Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dynein intermediate chain binding	SPTBN5 DNHD1 DNAH10 DYNLT5 DNAH5 DNAH8	1.37e-08	37	89	6	GO:0045505
GeneOntologyMolecularFunction	methyl-CpG binding	MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B	2.43e-07	31	89	5	GO:0008327
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNHD1 DNAH10 DNAH5 DNAH8	1.08e-06	18	89	4	GO:0008569
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNHD1 DNAH10 DNAH5 DNAH8	6.96e-06	28	89	4	GO:0051959
GeneOntologyMolecularFunction	microtubule motor activity	DNHD1 DNAH10 DNAH5 DNAH8	2.70e-04	70	89	4	GO:0003777
GeneOntologyBiologicalProcess	DNA methylation-dependent constitutive heterochromatin formation	MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B	1.07e-06	44	86	5	GO:0006346
GeneOntologyBiologicalProcess	facultative heterochromatin formation	MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B	3.31e-06	55	86	5	GO:0140718
GeneOntologyBiologicalProcess	heterochromatin formation	UBR2 MBD3L5 UBR5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B	5.38e-06	163	86	7	GO:0031507
GeneOntologyBiologicalProcess	negative regulation of gene expression, epigenetic	UBR2 MBD3L5 UBR5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B	2.25e-05	203	86	7	GO:0045814
GeneOntologyBiologicalProcess	chromatin organization	ZNF462 UBR2 MBD3L5 EP400 UBR5 MBD3L2 KDM3B MBD3L3 MBD3L4 CHD4 ZZEF1 TRRAP MBD3L2B	8.29e-05	896	86	13	GO:0006325
GeneOntologyBiologicalProcess	siRNA-mediated post-transcriptional gene silencing	AGO1 AGO3	1.03e-04	4	86	2	GO:0140766
GeneOntologyBiologicalProcess	siRNA-mediated gene silencing by mRNA destabilization	AGO1 AGO3	1.03e-04	4	86	2	GO:0090625
GeneOntologyBiologicalProcess	protein-DNA complex organization	ZNF462 UBR2 MBD3L5 EP400 UBR5 MBD3L2 KDM3B MBD3L3 MBD3L4 CHD4 ZZEF1 TRRAP MBD3L2B	2.43e-04	999	86	13	GO:0071824
GeneOntologyBiologicalProcess	phosphatidylinositol acyl-chain remodeling	LPGAT1 LCLAT1	2.55e-04	6	86	2	GO:0036149
GeneOntologyBiologicalProcess	intracellular magnesium ion homeostasis	TRPM7 SLC41A1	2.55e-04	6	86	2	GO:0010961
GeneOntologyCellularComponent	dynein complex	DNHD1 DNAH10 DYNLT5 DNAH5 DNAH8	3.17e-06	54	88	5	GO:0030286
GeneOntologyCellularComponent	axonemal dynein complex	DNHD1 DNAH10 DNAH5 DNAH8	3.47e-06	25	88	4	GO:0005858
GeneOntologyCellularComponent	microtubule associated complex	SPTBN5 DNHD1 DNAH10 DYNLT5 DNAH5 DNAH8	6.12e-05	161	88	6	GO:0005875
GeneOntologyCellularComponent	histone deacetylase complex	EP400 KDM3B CHD4 TRRAP	4.58e-04	85	88	4	GO:0000118
GeneOntologyCellularComponent	inner dynein arm	DNHD1 DNAH10	7.71e-04	10	88	2	GO:0036156
GeneOntologyCellularComponent	RISC-loading complex	AGO1 AGO3	7.71e-04	10	88	2	GO:0070578
GeneOntologyCellularComponent	outer dynein arm	DNAH5 DNAH8	1.13e-03	12	88	2	GO:0036157
GeneOntologyCellularComponent	Swr1 complex	EP400 TRRAP	1.33e-03	13	88	2	GO:0000812
HumanPheno	Absent sperm flagella	DNHD1 DNAH10 CFAP44 DNAH8	1.01e-05	28	26	4	HP:0032558
HumanPheno	Coiled sperm flagella	DNHD1 DNAH10 CFAP44 DNAH8	1.74e-05	32	26	4	HP:0032560
HumanPheno	Short sperm flagella	DNHD1 DNAH10 CFAP44 DNAH8	1.97e-05	33	26	4	HP:0032559
HumanPheno	Irregularly shaped sperm tail	DNHD1 DNAH10 DNAH8	5.16e-05	15	26	3	HP:0033393
HumanPheno	Abnormal sperm tail morphology	DNHD1 DNAH10 CFAP44 DNAH8	5.75e-05	43	26	4	HP:0012868
MousePheno	disorganized sperm mitochondrial sheath	SPEM2 DNAH10 DNAH8	1.47e-05	10	71	3	MP:0014468
Domain	MeCpG-bd_2/3_C_dom	MBD3L5 MBD3L2 MBD3L3 MBD3L4	1.38e-08	7	85	4	IPR025884
Domain	MBD2/MBD3_p55-bd	MBD3L5 MBD3L2 MBD3L3 MBD3L4	1.38e-08	7	85	4	IPR032343
Domain	MBD_C	MBD3L5 MBD3L2 MBD3L3 MBD3L4	1.38e-08	7	85	4	PF14048
Domain	MBDa	MBD3L5 MBD3L2 MBD3L3 MBD3L4	1.38e-08	7	85	4	PF16564
Domain	TRPM_tetra	TRPM6 TRPM7 TRPM1	3.63e-07	4	85	3	IPR032415
Domain	TRPM_tetra	TRPM6 TRPM7 TRPM1	3.63e-07	4	85	3	PF16519
Domain	Dynein_HC_stalk	DNHD1 DNAH10 DNAH5 DNAH8	3.86e-07	14	85	4	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH10 DNAH5 DNAH8	3.86e-07	14	85	4	IPR013602
Domain	DHC_N2	DNHD1 DNAH10 DNAH5 DNAH8	3.86e-07	14	85	4	PF08393
Domain	MT	DNHD1 DNAH10 DNAH5 DNAH8	3.86e-07	14	85	4	PF12777
Domain	DHC_fam	DNHD1 DNAH10 DNAH5 DNAH8	5.25e-07	15	85	4	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH10 DNAH5 DNAH8	5.25e-07	15	85	4	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH10 DNAH5 DNAH8	5.25e-07	15	85	4	PF03028
Domain	DHC_N1	DNAH10 DNAH5 DNAH8	5.01e-06	8	85	3	PF08385
Domain	Dynein_heavy_dom-1	DNAH10 DNAH5 DNAH8	5.01e-06	8	85	3	IPR013594
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DNAH5 DNAH8	3.19e-05	14	85	3	IPR024317
Domain	AAA_8	DNAH10 DNAH5 DNAH8	3.19e-05	14	85	3	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH10 DNAH5 DNAH8	3.19e-05	14	85	3	IPR011704
Domain	AAA_5	DNAH10 DNAH5 DNAH8	3.19e-05	14	85	3	PF07728
Domain	TLC	CLN8 TRAM1L1 TLCD4	4.88e-05	16	85	3	PS50922
Domain	TLC	CLN8 TRAM1L1 TLCD4	4.88e-05	16	85	3	SM00724
Domain	TRAM_LAG1_CLN8	CLN8 TRAM1L1 TLCD4	4.88e-05	16	85	3	PF03798
Domain	TLC-dom	CLN8 TRAM1L1 TLCD4	4.88e-05	16	85	3	IPR006634
Domain	Argonaute_N	AGO1 AGO3	1.22e-04	4	85	2	IPR032474
Domain	Argonaute_Mid_dom	AGO1 AGO3	1.22e-04	4	85	2	IPR032473
Domain	ArgoL2	AGO1 AGO3	1.22e-04	4	85	2	IPR032472
Domain	ArgoN	AGO1 AGO3	1.22e-04	4	85	2	PF16486
Domain	ArgoMid	AGO1 AGO3	1.22e-04	4	85	2	PF16487
Domain	ArgoL2	AGO1 AGO3	1.22e-04	4	85	2	PF16488
Domain	Acyltransf_C	LPGAT1 LCLAT1	2.03e-04	5	85	2	PF16076
Domain	DOCK_N	DOCK3 DOCK4	2.03e-04	5	85	2	PF16172
Domain	DOCK_N	DOCK3 DOCK4	2.03e-04	5	85	2	IPR032376
Domain	DUF1785	AGO1 AGO3	2.03e-04	5	85	2	SM01163
Domain	Acyltransf_C	LPGAT1 LCLAT1	2.03e-04	5	85	2	IPR032098
Domain	Alpha_kinase	TRPM6 TRPM7	3.03e-04	6	85	2	PF02816
Domain	ArgoL1	AGO1 AGO3	3.03e-04	6	85	2	PF08699
Domain	ArgoL1	AGO1 AGO3	3.03e-04	6	85	2	IPR014811
Domain	ALPHA_KINASE	TRPM6 TRPM7	3.03e-04	6	85	2	PS51158
Domain	Alpha_kinase	TRPM6 TRPM7	3.03e-04	6	85	2	SM00811
Domain	MHCK_EF2_kinase	TRPM6 TRPM7	3.03e-04	6	85	2	IPR004166
Domain	APC_su10/DOC_dom	HERC2 ZZEF1	4.24e-04	7	85	2	IPR004939
Domain	ZF_UBR	UBR2 UBR5	4.24e-04	7	85	2	PS51157
Domain	DOC	HERC2 ZZEF1	4.24e-04	7	85	2	PS51284
Domain	zf-UBR	UBR2 UBR5	4.24e-04	7	85	2	PF02207
Domain	Znf_UBR	UBR2 UBR5	4.24e-04	7	85	2	IPR003126
Domain	ZnF_UBR1	UBR2 UBR5	4.24e-04	7	85	2	SM00396
Domain	APC10	HERC2 ZZEF1	4.24e-04	7	85	2	SM01337
Domain	ANAPC10	HERC2 ZZEF1	4.24e-04	7	85	2	PF03256
Domain	PIWI	AGO1 AGO3	5.63e-04	8	85	2	PS50822
Domain	Piwi	AGO1 AGO3	5.63e-04	8	85	2	SM00950
Domain	Piwi	AGO1 AGO3	5.63e-04	8	85	2	IPR003165
Domain	Piwi	AGO1 AGO3	5.63e-04	8	85	2	PF02171
Domain	PAZ	AGO1 AGO3	7.22e-04	9	85	2	PS50821
Domain	PAZ	AGO1 AGO3	7.22e-04	9	85	2	SM00949
Domain	PAZ_dom	AGO1 AGO3	7.22e-04	9	85	2	IPR003100
Domain	PAZ	AGO1 AGO3	7.22e-04	9	85	2	PF02170
Domain	DOCK_C	DOCK3 DOCK4	1.10e-03	11	85	2	IPR010703
Domain	DHR-1_domain	DOCK3 DOCK4	1.10e-03	11	85	2	IPR027007
Domain	DHR_2	DOCK3 DOCK4	1.10e-03	11	85	2	PS51651
Domain	DHR_1	DOCK3 DOCK4	1.10e-03	11	85	2	PS51650
Domain	DOCK-C2	DOCK3 DOCK4	1.10e-03	11	85	2	PF14429
Domain	DHR-2	DOCK3 DOCK4	1.10e-03	11	85	2	IPR027357
Domain	DHR-2	DOCK3 DOCK4	1.10e-03	11	85	2	PF06920
Domain	DOCK	DOCK3 DOCK4	1.10e-03	11	85	2	IPR026791
Domain	-	EXD3 AGO1 AGO3	1.28e-03	47	85	3	3.30.420.10
Domain	Acyltransferase	LPGAT1 LCLAT1	2.36e-03	16	85	2	PF01553
Domain	-	PIK3C2B TRRAP	2.36e-03	16	85	2	1.10.1070.11
Domain	PI3Kc	PIK3C2B TRRAP	2.36e-03	16	85	2	SM00146
Domain	PlsC	LPGAT1 LCLAT1	2.66e-03	17	85	2	SM00563
Domain	Plipid/glycerol_acylTrfase	LPGAT1 LCLAT1	2.66e-03	17	85	2	IPR002123
Domain	PI3/4_kinase_cat_dom	PIK3C2B TRRAP	2.99e-03	18	85	2	IPR000403
Domain	ZZ	HERC2 ZZEF1	2.99e-03	18	85	2	PF00569
Domain	PI3_PI4_kinase	PIK3C2B TRRAP	2.99e-03	18	85	2	PF00454
Domain	PI3_4_KINASE_3	PIK3C2B TRRAP	2.99e-03	18	85	2	PS50290
Domain	ZF_ZZ_2	HERC2 ZZEF1	2.99e-03	18	85	2	PS50135
Domain	PI3_4_KINASE_1	PIK3C2B TRRAP	2.99e-03	18	85	2	PS00915
Domain	PI3_4_KINASE_2	PIK3C2B TRRAP	2.99e-03	18	85	2	PS00916
Domain	ZF_ZZ_1	HERC2 ZZEF1	2.99e-03	18	85	2	PS01357
Domain	Kinase-like_dom	TRPM6 PHKG1 BMPR2 TRPM7 PIK3C2B RIOK3 TRRAP PRAG1	3.25e-03	542	85	8	IPR011009
Domain	Znf_ZZ	HERC2 ZZEF1	3.33e-03	19	85	2	IPR000433
Domain	ZnF_ZZ	HERC2 ZZEF1	3.33e-03	19	85	2	SM00291
Domain	RNaseH-like_dom	EXD3 AGO1 AGO3	3.84e-03	69	85	3	IPR012337
Domain	-	UBR5 HERC2	4.46e-03	22	85	2	2.130.10.30
Domain	ARM-type_fold	DOCK3 PDS5B PIK3C2B RANBP6 RALGAPA2 TRRAP	4.50e-03	339	85	6	IPR016024
Pathway	REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS	AGO1 AGO3 TRPM1	7.83e-05	19	63	3	M48238
Pathway	REACTOME_MICRORNA_MIRNA_BIOGENESIS	AGO1 AGO3 POLR2A	1.82e-04	25	63	3	M712
Pathway	BIOCARTA_DICER_PATHWAY	AGO1 AGO3	1.95e-04	5	63	2	M22079
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH10 DNAH5 DNAH8	2.30e-04	27	63	3	M47755
Pathway	REACTOME_TRP_CHANNELS	TRPM6 TRPM7 TRPM1	2.57e-04	28	63	3	MM14943
Pathway	REACTOME_TRP_CHANNELS	TRPM6 TRPM7 TRPM1	2.57e-04	28	63	3	M27241
Pathway	REACTOME_MICRORNA_MIRNA_BIOGENESIS	AGO1 AGO3	2.91e-04	6	63	2	MM14818
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	AGO1 AGO3	2.91e-04	6	63	2	MM15083
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	AGO1 AGO3	4.07e-04	7	63	2	M46421
Pathway	REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS	AGO1 AGO3	5.41e-04	8	63	2	MM15082
Pathway	REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS	AGO1 AGO3	6.93e-04	9	63	2	M27340
Pathway	REACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION	AGO1 AGO3	6.93e-04	9	63	2	M27810
Pathway	REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION	AGO1 AGO3	6.93e-04	9	63	2	M46436
Pathway	REACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS	AGO1 AGO3	8.64e-04	10	63	2	M48013
Pathway	KEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT	DNAH10 DNAH5 DNAH8	9.24e-04	43	63	3	M47669
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH10 DNAH5 DNAH8	1.06e-03	45	63	3	M47670
Pubmed	MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.	MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B	5.86e-13	6	89	5	12504854
Pubmed	Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.	MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B	5.86e-13	6	89	5	18942147
Pubmed	MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.	MBD3L5 MBD3L2 MBD3L3 MBD3L4 CHD4 MBD3L2B	1.16e-12	15	89	6	15701600
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	SPTBN5 DNHD1 DNAH10 CFAP44 ZZEF1 TRRAP DNAH8	5.51e-07	187	89	7	26460568
Pubmed	Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.	TRPM6 TRPM7 SLC41A1	8.99e-07	8	89	3	33859252
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	AGO1 AGO3 UBR5 HERC2 TRRAP	1.57e-06	76	89	5	27542412
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	PDS5B NDC1 CMTR1 EP400 SBNO1 POLR2A KDM3B TRRAP	2.79e-06	341	89	8	32971831
Pubmed	Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons.	TRPM6 TRPM7 TRPM1	3.50e-06	12	89	3	19850157
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF462 DOCK3 CMTR1 UTP14A DIP2C LPGAT1 RALGAPA2 PCYOX1 SLC45A4	5.00e-06	493	89	9	15368895
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH10 DNAH5 DNAH8	5.78e-06	14	89	3	9373155
Pubmed	The channel kinases TRPM6 and TRPM7 are functionally nonredundant.	TRPM6 TRPM7	6.48e-06	2	89	2	16150690
Pubmed	TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP.	TRPM6 TRPM7	6.48e-06	2	89	2	28821869
Pubmed	Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.	TRPM6 TRPM7	6.48e-06	2	89	2	16636202
Pubmed	Recent developments in intestinal magnesium absorption.	TRPM6 TRPM7	6.48e-06	2	89	2	18301276
Pubmed	The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC.	TRPM6 TRPM7	6.48e-06	2	89	2	18675813
Pubmed	The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1.	CYP4Z2P CYP4Z1	6.48e-06	2	89	2	25701119
Pubmed	The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer.	CYP4Z2P CYP4Z1	6.48e-06	2	89	2	28236635
Pubmed	TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions.	TRPM6 TRPM7	6.48e-06	2	89	2	24858416
Pubmed	Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases.	TRPM6 TRPM7	6.48e-06	2	89	2	28220887
Pubmed	Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women.	TRPM6 TRPM7	6.48e-06	2	89	2	19149903
Pubmed	Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7.	TRPM6 TRPM7	6.48e-06	2	89	2	18365021
Pubmed	Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.	CYP4Z2P CYP4Z1	6.48e-06	2	89	2	15059886
Pubmed	Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.	TRPM6 TRPM7	6.48e-06	2	89	2	14976260
Pubmed	Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension.	TRPM6 TRPM7	6.48e-06	2	89	2	18192217
Pubmed	Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells.	AGO1 POLR2A	6.48e-06	2	89	2	16936726
Pubmed	Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia.	TRPM6 TRPM7	6.48e-06	2	89	2	21602712
Pubmed	Enhanced susceptibility of Ago1/3 double-null mice to influenza A virus infection.	AGO1 AGO3	6.48e-06	2	89	2	22318144
Pubmed	Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin.	TRPM6 TRPM7	6.48e-06	2	89	2	26563869
Pubmed	The Different Roles of The Channel-Kinases TRPM6 and TRPM7.	TRPM6 TRPM7	6.48e-06	2	89	2	26179995
Pubmed	Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis.	TRPM6 TRPM7	6.48e-06	2	89	2	16075242
Pubmed	Evidence for the expression of TRPM6 and TRPM7 in cardiomyocytes from all four chamber walls of the human heart.	TRPM6 TRPM7	6.48e-06	2	89	2	34326388
Pubmed	Differential mRNA expression and glucocorticoid-mediated regulation of TRPM6 and TRPM7 in the heart and kidney throughout murine pregnancy and development.	TRPM6 TRPM7	6.48e-06	2	89	2	25692682
Pubmed	TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon.	TRPM6 TRPM7	6.48e-06	2	89	2	29912157
Pubmed	Magnesium and its transporters in cancer: a novel paradigm in tumour development.	TRPM6 TRPM7	6.48e-06	2	89	2	22671428
Pubmed	The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels.	TRPM6 TRPM7	6.48e-06	2	89	2	24385424
Pubmed	Gene variation of the transient receptor potential cation channel, subfamily M, members 6 (TRPM6) and 7 (TRPM7), and type 2 diabetes mellitus: a case-control study.	TRPM6 TRPM7	6.48e-06	2	89	2	20875900
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	ATP5PB PDS5B CMTR1 POLR2A UTP14A RANBP6 CHD4 HERC2 TRRAP	9.35e-06	533	89	9	30554943
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TRPM6 ATP5PB DNHD1 PDS5B S100A9 NDC1 DNAH10 SBNO1 POLR2A UTP14A CHD4 DNAH5 PCYOX1 TMEM117	1.52e-05	1425	89	14	30948266
Pubmed	Turning catalytically inactive human Argonaute proteins into active slicer enzymes.	AGO1 AGO3	1.94e-05	3	89	2	23665583
Pubmed	Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.	TRPM7 SLC41A1	1.94e-05	3	89	2	35163580
Pubmed	The roles of individual mammalian argonautes in RNA interference in vivo.	AGO1 AGO3	1.94e-05	3	89	2	24992693
Pubmed	Argonaute proteins in cardiac tissue contribute to the heart injury during viral myocarditis.	AGO1 AGO3	1.94e-05	3	89	2	26764146
Pubmed	N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation.	TRPM6 TRPM7	1.94e-05	3	89	2	25277194
Pubmed	Ago1 Interacts with RNA polymerase II and binds to the promoters of actively transcribed genes in human cancer cells.	AGO1 POLR2A	1.94e-05	3	89	2	24086155
Pubmed	TRPV6, TRPM6 and TRPM7 Do Not Contribute to Hair-Cell Mechanotransduction.	TRPM6 TRPM7	1.94e-05	3	89	2	29515374
Pubmed	Argonaute2 is the catalytic engine of mammalian RNAi.	AGO1 AGO3	1.94e-05	3	89	2	15284456
Pubmed	Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells.	CYP4Z2P CYP4Z1	1.94e-05	3	89	2	30832689
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DOCK3 EP400 PIK3C2B POLR2A KDM3B DIP2C HERC2 RALGAPA2 ZZEF1 TRRAP PRAG1 WDR24	2.49e-05	1105	89	12	35748872
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	EP400 SBNO1 POLR2A UTP14A KDM3B CHD4 TRRAP	2.73e-05	339	89	7	30415952
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPM6 TRPM7 TRPM1	3.15e-05	24	89	3	33884443
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPM6 TRPM7 TRPM1	3.58e-05	25	89	3	16382100
Pubmed	P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma.	EP400 UBR5 TRRAP	3.58e-05	25	89	3	36708875
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	S100A9 CMTR1 EP400 UBR5 SBNO1 KDM3B CHD4	3.79e-05	357	89	7	37059091
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	ZNF462 EP400 POLR2A CHD4 TRRAP	3.80e-05	146	89	5	23892456
Pubmed	Molecular dissection of human Argonaute proteins by DNA shuffling.	AGO1 AGO3	3.87e-05	4	89	2	23748378
Pubmed	Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.	AGO1 AGO3	3.87e-05	4	89	2	15260970
Pubmed	A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.	UBR2 UBR5	3.87e-05	4	89	2	16055722
Pubmed	A mouse homologue of Strawberry Notch is transcriptionally regulated by Reelin signal.	RELN SBNO1	3.87e-05	4	89	2	17045962
Pubmed	The substrate recognition domains of the N-end rule pathway.	UBR2 UBR5	3.87e-05	4	89	2	19008229
Pubmed	Identification of Xin-repeat proteins as novel ligands of the SH3 domains of nebulin and nebulette and analysis of their interaction during myofibril formation and remodeling.	XIRP2 NEB	3.87e-05	4	89	2	23985323
Pubmed	Cholinergic Regulation of hnRNPA2/B1 Translation by M1 Muscarinic Receptors.	SLC18A3 CHRM2	3.87e-05	4	89	2	27277805
Pubmed	Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis.	ESR2 POLR2A	3.87e-05	4	89	2	25479752
Pubmed	Slicing-independent RISC activation requires the argonaute PAZ domain.	AGO1 AGO3	3.87e-05	4	89	2	22795694
Pubmed	ATP-dependent human RISC assembly pathways.	AGO1 AGO3	3.87e-05	4	89	2	19966796
Pubmed	Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.	AGO1 AGO3	3.87e-05	4	89	2	18771919
Pubmed	A Requirement for Argonaute 4 in Mammalian Antiviral Defense.	AGO1 AGO3	3.87e-05	4	89	2	32049003
Pubmed	Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest.	EP400 UBR5 TRRAP	4.53e-05	27	89	3	21320693
Pubmed	An introduction to TRP channels.	TRPM6 TRPM7 TRPM1	4.53e-05	27	89	3	16460286
Pubmed	Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.	AGO1 AGO3	6.44e-05	5	89	2	12526743
Pubmed	Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells.	AGO1 AGO3	6.44e-05	5	89	2	19393748
Pubmed	Differential expression of components of the microRNA machinery during mouse organogenesis.	AGO1 AGO3	6.44e-05	5	89	2	16036130
Pubmed	Quantitative functions of Argonaute proteins in mammalian development.	AGO1 AGO3	6.44e-05	5	89	2	22474261
Pubmed	The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.	AGO1 AGO3	6.44e-05	5	89	2	12414724
Pubmed	Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer.	SBNO1 TRRAP	6.44e-05	5	89	2	17308053
Pubmed	Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte.	TRPM7 TRPM1	6.44e-05	5	89	2	16857711
Pubmed	The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.	AGO1 AGO3	6.44e-05	5	89	2	19324964
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	ZNF462 EP400 POLR2A CHD4 TRRAP	7.20e-05	167	89	5	20362541
Pubmed	Nuclear heterogeneous nuclear ribonucleoprotein D is associated with poor prognosis and interactome analysis reveals its novel binding partners in oral cancer.	S100A9 AGO1 AGO3 POLR2A	7.93e-05	88	89	4	26318153
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPM6 TRPM7 TRPM1	8.36e-05	33	89	3	19834762
Pubmed	Alpha-kinases: a new class of protein kinases with a novel catalytic domain.	TRPM6 TRPM7	9.65e-05	6	89	2	10021370
Pubmed	Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex.	EP400 TRRAP	9.65e-05	6	89	2	20070254
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ZNF462 PDS5B S100A9 RELN AGO1 EP400 POLR2A UTP14A DPYSL4 CHD4 TRRAP	1.00e-04	1082	89	11	38697112
Pubmed	Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses.	RASGRP4 POLR2A	1.35e-04	7	89	2	30720883
Pubmed	Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins.	AGO1 AGO3	1.35e-04	7	89	2	28683311
Pubmed	Functional dissection of the human TNRC6 (GW182-related) family of proteins.	AGO1 AGO3	1.35e-04	7	89	2	19470757
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH5 DNAH8	1.35e-04	7	89	2	9256245
Pubmed	Genome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development.	AGO1 AGO3	1.35e-04	7	89	2	34907157
Pubmed	Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival.	TRPM6 TRPM7	1.35e-04	7	89	2	27991852
Pubmed	Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.	AGO1 AGO3	1.35e-04	7	89	2	19536157
Pubmed	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.	AGO1 AGO3	1.35e-04	7	89	2	19383768
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH5 DNAH8	1.35e-04	7	89	2	31178125
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	PDS5B EP400 POLR2A CHD4 TRRAP	1.49e-04	195	89	5	19454010
Pubmed	Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.	EP400 KDM3B TRRAP	1.73e-04	42	89	3	35705031
Pubmed	Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis.	AGO1 AGO3	1.79e-04	8	89	2	19345100
Pubmed	Suppression of microRNA Activity in Kidney Collecting Ducts Induces Partial Loss of Epithelial Phenotype and Renal Fibrosis.	AGO1 AGO3	1.79e-04	8	89	2	29021386
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	TRPM6 TRPM7 TRPM1	1.99e-04	44	89	3	19322198
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	UBR2 EP400 POLR2A CHD4 TRRAP	2.15e-04	211	89	5	17314511
Pubmed	Identification of eight members of the Argonaute family in the human genome.	AGO1 AGO3	2.30e-04	9	89	2	12906857
Pubmed	The OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin.	UBR5 POLR2A	2.30e-04	9	89	2	30508113
Pubmed	The p400 complex is an essential E1A transformation target.	EP400 TRRAP	2.30e-04	9	89	2	11509179
Interaction	H2BC9 interactions	PDS5B DNAH10 SBNO1 XIRP2 POLR2A CHD4 TRPM1 NEB CFAP44 TRRAP DNAH5	2.12e-06	446	83	11	int:H2BC9
Interaction	GAN interactions	SPTBN5 DNHD1 DNAH10 ESR2 CFAP44 ZZEF1 TRRAP DNAH8	9.67e-06	253	83	8	int:GAN
Interaction	ATOH1 interactions	AGO1 AGO3 UBR5 HERC2 TRRAP	1.98e-05	80	83	5	int:ATOH1
Interaction	SLX4 interactions	ZNF462 PDS5B S100A9 CMTR1 EP400 UBR5 SBNO1 ESR2 POLR2A KDM3B CHD4	2.22e-05	572	83	11	int:SLX4
Cytoband	19p13.2	MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B	8.73e-05	229	89	5	19p13.2
Cytoband	15q21	SPTBN5 TRPM7	2.02e-04	11	89	2	15q21
Cytoband	12q24.31	DNAH10 SBNO1 COQ5	5.19e-04	80	89	3	12q24.31
GeneFamily	TLC domain containing	CLN8 TRAM1L1 TLCD4	2.81e-06	10	53	3	1374
GeneFamily	Dyneins, axonemal	DNAH10 DNAH5 DNAH8	1.57e-05	17	53	3	536
GeneFamily	Transient receptor potential cation channels	TRPM6 TRPM7 TRPM1	7.40e-05	28	53	3	249
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR2 UBR5	1.75e-04	7	53	2	785
GeneFamily	Argonaute/PIWI family	AGO1 AGO3	2.33e-04	8	53	2	408
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	HERC2 ZZEF1	1.25e-03	18	53	2	91
GeneFamily	Cytochrome P450 family 4	CYP4Z2P CYP4Z1	4.98e-03	36	53	2	1003
GeneFamily	Solute carriers	SLC25A40 SLC18A3 SLC24A3 SLC41A1 SLC45A4	5.89e-03	395	53	5	752
Coexpression	GSE36078_UNTREATED_VS_AD5_INF_IL1R_KO_MOUSE_LUNG_DC_UP	TRPM6 AGO1 UTP14A KDM3B DYNLT5 FAM131A TRPM1	5.10e-06	200	88	7	M9301
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	DOCK3 TRPM7 XIRP2 SLC41A1 CHRM2 LCLAT1	1.94e-06	187	88	6	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	OR4K2 AGO1 AGO3 UBR5 CCDC168	7.24e-06	135	88	5	3351e8b9e417397c5fa9f856184ff24ce1a27242
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	OR4K2 AGO1 AGO3 CHD4 CCDC168	1.17e-05	149	88	5	768877bade04ca0321593b8470b5011ad8270431
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 DYNLT5 CES4A CFAP44 DNAH5	2.15e-05	169	88	5	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYT8 DNAH10 DYNLT5 CFAP44 DNAH5	2.90e-05	180	88	5	1f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCell	critical-Myeloid-Mast_cell\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ZNF462 EXD3 DIP2C SLC24A3 PRAG1	2.98e-05	181	88	5	f0d81ae74d3f32979624a94b2ef93774831a7970
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN OR4K2 GPR149 SLC24A3 CHRM2	3.06e-05	182	88	5	d3a037268f026eb2f84428b1821022503cef7756
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN DNAH10 XIRP2 NEB DNAH5	3.22e-05	184	88	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN DNAH10 XIRP2 NEB DNAH5	3.22e-05	184	88	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN DNAH10 XIRP2 NEB DNAH5	3.22e-05	184	88	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH10 DYNLT5 CES4A CFAP44 DNAH5	3.31e-05	185	88	5	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYT8 DNAH10 DYNLT5 CFAP44 DNAH5	3.66e-05	189	88	5	b4b93bd10b7e3cc16e54ff73beac230f519c010a
ToppCell	RA-09._Endothelium_I\|World / Chamber and Cluster_Paper	DOCK4 BMPR2 PIK3C2B RALGAPA2 PRAG1	3.85e-05	191	88	5	c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCell	RA-09._Endothelium_I\|RA / Chamber and Cluster_Paper	DOCK4 BMPR2 PIK3C2B RALGAPA2 PRAG1	3.95e-05	192	88	5	8a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCell	COPD-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	CYP4Z2P DNAH10 DYNLT5 CFAP44 DNAH5	3.95e-05	192	88	5	eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCell	wk_08-11-Hematologic-Meg-ery-Definitive_erythroblast\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CLN8 UBR2 RELN TLCD4 RIOK3	4.05e-05	193	88	5	be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH10 DYNLT5 CES4A CFAP44 DNAH5	4.05e-05	193	88	5	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 DYNLT5 CES4A CFAP44 DNAH5	4.15e-05	194	88	5	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DNAH10 DYNLT5 CES4A CFAP44 DNAH5	4.25e-05	195	88	5	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	moderate-Epithelial-Ciliated\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DNAH10 DYNLT5 CES4A CFAP44 DNAH5	4.25e-05	195	88	5	e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	ZNF462 DOCK4 RELN BMPR2 PRAG1	4.36e-05	196	88	5	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYT8 DNAH10 DYNLT5 CFAP44 DNAH5	4.46e-05	197	88	5	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	Biopsy_Control_(H.)-Epithelial-Ciliated\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	SYT8 DNAH10 DYNLT5 CFAP44 DNAH5	4.79e-05	200	88	5	9ae434c78e08adf95da49c85616e3ca72d1227bf
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Ciliated\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	DNAH10 DYNLT5 CES4A CFAP44 DNAH5	4.79e-05	200	88	5	6a2ccc71a0cbe04a542c379b28b5006de53981c3
Disease	Global developmental delay	ZNF462 AGO1 POLR2A KDM3B TRRAP	4.24e-05	133	85	5	C0557874
Disease	10-undecenoate 11:1n1 measurement	CYP4Z2P CYP4Z1	1.71e-04	7	85	2	EFO_0021099
Disease	MASA syndrome (implicated_via_orthology)	TRPM7 TRPM1	1.71e-04	7	85	2	DOID:0060246 (implicated_via_orthology)
Disease	osteoarthritis	RELN DNAH10 SBNO1 PRAG1 CHRM2	4.64e-04	222	85	5	MONDO_0005178
Disease	asymmetric dimethylarginine measurement	SLC24A3 ZZEF1	7.30e-04	14	85	2	EFO_0010463
Disease	Generalized hypotonia	AGO1 POLR2A	8.40e-04	15	85	2	C1858120
Disease	Autistic Disorder	DOCK4 RELN AGO1 CHD4 TRRAP	9.61e-04	261	85	5	C0004352
Disease	chronotype measurement	ZNF462 DOCK3 RELN EXD3 ESR2 DIP2C PRAG1 PRRC1 PCYOX1	9.90e-04	882	85	9	EFO_0008328
Disease	Schizophrenia	DOCK4 S100A9 RELN SBNO1 ESR2 CHD4 TRPM1 TRRAP CHRM2	9.98e-04	883	85	9	C0036341
Disease	bipolar disorder (is_marker_for)	RELN CHRM2	1.36e-03	19	85	2	DOID:3312 (is_marker_for)
Disease	Manic	RELN DRD5 DNAH8	1.50e-03	78	85	3	C0338831
Disease	attention deficit hyperactivity disorder (is_implicated_in)	DOCK3 DRD5	1.51e-03	20	85	2	DOID:1094 (is_implicated_in)
Disease	depressive disorder (implicated_via_orthology)	DRD5 ESR2	1.82e-03	22	85	2	DOID:1596 (implicated_via_orthology)
Disease	anxiety disorder (implicated_via_orthology)	ESR2 KDM3B	1.82e-03	22	85	2	DOID:2030 (implicated_via_orthology)
Disease	migraine disorder, Headache	ZNF462 GPR149 SLC24A3	1.99e-03	86	85	3	HP_0002315, MONDO_0005277
Disease	Ovarian Serous Adenocarcinoma	TRPM7 TRRAP	1.99e-03	23	85	2	C1335177
Disease	colon adenocarcinoma (is_implicated_in)	UBR5 CHD4	2.55e-03	26	85	2	DOID:234 (is_implicated_in)
Disease	Adenocarcinoma of large intestine	PHKG1 UBR5 TRRAP	2.72e-03	96	85	3	C1319315

Protein segments in the cluster

Peptide	Gene	Start	Entry
MSKSVRMMLNKWEEH	CYP4Z2P	156	Q8N1L4
MQRVKGMTERHWEAV	EP400	1221	Q96L91
MMMSDNAKGRAAHSW	DYNLT5	1	Q8N7M0
HQSVRPAMWKMMLNI	AGO1	201	Q9UL18
PAMWKMMLNIDVSAT	AGO1	206	Q9UL18
TTKMAGMMIAAAWVL	CHRM2	136	P08172
ALLEWGTLAMVSMHM	DNHD1	1526	Q96M86
SVRPAMWKMMLNIDV	AGO3	206	Q9H9G7
QMMTMHNTKGRTWSL	MT-ATP6	56	P00846
QMRWELMMKTKEHTR	CFAP44	1751	Q96MT7
MMRRKEQEHMINWVE	ATP5PB	206	P24539
IQAIKMMVRWLLGMK	PDS5B	826	Q9NTI5
MMVRWLLGMKNNHSK	PDS5B	831	Q9NTI5
KMTQRMALVMVGLAW	DRD5	151	P21918
DKGLVVAQMMWLMDH	LPGAT1	116	Q92604
MEVLMMGLMWRSIDH	ESR2	336	Q92731
MMKIGTRVMRGVDWK	HERC2	1866	O95714
RSVIIMNHRTRMDWM	LCLAT1	116	Q6UWP7
NMMPWALQKKREIHM	MBD3L5	21	A6NJ08
RMHMWVEDVLDKFMR	PCYOX1	151	Q9UHG3
MNPHLCLKMIIMIWS	OR2W1	136	Q9Y3N9
VASWIMGVMHSMSQV	OR4K2	146	Q8NGD2
NEHDWKMLRNRMMDI	CES4A	406	Q5XG92
MMTNKAMKQRHWDRI	DNAH8	1351	Q96JB1
MLNMVLAMHSWVLPS	RASGRP4	81	Q8TDF6
NMMPWALQKKREIHM	MBD3L2B	21	A0A1B0GVZ6
KEAMMMVEPHQKVAW	KDM3B	1006	Q7LBC6
RMIMELTMNKKTWEQ	RALGAPA2	551	Q2PPJ7
GEDRKWMMARKLMQV	SLC24A3	56	Q9HC58
WMMARKLMQVNDTLT	SLC24A3	61	Q9HC58
KMRSHMALDWIMKER	LIX1	201	Q8N485
NMMPWALQKKREIHM	MBD3L3	21	A6NE82
QMSVWLMLANEGMVK	RELN	1251	P78509
MSKIWVQEGLDMRMV	PIK3C2B	1101	O00750
VLWLPMMMHMVVQNV	GPR149	321	Q86SP6
EMHMVDTVTWHKMRG	PORCN	111	Q9H237
DTVTWHKMRGAQMIV	PORCN	116	Q9H237
MWRMKQHAAVLEEGV	PAPSS1	466	O43252
RMSMVWEKCVASGKM	DPYSL4	361	O14531
VMMDILLDWSMHNIL	GDE1	251	Q9NZC3
RNIMIPIFHDMMDWE	DOCK3	1111	Q8IZD9
LRNVMIPIFHDMMDW	DOCK4	1081	Q8N1I0
SWGVRILHVDEMMMH	DBF4B	176	Q8NFT6
MAELMMIWERNKSVS	BMPR2	501	Q13873
VGLWHGILTSVMNMM	DIP2C	546	Q9Y2E4
MPMISVLGKMFLWQR	FAM131A	1	Q6UXB0
VMNDMMSLGIHRVWK	COQ5	81	Q5HYK3
MQWNMTDKMVNVKHR	CCDC168	3601	Q8NDH2
IAVSKMMMVLGAKWR	CHD4	196	Q14839
AMMSALRMVWIISRH	DNAH10	366	Q8IVF4
SNKEGARMWINDMKM	SBNO1	196	A3KN83
MSDWMVVGKRKMIIE	CMTR1	171	Q8N1G2
MASKAMMERHWERIT	DNAH5	1486	Q8TE73
NMMPWALQKKREIHM	MBD3L4	21	A6NDZ8
NMMPWALQKKREIHM	MBD3L2	21	Q8NHZ7
WHRKQMLMLRMIMSG	PHKG1	231	Q16816
MLHLHGWQTMQGRKM	SYT8	1	Q8NBV8
MKHTMAASEWEMGMA	SLC18A3	316	Q16572
MLMARLTWASHEKMH	S100A9	81	P06702
HAMMMKSWKIAIESL	BMT2	286	Q1RMZ1
SMPLHMSTWIIMKNI	SLC25A40	276	Q8TBP6
MDTPKELWRMITGNM	SLC41A1	166	Q8IVJ1
DWHMAFTGMSRRQMI	PRRC1	411	Q96M27
MTKEHIMQMLQSPDW	RANBP6	366	O60518
LMQWMEEKGLMAAHE	SPTBN5	1326	Q9NRC6
KLNQWLMIHMFHCRM	CLN8	191	Q9UBY8
MSESVRMMLNKWEEH	CYP4Z1	156	Q86W10
RMWAEKEMHNLARMQ	RIOK3	326	O14730
RIPMRLWVMHGAVMF	SLC45A4	46	Q5BKX6
WMFETRPLDSMNKMH	XIRP2	481	A4UGR9
LIWKARPHSMMTFQM	TRAM1L1	151	Q8N609
MAWKSSVIMQMGRFL	TMIGD1	1	Q6UXZ0
LLVWAVLMKRQKMAM	TRPM6	611	Q9BX84
VLMKRQKMAMFFWQH	TRPM6	616	Q9BX84
MMWHGLQNALDKMID	SPEM2	46	Q0P670
KMSMMGHRVRILPWS	POLR2A	466	P24928
MGITWFKISLEMMEK	MTHFSD	221	Q2M296
MSSLKQGKEPWMMER	ZNF840P	91	A6NDX5
KIMQVNGWDMTMVTH	TAX1BP3	76	O14907
LDVMNVMWMIKISKG	TLCD4	226	Q96MV1
MMERMSLKHQNSGKW	UTP14A	291	Q9BVJ6
LHNWIDMKRALMMMK	PRAG1	1351	Q86YV5
MVWAVLMKRQKMAVF	TRPM1	616	Q7Z4N2
IRIWMLEMKQKSLMS	ZZEF1	1381	O43149
ERWCDHMMKKHRSMV	ZNF462	256	Q96JM2
VTAWMVTDMMLQDKP	TMEM117	166	Q9H0C3
MVKVWDMTTHRAKEM	WDR24	231	Q96S15
ASRDRMVMMWDLHGS	WDR31	121	Q8NA23
QMKLTHVISMMQDWC	UBR2	541	Q8IWV8
DKFCDQMMQHLRKWM	TRRAP	1461	Q9Y4A5
QMMQHLRKWMEVVVI	TRRAP	1466	Q9Y4A5
HQSTEGMSIKMVLMW	SLC66A2	196	Q8N2U9
MLLSDMWMGRLNMRK	TRPM7	741	Q96QT4
MGMVISHDMLLGRWR	UBR5	2176	O95071
DMMKQLMWLSSHQEG	EXD3	741	Q8N9H8
MHSFIHAAMGMVMAW	NDC1	116	Q9BTX1
RNIEDDPKMMWSMHV	NEB	2566	P20929
DPKMMWSMHVAKIQS	NEB	2571	P20929
KMMWSMHVAKIQSDR	NEB	2816	P20929
ARNIEDDPKMMWSMH	NEB	3051	P20929
DDPKMMWSMHVAKIQ	NEB	3056	P20929