.10
Domain	-	ATP13A4 ATP13A5	6.39e-03	32	70	2	2.70.150.10
Domain	LRR	LRRC10 LRRC69 NLRC5 TLR6	6.86e-03	201	70	4	PS51450
Domain	GPCR_2_secretin-like_CS	SCTR GCGR	7.19e-03	34	70	2	IPR017983
Domain	ATPase_P-typ_cyto_domN	ATP13A4 ATP13A5	7.61e-03	35	70	2	IPR023299
Domain	P_typ_ATPase	ATP13A4 ATP13A5	8.03e-03	36	70	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP13A4 ATP13A5	8.03e-03	36	70	2	IPR018303
Domain	ATPASE_E1_E2	ATP13A4 ATP13A5	8.03e-03	36	70	2	PS00154
Domain	LRR_1	LRRC10 LRRC69 NLRC5 TLR6	9.22e-03	219	70	4	PF00560
Domain	G_PROTEIN_RECEP_F2_1	SCTR GCGR	9.85e-03	40	70	2	PS00649
Domain	GPCR_2_extracellular_dom	SCTR GCGR	9.85e-03	40	70	2	IPR001879
Domain	G_PROTEIN_RECEP_F2_3	SCTR GCGR	9.85e-03	40	70	2	PS50227
Pubmed	PTOV1 antagonizes MED25 in RAR transcriptional activation.	PTOV1 MED25	4.59e-06	2	75	2	21110951
Pubmed	Characterization of a novel cation transporter ATPase gene (ATP13A4) interrupted by 3q25-q29 inversion in an individual with language delay.	ATP13A4 ATP13A5	4.59e-06	2	75	2	15925480
Pubmed	Association of BglII Polymorphism in ITGA2 and (894G/T and -786T/C) Polymorphisms in eNOS Gene With Stroke Susceptibility in Tunisian Patients α2 Gene Polymorphism in α2β1 Integrin and eNOS Gene Variants and Stroke.	ITGA2 NOS3	4.59e-06	2	75	2	33297767
Pubmed	Presynaptic α2δ subunits are key organizers of glutamatergic synapses.	CACNA2D2 CACNA2D3	1.37e-05	3	75	2	33782113
Pubmed	Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo.	THPO IL2RG	1.37e-05	3	75	2	21262827
Pubmed	The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function.	CACNA2D2 CACNA2D3	1.37e-05	3	75	2	20080692
Pubmed	The trafficking of prosaposin (SGP-1) and GM2AP to the lysosomes of TM4 Sertoli cells is mediated by sortilin and monomeric adaptor proteins.	SORT1 GM2A	1.37e-05	3	75	2	15236333
Pubmed	Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.	SLC26A8 THPO GCGR ITGA2 NOS3	2.01e-05	152	75	5	19578796
Pubmed	EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes.	ITGA2 NOS3	2.75e-05	4	75	2	18806884
Pubmed	Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population.	UGT1A4 UGT1A5	2.75e-05	4	75	2	18223459
Pubmed	Role of alpha2/delta subunit in the development of morphine-induced rewarding effect and behavioral sensitization.	CACNA2D2 CACNA2D3	2.75e-05	4	75	2	19596051
Pubmed	Predictive role of polymorphisms in interleukin-5 receptor alpha-subunit, lipoprotein lipase, integrin A2 and nitric oxide synthase genes on ischemic stroke in type 2 diabetes--an 8-year prospective cohort analysis of 1327 Chinese patients.	ITGA2 NOS3	2.75e-05	4	75	2	21193198
Pubmed	Engineering an inhibitor-resistant human CSF1R variant for microglia replacement.	THPO IL2RG	4.57e-05	5	75	2	36584406
Pubmed	Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity.	THPO IL2RG	4.57e-05	5	75	2	30352428
Pubmed	Parkinson disease related ATP13A2 evolved early in animal evolution.	ATP13A4 ATP13A5	4.57e-05	5	75	2	29505581
Pubmed	Characterization of the P5 subfamily of P-type transport ATPases in mice.	ATP13A4 ATP13A5	4.57e-05	5	75	2	15381061
Pubmed	Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations.	THPO IL2RG	4.57e-05	5	75	2	25561180
Pubmed	Abnormal high-density lipoprotein induces endothelial dysfunction via activation of Toll-like receptor-2.	TLR6 NOS3	4.57e-05	5	75	2	23477738
Pubmed	Development and function of human innate immune cells in a humanized mouse model.	THPO IL2RG	6.84e-05	6	75	2	24633240
Pubmed	Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.	THPO IL2RG	6.84e-05	6	75	2	30504915
Pubmed	Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.	THPO IL2RG	6.84e-05	6	75	2	31375314
Pubmed	iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.	THPO IL2RG	6.84e-05	6	75	2	28426964
Pubmed	The fate and lifespan of human monocyte subsets in steady state and systemic inflammation.	THPO IL2RG	6.84e-05	6	75	2	28606987
Pubmed	inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice.	THPO IL2RG	6.84e-05	6	75	2	27581357
Pubmed	Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.	CACNA2D2 CACNA2D3	6.84e-05	6	75	2	30683685
Pubmed	Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.	GCGR IL2RG	6.84e-05	6	75	2	28591638
Pubmed	A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies.	THPO IL2RG	6.84e-05	6	75	2	30664659
Pubmed	Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37.	UGT1A4 UGT1A5	9.57e-05	7	75	2	8467709
Pubmed	Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice.	THPO IL2RG	9.57e-05	7	75	2	27723723
Pubmed	Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.	THPO IL2RG	9.57e-05	7	75	2	33097708
Pubmed	Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis.	THPO IL2RG	1.27e-04	8	75	2	37957324
Pubmed	A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.	UGT1A4 UGT1A5	1.64e-04	9	75	2	22511988
Pubmed	A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.	UGT1A4 UGT1A5	1.64e-04	9	75	2	1339448
Pubmed	Intracellular bacterial infection-induced IFN-gamma is critically but not solely dependent on Toll-like receptor 4-myeloid differentiation factor 88-IFN-alpha beta-STAT1 signaling.	TLR6 IL2RG	1.64e-04	9	75	2	15128825
Pubmed	Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.	UGT1A4 UGT1A5	2.04e-04	10	75	2	23642732
Pubmed	UDP-glucuronosyltransferases.	UGT1A4 UGT1A5	2.04e-04	10	75	2	11465080
Pubmed	The IL-6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B-cell lymphoma.	THPO IL2RG	2.04e-04	10	75	2	31515941
Pubmed	A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.	UGT1A4 UGT1A5	2.04e-04	10	75	2	23371916
Pubmed	A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.	UGT1A4 UGT1A5	2.04e-04	10	75	2	22558097
Pubmed	Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms.	THPO IL2RG	2.99e-04	12	75	2	37550517
Pubmed	The genetics of primary haemorrhagic stroke, subarachnoid haemorrhage and ruptured intracranial aneurysms in adults.	ITGA2 NOS3	2.99e-04	12	75	2	19008959
Pubmed	Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.	UGT1A4 UGT1A5	2.99e-04	12	75	2	19419973
Pubmed	Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.	UGT1A4 UGT1A5	2.99e-04	12	75	2	11434514
Pubmed	UGT1A1 is a major locus influencing bilirubin levels in African Americans.	UGT1A4 UGT1A5	3.52e-04	13	75	2	22085899
Pubmed	Genome-wide analysis of hepatic lipid content in extreme obesity.	UGT1A4 UGT1A5	3.52e-04	13	75	2	25246029
Pubmed	Candidate gene polymorphisms for ischemic stroke.	TMCO6 ITGA2 NOS3	3.65e-04	64	75	3	19729601
Pubmed	Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.	UGT1A4 UGT1A5	4.11e-04	14	75	2	21646302
Pubmed	Human UDP-glucuronosyltransferases: metabolism, expression, and disease.	UGT1A4 UGT1A5	4.11e-04	14	75	2	10836148
Pubmed	MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation.	PTOV1 MED25	4.11e-04	14	75	2	17641689
Pubmed	Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.	UGT1A4 UGT1A5	4.11e-04	14	75	2	14672974
Pubmed	Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22.	THPO IL2RG	4.11e-04	14	75	2	36630911
Pubmed	The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.	UGT1A4 UGT1A5	4.11e-04	14	75	2	9295054
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA2D2 CACNA2D3	4.73e-04	15	75	2	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA2D2 CACNA2D3	4.73e-04	15	75	2	24453333
Pubmed	Genome-wide association meta-analysis for total serum bilirubin levels.	UGT1A4 UGT1A5	5.40e-04	16	75	2	19414484
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	SORT1 PTOV1 ITGA2 NOTCH3 RAVER1	5.40e-04	307	75	5	37499664
Pubmed	Genome-wide association of serum bilirubin levels in Korean population.	UGT1A4 UGT1A5	6.11e-04	17	75	2	20639394
Pubmed	A genome-wide assessment of variability in human serum metabolism.	UGT1A4 UGT1A5	7.66e-04	19	75	2	23281178
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	PTOV1 ADORA1 TMEM94 RHBDD2 MGLL TSPAN33 SLC45A4	7.69e-04	697	75	7	28298427
Pubmed	A systematic meta-analysis of genetic association studies for diabetic retinopathy.	ITGA2 NOS3	8.50e-04	20	75	2	19587357
Pubmed	Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.	ADORA1 SCTR GCGR CXCL5	9.38e-04	200	75	4	18240029
Pubmed	Interaction network of human early embryonic transcription factors.	SORT1 HIVEP1 TLE5 MGA DUXB	9.85e-04	351	75	5	38297188
Pubmed	Polymorphisms in innate immunity genes and risk of childhood leukemia.	TMCO6 TLR6 NOS3 RAVER1	1.05e-03	206	75	4	20438785
Pubmed	Risk of meningioma and common variation in genes related to innate immunity.	TMCO6 TLR6 NOS3 RAVER1	1.06e-03	207	75	4	20406964
Pubmed	Common variation in genes related to innate immunity and risk of adult glioma.	TMCO6 TLR6 NOS3 RAVER1	1.08e-03	208	75	4	19423540
Pubmed	Charcot-Marie-Tooth Neuropathy Type 2 – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	MED25 DHTKD1	1.13e-03	23	75	2	20301462
Pubmed	Discovery and refinement of loci associated with lipid levels.	SORT1 UGT1A4 NYNRIN UGT1A5	1.14e-03	211	75	4	24097068
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	SORT1 GM2A MGA SLC4A11	1.16e-03	212	75	4	19521566
Pubmed	Genetic determinants influencing human serum metabolome among African Americans.	UGT1A4 UGT1A5	1.23e-03	24	75	2	24625756
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	CAND2 HECTD4 NPHP4	1.42e-03	102	75	3	9734811
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	HIVEP1 MIS12 RAVER1	2.05e-03	116	75	3	30804394
Cytoband	2q37	UGT1A4 UGT1A5 ALPG	1.82e-05	31	75	3	2q37
Cytoband	Ensembl 112 genes in cytogenetic band chr6p21	SLC26A8 PI16 ARMC12 MSH5 VARS2	1.42e-03	503	75	5	chr6p21
GeneFamily	Parkinson disease associated genes\|ATPase orphan transporters	ATP13A4 ATP13A5	7.76e-05	5	51	2	1213
GeneFamily	Glucagon receptor family	SCTR GCGR	1.16e-04	6	51	2	269
GeneFamily	Calcium voltage-gated channel subunits	CACNA2D2 CACNA2D3	2.43e-03	26	51	2	253
GeneFamily	UDP glucuronosyltransferases	UGT1A4 UGT1A5	3.67e-03	32	51	2	363
GeneFamily	Olfactory receptors, family 5	OR5B2 OR5B17 OR5B21	3.88e-03	112	51	3	152
Disease	Kufor-Rakeb syndrome (implicated_via_orthology)	ATP13A4 ATP13A5	3.32e-05	4	70	2	DOID:0060556 (implicated_via_orthology)
Disease	juvenile-onset Parkinson's disease (implicated_via_orthology)	ATP13A4 ATP13A5	3.32e-05	4	70	2	DOID:0060893 (implicated_via_orthology)
Disease	X-11793--oxidized bilirubin measurement	UGT1A4 UGT1A5	1.54e-04	8	70	2	EFO_0021260
Disease	Succinimide measurement	UGT1A4 UGT1A5	1.54e-04	8	70	2	EFO_0022118
Disease	X-11530 measurement	UGT1A4 UGT1A5	1.54e-04	8	70	2	EFO_0021249
Disease	sulfate of piperine metabolite C16H19NO3 (2) measurement	UGT1A4 UGT1A5	1.54e-04	8	70	2	EFO_0801034
Disease	cholelithiasis, bilirubin measurement	UGT1A4 UGT1A5	1.54e-04	8	70	2	EFO_0004570, EFO_0004799
Disease	X-11522 measurement	UGT1A4 UGT1A5	1.54e-04	8	70	2	EFO_0800696
Disease	X-10458 measurement	UGT1A4 UGT1A5	1.54e-04	8	70	2	EFO_0800692
Disease	X-24849 measurement	UGT1A4 UGT1A5	1.54e-04	8	70	2	EFO_0800909
Disease	membrane-associated progesterone receptor component 1 measurement	UGT1A4 UGT1A5	1.54e-04	8	70	2	EFO_0802740
Disease	X-16946 measurement	UGT1A4 UGT1A5	1.54e-04	8	70	2	EFO_0800766
Disease	X-11442 measurement	UGT1A4 UGT1A5	1.98e-04	9	70	2	EFO_0021236
Disease	X-11441 measurement	UGT1A4 UGT1A5	1.98e-04	9	70	2	EFO_0021235
Disease	circulating cell free DNA measurement	UGT1A4 UGT1A5	1.98e-04	9	70	2	EFO_0004739
Disease	sulfate of piperine metabolite C18H21NO3 (3) measurement	UGT1A4 UGT1A5	1.98e-04	9	70	2	EFO_0801037
Disease	testis-specific chromodomain protein Y 1 measurement	UGT1A4 UGT1A5	1.98e-04	9	70	2	EFO_0802127
Disease	sulfate of piperine metabolite C18H21NO3 (1) measurement	UGT1A4 UGT1A5	1.98e-04	9	70	2	EFO_0801036
Disease	X-11880 measurement	UGT1A4 UGT1A5	1.98e-04	9	70	2	EFO_0800698
Disease	bilirubin measurement, response to xenobiotic stimulus	UGT1A4 UGT1A5	1.98e-04	9	70	2	EFO_0004570, GO_0009410
Disease	protein-tyrosine kinase 6 measurement	UGT1A4 UGT1A5	1.98e-04	9	70	2	EFO_0020691
Disease	X-21448 measurement	UGT1A4 UGT1A5	2.47e-04	10	70	2	EFO_0800816
Disease	UDP-glucuronosyltransferase 1-6 measurement	UGT1A4 UGT1A5	2.47e-04	10	70	2	EFO_0802185
Disease	X-23974 measurement	UGT1A4 UGT1A5	2.47e-04	10	70	2	EFO_0800867
Disease	bilirubin measurement, response to tenofovir	UGT1A4 UGT1A5	2.47e-04	10	70	2	EFO_0004570, EFO_0009279
Disease	X-21796 measurement	UGT1A4 UGT1A5	3.01e-04	11	70	2	EFO_0800825
Disease	pregnenetriol sulfate measurement	UGT1A4 UGT1A5	3.01e-04	11	70	2	EFO_0800586
Disease	plasma N-desmethylclozapine measurement	UGT1A4 UGT1A5	3.01e-04	11	70	2	EFO_0600039
Disease	insomnia, bilirubin measurement	UGT1A4 UGT1A5	3.01e-04	11	70	2	EFO_0004570, EFO_0004698
Disease	histidine betaine (hercynine) measurement	UGT1A4 UGT1A5	3.01e-04	11	70	2	EFO_0800972
Disease	aldosterone measurement	UGT1A4 UGT1A5	3.01e-04	11	70	2	EFO_0010219
Disease	biliverdin measurement	UGT1A4 UGT1A5	3.61e-04	12	70	2	EFO_0021033
Disease	p-cresol glucuronide measurement	UGT1A4 UGT1A5	3.61e-04	12	70	2	EFO_0800079
Disease	retinol dehydrogenase 16 measurement	UGT1A4 UGT1A5	4.25e-04	13	70	2	EFO_0802007
Disease	pregnenetriol disulfate measurement	UGT1A4 UGT1A5	4.25e-04	13	70	2	EFO_0800587
Disease	neuronal ceroid lipofuscinosis (implicated_via_orthology)	ATP13A4 ATP13A5	4.96e-04	14	70	2	DOID:14503 (implicated_via_orthology)
Disease	Coronary Arteriosclerosis	SORT1 HECTD4 NOS3	5.03e-04	65	70	3	C0010054
Disease	Coronary Artery Disease	SORT1 HECTD4 NOS3	5.03e-04	65	70	3	C1956346
Disease	X-21441 measurement	UGT1A4 UGT1A5	7.37e-04	17	70	2	EFO_0800814
Disease	low density lipoprotein cholesterol measurement, body fat percentage	UGT1A4 UGT1A5	7.37e-04	17	70	2	EFO_0004611, EFO_0007800
Disease	angiopoietin-related protein 1 measurement	UGT1A4 UGT1A5	8.28e-04	18	70	2	EFO_0801382
Disease	diet measurement, body mass index	ATP13A4 ATP13A5	1.03e-03	20	70	2	EFO_0004340, EFO_0008111
Disease	tissue factor measurement	UGT1A4 UGT1A5	1.13e-03	21	70	2	EFO_0010623
Disease	myeloperoxidase (MPO)-DNA complex measurement	ATP13A4 ATP13A5	1.24e-03	22	70	2	EFO_0011039
Disease	Ischemia	ADORA1 NOS3	2.02e-03	28	70	2	C0022116
Disease	stimulant use measurement	ATP13A4 HIVEP1	2.02e-03	28	70	2	EFO_0600076
Disease	xanthurenate measurement	UGT1A4 UGT1A5	2.16e-03	29	70	2	EFO_0010551
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	ATP13A4 ATP13A5	2.31e-03	30	70	2	DOID:332 (implicated_via_orthology)
Disease	response to dolutegravir	UGT1A4 UGT1A5	2.31e-03	30	70	2	EFO_0600017

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLPLLLLLVATTGPV	PI16	11	Q6UXB8
GQLLSPPLLLSIFLN	ATP13A5	966	Q4VNC0
PLLLLLPQLGIGNAS	C2orf69	11	Q8N8R5
FPPSLGVLVSLQLLL	CACNA2D2	1116	Q9NY47
LVIPLAILINIGPQT	ADORA1	61	P30542
LISPPLLLSVIFNIL	ATP13A4	966	Q4VNC1
PLAPLLALLNNIIEI	ANO4	731	Q32M45
RLNLLTGLLQFPPEL	DHTKD1	226	Q96HY7
LFLNLPLVIGTIPLH	ARRDC3	301	Q96B67
LHIAGLRLLNNLPLP	ARMC12	166	Q5T9G4
NLGPSASLQLLLNPL	RAVER1	336	Q8IY67
NNLLLLQQISLPELP	PZP	1301	P20742
LPGLKTLVLQNNLIP	LRRC69	36	Q6ZNQ3
NQLLLPLLQGPDITL	ANAPC5	61	Q9UJX4
ILLGLTDDPNLQIPL	OR5B21	11	A6NL26
GLTQRPELQLPLFLL	OR8D2	16	Q9GZM6
LDLPGNILIIPQATL	DTD2	81	Q96FN9
LVEPTLPGLFLLQQL	KIAA0100	261	Q14667
LIPLQSGSFALLQLP	MGA	1936	Q8IWI9
VLNLVLPNLSLGPID	MGLL	166	Q99685
LPLLTLSQPLLLGIA	NUDT22	196	Q9BRQ3
RPLSQLALPQVLGLI	JOSD2	91	Q8TAC2
LALPQVLGLILNLPS	JOSD2	96	Q8TAC2
ILLGLTSVPELQIPL	OR5B2	11	Q96R09
LLLLLLLACQPQVPS	GCGR	11	P47871
VPLLPLLVAGAVLLL	NOTCH3	1641	Q9UM47
QLIPQQLLTTLGPLF	MED25	451	Q71SY5
SLPPELGQLQNLQIL	LRRC10	66	Q5BKY1
PVQPLSLLLALALRN	AP5B1	181	Q2VPB7
LQLLSNQLLAPPLPD	HECTD4	2481	Q9Y4D8
LPLLLVLALSQGILN	ITGA2	11	P17301
LLLQVLLQEPNPGIE	ADAMTSL5	291	Q6ZMM2
LDCLPQLPQLSLLQL	NLRC5	1156	Q86WI3
LLPENLLVSGLQQIP	NPHP4	201	O75161
LLVSGLQQIPGLLPA	NPHP4	206	O75161
VALPAPLLLTQLPLL	NOS3	921	P29474
LIPQQLLTTLVPLFR	PTOV1	306	Q86YD1
PRPNPSQLLLLLALL	PRSS41	301	Q7RTY9
VVPALLPLLAGTLLL	ALPG	511	P10696
LPLILKNNGVLPAQL	HYDIN	3506	Q4G0P3
PSLQAQTVLLLLPLL	CACNA2D3	1071	Q8IZS8
LQLPQLPLAALQALG	F8A1;	171	P23610
QPLIIPNHLLTLPIL	DUXB	251	A0A1W2PPF3
LLFLQLPLLGVGLNT	IL2RG	11	P31785
ILINLLLKQPLIPGS	ATRIP	311	Q8WXE1
QALGILLIPPQAQEL	FAM186A	1501	A6NE01
LVAVSPLQLDLQPIL	CAND2	636	O75155
LLVLLLLLTQPGPIA	CXCL5	21	P42830
GDLLQLPPAVQELLL	NYNRIN	176	Q9P2P1
ILLGLTNAPELQVPL	OR5B17	11	Q8NGF7
LLLPELSGPLAVLLQ	FAM174A	21	Q8TBP5
SLVQLQLLPQGPLVQ	MSH5	711	O43196
QAPLLIALGLLLAAP	GM2A	6	P17900
LQGLVDPQIQLPLLA	VARS2	986	Q5ST30
SVLVGLSLLLLPVPL	SLC4A11	746	Q8NBS3
LLLLQLLPPSTLSQD	SORT1	21	Q99523
LTLSLLARQLIPPLN	SLC26A8	111	Q96RN1
LQLQLPSALTLLPPS	PRDM8	601	Q9NQV8
VLLSQLPSLLGLSLP	SLC26A10	161	Q8NG04
LPLLLLPQQLLQLVQ	RNASE9	11	P60153
FLLLPPGQVSLQQTL	C11orf42	136	Q8N5U0
QRICLPPNLALVLLG	NDUFV1-DT	211	Q8NBR9
QLSQLQALALPLTPL	TLE5	131	Q08117
ALVTPILLQIGLPEQ	SLC45A4	71	Q5BKX6
LLPILVPFILLGDIQ	WFDC6	6	Q9BQY6
LAIPQLVGILLSQIL	TSPAN33	246	Q86UF1
FLQLILRIPSNILLP	MIS12	86	Q9H081
QLQVNGVLPILPLLF	TMEM94	316	Q12767
LFLLQQPLAPSGLTL	RHBDD2	36	Q6NTF9
SPPLQQLLLPVLLAC	SCTR	6	P47872
QVPLPQLATGLLLLL	UGT1A5	6	P35504
LDLIEPLLQLLPVSN	TMCO6	381	Q96DC7
GFSPLQPGLLLLIIL	TMEM86B	116	Q8N661
LILILLEPIPQNSIP	TLR6	731	Q9Y2C9
LQSLLGLPNPALQAL	TTC28	1821	Q96AY4
VSLVPTLALLLGLPI	PIGO	321	Q8TEQ8
IPGLQILNIALPTLI	HIVEP1	2541	P15822
NPLLNSLSVLLQDLP	TMEM236	286	Q5W0B7
LLGALQSLLGTQLPP	THPO	121	P40225
QVPLPRLATGLLLLL	UGT1A4	6	P22310