Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	TRPM2 RYR1 ITPR1 ITPR2	1.09e-05	18	159	4	GO:0015278
GeneOntologyMolecularFunction	L-leucine binding	UBR1 UBR2 SESN2	1.69e-05	7	159	3	GO:0070728
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	TRPM2 RYR1 ITPR1 ITPR2	1.03e-04	31	159	4	GO:0099604
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	TRPM2 RYR1 ITPR1 ITPR2	1.32e-04	33	159	4	GO:0005217
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR2	1.88e-04	3	159	2	GO:0005220
GeneOntologyBiologicalProcess	ubiquitin-dependent protein catabolic process via the N-end rule pathway	UBR1 UBR2 UBR3	1.75e-06	4	158	3	GO:0071596
GeneOntologyBiologicalProcess	regulation of catabolic process	ADCY10 RC3H2 TICAM1 ESRRB PSMD1 DAPK1 FASTKD5 FYCO1 PABPC1 TRIM5 ITPR1 CNOT6 USP8 PTPN3 WDR45 VPS13D RAB3GAP2 EIF4G1 UBR3 ZER1 SESN2 ABCD1 ULK1 AGAP2 ZC3HAV1 NLRP5	3.16e-06	1252	158	26	GO:0009894
GeneOntologyBiologicalProcess	positive regulation of catabolic process	ADCY10 RC3H2 TICAM1 ESRRB DAPK1 FYCO1 PABPC1 TRIM5 CNOT6 WDR45 VPS13D RAB3GAP2 UBR3 ZER1 SESN2 ABCD1 ULK1 ZC3HAV1	7.45e-06	701	158	18	GO:0009896
GeneOntologyBiologicalProcess	positive regulation of autophagy	TICAM1 DAPK1 FYCO1 TRIM5 WDR45 VPS13D RAB3GAP2 SESN2 ULK1	7.68e-06	173	158	9	GO:0010508
GeneOntologyBiologicalProcess	process utilizing autophagic mechanism	ADCY10 TICAM1 WDR81 DAPK1 FYCO1 HUWE1 TRIM5 ITPR1 WDR45 VPS13D AP5Z1 RAB3GAP2 EIF4G1 SESN2 ULK1 LRBA	4.10e-05	650	158	16	GO:0061919
GeneOntologyBiologicalProcess	autophagy	ADCY10 TICAM1 WDR81 DAPK1 FYCO1 HUWE1 TRIM5 ITPR1 WDR45 VPS13D AP5Z1 RAB3GAP2 EIF4G1 SESN2 ULK1 LRBA	4.10e-05	650	158	16	GO:0006914
GeneOntologyBiologicalProcess	regulation of autophagy	ADCY10 TICAM1 DAPK1 FYCO1 TRIM5 ITPR1 WDR45 VPS13D RAB3GAP2 EIF4G1 SESN2 ULK1	6.21e-05	400	158	12	GO:0010506
GeneOntologyBiologicalProcess	positive regulation of macroautophagy	FYCO1 WDR45 VPS13D RAB3GAP2 SESN2 ULK1	7.61e-05	92	158	6	GO:0016239
GeneOntologyBiologicalProcess	cellular response to L-leucine	UBR1 UBR2 SESN2	1.19e-04	13	158	3	GO:0071233
GeneOntologyBiologicalProcess	macroautophagy	ADCY10 WDR81 FYCO1 HUWE1 WDR45 VPS13D AP5Z1 RAB3GAP2 SESN2 ULK1 LRBA	1.50e-04	374	158	11	GO:0016236
GeneOntologyBiologicalProcess	maintenance of location in cell	KDELR3 ANK3 TRPM2 RYR1 ITPR1 ITPR2 VPS13D DIAPH1 SLC25A23	1.78e-04	259	158	9	GO:0051651
GeneOntologyBiologicalProcess	cellular response to nutrient levels	CDKN2B SRD5A1 IMPACT WDR45 ABCC8 EIF4G1 SESN2 ULK1 GCN1	1.94e-04	262	158	9	GO:0031669
GeneOntologyBiologicalProcess	response to L-leucine	UBR1 UBR2 SESN2	2.30e-04	16	158	3	GO:0043201
GeneOntologyBiologicalProcess	purine ribonucleotide transport	ADCY10 LRRC8D ABCD1 SLC25A23	2.44e-04	40	158	4	GO:0015868
GeneOntologyBiologicalProcess	autophagy of mitochondrion	ADCY10 HUWE1 WDR45 VPS13D ULK1 LRBA	2.48e-04	114	158	6	GO:0000422
GeneOntologyBiologicalProcess	regulation of GTPase activity	DOCK8 RALGAPA2 CHN1 PLXNB2 ALS2CL TBC1D16 RAB3GAP2 BCAR3 AGAP2 MTSS2	2.68e-04	335	158	10	GO:0043087
GeneOntologyBiologicalProcess	mitophagy	ADCY10 HUWE1 VPS13D ULK1 LRBA	2.77e-04	75	158	5	GO:0000423
GeneOntologyBiologicalProcess	adenine nucleotide transport	ADCY10 LRRC8D ABCD1 SLC25A23	2.96e-04	42	158	4	GO:0051503
GeneOntologyBiologicalProcess	neuron projection development	ADCY10 PRTG ABI3 WDR36 ANK3 NCKIPSD IMPACT LAMB1 LAMC2 CHAT CHN1 PLXNB2 DSCAML1 ITPR1 FBXO38 MRTFB LINGO1 AP5Z1 DIAPH1 ULK1 NEUROG3 CPEB1	3.28e-04	1285	158	22	GO:0031175
GeneOntologyBiologicalProcess	neuron projection retraction	ADCY10 DIAPH1	3.46e-04	4	158	2	GO:0106028
GeneOntologyBiologicalProcess	GCN2-mediated signaling	IMPACT GCN1	3.46e-04	4	158	2	GO:0140469
GeneOntologyBiologicalProcess	purine nucleotide transport	ADCY10 LRRC8D ABCD1 SLC25A23	3.54e-04	44	158	4	GO:0015865
GeneOntologyCellularComponent	spectrin-associated cytoskeleton	ANK1 ANK3 SPTBN2	3.64e-05	9	161	3	GO:0014731
GeneOntologyCellularComponent	laminin-2 complex	LAMB1 LAMC2	5.90e-05	2	161	2	GO:0005607
GeneOntologyCellularComponent	sarcoplasmic reticulum	ANK1 ANK3 RYR1 ITPR1 ITPR2 DMPK	6.12e-05	88	161	6	GO:0016529
GeneOntologyCellularComponent	sarcoplasm	ANK1 ANK3 RYR1 ITPR1 ITPR2 DMPK	2.56e-04	114	161	6	GO:0016528
GeneOntologyCellularComponent	omegasome	TRIM5 ULK1	5.81e-04	5	161	2	GO:1990462
GeneOntologyCellularComponent	cytoplasmic side of plasma membrane	CARMIL2 ANK1 RYR1 PTPN3 PTPN4 ALOX15 MTSS2	5.89e-04	185	161	7	GO:0009898
Domain	ARM-type_fold	CLTCL1 NBEAL1 DOCK8 PSMD1 HEATR5A PPP6R1 HUWE1 RALGAPA2 ITPR1 ITPR2 MROH1 TELO2 EIF4G1 DIAPH1 ZER1 CAB39L LRBA GCN1	6.96e-10	339	159	18	IPR016024
Domain	RIH_assoc-dom	RYR1 ITPR1 ITPR2	1.19e-05	6	159	3	IPR013662
Domain	Ins145_P3_rec	RYR1 ITPR1 ITPR2	1.19e-05	6	159	3	PF08709
Domain	RIH_assoc	RYR1 ITPR1 ITPR2	1.19e-05	6	159	3	PF08454
Domain	RIH_dom	RYR1 ITPR1 ITPR2	1.19e-05	6	159	3	IPR000699
Domain	Ins145_P3_rcpt	RYR1 ITPR1 ITPR2	1.19e-05	6	159	3	IPR014821
Domain	Ryanodine_recept-rel	RYR1 ITPR1 ITPR2	1.19e-05	6	159	3	IPR015925
Domain	-	RYR1 ITPR1 ITPR2	1.19e-05	6	159	3	1.25.10.30
Domain	RYDR_ITPR	RYR1 ITPR1 ITPR2	1.19e-05	6	159	3	PF01365
Domain	ARM-like	DOCK8 PSMD1 HEATR5A HUWE1 MROH1 TELO2 AP5Z1 ZER1 CAB39L LRBA GCN1	2.06e-05	270	159	11	IPR011989
Domain	ZnF_UBR1	UBR1 UBR2 UBR3	2.07e-05	7	159	3	SM00396
Domain	ZF_UBR	UBR1 UBR2 UBR3	2.07e-05	7	159	3	PS51157
Domain	zf-UBR	UBR1 UBR2 UBR3	2.07e-05	7	159	3	PF02207
Domain	Znf_UBR	UBR1 UBR2 UBR3	2.07e-05	7	159	3	IPR003126
Domain	BEACH	NBEAL1 WDR81 LRBA	4.90e-05	9	159	3	PS50197
Domain	Beach	NBEAL1 WDR81 LRBA	4.90e-05	9	159	3	PF02138
Domain	-	NBEAL1 WDR81 LRBA	4.90e-05	9	159	3	1.10.1540.10
Domain	Beach	NBEAL1 WDR81 LRBA	4.90e-05	9	159	3	SM01026
Domain	BEACH_dom	NBEAL1 WDR81 LRBA	4.90e-05	9	159	3	IPR000409
Domain	MIR	RYR1 ITPR1 ITPR2	6.95e-05	10	159	3	PF02815
Domain	MIR_motif	RYR1 ITPR1 ITPR2	6.95e-05	10	159	3	IPR016093
Domain	MIR	RYR1 ITPR1 ITPR2	6.95e-05	10	159	3	PS50919
Domain	MIR	RYR1 ITPR1 ITPR2	6.95e-05	10	159	3	SM00472
Domain	ClpS	UBR1 UBR2	7.20e-05	2	159	2	PF02617
Domain	Tyr_Pase_non-rcpt_typ-3/4	PTPN3 PTPN4	7.20e-05	2	159	2	IPR012151
Domain	ClpS_core	UBR1 UBR2	7.20e-05	2	159	2	IPR003769
Domain	EGF_LAM_2	STAB2 LAMB1 LAMC2 STAB1	1.17e-04	30	159	4	PS50027
Domain	EGF_LAM_1	STAB2 LAMB1 LAMC2 STAB1	1.17e-04	30	159	4	PS01248
Domain	-	PSMD1 HEATR5A MROH1 TELO2 AP5Z1 ZER1 CAB39L LRBA GCN1	1.23e-04	222	159	9	1.25.10.10
Domain	Ribosomal_L7/12_C/ClpS-like	UBR1 UBR2	2.15e-04	3	159	2	IPR014719
Domain	InsP3_rcpt-bd	ITPR1 ITPR2	2.15e-04	3	159	2	IPR000493
Domain	-	UBR1 UBR2	2.15e-04	3	159	2	3.30.1390.10
Domain	EGF_Lam	STAB2 LAMB1 LAMC2 STAB1	2.16e-04	35	159	4	SM00180
Domain	AAA	DNAH10 PEX1 PEX6 ABCB10 ABCC8 ABCD1 DNAH11	2.35e-04	144	159	7	SM00382
Domain	AAA+_ATPase	DNAH10 PEX1 PEX6 ABCB10 ABCC8 ABCD1 DNAH11	2.35e-04	144	159	7	IPR003593
Domain	Laminin_EGF	STAB2 LAMB1 LAMC2 STAB1	2.98e-04	38	159	4	IPR002049
Domain	FAS1	STAB2 STAB1	4.27e-04	4	159	2	SM00554
Domain	FAS1_domain	STAB2 STAB1	4.27e-04	4	159	2	IPR000782
Domain	-	STAB2 STAB1	4.27e-04	4	159	2	2.30.180.10
Domain	FAS1	STAB2 STAB1	4.27e-04	4	159	2	PS50213
Domain	Fasciclin	STAB2 STAB1	4.27e-04	4	159	2	PF02469
Domain	-	CARMIL2 LINGO2 LRRC8D CNOT6 FBXO38 LINGO1 CIITA LRRC53 ZER1 NLRP5	4.36e-04	321	159	10	3.80.10.10
Domain	L_dom-like	CARMIL2 LINGO2 LRRC8D CNOT6 FBXO38 LINGO1 CIITA LRRC53 ZER1 NLRP5	5.16e-04	328	159	10	IPR032675
Domain	DUF4704	NBEAL1 LRBA	7.08e-04	5	159	2	IPR031570
Domain	DUF4704	NBEAL1 LRBA	7.08e-04	5	159	2	PF15787
Domain	PH_BEACH	NBEAL1 LRBA	1.06e-03	6	159	2	PF14844
Domain	-	ANK1 ANK3 DAPK1 CASP12 NLRP5	1.19e-03	93	159	5	1.10.533.10
Domain	DEATH	ANK1 ANK3 DAPK1	1.52e-03	27	159	3	SM00005
Domain	DEATH-like_dom	ANK1 ANK3 DAPK1 CASP12 NLRP5	1.58e-03	99	159	5	IPR011029
Domain	ABC_TM1F	ABCB10 ABCC8 ABCD1	1.70e-03	28	159	3	PS50929
Domain	ABC1_TM_dom	ABCB10 ABCC8 ABCD1	1.70e-03	28	159	3	IPR011527
Domain	DHC_N1	DNAH10 DNAH11	1.95e-03	8	159	2	PF08385
Domain	PH-BEACH_dom	NBEAL1 LRBA	1.95e-03	8	159	2	IPR023362
Domain	-	NBEAL1 LRBA	1.95e-03	8	159	2	2.30.29.40
Domain	PH_BEACH	NBEAL1 LRBA	1.95e-03	8	159	2	PS51783
Domain	Dynein_heavy_dom-1	DNAH10 DNAH11	1.95e-03	8	159	2	IPR013594
Domain	Leu-rich_rpt	CARMIL2 LINGO2 LRRC8D CNOT6 LINGO1 CIITA LRRC53 NLRP5	2.28e-03	271	159	8	IPR001611
Domain	P-loop_NTPase	ADCY10 MYO1A DNAH10 PEX1 PEX6 DAPK1 KIF7 ABCB10 CIITA DQX1 ABCC8 ABCD1 AQR AGAP2 DNAH11 NLRP5	2.41e-03	848	159	16	IPR027417
Domain	ZU5	ANK1 ANK3	2.49e-03	9	159	2	SM00218
Domain	Death	ANK1 ANK3 DAPK1	2.74e-03	33	159	3	PF00531
Domain	ZU5	ANK1 ANK3	3.10e-03	10	159	2	PS51145
Domain	Ank_3	ANK1 ANK3	3.10e-03	10	159	2	PF13606
Domain	Laminin_EGF	LAMB1 LAMC2 STAB1	3.24e-03	35	159	3	PF00053
Domain	GFP-like	STAB2 STAB1	3.77e-03	11	159	2	IPR023413
Domain	-	STAB2 STAB1	3.77e-03	11	159	2	2.40.155.10
Domain	Death_domain	ANK1 ANK3 DAPK1	4.11e-03	38	159	3	IPR000488
Domain	DEATH_DOMAIN	ANK1 ANK3 DAPK1	4.11e-03	38	159	3	PS50017
Domain	EGF_dom	STAB2 STAB1	4.49e-03	12	159	2	IPR024731
Domain	WWE	HUWE1 ZC3HAV1	4.49e-03	12	159	2	PF02825
Domain	WWE-dom	HUWE1 ZC3HAV1	4.49e-03	12	159	2	IPR004170
Domain	WWE	HUWE1 ZC3HAV1	4.49e-03	12	159	2	PS50918
Domain	EGF_3	STAB2 STAB1	4.49e-03	12	159	2	PF12947
Domain	ZU5	ANK1 ANK3	4.49e-03	12	159	2	PF00791
Domain	ZU5_dom	ANK1 ANK3	4.49e-03	12	159	2	IPR000906
Domain	Link_dom	STAB2 STAB1	5.28e-03	13	159	2	IPR000538
Domain	Xlink	STAB2 STAB1	5.28e-03	13	159	2	PF00193
Domain	LINK_2	STAB2 STAB1	5.28e-03	13	159	2	PS50963
Domain	LINK	STAB2 STAB1	5.28e-03	13	159	2	SM00445
Domain	LINK_1	STAB2 STAB1	5.28e-03	13	159	2	PS01241
Domain	ABC_transporter_CS	ABCB10 ABCC8 ABCD1	5.45e-03	42	159	3	IPR017871
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DNAH11	6.13e-03	14	159	2	IPR024317
Domain	Dynein_HC_stalk	DNAH10 DNAH11	6.13e-03	14	159	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH10 DNAH11	6.13e-03	14	159	2	IPR013602
Domain	DHC_N2	DNAH10 DNAH11	6.13e-03	14	159	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH10 DNAH11	6.13e-03	14	159	2	IPR011704
Domain	MT	DNAH10 DNAH11	6.13e-03	14	159	2	PF12777
Domain	AAA_8	DNAH10 DNAH11	6.13e-03	14	159	2	PF12780
Domain	AAA_5	DNAH10 DNAH11	6.13e-03	14	159	2	PF07728
Domain	Znf_RING	UBR1 UBR2 RC3H2 VPS8 TRIM5 SYTL4 UBR3 NSMCE1	6.90e-03	326	159	8	IPR001841
Domain	DHC_fam	DNAH10 DNAH11	7.03e-03	15	159	2	IPR026983
Domain	Dynein_heavy	DNAH10 DNAH11	7.03e-03	15	159	2	PF03028
Domain	Dynein_heavy_dom	DNAH10 DNAH11	7.03e-03	15	159	2	IPR004273
Domain	LRR	LINGO2 LRRC8D CNOT6 LINGO1 CIITA LRRC53	7.56e-03	201	159	6	PS51450
Domain	-	WDR36 NBEAL1 WDR31 VPS8 WDR81 PLXNB2 WDR45 LRBA	7.80e-03	333	159	8	2.130.10.10
Domain	ABC_tran	ABCB10 ABCC8 ABCD1	7.91e-03	48	159	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCB10 ABCC8 ABCD1	7.91e-03	48	159	3	PS50893
Domain	WD40/YVTN_repeat-like_dom	WDR36 NBEAL1 WDR31 VPS8 WDR81 PLXNB2 WDR45 LRBA	8.07e-03	335	159	8	IPR015943
Domain	ABC_TRANSPORTER_1	ABCB10 ABCC8 ABCD1	8.38e-03	49	159	3	PS00211
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CLTCL1 PEX6 FYCO1 PPP6R1 HUWE1 RALGAPA2 PLXNB2 RYR1 ITPR2 FANCA TBC1D16 TNRC18 SLC38A10 SARS2 MROH1 EIF4G1 ZER1 ABCD1 ULK1 LRBA GCN1	5.26e-08	1105	162	21	35748872
Pubmed	Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.	RYR1 ITPR1 ITPR2	9.92e-08	3	162	3	23223241
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	WASHC4 VPS8 WDR81 PEX1 PEX6 FYCO1 SNX29 ITPR1 ITPR2 WDR45 VPS13D YKT6 LRBA ZC3HAV1	1.18e-07	504	162	14	34432599
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR1 ITPR1 ITPR2	3.95e-07	4	162	3	19120137
Pubmed	Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels.	ANK1 ANK3 CHAT	3.95e-07	4	162	3	34180393
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	WDR36 PSMD1 FASTKD5 PRPF8 INTS10 YKT6 ABCB10 TELO2 AP5Z1 RAB3GAP2 EIF4G1 DIAPH1 TIMM44 AQR	4.19e-07	560	162	14	35241646
Pubmed	Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.	STAB2 ABI3 DNAH10 DNER LAMB1 LINGO2 RALGAPA2 TRIM5 SLC38A10	4.36e-07	199	162	9	23382691
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	UBR2 RNGTT ANK3 SPTBN2 PSMD1 PPP6R1 HUWE1 KIF7 ITPR1 ITPR2 FBXO38 PTPN3 PTPN4 MTMR11 TELO2 UBR3 UXT GCN1 HDLBP	4.93e-07	1049	162	19	27880917
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	KDELR3 RC3H2 ANK1 LAMC2 HUWE1 PRPF8 TNRC18 ABCB10 SACS AP5Z1 EIF4G1	5.05e-07	332	162	11	37433992
Pubmed	Functional proteomics mapping of a human signaling pathway.	NPR1 WASHC4 ANK3 DOCK8 VPS8 PEX6 PSMD1 HUWE1 MTMR11 MRTFB EIF4G1 DIAPH1 BRD1 HDLBP	7.94e-07	591	162	14	15231748
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	WDR36 ANK3 SPTBN2 LAMB1 FASTKD5 PPP6R1 PRPF8 PLXNB2 SNX29 KIF7 ITPR1 ITPR2 SARS2 YKT6 ABCB10 SACS TELO2 RAB3GAP2 TIMM44 AQR ZC3HAV1 HDLBP	1.72e-06	1487	162	22	33957083
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 ITPR1 ITPR2	1.96e-06	6	162	3	23463619
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 ITPR1 ITPR2	1.96e-06	6	162	3	25966694
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 ITPR1 ITPR2	1.96e-06	6	162	3	20519450
Pubmed	Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway.	UBR1 UBR2 UBR3	1.96e-06	6	162	3	10805755
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 ITPR1 ITPR2	1.96e-06	6	162	3	16844763
Pubmed	Defining the membrane proteome of NK cells.	ABI3 CLTCL1 CARMIL2 DOCK8 PSMD1 FYCO1 HUWE1 PRPF8 LRRC8D PABPC1 ITPR1 ITPR2 CNOT6 EIF4G1 ABCD1 LRBA GCN1 AQR AGAP2	2.41e-06	1168	162	19	19946888
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 ITPR1 ITPR2	3.42e-06	7	162	3	11860456
Pubmed	Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.	UBR1 UBR2 UBR3	3.42e-06	7	162	3	21816346
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	CLTCL1 PRPF8 EIF4G1 DIAPH1 DMPK GCN1 AQR HDLBP	5.18e-06	202	162	8	24639526
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	CLTCL1 ANK3 WDR81 PSMD1 DAPK1 FYCO1 HUWE1 PRPF8 PABPC1 RYR1 EIF4G1 DIAPH1 LRBA GCN1 HDLBP	6.20e-06	807	162	15	30575818
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	UBR1 UBR2 UBR3	8.16e-06	9	162	3	17855541
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	NBEAL1 VPS8 PLBD2 SNX29 YKT6 SESN2 ULK1 LRBA ZC3HAV1	8.32e-06	285	162	9	34369648
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	RNGTT ITPR1 FANCA TELO2 DIAPH1 TIMM44	9.69e-06	104	162	6	31240132
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	RNGTT ANK1 SPTBN2 BRME1 PPP6R1 HUWE1 PRPF8 CHN1 DSCAML1 RYR1 ITPR2 FANCA SLC38A10 DQX1	9.89e-06	736	162	14	29676528
Pubmed	Cell organization, growth, and neural and cardiac development require αII-spectrin.	ANK1 ANK3 SPTBN2	1.16e-05	10	162	3	22159418
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	UBR1 RC3H2 PEX1 PEX6 LAMC2 PPP6R1 ITPR1 FANCA TMEM62 ULK1 CMTR2 AQR ZC3HAV1	1.23e-05	650	162	13	38777146
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	NBEAL1 ITPR1 VPS13D MRTFB YKT6 RAB3GAP2 EIF4G1 ABCD1 LRBA GCN1 ZC3HAV1 HDLBP	1.57e-05	568	162	12	37774976
Pubmed	KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.	UBR1 UBR2 SARS2 UBR3	1.67e-05	33	162	4	25582440
Pubmed	HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.	UBR1 UBR2 UBR3	2.12e-05	12	162	3	17360488
Pubmed	Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase.	UBR1 UBR2	2.16e-05	2	162	2	28392261
Pubmed	Disruption of a PEX1-PEX6 interaction is the most common cause of the neurologic disorders Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile Refsum disease.	PEX1 PEX6	2.16e-05	2	162	2	9671729
Pubmed	FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.	STAB2 STAB1	2.16e-05	2	162	2	12473645
Pubmed	Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway.	UBR1 UBR2	2.16e-05	2	162	2	20298436
Pubmed	LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease.	LINGO2 LINGO1	2.16e-05	2	162	2	20369371
Pubmed	Spectrum of PEX1 and PEX6 variants in Heimler syndrome.	PEX1 PEX6	2.16e-05	2	162	2	27302843
Pubmed	Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.	ITPR1 ITPR2	2.16e-05	2	162	2	15201137
Pubmed	Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).	UBR1 UBR2	2.16e-05	2	162	2	16311597
Pubmed	Long-term potentiation and long-term depression in hippocampal CA1 neurons of mice lacking the IP(3) type 1 receptor.	RYR1 ITPR1	2.16e-05	2	162	2	12654335
Pubmed	β-III spectrin underpins ankyrin R function in Purkinje cell dendritic trees: protein complex critical for sodium channel activity is impaired by SCA5-associated mutations.	ANK1 SPTBN2	2.16e-05	2	162	2	24603075
Pubmed	Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.	ITPR1 ITPR2	2.16e-05	2	162	2	23582047
Pubmed	Mechanism for phosphatidylserine-dependent erythrophagocytosis in mouse liver.	STAB2 STAB1	2.16e-05	2	162	2	21427291
Pubmed	Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding.	STAB2 STAB1	2.16e-05	2	162	2	15572036
Pubmed	Phenotypical and biochemical characterization of murine psoriasiform and fibrotic skin disease models in Stabilin-deficient mice.	STAB2 STAB1	2.16e-05	2	162	2	38946049
Pubmed	Frequent CDKN2B/P15 and DAPK1 methylation in duodenal follicular lymphoma is related to duodenal reactive lymphoid hyperplasia.	CDKN2B DAPK1	2.16e-05	2	162	2	38925973
Pubmed	FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities.	STAB2 STAB1	2.16e-05	2	162	2	12077138
Pubmed	Phenotype-genotype relationships in peroxisome biogenesis disorders of PEX1-defective complementation group 1 are defined by Pex1p-Pex6p interaction.	PEX1 PEX6	2.16e-05	2	162	2	11439091
Pubmed	Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.	ITPR1 ITPR2	2.16e-05	2	162	2	19120126
Pubmed	Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing.	PRPF8 ULK1	2.16e-05	2	162	2	30103670
Pubmed	Ryanodine receptor-ankyrin interaction regulates internal Ca2+ release in mouse T-lymphoma cells.	ANK1 RYR1	2.16e-05	2	162	2	7629097
Pubmed	Scavenging Endothelium of Pancreatic Islets: Differential Expression of Stabilin-1 and Stabilin-2 in Mice and Humans.	STAB2 STAB1	2.16e-05	2	162	2	27977633
Pubmed	Heimler Syndrome Is Caused by Hypomorphic Mutations in the Peroxisome-Biogenesis Genes PEX1 and PEX6.	PEX1 PEX6	2.16e-05	2	162	2	26387595
Pubmed	Poly(A) binding protein abundance regulates eukaryotic translation initiation factor 4F assembly in human cytomegalovirus-infected cells.	PABPC1 EIF4G1	2.16e-05	2	162	2	22431630
Pubmed	Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study.	STAB2 STAB1	2.16e-05	2	162	2	33008099
Pubmed	Exploring the transcriptomic network of multi-ligand scavenger receptor Stabilin-1- and Stabilin-2-deficient liver sinusoidal endothelial cells.	STAB2 STAB1	2.16e-05	2	162	2	33130055
Pubmed	Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.	KIF7 UBR3	2.16e-05	2	162	2	27195754
Pubmed	Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.	UBR1 UBR2	2.16e-05	2	162	2	16606826
Pubmed	An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.	ITPR1 ITPR2	2.16e-05	2	162	2	18708078
Pubmed	Recruiting mechanism of the AAA peroxins, Pex1p and Pex6p, to Pex26p on the peroxisomal membrane.	PEX1 PEX6	2.16e-05	2	162	2	21362118
Pubmed	Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia.	UBR1 UBR2	2.16e-05	2	162	2	15548684
Pubmed	Epstein-Barr Virus Protein EB2 Stimulates Translation Initiation of mRNAs through Direct Interactions with both Poly(A)-Binding Protein and Eukaryotic Initiation Factor 4G.	PABPC1 EIF4G1	2.16e-05	2	162	2	29142127
Pubmed	Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors.	STAB2 STAB1	2.16e-05	2	162	2	21293057
Pubmed	The peroxisomal disorder spectrum and Heimler syndrome: Deep phenotyping and review of the literature.	PEX1 PEX6	2.16e-05	2	162	2	32866347
Pubmed	Recognition of eIF4G by rotavirus NSP3 reveals a basis for mRNA circularization.	PABPC1 EIF4G1	2.16e-05	2	162	2	12086624
Pubmed	A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding.	PABPC1 EIF4G1	2.16e-05	2	162	2	16772376
Pubmed	Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues.	STAB2 STAB1	2.16e-05	2	162	2	11829752
Pubmed	A cytoplasmic AAA family peroxin, Pex1p, interacts with Pex6p.	PEX1 PEX6	2.16e-05	2	162	2	9588209
Pubmed	Structural basis of substrate recognition and specificity in the N-end rule pathway.	UBR1 UBR2	2.16e-05	2	162	2	20835242
Pubmed	Severe early onset retinitis pigmentosa in a Moroccan patient with Heimler syndrome due to novel homozygous mutation of PEX1 gene.	PEX1 PEX6	2.16e-05	2	162	2	27633571
Pubmed	Structural Mapping of Missense Mutations in the Pex1/Pex6 Complex.	PEX1 PEX6	2.16e-05	2	162	2	31374812
Pubmed	Expression and reconstitution of the bioluminescent Ca(2+) reporter aequorin in human embryonic stem cells, and exploration of the presence of functional IP3 and ryanodine receptors during the early stages of their differentiation into cardiomyocytes.	RYR1 ITPR1	2.16e-05	2	162	2	27430888
Pubmed	Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis.	PEX1 PEX6	2.16e-05	2	162	2	26476099
Pubmed	Sestrin2 Phosphorylation by ULK1 Induces Autophagic Degradation of Mitochondria Damaged by Copper-Induced Oxidative Stress.	SESN2 ULK1	2.16e-05	2	162	2	32854424
Pubmed	Interdomain allostery promotes assembly of the poly(A) mRNA complex with PABP and eIF4G.	PABPC1 EIF4G1	2.16e-05	2	162	2	23041282
Pubmed	Association of Differentially Altered Liver Fibrosis with Deposition of TGFBi in Stabilin-Deficient Mice.	STAB2 STAB1	2.16e-05	2	162	2	37446152
Pubmed	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.	PABPC1 CNOT6 EIF4G1	3.48e-05	14	162	3	19716330
Pubmed	Comparative analysis of apoptosis and inflammation genes of mice and humans.	ANK3 DAPK1 CASP12 CIITA NLRP5	3.74e-05	80	162	5	12819136
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	PSMD1 HUWE1 PRPF8 PABPC1 YKT6 TELO2 EIF4G1 DIAPH1 LRBA TIMM44 GCN1 ZC3HAV1	4.85e-05	638	162	12	33239621
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	RNGTT PEX1 PSMD1 FASTKD5 ITPR2 EIF4G1	5.02e-05	139	162	6	25476789
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	PSMD1 HUWE1 MRTFB YKT6 TELO2 EIF4G1 LRBA GCN1 ZC3HAV1 HDLBP	5.26e-05	449	162	10	31732153
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CARMIL2 NCKIPSD RTKN PABPC1 FSIP2 USP8 PTPN3 VPS13D RAB3GAP2 EIF4G1 BRD1 AQR MTSS2 ZC3HAV1	5.50e-05	861	162	14	36931259
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR1 ITPR2	6.45e-05	3	162	2	10874040
Pubmed	Highly oxidized albumin is cleared by liver sinusoidal endothelial cells via the receptors stabilin-1 and -2.	STAB2 STAB1	6.45e-05	3	162	2	37926735
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR1 ITPR2	6.45e-05	3	162	2	20395455
Pubmed	De novo point mutations in patients diagnosed with ataxic cerebral palsy.	SPTBN2 ITPR1	6.45e-05	3	162	2	25981959
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR1 ITPR2	6.45e-05	3	162	2	17437169
Pubmed	βIV Spectrinopathies Cause Profound Intellectual Disability, Congenital Hypotonia, and Motor Axonal Neuropathy.	ANK1 ANK3	6.45e-05	3	162	2	29861105
Pubmed	A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier.	ANK1 ANK3	6.45e-05	3	162	2	25362473
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR1 ITPR2	6.45e-05	3	162	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR1 ITPR2	6.45e-05	3	162	2	36350267
Pubmed	Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability.	ITPR1 ITPR2	6.45e-05	3	162	2	32320395
Pubmed	The versatility and universality of calcium signalling.	ITPR1 ITPR2	6.45e-05	3	162	2	11413485
Pubmed	Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p.	PEX1 PEX6	6.45e-05	3	162	2	16854980
Pubmed	Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis.	MMP13 ALOX15	6.45e-05	3	162	2	19296842
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	6.45e-05	3	162	2	26009177
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR1 ITPR2	6.45e-05	3	162	2	1693919
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR1 ITPR2	6.45e-05	3	162	2	23955339
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR1 ITPR2	6.45e-05	3	162	2	31979185
Pubmed	BRCA1-Dependent Translational Regulation in Breast Cancer Cells.	PABPC1 EIF4G1	6.45e-05	3	162	2	23805307
Pubmed	Identification of distinct ChAT⁺ neurons and activity-dependent control of postnatal SVZ neurogenesis.	ANK3 CHAT	6.45e-05	3	162	2	24880216
Interaction	EEF1AKMT3 interactions	RNGTT WASHC4 NAB2 WDR81 PEX1 HUWE1 RTKN ALS2CL FANCA TELO2 ABCD1 GCN1 AQR HDLBP	1.41e-06	364	161	14	int:EEF1AKMT3
Interaction	MEX3A interactions	KDELR3 RC3H2 ANK1 LAMC2 HUWE1 PRPF8 PABPC1 CNOT6 TNRC18 ABCB10 SACS AP5Z1 EIF4G1 ZC3HAV1	2.63e-06	384	161	14	int:MEX3A
Interaction	MGARP interactions	PEX1 PEX6 FASTKD5 PPP6R1 SLC38A10 MROH1 TELO2 ZER1 ABCD1 SLC25A23	1.22e-05	222	161	10	int:MGARP
Interaction	NPTN interactions	CLTCL1 NBEAL1 FASTKD5 ACAD10 HUWE1 FANCA MROH1 TELO2 AP5Z1 GCN1 AGAP2	1.51e-05	278	161	11	int:NPTN
Interaction	GPR45 interactions	KDELR3 VPS8 PEX1 PEX6 FASTKD5 ACAD10 PPP6R1 FANCA MROH1 TELO2 GCN1	3.05e-05	300	161	11	int:GPR45
Interaction	TOP3B interactions	RC3H2 CLTCL1 WDR36 SPTBN2 PEX6 FYCO1 PPP6R1 HUWE1 RALGAPA2 PLXNB2 PABPC1 RYR1 ITPR2 FANCA TBC1D16 TNRC18 SLC38A10 SARS2 MROH1 EIF4G1 ZER1 ABCD1 ULK1 LRBA GCN1 ZC3HAV1 HDLBP	3.97e-05	1470	161	27	int:TOP3B
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR1 UBR2 UBR3	6.18e-06	7	103	3	785
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEAL1 WDR81 LRBA	1.47e-05	9	103	3	1230
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR2	9.61e-05	3	103	2	297
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 ESRRB LAMB1 DAPK1 PTPN4 LINGO1 LRBA PDE7B	4.75e-07	189	162	8	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	Control-Myeloid-Monocyte-derived_macrophages\|Control / group, cell type (main and fine annotations)	DOCK8 OLFML2B TRPM2 SNX29 RYR1 ITPR2 STAB1 CIITA	5.57e-07	193	162	8	a6b3bd01e585e2e3fbe9bf693a2e385773123f8e
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXNB2 SLC38A10 MROH1 SYTL4 ABCC8 EIF4G1 CPEB1 HDLBP	5.57e-07	193	162	8	471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCell	COVID-19-Myeloid-Monocyte-derived_macrophages\|COVID-19 / group, cell type (main and fine annotations)	DOCK8 OLFML2B TRPM2 DAPK1 SNX29 ITPR2 STAB1 CIITA	6.02e-07	195	162	8	c172c5599379c29123340621a36bfb1fc90c2115
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 ESRRB LAMB1 DAPK1 DSCAML1 SNX29 PTPN3 LRBA	6.02e-07	195	162	8	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FASTKD5 CCDC51 SNX29 PTPN4 CMTR2 SLC25A23 GASK1A	3.03e-06	170	162	7	070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCell	E17.5-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ANK3 BSPRY CPN1 ACSS2 RTKN SNX29 QPCT	3.53e-06	174	162	7	68914ec843f58ecff3e6412544a341daf8a01cac
ToppCell	Bronchial-10x5prime-Stromal-Schwann-Schwann_nonmyelinating\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ANK3 RTKN TBC1D16 SACS CAB39L MTSS2	4.25e-06	116	162	6	b0a3c109c5f20ab699e53bf8ab3903d102f5f315
ToppCell	facs-Heart-LA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CATSPERZ ANKK1 UBR1 CHN1 LRRC8D BCAR3 AGAP2	5.47e-06	186	162	7	e2ba9f3518d87a44537a57a648df17ab98fbbb39
ToppCell	facs-Heart-LA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CATSPERZ ANKK1 UBR1 CHN1 LRRC8D BCAR3 AGAP2	5.47e-06	186	162	7	fda3415222f688ef5cd8de4b0b79daa2493c585f
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	UBR2 WDR36 DOCK8 HUWE1 ITPR2 CIITA LRBA	5.47e-06	186	162	7	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	UBR1 NBEAL1 HEATR5A CNOT6 FBXO38 USP8 VPS13D	5.47e-06	186	162	7	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-B_cells-DZ_GC_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL9A3 CLTCL1 RNGTT ANK1 PABPC1 CFAP119 NSMCE1	5.87e-06	188	162	7	9a10536afa2dea34c78421d36564cfd8252afe45
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	NPR1 DAPK1 RALGAPA2 CHN1 ITPR2 MRTFB PDE7B	6.74e-06	192	162	7	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXNB2 SLC38A10 MROH1 SYTL4 ABCC8 EIF4G1 HDLBP	6.97e-06	193	162	7	fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 ESRRB LAMB1 DAPK1 SNX29 PTPN3 LRBA	7.21e-06	194	162	7	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK8 OLFML2B TRPM2 RYR1 ITPR2 STAB1 CIITA	7.46e-06	195	162	7	312d9625655b38f1a7c2bf8f8bb7b667ebdf9617
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HK3 DOCK8 TRPM2 ADA2 RYR1 STAB1 CIITA	7.71e-06	196	162	7	4370473693d2dd4a8c451a4c477eb79baa33ae12
ToppCell	COVID-19-lung-Macrophage_metabolically_active\|COVID-19 / Disease (COVID-19 only), tissue and cell type	HK3 DOCK8 OLFML2B TRPM2 STAB1 LINGO1 CIITA	7.71e-06	196	162	7	1b7928f4eee94d4bb6ea410bab68a471dba12979
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 ESRRB LAMB1 DAPK1 SNX29 PTPN3 LRBA	7.71e-06	196	162	7	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK8 TRPM2 DAPK1 RYR1 ITPR2 STAB1 CIITA	7.97e-06	197	162	7	10190b877bf46ba2163d203df9dd3b498c66e52f
ToppCell	nucseq-Immune-Immune_Myeloid-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	OLFML2B TRPM2 SNX29 ITPR2 STAB1 TBC1D16 CIITA	7.97e-06	197	162	7	6f41c8f815851968849428ec92c16745bd01a3fb
ToppCell	nucseq-Immune-Immune_Myeloid-IM-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	OLFML2B TRPM2 SNX29 ITPR2 STAB1 TBC1D16 CIITA	7.97e-06	197	162	7	304044ace926943b8eb588f686ecbe5d1689a809
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Crym_(Crym)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	STAB2 CYP21A2 TMEM89 GASK1A ALOX15	1.24e-05	82	162	5	bc4e309c0128d126c47895e88d2250324c6ff81a
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Crym_(Crym)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	STAB2 CYP21A2 TMEM89 GASK1A ALOX15	1.24e-05	82	162	5	9cd1b8a580566904a1ca0d4b5c48b2bf12a8898b
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Crym_(Crym)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	STAB2 CYP21A2 TMEM89 GASK1A ALOX15	1.24e-05	82	162	5	0fb857a83f61d8c26be1b151903f4e6dc69397f9
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Rln3_(parabrachial_pigmented_nucleus_(PBP))-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CPN1 RYR1 SYTL4 DQX1 MMP13	1.75e-05	88	162	5	b4620e79ea80681305434707e87cb02a7c6a5e4f
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Rln3_(parabrachial_pigmented_nucleus_(PBP))--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CPN1 RYR1 SYTL4 DQX1 MMP13	1.75e-05	88	162	5	7992f8e621edf464bffcb70a6cc5f3b60c1d96f8
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Rln3_(parabrachial_pigmented_nucleus_(PBP))\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CPN1 RYR1 SYTL4 DQX1 MMP13	1.75e-05	88	162	5	b7b55f51af8ffa82813a4747580985a430da9ed1
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	DNAH10 LAMC2 LRBA CFAP46 CPEB1 DNAH11	2.31e-05	156	162	6	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	droplet-Marrow-BM-1m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL9A3 WDR36 ANK1 BRME1 QPCT DNAH11	3.50e-05	168	162	6	2e88d9cb7c80a4656fab290db8b45a5a0599d769
ToppCell	P28-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LAMC2 CPN1 PLXNB2 TMEM62 TNRC18 DMPK	3.50e-05	168	162	6	8c8dbdbc7053f34e4ca0c5067af502fbea109fc1
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANK1 MYOZ2 ZC4H2 ITPR1 SACS ABCC8	4.54e-05	176	162	6	4ed73c73972334f6dc4229920205547823252fa0
ToppCell	PBMC-Severe-cDC_11\|Severe / Compartment, Disease Groups and Clusters	CDKN2B CLTCL1 CARMIL2 WDR31 LAMB1 MTSS2	4.84e-05	178	162	6	0667abc05eb2254710b9c648c65b7cfdfe7831b7
ToppCell	normal_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_LZ\|normal_Lymph_Node / Location, Cell class and cell subclass	RNGTT DNER FANCA SYTL4 QPCT BCAR3	4.84e-05	178	162	6	d75057e7463558a0d3cebde3c30befbf4704dd9a
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCKIPSD RALGAPA2 STAB1 TBC1D16 AP5Z1 LRBA	4.99e-05	179	162	6	2c3abd646d2c8992e8ff76a824eab5beba8ba4c6
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCKIPSD RALGAPA2 STAB1 TBC1D16 AP5Z1 LRBA	4.99e-05	179	162	6	6eb84fe9691ad40127b2d1f1c672428333c8fab4
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	ANK1 ARSK PSMD1 DIAPH1 XKR5 HDLBP	5.15e-05	180	162	6	81d60f0fa9e3b5bfcec85139a0a49e9130145f0e
ToppCell	IIH-Treg-proli_CD4\|IIH / Condition, Cell_class and T cell subcluster	SRD5A1 PEX1 PEX6 LAMB1 LRRC8D TNRC18	5.47e-05	182	162	6	5c7d02da9ca2bca49db9832704b6894dfaa08a71
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KDELR3 LAMB1 BPIFA1 CHN1 KIF7 DMPK	5.81e-05	184	162	6	e33e2a887aafba7b6a31f00bb0dbe974b4359fd6
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	UBR2 WDR36 DOCK8 HUWE1 CIITA LRBA	5.99e-05	185	162	6	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	droplet-Tongue-nan-24m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKK1 ANK3 DOCK8 OTOP2 STAB1 DMPK	6.17e-05	186	162	6	18c06041c6c8a0ebac17b3c8aaebd67e652d315a
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LINGO2 CHN1 ITPR1 PTPN3 MRTFB LINGO1	6.36e-05	187	162	6	f18628ffc7ff7c762b8339ba8822cf0c3157f469
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LINGO2 CHN1 ITPR1 PTPN3 MRTFB LINGO1	6.55e-05	188	162	6	50c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LINGO2 CHN1 ITPR1 MRTFB LINGO1 PDE7B	6.74e-05	189	162	6	c3df0e3c50af8f1cfb4d790e668bd7f42b276992
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRPM2 SNX29 RYR1 ITPR2 STAB1 CIITA	6.94e-05	190	162	6	f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ESRRB LINGO2 ITPR1 PTPN4 SYTL4 LRBA	7.15e-05	191	162	6	963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	UBR1 UBR2 WDR36 HUWE1 CIITA LRBA	7.15e-05	191	162	6	9454f642c3621370fa23640b631301346b300950
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK8 OLFML2B TRPM2 RYR1 STAB1 CIITA	7.15e-05	191	162	6	24d75b7e1d6fb9d24aa7844f584ee888a449841f
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	NBEAL1 HEATR5A HUWE1 CNOT6 USP8 AQR	7.57e-05	193	162	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ANK3 DNAH10 MRTFB ALOX15 CFAP46 DNAH11	7.57e-05	193	162	6	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 ESRRB LAMB1 SNX29 PTPN3 LRBA	7.57e-05	193	162	6	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OLFML2B DAPK1 ADA2 RYR1 STAB1 TBC1D16	7.79e-05	194	162	6	7c7091de47359760003e910cfbe63db5c99410d6
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D231\|Adult / Lineage, Cell type, age group and donor	TRPM2 PLBD2 SNX29 RYR1 STAB1 CIITA	7.79e-05	194	162	6	800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical\|TCGA-Thryoid / Sample_Type by Project: Shred V9	SPTBN2 NAB2 PLXNB2 RYR1 MTMR11 QPCT	7.79e-05	194	162	6	b46c54802b8d1e0a0a17f9ed8e82eaf5e7f4849d
ToppCell	Differ-Basal\|World / shred by cell class for mouse tongue	KDELR3 ANK3 DOCK8 OTOP2 STAB1 CAB39L	7.79e-05	194	162	6	851eff82c9f3d44c86e3e127a804bbd1fced6a7c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK8 TRPM2 ADA2 RYR1 STAB1 CIITA	8.01e-05	195	162	6	ce8215d503cad3a9bc7d5d2be4adb57408015593
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK8 TRPM2 ADA2 RYR1 STAB1 CIITA	8.01e-05	195	162	6	09df40ff9b493170861b3f6e57a942a834655b5c
ToppCell	COVID-19-Myeloid-Transitioning_MDM\|COVID-19 / group, cell type (main and fine annotations)	DOCK8 TRPM2 VPS8 SNX29 STAB1 CIITA	8.24e-05	196	162	6	4929cfed1f150c1fde4d79cb49895c2ea467a18f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 LAMB1 DAPK1 SNX29 PTPN3 LRBA	8.24e-05	196	162	6	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	HK3 DOCK8 OLFML2B TRPM2 STAB1 CIITA	8.24e-05	196	162	6	7026c1fc33425e5476063d17c79e4b79356a9e01
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 DNER LAMB1 DAPK1 DSCAML1 PTPN3	8.47e-05	197	162	6	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OLFML2B TRPM2 DAPK1 ADA2 STAB1 CIITA	8.47e-05	197	162	6	e698a0bbb20bd4868ff4348f2ac9f609942b55fa
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK8 TRPM2 ADA2 RYR1 STAB1 CIITA	8.71e-05	198	162	6	96883ad8e189a46ed5b7eaafc0543e53682d26ed
ToppCell	COPD-Myeloid-Macrophage\|Myeloid / Disease state, Lineage and Cell class	OLFML2B TRPM2 PLBD2 SNX29 STAB1 CIITA	8.96e-05	199	162	6	1cf1b2d6debf9e3389f1829dcaa2857e9533a080
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK8 TRPM2 RYR1 ITPR2 STAB1 CIITA	8.96e-05	199	162	6	f34c15df58fbdc6c90e30800e26fabbf828ad10b
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK8 TRPM2 RYR1 ITPR2 STAB1 CIITA	8.96e-05	199	162	6	5ceeed92f831d068ff4bb3994f420002338330e7
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	UBR2 ANK3 ITPR2 LINGO1 UBR3 LRBA	8.96e-05	199	162	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	control-HLA-DR-_S100A+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HK3 PLXNB2 STAB1 TNRC18 MTMR11 QPCT	9.21e-05	200	162	6	107a0665fb20247511a430178effd7630a619488
ToppCell	control-HLA-DR-_S100A+_Monocyte\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HK3 PLXNB2 STAB1 TNRC18 MTMR11 QPCT	9.21e-05	200	162	6	9e3e13a68bc1110fa000ec2d80f4c654ddbce17e
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-9\|TCGA-Brain / Sample_Type by Project: Shred V9	MYOZ2 HEATR5A RYR1 VPS13D SYTL4	1.31e-04	134	162	5	2647453f44b0e0a8f27ef9bba750e99eb40efc8b
Drug	IPMP	PEX6 ABCC8 QPCT ABCD1	4.20e-06	16	162	4	CID000033166
Drug	Mefenamic acid [61-68-7]; Down 200; 16.6uM; PC3; HT_HG-U133A	NAB2 ITPR1 FANCA TELO2 AP5Z1 DIAPH1 AQR CPEB1 HDLBP	1.18e-05	196	162	9	1821_DN
Drug	Cyproterone acetate [427-51-0]; Up 200; 9.6uM; MCF7; HT_HG-U133A	COL9A3 SPTBN2 LAMC2 ITPR2 VPS13D CIITA RAB3GAP2 ZER1 CPEB1	1.27e-05	198	162	9	6806_UP
Drug	Pyrilamine maleate [59-33-6]; Down 200; 10uM; PC3; HT_HG-U133A	RNGTT SRD5A1 PEX1 PEX6 ITPR1 ITPR2 PRUNE1 AP5Z1 TIMM44	1.27e-05	198	162	9	5869_DN
Drug	Streptozotocin [18883-66-4]; Down 200; 15uM; PC3; HT_HG-U133A	RC3H2 PEX1 ALS2CL PRUNE1 VPS13D TMEM62 CPEB1 ZC3HAV1 HDLBP	1.33e-05	199	162	9	5836_DN
Disease	Hypoxic Brain Damage	ITPR1 ITPR2	2.81e-05	2	157	2	C1140716
Disease	Anoxic Encephalopathy	ITPR1 ITPR2	2.81e-05	2	157	2	C0003132
Disease	Brain Hypoxia	ITPR1 ITPR2	2.81e-05	2	157	2	C1527348
Disease	Anoxia of brain	ITPR1 ITPR2	2.81e-05	2	157	2	C0995195
Disease	Deafness, enamel hypoplasia, nail defect syndrome	PEX1 PEX6	2.81e-05	2	157	2	cv:C1856186
Disease	Deafness enamel hypoplasia nail defects	PEX1 PEX6	8.41e-05	3	157	2	C1856186
Disease	Partial Fetal Alcohol Syndrome	ANK3 BPIFA1	2.78e-04	5	157	2	C3661483
Disease	Alcohol Related Neurodevelopmental Disorder	ANK3 BPIFA1	2.78e-04	5	157	2	C0814154
Disease	hyperinsulinemic hypoglycemia (implicated_via_orthology)	HK3 ABCC8	2.78e-04	5	157	2	DOID:13317 (implicated_via_orthology)
Disease	serum gamma-glutamyl transferase measurement	UBR1 OR5B12 CYP21A2 CPN1 ITPR1 STAB1 PTPN3 SYTL4 ZER1 ABCD1 ULK1 LRBA GCN1 HDLBP	3.95e-04	914	157	14	EFO_0004532
Disease	2,3-dihydroxy-5-methylthio-4-pentenoate (DMTPA) measurement	CYP21A2 PEX6	4.16e-04	6	157	2	EFO_0800111
Disease	Alcohol Related Birth Defect	ANK3 BPIFA1	4.16e-04	6	157	2	C3146244
Disease	serum IgG glycosylation measurement	STAB2 ABI3 RNGTT DNAH10 DNER LAMB1 LINGO2 RALGAPA2 TRIM5 SLC38A10	5.16e-04	523	157	10	EFO_0005193
Disease	Adrenoleukodystrophy	PEX1 ABCD1	5.80e-04	7	157	2	C0162309
Disease	prostate cancer (implicated_via_orthology)	SRD5A1 PRPF8 HDLBP	7.17e-04	33	157	3	DOID:10283 (implicated_via_orthology)
Disease	Heart Failure, Diastolic	PTPN3 WDR45 ALOX15	7.17e-04	33	157	3	C1135196
Disease	peroxisomal biogenesis disorder (implicated_via_orthology)	PEX1 PEX6	7.71e-04	8	157	2	DOID:0080377 (implicated_via_orthology)
Disease	interleukin 27 receptor subunit alpha measurement	BRME1 CPN1	7.71e-04	8	157	2	EFO_0008183
Disease	hepatocyte growth factor-like protein measurement	NCKIPSD ALS2CL TMEM89	1.09e-03	38	157	3	EFO_0008154
Disease	Alzheimer disease	ABI3 ANK3 CYP21A2 WDR81 PEX6 LINGO2 MROH1 PDE7B MTSS2	1.21e-03	485	157	9	MONDO_0004975
Disease	glaucoma (is_implicated_in)	WDR36 LINGO1	1.23e-03	10	157	2	DOID:1686 (is_implicated_in)
Disease	Inherited neuropathies	SPTBN2 ITPR1 SACS	1.26e-03	40	157	3	C0598589
Disease	Combined immunodeficiency	CARMIL2 DOCK8 ADA2	1.36e-03	41	157	3	C0494261
Disease	aseptic loosening, revision of total knee arthroplasty	ANK3 LINGO2 XKR5	1.46e-03	42	157	3	EFO_0010725, EFO_0020972
Disease	PEROXISOME BIOGENESIS DISORDER 1A (ZELLWEGER)	PEX1 PEX6	1.50e-03	11	157	2	C4721541
Disease	phospholipid measurement, high density lipoprotein cholesterol measurement	DNAH10 CYP21A2 PEX6 SNX29 TRIM5 INTS10 HDLBP	1.71e-03	321	157	7	EFO_0004612, EFO_0004639
Disease	Amelogenesis Imperfecta	PEX1 LAMC2	1.79e-03	12	157	2	C0002452
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR2	1.79e-03	12	157	2	DOID:1441 (implicated_via_orthology)
Disease	level of C-X-C motif chemokine 2 in blood serum	OLFML2B TELO2	1.79e-03	12	157	2	OBA_2041207
Disease	hearing impairment	MYO1A ESRRB FANCA DIAPH1	1.89e-03	98	157	4	C1384666
Disease	Adenoid Cystic Carcinoma	DAPK1 FANCA BRD1 CMTR2	2.04e-03	100	157	4	C0010606
Disease	Zellweger Spectrum	PEX1 PEX6	2.11e-03	13	157	2	C3658299
Disease	Zellweger-Like Syndrome	PEX1 PEX6	2.11e-03	13	157	2	C0751594
Disease	Fetal Alcohol Spectrum Disorders	ANK3 BPIFA1	2.11e-03	13	157	2	C2985290
Disease	Infantile Refsum Disease (disorder)	PEX1 PEX6	2.11e-03	13	157	2	C0282527
Disease	gallstones	KDELR3 UBR1 CYP21A2 LRBA	2.69e-03	108	157	4	EFO_0004210
Disease	fibrinogen measurement	CYP21A2 ACAD10 ITPR1 HDLBP	2.78e-03	109	157	4	EFO_0004623
Disease	level of C-X-C motif chemokine 3 in blood serum	OLFML2B TELO2	2.82e-03	15	157	2	OBA_2041208
Disease	Peroxisome biogenesis disorders	PEX1 PEX6	2.82e-03	15	157	2	C1832200
Disease	Adrenoleukodystrophy, Neonatal	PEX1 PEX6	2.82e-03	15	157	2	C0282525
Disease	blood urea nitrogen measurement	CENPN CYP21A2 MYOZ2 DAPK1 ACAD10 FANCA LRBA BCAR3	3.00e-03	452	157	8	EFO_0004741
Disease	Zellweger Syndrome	PEX1 PEX6	3.21e-03	16	157	2	C0043459
Disease	idiopathic scoliosis (implicated_via_orthology)	DNAH10 KIF7	3.21e-03	16	157	2	DOID:0060250 (implicated_via_orthology)
Disease	Fetal Alcohol Syndrome	ANK3 BPIFA1	3.63e-03	17	157	2	C0015923
Disease	peripheral arterial disease, traffic air pollution measurement	TRIM5 ITPR2 AP5Z1 LRBA NSMCE1	3.89e-03	194	157	5	EFO_0004265, EFO_0007908
Disease	matrix metalloproteinase 12 measurement	CASP12 MMP13	4.07e-03	18	157	2	EFO_0010590
Disease	C-X-C motif chemokine 16 measurement	FYCO1 ALOX15	4.07e-03	18	157	2	EFO_0010911
Disease	Bipolar Disorder	ANKK1 ANK3 TRPM2 GPR78 IMPACT ITPR1 STAB1 BRD1	4.14e-03	477	157	8	C0005586
Disease	CCL2 measurement	NCKIPSD FYCO1 ALS2CL GASK1A	4.67e-03	126	157	4	EFO_0004749
Disease	BRCAX breast cancer	ITPR2 PDE7B	5.02e-03	20	157	2	EFO_0009443

Protein segments in the cluster

Peptide	Gene	Start	Entry
AGLAAAALVAMLLEH	TMEM62	11	Q0P6H9
VGSMEDILEELLQHR	ALS2CL	651	Q60I27
LLGELILDRHNFAIM	CAB39L	231	Q9H9S4
TDAMLGEIILALHQL	ARSK	286	Q6UWY0
LVELELHRGSSMEIN	CATSPERZ	91	Q9NTU4
LGMDIHASDLNLLTR	DAPK1	1296	P53355
HLGLEEQLRELLDML	BRD1	711	O95696
GMISEQIAQLAAHLR	COL9A3	531	Q14050
LDIIERHNTMAIGIA	BCAR3	596	O75815
GMTEHQDRALTLLRD	CIITA	586	P33076
LLDDRGMTALSRHLE	CARMIL2	286	Q6F5E8
LAAQEGHAEMVALLL	ANK1	641	P16157
LEIIHLLAESHANMG	ANKK1	606	Q8NFD2
LEALGLTMHELSLVR	APCDD1L	186	Q8NCL9
LGLAGRALHLLAMQA	CFAP46	1956	Q8IYW2
LHSLRELHTGDVMIL	CMTR2	631	Q8IYT2
HDGLVDIMVHLLAVR	DNAH11	1166	Q96DT5
RLLVLRAAHLMDLAG	ACAD10	971	Q6JQN1
LDRLMDGRTVLVIAH	ABCB10	676	Q9NRK6
MLVDGQTHLVLIREE	AGAP2	446	Q99490
LALDGHIQSARALMV	CLDN19	71	Q8N6F1
IMALDIDERHLLRLG	AQR	866	O60306
ALVDAGTALEMLHAL	AP5Z1	456	O43299
HLDLAIELGSRALQM	ADCY10	1311	Q96PN6
GRIDDMLNVSGHLLS	ACSS2	566	Q9NR19
SLALQSHLEELGLLM	NPR1	766	P16066
SELMRLGLHQVLQDL	DIAPH1	336	O60610
LHNRNGSELDLLGMR	CASP12	111	Q6UXS9
NANMGIRIIETLDLH	NBEAL1	486	Q6ZS30
DAQIVHIAMEAGLRI	RC3H2	281	Q9HBD1
SQLHGMDLLVLLDLI	QPCT	236	Q16769
LHSGRDLHNLDLMIG	PTPN3	221	P26045
DHSLRESMIQLAEGL	PTPN4	636	P29074
LLKNMGAHSVVLDLL	ITPR2	1206	Q14571
RDDMALGHVIVLLQQ	INTS10	581	Q9NVR2
ITGMLLEIDNSELLH	PABPC1	581	P11940
HTLRMLDLQGAALRQ	ABI3	71	Q9P2A4
ASLNIRVEEGMHLLI	ABCD1	491	P33897
LGRHMEALEIAANLE	C8orf76	106	Q96K31
LLHTQTKEGMELLAR	RAB3GAP2	1316	Q9H2M9
LLHGTIILDCVNMDL	PRUNE1	171	Q86TP1
MHNLNSALDALRGVL	NEUROG3	96	Q9Y4Z2
HLSNTLLDGEMIIDR	RNGTT	336	O60942
RNMGAHAVVLELLQI	ITPR1	1216	Q14643
IRAVELMLQAGHSDV	MTMR11	286	A4FU01
SRHILQQTLMDEGLR	NAB2	451	Q15742
LIEHNQRGILAMLDE	MYO1A	441	Q9UBC5
RHLGDQMEASLLAVR	FYCO1	671	Q9BQS8
DVQEDALHGLTMLRT	LRRC53	71	A6NM62
QVLERIGETLHEMLS	FSIP2	1431	Q5CZC0
LLEGHVHMAAVDLLI	CYP21A2	276	P08686
VLIEMDGHRALLRTE	PLXNB2	1071	O15031
MNVFRILGDLSHLLA	KDELR3	1	O43731
LNFTRLHDGIADIMI	MMP13	151	P45452
DLAMVLTRGLSLEHQ	MTSS2	446	Q765P7
LGEDARVMAVLRHLL	PEX6	541	Q13608
LDIMLGLLAAAAHDV	PDE7B	201	Q9NP56
IEDLQNDLLSHSGML	MRTFB	1001	Q9ULH7
EVLSLLEMGNAARHT	KIF7	191	Q2M1P5
CLIHSMNGDLLRTLE	LRBA	2721	P50851
ELQSHLLRGHLMAEV	ALOX15	356	P16050
HTLGDNLLDSRMEIR	LAMB1	241	P07942
GMFSDLIRLQELHIV	LINGO2	291	Q7L985
TIEGSMLHELLRLQE	LINGO1	301	Q96FE5
MLHELLRLQEIQLVG	LINGO1	306	Q96FE5
NIVSLLLSMLGHDED	GCN1	2426	Q92616
LGESELRALFHMNIL	NLRP5	556	P59047
LGMIELILLDSCLHT	OR5B12	41	Q96R08
EAMLGLARLVHLVES	MROH1	1426	Q8NDA8
LVMHLGLTSEDQDIL	RALGAPA2	1041	Q2PPJ7
LLSQGSILLEHVAEM	HK3	341	P52790
VNLSLGHLLLAALDM	GPR78	46	Q96P69
LQDNGLTDVMLHALL	HUWE1	576	Q7Z6Z7
ETAAGGRLLHLMEIL	IMPACT	241	Q9P2X3
LAEIVMAIDSVHRLG	DMPK	176	Q09013
LALRVADEMDLTLGH	DQX1	111	Q8TE96
QDLLAGLNLTHALLM	OTOP2	396	Q7RTS6
LHREGAITMALLENL	PRTG	871	Q2VWP7
TGLASARNLEHLEMV	FBXO38	256	Q6PIJ6
MQDLRLEGALHLLLA	RBBP8NL	346	Q8NC74
GMRVQSELEHLSELR	CFAP119	11	A1A4V9
LTDHDVQMLRLLAQG	GASK1A	261	Q9UFP1
LRLEHVGVSLTDDLM	FASTKD5	616	Q7L8L6
TDHSDQLRLSGLEML	HEATR5A	1276	Q86XA9
SNLNRLIMGTHRDLE	BRME1	616	Q0VDD7
RTGLVGMLTHLDDLQ	BSPRY	161	Q5W0U4
LRGLDITLVHDIVNM	BPIFA1	231	Q9NP55
HGNEALGRELMLQLS	CPN1	86	P15169
SGNLATEAHLIILDM	DOCK8	1426	Q8NF50
MDGHRLIHTNGTLLL	DSCAML1	1336	Q8TD84
RLFVMLSAEELVGHL	FANCA	361	O15360
MGSARVAELLLLHGA	CDKN2B	56	P42772
ILDALMLNTTRIGHG	ADA2	371	Q9NZK5
HVDMVSLLLGRNANV	ANK3	676	Q12955
SLGLDINMDSRIIHE	CENPN	226	Q96H22
AIAREHMGQLLHQLL	EIF4G1	1291	Q04637
QDTLNTLDGLLHLMD	LAMC2	1096	Q13753
ALHGMLNAEALAAIL	CPEB1	436	Q9BZB8
IMDEEHSRLAGLLEL	ESRRB	306	O95718
HGMISREAADQLLIV	CHN1	51	P15882
GLVLLEEMLALGNNH	DNER	266	Q8NFT8
HMLIGTLNDAESVLL	DNAH10	716	Q8IVF4
DILLHHIFQERMDLL	SACS	3626	Q9NZJ4
GRAEMLDHAVLLQVI	SLC38A10	691	Q9HBR0
LLGMDLATLEITAHN	RYR1	4741	P21817
LEALHGMLLSSGLQD	PEX1	1056	O43933
AELGNMVSLRELHLN	CNOT6	91	Q9ULM6
RRFLQLLMTHGVLEE	NSMCE1	16	Q8WV22
AAHGVLLQALDEMRA	IRGQ	596	Q8WZA9
NKMIGLESLRELRHL	LRRC8D	576	Q7L1W4
LLLQLGEHIQDTEMI	RTKN	151	Q9BST9
GVRLEDLQHMCLELT	SYTL4	586	Q96C24
MEILTELGLHFRVLD	SARS2	376	Q9NP81
LEQHLGLEALMSSGR	SESN2	61	P58004
LRNLLDGEMEHSAAL	SNX29	491	Q8TEQ0
DLHNLMVDLRGLVHA	CCDC51	261	Q96ER9
GEMAIELHLQFLIRN	PSMD1	331	Q99460
QLVLGRLAHTLGALM	TELO2	721	Q9Y4R8
DIHGAFLIMLERLQS	VPS8	1081	Q8N3P4
MGLVEMLHRSNLLAL	WDR45	51	Q9Y484
VLHMSELLNRGLGVH	SKIV2L	621	Q15477
REHMGNVVEALIALT	HYPK	106	Q9NX55
IEDQLLRHNGLMTSV	OLFML2B	331	Q68BL8
LVANMLSIAGADHII	PRPS1L1	111	P21108
LMELVRRNTGLSHEL	NCKIPSD	316	Q9NZQ3
IHLSDHLMQAGILEL	ABCC8	861	Q09428
LLLEAALGLERAHMG	CLTCL1	1301	P53675
TGMAIDNHLLALREL	CHAT	616	P28329
VQENASHLHGRLMLL	C12orf4	36	Q9NQ89
IILHNTMESLLERGE	YKT6	151	O15498
LVMDLLVLGLHRASE	PRPF8	1046	Q6P2Q9
LISDLEHRLQGSVME	TRIM5	231	Q9C035
LLAAGSHMLREVLDG	TNRC18	1421	O15417
ELHRNMLGLLGNVAE	ZER1	586	Q7Z7L7
HMLLEGLRELQGLQN	UXT	136	Q9UBK9
ALRLLNKHTALRGEM	SPTBN2	676	O15020
DLLHAMVLLKLGQET	TICAM1	41	Q8IUC6
LQMHHVAQVLRELLG	TRPM2	556	O94759
HMNGELVLRKARSLL	TBC1D16	676	Q8TBP0
LQMAFHILALGLLEE	UBR1	911	Q8IWV7
LAAILRGHMIRNVEA	STAB1	1791	Q9NY15
IIASNGLLHILDRAM	STAB2	491	Q8WWQ8
GIMRDIAHLEITALC	TTC14	151	Q96N46
DLLLQHIGTSAIMDL	PPP6R1	151	Q9UPN7
HSRILDIDNVDLAMG	TIMM44	366	O43615
ILLSLRLHLGMSDDE	UBR3	771	Q6ZT12
LEQGLDVLEIMRNIH	WASHC4	776	Q2M389
ISDHTLLRGVLHMLD	TMEM89	116	A2RUT3
EDLIHGDLTTSNMLL	TP53RK	156	Q96S44
LSMLGLLRHILSQEG	SLC25A23	416	Q9BV35
GMLINIHSDHILRNL	SRD5A1	161	P18405
AHGGRMALDALLQEI	ZC3HAV1	16	Q7Z2W4
LDVSAGQLLMVDGRH	PLBD2	66	Q8NHP8
EIMQRTGAHLELSLA	HDLBP	106	Q00341
IRGALEMVHLAADVT	TRAPPC3L	136	Q5T215
LRMDHSQGLELQEVA	WDR31	351	Q8NA23
MHARLLGLSALLQAA	XKR5	1	Q6UX68
LQRVLHLIGMALQEE	UBR2	921	Q8IWV8
ELLLFLMDGLHEDLN	USP8	871	P40818
LLLLEGLQHMLSDQA	ULK1	1011	O75385
LLHRDMQALGVLLAE	WDR81	766	Q562E7
MLLHRDSGILGLALD	WDR36	586	Q8NI36
EHVDALRMTLGLQRL	ZC4H2	106	Q9NQZ6
LVAHLEMIEGDLALQ	VPS13D	1901	Q5THJ4
DIMLEELSHLSNRGA	MYOZ2	41	Q9NPC6