Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction6-phosphofructo-2-kinase activity

PFKFB1 PFKFB2

5.13e-054592GO:0003873
GeneOntologyMolecularFunctionfructose-2,6-bisphosphate 2-phosphatase activity

PFKFB1 PFKFB2

8.53e-055592GO:0004331
GeneOntologyMolecularFunctionfour-way junction helicase activity

WRN FANCM

1.28e-046592GO:0009378
GeneOntologyMolecularFunctionphosphofructokinase activity

PFKFB1 PFKFB2

1.79e-047592GO:0008443
GeneOntologyMolecularFunctionsugar-phosphatase activity

PFKFB1 PFKFB2

3.80e-0410592GO:0050308
GeneOntologyMolecularFunctioncarbohydrate phosphatase activity

PFKFB1 PFKFB2

4.64e-0411592GO:0019203
GeneOntologyMolecularFunctioncomplement component C3b binding

CFH VSIG4

5.56e-0412592GO:0001851
GeneOntologyMolecularFunctioncalcium channel activity

CACNB1 TRPM3 CNGB1 RYR2

5.75e-04129594GO:0005262
GeneOntologyMolecularFunction3'-5' DNA helicase activity

WRN FANCM

1.00e-0316592GO:0043138
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNB1 TRPM3 CNGB1 RYR2

1.04e-03151594GO:0015085
GeneOntologyMolecularFunctionfour-way junction DNA binding

WRN FANCM

1.42e-0319592GO:0000400
GeneOntologyMolecularFunctioncarbohydrate kinase activity

PFKFB1 PFKFB2

1.74e-0321592GO:0019200
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

TSR1 WRN SMC4 CCT8 NKIRAS1 FANCM GEM AQR

1.91e-03775598GO:0017111
GeneOntologyMolecularFunctionextracellular matrix structural constituent

FRAS1 FBLN5 SBSPON ACAN

2.31e-03188594GO:0005201
GeneOntologyMolecularFunctionopsonin binding

CFH VSIG4

2.46e-0325592GO:0001846
GeneOntologyMolecularFunctionprotein kinase A regulatory subunit binding

AKAP6 RYR2

2.46e-0325592GO:0034237
GeneOntologyMolecularFunctionpyrophosphatase activity

TSR1 WRN SMC4 CCT8 NKIRAS1 FANCM GEM AQR

3.12e-03839598GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

TSR1 WRN SMC4 CCT8 NKIRAS1 FANCM GEM AQR

3.15e-03840598GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

TSR1 WRN SMC4 CCT8 NKIRAS1 FANCM GEM AQR

3.15e-03840598GO:0016818
GeneOntologyMolecularFunctioncomplement binding

CFH VSIG4

4.02e-0332592GO:0001848
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

CNGB1 RYR2

4.27e-0333592GO:0005217
Domain6Pfruct_kin

PFKFB1 PFKFB2

5.66e-054582IPR003094
Domain6Phosfructo_kin

PFKFB1 PFKFB2

5.66e-054582IPR013079
Domain6PF2K

PFKFB1 PFKFB2

5.66e-054582PF01591
DomainCalx_beta

FRAS1 ADGRV1

2.62e-048582SM00237
DomainPG/BPGM_mutase_AS

PFKFB1 PFKFB2

3.36e-049582IPR001345
DomainCalx_beta

FRAS1 ADGRV1

3.36e-049582IPR003644
DomainCalx-beta

FRAS1 ADGRV1

3.36e-049582PF03160
DomainPGAM

PFKFB1 PFKFB2

4.20e-0410582SM00855
DomainPG_MUTASE

PFKFB1 PFKFB2

4.20e-0410582PS00175
Domain-

CACNB1 WRN SMC4 PFKFB1 PFKFB2 NKIRAS1 FANCM GEM AQR

4.54e-047465893.40.50.300
DomainHis_Phos_1

PFKFB1 PFKFB2

6.13e-0412582PF00300
DomainHis_Pase_superF_clade-1

PFKFB1 PFKFB2

6.13e-0412582IPR013078
DomainCNH

NRK MAP4K2

8.42e-0414582SM00036
DomainCNH

NRK MAP4K2

9.70e-0415582PF00780
DomainCNH

NRK MAP4K2

9.70e-0415582PS50219
DomainCNH_dom

NRK MAP4K2

9.70e-0415582IPR001180
DomainP-loop_NTPase

CACNB1 WRN SMC4 PFKFB1 PFKFB2 NKIRAS1 FANCM GEM AQR

1.13e-03848589IPR027417
DomainHis_PPase_superfam

PFKFB1 PFKFB2

1.74e-0320582IPR029033
Domain-

PFKFB1 PFKFB2

1.74e-03205823.40.50.1240
DomainIon_trans_dom

TRPM3 CNGB1 RYR2

5.35e-03114583IPR005821
DomainIon_trans

TRPM3 CNGB1 RYR2

5.35e-03114583PF00520
DomainSmall_GTPase_Ras

NKIRAS1 GEM

5.89e-0337582IPR020849
Pubmed

Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity.

PFKFB1 PFKFB2

2.93e-06260215331593
Pubmed

Inhibitory effects on L- and N-type calcium channels by a novel CaVβ1 variant identified in a patient with autism spectrum disorder.

CACNB1 GEM

2.93e-06260235122502
Pubmed

Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.

AKAP6 ARHGEF10L

2.93e-06260229979793
Pubmed

Molecular cloning and tissue-specific expression of mouse kidney 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

PFKFB1 PFKFB2

2.93e-0626028814283
Pubmed

Structure-function studies of the G-domain from human gem, a novel small G-protein.

CACNB1 GEM

2.93e-06260217052716
Pubmed

Ephrin-A1 is up-regulated by hypoxia in cancer cells and promotes angiogenesis of HUVECs through a coordinated cross-talk with eNOS.

EFNA1 NOS3

2.93e-06260224040255
Pubmed

Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers.

AKAP6 RYR2

2.93e-06260211352932
Pubmed

Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes.

NOS3 RYR2

8.77e-06360218077344
Pubmed

High blood sugar levels significantly impact the prognosis of colorectal cancer patients through down-regulation of microRNA-16 by targeting Myb and VEGFR2.

GDE1 MYB

8.77e-06360226934556
Pubmed

Vitamin A regulates genes involved in hepatic gluconeogenesis in mice: phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphatase and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

PFKFB1 PFKFB2

8.77e-0636029202079
Pubmed

C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters.

CEBPE MYB

8.77e-06360210233885
Pubmed

Neogenin pathway positively regulates fibronectin production by glomerular mesangial cells.

NEO1 NOS3

8.77e-06360235704698
Pubmed

Expression of human placental-type 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase in various cells and cell lines.

PFKFB1 PFKFB2

1.75e-0546029464277
Pubmed

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme.

PFKFB1 PFKFB2

1.75e-0546027574501
Pubmed

Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner.

PFKFB1 PFKFB2

1.75e-05460211522786
Pubmed

Muscarinic-dependent phosphorylation of the cardiac ryanodine receptor by protein kinase G is mediated by PI3K-AKT-nNOS signaling.

NOS3 RYR2

1.75e-05460232580946
Pubmed

Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.

PFKFB1 PFKFB2

1.75e-05460210095107
Pubmed

Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase.

PFKFB1 PFKFB2

1.75e-0546022837207
Pubmed

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

FRAS1 ACAN WRN CPLANE1

2.77e-0510060425807483
Pubmed

Disturbed nitric oxide signalling gives rise to congenital bicuspid aortic valve and aortopathy.

FBLN5 NOS3

2.92e-05560232801116
Pubmed

Coagulation Factor Xa and Protease-Activated Receptor 2 as Novel Therapeutic Targets for Diabetic Nephropathy.

NOS3 F10

2.92e-05560227283743
Pubmed

Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.

AKAP6 RYR2

4.37e-05660223540699
Pubmed

Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage.

ACAN CHSY3

6.11e-05760217145758
Pubmed

The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate.

PFKFB1 PFKFB2

6.11e-05760215896703
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

U2AF1 MAP1B TSR1 SMC4 CCT8 ALDH18A1 ALPK2 LRRFIP1

7.28e-0580960832129710
Pubmed

Identification of 14-3-3epsilon substrates from embryonic murine brain.

CACNB1 MAP1B SRGAP2 DCX

8.20e-0513260416944949
Pubmed

Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction.

ADGRV1 DCX

1.05e-04960228705869
Pubmed

Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice.

PFKFB1 PFKFB2

1.05e-04960221074528
Pubmed

Structures and co-regulated expression of the genes encoding mouse cytosolic chaperonin CCT subunits.

CCT8 USP16

1.05e-04960210336634
Pubmed

SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart.

FBLN5 RYR2

1.31e-041060219386262
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

CACNB1 NEO1 MAP1B PCLO NUP88 FAM169A CCT8 RYR2 LRRFIP1

1.38e-04113960936417873
Pubmed

Nuclear export factor family protein participates in cytoplasmic mRNA trafficking.

U2AF1 MAP1B

1.59e-041160216014633
Pubmed

Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.

WRN RYR2

1.59e-041160217903301
Pubmed

Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia.

GCM1 NOS3

1.59e-041160218469803
Pubmed

The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21.

SMG1 MYB

1.91e-041260231732746
Pubmed

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

AKAP6 RYR2

1.91e-041260210830164
Pubmed

Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2.

ACAN CHSY3

1.91e-041260229287114
Pubmed

Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis.

ACAN CHSY3

1.91e-041260236047655
Pubmed

Loss of Dnmt3b accelerates MLL-AF9 leukemia progression.

CEBPE MYB

2.26e-041360227133822
Pubmed

Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin.

RBBP8 DCX

2.26e-041360222645310
Pubmed

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

SMG1 TTC39B U2AF1 TSR1 FAM169A SMC4 CCT8 AQR

2.54e-0497160833306668
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

CACNB1 FRAS1 MAP1B ACAN PFKFB2 ALPK2

2.55e-0451360625798074
Pubmed

Ischemic stroke is associated with the ABO locus: the EuroCLOT study.

CFH F10

2.63e-041460223381943
Pubmed

Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss.

CFH FBLN5

2.63e-041460219015224
Pubmed

Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons.

MAP1B GEM

2.63e-041460223106268
Pubmed

Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA.

SMC4 CCT8

2.63e-041460220585571
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

AKAP6 SMG1 SZT2 TSR1 ADGRV1 ARHGEF10L

3.01e-0452960614621295
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

AKAP6 CFH U2AF1 TARS3 EFNA1 ZBTB43 SRGAP2 USP16 LRRFIP1

3.38e-04128560935914814
Pubmed

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

MAP1B SMC4 CCT8 ALDH18A1 PFKFB2 AQR

3.73e-0455160634728620
Pubmed

The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.

U2AF1 CCT8 ALDH18A1 USP16

4.26e-0420360435012549
Pubmed

Mapping differentiation kinetics in the mouse retina reveals an extensive period of cell cycle protein expression in post-mitotic newborn neurons.

MAP1B DCX

4.40e-041860222837015
Pubmed

Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex.

MAP1B DCX

4.40e-041860222090513
Pubmed

Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities.

FRAS1 SRGAP2

4.40e-041860220602751
Pubmed

Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.

CFH ADGRV1 CNGB1

4.67e-048760320801516
Pubmed

Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.

RBBP8 WRN

4.91e-041960214578343
Pubmed

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.

FBLN5 RBBP8 ACAN

5.32e-049160320546612
Pubmed

QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function.

CACNB1 RYR2

5.45e-042060233397958
Pubmed

ETAA1 acts at stalled replication forks to maintain genome integrity.

WRN FANCM

6.02e-042160227723720
Pubmed

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.

MAP1B CCT8 LRRFIP1 MYB

6.37e-0422660431452512
Pubmed

Glucocorticoid receptor is required for foetal heart maturation.

PFKFB2 RYR2

6.61e-042260223595884
Pubmed

AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene.

CSF1 MYB

6.61e-04226029811459
Pubmed

Integrative predictive model of coronary artery calcification in atherosclerosis.

CFH FBLN5 WRN NOS3

6.69e-0422960419948975
Pubmed

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

TRPM3 FANCM ARHGEF10L

7.21e-0410160310997877
Pubmed

Proteomics characterization of extracellular space components in the human aorta.

FBLN5 SBSPON ACAN

7.21e-0410160320551380
Pubmed

Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis.

ACAN MYB

7.23e-042360223322385
Pubmed

Klf14 is an imprinted transcription factor that regulates placental growth.

FBLN5 GCM1

7.23e-042360231675530
Pubmed

Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism.

MAP1B PFKFB2

7.88e-042460225505152
Pubmed

Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.

CSF1 NOS3

8.56e-042560217355643
Pubmed

Substrate specificities and identification of putative substrates of ATM kinase family members.

RBBP8 WRN

8.56e-042560210608806
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

CFH FBLN5 CSF1 ACAN

9.00e-0424860424006456
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MAP1B TSR1 NUP88 SMC4 ALDH18A1 AQR

9.07e-0465360622586326
Pubmed

Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.

ACAN CHSY3

9.26e-042660233905568
Pubmed

Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.

MAP1B DCX

9.26e-042660217875933
Pubmed

Genetic loci influencing natural variations in femoral bone morphometry in mice.

CSF1 ACAN

9.99e-042760211518254
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

CFH FRAS1 FBLN5 MAP1B CCT8 CHSY3 GDE1 LRRFIP1

1.03e-03120160835696571
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

MAP1B NUP88 FAM169A CCT8 SRGAP2 PRR14L USP16

1.10e-0393460733916271
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

MAP1B TRPM3 ZBTB43 ZNF483 SRGAP2 LRRFIP1

1.19e-0368960636543142
Pubmed

Insights into the ubiquitin-proteasome system of human embryonic stem cells.

U2AF1 SRGAP2 AQR LRRFIP1

1.21e-0326960429511261
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

NUP88 CCT8 RYR2

1.28e-0312360326912792
Pubmed

HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA.

WRN USP16

1.32e-033160230279242
Pubmed

Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.

RBBP8 FANCM

1.32e-033160219690177
Pubmed

POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.

PCLO VSIG4 CCT8 PFKFB2

1.35e-0327760430745168
Pubmed

Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.

NKIRAS1 USP16 NOS3

1.37e-0312660324319055
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

U2AF1 TSR1 SMC4 CCT8 ALDH18A1 USP16 AQR LRRFIP1

1.37e-03125760836526897
Pubmed

LINKIN, a new transmembrane protein necessary for cell adhesion.

U2AF1 MAP1B TSR1 RBBP8 CCT8

1.44e-0348060525437307
Pubmed

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.

TRPM3 ZNF483

1.58e-033460223449627
Pubmed

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

FBLN5 RBBP8 ACAN

1.70e-0313660325429064
InteractionC2CD4B interactions

FRAS1 ALDH18A1 ADGRV1 ALPK2

8.81e-0644604int:C2CD4B
Cytoband5q13

MAP1B ADGRV1

3.82e-04226025q13
GeneFamily6-phosphofructo-2-kinases/fructose-2,6-biphosphatases

PFKFB1 PFKFB2

3.15e-0544221077
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#1_top-relative-expression-ranked_500

SMG1 MAP1B NRK WRN SMC4 CPLANE1 RYR2

3.47e-06231597gudmap_developingLowerUrinaryTract_e14.5_ bladder_500_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_k-means-cluster#5_top-relative-expression-ranked_1000

MAP1B NRK WRN SMC4 CPLANE1 RYR2

9.94e-06178596DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_k5_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#5_top-relative-expression-ranked_1000

SMG1 MAP1B NRK WRN SMC4 SRGAP2 CPLANE1 RYR2

1.34e-05397598gudmap_developingLowerUrinaryTract_e14.5_ bladder_1000_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_top-relative-expression-ranked_500

SMG1 MAP1B NRK WRN SMC4 CHSY3 CPLANE1 RYR2

2.05e-05421598gudmap_developingLowerUrinaryTract_e14.5_ bladder_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_500

AKAP6 MAP1B NRK WRN CHSY3 CPLANE1 DCX RYR2

2.26e-05427598DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#5_top-relative-expression-ranked_200

MAP1B NRK CPLANE1 RYR2

6.58e-0578594gudmap_developingLowerUrinaryTract_e14.5_ bladder_200_k5
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000

TTC39B FBLN5 MAP1B RBBP8 NRK PCLO FAM169A SMC4 ADGRV1 FANCM DCX

7.19e-059835911Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_top-relative-expression-ranked_1000

SMG1 MAP1B NRK WRN SMC4 CHSY3 SRGAP2 CPLANE1 GEM RYR2

7.19e-058115910gudmap_developingLowerUrinaryTract_e14.5_ bladder_1000
CoexpressionAtlasdev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_1000

TTC39B TSR1 NRK ZBTB43 NUP88 FAM169A PFKFB1 FANCM CPLANE1 MYB

8.04e-058225910gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_top-relative-expression-ranked_100

MAP1B NRK CHSY3 RYR2

8.39e-0583594gudmap_developingLowerUrinaryTract_e14.5_ bladder_100
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#5_top-relative-expression-ranked_500

MAP1B NRK WRN CPLANE1 RYR2

9.51e-05165595DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k5_500
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3

MAP1B TSR1 RBBP8 PCLO FAM169A SMC4 FANCM USP16

1.06e-04532598Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_top-relative-expression-ranked_200

MAP1B NRK CHSY3 CPLANE1 RYR2

1.13e-04171595gudmap_developingLowerUrinaryTract_e14.5_ bladder_200
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#3_top-relative-expression-ranked_100

MAP1B NRK RYR2

1.15e-0434593gudmap_developingLowerUrinaryTract_e14.5_ bladder_100_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_k-means-cluster#4_top-relative-expression-ranked_500

MAP1B NRK WRN RYR2

1.25e-0492594DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_k4_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_200

MAP1B NRK CHSY3 CPLANE1 DCX

1.36e-04178595DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_200
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder epithelial cells_emap-30875_k-means-cluster#1_top-relative-expression-ranked_200

MAP1B CHSY3

1.58e-047592gudmap_developingLowerUrinaryTract_e13.5_bladder epithelial cells_200_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#2_top-relative-expression-ranked_1000

SMG1 MAP1B NRK SRGAP2 CPLANE1 DCX

2.25e-04312596gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000_k2
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_1000_k-means-cluster#5

MAP1B PCLO FAM169A SMC4 FANCM

2.56e-04204595Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_1000_K5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#2_top-relative-expression-ranked_1000

SMG1 MAP1B NRK WRN CPLANE1 RYR2

3.03e-04330596DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k2_1000
CoexpressionAtlasdev gonad_e11.5_F_PrimGermCell_Oct_top-relative-expression-ranked_1000

TTC39B TSR1 NRK ZBTB43 NUP88 FAM169A PFKFB1 AQR MYB

3.36e-04799599gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_1000
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_500_k-means-cluster#4

MAP1B FAM169A SMC4 FANCM

3.93e-04124594Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_500_K4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_1000

AKAP6 SMG1 MAP1B NRK WRN CHSY3 CPLANE1 DCX RYR2

3.99e-04818599DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_1000
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000

SMG1 TTC39B TARS3 RBBP8 ZNF483 NUP88 FAM169A PFKFB1 CPLANE1

4.06e-04820599gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_top-relative-expression-ranked_1000

MAP1B NRK WRN SMC4 CHSY3 CPLANE1 GEM MAP4K2 RYR2

4.28e-04826599DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_1000
CoexpressionAtlasdev lower uro neuro_e15.5_BladdPelvicGanglion_Sox10_k-means-cluster#2_top-relative-expression-ranked_500

MAP1B NRK PCLO DCX

4.57e-04129594gudmap_dev lower uro neuro_e15.5_BladdPelvicGanglion_Sox10_k2_500
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#2_top-relative-expression-ranked_1000

CFH TTC39B FBLN5 ADGRV1 MAP4K2

4.80e-04234595gudmap_developingKidney_e15.5_Peripheral blastema_1000_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#1_top-relative-expression-ranked_200

MAP1B NRK CPLANE1

6.54e-0461593DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k1_200
CoexpressionAtlasdev lower uro neuro_e15.5_BladdPelvicGanglion_Sox10_k-means-cluster#4_top-relative-expression-ranked_200

MAP1B NRK DCX

6.86e-0462593gudmap_dev lower uro neuro_e15.5_BladdPelvicGanglion_Sox10_k4_200
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 TRPM3 NRK PCLO ADGRV1 DCX RYR2

4.86e-091845972cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 TRPM3 NRK PCLO ADGRV1 DCX RYR2

4.86e-09184597ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 TRPM3 NRK PCLO ADGRV1 DCX RYR2

4.86e-091845972b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 MAP1B SBSPON GEM RYR2 ARHGEF10L

2.43e-07197596bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 MAP1B PCLO ADGRV1 DCX CNGB1

2.57e-0719959647466253069d4b1b8f13ce3210f434e60753b38a
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFH FBLN5 MAP1B CHSY3 GEM RYR2

2.65e-0720059658b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

CFH FRAS1 TRPM3 SBSPON ALPK2

2.91e-06168595a086c306be430adf0632ba53e98cd8014d2de330
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH FBLN5 MAP1B CHSY3 GEM

3.26e-061725951ef243bce63d841c25e4b74d029d1377f84bcc3d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH FBLN5 MAP1B CHSY3 GEM

3.26e-06172595ab1c81be29f93ca8920c6ab5ab92f497a9256d3f
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th|T/NK_cells / Location, Cell class and cell subclass

VSIG4 ADGRV1 NKIRAS1 NOS3 GDE1

3.36e-0617359542c911ed16fabdabef063830e8407192d8bde950
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

AKAP6 MAP1B SBSPON GEM RYR2

3.36e-06173595a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 TRPM3 PCLO PFKFB2 USP16

3.45e-06174595f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 NRK FAM169A ADGRV1 ARHGEF10L

4.19e-061815959d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 NRK FAM169A ADGRV1 ARHGEF10L

4.30e-06182595eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AKAP6 MAP1B ACAN GEM RYR2

4.78e-061865954780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AKAP6 MAP1B ACAN GEM RYR2

4.78e-06186595a95744b8649096bd7cfc3591a02841fa411085b3
ToppCell3'-Adult-LargeIntestine-Mesenchymal-stromal_related-T_reticular|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH FBLN5 CSF1 GEM F10

4.91e-06187595f0c4d93f75615e570e4465fd622e3124189618a1
ToppCell3'-Adult-LargeIntestine-Mesenchymal-stromal_related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH FBLN5 CSF1 GEM F10

4.91e-061875953ff57da09ed8394913fb683669d7bff84a936623
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FBLN5 ACAN NRK DCX F10

5.17e-06189595eccf3d49354a67c94f1ed7c15a98a48a5e8e2ed0
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

AKAP6 SBSPON CHSY3 GEM ARHGEF10L

5.17e-061895956b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B ACAN CHSY3 GEM RYR2

5.17e-06189595fac5c291a9a87418bb0878c3d624829bdbf1f428
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FBLN5 ACAN NRK DCX F10

5.17e-0618959540764f461b8aa1d3a2c5a30590b7fb9307d47d09
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN5 CSF1 MAP1B CHSY3 GEM

5.30e-061905951121eb607a984c59fbffe7220837fc178745aa55
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN5 CSF1 MAP1B CHSY3 GEM

5.30e-06190595048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B ACAN CHSY3 GEM RYR2

5.44e-0619159504c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FBLN5 MAP1B SBSPON NRK F10

5.58e-061925954ed5040594ba2d0639f0990697504ecef872ca70
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FBLN5 MAP1B SBSPON NRK F10

5.58e-06192595d4f5d6653564c2c5d0f5f7c932d89cb1b1412844
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)|368C / Donor, Lineage, Cell class and subclass (all cells)

AKAP6 MAP1B SBSPON ACAN GEM

5.72e-061935955182284dfa7c94027e94172e08f78c86b95d63f4
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SMG1 TTC39B FRAS1 FAM169A GCM1

5.72e-061935959337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)-|368C / Donor, Lineage, Cell class and subclass (all cells)

AKAP6 MAP1B SBSPON ACAN GEM

5.72e-061935954f7bab0115469c855160636d168bd6e5d4e2dd2f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 TRPM3 RBBP8 PCLO ARHGEF10L

5.87e-0619459593c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 MAP1B SBSPON ACAN RYR2

5.87e-061945955c3b2b05d1e4f146551fe4c920263d8e6ca34de3
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 MAP1B SBSPON ACAN RYR2

5.87e-06194595ab9cad697f9209d2889bc02b43b502dfeb2ebfef
ToppCellCOVID-19-lung-Pericytes/_Smooth_Muscle|lung / Disease (COVID-19 only), tissue and cell type

AKAP6 MAP1B ACAN GEM RYR2

5.87e-061945955e1e0513a54ec4cf0b247ec85c9fbc68dfac1da3
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH FBLN5 MAP1B GEM F10

6.01e-061955951236dc60288c7dd91868e86e9174a2dacd3b11b3
ToppCellIPF-Stromal-Myofibroblast|World / Disease state, Lineage and Cell class

CFH FBLN5 MAP1B GEM RYR2

6.17e-061965957fc9894ceb79dab9f0495acc84e2d6d0d1c69bb7
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 MAP1B SBSPON GEM RYR2

6.17e-061965959830fb3da7a60f65ad463e9054bb77c06b025e4d
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 MAP1B PCLO DCX CNGB1

6.32e-06197595b9478212f14b7888e3abac02995177974ac3bd17
ToppCellCOPD-Stromal|COPD / Disease state, Lineage and Cell class

CFH FBLN5 MAP1B GEM F10

6.32e-06197595d5390d86acaa8c39f1da893e8d2271f9ed2951d7
ToppCellBronchial-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MAP1B SBSPON ACAN GEM RYR2

6.32e-06197595d1cb30ec4f3024541e9876c70bf63fe4d5c55bf1
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 MAP1B SBSPON GEM RYR2

6.32e-06197595ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCelldistal-3-mesenchymal-Fibromyocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFH MAP1B SBSPON GEM F10

6.48e-06198595dc93886439a378a0c71e99acb8081bfb6b6d467b
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 MAP1B GEM RYR2 ARHGEF10L

6.48e-06198595bd42c03e384e64f61b02618cf1a5440033bb04b2
ToppCelldistal-mesenchymal-Fibromyocyte-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFH FBLN5 SBSPON GEM F10

6.48e-061985959d1d95e7703cfc70a8ad427e400c340dbd205db8
ToppCellCOVID-19-lung-Fibroblast|lung / Disease (COVID-19 only), tissue and cell type

CFH FRAS1 FBLN5 GEM RYR2

6.48e-06198595df3de77216f5c5d6141ec44d01c56b942f611838
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 MAP1B SBSPON GEM RYR2

6.48e-06198595c12e7511628db819a52959bb68580e27c00c2e41
ToppCelldistal-1-mesenchymal-Alveolar_Fibroblast|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFH FBLN5 GEM F10 RYR2

6.48e-061985956594c35ab203dc51462167c61807b0d49fa30fb2
ToppCellIPF-Stromal|IPF / Disease state, Lineage and Cell class

CFH FBLN5 MAP1B GEM RYR2

6.48e-06198595ece914c32c9b123b779aa9624b92e6230763a20e
ToppCellCOPD-Stromal-Fibroblast|COPD / Disease state, Lineage and Cell class

CFH FBLN5 MAP1B GEM F10

6.48e-061985957904af61473cb20064f7a3a1e1bfe8d5913cf317
ToppCelldistal-mesenchymal-Fibromyocyte|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFH FBLN5 SBSPON GEM F10

6.48e-06198595fbfac1d10e4224990a094cc84b74bbc206881423
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 MAP1B GEM RYR2 ARHGEF10L

6.64e-06199595b1753474152b82a0b811b9878c890a359e14919a
ToppCelldistal-mesenchymal|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFH FBLN5 MAP1B GEM F10

6.80e-06200595b54137a4545690f51e154bb05964eaa650c3ca8e
ToppCellBronchial-10x5prime-Stromal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFH FBLN5 MAP1B GEM F10

6.80e-062005955ea12e17f50fefbf5534e487af3392b2fa2d13ad
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 MAP1B SBSPON GEM RYR2

6.80e-06200595a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

CFH FRAS1 FBLN5 GEM RYR2

6.80e-06200595aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCellParenchymal-10x5prime-Stromal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFH FBLN5 MAP1B GEM F10

6.80e-062005952e525c0d9684e7a2275edb04e1addb6fc6a872e5
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CFH FRAS1 FBLN5 GEM RYR2

6.80e-06200595a510deaada669e690329183e18df02870bd204b3
ToppCelldistal-3-mesenchymal|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFH FBLN5 MAP1B GEM F10

6.80e-062005957a79a2de78325d4f1c4535969106a0a44249028c
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer|World / Primary Cells by Cluster

NEO1 MAP1B PCLO DCX RYR2

6.80e-06200595db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21|World / Primary Cells by Cluster

NEO1 MAP1B PCLO DCX RYR2

6.80e-0620059530a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCellBronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFH MAP1B ACAN NRK DCX

6.80e-0620059529054cf55e88e1ac81a562d8dd9af9b7c749321d
ToppCellBiopsy_Other_PF-Mesenchymal|Biopsy_Other_PF / Sample group, Lineage and Cell type

CFH FBLN5 MAP1B GEM F10

6.80e-06200595d6fcdd48858b53b5a8d18ae14b2dc4d9af41b070
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFH FRAS1 FBLN5 GEM RYR2

6.80e-06200595dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCellLPS-IL1RA-Endothelial-Epi-like|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB1 ACAN PCLO PFKFB2

1.71e-05116594cf4e3c34570f57502ec524881d351ef8e47976d2
ToppCellRV-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

AKAP6 GCM1 ALPK2 RYR2

2.09e-051225941cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-7|TCGA-Stomach / Sample_Type by Project: Shred V9

AKAP6 SBSPON ZNF483 RYR2

2.44e-051275945e4d110cc6e68cd8fc7a4771a65e6f8cd83e7721
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c13-HAVCR2|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SMC4 GEM MAP4K2 MYB

3.10e-05135594641d42a005ff61f21e6cda02bfbd0bd1d4ba2faa
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

AKAP6 SBSPON GEM F10

6.02e-05160594d783d29150033e9181c0e30870070268fed3fd85
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

SZT2 SRGAP2 GEM F10

6.47e-051635949f5facfa1864eb63e2f8022ad7379d9252b7a254
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 TRPM3 PFKFB1 ARHGEF10L

6.63e-051645946fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN5 EFNA1 FAM169A NOS3

6.94e-051665947a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNB1 MAP1B SBSPON RYR2

6.94e-0516659426f3d5e5e30b63b09b89cda23c423d12d887631f
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN5 EFNA1 FAM169A NOS3

6.94e-05166594bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH FBLN5 MAP1B CHSY3

7.27e-05168594d19a115365c5415e51c039718d7669de788fcf33
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 PCLO ADGRV1 RYR2

7.44e-0516959412bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CSF1 MAP1B ACAN GEM

7.61e-05170594d9ed257d0938442d0bb280e4c4b0c9b657511b46
ToppCellfacs-Marrow-T-cells-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH SRGAP2 F10 ARHGEF10L

7.61e-05170594a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCellfacs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH SRGAP2 F10 ARHGEF10L

7.61e-05170594ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCellwk_20-22-Mesenchymal-Chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CFH ACAN NRK DCX

7.79e-05171594d2938639e9a7c349e5a6ec61724222f9d127c89f
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ACAN GEM RYR2 ARHGEF10L

7.79e-051715944ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

AKAP6 MAP1B RYR2 ARHGEF10L

8.15e-05173594cb6389536195443633adb06e5f1b7483530773d1
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SBSPON IL20RA ARHGEF10L MYB

8.33e-05174594a9f34d1237f335d27c5560ff514368f4709f9144
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 SBSPON IL20RA MYB

8.33e-051745940fccd90ef72ec2e5eb369fe6d6d126c60886485a
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 ADGRV1 DCX CNGB1

8.33e-05174594271c51d220842402975d97c86c9acfdbdf62a32c
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 SBSPON IL20RA MYB

8.33e-05174594b2fc2a756f8e373ad903bd416d9de703d945fa1c
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SBSPON IL20RA ARHGEF10L MYB

8.71e-05176594d43d9e86c4d4fa1e88fbf2b899ac7143717aac90
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|356C / Donor, Lineage, Cell class and subclass (all cells)

CFH MAP1B F10 RYR2

8.90e-05177594cdfd2f0ee2f692271b1525e414b0f645cdadb1f6
ToppCelldroplet-Spleen-nan-24m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH CNGB1 F10 ARHGEF10L

8.90e-051775945f20a1a875d6f85ec07b097e6afdb07c2f8f88ff
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)|356C / Donor, Lineage, Cell class and subclass (all cells)

CFH MAP1B F10 RYR2

8.90e-05177594db222faaecbe5600da39277243c4e7e764eb63c9
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 TRPM3 PCLO PFKFB2

9.10e-05178594fcbbcc44271515de1969b4732b6441c012693d5f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH FBLN5 MAP1B GEM

9.10e-05178594d4ecb84e9b1f4ec49c519321156aa10f9bd34cce
ToppCelldroplet-Kidney-KIDNEY-1m-Lymphocytic-CD45____B_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALDH18A1 PRR14L GEM RYR2

9.29e-0517959469c74b2ff43b43653005807654953daf21f932ec
ToppCellCOVID-19-kidney-vSMC/Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 SBSPON ACAN GEM

9.29e-05179594111b1084f73306bdeffaaf240e7dbb4f5bf33de1
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

FRAS1 EFNA1 CHSY3 ADGRV1

9.29e-05179594cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN5 EFNA1 MAP1B NOS3

9.50e-0518059467c5068b660cd5e727a665cefe3bd5f8ae887221
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN5 EFNA1 MAP1B NOS3

9.70e-051815944d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAP1B PCLO DCX CNGB1

9.70e-05181594fb4df9a128761abe5c6310a30d7b2f7f2fdef46d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH FBLN5 MAP1B GEM

9.70e-05181594c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 MAP1B TRPM3 ACAN

9.70e-05181594098dbb3e0ff531c9720a233123250c1e39a97d4c
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAP1B PCLO DCX CNGB1

9.70e-051815947f99002a6411117cc2361334c7c9228e20c574b4
DrugBeta-Escin [11072-93-8]; Up 200; 3.2uM; PC3; HT_HG-U133A

EFNA1 CSF1 ZBTB43 PFKFB2 DCX GEM

5.89e-061745964544_UP
DrugMethyl benzethonium chloride [25155-18-4]; Up 200; 8.6uM; MCF7; HT_HG-U133A

CACNB1 SZT2 PCLO ZBTB43 FAM169A GEM

1.06e-051935963850_UP
DrugAnabasine [494-52-0]; Up 200; 24.6uM; MCF7; HT_HG-U133A

CACNB1 CSF1 CEBPE TRPM3 ACAN PFKFB2

1.13e-051955966074_UP
Drugbrazilin

PFKFB1 PFKFB2 NOS3

1.31e-0518593CID000073384
Diseasediastolic blood pressure, systolic blood pressure

FBLN5 EFNA1 CSF1 MAP1B TRPM3 ACAN MAP4K2 RYR2 LRRFIP1

6.00e-06670589EFO_0006335, EFO_0006336
DiseaseCutis Laxa, Autosomal Dominant

FBLN5 ALDH18A1

1.14e-053582C0268350
DiseaseCutis laxa, autosomal dominant

FBLN5 ALDH18A1

1.14e-053582cv:C0268350
DiseaseCutis laxa, autosomal recessive

FBLN5 ALDH18A1

3.78e-055582cv:C3665335
DiseaseTachycardia, Ventricular

NOS3 RYR2

2.06e-0411582C0042514
Diseasecomplement factor H measurement, protein binding measurement

CFH LRRFIP1

3.40e-0414582EFO_0008097, EFO_0010742
Diseasecomplement factor H-related protein 3 measurement

AKAP6 CFH ACAN ADGRV1

3.46e-04169584EFO_0600056
Diseasedual specificity mitogen-activated protein kinase kinase 2 measurement

CFH F10

4.48e-0416582EFO_0008112
Diseasehypothyroidism (biomarker_via_orthology)

MAP1B DCX NOS3

5.32e-0480583DOID:1459 (biomarker_via_orthology)
DiseaseAge-related macular degeneration

CFH FBLN5

5.69e-0418582cv:C0242383
Diseaseexercise test

WRN RYR2

7.05e-0420582EFO_0004328
Diseasecoagulation factor measurement

CFH F10

7.05e-0420582EFO_0004634
DiseaseInfiltrating duct carcinoma of female breast

SMG1 NRK

7.78e-0421582C3165106
DiseaseDisorder of eye

FRAS1 ADGRV1 CPLANE1 CNGB1

8.11e-04212584C0015397
Diseasecataract (is_implicated_in)

TRPM3 ALDH18A1

1.20e-0326582DOID:83 (is_implicated_in)
DiseaseL lactate dehydrogenase measurement

CFH CSF1

1.20e-0326582EFO_0004808
Diseaselissencephaly (implicated_via_orthology)

DCX NOS3

1.29e-0327582DOID:0050453 (implicated_via_orthology)
Diseaseretinal degeneration (biomarker_via_orthology)

CFH NOS3

1.39e-0328582DOID:8466 (biomarker_via_orthology)
DiseaseMiller Dieker syndrome

FANCM DCX

1.49e-0329582C0265219
DiseaseAge related macular degeneration

CFH FBLN5

1.59e-0330582C0242383

Protein segments in the cluster

PeptideGeneStartEntry
AGVCEEMTYEEIQEH

PFKFB1

331

P16118
EIDAGVCEEMTYAEI

PFKFB2

326

O60825
LEHSEEDGSIYEMAD

ARHGEF10L

1201

Q9HCE6
DMFDRTTHEEYESCL

RBBP8

726

Q99708
AYTELGDSCVDMETD

CACNB1

511

Q02641
GDMCEHEASIDLSAY

CEBPE

31

Q15744
LLESDDEEMEFGEHC

ALPK2

356

Q86TB3
VEETADYVECACSHM

ADGRV1

5876

Q8WXG9
SYEEDMEIAEGCFRH

AQR

986

O60306
GYKIEGDEEMHCSDD

CFH

181

P08603
ESCEVALDMYEHETG

DOHH

271

Q9BU89
SMDSDCEVLGEDTYE

GEM

101

P55040
DCELETYDMFPDTIH

MAP4K2

301

Q12851
CTVYIHDDSMFEPEE

FRAS1

2986

Q86XX4
EGVAEDTYSHMEGVA

MAP1B

1536

P46821
YGNHTIGMEDCETME

NKIRAS1

26

Q9NYS0
EGMRHEEGECSYELE

FANCM

766

Q8IYD8
IHFVDGDIMEEYSTE

FAM177B

26

A6PVY3
AEMEELHRSSCSEYS

PCLO

1846

Q9Y6V0
DEDFEMCDHDYDGLL

MYB

16

P10242
GYASHLMEIFCDSEE

IL20RA

361

Q9UHF4
EGICHMYVDSEASVD

ALDH18A1

581

P54886
YRCEVMHGIEDSEAT

ACAN

131

P16112
LCMDEYDVVSLEHET

NOS3

551

P29474
ETEGLHCEYAAEPVM

ERVK-21

126

P62683
SSYITDSMVEDCEPH

GDE1

316

Q9NZC3
ITEEVSEYCSHMIGS

CSF1

31

P09603
MHISDYEEDIEESVG

CPLANE1

1906

Q9H799
CPHYEDHSVADAAME

EFNA1

51

P20827
MDELEEGESYVCSSD

DCX

116

O43602
DFEEEMTYLGLDHCN

GCM1

411

Q9NP62
CSHEELENSAEDYMS

FAM169A

11

Q9Y6X4
YELEEDGVHCSDMDE

FBLN5

236

Q9UBX5
GHLERECMEETCSYE

F10

51

P00742
YADIMAKSCHDEEDD

RYR2

3691

Q92736
SDDTVYHDDKCMVEV

LRRFIP1

446

Q32MZ4
DESTEGMVDIVYTDC

PRR14L

1046

Q5THK1
GMLYHCVVLEGEEED

NUP88

331

Q99567
DGYHLIDAESEVMSD

NRK

1431

Q7Z2Y5
FEEGFMADVDLDHSC

TARS3

721

A2RTX5
VTMEGGYDILHDVSC

SZT2

461

Q5T011
EDMEAYAEDLSHVAS

SMG1

366

Q96Q15
YAHESMDIVFECEVT

NEO1

351

Q92859
SRLDHCYSMDDSEDT

WRN

941

Q14191
TDDEIYEDCTLMSGL

AKAP6

1781

Q13023
ECLREMYTTHEDVEV

CHSY3

331

Q70JA7
AEAEPVEEEHYCDML

CNGB1

616

Q14028
LEQACEGMDVHATYD

ZBTB43

251

O43298
DCESVNEGKMHEEAY

ZNF99

116

A8MXY4
EEEEYETMTIGESVH

TSR1

441

Q2NL82
ETMTIGESVHDDLYD

TSR1

446

Q2NL82
EQLSEEEMHAEICYA

TTC39B

226

Q5VTQ0
CTIDHPEDSEYEAEM

USP16

471

Q9Y5T5
THTEDAGYCMEFKTE

SBSPON

161

Q8IVN8
DIYVSAMDELHCDID

TRPM3

1426

Q9HCF6
MEDYCDSPHGETTSV

SRGAP2

696

O75044
HDEGMLEYLEDIIGC

SMC4

246

Q9NTJ3
RCAVSDVEMQEHYDE

U2AF1

66

Q01081
STLEMDDRSHYTCEV

VSIG4

101

Q9Y279
MEESQQYCGSSEEDH

ZNF483

261

Q8TF39
LEEMGHCDSVYLSEV

CCT8

341

P50990