Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioniron-responsive element binding

ACO1 IREB2

1.67e-0431502GO:0030350
GeneOntologyMolecularFunctionaconitate hydratase activity

ACO1 IREB2

1.67e-0431502GO:0003994
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

PLXNA3 CUX2 FN1 MYO7A CNTNAP1 LAMA2 CDH23 ALS2 TECTA TTC3 ADARB1 ZEB2 ANOS1 SLITRK2 LRP2 CDC42 PLXNA1 RAC1 RAC3

2.19e-0674815019GO:0048667
GeneOntologyBiologicalProcesspositive regulation of lamellipodium assembly

MTOR CDC42 RAC1 RAC2 PLCE1

3.27e-06321505GO:0010592
GeneOntologyBiologicalProcessembryonic morphogenesis

MYH3 COL12A1 FN1 MYO7A HYAL1 HIPK2 CDH23 MED1 TECTA ZEB2 CRYAA SETD2 HOXC11 ALX1 LRP2 PAX3 TMEM231 RAC1

4.50e-0671315018GO:0048598
GeneOntologyBiologicalProcessanimal organ morphogenesis

KLHL10 SDK2 MYO7A HYAL1 HIPK2 LAMA2 POR CDH23 MED1 TECTA ADARB1 STAT3 CRYAA SETD2 HOXC11 ALX1 CSF3R MTOR LRP2 PAX3 CDC42 NOS3 PLXNA1 RAC1 FBXW11

4.86e-06126915025GO:0009887
GeneOntologyBiologicalProcesspositive regulation of lamellipodium organization

MTOR CDC42 RAC1 RAC2 PLCE1

1.02e-05401505GO:1902745
GeneOntologyBiologicalProcesscell morphogenesis

PLXNA3 KLHL10 CUX2 FN1 MYO7A CNTNAP1 LAMA2 CDH23 ALS2 MED1 TECTA TTC3 ADARB1 ZEB2 CRYAA ANOS1 SLITRK2 LRP2 CDC42 CDH10 PLXNA1 RAC1 RAC3

1.75e-05119415023GO:0000902
GeneOntologyBiologicalProcessregulation of lamellipodium assembly

MTOR CDC42 RAC1 RAC2 PLCE1

1.84e-05451505GO:0010591
GeneOntologyBiologicalProcessenucleate erythrocyte development

MED1 RAC1 RAC2

2.06e-0581503GO:0048822
GeneOntologyBiologicalProcessmulti-pass transmembrane protein insertion into ER membrane

NOMO1 NOMO2 NOMO3

3.07e-0591503GO:0160063
GeneOntologyBiologicalProcessneuromuscular process

MYH3 MYO7A CNTNAP1 HIPK2 CDH23 PNKD ADARB1 MTOR RAC3

4.09e-052251509GO:0050905
GeneOntologyBiologicalProcessolfactory nerve formation

PLXNA3 PLXNA1

5.25e-0521502GO:0021628
GeneOntologyBiologicalProcessneuron projection development

PLXNA3 CUX2 FN1 HTR7 MYO7A CNTNAP1 LAMA2 CDH23 NCAM2 ALS2 TECTA TTC3 MAPKAPK5 ADARB1 ZEB2 ANOS1 SLITRK2 MTOR LRP2 CDC42 PLXNA1 RAC1 RAC3

5.50e-05128515023GO:0031175
GeneOntologyBiologicalProcessregulation of lamellipodium organization

MTOR CDC42 RAC1 RAC2 PLCE1

5.87e-05571505GO:1902743
GeneOntologyBiologicalProcessaxonogenesis

PLXNA3 FN1 CNTNAP1 LAMA2 ALS2 TTC3 ADARB1 ZEB2 ANOS1 SLITRK2 LRP2 PLXNA1 RAC1 RAC3

6.86e-0556615014GO:0007409
GeneOntologyBiologicalProcessaxon development

PLXNA3 FN1 CNTNAP1 LAMA2 NCAM2 ALS2 TTC3 ADARB1 ZEB2 ANOS1 SLITRK2 LRP2 PLXNA1 RAC1 RAC3

7.11e-0564215015GO:0061564
GeneOntologyBiologicalProcessauditory receptor cell morphogenesis

MYO7A CDH23 TECTA RAC1

7.26e-05311504GO:0002093
GeneOntologyBiologicalProcesscentral nervous system neuron development

PLXNA3 ADARB1 ZEB2 PLXNA1 RAC1 RAC3

8.60e-05991506GO:0021954
GeneOntologyBiologicalProcessstem cell development

FN1 ZEB2 SETD2 ALX1 PAX3 CDC42

9.61e-051011506GO:0048864
GeneOntologyBiologicalProcessolfactory nerve morphogenesis

PLXNA3 PLXNA1

1.57e-0431502GO:0021627
GeneOntologyBiologicalProcessanatomical structure formation involved in morphogenesis

PLXNA3 MYH3 SDK2 COL12A1 FN1 HYAL1 RC3H1 SOX30 CNTNAP1 HIPK2 MED1 ZEB2 STAT3 SETD2 OR10J5 HOXC11 ALX1 CSF3R LRP2 PAX3 CDC42 NOS3 PLXNA1 KNL1

1.77e-04148315024GO:0048646
GeneOntologyBiologicalProcessenucleate erythrocyte differentiation

MED1 RAC1 RAC2

1.97e-04161503GO:0043353
GeneOntologyBiologicalProcessauditory receptor cell development

MYO7A CDH23 TECTA RAC1

2.00e-04401504GO:0060117
GeneOntologyBiologicalProcessembryonic organ development

A2M MYO7A HYAL1 HIPK2 CDH23 MED1 TECTA CRYAA SETD2 HOXC11 ALX1 CDC42 RAC1

2.38e-0456115013GO:0048568
GeneOntologyBiologicalProcessneuron projection morphogenesis

PLXNA3 CUX2 FN1 CNTNAP1 LAMA2 ALS2 TTC3 ADARB1 ZEB2 ANOS1 SLITRK2 LRP2 CDC42 PLXNA1 RAC1 RAC3

2.50e-0480215016GO:0048812
GeneOntologyBiologicalProcessembryonic organ morphogenesis

MYO7A HYAL1 HIPK2 CDH23 TECTA CRYAA SETD2 HOXC11 ALX1 RAC1

2.55e-0435115010GO:0048562
GeneOntologyBiologicalProcessrespiratory burst

MPO RAC1 RAC2 RAC3

2.66e-04431504GO:0045730
GeneOntologyBiologicalProcesslamellipodium assembly

MTOR CDC42 RAC1 RAC2 PLCE1

2.78e-04791505GO:0030032
GeneOntologyBiologicalProcessregulation of neuron maturation

MTOR RAC1 RAC3

2.84e-04181503GO:0014041
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

PLXNA3 CUX2 FN1 CNTNAP1 LAMA2 ALS2 TTC3 ADARB1 ZEB2 ANOS1 SLITRK2 LRP2 CDC42 PLXNA1 RAC1 RAC3

3.16e-0481915016GO:0120039
GeneOntologyBiologicalProcesspositive regulation of cellular component biogenesis

CUX2 HYAL1 ADGRL1 DHX33 ARHGEF15 DRG1 SLITRK2 MTOR CDC42 RAC1 MPP7 RAC2 PLCE1

3.38e-0458215013GO:0044089
GeneOntologyBiologicalProcesscell projection morphogenesis

PLXNA3 CUX2 FN1 CNTNAP1 LAMA2 ALS2 TTC3 ADARB1 ZEB2 ANOS1 SLITRK2 LRP2 CDC42 PLXNA1 RAC1 RAC3

3.47e-0482615016GO:0048858
GeneOntologyBiologicalProcessneuron development

PLXNA3 CUX2 FN1 HTR7 MYO7A CNTNAP1 LAMA2 CDH23 NCAM2 ALS2 TECTA TTC3 MAPKAPK5 ADARB1 ZEB2 ANOS1 SLITRK2 MTOR LRP2 CDC42 PLXNA1 RAC1 RAC3

3.71e-04146315023GO:0048666
GeneOntologyBiologicalProcessstem cell differentiation

A2M FN1 MED1 ZEB2 STAT3 SETD2 ALX1 PAX3 CDC42

4.13e-043061509GO:0048863
GeneOntologyBiologicalProcesshomeostasis of number of cells within a tissue

KLHL10 NOS3 RAC1 RAC3

5.15e-04511504GO:0048873
GeneOntologyBiologicalProcesscitrate metabolic process

ACO1 IREB2

5.18e-0451502GO:0006101
GeneOntologyBiologicalProcesspositive regulation of small molecule metabolic process

CD244 POR STAT3 PPP4R3B MTOR PRKAA1 NOS3

5.21e-041921507GO:0062013
GeneOntologyBiologicalProcessneuromuscular process controlling posture

CNTNAP1 PNKD ADARB1

5.25e-04221503GO:0050884
GeneOntologyCellularComponentmulti-pass translocon complex

NOMO1 NOMO2 NOMO3

3.07e-0591523GO:0160064
GeneOntologyCellularComponentER membrane insertion complex

NOMO1 NOMO2 NOMO3

1.29e-04141523GO:0072379
GeneOntologyCellularComponentNADPH oxidase complex

RAC1 RAC2 RAC3

2.84e-04181523GO:0043020
DomainDUF2012

NOMO1 NOMO2 NOMO3

1.98e-0641493PF09430
DomainDUF2012

NOMO1 NOMO2 NOMO3

1.98e-0641493IPR019008
DomainCarboxyPept_regulatory_dom

NOMO1 NOMO2 CPXM1 NOMO3

2.63e-06131494IPR014766
Domain-

NOMO1 NOMO2 CPXM1 NOMO3

2.63e-061314942.60.40.1120
DomainCarboxyPept-like_regulatory

NOMO1 NOMO2 CPXM1 NOMO3

8.54e-06171494IPR008969
DomainRHO

CDC42 RAC1 RAC2 RAC3

1.71e-05201494PS51420
DomainCarb-bd-like_fold

NOMO1 NOMO2 NOMO3

2.71e-0581493IPR013784
DomainAconitase/IRP2

ACO1 IREB2

6.32e-0521492IPR006249
DomainAconitaseA/IPMdHydase_ssu_swvl

ACO1 IREB2

1.89e-0431492IPR000573
DomainAconitase_C

ACO1 IREB2

1.89e-0431492PF00694
Domain-

ACO1 IREB2

1.89e-04314923.30.499.10
DomainAcoase/IPM_deHydtase_lsu_aba

ACO1 IREB2

1.89e-0431492IPR001030
Domain-

ACO1 IREB2

1.89e-04314923.40.1060.10
Domain-

ACO1 IREB2

1.89e-04314923.20.19.10
DomainAcoase/IPM_deHydtase

ACO1 IREB2

1.89e-0431492IPR015937
DomainAcnase/IPM_dHydase_lsu_aba_1/3

ACO1 IREB2

1.89e-0431492IPR015931
DomainAconitase/IPMdHydase_lsu_aba_2

ACO1 IREB2

1.89e-0431492IPR015932
DomainACONITASE_1

ACO1 IREB2

1.89e-0431492PS00450
DomainAconitase/3IPM_dehydase_swvl

ACO1 IREB2

1.89e-0431492IPR015928
DomainAconitase

ACO1 IREB2

1.89e-0431492PF00330
DomainAconitase_4Fe-4S_BS

ACO1 IREB2

1.89e-0431492IPR018136
DomainACONITASE_2

ACO1 IREB2

1.89e-0431492PS01244
DomainFAD_binding_1

POR NOS3

9.29e-0461492PF00667
Domain-

POR NOS3

9.29e-04614921.20.990.10
DomainFAD-binding_1

POR NOS3

9.29e-0461492IPR003097
DomainNADPH_Cyt_P450_Rdtase_dom3

POR NOS3

9.29e-0461492IPR023173
DomainFN3

SDK2 COL12A1 FN1 IL20RA NCAM2 ANOS1 CSF3R

1.10e-031991497PS50853
DomainSTAT_TF_DNA-bd_sub

STAT2 STAT3

1.29e-0371492IPR012345
DomainSTAT

STAT2 STAT3

1.29e-0371492IPR001217
DomainSTAT_int

STAT2 STAT3

1.29e-0371492SM00964
DomainSTAT_TF_DNA-bd

STAT2 STAT3

1.29e-0371492IPR013801
DomainSTAT_bind

STAT2 STAT3

1.29e-0371492PF02864
DomainSTAT_int

STAT2 STAT3

1.29e-0371492PF02865
Domain-

STAT2 STAT3

1.29e-03714921.10.532.10
DomainSTAT_alpha

STAT2 STAT3

1.29e-0371492PF01017
Domain-

STAT2 STAT3

1.29e-03714921.20.1050.20
DomainSTAT_TF_prot_interaction

STAT2 STAT3

1.29e-0371492IPR013799
DomainSTAT_TF_coiled-coil

STAT2 STAT3

1.29e-0371492IPR015988
Domain-

STAT2 STAT3

1.29e-03714922.60.40.630
DomainFN3_dom

SDK2 COL12A1 FN1 IL20RA NCAM2 ANOS1 CSF3R

1.46e-032091497IPR003961
DomainFlavodoxin/NO_synth

POR NOS3

1.72e-0381492IPR008254
DomainSTAT_TF_alpha

STAT2 STAT3

1.72e-0381492IPR013800
DomainFlavdoxin-like

POR NOS3

1.72e-0381492IPR001094
Domain-

TMEM131 HYDIN

1.72e-03814922.60.40.360
DomainFLAVODOXIN_LIKE

POR NOS3

1.72e-0381492PS50902
DomainFlavodoxin_1

POR NOS3

1.72e-0381492PF00258
Domainfn3

SDK2 COL12A1 FN1 NCAM2 ANOS1 CSF3R

1.92e-031621496PF00041
DomainPlexin_cytopl

PLXNA3 PLXNA1

2.19e-0391492PF08337
DomainPapD-like

TMEM131 HYDIN

2.19e-0391492IPR008962
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNA3 PLXNA1

2.19e-0391492IPR013548
DomainPlexin

PLXNA3 PLXNA1

2.19e-0391492IPR031148
Domain-

PLXNA3 SDK2 COL12A1 FN1 CD244 IL20RA NCAM2 NOMO1 ANOS1 CSF3R NOMO2 PLXNA1 NOMO3

2.55e-03663149132.60.40.10
DomainA2M

A2M PZP

2.73e-03101492PF00207
DomainA2M_N_2

A2M PZP

2.73e-03101492IPR011625
DomainA2M_comp

A2M PZP

2.73e-03101492IPR011626
DomainA2M_recep

A2M PZP

2.73e-03101492PF07677
DomainA2M_comp

A2M PZP

2.73e-03101492PF07678
Domain-

POR NOS3

2.73e-031014923.40.50.360
DomainA2M_N

A2M PZP

2.73e-03101492PF01835
DomainA2M_N

A2M PZP

2.73e-03101492IPR002890
DomainA-macroglobulin_rcpt-bd

A2M PZP

2.73e-03101492IPR009048
DomainALPHA_2_MACROGLOBULIN

A2M PZP

2.73e-03101492PS00477
DomainFlavoprotein-like_dom

POR NOS3

2.73e-03101492IPR029039
DomainFlavoprot_Pyr_Nucl_cyt_Rdtase

POR NOS3

2.73e-03101492IPR001709
DomainA2M_N_2

A2M PZP

2.73e-03101492PF07703
DomainMacroglobln_a2

A2M PZP

2.73e-03101492IPR001599
DomainP-loop_NTPase

MYH3 DNAH3 MYO7A ZGRF1 MCM4 MYO1B DHX33 AK3 DRG1 CDC42 HYDIN RAC1 MPP7 RAC2 RAC3

3.23e-0384814915IPR027417
DomainMyosin_head_motor_dom

MYH3 MYO7A MYO1B

3.42e-03381493IPR001609
DomainMYOSIN_MOTOR

MYH3 MYO7A MYO1B

3.42e-03381493PS51456
DomainMyosin_head

MYH3 MYO7A MYO1B

3.42e-03381493PF00063
DomainMYSc

MYH3 MYO7A MYO1B

3.42e-03381493SM00242
DomainFN3

SDK2 COL12A1 FN1 NCAM2 ANOS1 CSF3R

3.72e-031851496SM00060
DomainOxRdtase_FAD/NAD-bd

POR NOS3

3.96e-03121492IPR001433
DomainCarbonic_anhydrase_a-class_CS

CA7 CA8

3.96e-03121492IPR018338
DomainNAD_binding_1

POR NOS3

3.96e-03121492PF00175
DomainIg-like_fold

PLXNA3 SDK2 COL12A1 FN1 CD244 IL20RA NCAM2 NOMO1 ANOS1 CSF3R NOMO2 PLXNA1 NOMO3

4.33e-0370614913IPR013783
DomainTIL_dom

TECTA LRP2

5.40e-03141492IPR002919
DomainPI3/4_kinase_CS

PIK3C3 MTOR

6.20e-03151492IPR018936
DomainCarbonic_anhydrase_a-class

CA7 CA8

6.20e-03151492IPR023561
DomainALPHA_CA_1

CA7 CA8

6.20e-03151492PS00162
Domain-

DNAH3 MYO7A ZGRF1 MCM4 DHX33 AK3 DRG1 CDC42 HYDIN RAC1 MPP7 RAC2 RAC3

6.81e-03746149133.40.50.300
Domain-

PIK3C3 MTOR

7.05e-031614921.10.1070.11
DomainLaminin_N

LAMB4 LAMA2

7.05e-03161492IPR008211
DomainPI3Kc

PIK3C3 MTOR

7.05e-03161492SM00146
DomainLamNT

LAMB4 LAMA2

7.05e-03161492SM00136
DomainLAMININ_NTER

LAMB4 LAMA2

7.05e-03161492PS51117
DomainLaminin_N

LAMB4 LAMA2

7.05e-03161492PF00055
DomainCarb_anhydrase

CA7 CA8

7.95e-03171492PF00194
DomainCarb_anhydrase

CA7 CA8

7.95e-03171492SM01057
Domain-

CA7 CA8

7.95e-031714923.10.200.10
DomainALPHA_CA_2

CA7 CA8

7.95e-03171492PS51144
DomainCarbonic_anhydrase_a

CA7 CA8

7.95e-03171492IPR001148
PathwayWP_RALA_DOWNSTREAM_REGULATED_GENES

CDC42 RAC1 RAC2 RAC3

1.84e-06121134M39408
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_GH_TO_ITGA_B_RHOA_SIGNALING_PATHWAY

RAC1 RAC2 RAC3

1.71e-0571133M47538
PathwayWP_COMPREHENSIVE_IL17A_SIGNALING

FN1 MCM4 STAT3 PIK3C3 MTOR CDC42 RAC1

2.84e-051101137MM16642
PathwayWP_LEPTIN_SIGNALING

STAT3 MTOR PRKAA1 CDC42 NOS3 RAC1

3.22e-05761136M39491
PathwayWP_EGFEGFR_SIGNALING

SH3GL3 STAT3 GAB2 MTOR CDC42 NOS3 RAC1 PLCE1

4.71e-051621138M39334
PathwayKEGG_MEDICUS_REFERENCE_IGG_FCGR_RAC_SIGNALING_PATHWAY

RAC1 RAC2 RAC3

5.78e-05101133M47727
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_RHOG_RAC_SIGNALING_PATHWAY

FN1 RAC1 RAC2 RAC3

6.91e-05281134M47655
PathwayWP_INTERFERON_TYPE_I_SIGNALING

STAT2 STAT3 GAB2 MTOR RAC1

7.00e-05541135M39435
PathwayWP_PANCREATIC_ADENOCARCINOMA_PATHWAY

STAT3 MTOR CDC42 RAC1 RAC2 RAC3

7.86e-05891136M39732
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_FAK_RAC_SIGNALING_PATHWAY

FN1 RAC1 RAC2 RAC3

9.13e-05301134M47718
PathwayWP_RAS_SIGNALING

HTR7 GAB2 PLA2G4F CDC42 RAC1 RAC2 RAC3 PLCE1

1.15e-041841138M39764
PathwayREACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

PLXNA3 PLXNA1 RAC1

1.71e-04141133MM15029
PathwayREACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION

PLXNA3 PLXNA1 RAC1

1.71e-04141133M7578
PathwayWP_TARGET_OF_RAPAMYCIN_SIGNALING

MTOR PRKAA1 CDC42 RAC1

1.89e-04361134M39635
PathwayKEGG_PANCREATIC_CANCER

STAT3 CDC42 RAC1 RAC2 RAC3

2.42e-04701135M9726
PathwayKEGG_VIRAL_MYOCARDITIS

MYH3 LAMA2 RAC1 RAC2 RAC3

2.42e-04701135M12294
PathwayREACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

PLXNA3 PLXNA1 RAC1

2.60e-04161133M16498
PathwayKEGG_PATHWAYS_IN_CANCER

LAMB4 FN1 LAMA2 STAT3 CSF3R MTOR CDC42 RAC1 RAC2 RAC3

2.81e-0432511310M12868
PathwayWP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY

PIK3C3 RAC1 RAC2 RAC3

2.86e-04401134M39695
PathwayKEGG_VEGF_SIGNALING_PATHWAY

CDC42 NOS3 RAC1 RAC2 RAC3

3.56e-04761135M1749
PathwayWP_2Q211_COPY_NUMBER_VARIATION_SYNDROME

STAT3 CDC27 RAC1

3.75e-04181133M45539
PathwayPID_ERBB2_ERBB3_PATHWAY

STAT3 MTOR CDC42 RAC1

4.15e-04441134M175
PathwayREACTOME_SIGNALING_BY_MET

FN1 SH3GL3 LAMA2 STAT3 RAC1

4.26e-04791135M27643
PathwayWP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY

PIK3C3 RAC1 RAC2 RAC3

4.93e-04461134MM15837
PathwayREACTOME_INTERLEUKIN_20_FAMILY_SIGNALING

IL20RA STAT2 STAT3

5.18e-04201133MM15496
PathwayPID_IL6_7_PATHWAY

A2M STAT3 GAB2 RAC1

5.35e-04471134M183
PathwayKEGG_AXON_GUIDANCE

PLXNA3 CDC42 PLXNA1 RAC1 RAC2 RAC3

5.94e-041291136M5539
PathwayBIOCARTA_SALMONELLA_PATHWAY

CDC42 RAC1

6.27e-0451132M16120
PathwayWP_VEGFAVEGFR2_SIGNALING

FN1 MAPKAPK5 ARHGEF15 STAT3 MTOR PRKAA1 MMP10 CDC42 NOS3 RAC1 FBXW11

6.79e-0443111311M39729
PathwayREACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES

PIK3C3 RAC1 RAC2

8.98e-04241133M27553
PathwayWP_RANKLRANK_SIGNALING

GAB2 MTOR CDC42 RAC1

9.74e-04551134M39667
PathwayREACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES

PIK3C3 RAC1 RAC2

1.01e-03251133MM15269
PathwayREACTOME_METABOLISM_OF_COFACTORS

ACO1 STARD7 NOS3

1.01e-03251133M27855
PathwayREACTOME_METABOLISM_OF_COFACTORS

ACO1 STARD7 NOS3

1.01e-03251133MM15574
PathwayKEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS

GAB2 PLA2G4F CDC42 RAC1 RAC2

1.04e-03961135M16121
PathwayKEGG_FOCAL_ADHESION

LAMB4 FN1 LAMA2 CDC42 RAC1 RAC2 RAC3

1.10e-031991137M7253
PathwayWP_HIPPO_SIGNALING_REGULATION

MTOR PRKAA1 CDC42 CDH10 RAC1

1.14e-03981135M39830
PathwayREACTOME_INTERLEUKIN_20_FAMILY_SIGNALING

IL20RA STAT2 STAT3

1.14e-03261133M27750
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNB_G_RAC_SIGNALING_PATHWAY

RAC1 RAC2 RAC3

1.14e-03261133M47561
PathwayKEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNB_G_RAC_SIGNALING_PATHWAY

RAC1 RAC2 RAC3

1.14e-03261133M47562
PathwayWP_IL3_SIGNALING_PATHWAY

STAT3 GAB2 CDC42 RAC1 RAC2

1.24e-031001135MM15879
PathwayPID_CXCR4_PATHWAY

STAT2 STAT3 MTOR CDC42 RAC1

1.24e-031001135M124
PathwayREACTOME_VEGFR2_MEDIATED_VASCULAR_PERMEABILITY

MTOR NOS3 RAC1

1.27e-03271133M27422
PathwayWP_REGULATION_OF_ACTIN_CYTOSKELETON

FN1 PIK3C3 CDC42 RAC1 RAC2 RAC3

1.30e-031501136M39520
PathwayWP_REGULATION_OF_ACTIN_CYTOSKELETON

FN1 PIK3C3 CDC42 RAC1 RAC2 RAC3

1.39e-031521136MM15834
PathwayWP_IL19_SIGNALING

IL20RA STAT3 RAC1

1.42e-03281133M48111
PathwayPID_TRKR_PATHWAY

STAT3 GAB2 CDC42 RAC1

1.44e-03611134M187
Pubmed

rac, a novel ras-related family of proteins that are botulinum toxin substrates.

RAC1 RAC2 RAC3

8.51e-08315432674130
Pubmed

Activation of Rac-1, Rac-2, and Cdc42 by hemopoietic growth factors or cross-linking of the B-lymphocyte receptor for antigen.

CDC42 RAC1 RAC2

8.51e-083154312384416
Pubmed

Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size.

MTOR RAC1 RAC2

8.51e-083154321474067
Pubmed

Isoform-specific membrane targeting mechanism of Rac during Fc gamma R-mediated phagocytosis: positive charge-dependent and independent targeting mechanism of Rac to the phagosome.

RAC1 RAC2 RAC3

8.51e-083154316081809
Pubmed

Signaling and cytoskeletal requirements in erythroblast enucleation.

RAC1 RAC2 RAC3

8.51e-083154322461493
Pubmed

Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.

NOMO1 NOMO2 NOMO3

8.51e-083154336011023
Pubmed

Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development.

RAC1 RAC2 RAC3

8.51e-083154322123845
Pubmed

Rho family GTPases, Rac and Cdc42, control the localization of neonatal dentate granule cells during brain development.

CDC42 RAC1 RAC3

8.51e-083154330387892
Pubmed

Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.

NOMO1 NOMO2 NOMO3

8.51e-083154325576386
Pubmed

Pathophysiological Mechanisms in Neurodevelopmental Disorders Caused by Rac GTPases Dysregulation: What's behind Neuro-RACopathies.

RAC1 RAC2 RAC3

8.51e-083154334943902
Pubmed

The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation.

CDC42 RAC1 RAC2 RAC3

1.19e-0711154418786395
Pubmed

Plexin signaling via off-track and rho family GTPases.

PLXNA3 PLXNA1 RAC1 RAC2

2.56e-0713154411604131
Pubmed

The role of miR-451 in the switching between proliferation and migration in malignant glioma cells: AMPK signaling, mTOR modulation and Rac1 activation required.

MTOR PRKAA1 RAC1

3.39e-074154328440461
Pubmed

Structure of the TPR domain of p67phox in complex with Rac.GTP.

CDC42 RAC1 RAC2

3.39e-074154311090627
Pubmed

Phagocyte NADPH oxidase p67-phox possesses a novel carboxylterminal binding site for the GTPases Rac2 and Cdc42.

CDC42 RAC1 RAC2

3.39e-07415439642115
Pubmed

Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.

NOMO1 NOMO2 NOMO3

3.39e-074154331833031
Pubmed

Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton.

MTOR CDC42 RAC1

3.39e-074154324006489
Pubmed

A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.

NOMO1 NOMO2 NOMO3

3.39e-07415439267806
Pubmed

Cadherin-cadherin engagement promotes cell survival via Rac1/Cdc42 and signal transducer and activator of transcription-3.

STAT3 CDC42 RAC1

3.39e-074154319671682
Pubmed

Essential role of Rac1 and Rac3 GTPases in neuronal development.

CDC42 RAC1 RAC2 RAC3

3.57e-0714154419126596
Pubmed

Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.

MPO NOS3 RAC1 RAC2

4.86e-0715154419505917
Pubmed

DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA.

CDC42 RAC1 RAC2

8.46e-075154315023524
Pubmed

Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment.

CDC42 RAC1 RAC2

8.46e-075154316174757
Pubmed

PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase.

RAC1 RAC2 RAC3

8.46e-075154322043008
Pubmed

Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphoma.

MPO NOS3 RAC1 RAC2

1.08e-0618154419423521
Pubmed

Rho GTPases and the actin cytoskeleton.

CDC42 RAC1 RAC2

1.69e-06615439438836
Pubmed

Small GTP-binding proteins and the regulation of the actin cytoskeleton.

CDC42 RAC1 RAC2

1.69e-06615437888179
Pubmed

Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism.

ANOS1 CDC42 RAC1

1.69e-066154315548653
Pubmed

Regulation of cell protrusions by small GTPases during fusion of the neural folds.

PAX3 CDC42 RAC1

2.94e-067154327114066
Pubmed

Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity.

CDC42 RAC1 RAC2

2.94e-06715439490022
Pubmed

Polymorphisms in innate immunity genes and risk of childhood leukemia.

MPO CNTNAP1 DHX33 STAT2 STAT3 NOS3 RAC1 RAC2

4.12e-06206154820438785
Pubmed

Risk of meningioma and common variation in genes related to innate immunity.

MPO CNTNAP1 DHX33 STAT2 STAT3 NOS3 RAC1 RAC2

4.27e-06207154820406964
Pubmed

FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.

ACO1 IREB2 STAT3 MTOR

4.35e-0625154428069738
Pubmed

Common variation in genes related to innate immunity and risk of adult glioma.

MPO CNTNAP1 DHX33 STAT2 STAT3 NOS3 RAC1 RAC2

4.42e-06208154819423540
Pubmed

Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task.

RAC1 RAC2 RAC3

4.69e-068154324598074
Pubmed

ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration.

LRP2 CDC42 RAC1

4.69e-068154318426980
Pubmed

Generation and characterization of Rac3 knockout mice.

RAC1 RAC2 RAC3

4.69e-068154315964829
Pubmed

Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.

MYO7A CDH23 TECTA

4.69e-068154321165971
Pubmed

Vav GEFs are required for beta2 integrin-dependent functions of neutrophils.

CDC42 RAC1 RAC2

4.69e-068154315249579
Pubmed

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.

NOMO1 NOMO2 NOMO3

4.69e-068154315257293
Pubmed

CYBA encoding p22(phox), the cytochrome b558 alpha polypeptide: gene structure, expression, role and physiopathology.

RAC1 RAC2 RAC3

4.69e-068154327048830
Pubmed

Redundant functions of Rac GTPases in inner ear morphogenesis.

FN1 MYO7A RAC1 RAC3

5.12e-0626154422182523
Pubmed

PlexinA2 and semaphorin signaling during cardiac neural crest development.

PLXNA3 PAX3 PLXNA1

7.01e-069154311688557
Pubmed

Substrate-driven assembly of a translocon for multipass membrane proteins.

NOMO1 NOMO2 NOMO3

7.01e-069154336261522
Pubmed

Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development.

CDC42 RAC1 RAC2

9.99e-0610154334215617
Pubmed

Visualization of biochemical networks in living cells.

MTOR CDC42 RAC1

9.99e-0610154311438723
Pubmed

Regulation of lymphatic-blood vessel separation by endothelial Rac1.

RAC1 RAC2 RAC3

9.99e-0610154319906871
Pubmed

Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.

MYO7A CDH23 TECTA

1.37e-0511154331776257
Pubmed

An ER translocon for multi-pass membrane protein biogenesis.

NOMO1 NOMO2 NOMO3

1.37e-0511154332820719
Pubmed

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.

ZEB2 NOMO1 NOMO2 NOMO3

1.37e-0533154430783098
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

COL12A1 CNTNAP1 MYO1B STARD7 ANKHD1 BABAM2 STAT3 TSFM NDUFS8 DRG1 ERGIC1 CDC123 NOMO2 PIK3C3 CLPTM1 CDC27 CDC42 RAC1

1.89e-0512971541833545068
Pubmed

Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells.

CDC42 RAC1

1.95e-052154217356711
Pubmed

A regulated RNA binding protein also possesses aconitase activity.

ACO1 IREB2

1.95e-05215421946430
Pubmed

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.

ACO1 IREB2

1.95e-052154214726953
Pubmed

Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway.

MTOR PRKAA1

1.95e-052154232962728
Pubmed

Exenatide inhibits the growth of endometrial cancer Ishikawa xenografts in nude mice.

MTOR PRKAA1

1.95e-052154226648451
Pubmed

Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins.

ACO1 IREB2

1.95e-052154217200797
Pubmed

Role of crosstalk between STAT3 and mTOR signaling in driving sensitivity to chemotherapy in osteosarcoma cell lines.

STAT3 MTOR

1.95e-052154233448097
Pubmed

Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction.

CDC42 RAC1

1.95e-052154231825077
Pubmed

Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury.

CDC42 RAC1

1.95e-052154223677246
Pubmed

Lipid raft-associated GTPase signaling controls morphology and CD8+ T cell stimulatory capacity of human dendritic cells.

CDC42 RAC1

1.95e-052154215265891
Pubmed

In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation.

ACO1 IREB2

1.95e-052154219533074
Pubmed

Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2.

ACO1 IREB2

1.95e-052154215831703
Pubmed

Chlorination and oxidation of human plasma fibronectin by myeloperoxidase-derived oxidants, and its consequences for smooth muscle cell function.

MPO FN1

1.95e-052154230237127
Pubmed

Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins.

ACO1 IREB2

1.95e-052154225771171
Pubmed

Phosphoproteomic analysis reveals hyperactivation of mTOR/STAT3 and LCK/Calcineurin axes in pediatric early T-cell precursor ALL.

STAT3 MTOR

1.95e-052154228082737
Pubmed

Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements.

ACO1 IREB2

1.95e-05215428262972
Pubmed

A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.

CDC42 RAC1

1.95e-052154226071482
Pubmed

Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.

ACO1 IREB2

1.95e-052154216503547
Pubmed

Glycyrrhizic acid inhibits leukemia cell growth and migration via blocking AKT/mTOR/STAT3 signaling.

STAT3 MTOR

1.95e-052154226191214
Pubmed

Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases.

RAC1 RAC2

1.95e-052154214564009
Pubmed

Self-association and ligand-induced conformational changes of iron regulatory proteins 1 and 2.

ACO1 IREB2

1.95e-052154215938636
Pubmed

Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons.

RAC1 RAC3

1.95e-052154231369617
Pubmed

Alsin/Rac1 signaling controls survival and growth of spinal motoneurons.

ALS2 RAC1

1.95e-052154216802292
Pubmed

Knockdown of PLCε inhibits inflammatory cytokine release via STAT3 phosphorylation in human bladder cancer cells.

STAT3 PLCE1

1.95e-052154226156799
Pubmed

Rac regulates PtdInsP₃ signaling and the chemotactic compass through a redox-mediated feedback loop.

RAC1 RAC2

1.95e-052154221976675
Pubmed

Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.

CDC42 RAC1

1.95e-052154228450422
Pubmed

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia.

RAC1 RAC2

1.95e-052154221940819
Pubmed

Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.

ACO1 IREB2

1.95e-05215422172968
Pubmed

PDGF-induced human airway smooth muscle cell proliferation requires STAT3 and the small GTPase Rac1.

STAT3 RAC1

1.95e-052154218310224
Pubmed

Human neutrophils utilize a Rac/Cdc42-dependent MAPK pathway to direct intracellular granule mobilization toward ingested microbial pathogens.

CDC42 RAC1

1.95e-052154212511425
Pubmed

Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions.

RAC1 RAC2

1.95e-052154212391220
Pubmed

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation.

RC3H1 PRKAA1

1.95e-052154226496200
Pubmed

Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age-Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo.

RAC1 RAC2

1.95e-052154226496249
Pubmed

CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1.

CDC42 RAC1

1.95e-05215428994833
Pubmed

Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor.

ALS2 RAC1

1.95e-052154215033976
Pubmed

Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell and mTOR-STAT3 expression in liver cancer.

STAT3 MTOR

1.95e-052154225063062
Pubmed

Regulation of STAT3 by direct binding to the Rac1 GTPase.

STAT3 RAC1

1.95e-052154211021801
Pubmed

Rac1 and Rac3 GTPases regulate the development of hilar mossy cells by affecting the migration of their precursors to the hilus.

RAC1 RAC3

1.95e-052154221949760
Pubmed

Loss of Either Rac1 or Rac3 GTPase Differentially Affects the Behavior of Mutant Mice and the Development of Functional GABAergic Networks.

RAC1 RAC3

1.95e-052154226582364
Pubmed

The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes.

PIK3C3 MTOR

1.95e-052154221702994
Pubmed

Rac2 is required for the formation of neutrophil extracellular traps.

RAC1 RAC2

1.95e-052154221712395
Pubmed

Cross-talk between Rac1 and Cdc42 GTPases regulates formation of filopodia required for dengue virus type-2 entry into HMEC-1 cells.

CDC42 RAC1

1.95e-052154219710257
Pubmed

The atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics.

DOCK4 RAC1

1.95e-052154223720743
Pubmed

Involvement of the phosphatidylinositol 3-kinase/rac1 and cdc42 pathways in radial migration of cortical neurons.

CDC42 RAC1

1.95e-052154215557338
Pubmed

Serine-71 phosphorylation of Rac1/Cdc42 diminishes the pathogenic effect of Clostridium difficile toxin A.

CDC42 RAC1

1.95e-052154219709124
Pubmed

Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor.

CDC42 RAC1

1.95e-052154227355516
Pubmed

Adiponectin modulates the function of endothelial progenitor cells via AMPK/eNOS signaling pathway.

PRKAA1 NOS3

1.95e-052154228919424
Pubmed

Rac-Dependent Signaling from Keratinocytes Promotes Differentiation of Intradermal White Adipocytes.

RAC1 RAC3

1.95e-052154231351086
Pubmed

Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome.

RAC1 RAC2

1.95e-052154231221776
InteractionSUN2 interactions

RC3H1 SH3GL3 CTDNEP1 CDC123 PRKAA1 CDC42 RAC1 RAC2 RAC3 CDHR4 FBXW11

5.86e-0721315011int:SUN2
InteractionFLRT2 interactions

ADGRL1 CDC42 RAC1 RAC2 RAC3

2.20e-06291505int:FLRT2
InteractionFBXO2 interactions

PLXNA3 SDK2 COL12A1 FN1 CNTNAP1 NOMO1 CLPTM1 LRP2 TMEM131 TMEM231 PLXNA1 NOMO3 TCTN2 CDHR4

2.50e-0641115014int:FBXO2
InteractionMMP2 interactions

A2M COL12A1 FN1 RC3H1 STAT3 MMP10 PZP

3.91e-06871507int:MMP2
InteractionELMO2 interactions

DOCK4 DRG1 CDC27 RAC1 RAC2 FBXW11

4.52e-06581506int:ELMO2
InteractionCCDC47 interactions

MPO POR CTDNEP1 NOMO1 DRG1 ERGIC1 CDC123 CLPTM1 CDC42 NOMO3 RAC1 RAC2 RAC3 TCTN2

6.72e-0644815014int:CCDC47
InteractionATP1B3 interactions

CNTNAP1 NOMO1 COX5A CDC123 CDC42 RAC1 RAC2 DOP1A RAC3 TCTN2

9.30e-0623115010int:ATP1B3
InteractionNCLN interactions

NOMO1 DRG1 CDC123 NOMO2 CDC42 NOMO3 RAC1 RAC2 RAC3

9.53e-061831509int:NCLN
InteractionLAMTOR2 interactions

POR CDC123 MTOR PRKAA1 CDC27 CDC42 RAC2

1.74e-051091507int:LAMTOR2
InteractionDHRS7B interactions

BABAM2 CDC123 PRSS50 CDC42 RAC1 RAC2 TCTN2

1.74e-051091507int:DHRS7B
InteractionSTT3B interactions

POR DMXL1 ERGIC1 CDC123 CLPTM1 CDC42 RAC1 RAC2 RAC3 TCTN2

2.26e-0525615010int:STT3B
InteractionAMIGO2 interactions

CDC42 RAC1 RAC2 RAC3

2.79e-05241504int:AMIGO2
InteractionCLDN3 interactions

CDC42 RAC1 RAC2 RAC3

2.79e-05241504int:CLDN3
InteractionSCRIB interactions

FN1 P4HA3 ARHGEF15 SETD2 CDC123 PRKAA1 CDC42 RAC1 RAC2 RAC3

3.14e-0526615010int:SCRIB
InteractionLLGL1 interactions

DMXL1 ERGIC1 CDC123 CDC42 RAC1 RAC2 RAC3 FBXW11

3.20e-051641508int:LLGL1
InteractionLY86 interactions

PLXNA3 SDK2 DPCD CNTNAP1 NOMO1 TMEM131 PLXNA1 RAC3 TCTN2

3.68e-052171509int:LY86
InteractionPLXNA1 interactions

CDC123 CDC42 PLXNA1 RAC1 RAC2 RAC3 TCTN2

3.80e-051231507int:PLXNA1
InteractionZDHHC8 interactions

CDC42 RAC1 RAC2 RAC3

3.88e-05261504int:ZDHHC8
InteractionSLITRK4 interactions

CDC42 RAC1 RAC2 RAC3

3.88e-05261504int:SLITRK4
InteractionKIF26B interactions

CDC42 RAC1 MPP7 RAC2 RAC3

4.19e-05521505int:KIF26B
InteractionANO6 interactions

ERGIC1 CDC123 CDC27 CDC42 RAC1 RAC2 TCTN2

4.66e-051271507int:ANO6
InteractionGPAT4 interactions

ERGIC1 CDC123 CDC42 FEM1A RAC2 RAC3 TCTN2

5.15e-051291507int:GPAT4
InteractionTAFA4 interactions

FN1 CNTNAP1 LRP2 PLXNA1 TCTN2

5.51e-05551505int:TAFA4
InteractionOLR1 interactions

CDC42 RAC1 RAC2 RAC3

6.06e-05291504int:OLR1
InteractionARMCX3 interactions

POR PNKD NDUFS8 CDC123 PRKAA1 RAC2 RAC3

6.25e-051331507int:ARMCX3
InteractionARHGAP8 interactions

SH3GL3 CDC42 FEM1A RAC1

6.95e-05301504int:ARHGAP8
InteractionSLITRK5 interactions

CDC42 RAC1 RAC2 RAC3 TCTN2

7.74e-05591505int:SLITRK5
InteractionDCBLD1 interactions

CDC42 RAC1 RAC2 RAC3

7.93e-05311504int:DCBLD1
InteractionSLC16A7 interactions

CDC42 RAC1 RAC2 RAC3

9.01e-05321504int:SLC16A7
InteractionPLCB4 interactions

CDC42 RAC1 RAC2 RAC3

9.01e-05321504int:PLCB4
InteractionLYN interactions

SDK2 CDH23 ADGRL1 MYO1B DHX33 STAT3 GAB2 ERGIC1 CSF3R MICAL3 CDC42 PLXNA1 RAC1 MPP7 RAC2 RAC3

9.54e-0572015016int:LYN
InteractionTMCO1 interactions

CUX2 NOMO1 CDC123 CDC42 NOMO3 RAC1 KNL1 TCTN2

9.74e-051921508int:TMCO1
InteractionSLC2A1 interactions

STK17B ADARB1 TSFM ERGIC1 CDC123 CDC42 RAC1 RAC2 RAC3

9.99e-052471509int:SLC2A1
InteractionGLUD2 interactions

SH3GL3 CDC42 RAC2 RAC3

1.15e-04341504int:GLUD2
InteractionSLC6A15 interactions

NOMO1 ERGIC1 CDC123 CDC42 RAC1 RAC2 RAC3

1.17e-041471507int:SLC6A15
InteractionRPN1 interactions

FN1 RC3H1 POR ANKHD1 DMXL1 NOMO1 DRG1 ERGIC1 CDC123 NOMO2 CLPTM1 TMEM131 CDC42 RAC1 RAC2 RAC3 TCTN2

1.21e-0481415017int:RPN1
InteractionARHGEF40 interactions

CDC123 CDC42 RAC1 RAC2 RAC3

1.23e-04651505int:ARHGEF40
InteractionTMEM209 interactions

ERGIC1 CDC123 CDC42 RAC1 RAC2 RAC3 TCTN2

1.28e-041491507int:TMEM209
InteractionATP11A interactions

CDC42 RAC1 RAC2 RAC3

1.29e-04351504int:ATP11A
InteractionRASA3 interactions

CDC42 RAC1 RAC2 RAC3

1.29e-04351504int:RASA3
InteractionFLVCR1 interactions

ERGIC1 CDC123 CDC42 RAC1 RAC2 RAC3

1.35e-041051506int:FLVCR1
InteractionDIPK1B interactions

RBMS2 CDC123 TCTN2

1.39e-04141503int:DIPK1B
InteractionPCDH17 interactions

CDC42 RAC1 RAC2 RAC3

1.44e-04361504int:PCDH17
InteractionABL2 interactions

STAT3 CDC42 RAC1 RAC2 SCAI RAC3

1.50e-041071506int:ABL2
InteractionARHGEF7 interactions

CD244 MTOR CDC42 TRAPPC2L RAC1 RAC2 RAC3

1.51e-041531507int:ARHGEF7
InteractionSDF2L1 interactions

PLXNA3 HYAL1 CNTNAP1 CDC123 CLPTM1 TMEM131 PLXNA1 NOMO3 TCTN2 CDHR4

1.53e-0432215010int:SDF2L1
InteractionMUC13 interactions

CDC42 RAC1 RAC2 RAC3

1.61e-04371504int:MUC13
InteractionRRAS2 interactions

STAT3 CDC123 CDC42 RAC1 RAC2 RAC3

1.66e-041091506int:RRAS2
InteractionNDC1 interactions

CTDNEP1 ERGIC1 CDC123 CDC42 RAC1 RAC2 RAC3 TCTN2

1.69e-042081508int:NDC1
InteractionAKAP12 interactions

SH3GL3 CDC123 MTOR CDC42 RAC1 RAC2 RAC3

1.70e-041561507int:AKAP12
InteractionSLC11A2 interactions

CDC42 RAC1 RAC2 RAC3

1.79e-04381504int:SLC11A2
InteractionMTMR1 interactions

CDC42 FEM1A RAC1 RAC2 RAC3 FBXW11

1.83e-041111506int:MTMR1
InteractionSLC19A1 interactions

ERGIC1 CDC42 RAC1 RAC2 RAC3

1.87e-04711505int:SLC19A1
InteractionMELK interactions

RC3H1 CDH23 CDC123 CDC42 RAC1 RAC2

1.92e-041121506int:MELK
InteractionVPS13A interactions

SDK2 CTDNEP1 CDC42 RAC1 RAC2 RAC3

1.92e-041121506int:VPS13A
InteractionPI4K2A interactions

TMEM231 CDC42 NOS3 RAC1 RAC3

2.00e-04721505int:PI4K2A
InteractionDAAM1 interactions

CDC123 CDC42 RAC1 RAC2 RAC3

2.00e-04721505int:DAAM1
InteractionATP5MF-PTCD1 interactions

RC3H1 TSFM CDC123 CDC42 RAC1

2.00e-04721505int:ATP5MF-PTCD1
InteractionLEMD3 interactions

IREB2 CTDNEP1 ERGIC1 CDC123 CDC42 RAC1 RAC2 RAC3 TCTN2

2.01e-042711509int:LEMD3
InteractionSLC39A14 interactions

ERGIC1 CDC123 CDC42 RAC1 RAC2 RAC3

2.02e-041131506int:SLC39A14
InteractionVEZT interactions

MYO7A CTDNEP1 ERGIC1 CDC42 RAC2 RAC3 TCTN2

2.14e-041621507int:VEZT
InteractionIL6ST interactions

STAT3 CDC42 RAC1 RAC2 RAC3

2.28e-04741505int:IL6ST
InteractionPDF interactions

A2M P4HA3 STAT2 CDC123 RAC1

2.28e-04741505int:PDF
InteractionVAMP7 interactions

CDC123 TMEM231 CDC42 RAC1 RAC2 RAC3

2.33e-041161506int:VAMP7
InteractionAAAS interactions

CTDNEP1 CDC123 CDC42 RAC1 RAC2 RAC3 TCTN2

2.40e-041651507int:AAAS
InteractionSTAT1 interactions

DOCK4 POR MYO1B STAT2 STAT3 NOMO1 NOMO2 MTOR CDC42 RAC1

2.49e-0434215010int:STAT1
InteractionMPZL1 interactions

STAT3 CDC123 CDC42 RAC1 RAC2 RAC3

2.55e-041181506int:MPZL1
InteractionSLC30A1 interactions

IL20RA ERGIC1 CDC42 RAC1 RAC2 RAC3

2.55e-041181506int:SLC30A1
InteractionGARRE1 interactions

DOCK4 RC3H1 CDC42 RAC1 RAC2 RAC3 FBXW11

2.58e-041671507int:GARRE1
InteractionRELL1 interactions

CDC123 CDC42 RAC1 RAC2 RAC3

2.58e-04761505int:RELL1
InteractionPGRMC2 interactions

POR CTDNEP1 ERGIC1 CDC123 CDC42 RAC1 RAC2 RAC3 TCTN2

2.62e-042811509int:PGRMC2
InteractionPOR interactions

POR CTDNEP1 NDUFS8 CDC42 RAC1 RAC2 RAC3 TCTN2

2.63e-042221508int:POR
InteractionEPHA7 interactions

PLXNA3 MYO1B CDC123 TMEM231 PLXNA1 RAC1 MPP7 RAC2 RAC3

2.69e-042821509int:EPHA7
InteractionEXOSC10 interactions

RC3H1 ADARB1 NOMO1 DRG1 ANOS1 CDC123 NOMO2 NOMO3

2.71e-042231508int:EXOSC10
InteractionARHGDIB interactions

CDC42 RAC1 RAC2 RAC3

2.90e-04431504int:ARHGDIB
InteractionEMC3 interactions

CTDNEP1 CDC42 RAC1 RAC2 RAC3 TCTN2

2.93e-041211506int:EMC3
InteractionTHEM6 interactions

CDC123 TMEM231 CDC42 RAC1 RAC2 RAC3

2.93e-041211506int:THEM6
InteractionKRIT1 interactions

PIK3C3 RAC1 RAC2 RAC3

3.18e-04441504int:KRIT1
InteractionIL1RAP interactions

STAT3 CDC123 CCNI RAC1

3.18e-04441504int:IL1RAP
InteractionC2CD2 interactions

CDC42 RAC1 RAC2 RAC3

3.18e-04441504int:C2CD2
InteractionTRAF7 interactions

MAPKAPK5 MMP10 CDC42 RAC1 RAC2 FBXW11

3.20e-041231506int:TRAF7
InteractionCBARP interactions

CDC42 RAC1 RAC2 RAC3 FBXW11

3.28e-04801505int:CBARP
InteractionBRK1 interactions

SDK2 ANKHD1 CDC42 RAC1 RAC2 RAC3

3.34e-041241506int:BRK1
InteractionRFX6 interactions

ZMYND19 TENT5B PRKAA1 CDC42

3.47e-04451504int:RFX6
InteractionDIAPH3 interactions

PNKD CDC123 CDC42 RAC1 RAC2 RAC3

3.49e-041251506int:DIAPH3
InteractionCPB2 interactions

A2M FN1 PZP

3.59e-04191503int:CPB2
InteractionSPCS3 interactions

NOMO1 CDC123 CDC42 RAC1 RAC2 TCTN2

3.64e-041261506int:SPCS3
InteractionLSR interactions

MAPKAPK5 ERGIC1 TMEM231 CDC42 RAC1 RAC2 RAC3

3.67e-041771507int:LSR
InteractionCARMIL1 interactions

CDC123 CDC42 RAC1 RAC2 RAC3

3.68e-04821505int:CARMIL1
InteractionAUP1 interactions

ERGIC1 CDC123 CDC42 RAC1 RAC2 RAC3 TCTN2 FBXW11

3.75e-042341508int:AUP1
InteractionITGA1 interactions

CDC42 RAC1 RAC2 RAC3

3.77e-04461504int:ITGA1
InteractionITGA5 interactions

FN1 CDH23 CDC42 RAC1 RAC2 RAC3

3.79e-041271506int:ITGA5
InteractionMED12L interactions

MED6 MED1 SLITRK2 MED12L

4.10e-04471504int:MED12L
InteractionADIPOR1 interactions

TMEM231 RAC1 RAC3 TCTN2

4.10e-04471504int:ADIPOR1
InteractionPAK3 interactions

POR DRG1 CDC42 RAC1

4.10e-04471504int:PAK3
InteractionSLC38A1 interactions

ERGIC1 CDC123 CDC42 RAC1 RAC2 RAC3

4.12e-041291506int:SLC38A1
InteractionADGRL1 interactions

ADGRL1 CDC42 RAC1 RAC2 RAC3

4.34e-04851505int:ADGRL1
InteractionCDC42EP1 interactions

ERGIC1 CDC123 CDC42 RAC1 RAC2 RAC3

4.48e-041311506int:CDC42EP1
InteractionSLC38A2 interactions

ERGIC1 COX5A CDC42 RAC1 RAC2 RAC3

4.48e-041311506int:SLC38A2
InteractionADGRL2 interactions

CDC123 CDC42 RAC1 RAC2 RAC3

4.58e-04861505int:ADGRL2
GeneFamilyRho family GTPases

CDC42 RAC1 RAC2 RAC3

6.49e-06201134390
GeneFamilyFibronectin type III domain containing

SDK2 COL12A1 FN1 NCAM2 ANOS1 CSF3R

5.07e-041601136555
GeneFamilyCyclins|Mediator complex

MED6 MED1 MED12L

1.13e-033311331061
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

A2M PZP

1.35e-03911321234
GeneFamilyPlexins

PLXNA3 PLXNA1

1.35e-0391132683
GeneFamilyLaminin subunits

LAMB4 LAMA2

2.45e-03121132626
CoexpressionGU_PDEF_TARGETS_UP

DOCK4 FN1 PIK3C3 RAC2 RAC3 PLCE1

3.35e-06711506M3955
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 SPATA6L DCDC1 DENND2B CFAP57 TMEM231 PZP HYDIN CDHR4

2.53e-081931549ea345d34440b25f65358a53dc72831998d1c3620
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 DCDC1 CFAP57 TMEM231 PZP HYDIN TCTN2 CDHR4

2.75e-0718515485e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellControl-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

A2M DOCK4 SDK2 FN1 NCAM2 ADARB1 FRMD4B ADRA1A

3.79e-0719315485896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CUX2 COL12A1 LAMA2 MYO1B DENND2B ZEB2 ALX1

4.10e-071951548803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCellmoderate-Epithelial-Ciliated|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH3 SPATA6L DCDC1 CFAP57 TMEM231 HYDIN TCTN2 CDHR4

4.10e-071951548e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CUX2 COL12A1 LAMA2 MYO1B DENND2B ZEB2 ALX1

4.10e-0719515484f70157d42a16ff0259bc24a62803c4df4285c44
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

A2M DOCK4 SDK2 FN1 LAMA2 CDH23 NCAM2 FRMD4B

4.43e-071971548f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital|World / Primary Cells by Cluster

GPR22 TTC3 FRMD4B ZEB2 COX5A CDC42 CCNI RAC3

4.96e-0720015486bbe8e1f3e91678f1bfb14945365c1578a59a604
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital-19|World / Primary Cells by Cluster

GPR22 TTC3 FRMD4B ZEB2 COX5A CDC42 CCNI RAC3

4.96e-072001548c831d9e0a7178e3634da45548f91fa9e8dc6557c
ToppCellCiliated_cells-B-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

DNAH3 DCDC1 CFAP57 TMEM231 PZP HYDIN CDHR4

1.70e-0616415470e9961acbb1d6c0089e6805ba6756736fa4d8bed
ToppCellEntopeduncular-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

DNAH17 PRSS50 LRP2 HYDIN VWA5B1 CDHR4

1.77e-06105154676b73bc9236030e0703868fa8f7ecee2affe565b
ToppCellEntopeduncular-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

DNAH17 PRSS50 LRP2 HYDIN VWA5B1 CDHR4

1.77e-061051546bfd3395c51a0e868aa92eac4e929de59a3fe8b50
ToppCellEntopeduncular-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)--|Entopeduncular / BrainAtlas - Mouse McCarroll V32

DNAH17 PRSS50 LRP2 HYDIN VWA5B1 CDHR4

1.77e-06105154696566c83999aa625c84a4ed18a6df9daa99f9578
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

A2M CUX2 FN1 MCM4 NCAM2 ARSI TCHH

2.08e-06169154716c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 DCDC1 CFAP57 TMEM231 PZP HYDIN CDHR4

2.08e-06169154714aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 SPATA6L DCDC1 CFAP57 TMEM231 HYDIN CDHR4

2.43e-061731547c3762655caa79ac4879876f470d32578a3c93b01
ToppCellControl-Epithelial_cells-AT1|Control / group, cell type (main and fine annotations)

DOCK4 COL12A1 SH3GL3 MYO1B ANOS1 SCAI PLCE1

2.52e-061741547548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M COL12A1 GPR22 LAMA2 DENND2B ZEB2 ALX1

2.93e-06178154778a0c6340001a77f5b2d890b6263f574af2e72da
ToppCellCOVID-19-kidney-REN+Pericyte|kidney / Disease (COVID-19 only), tissue and cell type

A2M COL12A1 FN1 CNTNAP1 LAMA2 MYO1B ZEB2

3.04e-061791547342c1cc4444f51b8dcb30d3adc98285a25669c6e
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DCDC1 CNTNAP1 CFAP57 TMEM231 PZP HYDIN CDHR4

3.16e-06180154792fb01b91261b3103454924cde56add337b41844
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M COL12A1 NCAM2 SLITRK2 LRP2 HYDIN PLCE1

3.65e-0618415472cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M COL12A1 NCAM2 SLITRK2 LRP2 HYDIN PLCE1

3.65e-061841547ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M COL12A1 NCAM2 SLITRK2 LRP2 HYDIN PLCE1

3.65e-0618415472b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 SPATA6L DCDC1 CFAP57 TMEM231 HYDIN CDHR4

3.92e-06186154785787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

A2M DOCK4 FN1 LAMA2 NCAM2 ADARB1 ADRA1A

4.06e-06187154792d468dde81125d51daf7abd4703741abe1ab91c
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D175|Adult / Lineage, Cell type, age group and donor

A2M FN1 LAMA2 CDH23 NCAM2 ADARB1 ADRA1A

4.06e-061871547e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCellControl|World / Disease state, Lineage and Cell class

DOCK4 HIPK2 POR CDH23 ZEB2 GAB2 CSF3R

4.36e-061891547fb8dddd3b901081c6bb9ed6f32dafc5cce5f30be
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

A2M COL12A1 FN1 LAMA2 MYO1B DENND2B ADRA1A

4.67e-06191154704c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCellRA-09._Endothelium_I|RA / Chamber and Cluster_Paper

A2M DOCK4 RBMS2 CDH23 ARHGEF15 NOS3 CA8

4.83e-0619215478a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCellCOPD-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

A2M DOCK4 SDK2 FN1 NCAM2 ADARB1 FRMD4B

4.83e-06192154762904f94dfce430456f05066522cbf9bd29f4d7e
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

A2M DOCK4 FN1 LAMA2 NCAM2 ADARB1 ADRA1A

5.00e-06193154799525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

A2M DOCK4 SDK2 LAMA2 CDH23 NCAM2 ADARB1

5.00e-061931547b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 SPATA6L DCDC1 CFAP57 TMEM231 HYDIN CDHR4

5.17e-0619415471ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 SPATA6L DCDC1 CFAP57 TMEM231 HYDIN CDHR4

5.17e-0619415474a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M COL12A1 FN1 LAMA2 DENND2B ZEB2 ADRA1A

5.17e-061941547ebb038f94f49f5c655578d1b018676e10c6b7e3c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M COL12A1 LAMA2 MYO1B ZEB2 ALX1 CA8

5.35e-061951547d8ebb94f30d4a655d6b29dd6a3076be2403d2356
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH3 DCDC1 CFAP57 TMEM231 HYDIN TCTN2 CDHR4

5.35e-0619515473486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

A2M DOCK4 SDK2 FN1 NCAM2 ADARB1 FRMD4B

5.53e-0619615476730743cf088c419ccc2d28765769fc09d3ba6a7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M COL12A1 FN1 LAMA2 DENND2B ZEB2 ADRA1A

5.53e-061961547b8759e6231e0254797d6c30930407b79440c57bb
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

A2M DOCK4 SDK2 FN1 NCAM2 ADARB1 FRMD4B

5.53e-06196154721dab89f3699037138a9c7a0e4dc98739a9fad9c
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M FN1 LAMA2 NCAM2 ADARB1 ARSI ADRA1A

5.53e-0619615479737a5f006d37b549f281e1863aca558e1e4dc99
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M DOCK4 FN1 HYAL1 FRMD4B ARHGEF15 NOS3

5.53e-0619615478f2031b1a9232c389517fbf3c29f47f9468b0077
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M DOCK4 FN1 HYAL1 FRMD4B ARHGEF15 NOS3

5.53e-06196154748b4a9cea97a55190217deaf51bf867608c5a9a7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M DOCK4 FN1 HYAL1 FRMD4B ARHGEF15 NOS3

5.53e-061961547473980c827443464d08a0be28c53e3536369b12a
ToppCellNS-control-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 SPATA6L DCDC1 CFAP57 TMEM231 HYDIN CDHR4

5.53e-061961547d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M FN1 LAMA2 NCAM2 ADARB1 ARSI ADRA1A

5.53e-061961547cecf82cd5e0a3835d655f5e7478578674a63ce25
ToppCellPSB-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 DCDC1 DPCD CFAP57 TMEM231 HYDIN CDHR4

5.72e-0619715476865f4831eb23794fb88a8649d48d497bbae3f44
ToppCellNS-moderate-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 SPATA6L DCDC1 CFAP57 TMEM231 HYDIN CDHR4

5.72e-06197154771fea4aa6ce96c7693fa94792d08770622873850
ToppCellcontrol-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH3 SPATA6L DCDC1 CFAP57 TMEM231 HYDIN CDHR4

5.72e-061971547e453d085182364ca347cbcc9dc995c62c3353016
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CUX2 LAMA2 ZEB2 STAT2 ALX1 CA8

5.72e-061971547b349f8e96d61a4c296af64711e11fc44459a9413
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_PFC-23|World / Primary Cells by Cluster

SH3GL3 TTC3 FRMD4B ZEB2 COX5A CCNI RAC3

5.72e-061971547def63e7e28dd398722e528b7816a34de92552419
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_PFC|World / Primary Cells by Cluster

SH3GL3 TTC3 FRMD4B ZEB2 COX5A CCNI RAC3

5.72e-06197154726fd54acd90292a01ef0d892ba16ccdade987f36
ToppCellcontrol-Epithelial-Ciliated|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH3 SPATA6L DCDC1 CFAP57 TMEM231 HYDIN CDHR4

5.72e-061971547d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M FN1 LAMA2 NCAM2 ADARB1 ARSI ADRA1A

5.72e-06197154713896ec65ccda0b928c91d41112dc01b480036b7
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CUX2 LAMA2 ZEB2 STAT2 ALX1 CA8

5.72e-061971547c2e390653d5dee7e731c1840cfdab41987dede9b
ToppCellCOVID-19-lung-Fibroblast|COVID-19 / Disease (COVID-19 only), tissue and cell type

A2M FN1 LAMA2 CDH23 NCAM2 ADARB1 ADRA1A

5.91e-0619815473ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCellControl_saline-Epithelial_alveolar-AT_1|Control_saline / Treatment groups by lineage, cell group, cell type

POR MYO1B TENT5B ANOS1 PLXNA1 RAC3 PLCE1

5.91e-0619815479b161285df7a4e51618f3517cfc5b8221ba55786
ToppCellASK428-Epithelial-Type_1|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

DOCK4 COL12A1 MYO1B STARD7 TENT5B ANOS1 PLCE1

5.91e-0619815470047a9ef7684230ac5179efea94461480e90bdaf
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

A2M DOCK4 FN1 LAMA2 NCAM2 ADARB1 ADRA1A

6.31e-062001547e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DNAH3 DCDC1 CFAP57 TMEM231 PZP HYDIN CDHR4

6.31e-06200154785c98da55f7cd4ffdf9d309b56c8cc5d43f3c04c
ToppCellBiopsy_Control_(H.)-Epithelial-Differentiating_Ciliated|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

DNAH3 DPCD CFAP57 TMEM231 HYDIN CDHR4 PLCE1

6.31e-062001547a552a99f5e4fa00dfb7775e5a3e1f62f1530d104
ToppCellParenchymal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

A2M FN1 LAMA2 NCAM2 ADARB1 ZEB2 ADRA1A

6.31e-062001547cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DNAH3 DCDC1 CFAP57 TMEM231 PZP HYDIN CDHR4

6.31e-06200154712bc7d95c4166d12487081a76d210b7abe5991b0
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

A2M FN1 LAMA2 NCAM2 ADARB1 ZEB2 ADRA1A

6.31e-062001547311fab076f2ceb258e3970eb21e39344b894042a
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

A2M FN1 LAMA2 NCAM2 ADARB1 ZEB2 ADRA1A

6.31e-06200154734f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCellAdult-Mesenchymal-chondrocyte|Adult / Lineage, Cell type, age group and donor

A2M SDK2 FN1 LAMA2 ARSI SLITRK2

1.93e-0515915463f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|E18.5-samps / Age Group, Lineage, Cell class and subclass

DOCK4 FN1 ADARB1 ZEB2 MICAL3 PAX3

2.30e-051641546519ab4fe885dfe4c50846f346a062acc2cb44299
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CD244 HTR7 ZEB2 CSF3R DISP2 RAC2

2.73e-051691546c3d410a5e98000ba872141b62e17ef4ed3d1a8eb
ToppCellControl-Mast_cells|Control / group, cell type (main and fine annotations)

A2M GALC ALS2 ZEB2 MED12L PZP

2.73e-051691546fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 SPATA6L DCDC1 CFAP57 TMEM231 HYDIN

2.73e-051691546fba841664939c771881ba97f14ef1df6635c04ff
ToppCellControl-Mast_cells-Mast_cells|Control / group, cell type (main and fine annotations)

A2M GALC ALS2 ZEB2 MED12L PZP

2.82e-051701546c80f6d29096c372da95a8407f402349ff1bb7018
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL12A1 FN1 ZGRF1 LAMA2 DISP2 KNL1

2.91e-051711546b0373ed8283ee1792b6a490bff93906546978593
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL12A1 FN1 ZGRF1 LAMA2 DISP2 KNL1

2.91e-051711546b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P4HA3 ZEB2 TBC1D9 GAB2 DNAH17 TMEM231

3.42e-0517615465e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL12A1 HTR7 FRMD4B ADRA1A SLITRK2 PLCE1

3.65e-0517815466ad46b0720298bcb927fd53468bb4ea0c199ad35
ToppCellnormal_Pleural_Fluid-Myeloid_cells-mo-Mac|normal_Pleural_Fluid / Location, Cell class and cell subclass

A2M DOCK4 CUX2 FN1 ANOS1 MMP10

3.76e-051791546cd3c58e044f5a38e815313a1636153d81a592fce
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SDK2 FN1 ADARB1 ZEB2 CPXM1 MICAL3

3.76e-051791546b559f5a72cc9e3e35d05cb539b5c2e006e56e652
ToppCellcritical-Lymphoid-NK|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

A2M NCAM2 ARHGEF15 SLITRK2 ALX1 PAX3

3.88e-0518015465abf778395392244daaec876f306ed7e4f388686
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DNAH3 DCDC1 CFAP57 TMEM231 HYDIN CDHR4

4.00e-051811546dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

DNAH3 DCDC1 CFAP57 TMEM231 HYDIN CDHR4

4.13e-051821546fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M COL12A1 LAMA2 P4HA3 ZEB2 CPXM1

4.13e-051821546b7d532feb73167e05475855061b35a209583f44c
ToppCellNS-critical-d_07-13-Lymphoid-NK|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

A2M NCAM2 ARHGEF15 SLITRK2 ALX1 PAX3

4.13e-051821546dd1c59babf7211362452e3e264009d70004d99f6
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M COL12A1 LAMA2 P4HA3 ZEB2 CPXM1

4.13e-051821546af65f0fc3f9e5d9ce69ee5faaf5b6cb7f8412e0c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

COL12A1 FN1 LAMA2 DENND2B ZEB2 PLCE1

4.25e-051831546667717366cb181b8a04a347e64f0f5a4dfc6ee7f
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HTR7 FRMD4B ANOS1 ADRA1A SLITRK2 PLCE1

4.39e-0518415462ba98708dfd7f1b2a661578a334684094ff453ad
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL12A1 SH3GL3 MYO1B ANOS1 SCAI PLCE1

4.39e-05184154657c792e6e2fedba25d3350ffe649fd74750b579d
ToppCellIPF-Myeloid-Mast|World / Disease state, Lineage and Cell class

A2M GALC ALS2 TSEN54 PZP RAC2

4.39e-0518415467aefa182acad5a53c730945fec85329d7168606a
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D122|Adult / Lineage, Cell type, age group and donor

COL12A1 SH3GL3 MYO1B ANOS1 SCAI PLCE1

4.39e-051841546561592edc3083fad41b91811151b442207c65dd9
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL12A1 SH3GL3 MYO1B ANOS1 SCAI PLCE1

4.39e-051841546d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DNAH3 DCDC1 CFAP57 TMEM231 HYDIN CDHR4

4.39e-0518415465daff849625f2f41d56615569c0ed59cd733b34c
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL12A1 SH3GL3 MYO1B ANOS1 SCAI PLCE1

4.52e-0518515461c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCellCiliated_cells-B-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

DNAH3 DCDC1 CFAP57 TMEM231 HYDIN CDHR4

4.52e-0518515464fc7113d3dadc716ec5a8e62b58543cc00ce5b16
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

DNAH3 DCDC1 CFAP57 TMEM231 HYDIN CDHR4

4.52e-05185154630f4980dee6cd5959655f8d74049f3bfb5312611
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

DNAH3 DCDC1 CFAP57 TMEM231 HYDIN CDHR4

4.52e-05185154618a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FN1 HIPK2 CDH23 NCAM2 ADARB1 ZEB2

4.52e-0518515461ac6a32cc56d5d819649bdd99518e2ead0eead4c
ToppCellCiliated_cells-B-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

DNAH3 DCDC1 CFAP57 TMEM231 HYDIN CDHR4

4.66e-051861546f72267d533fd0c5280d9741ceee3dd116300a7e4
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 DCDC1 CFAP57 TMEM231 HYDIN CDHR4

4.66e-05186154676033438426d8f9c72cd6691a7baf92104c9f03d
ToppCellEpithelial-alveolar_epithelial_cell_type_1|World / Lineage, Cell type, age group and donor

COL12A1 SH3GL3 MYO1B ANOS1 SCAI PLCE1

4.66e-05186154609d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCellControl-Endothelial-Endothelial-Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK4 HYAL1 HIPK2 CTIF DENND2B ARHGEF15

4.80e-051871546ea9d34bcd3bd1f36745846309ede349773de501a
ToppCellCiliated_cells-B-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

DCDC1 CFAP57 TMEM231 PZP HYDIN CDHR4

4.80e-0518715462b4262c2e7c7830a976be168cee6eeb738d4feda
DrugFe(III

MPO ACO1 POR IREB2 P4HA3 PNKD NDUFS8 SETD2 COX5A MTOR VPS41 MMP10 NOS3 RAC2 PLCE1

2.80e-0653715015CID000023925
DrugNSC 23766

MPO CDC42 RAC1 RAC2

5.15e-06181504ctd:C487513
DrugB258

RAC1 RAC2 RAC3

5.52e-0661503CID000593690
Drugpyridine hemochrome

MPO CD244 POR PNKD RAC2

8.11e-06421505CID000188327
Drugblebbistatin

MYH3 FN1 MYO7A MYO1B MTOR CDC42 RAC1

1.20e-051161507CID003476986
Drug4-epidoxorubicin

MYH3 ACO1 HIPK2 POR IREB2 STAT2 STAT3 TBC1D9 COX5A NOMO2 PIK3C3 MTOR CLPTM1 NOS3 PLXNA1 KNL1 CA8

1.81e-0578815017CID000001690
DrugMn(III)TMPyP

ACO1 IREB2 NOS3

2.29e-0591503CID005486195
DrugSimvastatin

MPO A2M COL12A1 FN1 MCM4 STAT3 MTOR PRKAA1 MMP10 CDC42 NOS3 RAC1 RAC2 RAC3

3.16e-0558115014ctd:D019821
Drug3 PL

CD244 RAC1 RAC2

3.25e-05101503CID000007707
Drugperoxynitrite

MPO FN1 ACO1 POR IREB2 ALS2 NDUFS8 ADRA1A COX5A MMP10 NOS3

3.85e-0537315011CID000104806
DrugAC1L9J09

ACO1 POR IREB2 TSFM PIK3C3

4.02e-05581505CID000446034
Drugnitrotyrosine

MPO ACO1 IREB2 NDUFS8 NOS3 RAC1

4.21e-05961506CID000065124
Drugh 166

MPO FN1

4.31e-0521502CID003057962
Drugp-nitrophenylhydroxylamine

ACO1 IREB2

4.31e-0521502CID005486551
DrugTetrandrine [518-34-3]; Down 200; 6.4uM; HL60; HT_HG-U133A

DNAH3 FN1 ADGRL1 CTIF BABAM2 STAT2 CDH10 PLXNA1

4.51e-0519415082520_DN
DrugNSC23766

MPO SETD2 CDC42 RAC1 RAC2 RAC3

4.73e-05981506CID000409805
DrugMinaprine dihydrochloride [25953-17-7]; Up 200; 10.8uM; HL60; HG-U133A

MED6 FN1 ORAI2 ADARB1 TSFM NDUFS8 SETD2 CLCN6

4.85e-0519615081968_UP
DrugColistin sulfate [1264-72-8]; Up 200; 3uM; HL60; HT_HG-U133A

CUX2 GPR22 FN1 CNTNAP1 ADARB1 VPS41 CDC42 DOP1A

4.85e-0519615082491_UP
DrugEDHB

FN1 ACO1 P4HA3 SETD2

4.96e-05311504CID000077547
DrugAmrinone [60719-84-8]; Up 200; 21.4uM; PC3; HT_HG-U133A

LAMB4 HIPK2 LAMA2 IL20RA ADARB1 ADRA1A DNAH17 LRP2

5.02e-0519715084488_UP
DrugMevalonic-D, L acid lactone [674-26-0]; Down 200; 30.8uM; PC3; HT_HG-U133A

FN1 IREB2 TSFM GAB2 LRP2 TMEM231 RAC3 CA8

5.21e-0519815085738_DN
Drugferric citrate

ACO1 POR IREB2 PNKD NOMO1

5.55e-05621505CID000031083
DrugAC1MMOKY

MPO GALC NOS3

5.90e-05121503CID003289210
Diseaseautosomal dominant intellectual developmental disorder 48 (implicated_via_orthology)

RAC1 RAC2 RAC3

1.21e-0731473DOID:0080235 (implicated_via_orthology)
DiseaseMalignant neoplasm of breast

FN1 LAMA2 CTIF TECTA TTC3 ZEB2 STAT3 CRYAA SETD2 ADRA1A MTOR PRKAA1 MMP10 CDC27 NOS3 CDH10 RAC2 DOP1A

7.09e-06107414718C0006142
DiseaseIntellectual Disability

CUX2 TSEN54 SETD2 MTOR MED12L LRP2 CDC42 RAC1 RAC3 FBXW11 CA8

1.59e-0544714711C3714756
Diseasekidney disease (implicated_via_orthology)

CDC42 RAC1 RAC2 RAC3

5.19e-05411474DOID:557 (implicated_via_orthology)
Diseasemyeloid white cell count

MPO FN1 RC3H1 CDH23 MYO1B CTIF PNKD DENND2B AK3 DRG1 SETD2 OR10J5 CSF3R MED12L PLCE1

7.23e-0593714715EFO_0007988
Diseaseduodenal ulcer (implicated_via_orthology)

ACO1 STAT3

7.37e-0531472DOID:1724 (implicated_via_orthology)
DiseaseAlzheimer disease type 1

MPO NOS3

1.47e-0441472cv:C1863052
DiseaseALZHEIMER DISEASE, FAMILIAL, 1

MPO NOS3

1.47e-0441472104300
Diseasevasculitis (is_implicated_in)

MPO NOS3

1.47e-0441472DOID:865 (is_implicated_in)
DiseaseUreteral obstruction

FN1 HIPK2 NOS3

2.27e-04241473C0041956
DiseaseUsher syndrome, type 1A

MYO7A CDH23

2.44e-0451472C2931205
Diseaseporphyria (implicated_via_orthology)

ACO1 IREB2

2.44e-0451472DOID:13268 (implicated_via_orthology)
DiseaseUSHER SYNDROME, TYPE IB (disorder)

MYO7A CDH23

2.44e-0451472C1848638
DiseaseUSHER SYNDROME, TYPE IA, FORMERLY

MYO7A CDH23

2.44e-0451472C1848639
DiseaseUSHER SYNDROME, TYPE I, FRENCH VARIETY, FORMERLY

MYO7A CDH23

2.44e-0451472C1848640
DiseaseUsher syndrome type 1

MYO7A CDH23

2.44e-0451472cv:C1568247
DiseaseUsher Syndrome, Type I

MYO7A CDH23

3.65e-0461472C1568247
Diseasemyocardial infarction

CUX2 FN1 DENND2B ZEB2 STAT3 COX5A CDC123 NOS3

3.86e-043501478EFO_0000612
DiseaseHereditary retinal dystrophy

MYO7A CDH23

5.09e-0471472C0154860
DiseaseUsher syndrome

MYO7A CDH23

5.09e-0471472cv:C0271097
Diseaseneutropenia (implicated_via_orthology)

STAT3 CSF3R

5.09e-0471472DOID:1227 (implicated_via_orthology)
DiseaseEarly-onset autosomal dominant Alzheimer disease

MPO NOS3

5.09e-0471472cv:CN043596
DiseaseAlzheimer's disease (is_implicated_in)

A2M IREB2 STAT3 ADRA1A NOS3

5.34e-041321475DOID:10652 (is_implicated_in)
Diseasecoffee consumption

LAMB4 CUX2 POR

5.40e-04321473EFO_0004330
DiseaseNeoplastic Cell Transformation

FN1 POR ZEB2 STAT3 RAC1

6.75e-041391475C0007621
DiseaseAlzheimer disease

MPO NOS3

6.77e-0481472cv:C0002395
Diseaseobesity (implicated_via_orthology)

SDK2 DHX33 ADARB1 STAT3 PRKAA1 MED12L

7.52e-042151476DOID:9970 (implicated_via_orthology)
Diseasechronic lymphocytic leukemia (is_marker_for)

STAT3 AK3

8.67e-0491472DOID:1040 (is_marker_for)
DiseaseBMI-adjusted waist circumference, forced expiratory volume

CUX2 MAPKAPK5

8.67e-0491472EFO_0004314, EFO_0007789
Diseasevital capacity

NBPF12 FN1 LAMA2 TSEN54 CTIF MED1 ALX1 CDC123 LRP2 DISP2 MICAL3 PLXNA1 VWA5B1 RAC3 PLCE1

1.33e-03123614715EFO_0004312
Diseaselymphangioleiomyomatosis (is_marker_for)

STAT3 NOS3

1.57e-03121472DOID:3319 (is_marker_for)
DiseaseAcute kidney injury

MPO A2M LRP2 NOS3

1.66e-031011474C2609414
DiseaseAcute Kidney Insufficiency

MPO A2M LRP2 NOS3

1.66e-031011474C1565662
DiseaseKidney Failure, Acute

MPO A2M LRP2 NOS3

1.66e-031011474C0022660
Diseaseblood phosphate measurement

CUX2 DCDC1 OR10J5 TMEM131 KNL1

1.83e-031741475EFO_0010972
Diseaseiron deficiency anemia (biomarker_via_orthology)

FN1 IREB2

1.85e-03131472DOID:11758 (biomarker_via_orthology)
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

MYO7A CDH23 TECTA

2.12e-03511473cv:CN043650
Diseasemembranous glomerulonephritis (biomarker_via_orthology)

A2M LRP2

2.16e-03141472DOID:10976 (biomarker_via_orthology)
DiseaseCiliopathies

MYO7A CDH23 TMEM231 TCTN2

2.27e-031101474C4277690
DiseaseNeoplasm Invasiveness

FN1 ACO1 IREB2 ZEB2 GAB2

2.34e-031841475C0027626
DiseaseMeckel-Gruber syndrome

TMEM231 TCTN2

2.48e-03151472C0265215
Diseaseleukemia

STAT3 SETD2 CSF3R

2.63e-03551473C0023418
DiseaseCarcinoma, Granular Cell

STAT3 MTOR NOS3 PLCE1

2.75e-031161474C0205644
DiseaseAdenocarcinoma, Tubular

STAT3 MTOR NOS3 PLCE1

2.75e-031161474C0205645
DiseaseAdenocarcinoma, Oxyphilic

STAT3 MTOR NOS3 PLCE1

2.75e-031161474C0205642
DiseaseCarcinoma, Cribriform

STAT3 MTOR NOS3 PLCE1

2.75e-031161474C0205643
DiseaseAdenocarcinoma, Basal Cell

STAT3 MTOR NOS3 PLCE1

2.75e-031161474C0205641
DiseaseAdenocarcinoma

STAT3 MTOR NOS3 PLCE1

2.75e-031161474C0001418
Diseaseisoleucine measurement

LAMA2 DRG1 CFAP57

2.77e-03561473EFO_0009793
Diseasebasophil count

MPO CUX2 GALC MCM4 PNKD SETD2 CSF3R PLCE1

2.99e-034831478EFO_0005090
DiseaseFEV/FEC ratio

SOX30 SH3GL3 CDH23 IREB2 TSEN54 BABAM2 DENND2B ZEB2 GAB2 ERGIC1 CDC123 MICAL3 MPP7 CDHR4

3.38e-03122814714EFO_0004713
Diseasewhite matter microstructure measurement

SDK2 DCDC1 HTR7 OR2J3 ANKHD1 FRMD4B LRP2

3.50e-033901477EFO_0005674
DiseaseMeckel syndrome type 1

TMEM231 TCTN2

3.58e-03181472C3714506
Diseasemean arterial pressure

CUX2 DCDC1 HIPK2 MAPKAPK5 TENT5B CLCN6 NOS3 PLCE1

3.64e-034991478EFO_0006340
Diseaseneutrophil count

MPO CUX2 SPATA6L RC3H1 CDH23 MYO1B PNKD DENND2B TENT5B AK3 DRG1 SETD2 COX5A CSF3R HYDIN

3.85e-03138214715EFO_0004833
Diseasehypertension (implicated_via_orthology)

FN1 MTOR LRP2 NOS3

3.91e-031281474DOID:10763 (implicated_via_orthology)
Diseaseportal hypertension (implicated_via_orthology)

MTOR NOS3

3.99e-03191472DOID:10762 (implicated_via_orthology)
Diseaserenovascular hypertension (biomarker_via_orthology)

MPO LAMA2

3.99e-03191472DOID:1591 (biomarker_via_orthology)
Diseaseglomerulonephritis (is_marker_for)

MPO FN1

3.99e-03191472DOID:2921 (is_marker_for)
Diseasehydrocephalus (implicated_via_orthology)

DPCD HYDIN

3.99e-03191472DOID:10908 (implicated_via_orthology)
Diseasepolycystic kidney disease (biomarker_via_orthology)

MTOR NOS3

3.99e-03191472DOID:0080322 (biomarker_via_orthology)
Diseasetea consumption measurement

LAMA2 POR MAPKAPK5 FRMD4B

4.02e-031291474EFO_0010091
Diseasetransient cerebral ischemia (implicated_via_orthology)

ADARB1 STAT3 NOS3

4.04e-03641473DOID:224 (implicated_via_orthology)
Diseasemaximal midexpiratory flow rate

MED12L MICAL3

4.42e-03201472EFO_0004313
DiseaseFamilial aplasia of the vermis

TMEM231 TCTN2

4.42e-03201472cv:C0431399
Diseasehaptoglobin measurement

CMTR2 HYDIN

4.86e-03211472EFO_0004640

Protein segments in the cluster

PeptideGeneStartEntry
TRANYLASPPLVIAY

ACO1

546

P21399
TYDISVLPRTDSYPQ

ALX1

206

Q15699
LQTTSGPYLLIYPQL

C2orf16

1136

Q68DN1
TSPYVYQLTTRPVTD

CNTNAP1

1126

P78357
LTPPITQYYNRTIQK

CTIF

581

O43310
IPSYPDTQAVNEYLR

ALS2

336

Q96Q42
QAVHTPLQSPREYLY

ARSI

236

Q5FYB1
EIYYTSRPPALVARN

ADGRL1

1421

O94910
IGVSYPLRYPTIVTQ

ADRA1A

126

P35348
QSSLPLNSVYVYRPL

CCNI

251

Q14094
YQDLPNPVFRYLQSV

CMTR2

691

Q8IYT2
TYYTLPNATVAPETR

CPXM1

466

Q96SM3
YAYIQRIPVPNLVDS

DOP1A

1906

Q5JWR5
PLQDEPLYQTYRAAV

ARHGEF15

346

O94989
AYQLEPYPSQQTIEL

CUX2

1186

O14529
RNTYLPEVSYQFPKL

DENND2B

711

P78524
NRPIFSQPLYNISLY

CDH23

456

Q9H251
TKPRVIDLSQYSPTY

DMXL1

1466

Q9Y485
LSPQTTDYQVPSLKY

DISP2

421

A7MBM2
IPQEPQRLIYSYSIV

CDHR4

576

A6H8M9
YVLLAYLTAQPAPTS

A2M

1211

P01023
VPSYVPESRERYQQI

RC3H1

701

Q5TC82
SYVLLAYLTAQPAPT

PZP

1216

P20742
STLPRSQYDYILPQV

NOMO3

1116

P69849
PYLSSPVSSYQRVTQ

RBMS2

281

Q15434
QEDYDRLRPLSYPQT

RAC2

61

P15153
QEDYDRLRPLSYPQT

RAC3

61

P60763
QEDYDRLRPLSYPQT

RAC1

61

P63000
VRANYLASPPLVVAY

IREB2

621

P48200
LDVRPPYAEYLQVVN

P4HA3

416

Q7Z4N8
VQLETQYQYPRPLLI

ORAI2

81

Q96SN7
THLTYRIVNYTPDLP

MMP10

111

P09238
HYVLTVPNLRPSTLY

ANOS1

616

P23352
NLYRQLISYPQEVIP

MCM4

221

P33991
TVNPIYKYILNDLPR

DCDC1

41

M0R2J8
STLPRSQYDYILPQV

NOMO2

1116

Q5JPE7
PGQSPQLLIYTLSYR

IGKV2D-40

66

P01614
SQYSIDPVTRYPNIN

MICAL3

461

Q7RTP6
ANPEVSILNYPSTLY

HIPK2

606

Q9H2X6
QSNIYRVPPNYSPIS

MED12L

1786

Q86YW9
TPYYVAPQVLEAQRR

MAPKAPK5

186

Q8IW41
QLPDYTSPVVLPYSR

DRG1

301

Q9Y295
LTYYLDITNPPRTNV

POR

371

P16435
QYDYLDPRQITPSLE

MTO1

406

Q9Y2Z2
YLLAQTSPPESNLVY

CFAP57

121

Q96MR6
PYVYAFLQTKVPQRS

AK3

206

Q9UIJ7
SVPLYNTLLPYTFLE

FSIP2

4456

Q5CZC0
QPYLLDPSITLGQYV

TSFM

286

P43897
LLVLNSTSFLYYPDP

PLXNA1

1136

Q9UIW2
IYTYTQDPTVTRLEP

PLXNA3

1016

P51805
LPTYRSYNDSVDPRI

MPO

476

P05164
SPITVKYTERRQPLY

ERGIC1

236

Q969X5
PNSFYRSLYPKIIQD

FBXW11

201

Q9UKB1
VPTYEEVTPYRRQTN

MPP7

351

Q5T2T1
STLPRSQYDYILPQV

NOMO1

1116

Q15155
LAVLLQTSPEAPYIY

DPP3

46

Q9NY33
QTSPEAPYIYALLSR

DPP3

51

Q9NY33
LSPSQYINEENLPVY

KNL1

1731

Q8NG31
ISRTPYNILSSPDYV

LAMA2

2501

P24043
PINYTTRRIGPVTYS

LAMA2

2891

P24043
TETNPQVYYQASLRP

LRP2

631

P98164
QEDYDRLRPLSYPQT

CDC42

61

P60953
TYRVQYIQDIILPTP

PPP4R3B

266

Q5MIZ7
NPYPIYTSVNVRTNL

PLA2G4F

491

Q68DD2
YQRISNIEDLPPLYT

ADARB1

601

P78563
SSTPINTRIEPYYSI

GPR75

471

O95800
LQYSYTPQLQDLDPL

IL20RA

446

Q9UHF4
TLSYLFREPATINYP

NDUFS8

71

O00217
QLPLLQPRYYSVSSA

NOS3

931

P29474
TLPTYQLSETSYQPT

PAX3

301

P23760
VYNPLPSPSRQYTEI

FRMD4B

986

Q9Y2L6
EPNLTYVYPHTRIQS

CLCN6

606

P51797
IPITFYPRESINYQE

HYDIN

4376

Q4G0P3
YAYTRTVPITPDNVE

KLHL10

96

Q6JEL2
YTNPDSRYILLPVVL

DOCK4

821

Q8N1I0
EATQVYPKLYLSPRI

BABAM2

211

Q9NXR7
NSEVTVQPSPYLSYR

CDC123

291

O75794
PVQQYRIIYSPTVGD

COL12A1

2051

Q99715
YEYLGNTPRLVITPL

DNAH17

1811

Q9UFH2
YITTRLRNPHYLPEV

DNAH3

3171

Q8TD57
TYLLPVVISDNDYPI

CDH10

561

Q9Y6N8
YPLRNLQPASEYTVS

FN1

1051

P02751
TIYAITPTYSRPVQK

B3GAT2

81

Q9NPZ5
IRNLPYPKDVYSVSV

DPCD

106

Q9BVM2
YDPSLLDVRLSPNYV

CA8

61

P35219
PPQLVLAYDYSREVN

FEM1A

341

Q9BSK4
PLYASLPYAQQLRVF

DHX33

326

Q9H6R0
PFQLYEIIVTPLYQD

CSF3R

496

Q99062
LPQAPSRQISYPYSA

HOXC11

51

O43248
SRQISYPYSAQVPPV

HOXC11

56

O43248
NPYSPYIQDLVTLTN

LAMB4

211

A4D0S4
PGQSPQLLIYTLSYR

IGKV2-40

66

A0A087WW87
YPSNLVYSTEPLISQ

KRTAP23-1

31

A1A580
VYSPSLQPLELSYEA

CA7

41

P43166
LPVLPYVQIFYDTTN

HYAL1

281

Q12794
LLPFLSSTISPYYRQ

CRYAA

36

P02489
YQPLSYPLSFQVSLT

GPR22

31

Q99680
EIYPYVIQELRPTLN

COX5A

121

P20674
ATSRLLVNYPEPYRS

GALC

66

P54803
PVRYYTIQTRELPSG

SDK2

1431

Q58EX2
SYLQNYTNTPPVIDV

CDC27

296

P30260
APTSQEPAYTLYSLI

CD244

306

Q9BZW8
ETQPTYAPLYELITQ

MED1

331

Q15648
RQSPAQVIPLADYYI

MED6

86

O75586
YSVVTPLLNPVIYSL

OR11G2

316

Q8NGC1
YTVLSPTLNPLIYTL

OR13A1

296

Q8NGR1
TYTIITPLLNPVVYS

OR10J5

276

Q8NHC4
YTVVTPSLNPLIYTL

OR2J3

281

O76001
RYHPQALIYPLTVAS

MTOR

1966

P42345
QPTLSTSAPQEYLYL

GAB2

181

Q9UQC2
LYRELNSSPQPYLVP

TAF4

641

O00268
STSEVNYIIERPSYP

SPATA6L

366

Q8N4H0
ENYPLYIRSTPTENE

TRAPPC2L

11

Q9UL33
VLPIPVLSDNYSYLI

PNKD

121

Q8N490
YSVQPYTKEVLQSLP

STAT2

626

P52630
LSKTTEYLQPNPAYR

SH3GL3

51

Q99963
YVVRRFQPSSVLSPY

TSEN54

166

Q7Z6J9
YSTLSIPPERLASYQ

NBPF12

836

Q5TAG4
YSILSNPNPSDYVLL

PLCE1

2176

Q9P212
LNIIVSYPPTKQLTY

PIK3C3

296

Q8NEB9
FTTVSLLQPPQYRIY

SLITRK2

51

Q9H156
YLAPEILNYDPITTA

STK17B

201

O94768
LLLITTNPYDYPFIS

MYH3

301

P11055
YTSIAPLLNPFIYTL

OR6C6

276

A6NF89
PYRSPTYSVVIPSLQ

SOX30

441

O94993
ATVNYYVTPVQPLLA

TENT5B

401

Q96A09
IFYTPQYLNPSVISL

PRKAA1

241

Q13131
YLGITRPLTYPVRQN

HTR7

181

P34969
YLLDYPNNVLSVPTT

ANKHD1

686

Q8IWZ3
YYPINESLASLPLRV

CLPTM1

291

O96005
IQYQTVRYDILPLSP

CTDNEP1

36

O95476
APNLTIISPVYFYIN

TECTA

1536

O75443
LLAPATYRPVTYQSL

TBX10

316

O75333
PLYLIYPSVENVRTS

TDP1

436

Q9NUW8
PPNLDLLKYNRSYTV

ZNF684

141

Q5T5D7
PIEEQFPVLNVTRYY

ZMYND19

136

Q96E35
QEYILALADVPSSPY

NCAM2

486

O15394
LRIIPDSNYYFPTAE

SPIN4

176

Q56A73
DATNILVSPLVYLYP

STAT3

661

P40763
VYVQFIPLALYSNPS

TMEM131

861

Q92545
SSARVAPYRILYQTP

TBC1D9

56

Q6ZT07
INVLPGLPQYTSIYT

TTC3

1336

P53804
TSIYTPLASLSPEYQ

TTC3

1346

P53804
IFRETRNYPESYPQL

SCAI

556

Q8N9R8
QISLYAEYDRPNLLP

VPS41

616

P49754
TPPIVQSYAQPSLQY

SETD2

2316

Q9BYW2
NAIIRYPVEVISYQP

TMEM231

246

Q9H6L2
YFNPATLPLTQYLLT

ZGRF1

1551

Q86YA3
YLLTYSDNPQTVFPR

STARD7

286

Q9NQZ5
YLQRSDTAIIYPEAP

ZEB2

166

O60315
YSLSTNSPPLIQYVQ

TRIM64

386

A6NGJ6
KSEAPPIYLQVSSYQ

PRSS50

336

Q9UI38
YSLSTNSPPLIQYVQ

TRIM64B

386

A6NI03
ASVPVRSSPLYEYIQ

TCHH

1921

Q07283
LPHPLTRFQINYTEY

TCTN2

626

Q96GX1
VSKSRYLPTVVEYPN

VWA5B1

906

Q5TIE3
YLPTVVEYPNSAALR

VWA5B1

911

Q5TIE3
VVISVNPYRSLPIYS

MYO1B

51

O43795
NPYQLLSIYSPEHIR

MYO7A

106

Q13402
PSRNYTPYTRVLELT

MYZAP

446

P0CAP1