Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	peptidyl-dipeptidase activity	ACE2 ACE	6.10e-06	3	29	2	GO:0008241
GeneOntologyBiologicalProcess	angiotensin maturation	ACE2 ACE	6.36e-05	9	28	2	GO:0002003
GeneOntologyBiologicalProcess	regulation of gap junction assembly	ACE2 ACE	7.94e-05	10	28	2	GO:1903596
GeneOntologyBiologicalProcess	regulation of angiotensin levels in blood	ACE2 ACE	9.70e-05	11	28	2	GO:0002002
GeneOntologyBiologicalProcess	regulation of blood volume by renin-angiotensin	ACE2 ACE	1.60e-04	14	28	2	GO:0002016
GeneOntologyBiologicalProcess	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	TNRC6C TNRC6A	1.60e-04	14	28	2	GO:0060213
GeneOntologyBiologicalProcess	regulation of nuclear-transcribed mRNA poly(A) tail shortening	TNRC6C TNRC6A	2.11e-04	16	28	2	GO:0060211
GeneOntologyBiologicalProcess	gap junction assembly	ACE2 ACE	3.00e-04	19	28	2	GO:0016264
HumanPheno	Myoclonic tremor	RAPGEF2 TNRC6A	2.78e-06	2	9	2	HP:0033054
HumanPheno	Cortical myoclonus	RAPGEF2 TNRC6A	2.77e-05	5	9	2	HP:0040148
MousePheno	increased angiotensin I-converting enzyme activity	ACE2 ACE	3.21e-05	6	21	2	MP:0003184
MousePheno	abnormal angiotensin I-converting enzyme activity	ACE2 ACE	3.21e-05	6	21	2	MP:0013254
MousePheno	abnormal circulating angiotensin II level	ACE2 ACE	1.41e-04	12	21	2	MP:0031230
MousePheno	abnormal angiotensin II level	ACE2 ACE	1.41e-04	12	21	2	MP:0031227
Domain	M_domain	TNRC6C TNRC6A	2.01e-06	2	27	2	PF12938
Domain	GW182_M_dom	TNRC6C TNRC6A	2.01e-06	2	27	2	IPR026805
Domain	Peptidase_M2	ACE2 ACE	2.01e-06	2	27	2	PF01401
Domain	Ago_hook	TNRC6C TNRC6A	6.03e-06	3	27	2	PF10427
Domain	TNRC6-PABC_bdg	TNRC6C TNRC6A	6.03e-06	3	27	2	PF16608
Domain	Peptidase_M2	ACE2 ACE	6.03e-06	3	27	2	IPR001548
Domain	TNRC6_PABC-bd	TNRC6C TNRC6A	6.03e-06	3	27	2	IPR032226
Domain	Argonaute_hook_dom	TNRC6C TNRC6A	6.03e-06	3	27	2	IPR019486
Domain	ZINC_PROTEASE	ACE2 ADAMTS5 ACE	3.74e-04	98	27	3	PS00142
Domain	UBA-like	TNRC6C TNRC6A	3.84e-03	64	27	2	IPR009060
Pathway	WP_SARSCOV2_AND_ACE2_RECEPTOR_MOLECULAR_MECHANISMS	ACE2 ACE	5.80e-05	7	24	2	M39867
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	TNRC6C TNRC6A	5.80e-05	7	24	2	M46421
Pathway	WP_NONCLASSICAL_ROLE_OF_VITAMIN_D	ACE2 ACE	7.73e-05	8	24	2	M42566
Pathway	REACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION	TNRC6C TNRC6A	9.93e-05	9	24	2	M27810
Pathway	REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION	TNRC6C TNRC6A	9.93e-05	9	24	2	M46436
Pathway	REACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS	PLD3 IGHV4-61 IGHV4-39	1.13e-04	56	24	3	MM14815
Pathway	REACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS	TNRC6C TNRC6A	1.24e-04	10	24	2	M48013
Pathway	BIOCARTA_ACE2_PATHWAY	ACE2 ACE	2.14e-04	13	24	2	MM1347
Pathway	BIOCARTA_ACE2_PATHWAY	ACE2 ACE	2.14e-04	13	24	2	M12950
Pathway	REACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION	TNRC6C TNRC6A	2.14e-04	13	24	2	M46434
Pathway	REACTOME_METABOLISM_OF_ANGIOTENSINOGEN_TO_ANGIOTENSINS	ACE2 ACE	2.88e-04	15	24	2	MM14797
Pathway	WP_ACE_INHIBITOR_PATHWAY	ACE2 ACE	3.72e-04	17	24	2	M39680
Pathway	REACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY	TNRC6C TNRC6A	3.72e-04	17	24	2	M27788
Pathway	KEGG_RENIN_ANGIOTENSIN_SYSTEM	ACE2 ACE	3.72e-04	17	24	2	M17636
Pathway	REACTOME_METABOLISM_OF_ANGIOTENSINOGEN_TO_ANGIOTENSINS	ACE2 ACE	3.72e-04	17	24	2	M27104
Pathway	REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS	TNRC6C TNRC6A	4.67e-04	19	24	2	M48238
Pathway	REACTOME_MITF_M_DEPENDENT_GENE_EXPRESSION	ATP6V0A1 TNRC6C TNRC6A	5.42e-04	95	24	3	M48268
Pathway	REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION	TNRC6C GP1BA TNRC6A	5.58e-04	96	24	3	M27792
Pathway	REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS	PLD3 IGHV4-61 IGHV4-39	9.21e-04	114	24	3	MM14814
Pathway	WP_SARSCOV2_MITOCHONDRIAL_CHRONIC_OXIDATIVE_STRESS_AND_ENDOTHELIAL_DYSFUNCTION	ACE2 ACE	9.50e-04	27	24	2	M45548
Pathway	REACTOME_TGFBR3_EXPRESSION	TNRC6C TNRC6A	1.02e-03	28	24	2	M48253
Pathway	WP_RAS_AND_BRADYKININ_PATHWAYS_IN_COVID19	ACE2 ACE	1.10e-03	29	24	2	M40051
Pathway	REACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION	TNRC6C TNRC6A	1.34e-03	32	24	2	M48012
Pathway	REACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY	TNRC6C TNRC6A	1.34e-03	32	24	2	M27900
Pathway	WP_MITOCHONDRIAL_IMMUNE_RESPONSE_TO_SARSCOV2	ACE2 ACE	1.42e-03	33	24	2	M40066
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4	TNRC6C TNRC6A	1.51e-03	34	24	2	M46422
Pathway	REACTOME_MITF_M_REGULATED_MELANOCYTE_DEVELOPMENT	ATP6V0A1 TNRC6C TNRC6A	1.57e-03	137	24	3	M48232
Pathway	REACTOME_CD22_MEDIATED_BCR_REGULATION	IGHV4-61 IGHV4-39	1.60e-03	35	24	2	MM17219
Pathway	REACTOME_ONCOGENE_INDUCED_SENESCENCE	TNRC6C TNRC6A	1.60e-03	35	24	2	M27190
Pathway	REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX	TNRC6C TNRC6A	1.78e-03	37	24	2	M29790
Pathway	REACTOME_CLASSICAL_ANTIBODY_MEDIATED_COMPLEMENT_ACTIVATION	IGHV4-61 IGHV4-39	1.98e-03	39	24	2	MM17212
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_VENTX	TNRC6C TNRC6A	2.19e-03	41	24	2	M29748
Pathway	REACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION	IGHV4-61 IGHV4-39	2.63e-03	45	24	2	MM14912
Pathway	REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING	TNRC6C TNRC6A	2.87e-03	47	24	2	M29777
Pathway	REACTOME_FCGR_ACTIVATION	IGHV4-61 IGHV4-39	2.99e-03	48	24	2	MM17214
Pathway	REACTOME_SIGNALING_BY_TGFBR3	TNRC6C TNRC6A	3.11e-03	49	24	2	M48250
Pubmed	Myocardial infarction increases ACE2 expression in rat and humans.	ACE2 ACE	7.69e-07	2	31	2	15671045
Pubmed	ACE and ACE2 Gene Variants Are Associated With Severe Outcomes of COVID-19 in Men.	ACE2 ACE	7.69e-07	2	31	2	35250987
Pubmed	Type 1 diabetes is associated with significant changes of ACE and ACE2 expression in peripheral blood mononuclear cells.	ACE2 ACE	7.69e-07	2	31	2	35260304
Pubmed	Angiotensin-converting enzyme genotype interacts with systolic blood pressure to determine coronary heart disease risk in healthy middle-aged men.	ACE LPL	7.69e-07	2	31	2	17562973
Pubmed	ACE2 gene expression is up-regulated in the human failing heart.	ACE2 ACE	7.69e-07	2	31	2	15151696
Pubmed	Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme.	ACE2 ACE	7.69e-07	2	31	2	12459472
Pubmed	Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells.	ACE2 ACE	7.69e-07	2	31	2	16166094
Pubmed	Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse.	ACE2 ACE	7.69e-07	2	31	2	28273875
Pubmed	Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections.	ACE2 ACE	7.69e-07	2	31	2	24800825
Pubmed	Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis.	ACE2 ACE	7.69e-07	2	31	2	19021774
Pubmed	Angiotensin converting enzyme insertion/deletion genetic polymorphism: its impact on renal function in critically ill patients.	ACE2 ACE	7.69e-07	2	31	2	19020433
Pubmed	The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases.	ACE2 ACE	7.69e-07	2	31	2	17504232
Pubmed	Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart.	ACE2 ACE	7.69e-07	2	31	2	18356559
Pubmed	Increased Angiotensin-Converting Enzyme 2 and Loss of Alveolar Type II Cells in COVID-19-related Acute Respiratory Distress Syndrome.	ACE2 ACE	7.69e-07	2	31	2	34449302
Pubmed	Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome.	ACE2 ACE	7.69e-07	2	31	2	32882331
Pubmed	The combination of ACE I/D and ACE2 G8790A polymorphisms revels susceptibility to hypertension: A genetic association study in Brazilian patients.	ACE2 ACE	7.69e-07	2	31	2	31430320
Pubmed	Kidney and Lung ACE2 Expression after an ACE Inhibitor or an Ang II Receptor Blocker: Implications for COVID-19.	ACE2 ACE	7.69e-07	2	31	2	32669323
Pubmed	Balance between angiotensin converting enzyme and angiotensin converting enzyme 2 in patients with chronic heart failure.	ACE2 ACE	7.69e-07	2	31	2	25869724
Pubmed	Angiotensin-converting enzyme 2 is an essential regulator of heart function.	ACE2 ACE	7.69e-07	2	31	2	12075344
Pubmed	Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women.	ACE2 ACE	7.69e-07	2	31	2	17473847
Pubmed	Synergistic expression of angiotensin-converting enzyme (ACE) and ACE2 in human renal tissue and confounding effects of hypertension on the ACE to ACE2 ratio.	ACE2 ACE	7.69e-07	2	31	2	17303661
Pubmed	Assessment of angiotensin converting enzyme gene polymorphism in preeclampsia mothers of Bangladesh.	ACE2 ACE	7.69e-07	2	31	2	33241696
Pubmed	Angiotensin-converting enzyme (ACE) and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis.	ACE2 ACE	7.69e-07	2	31	2	19136547
Pubmed	Genotype variation of ACE and ACE2 genes affects the severity of COVID-19 patients.	ACE2 ACE	7.69e-07	2	31	2	37667339
Pubmed	Levels of angiotensin-converting enzyme 1 and 2 in serum and urine of children with Sickle Cell Disease.	ACE2 ACE	7.69e-07	2	31	2	33973994
Pubmed	Albumin caused the increasing production of angiotensin II due to the dysregulation of ACE/ACE2 expression in HK2 cells.	ACE2 ACE	7.69e-07	2	31	2	19141296
Pubmed	Localization of ACE2 in the renal vasculature: amplification by angiotensin II type 1 receptor blockade using telmisartan.	ACE2 ACE	7.69e-07	2	31	2	19004932
Pubmed	Global distribution of ACE1 (rs4646994) and ACE2 (rs2285666) polymorphisms associated with COVID-19: A systematic review and meta-analysis.	ACE2 ACE	7.69e-07	2	31	2	36116608
Pubmed	Association investigations between ACE1 and ACE2 polymorphisms and severity of COVID-19 disease.	ACE2 ACE	7.69e-07	2	31	2	36255490
Pubmed	Urinary mRNA expression of ACE and ACE2 in human type 2 diabetic nephropathy.	ACE2 ACE	7.69e-07	2	31	2	18389211
Pubmed	Angiotensin-converting enzyme (ACE and ACE2) imbalance correlates with the severity of cerulein-induced acute pancreatitis in mice.	ACE2 ACE	7.69e-07	2	31	2	24414175
Pubmed	Angiotensin converting enzymes ACE and ACE2 in thyroid cancer progression.	ACE2 ACE	7.69e-07	2	31	2	31847529
Pubmed	Polymorphisms in the human angiotensin converting enzyme gene (ACE) linked to susceptibility of COVID-19 and malaria infections in the Ghanaian population.	ACE2 ACE	7.69e-07	2	31	2	38367677
Pubmed	Sex dimorphism in ANGII-mediated crosstalk between ACE2 and ACE in diabetic nephropathy.	ACE2 ACE	7.69e-07	2	31	2	29884907
Pubmed	No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension.	ACE2 ACE	7.69e-07	2	31	2	15233982
Pubmed	A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.	ACE2 ACE	7.69e-07	2	31	2	10924499
Pubmed	Discrepancy between intrarenal messenger RNA and protein expression of ACE and ACE2 in human diabetic nephropathy.	ACE2 ACE	7.69e-07	2	31	2	19077419
Pubmed	Angiotensin II regulates ACE and ACE2 in neurons through p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 signaling.	ACE2 ACE	7.69e-07	2	31	2	23535237
Pubmed	ACE/ACE2 balance might be instrumental to explain the certain comorbidities leading to severe COVID-19 cases.	ACE2 ACE	7.69e-07	2	31	2	33442728
Pubmed	Are angiotensin converting enzyme (ACE1/ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A single-center cohort study.	ACE2 ACE	7.69e-07	2	31	2	35190362
Pubmed	Association of ACE1 I/D rs1799752 and ACE2 rs2285666 polymorphisms with the infection and severity of COVID-19: A meta-analysis.	ACE2 ACE	7.69e-07	2	31	2	36148537
Pubmed	Combinatorial analysis of ACE and ACE2 polymorphisms reveals protection against COVID-19 worsening: A genetic association study in Brazilian patients.	ACE2 ACE	7.69e-07	2	31	2	38032879
Pubmed	Expression of ACE and ACE2 in patients with hypertensive nephrosclerosis.	ACE2 ACE	7.69e-07	2	31	2	21346373
Pubmed	Association of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene with type 2 diabetes in two ethnic groups of Jerba Island in Tunisia.	ACE2 ACE	7.69e-07	2	31	2	19286757
Pubmed	Polymorphisms of angiotensin-converting enzyme (ACE) and ACE2 are not associated with orthostatic blood pressure dysregulation in hypertensive patients.	ACE2 ACE	7.69e-07	2	31	2	19684612
Pubmed	Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population.	ACE2 ACE	7.69e-07	2	31	2	15937940
Pubmed	Role of angiotensin-converting enzyme (ACE and ACE2) imbalance on tourniquet-induced remote kidney injury in a mouse hindlimb ischemia-reperfusion model.	ACE2 ACE	7.69e-07	2	31	2	22580272
Pubmed	Assessment of ACE1 variants and ACE1/ACE2 expression in COVID-19 patients.	ACE2 ACE	7.69e-07	2	31	2	34774774
Pubmed	Angiotensin-converting enzymes (ACE and ACE2) are downregulated in renal tumors.	ACE2 ACE	7.69e-07	2	31	2	20692300
Pubmed	Effects of angiotensin-converting enzyme polymorphism on aortic elastic parameters in athletes.	ACE2 ACE	7.69e-07	2	31	2	16088128
Pubmed	Role and Interaction Between ACE1, ACE2 and Their Related Genes in Cardiovascular Disorders.	ACE2 ACE	7.69e-07	2	31	2	35245599
Pubmed	The impact of ACE2 polymorphisms (rs1978124, rs2285666, and rs2074192) and ACE1 rs1799752 in the mortality rate of COVID-19 in different SARS-CoV-2 variants.	ACE2 ACE	7.69e-07	2	31	2	37328914
Pubmed	Gene polymorphisms in angiotensin I converting enzyme (ACE I/D) and angiotensin II converting enzyme (ACE2 C-->T) protect against cerebral malaria in Indian adults.	ACE2 ACE	7.69e-07	2	31	2	20117248
Pubmed	Single Nucleotide Variants (SNVs) of Angiotensin-Converting Enzymes (ACE1 and ACE2): A Plausible Explanation for the Global Variation in COVID-19 Prevalence.	ACE2 ACE	7.69e-07	2	31	2	37051471
Pubmed	Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin-Converting Enzyme 2.	ACE2 ACE	7.69e-07	2	31	2	28935757
Pubmed	SNPs of ACE1 (rs4343) and ACE2 (rs2285666) genes are linked to SARS-CoV-2 infection but not with the severity of disease.	ACE2 ACE	7.69e-07	2	31	2	35305693
Pubmed	Novel findings: Expression of angiotensin-converting enzyme and angiotensin-converting enzyme 2 in thoracic aortic dissection and aneurysm.	ACE2 ACE	7.69e-07	2	31	2	25237166
Pubmed	Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.	CASP3 TNRC6C TNRC6A	9.76e-07	22	31	3	22187428
Pubmed	Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.	CASP3 TNRC6C TNRC6A	1.12e-06	23	31	3	28811219
Pubmed	Effect of ACE2 and angiotensin-(1-7) in a mouse model of early chronic kidney disease.	ACE2 ACE	2.31e-06	3	31	2	20357030
Pubmed	ACE and ACTN3 genotypes in older women: muscular phenotypes.	ACE2 ACE	2.31e-06	3	31	2	21072744
Pubmed	Higher ACE2 expression levels in epicardial cells than subcutaneous stromal cells from patients with cardiovascular disease: Diabetes and obesity as possible enhancer.	ACE2 ACE	2.31e-06	3	31	2	33251580
Pubmed	Gene polymorphisms and related risk factors in Mongolian hypertensive stroke patients.	ACE2 ACE	2.31e-06	3	31	2	20831027
Pubmed	The Role of ACE, ACE2, and AGTR2 Polymorphisms in COVID-19 Severity and the Presence of COVID-19-Related Retinopathy.	ACE2 ACE	2.31e-06	3	31	2	35885894
Pubmed	Gene polymorphisms predisposing to cardiac hypertrophy in patients with cardiac syndrome X.	ACE2 ACE	2.31e-06	3	31	2	19051693
Pubmed	Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies.	ACE2 IGHV4-39	2.31e-06	3	31	2	34534459
Pubmed	Host genetics and the profile of COVID-19 in indigenous people from the Brazilian Amazon: A pilot study with variants of the ACE1, ACE2 and TMPRSS2 genes.	ACE2 ACE	2.31e-06	3	31	2	38307396
Pubmed	Angiotensin converting enzyme (ACE) and ACE2 bind integrins and ACE2 regulates integrin signalling.	ACE2 ACE	2.31e-06	3	31	2	22523556
Pubmed	Association of angiotensin I converting enzyme, angiotensin II type 1 receptor and angiotensin I converting enzyme 2 gene polymorphisms with the dyslipidemia in type 2 diabetic patients of Chinese Han origin.	ACE2 ACE	2.31e-06	3	31	2	21670585
Pubmed	Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growth.	ACE LPL	2.31e-06	3	31	2	16416313
Pubmed	CSF angiotensin II and angiotensin-converting enzyme levels in anti-aquaporin-4 autoimmunity.	ACE2 ACE	2.31e-06	3	31	2	20541774
Pubmed	Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.	TNRC6C TNRC6A	2.31e-06	3	31	2	34108231
Pubmed	Gene variants rs5182, rs2074192, and rs4343 in the renin-angiotensin-aldosterone system are associated with symptom severity, higher odds of hospitalization, and death in COVID-19.	ACE2 ACE	2.31e-06	3	31	2	38697603
Pubmed	Renin-angiotensin system (RAS) enzymes and placental trophoblast syncytialisation.	ACE2 ACE	2.31e-06	3	31	2	35202745
Pubmed	Angiotensinogen and ACE gene polymorphisms and risk of atrial fibrillation in the general population.	ACE2 ACE	2.31e-06	3	31	2	18496132
Pubmed	Investigation of ACE, ACE2 and AGTR1 genes for association with nephropathy in Type 1 diabetes mellitus.	ACE2 ACE	2.31e-06	3	31	2	20854388
Pubmed	Downregulation of ACE, AGTR1, and ACE2 genes mediating SARS-CoV-2 pathogenesis by gut microbiota members and their postbiotics on Caco-2 cells.	ACE2 ACE	2.31e-06	3	31	2	36174833
Pubmed	Embarking Effect of ACE2-Angiotensin 1-7/Mas Receptor Axis in Benign Prostate Hyperplasia.	ACE2 ACE	2.31e-06	3	31	2	30055537
Pubmed	Nephropathy in type 1 diabetes: a manifestation of insulin resistance and multiple genetic susceptibilities? Further evidence from the Pittsburgh Epidemiology of Diabetes Complication Study.	ACE LPL	2.31e-06	3	31	2	12164879
Pubmed	Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.	TNRC6C TNRC6A	2.31e-06	3	31	2	16880270
Pubmed	Brain angiotensin-converting enzymes: role of angiotensin-converting enzyme 2 in processing angiotensin II in mice.	ACE2 ACE	2.31e-06	3	31	2	18263657
Pubmed	Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.	TNRC6C TNRC6A	2.31e-06	3	31	2	31670606
Pubmed	Association of ACE, ACE2 and UTS2 polymorphisms with essential hypertension in Han and Dongxiang populations from north-western China.	ACE2 ACE	2.31e-06	3	31	2	16866021
Pubmed	ACE/ACE2 ratio and MMP-9 activity as potential biomarkers in tuberculous pleural effusions.	ACE2 ACE	2.31e-06	3	31	2	23091417
Pubmed	Genetic polymorphisms of ACE1, ACE2, and TMPRSS2 associated with COVID-19 severity: A systematic review with meta-analysis.	ACE2 ACE	2.31e-06	3	31	2	34997794
Pubmed	ACE and ACE2 activity in diabetic mice.	ACE2 ACE	2.31e-06	3	31	2	16804085
Pubmed	Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism.	ACE2 ACE	4.61e-06	4	31	2	15283675
Pubmed	The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets.	TNRC6C TNRC6A	4.61e-06	4	31	2	23172285
Pubmed	Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1-FoxM1 complex.	ACE2 ACE	4.61e-06	4	31	2	27601681
Pubmed	Angiotensin-converting enzyme 2 protects from severe acute lung failure.	ACE2 ACE	4.61e-06	4	31	2	16001071
Pubmed	Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.	TNRC6C TNRC6A	4.61e-06	4	31	2	21063388
Pubmed	Low renin-angiotensin system activity gene polymorphism and dysplasia associated with posterior urethral valves.	ACE2 ACE	4.61e-06	4	31	2	16006956
Pubmed	Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein.	TNRC6C TNRC6A	4.61e-06	4	31	2	20181956
Pubmed	Confirmation that the renin gene distal enhancer polymorphism REN-5312C/T is associated with increased blood pressure.	ACE2 ACE	4.61e-06	4	31	2	20160196
Pubmed	Vascular wall ACE is not required for atherogenesis in ApoE(-/-) mice.	ACE2 ACE	4.61e-06	4	31	2	19880118
Pubmed	SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors.	MRC1 ACE2	7.68e-06	5	31	2	32766577
Pubmed	A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.	ACE2 ACE	7.68e-06	5	31	2	10969042
Pubmed	Molecular characterization of mouse and rat CPP32 beta gene encoding a cysteine protease resembling interleukin-1 beta converting enzyme and CED-3.	CASP3 LPL	7.68e-06	5	31	2	8761296
Pubmed	[Complex analysis of genetic predisposition to ischemic stroke in Russians].	ACE LPL	1.15e-05	6	31	2	19899640
Pubmed	Effect of six candidate genes on early aging in a French population.	ACE LPL	1.15e-05	6	31	2	12889841
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC6C TNRC6A	3.79e-04	25	21	2	775
ToppCell	facs-Brain_Myeloid-Cerebellum\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF704 MRC1 EMB LPL	4.07e-06	156	31	4	28c4fb4d2c6c47696c3a6722998f9da5a8923323
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 PLD3 SLC39A11 LPL	5.46e-06	168	31	4	a1755afa2cc50960ba60e07d84d61be429cdea72
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 RAPGEF2 EMB LPL	6.13e-06	173	31	4	20f7dfe7d92a3dbec9da9a1f3185aa10cb8f0a3c
ToppCell	MS\|World / Condition, Cell_class and T cell subcluster	MRC1 PKHD1L1 IGHV4-39 LPL	7.32e-06	181	31	4	99f054a586a95947528dc3fd8043c1bda5e74cc4
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 ATP6V0A1 PLD3 LPL	7.81e-06	184	31	4	fe9ea4d0e0be820e95eaf9bb42a5560d0e177574
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	MRC1 PLD3 SLC39A11 LPL	7.98e-06	185	31	4	0e8064bb317f26959d3c59b4f73d0c455161ccd7
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 ATP6V0A1 PLD3 LPL	8.15e-06	186	31	4	7950e03ea080238c168b9d807e217f459acdfb28
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACE2 PLD3 EMB LPL	8.51e-06	188	31	4	e99e3765b48392c987cf0c5ccbded0655637d7b7
ToppCell	facs-Pancreas-Endocrine-3m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACE2 PLD3 EMB LPL	9.05e-06	191	31	4	b3de0393d6510543533cd851e47a0f95739a0e4e
ToppCell	Myeloid-Myeloid-B_(Activated_Macrophage)\|Myeloid / shred on cell class and cell subclass (v4)	MRC1 ATP6V0A1 PLD3 LPL	9.05e-06	191	31	4	7bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACE2 PLD3 EMB LPL	9.05e-06	191	31	4	657297cd19d05a7e7bb74fc3a086fbd95f47aae4
ToppCell	368C-Myeloid-Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MRC1 PLD3 ACE LPL	9.43e-06	193	31	4	c8883731567d0def96e4105dc34b995d1275ddf4
ToppCell	Bronchial_Biopsy-Immune-Luminal_Macrophages\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	MRC1 PLD3 ACE LPL	9.82e-06	195	31	4	6800c17026ec6c56132bf4664b8fcd74d7836579
ToppCell	343B-Myeloid-Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MRC1 PLD3 ACE LPL	1.02e-05	197	31	4	1b6f7a62b7fcfd55c25c5840353eed7183050860
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	MRC1 PLD3 SLC39A11 LPL	1.02e-05	197	31	4	1ded28732ea5d1f9ebca0b136575103540600ff1
ToppCell	367C-Myeloid-Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MRC1 PLD3 ACE LPL	1.02e-05	197	31	4	f5c21f0d363b5c298a2b82f6dff4f369397b5f25
ToppCell	356C-Myeloid-Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MRC1 PLD3 ACE LPL	1.02e-05	197	31	4	896242e1651435bbc5b6521417e1aca36c215acd
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MRC1 PLD3 ACE LPL	1.04e-05	198	31	4	d18270f45f170a8da6105f1c212cada6aab75412
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MRC1 PLD3 ACE LPL	1.04e-05	198	31	4	3b4611c9ee4d42e042a29ddb4580a95938d87d65
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MRC1 PLD3 SLC39A11 LPL	1.06e-05	199	31	4	54a54ad983503ed515d476882d86b17d97892037
ToppCell	BAL-Control-cDC_0\|Control / Compartment, Disease Groups and Clusters	MRC1 PLD3 ACE LPL	1.06e-05	199	31	4	4518ffa51ead9da1ddf07bf048b18602e50f0f84
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MRC1 PLD3 ACE LPL	1.09e-05	200	31	4	ea039de8bd8b325845ce361f84e600c6dad922ed
ToppCell	10x5'-Lung-Myeloid_Mac-Alveolar_macrophages\|Lung / Manually curated celltypes from each tissue	MRC1 PLD3 ACE LPL	1.09e-05	200	31	4	3b236900df407bf5a8c44e76d003a7a37d251db6
ToppCell	COVID-19-Myeloid-MoAM2,_CCL18\|Myeloid / Condition, Lineage and Cell class	MRC1 ATP6V0A1 PLD3 ACE	1.09e-05	200	31	4	a60346c5ea7a3dae1ad3c5dc6c6eca65b64c6888
ToppCell	COVID-19-Myeloid-MoAM2,_CCL18\|COVID-19 / Condition, Lineage and Cell class	MRC1 ATP6V0A1 PLD3 ACE	1.09e-05	200	31	4	b0a50622d00335843efad86bc56a1e910019984b
ToppCell	Globus_pallidus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Lmcd1_(Mural.Rgs5Acta2.Lmcd1)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ZNF704 ACE2 POU2F3	5.60e-05	107	31	3	0b45241cc52d10225966b49941efb66997184158
ToppCell	Globus_pallidus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Lmcd1_(Mural.Rgs5Acta2.Lmcd1)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ZNF704 ACE2 POU2F3	5.60e-05	107	31	3	2f84089acc794b43ee59452dc8f90ca7261ebd41
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_3\|390C / Donor, Lineage, Cell class and subclass (all cells)	MRC1 ACE LPL	1.59e-04	152	31	3	f717aae4882e9b67e5e40f4ef5b0d35f74a89165
ToppCell	facs-Brain_Myeloid-Cortex-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 EMB TIAM2	1.62e-04	153	31	3	0ef7c45cdd854c79e527006034029767f8e108b2
ToppCell	facs-Brain_Myeloid-Cortex-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DISP3 ACE EMB	1.65e-04	154	31	3	1e088b0d4a44267f46a9b643f46a1aba784686b1
ToppCell	facs-Brain_Myeloid-Cortex_-18m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ACE EMB	1.71e-04	156	31	3	2ba838bc864c2c1767bcab7bb4d790af96b91387
ToppCell	367C-Myeloid-Macrophage-SPP1+_Macrophage_3\|367C / Donor, Lineage, Cell class and subclass (all cells)	MRC1 SLC39A11 LPL	1.78e-04	158	31	3	0559cc032d0b518bb9e55aa3495f5573bd8e87dd
ToppCell	tumor_Lymph_Node_/_Brain-B_lymphocytes-MALT_B_cells\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	PKHD1L1 IGHV4-39 CCDC144A	1.81e-04	159	31	3	204e5a675f4684c9570c24c8d34bbf632fd8164a
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 EMB LPL	1.81e-04	159	31	3	0c2437da5443fc3aff66f8ef311f02aa434a1fb0
ToppCell	PND07-28-samps-Myeloid-Macrophage-macrophage-B\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	MRC1 PLD3 LPL	1.84e-04	160	31	3	694bf1f1952bd8ab444819f533da24fa2b73f701
ToppCell	facs-Brain_Myeloid-Cerebellum-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ACE EMB	1.84e-04	160	31	3	1f7acdc8b08152d5817fc53bbf47b4a22d9c91b5
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PLD3 LPL	1.84e-04	160	31	3	0544bc465af208da448858d6e174ff56f2e08a46
ToppCell	PND07-28-samps-Myeloid-Macrophage\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	MRC1 PLD3 LPL	1.91e-04	162	31	3	7c73fe8388af370461e04097cf145cbc9847285b
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 PLD3 LPL	1.91e-04	162	31	3	d712bc31840ad1523e3dbf884acbb428a8995001
ToppCell	368C-Lymphocytic-Plasma_cell\|368C / Donor, Lineage, Cell class and subclass (all cells)	IGHV4-61 PKHD1L1 IGHV4-39	1.91e-04	162	31	3	f945688815229c8386cbcbf46deee7df316fa8d3
ToppCell	368C-Lymphocytic-Plasma_cell-\|368C / Donor, Lineage, Cell class and subclass (all cells)	IGHV4-61 PKHD1L1 IGHV4-39	1.91e-04	162	31	3	c21a54310b239d999bbc9d8fb5e8fda16e0bc336
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MRC1 PLD3 EMB	1.95e-04	163	31	3	4b8abbad4df040c895e3afb240759ebbc66b4d0e
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PLD3 LPL	2.05e-04	166	31	3	91eeb48680dd07ae4115afacdc0a8f6fa18885e5
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MRC1 ACE LPL	2.09e-04	167	31	3	a48349f189f6a8d563744b0a294c3974f3a18f50
ToppCell	facs-Skin-Anagen-24m-Epithelial-epidermal_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACE2 ATP6V0A1 POU2F3	2.09e-04	167	31	3	02c89069dcd0e87f7502e32b14e7cbd3cab81a09
ToppCell	BAL-Mild-Lymphocyte-B\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGHV4-61 PKHD1L1 IGHV4-39	2.17e-04	169	31	3	307571e57c3bfdf15f0fe1a8b36585e8e4f8a207
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 EMB LPL	2.17e-04	169	31	3	305cedbd97059029d7d2a248a8a4b6cfe281aa54
ToppCell	BAL-Mild-Lymphocyte-B-B_cell-B_cell-B_activate-7\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGHV4-61 PKHD1L1 IGHV4-39	2.20e-04	170	31	3	ee2ee67d90ae4596de8ccd620e37c82cf51651d4
ToppCell	BAL-Mild-Lymphocyte-B-B_cell-B_cell\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGHV4-61 PKHD1L1 IGHV4-39	2.20e-04	170	31	3	d7ca0c6ce5d2b7de99346f87e07aa7fe728fa08a
ToppCell	BAL-Mild-Lymphocyte-B-B_cell\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGHV4-61 PKHD1L1 IGHV4-39	2.20e-04	170	31	3	52787f6d529c285d9f0c04cc022710ead5b89b3f
ToppCell	metastatic_Brain-B_lymphocytes-Plasma_cells\|metastatic_Brain / Location, Cell class and cell subclass	IGHV4-61 PKHD1L1 IGHV4-39	2.20e-04	170	31	3	53634da9e9c72f6400639954c286c6e38ea5a188
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PLD3 LPL	2.20e-04	170	31	3	067657ca7fcf5a0ffbd168b5c4609a30ca508f22
ToppCell	facs-Trachea-18m-Hematologic-myeloid-granulocyte-granulocyte_l26\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CASP3 TIAM2 GP1BA	2.20e-04	170	31	3	4b1c84b35b7242a297ffdb9c23a6d982acf1bed5
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 PLD3 LPL	2.28e-04	172	31	3	584af6537685cb459bf0fc298e6f46872016c116
ToppCell	3'_v3-GI_small-bowel-Mast-Mast_cell_granulo-myelo\|GI_small-bowel / Manually curated celltypes from each tissue	ZNF704 IGHV4-39 TIAM2	2.28e-04	172	31	3	3df11aefc09762fd1f94441324551178e030b249
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF704 MRC1 LPL	2.32e-04	173	31	3	869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCell	Globus_pallidus-Endothelial-MURAL-M1(Rgs5Acta2)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ZNF704 ACE2 POU2F3	2.32e-04	173	31	3	51328a60ffaf34fa0f7df6084d348b5efc9917f5
ToppCell	Globus_pallidus-Endothelial-MURAL\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ZNF704 ACE2 POU2F3	2.32e-04	173	31	3	b77cd5dbda3a206922f20224f4e10a3bf712f7db
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF704 MRC1 LPL	2.32e-04	173	31	3	0672bd8a4a9d18af343d01f09253fb3388896c10
ToppCell	facs-Brain_Myeloid-Cerebellum-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF704 MRC1 LPL	2.32e-04	173	31	3	870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Plasma_cells-IgM_plasma_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DISP3 PKHD1L1 CCDC144A	2.32e-04	173	31	3	77e2b2e66c89984769f2800bdeeab42f9cf9fc46
ToppCell	metastatic_Brain-B_lymphocytes-MALT_B_cells\|metastatic_Brain / Location, Cell class and cell subclass	IGHV4-61 PKHD1L1 IGHV4-39	2.44e-04	176	31	3	50e207403d48ce1b55a78897adb5519a2430a626
ToppCell	Control-Lymphoid_P\|Control / Disease group, lineage and cell class	IGHV4-61 PKHD1L1 IGHV4-39	2.44e-04	176	31	3	d895a6b295cd649273ff80ad7785a3e0ae4c728a
ToppCell	droplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 PLD3 LPL	2.44e-04	176	31	3	e74ad0db3b05897edcfabeb11008ede2b9eeb638
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 PLD3 LPL	2.44e-04	176	31	3	270d7908dbd84028958d257f94941dc685e20255
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 PLD3 LPL	2.44e-04	176	31	3	b0b87eebcf5c994386b39ca607e17f10e9d9de74
ToppCell	Control-Lymphoid_P-Plasmablast\|Control / Disease group, lineage and cell class	IGHV4-61 PKHD1L1 IGHV4-39	2.44e-04	176	31	3	4b4416f342b732d2cc60133838728880326257d8
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	ZNF704 ADAMTS5 PLEKHF1	2.44e-04	176	31	3	bfa1633e1b7a8a2f04d37fa07284fe9bc0199f46
ToppCell	10x5'v1-week_14-16-Myeloid_macrophage-stroma-monocytoid_macrophage\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	MRC1 PLD3 POU2F3	2.48e-04	177	31	3	945b2d0723a0a35c767604ae607d2c2d53bf0c82
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 PLD3 LPL	2.48e-04	177	31	3	67cc3a6461db5e0678f96b18224aeb83ad34b0f4
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS5 ALPK1 GP1BA	2.48e-04	177	31	3	e8bb4f8ecd5e283efec966b9fc2040a6152d5551
ToppCell	droplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 PLD3 LPL	2.48e-04	177	31	3	71919b5c9bfa87fdd2cd44dfa057b66ea081be5d
ToppCell	(2)_Plasma_cells\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	IGHV4-61 PKHD1L1 IGHV4-39	2.48e-04	177	31	3	ed3c936bb69f9bc7291b4f6cde1d204078117c48
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.6.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MRC1 ACE LPL	2.48e-04	177	31	3	929cd8f530ce001623735da53b7278d02522e2b5
ToppCell	VE-plasma\|VE / Condition, Cell_class and T cell subcluster	IGHV4-61 PKHD1L1 IGHV4-39	2.48e-04	177	31	3	0c1cc0834de55717cb4f69d020339060ce2c9a03
ToppCell	VE-plasma-\|VE / Condition, Cell_class and T cell subcluster	IGHV4-61 PKHD1L1 IGHV4-39	2.48e-04	177	31	3	3a3c94cf30012e2aa266bc4d7fe772e45fa90f6d
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PLD3 LPL	2.48e-04	177	31	3	26bad614560609d318bfc9c235a698bca4e1c22c
ToppCell	droplet-Marrow-nan-21m-Myeloid-monocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACE EMB LPL	2.48e-04	177	31	3	b860013f1fd397400a62d66ab521cfc81349ffe2
ToppCell	PND14-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CASP3 SLC39A11 GP1BA	2.52e-04	178	31	3	63f5880a5b514e20ef2c07a6a9cb8df34e6cede5
ToppCell	PND14-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CASP3 SLC39A11 GP1BA	2.52e-04	178	31	3	82c84f8b8a7e6a3d3be3351b348a37143279c100
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MRC1 PLD3 LPL	2.52e-04	178	31	3	0b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell	3'_v3-bone_marrow-Myeloid_Mac-Macrophage\|bone_marrow / Manually curated celltypes from each tissue	ZNF704 MRC1 LPL	2.52e-04	178	31	3	11a338032b59b936c5e65517c4160f7dd47a2cda
ToppCell	PND14-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CASP3 SLC39A11 GP1BA	2.52e-04	178	31	3	cb91558469ae0748106fb0b6d702edb0ff21a884
ToppCell	droplet-Lung-30m-Hematologic-myeloid-interstitial_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 PLD3 LPL	2.52e-04	178	31	3	c85de851b39cb8ef7ea1866ab64c6a387788273a
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MRC1 ZP2 PKHD1L1	2.56e-04	179	31	3	35fe9961e228ce255e3317fc244efa35b5adbf8b
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZP2 PKHD1L1 GP1BA	2.56e-04	179	31	3	1c0c0647a111f691dae55f4ed8c51006059ce020
ToppCell	droplet-Lung-30m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_33\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 PLD3 LPL	2.56e-04	179	31	3	13d80ae2e43a5daad0aeb5f47338efca2c58800a
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Macrophage\|lymph-node_spleen / Manually curated celltypes from each tissue	MRC1 ACE LPL	2.56e-04	179	31	3	b4430f633711cecf793e8e76e766a66ff1eff473
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MRC1 ZP2 PKHD1L1	2.56e-04	179	31	3	ab3d08b51cd7a37582305615ee221c7a2af83b40
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Plasma_cells-IgG_plasma_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGHV4-61 PKHD1L1 CCDC144A	2.61e-04	180	31	3	588461d603dafa74e274a1dea021fd568e7f7875
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 PLD3 EMB	2.61e-04	180	31	3	cc31d2cd06161300b91b17a67bb432b75f0d719b
ToppCell	droplet-Lung-LUNG-30m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PLD3 LPL	2.65e-04	181	31	3	8fcdab61fad2efd324d2b27c58f5a594f1dc15de
ToppCell	BAL-Mild-Lymphocyte-B\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGHV4-61 PKHD1L1 IGHV4-39	2.65e-04	181	31	3	700adfb41e4e377530f0dd31be89e12f109f3469
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IGHV4-61 PKHD1L1 IGHV4-39	2.65e-04	181	31	3	f7b08f662eb77ee7a777c6525ddc3195046aaf65
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 PLD3 LPL	2.69e-04	182	31	3	21dcab170ffeef89faa9fee5008568cb6e15c694
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 PLD3 EMB	2.69e-04	182	31	3	94d061b7b5ebbfc564c644bc8b2d52341927145d
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Mac-Cycling_Myeloid-Mac\|lymph-node_spleen / Manually curated celltypes from each tissue	MRC1 TIAM2 LPL	2.69e-04	182	31	3	84018a84e1aa52fa52ccfc26db9cd1fb6d535b31
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PLD3 LPL	2.69e-04	182	31	3	3dec003bad0f3716cf8163861a9d4302a7d6df8c
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PLD3 LPL	2.69e-04	182	31	3	be48ce85991bceeff938ba080e6bf9cc62176b05
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS5 ACE LPL	2.74e-04	183	31	3	5cfcd589a480e67654d3d94e71916f122150db10
Drug	doxazosin	CASP3 ACE2 ATP6V0A1 ACE LPL	6.32e-08	83	29	5	CID000003157
Drug	Valsartan	CASP3 MRC1 ACE2 ACE LPL	3.85e-07	119	29	5	ctd:D000068756
Drug	AC1MVZ0B	CASP3 ACE2 ACE EMB	3.97e-07	48	29	4	CID003691183
Drug	Scrip	ACE2 ACE EMB	8.37e-07	15	29	3	CID000146807
Drug	Ahtp-BK	ACE2 ACE	1.57e-06	2	29	2	CID000128372
Drug	bradykinin potentiator c	ACE2 ACE	1.57e-06	2	29	2	CID004597608
Drug	tebanyl	ACE2 ACE	1.57e-06	2	29	2	CID000008609
Drug	isomartynoside	ACE2 ACE	1.57e-06	2	29	2	CID006476337
Drug	2-nitrophenyl diethyl phosphate	ACE2 ACE	1.57e-06	2	29	2	CID003014292
Drug	dansyltriglycine	ACE2 ACE	1.57e-06	2	29	2	CID000194208
Drug	CV-5975	ACE2 ACE	1.57e-06	2	29	2	CID003035825
Drug	EU-4881	ACE2 ACE	1.57e-06	2	29	2	CID000146389
Drug	EU-4865	ACE2 ACE	1.57e-06	2	29	2	CID000132472
Drug	A58365B	ACE2 ACE	1.57e-06	2	29	2	CID000137366
Drug	A58365A	ACE2 ACE	1.57e-06	2	29	2	CID000137365
Drug	MDL 27,788	ACE2 ACE	1.57e-06	2	29	2	CID005748412
Drug	EU-5031	ACE2 ACE	1.57e-06	2	29	2	CID000194686
Drug	BRL 36378	ACE2 ACE	1.57e-06	2	29	2	CID000134835
Drug	chlorambucyl-proline	ACE2 ACE	1.57e-06	2	29	2	CID000133596
Drug	AC1NNL9J	ACE2 ACE	1.57e-06	2	29	2	CID005046512
Drug	DU-1227	ACE2 ACE	1.57e-06	2	29	2	CID000156284
Drug	Ketoace	ACE2 ACE	1.57e-06	2	29	2	CID000156271
Drug	I5b2	ACE2 ACE	1.57e-06	2	29	2	CID000125070
Drug	MDL27,467A	ACE2 ACE	1.57e-06	2	29	2	CID000194915
Drug	Lisinopril	ACE2 ACE	1.57e-06	2	29	2	DB00722
Drug	Moexipril	ACE2 ACE	1.57e-06	2	29	2	DB00691
Drug	AC1L9JWW	ACE2 ACE EMB	2.43e-06	21	29	3	CID000446637
Drug	5f-1	ACE2 ACE GP1BA	2.81e-06	22	29	3	CID015991535
Drug	AC1MJ2VJ	ACE2 ACE	4.70e-06	3	29	2	CID003084602
Drug	WY-45,368	ACE2 ACE	4.70e-06	3	29	2	CID000127103
Drug	CGS 13934	ACE2 ACE	4.70e-06	3	29	2	CID000134126
Drug	BP1.137	ACE2 ACE	4.70e-06	3	29	2	CID005311337
Drug	MC-838	ACE2 ACE	4.70e-06	3	29	2	CID005488868
Drug	L-681,176	ACE2 ACE	4.70e-06	3	29	2	CID000124628
Drug	ethyl glyoxalate	ACE2 ACE	4.70e-06	3	29	2	CID000070211
Drug	Wf 10129	ACE2 ACE	4.70e-06	3	29	2	CID003080984
Drug	MDL 27,088	ACE2 ACE	4.70e-06	3	29	2	CID005489408
Drug	C112 Peptide	ACE2 ACE	4.70e-06	3	29	2	CID000181457
Drug	C111 Peptide	ACE2 ACE	4.70e-06	3	29	2	CID000181456
Drug	aladotril	ACE2 ACE	4.70e-06	3	29	2	CID006450804
Drug	aladotrilat	ACE2 ACE	4.70e-06	3	29	2	CID006450805
Drug	Rev 5975	ACE2 ACE	4.70e-06	3	29	2	CID000127983
Drug	tert-butyl L-alaninate	ACE2 ACE	4.70e-06	3	29	2	CID000089016
Drug	poly(vinylidene fluoride	ACE2 PLD3 ACE LPL	4.81e-06	89	29	4	CID000006369
Drug	Utibaprilo	ACE2 ACE	9.38e-06	4	29	2	CID000060359
Drug	Rac X 65	ACE2 ACE	9.38e-06	4	29	2	CID005748390
Drug	AC1L9QEO	ACE2 ACE	9.38e-06	4	29	2	CID000452589
Drug	BW-175	ACE2 ACE	9.38e-06	4	29	2	CID000129247
Drug	Hoe 288	ACE2 ACE	9.38e-06	4	29	2	CID000130318
Drug	Hoe 065	ACE2 ACE	9.38e-06	4	29	2	CID000197279
Drug	Moveltipril [INN]	ACE2 ACE	9.38e-06	4	29	2	CID005745793
Drug	Endocrine Disruptors	CASP3 MRC1 ACE2 ZP2	1.12e-05	110	29	4	ctd:D052244
Drug	sodium; lithium	ACE2 ACE LPL	1.29e-05	36	29	3	CID012725854
Drug	C12063	CASP3 PLD3 ACE ZP2 EMB LPL	1.42e-05	429	29	6	CID005282055
Drug	gnoscopine	CASP3 ACE2 ACE	1.52e-05	38	29	3	CID000004544
Drug	Spiraprilate	ACE2 ACE	1.56e-05	5	29	2	CID000134290
Drug	BW A575C	ACE2 ACE	1.56e-05	5	29	2	CID000128240
Drug	dansylglycine	ACE2 ACE	1.56e-05	5	29	2	CID000070666
Drug	AC1L1DX8	ACE2 ACE	1.56e-05	5	29	2	CID000002546
Drug	Ace inhibitor BG-2	ACE2 ACE	1.56e-05	5	29	2	CID000115370
Drug	2-oxo-4-phenylbutyric acid	ACE2 ACE	1.56e-05	5	29	2	CID000069732
Drug	EXP132	ACE2 ACE	1.56e-05	5	29	2	CID000132313
Drug	Locustamyotropin	ACE2 ACE	1.56e-05	5	29	2	CID005748449
Drug	AC1L1SQ2	ACE2 ACE	1.56e-05	5	29	2	CID000060183
Drug	FQp	ACE2 ACE	1.56e-05	5	29	2	CID000001722
Drug	CGS 22989	ACE2 ACE	1.56e-05	5	29	2	CID000130198
Drug	Enalkiren	ACE2 ACE	1.56e-05	5	29	2	CID000060594
Drug	B 4146	ACE2 ACE	2.34e-05	6	29	2	CID000128385
Drug	E 4177	ACE2 ACE	2.34e-05	6	29	2	CID000131857
Drug	Du 1777	ACE2 ACE	2.34e-05	6	29	2	CID003081108
Drug	Ab 47	ACE2 ACE	2.34e-05	6	29	2	CID005487171
Drug	EXP3312	ACE2 ACE	2.34e-05	6	29	2	CID000196704
Drug	AC1Q5KBJ	ACE2 ACE	2.34e-05	6	29	2	CID000064925
Drug	Acrip	ACE2 ACE	2.34e-05	6	29	2	CID000163664
Drug	Ala-Trp	ACE2 ACE	2.34e-05	6	29	2	CID000085362
Drug	Leu-Gly-Pro	ACE2 ACE	2.34e-05	6	29	2	CID000439585
Drug	AC1Q5R6K	ACE2 ACE	2.34e-05	6	29	2	CID000114973
Drug	UP 269-6	ACE2 ACE	2.34e-05	6	29	2	CID000132840
Drug	Ro 31-8472	ACE2 ACE	2.34e-05	6	29	2	CID000132616
Drug	tasosartan	ACE2 ACE	3.28e-05	7	29	2	CID000060919
Drug	octahydroindole-2-carboxylic acid	ACE2 ACE	3.28e-05	7	29	2	CID003274680
Drug	VAL-TRP	ACE2 ACE	3.28e-05	7	29	2	CID000168182
Drug	Pentoprilum	ACE2 ACE	3.28e-05	7	29	2	CID000054938
Drug	zabicipril	ACE2 ACE	3.28e-05	7	29	2	CID000071262
Drug	AC1Q5THZ	CASP3 PLD3 ACE ZP2 LPL GP1BA	3.44e-05	502	29	6	CID000001959
Drug	L-Leu-L-Pro	ACE2 ACE POU2F3	3.50e-05	50	29	3	CID000080817
Drug	sodium chlorate	MRC1 LPL GP1BA	3.71e-05	51	29	3	CID000516902
Drug	diethylenetriaminepentaacetic acid	CASP3 ACE2 ACE	3.94e-05	52	29	3	CID000003053
Drug	amyl nitrite	ACE2 ACE LPL	4.17e-05	53	29	3	CID000008053
Drug	idrapril	ACE2 ACE	4.37e-05	8	29	2	CID000065960
Drug	X x 5	ACE2 ACE	4.37e-05	8	29	2	CID000448281
Drug	Boc-ca-phe	ACE2 ACE	4.37e-05	8	29	2	CID005487215
Drug	Z-ca-gly-phe	ACE2 ACE	4.37e-05	8	29	2	CID000195338
Drug	Abbott-81988	ACE2 ACE	4.37e-05	8	29	2	CID000132387
Drug	EXP3880	ACE2 ACE	4.37e-05	8	29	2	CID000132149
Drug	nolomirole	ACE2 ACE	4.37e-05	8	29	2	CID000216238
Drug	zabiciprilat	ACE2 ACE	4.37e-05	8	29	2	CID000065680
Drug	Neurotensin (1-10)	ACE2 ACE	4.37e-05	8	29	2	CID003085266
Drug	CHEMBL1783187	ACE2 ACE	5.61e-05	9	29	2	CID005230731
Drug	angiotensin I	ACE2 ACE	5.61e-05	9	29	2	CID000447320
Disease	non-arteritic anterior ischemic optic neuropathy (is_implicated_in)	ACE GP1BA	1.07e-05	5	31	2	DOID:0050864 (is_implicated_in)
Disease	Nodular glomerulosclerosis	ACE2 ALPK1 ACE	1.09e-05	41	31	3	C0017667
Disease	Diabetic Nephropathy	ACE2 ALPK1 ACE	1.35e-05	44	31	3	C0011881
Disease	Early Childhood Epilepsy, Myoclonic	RAPGEF2 TNRC6A	2.98e-05	8	31	2	C0393695
Disease	Idiopathic Myoclonic Epilepsy	RAPGEF2 TNRC6A	2.98e-05	8	31	2	C0338478
Disease	Symptomatic Myoclonic Epilepsy	RAPGEF2 TNRC6A	2.98e-05	8	31	2	C0338479
Disease	Myoclonic Encephalopathy	RAPGEF2 TNRC6A	2.98e-05	8	31	2	C0438414
Disease	Benign Infantile Myoclonic Epilepsy	RAPGEF2 TNRC6A	2.98e-05	8	31	2	C0751120
Disease	Myoclonic Absence Epilepsy	RAPGEF2 TNRC6A	2.98e-05	8	31	2	C0393703
Disease	pre-malignant neoplasm (implicated_via_orthology)	CASP3 ACE	3.83e-05	9	31	2	DOID:0060071 (implicated_via_orthology)
Disease	Myoclonic Epilepsy	RAPGEF2 TNRC6A	3.83e-05	9	31	2	C0014550
Disease	Hypertensive disease	ACE2 ACE LPL GP1BA	4.57e-05	190	31	4	C0020538
Disease	Epilepsy, Myoclonic, Infantile	RAPGEF2 TNRC6A	4.78e-05	10	31	2	C0917800
Disease	Myoclonic Astatic Epilepsy	RAPGEF2 TNRC6A	5.84e-05	11	31	2	C0393702
Disease	Infantile Severe Myoclonic Epilepsy	RAPGEF2 TNRC6A	8.27e-05	13	31	2	C0751122
Disease	myocardial infarction (is_implicated_in)	ACE LPL GP1BA	1.54e-04	99	31	3	DOID:5844 (is_implicated_in)
Disease	COVID-19 (is_implicated_in)	ACE2 ACE	2.22e-04	21	31	2	DOID:0080600 (is_implicated_in)
Disease	osteoarthritis (biomarker_via_orthology)	CASP3 ADAMTS5	2.22e-04	21	31	2	DOID:8398 (biomarker_via_orthology)
Disease	hypertension (is_implicated_in)	ACE2 ACE LPL	2.78e-04	121	31	3	DOID:10763 (is_implicated_in)
Disease	Cerebral Hemorrhage	CASP3 ACE	3.97e-04	28	31	2	C2937358
Disease	primary biliary cholangitis (biomarker_via_orthology)	ACE2 ACE	3.97e-04	28	31	2	DOID:12236 (biomarker_via_orthology)
Disease	lung disease (biomarker_via_orthology)	ACE2 ACE	6.22e-04	35	31	2	DOID:850 (biomarker_via_orthology)
Disease	myocardial infarction (biomarker_via_orthology)	CASP3 ACE2 ACE	6.29e-04	160	31	3	DOID:5844 (biomarker_via_orthology)
Disease	Cardiovascular Diseases	ACE LPL	6.58e-04	36	31	2	C0007222
Disease	congestive heart failure (implicated_via_orthology)	ACE2 ACE	8.54e-04	41	31	2	DOID:6000 (implicated_via_orthology)
Disease	middle cerebral artery infarction (implicated_via_orthology)	CASP3 ACE	1.03e-03	45	31	2	DOID:3525 (implicated_via_orthology)
Disease	Celiac Disease	ACE LPL	1.12e-03	47	31	2	C0007570
Disease	diabetic retinopathy (is_implicated_in)	ACE2 ACE	1.27e-03	50	31	2	DOID:8947 (is_implicated_in)
Disease	hypertension (biomarker_via_orthology)	CASP3 ACE2 ACE	1.72e-03	227	31	3	DOID:10763 (biomarker_via_orthology)
Disease	Brain Ischemia	CASP3 ACE	1.82e-03	60	31	2	C0007786
Disease	Cerebral Ischemia	CASP3 ACE	1.82e-03	60	31	2	C0917798
Disease	pancreatic ductal carcinoma (is_marker_for)	ACE2 ACE	1.88e-03	61	31	2	DOID:3587 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PASGFWSTLGWAFTN	DISP3	56	Q9P2K9
TDTGAYWRSWYNSPT	ACE	221	P12821
YYSTSSHGNWGSWGS	ADAMTS5	561	Q9UNA0
ESPGCFWNSLGWSFS	LINC00528	126	Q8N1L1
WYLGYPGDQWSSGFS	CCDC144CP	36	Q8IYA2
SSGFSYSWWKNSVGS	CCDC144CP	46	Q8IYA2
PGYYSWRNSKDGSWF	CASP3	201	P42574
SPWSYLNSSGSSWVS	ALPK1	946	Q96QP1
YWFLGQAGSSIPSTW	PLD3	251	Q8IV08
GSVSSGSYYWSWIRQ	IGHV4-61	46	A0A0C4DH41
SDSYFSWSDWWSSPG	LPL	411	P06858
SGGSISSSSYYWGWI	IGHV4-39	51	P01824
SASSFNSSGSWYRWN	POU2F3	416	Q9UKI9
WYLGYPGDQWSSGFS	CCDC144B	36	Q3MJ40
SSGFSYSWWKNSVGS	CCDC144B	46	Q3MJ40
NSFVGWSTDWSPYAD	ACE2	601	Q9BYF1
TPWGLFYSWSTASLD	GP1BA	321	P07359
FPLNWTWYSSNGSVK	EMB	186	Q6PCB8
SSGFPYSWWKNSVGS	CCDC144A	46	A2RUR9
GFSTWRAFWYGQLSG	SLC39A11	256	Q8N1S5
WGFKTYRTSSLWNSS	MTERF3	56	Q96E29
FTWSDGSPVSYENWA	MRC1	726	P22897
WPSSVEFYASGVAWS	PLEKHF1	261	Q96S99
TWGASPLGWTSSYSS	TNRC6C	1486	Q9HCJ0
PLGWTSSYSSGSAWS	TNRC6C	1491	Q9HCJ0
QSRASWASSTGYWGE	RAPGEF2	1321	Q9Y4G8
SSLSSESSWYDSPWG	TIAM2	241	Q8IVF5
GSYSSSSNSGDWGWD	SLC2A4RG	146	Q9NR83
YVDAWSSNFSWGGKS	PKHD1L1	2176	Q86WI1
VPSSTSSSGYWSWSA	ZNF704	121	Q6ZNC4
SSSGYWSWSAPSDQS	ZNF704	126	Q6ZNC4
GSSWSVRPMFTYNWT	ATP6V0A1	476	Q93050
SVAFSPDGSWFAWSQ	WSB2	31	Q9NYS7
SSWPVFSSAWNYFAG	TRIM4	336	Q9C037
SPSGWFNAGWSTYRS	ZP2	11	Q05996
TSLWGTPHYSTSLWG	TNRC6A	1916	Q8NDV7