Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transcription factor binding	NOLC1 TBX3 NOP58 NKX2-2 TAF13 TRIP4 TFDP2 DDX54	1.25e-04	753	41	8	GO:0008134
GeneOntologyMolecularFunction	general transcription initiation factor binding	NOLC1 NOP58 TAF13	3.07e-04	64	41	3	GO:0140296
GeneOntologyMolecularFunction	basal RNA polymerase II transcription machinery binding	NOLC1 NOP58 BRD4	3.36e-04	66	41	3	GO:0001099
GeneOntologyMolecularFunction	basal transcription machinery binding	NOLC1 NOP58 BRD4	3.36e-04	66	41	3	GO:0001098
GeneOntologyCellularComponent	box C/D RNP complex	NOLC1 NOP58 FBLL1	3.24e-07	7	45	3	GO:0170049
GeneOntologyCellularComponent	box C/D methylation guide snoRNP complex	NOLC1 NOP58 FBLL1	3.24e-07	7	45	3	GO:0031428
GeneOntologyCellularComponent	sno(s)RNA-containing ribonucleoprotein complex	NOLC1 NOP58 FBLL1	4.43e-05	32	45	3	GO:0005732
GeneOntologyCellularComponent	junctional membrane complex	JPH1 RYR1	1.62e-04	9	45	2	GO:0030314
GeneOntologyCellularComponent	junctional sarcoplasmic reticulum membrane	JPH1 RYR1	2.02e-04	10	45	2	GO:0014701
GeneOntologyCellularComponent	fibrillar center	NOLC1 NOP58 FBLL1 DUSP11	3.50e-04	156	45	4	GO:0001650
GeneOntologyCellularComponent	Cajal body	NOLC1 NOP58 FBLL1	7.86e-04	84	45	3	GO:0015030
GeneOntologyCellularComponent	pronucleus	BLM TET3	1.65e-03	28	45	2	GO:0045120
GeneOntologyCellularComponent	nuclear body	BLM NOLC1 NOP58 ERCC6 FBLL1 TRIP4 DUSP11	2.96e-03	903	45	7	GO:0016604
MousePheno	prolonged QRS complex duration	ING5 TBX3 VEGFA DUSP11	1.69e-05	73	30	4	MP:0010392
MousePheno	intraventricular block	ING5 TBX3 VEGFA DUSP11	1.79e-05	74	30	4	MP:0010560
MousePheno	bundle branch block	ING5 TBX3 VEGFA DUSP11	1.79e-05	74	30	4	MP:0010636
MousePheno	delayed heart development	TBX3 RYR1 VEGFA	4.24e-05	32	30	3	MP:0012082
MousePheno	abnormal skeletal muscle fiber triad morphology	JPH1 RYR1	4.43e-05	5	30	2	MP:0009411
MousePheno	absent endometrial glands	HOXA11 IGF2R	6.64e-05	6	30	2	MP:0009097
MousePheno	abnormal QRS complex	ING5 TBX3 VEGFA DUSP11	7.91e-05	108	30	4	MP:0003898
MousePheno	heart block	ING5 TBX3 VEGFA DUSP11	1.48e-04	127	30	4	MP:0010559
MousePheno	abnormal endometrial gland number	HOXA11 IGF2R	2.90e-04	12	30	2	MP:0009095
Domain	VCX/VCY1	VCX2 VCX3B VCX3A VCX	1.34e-10	5	44	4	IPR026653
Domain	VCX_VCY	VCX2 VCX3B VCX3A VCX	1.34e-10	5	44	4	PF15231
Domain	Homeobox_metazoa	HOXA11 NKX2-2 HMX1	1.24e-03	90	44	3	IPR020479
Domain	Helicase_C	BLM ERCC6 DDX54	2.04e-03	107	44	3	PF00271
Domain	HELICc	BLM ERCC6 DDX54	2.04e-03	107	44	3	SM00490
Domain	Helicase_C	BLM ERCC6 DDX54	2.10e-03	108	44	3	IPR001650
Domain	HELICASE_CTER	BLM ERCC6 DDX54	2.15e-03	109	44	3	PS51194
Domain	HELICASE_ATP_BIND_1	BLM ERCC6 DDX54	2.15e-03	109	44	3	PS51192
Domain	DEXDc	BLM ERCC6 DDX54	2.15e-03	109	44	3	SM00487
Domain	Helicase_ATP-bd	BLM ERCC6 DDX54	2.21e-03	110	44	3	IPR014001
Domain	EF-hand_8	EFCAB3 RYR1	2.90e-03	34	44	2	PF13833
Domain	Homeobox_CS	HOXA11 NKX2-2 HMX1	9.54e-03	186	44	3	IPR017970
Domain	Zinc_finger_PHD-type_CS	ING5 PHF2	1.03e-02	65	44	2	IPR019786
Pathway	REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS	FLT1 VEGFA	9.10e-05	8	26	2	M710
Pathway	REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS	FLT1 VEGFA	9.10e-05	8	26	2	MM14753
Pathway	PID_VEGF_VEGFR_PATHWAY	FLT1 VEGFA	1.46e-04	10	26	2	M137
Pubmed	A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation.	VCX2 VCX3B VCX3A VCX	2.68e-12	4	46	4	10903929
Pubmed	Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.	VCX2 VCX3B VCX3A	2.17e-09	3	46	3	18076704
Pubmed	A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.	VCX2 VCX3A VCX	2.16e-08	5	46	3	10607842
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ING5 JPH1 NOLC1 PHF2 TBX3 ERCC6 FBLL1 TAF13 TRIP4 BRD4 TFDP2	1.68e-07	1116	46	11	31753913
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ING5 BLM NOLC1 PHF2 HOXA11 TBX3 NOP58 TET3 BRD4 IWS1 DDX54	7.30e-07	1294	46	11	30804502
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ING5 BLM PHF2 NOP58 ERCC6 BRD4 IWS1 DDX54	1.21e-06	608	46	8	36089195
Pubmed	Effect of vegf gene knockdown on growth of the murine sarcoma cell line MS-K.	FLT1 VEGFA	1.71e-06	2	46	2	21501344
Pubmed	Immune cells regulate VEGF signalling via release of VEGF and antagonistic soluble VEGF receptor-1.	FLT1 VEGFA	1.71e-06	2	46	2	29235095
Pubmed	Prognostic impact of VEGF and FLT-1 receptor expression in patients with locally advanced squamous cell carcinoma of the head and neck.	FLT1 VEGFA	1.71e-06	2	46	2	23748230
Pubmed	The single-nucleotide polymorphisms +936 C/T VEGF and -710 C/T VEGFR1 are associated with breast cancer protection in a Spanish population.	FLT1 VEGFA	1.71e-06	2	46	2	22315135
Pubmed	[Relationship between the expression of vascular endothelial growth factor, fms-like tyrosine kinase-1 and biological behavior in gastric carcinoma].	FLT1 VEGFA	1.71e-06	2	46	2	17633783
Pubmed	Prognostic role of vascular endothelial growth factor and its receptor-1 in patients with esophageal cancer.	FLT1 VEGFA	1.71e-06	2	46	2	25202119
Pubmed	Greater free plasma VEGF and lower soluble VEGF receptor-1 in acute mountain sickness.	FLT1 VEGFA	1.71e-06	2	46	2	15649874
Pubmed	Modulation of neuritogenesis by a protein implicated in X-linked mental retardation.	VCX3B VCX3A	1.71e-06	2	46	2	19812318
Pubmed	Roles of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma.	FLT1 VEGFA	1.71e-06	2	46	2	29149180
Pubmed	Regulation of vascular endothelial growth factor-A and its soluble receptor sFlt-1 by luteinizing hormone in vivo: implication for ovarian follicle angiogenesis.	FLT1 VEGFA	1.71e-06	2	46	2	18343373
Pubmed	Angiogenic growth factors in maternal and fetal serum in pregnancies complicated with intrauterine growth restriction.	FLT1 VEGFA	1.71e-06	2	46	2	24484391
Pubmed	Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer.	FLT1 VEGFA	1.71e-06	2	46	2	10585578
Pubmed	Utility of VEGF and sVEGFR-1 in bronchoalveolar lavage fluid for differential diagnosis of primary lung cancer.	FLT1 VEGFA	1.71e-06	2	46	2	23725155
Pubmed	Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.	FLT1 VEGFA	1.71e-06	2	46	2	9393862
Pubmed	Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling.	FLT1 VEGFA	1.71e-06	2	46	2	18332870
Pubmed	Vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in septic shock patients treated with direct hemoperfusion with a polymyxin B-immobilized fiber column.	FLT1 VEGFA	1.71e-06	2	46	2	18789115
Pubmed	Upregulation of VEGF-A and correlation between VEGF-A and FLT-1 expressions in Iranian multiple sclerosis patients.	FLT1 VEGFA	1.71e-06	2	46	2	31925615
Pubmed	An increase in vascular endothelial growth factor (VEGF) and VEGF soluble receptor-1 (sFlt-1) are associated with early recurrent spontaneous abortion.	FLT1 VEGFA	1.71e-06	2	46	2	24098721
Pubmed	EBV‑LMP1 is involved in vasculogenic mimicry formation via VEGFA/VEGFR1 signaling in nasopharyngeal carcinoma.	FLT1 VEGFA	1.71e-06	2	46	2	29749553
Pubmed	The role of VEGF and its soluble receptor VEGFR-1 in preterm newborns of preeclamptic mothers with RDS.	FLT1 VEGFA	1.71e-06	2	46	2	23339636
Pubmed	Radiolabeling of VEGF165 with 99mTc to evaluate VEGFR expression in tumor angiogenesis.	FLT1 VEGFA	1.71e-06	2	46	2	28498441
Pubmed	Soluble vascular endothelial growth factor receptor-1 is reduced in patients with resistant hypertension after renal denervation.	FLT1 VEGFA	1.71e-06	2	46	2	27604660
Pubmed	Concentration of free vascular endothelial growth factor and its soluble receptor, sFlt-1 in the maternal and fetal circulations of normal term pregnancies at high and low altitudes.	FLT1 VEGFA	1.71e-06	2	46	2	22385323
Pubmed	High early uterine vascular resistance values increase the risk of adverse pregnancy outcome independently from placental VEGF and VEGFR1 reactivities.	FLT1 VEGFA	1.71e-06	2	46	2	21349629
Pubmed	A prospective, observational study of soluble FLT-1 and vascular endothelial growth factor in sepsis.	FLT1 VEGFA	1.71e-06	2	46	2	18598002
Pubmed	The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor.	FLT1 VEGFA	1.71e-06	2	46	2	1312256
Pubmed	Structure of the Full-length VEGFR-1 Extracellular Domain in Complex with VEGF-A.	FLT1 VEGFA	1.71e-06	2	46	2	28111021
Pubmed	Blockade of vascular endothelial growth factor suppresses experimental restenosis after intraluminal injury by inhibiting recruitment of monocyte lineage cells.	FLT1 VEGFA	1.71e-06	2	46	2	15477409
Pubmed	[Expression and clinical significance of vascular endothelial growth factor and its receptors in multiple myeloma].	FLT1 VEGFA	1.71e-06	2	46	2	17562275
Pubmed	Diabetes mellitus activates signal transduction pathways resulting in vascular endothelial growth factor resistance of human monocytes.	FLT1 VEGFA	1.71e-06	2	46	2	19564559
Pubmed	Ocular neovascularization caused by herpes simplex virus type 1 infection results from breakdown of binding between vascular endothelial growth factor A and its soluble receptor.	FLT1 VEGFA	1.71e-06	2	46	2	21325621
Pubmed	Association of VEGF and VEGFR1 polymorphisms with breast cancer risk in North Indians.	FLT1 VEGFA	1.71e-06	2	46	2	25604142
Pubmed	Absence of VEGFR-1/Flt-1 signaling pathway in mice results in insensitivity to discogenic low back pain in an established disc injury mouse model.	FLT1 VEGFA	1.71e-06	2	46	2	31875985
Pubmed	Time-course of sFlt-1 and VEGF-A release in neutropenic patients with sepsis and septic shock: a prospective study.	FLT1 VEGFA	1.71e-06	2	46	2	21371321
Pubmed	Bacterial antigen induced release of soluble vascular endothelial growth factor (VEGF) and VEGFR1 before and after surgery.	FLT1 VEGFA	1.71e-06	2	46	2	16095053
Pubmed	Angiogenic Imbalance and Residual Myocardial Injury in Recovered Peripartum Cardiomyopathy Patients.	FLT1 VEGFA	1.71e-06	2	46	2	28029641
Pubmed	Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis.	VCX3B VCX	1.71e-06	2	46	2	12862317
Pubmed	Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications.	FLT1 VEGFA	1.71e-06	2	46	2	25329693
Pubmed	Mechanical forces induce changes in VEGF and VEGFR-1/sFlt-1 expression in human chondrocytes.	FLT1 VEGFA	1.71e-06	2	46	2	25257525
Pubmed	Vascular endothelial growth factor (VEGF) and soluble VEGF receptor FLT-1 in diabetic nephropathy.	FLT1 VEGFA	1.71e-06	2	46	2	15610240
Pubmed	Expression of vascular endothelial growth factor (VEGF) and its soluble receptor-1 in endometriosis.	FLT1 VEGFA	1.71e-06	2	46	2	22230112
Pubmed	Vascular Endothelial Growth Factor Receptor, fms-Like Tyrosine Kinase-1 (Flt-1), as a Novel Binding Partner for SARS-CoV-2 Spike Receptor-Binding Domain.	FLT1 VEGFA	1.71e-06	2	46	2	35874709
Pubmed	Prediction of adverse perinatal outcome and the mean time until delivery in twin pregnancies with suspected pre-eclampsia using sFlt-1/PIGF ratio.	FLT1 VEGFA	1.71e-06	2	46	2	33647841
Pubmed	Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding.	FLT1 VEGFA	1.71e-06	2	46	2	11513746
Pubmed	VEGF-A induces its negative regulator, soluble form of VEGFR-1, by modulating its alternative splicing.	FLT1 VEGFA	1.71e-06	2	46	2	23711375
Pubmed	Vascular endothelial growth factor and signaling in the prostate: more than angiogenesis.	FLT1 VEGFA	1.71e-06	2	46	2	12039075
Pubmed	Circulating levels of VEGF-A, VEGF-D and soluble VEGF-A receptor (sFIt-1) in human breast cancer.	FLT1 VEGFA	1.71e-06	2	46	2	15503825
Pubmed	Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport.	FLT1 VEGFA	1.71e-06	2	46	2	19351908
Pubmed	Serum VEGF-A and VEGFR-1 levels in patients with adult immunoglobulin A vasculitis.	FLT1 VEGFA	1.71e-06	2	46	2	33890417
Pubmed	Hypoxia regulates vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts.	FLT1 VEGFA	1.71e-06	2	46	2	16616080
Pubmed	Functional significance of vascular endothelial growth factor and its receptor (receptor-1) in various lung cancer types.	FLT1 VEGFA	1.71e-06	2	46	2	15329326
Pubmed	Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt1 receptor.	FLT1 VEGFA	1.71e-06	2	46	2	12406876
Pubmed	Characterization of the VEGF binding site on the Flt-1 receptor.	FLT1 VEGFA	1.71e-06	2	46	2	10471394
Pubmed	The relationship of serum VEGF and sVEGFR-1 levels with vascular involvement in patients with Behçet's disease.	FLT1 VEGFA	1.71e-06	2	46	2	30015524
Pubmed	VEGFR1 expression is related to lymph node metastasis and serum VEGF may be a marker of progression in the follow-up of patients with differentiated thyroid carcinoma.	FLT1 VEGFA	1.71e-06	2	46	2	21097568
Pubmed	Vascular endothelial growth factor, fms-like tyrosine kinase-1 (Flt-1) and soluble Flt-1 gene expressions in Korean pre-eclamptic placentas.	FLT1 VEGFA	1.71e-06	2	46	2	20666936
Pubmed	Brain angiogenic gene expression in fetuses with congenital heart disease.	FLT1 VEGFA	1.71e-06	2	46	2	29205570
Pubmed	Different activity of the biological axis VEGF-Flt-1 (fms-like tyrosine kinase 1) and CXC chemokines between pulmonary sarcoidosis and idiopathic pulmonary fibrosis: a bronchoalveolar lavage study.	FLT1 VEGFA	1.71e-06	2	46	2	20169144
Pubmed	Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.	FLT1 VEGFA	1.71e-06	2	46	2	10543948
Pubmed	Increased mRNA expression of vascular endothelial growth factor and its receptor (flt-1) in the hydrosalpinx.	FLT1 VEGFA	1.71e-06	2	46	2	14585871
Pubmed	Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis.	FLT1 VEGFA	1.71e-06	2	46	2	19324337
Pubmed	VEGF-A and VEGFR1 SNPs associate with preeclampsia in a Philippine population.	FLT1 VEGFA	1.71e-06	2	46	2	27668980
Pubmed	Multiparity increases trophoblast invasion and vascular endothelial growth factor expression at the maternal-fetal interface in mice.	FLT1 VEGFA	1.71e-06	2	46	2	20462640
Pubmed	Comparison of serum VEGF and its soluble receptor sVEGFR1 with serum cell-free DNA in patients with breast tumor.	FLT1 VEGFA	1.71e-06	2	46	2	18691902
Pubmed	Biological variations in plasma VEGF and VEGFR-1 may compromise their biomarker value in colorectal cancer.	FLT1 VEGFA	1.71e-06	2	46	2	20873967
Pubmed	Vascular Endothelial Growth Factor (VEGF) and soluble VEGF receptor 1 (sFlt-1) levels in early and mature human milk from mothers of preterm versus term infants.	FLT1 VEGFA	1.71e-06	2	46	2	22729710
Pubmed	[Expression of vascular endothelial growth factor and its receptor (Flt-1) in breast carcinoma].	FLT1 VEGFA	1.71e-06	2	46	2	12133473
Pubmed	Angiogenic and Antiangiogenic Factors in Preterm Neonates Born to Mothers with and without Preeclampsia.	FLT1 VEGFA	1.71e-06	2	46	2	26007312
Pubmed	Expression of vascular endothelial growth factor-A and its receptor-1 in a luteal endometrium in patients with repeated in vitro fertilization failure.	FLT1 VEGFA	1.71e-06	2	46	2	18295763
Pubmed	Both vascular endothelial growth factor and soluble Flt-1 are increased in type 2 diabetes but not in impaired fasting glucose.	FLT1 VEGFA	1.71e-06	2	46	2	20571438
Pubmed	[Association of polymorphisms of VEGF and VEGFR1 pathways related genes and risk of pre-eclampsia].	FLT1 VEGFA	1.71e-06	2	46	2	35929944
Pubmed	Vascular endothelial growth factor and its soluble receptor in patients with polycystic ovary syndrome undergoing IVF.	FLT1 VEGFA	1.71e-06	2	46	2	19330612
Pubmed	Relationship among VEGF, VEGF receptor, AGEs, and macrophages in proliferative diabetic retinopathy.	FLT1 VEGFA	1.71e-06	2	46	2	18053608
Pubmed	Expression of VEGF and its receptor genes in intracranial schwannomas.	FLT1 VEGFA	1.71e-06	2	46	2	17570036
Pubmed	The ratio of membrane-bound form Flt-1 mRNA to VEGF mRNA correlates with tumor angiogenesis and prognosis in non-small cell lung cancer.	FLT1 VEGFA	1.71e-06	2	46	2	16530326
Pubmed	Systemic production of vascular endothelial growth factor and fms-like tyrosine kinase-1 receptor in acute Kawasaki disease.	FLT1 VEGFA	1.71e-06	2	46	2	11839635
Pubmed	Circulating levels of vascular endothelial growth factor A and its soluble receptor in patients with biopsy-proven nonalcoholic fatty liver disease.	FLT1 VEGFA	1.71e-06	2	46	2	21376261
Pubmed	Flt-1 (vascular endothelial growth factor receptor-1) is essential for the vascular endothelial growth factor-Notch feedback loop during angiogenesis.	FLT1 VEGFA	1.71e-06	2	46	2	23744993
Pubmed	A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap.	FLT1 VEGFA	1.71e-06	2	46	2	19352513
Pubmed	Increased plasma levels of soluble vascular endothelial growth factor receptor 1 (sFlt-1) in women by moderate exercise and increased plasma levels of vascular endothelial growth factor in overweight/obese women.	FLT1 VEGFA	1.71e-06	2	46	2	22609636
Pubmed	Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery.	FLT1 VEGFA	1.71e-06	2	46	2	20606119
Pubmed	VEGF-A selectively inhibits FLT1 ectodomain shedding independent of receptor activation and receptor endocytosis.	FLT1 VEGFA	1.71e-06	2	46	2	29719170
Pubmed	VEGF mediated signaling in oral cancer.	FLT1 VEGFA	1.71e-06	2	46	2	28145862
Pubmed	Serum vascular endothelial growth factor/soluble vascular endothelial growth factor receptor 1 ratio is an independent prognostic marker in pancreatic cancer.	FLT1 VEGFA	1.71e-06	2	46	2	18665074
Pubmed	Vascular endothelial growth factor and its soluble receptor in benign and malignant ovarian tumors.	FLT1 VEGFA	1.71e-06	2	46	2	18037256
Pubmed	VEGF and VEGFR1 levels in different regions of the normal and preeclampsia placentae.	FLT1 VEGFA	1.71e-06	2	46	2	28770473
Pubmed	Motor neurons control blood vessel patterning in the developing spinal cord.	FLT1 NKX2-2 VEGFA	2.83e-06	21	46	3	28262664
Pubmed	Endothelial cell signature in muscle stem cells validated by VEGFA-FLT1-AKT1 axis promoting survival of muscle stem cell.	FLT1 VEGFA	5.13e-06	3	46	2	38842166
Pubmed	Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis.	FLT1 VEGFA	5.13e-06	3	46	2	7683699
Pubmed	The expression of VEGF receptor genes is concurrently influenced by epigenetic gene silencing of the genes and VEGF activation.	FLT1 VEGFA	5.13e-06	3	46	2	19633424
Pubmed	Analysis of circulating vascular endothelial growth factor and its soluble receptors in patients with different forms of chronic urticaria.	FLT1 VEGFA	5.13e-06	3	46	2	25756047
Pubmed	VEGF-A165 induces human aortic smooth muscle cell migration by activating neuropilin-1-VEGFR1-PI3K axis.	FLT1 VEGFA	5.13e-06	3	46	2	18284215
Pubmed	Vimentin is synthesized by mouse vascular trophoblast giant cells from embryonic day 7.5 onwards and is a characteristic factor of these cells.	FLT1 VEGFA	5.13e-06	3	46	2	23664004
Pubmed	A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network.	FLT1 VEGFA	5.13e-06	3	46	2	16432214
Interaction	NOP56 interactions	BLM NOLC1 PHF2 NOP58 ERCC6 ARHGAP36 BRD4 DDX54	2.81e-05	570	44	8	int:NOP56
Interaction	FLT1 interactions	BLM FLT1 BTK VEGFA DDX54	4.29e-05	179	44	5	int:FLT1
Interaction	DDX23 interactions	NOLC1 PHF2 NOP58 ERCC6 BRD4 IWS1 DDX54	7.44e-05	480	44	7	int:DDX23
Interaction	POLR1G interactions	BLM NOLC1 PHF2 NOP58 BRD4 IWS1 DDX54	8.35e-05	489	44	7	int:POLR1G
Interaction	RPL31 interactions	BLM NOLC1 PHF2 BTF3L4 NOP58 BRD4 IWS1 DDX54	9.75e-05	680	44	8	int:RPL31
Interaction	POLR1E interactions	BLM NOLC1 PHF2 NOP58 BRD4 DDX54	1.06e-04	350	44	6	int:POLR1E
Interaction	POLR1A interactions	NOLC1 NOP58 ERCC6 TAF13 BRD4	1.14e-04	220	44	5	int:POLR1A
Interaction	IWS1 interactions	NOLC1 ERCC6 BRD4 IWS1	1.18e-04	116	44	4	int:IWS1
Interaction	PRKACA interactions	JPH1 MEP1B NOLC1 IGF2R TNP1 ARHGAP36 RYR1	1.21e-04	519	44	7	int:PRKACA
Interaction	CAMKV interactions	JPH1 NOLC1 TNRC18 BRD4	1.27e-04	118	44	4	int:CAMKV
Interaction	PGF interactions	FLT1 VEGFA	1.29e-04	8	44	2	int:PGF
Interaction	RPS24 interactions	BLM NOLC1 PHF2 NOP58 ERCC6 BRD4 DDX54	1.36e-04	529	44	7	int:RPS24
Interaction	CSNK2A1 interactions	NOLC1 BTF3L4 NOP58 IGF2R TNP1 ARHGAP36 BRD4 IWS1 DDX54	1.85e-04	956	44	9	int:CSNK2A1
Cytoband	Ensembl 112 genes in cytogenetic band chrXp22	VCX2 VCX3B VCX3A VCX	1.17e-04	250	46	4	chrXp22
Cytoband	Xp22	VCX3A VCX	2.90e-04	25	46	2	Xp22
Cytoband	2p13.1	TET3 DUSP11	5.40e-04	34	46	2	2p13.1
GeneFamily	Variable charge X/Y family	VCX2 VCX3B VCX3A VCX	1.06e-10	6	31	4	368
GeneFamily	NKL subclass homeoboxes and pseudogenes	NKX2-2 HMX1	5.87e-03	67	31	2	519
GeneFamily	PHD finger proteins	ING5 PHF2	1.04e-02	90	31	2	88
Coexpression	GSE40274_CTRL_VS_GATA1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN	IGF2R TAF13 IWS1 VEGFA DDX54	1.13e-05	172	45	5	M9099
Coexpression	GSE3982_NEUTROPHIL_VS_NKCELL_UP	HOXA11 TBX3 TNP1 BRD4 BTK	2.29e-05	199	45	5	M5530
Drug	cornin iridoid	FLT1 VEGFA	3.99e-06	2	46	2	ctd:C000511
Disease	allergic contact dermatitis (is_marker_for)	FLT1 VEGFA	6.51e-06	3	44	2	DOID:3042 (is_marker_for)
Disease	arteriovenous malformations of the brain (is_marker_for)	FLT1 VEGFA	6.51e-06	3	44	2	DOID:0060688 (is_marker_for)
Disease	melanoma (is_marker_for)	FLT1 BRD4 VEGFA	1.64e-05	33	44	3	DOID:1909 (is_marker_for)
Disease	Abnormality of the face	TET3 BRD4	7.77e-05	9	44	2	C4025871
Disease	colorectal cancer (is_marker_for)	TBX3 ERCC6 BTK VEGFA	8.87e-05	157	44	4	DOID:9256 (is_marker_for)
Disease	triglycerides in medium LDL measurement	RSPO3 IGF2R VEGFA	1.10e-04	62	44	3	EFO_0022322
Disease	Microphthalmos	ERCC6 HMX1	1.19e-04	11	44	2	C0026010
Disease	cholesterol in large VLDL measurement	RSPO3 IGF2R VEGFA	1.27e-04	65	44	3	EFO_0021902
Disease	cholesterol in very large VLDL measurement	RSPO3 IGF2R VEGFA	1.27e-04	65	44	3	EFO_0022230
Disease	macular retinal edema (is_marker_for)	FLT1 VEGFA	1.42e-04	12	44	2	DOID:4449 (is_marker_for)
Disease	BMI-adjusted waist-hip ratio, physical activity measurement	HOXA11 RSPO3 VEGFA	1.51e-04	69	44	3	EFO_0007788, EFO_0008002
Disease	Schwartz-Jampel Syndrome, Type 1	FLT1 VEGFA	2.57e-04	16	44	2	C4551479
Disease	Spondyloepiphyseal Dysplasia	FLT1 VEGFA	2.57e-04	16	44	2	C0038015
Disease	Schwartz-Jampel Syndrome	FLT1 VEGFA	2.57e-04	16	44	2	C0036391
Disease	Melnick-Needles Syndrome	FLT1 VEGFA	2.57e-04	16	44	2	C0025237
Disease	Spondyloepiphyseal Dysplasia Tarda, X-Linked	FLT1 VEGFA	2.57e-04	16	44	2	C3541456
Disease	smoking behavior, BMI-adjusted waist-hip ratio	HOXA11 RSPO3 VEGFA	2.90e-04	86	44	3	EFO_0004318, EFO_0007788
Disease	Van Buchem disease	FLT1 VEGFA	2.91e-04	17	44	2	C0432272
Disease	Limb Deformities, Congenital	HOXA11 TBX3	2.91e-04	17	44	2	C0206762
Disease	Kuhnt-Junius degeneration (is_implicated_in)	FLT1 VEGFA	2.91e-04	17	44	2	DOID:10873 (is_implicated_in)
Disease	very low density lipoprotein cholesterol measurement, lipid measurement	RSPO3 IGF2R TAF13 VEGFA	3.23e-04	220	44	4	EFO_0004529, EFO_0008317
Disease	Hemangiosarcoma	FLT1 VEGFA	3.27e-04	18	44	2	C0018923
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	RSPO3 IGF2R TAF13 VEGFA	3.46e-04	224	44	4	EFO_0004530, EFO_0008317
Disease	Dyschondroplasias	FLT1 VEGFA	3.66e-04	19	44	2	C0013366
Disease	Osteochondrodysplasias	FLT1 VEGFA	3.66e-04	19	44	2	C0029422
Disease	very low density lipoprotein cholesterol measurement, phospholipid measurement	RSPO3 IGF2R TAF13 VEGFA	3.76e-04	229	44	4	EFO_0004639, EFO_0008317
Disease	Multiple Epiphyseal Dysplasia	FLT1 VEGFA	4.06e-04	20	44	2	C0026760
Disease	BMI-adjusted waist-hip ratio, sex interaction measurement, age at assessment	HOXA11 RSPO3 VEGFA	5.22e-04	105	44	3	EFO_0007788, EFO_0008007, EFO_0008343
Disease	very low density lipoprotein cholesterol measurement	RSPO3 IGF2R TAF13 VEGFA	6.06e-04	260	44	4	EFO_0008317
Disease	pre-eclampsia (is_implicated_in)	FLT1 VEGFA	6.38e-04	25	44	2	DOID:10591 (is_implicated_in)
Disease	creatinine measurement, glomerular filtration rate	ASTN2 TFDP2 VEGFA	7.15e-04	117	44	3	EFO_0004518, EFO_0005208
Disease	visceral adipose tissue measurement	PHF2 RSPO3 ULK4 ARPP21 VEGFA	7.25e-04	481	44	5	EFO_0004765
Disease	Cerebral Hemorrhage	FLT1 VEGFA	8.01e-04	28	44	2	C2937358
Disease	smoking behavior, BMI-adjusted waist circumference	HOXA11 RSPO3 VEGFA	8.07e-04	122	44	3	EFO_0004318, EFO_0007789
Disease	BMI-adjusted waist circumference, physical activity measurement	HOXA11 RSPO3 VEGFA	8.26e-04	123	44	3	EFO_0007789, EFO_0008002
Disease	abdominal:gluteofemoral adipose tissue ratio measurement	RSPO3 VEGFA	8.60e-04	29	44	2	EFO_0803320
Disease	Age related macular degeneration	ERCC6 VEGFA	9.21e-04	30	44	2	C0242383
Disease	Malignant neoplasm of breast	RSPO3 ASTN2 TBX3 FLT1 TBC1D9B ERCC6 BTK	9.79e-04	1074	44	7	C0006142
Disease	atrial fibrillation (is_marker_for)	FLT1 VEGFA	1.05e-03	32	44	2	DOID:0060224 (is_marker_for)
Disease	unipolar depression, mood disorder	PHF2 ASTN2 ARPP21	1.06e-03	134	44	3	EFO_0003761, EFO_0004247
Disease	triglyceride measurement, physical activity	RSPO3 VEGFA	1.18e-03	34	44	2	EFO_0003940, EFO_0004530
Disease	creatinine measurement, chronic kidney disease	TFDP2 VEGFA	1.25e-03	35	44	2	EFO_0003884, EFO_0004518
Disease	hippocampal CA3 volume	ASTN2 TFDP2	1.33e-03	36	44	2	EFO_0009395

Protein segments in the cluster

Peptide	Gene	Start	Entry
AKGRGRGRKETGTAK	BRD4	176	O60885
RGRRGSKKGSIDVEK	BTK	46	Q06187
SGAPAGKKSRFGKKR	ERCC6	1321	Q03468
VTRSRNGGKGKGKKS	ARMCX2	286	Q7L311
QERRKSKSGAGKGKL	ARPP21	51	Q9UBL0
KRKRRSKSRGGISFG	ASTN2	381	O75129
RHEKTKKKRGSYRGG	NOLC1	671	Q14978
GKFGKRESRKTKLGI	ARHGAP36	391	Q6ZRI8
KKSMSGKRRRNRDGG	IWS1	536	Q96ST2
RGIRKISGTGKALAK	NOP58	401	Q9Y2X3
KKRQHGGDEGSRSRK	LENG1	166	Q96BZ8
DGSFRNLKKKDRGVG	LRRC53	396	A6NM62
AELAGKKKGGLFRRG	JPH1	201	Q9HDC5
FGRGARSKKGKMRKR	DDX54	866	Q8TDD1
RGGVAKSKSRRRKGA	FBLL1	81	A6NHQ2
YGEKRRGGKKRKTHQ	PDZD2	96	O15018
GDRTAKKGKRTRKFG	PDZD2	206	O15018
VGVGGGRKKKTRTVF	HMX1	196	Q9NP08
DKAGGSSGQRTRKKR	HOXA11	231	P31270
GRGVQHTDKRKKKGR	TTC26	11	A0AVF1
KRRKTASSGSKAKGG	BLM	1346	P54132
RRDFSGRSSAKKKGG	DUSP11	61	O75319
GGKGTARRKKKVVHR	BTF3L4	16	Q96K17
RGLKKGRGQKEKRGS	ING5	126	Q8WYH8
YTDSGRKRKRKGLKG	EFCAB3	421	Q8N7B9
SGGSDQERTKKKRRG	RYR1	3486	P21817
KKFRVVFEGRKGSGA	MEP1B	396	Q16820
VGLVRGEKARKGKSS	IGF2R	2451	P11717
RRGRRGKKGAATKMA	VCX3A	46	Q9NNX9
RRGRRGKKGAATKMA	VCX3B	46	Q9H321
KGFRDTGNGRREKRK	TBX3	301	O15119
GSGKSAGKRLLKRAA	PHF2	836	O75151
KGRKDVQKTGFRSSG	SPATA31E1	686	Q6ZUB1
GGGDAGKKRKRRVLF	NKX2-2	121	O95096
AEGGQGKRKRLFSKE	TAF13	21	Q15543
RSKKGDKNGKGLRHF	TFDP2	121	Q14188
IGEVGKKFSARTGRK	TBC1D9B	1061	Q66K14
GRGRKPSAKAKGDRA	TNRC18	2331	O15417
RRGRRGKKGAATKMA	VCX2	46	Q9H322
RGGSKRKYRKGNLKS	TNP1	26	P09430
TAAGKGKGEARARLK	SMTNL2	326	Q2TAL5
KKGKTCGFKRGTETR	RSPO3	161	Q9BXY4
ESQLRGGGDGRKKRK	TET3	41	O43151
RRGRRGKKGAATKMA	VCX	46	Q9H320
QKSGDHLKRGRKKGR	TRIP4	96	Q15650
RARQEKKSVRGKGKG	VEGFA	136	P15692
RLKLGKSLGRGAFGK	FLT1	826	P17948
GRGSKTVVYKGRRKG	ULK4	11	Q96C45