Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainNFAT

NFATC1 NFATC3 NFATC4

1.07e-065903IPR008366
Domain-

ILDR2 TGM3 F11R NFATC1 KALRN NFATC3 NFATC4 PTPRS FSTL5 COL14A1 IL1RL1 PTGFRN CNTFR MYBPC3

3.29e-0666390142.60.40.10
DomainIg-like_fold

ILDR2 TGM3 F11R NFATC1 KALRN NFATC3 NFATC4 PTPRS FSTL5 COL14A1 IL1RL1 PTGFRN CNTFR MYBPC3

6.76e-067069014IPR013783
DomainRHD_dimer

NFATC1 NFATC3 NFATC4

1.27e-0510903IPR032397
DomainRHD_dimer

NFATC1 NFATC3 NFATC4

1.27e-0510903PF16179
DomainREL_1

NFATC1 NFATC3 NFATC4

1.27e-0510903PS01204
Domain-

NFATC1 NFATC3 NFATC4

1.27e-05109032.60.40.340
DomainNFkB/Dor

NFATC1 NFATC3 NFATC4

1.27e-0510903IPR000451
DomainRHD_DNA_bind_dom

NFATC1 NFATC3 NFATC4

1.27e-0510903IPR011539
DomainRHD_DNA_bind

NFATC1 NFATC3 NFATC4

1.27e-0510903PF00554
DomainREL_2

NFATC1 NFATC3 NFATC4

1.27e-0510903PS50254
DomainP25-alpha

TPPP2 TPPP3

6.87e-053902IPR008907
Domainp25-alpha

TPPP2 TPPP3

6.87e-053902PF05517
DomainConA-like_dom

MEP1B NRXN2 TRIML2 COL14A1 HERC1 CLSTN1 RFPL1

9.07e-05219907IPR013320
DomainIGc2

F11R KALRN PTPRS FSTL5 IL1RL1 CNTFR MYBPC3

1.41e-04235907SM00408
DomainIg_sub2

F11R KALRN PTPRS FSTL5 IL1RL1 CNTFR MYBPC3

1.41e-04235907IPR003598
DomainIG

ILDR2 F11R KALRN PTPRS FSTL5 IL1RL1 PTGFRN CNTFR MYBPC3

1.94e-04421909SM00409
DomainIg_sub

ILDR2 F11R KALRN PTPRS FSTL5 IL1RL1 PTGFRN CNTFR MYBPC3

1.94e-04421909IPR003599
DomainIPT

NFATC1 NFATC3 NFATC4

2.91e-0427903SM00429
DomainIg_I-set

F11R KALRN PTPRS FSTL5 IL1RL1 MYBPC3

3.14e-04190906IPR013098
DomainI-set

F11R KALRN PTPRS FSTL5 IL1RL1 MYBPC3

3.14e-04190906PF07679
DomainTIG

NFATC1 NFATC3 NFATC4

4.41e-0431903PF01833
DomainIPT

NFATC1 NFATC3 NFATC4

4.85e-0432903IPR002909
DomainIG_LIKE

ILDR2 F11R KALRN PTPRS FSTL5 IL1RL1 PTGFRN CNTFR MYBPC3

5.97e-04491909PS50835
DomainVillin/Gelsolin

CAPG SVIL

6.31e-048902IPR007122
DomainGEL

CAPG SVIL

6.31e-048902SM00262
DomainIg-like_dom

ILDR2 F11R KALRN PTPRS FSTL5 IL1RL1 PTGFRN CNTFR MYBPC3

7.09e-04503909IPR007110
Domainfn3

KALRN PTPRS COL14A1 CNTFR MYBPC3

1.12e-03162905PF00041
Domain-

SORT1 WDR3 FSTL5 SMU1 HERC1 DCAF5 DYNC1I2

1.13e-033339072.130.10.10
DomainWD40/YVTN_repeat-like_dom

SORT1 WDR3 FSTL5 SMU1 HERC1 DCAF5 DYNC1I2

1.17e-03335907IPR015943
DomainIg_E-set

TGM3 NFATC1 NFATC3 NFATC4

1.61e-03104904IPR014756
DomainFN3

KALRN PTPRS COL14A1 CNTFR MYBPC3

2.01e-03185905SM00060
DomainGelsolin

CAPG SVIL

2.01e-0314902PF00626
DomainGelsolin-like_dom

CAPG SVIL

2.01e-0314902IPR007123
Domainp53-like_TF_DNA-bd

NFATC1 NFATC3 NFATC4

2.13e-0353903IPR008967
Domainig

F11R PTPRS FSTL5 PTGFRN CNTFR

2.26e-03190905PF00047
DomainImmunoglobulin

F11R PTPRS FSTL5 PTGFRN CNTFR

2.26e-03190905IPR013151
DomainFN3

KALRN PTPRS COL14A1 CNTFR MYBPC3

2.76e-03199905PS50853
DomainLH2

LOXHD1 PKD1L2

3.34e-0318902SM00308
DomainFN3_dom

KALRN PTPRS COL14A1 CNTFR MYBPC3

3.41e-03209905IPR003961
Domain-

LOXHD1 PKD1L2

4.54e-03219022.60.60.20
DomainPLAT

LOXHD1 PKD1L2

4.54e-0321902PF01477
DomainPLAT/LH2_dom

LOXHD1 PKD1L2

4.54e-0321902IPR001024
DomainPLAT

LOXHD1 PKD1L2

4.54e-0321902PS50095
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_CN_SIGNALING_PATHWAY

NFATC1 NFATC3 NFATC4

2.19e-0512673M47956
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_CALCINEURIN_SIGNALING_PATHWAY

NFATC1 NFATC3 NFATC4

5.50e-0516673M47449
PathwayKEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAQ_PLCB_G_CALCINEURIN

NFATC1 NFATC3 NFATC4

6.65e-0517673M47560
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_CALCINEURIN_SIGNALING_PATHWAY

NFATC1 NFATC3 NFATC4

7.96e-0518673M47580
PathwayBIOCARTA_CALCINEURIN_PATHWAY

NFATC1 NFATC3 NFATC4

7.96e-0518673MM1385
PathwayBIOCARTA_CALCINEURIN_PATHWAY

NFATC1 NFATC3 NFATC4

7.96e-0518673M3430
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

NFATC1 NFATC3 NFATC4

9.42e-0519673M47543
PathwayWP_FOXA2_PATHWAY

FASN APOB IRS2

1.28e-0421673M42579
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

NFATC1 NFATC3 NFATC4

1.28e-0421673M47542
PathwayWP_CANCER_IMMUNOTHERAPY_BY_PD1_BLOCKADE

NFATC1 NFATC3 NFATC4

1.70e-0423673M39843
PathwayBIOCARTA_GPCR_PATHWAY

NFATC1 NFATC3 NFATC4

3.43e-0429673MM1495
PathwayBIOCARTA_GPCR_PATHWAY

NFATC1 NFATC3 NFATC4

3.80e-0430673M9664
PathwayBIOCARTA_BCR_PATHWAY

NFATC1 NFATC3 NFATC4

4.61e-0432673MM1355
PathwayWP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR

NFATC1 NFATC3 NFATC4

4.61e-0432673M39521
PathwayBIOCARTA_BCR_PATHWAY

NFATC1 NFATC3 NFATC4

5.06e-0433673M9494
PathwayBIOCARTA_FMLP_PATHWAY

NFATC1 NFATC3 NFATC4

5.53e-0434673M10287
PathwayBIOCARTA_FMLP_PATHWAY

NFATC1 NFATC3 NFATC4

5.53e-0434673MM1399
PathwayREACTOME_CALCINEURIN_ACTIVATES_NFAT

NFATC1 NFATC3

7.84e-049672M27106
PathwayBIOCARTA_FCER1_PATHWAY

NFATC1 NFATC3 NFATC4

8.30e-0439673MM1397
PathwayBIOCARTA_FCER1_PATHWAY

NFATC1 NFATC3 NFATC4

8.30e-0439673M1908
PathwayBIOCARTA_TCR_PATHWAY

NFATC1 NFATC3 NFATC4

1.03e-0342673MM1504
PathwayBIOCARTA_TCR_PATHWAY

NFATC1 NFATC3 NFATC4

1.18e-0344673M19784
PathwayREACTOME_CALCINEURIN_ACTIVATES_NFAT

NFATC1 NFATC3

1.19e-0311672MM14810
PathwayREACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION

NFATC1 NFATC3

1.19e-0311672M27466
PathwayWP_HEART_DEVELOPMENT

NFATC1 NFATC3 NFATC4

1.35e-0346673MM15884
PathwayWP_HEART_DEVELOPMENT

NFATC1 NFATC3 NFATC4

1.43e-0347673M39610
PathwayBIOCARTA_NFAT_PATHWAY

NFATC1 NFATC3 NFATC4

1.62e-0349673MM1442
Pubmed

Nuclear factor of activated T cells is activated in the endothelium of retinal microvessels in diabetic mice.

NFATC1 NFATC3 NFATC4

7.63e-08494325918731
Pubmed

NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis.

NFATC1 NFATC3 NFATC4

7.63e-08494326527057
Pubmed

HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cells.

NFATC1 NFATC3 NFATC4

7.63e-08494316260021
Pubmed

Alternative splicing and expression of human and mouse NFAT genes.

NFATC1 NFATC3 NFATC4

7.63e-08494318675896
Pubmed

Transcription factors of the NFAT family: regulation and function.

NFATC1 NFATC3 NFATC4

7.63e-0849439143705
Pubmed

The transcription factor nuclear factor of activated T cells c3 modulates the function of macrophages in sepsis.

NFATC1 NFATC3 NFATC4

7.63e-08494324970700
Pubmed

Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development.

NFATC1 NFATC3 NFATC4

1.90e-07594317693409
Pubmed

Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1.

NFATC1 NFATC3 NFATC4

1.90e-07594322593154
Pubmed

Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif.

NFATC1 NFATC3 NFATC4

1.90e-0759437999066
Pubmed

Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.

NFATC1 NFATC3 NFATC4

1.90e-07594310089876
Pubmed

NFAT: ubiquitous regulator of cell differentiation and adaptation.

NFATC1 NFATC3 NFATC4

1.90e-07594311877454
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

WDR3 TGM3 FASN CAD SERPINB3 USP9X G3BP2 SMU1 APOB PFKL EPB41L3 ANKHD1 ATAD2 DICER1 TOP2A VDAC3 CPSF7

2.50e-071425941730948266
Pubmed

Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells.

NFATC1 NFATC3 NFATC4

3.80e-07694324352425
Pubmed

A strategy for probing the function of noncoding RNAs finds a repressor of NFAT.

NFATC1 NFATC3 NFATC4

3.80e-07694316141075
Pubmed

Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB.

NFATC1 NFATC3 NFATC4

3.80e-07694312788643
Pubmed

Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering.

NFATC1 NFATC3 NFATC4

3.80e-0769438814265
Pubmed

The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins.

NFATC1 NFATC3 NFATC4

3.80e-07694325728138
Pubmed

A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis.

NFATC1 NFATC3 NFATC4

3.80e-07694315339668
Pubmed

Human immunodeficiency virus type 1 Tat increases cooperation between AP-1 and NFAT transcription factors in T cells.

NFATC1 NFATC3 NFATC4

3.80e-07694316690925
Pubmed

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

NFATC1 NFATC3 NFATC4

6.64e-07794316554754
Pubmed

Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts.

NFATC1 NFATC3 NFATC4

6.64e-07794317430895
Pubmed

Extracellular HIV-Tat induces cyclooxygenase-2 in glial cells through activation of nuclear factor of activated T cells.

NFATC1 NFATC3 NFATC4

6.64e-07794318097055
Pubmed

Calcium/NFAT signalling promotes early nephrogenesis.

NFATC1 NFATC3 NFATC4

6.64e-07794321295565
Pubmed

Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth.

NFATC1 NFATC3 NFATC4

1.06e-06894312370307
Pubmed

Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity.

NFATC1 NFATC3 NFATC4

1.06e-0689437957556
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

CEP350 DNAH12 USP9X G3BP2 DDHD1 RAB11FIP5 TMED2 IRS2 XPC CSMD2 ACSS3

1.27e-06638941131182584
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ILDR2 FASN CAD NRXN2 GIT1 KALRN PTPRS USP9X G3BP2 SVIL SMU1 SSH2 PFKL EPB41L3 VDAC3 CPSF7

1.38e-061431941637142655
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

SORT1 KMT2C LOXHD1 GIT1 PTPRS SERPINB3 SERPINB4 USP9X G3BP2 IRS2 HERC1 EPB41L3 POLQ DYNC1I2 VDAC3

1.79e-061284941517353931
Pubmed

Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling.

NFATC1 NFATC3 NFATC4

2.26e-061094319710169
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

WDR3 TGM3 FASN CAD SERPINB3 SERPINB4 SMU1 XPC SNX33 PFKL EPB41L3 ANKHD1 ATAD2 TOP2A DYNC1I2

3.40e-061353941529467282
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

CEP350 WDR3 FASN CAD F11R USP9X SVIL SMU1 PFKL DICER1 TOP2A VDAC3 CPSF7

3.85e-061024941324711643
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

CEP350 WDR3 FASN TCHHL1 G3BP2 SVIL SMU1 COL14A1 APOB XPC SNX33 ANKHD1 DICER1 VDAC3 CPSF7

3.99e-061371941536244648
Pubmed

The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases.

SERPINB3 SERPINB4

7.23e-06294215203214
Pubmed

Increased Th1 immune response in SERPINB3 transgenic mice during acute liver failure.

SERPINB3 SERPINB4

7.23e-06294223354406
Pubmed

High extracellular calcium-induced NFATc3 regulates the expression of receptor activator of NF-κB ligand in osteoblasts.

NFATC1 NFATC3

7.23e-06294221514407
Pubmed

Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.

SORT1 APOB

7.23e-06294222751103
Pubmed

Characterization of novel squamous cell carcinoma antigen-related molecules in mice.

SERPINB3 SERPINB4

7.23e-06294215504361
Pubmed

SCCA2-like serpins mediate genetic predisposition to skin tumors.

SERPINB3 SERPINB4

7.23e-06294212702576
Pubmed

Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.

SERPINB3 SERPINB4

7.23e-06294235022507
Pubmed

SERPINB3/B4 contributes to early inflammation and barrier dysfunction in an experimental murine model of atopic dermatitis.

SERPINB3 SERPINB4

7.23e-06294225111616
Pubmed

Squamous cell carcinoma antigen production in nasal inverted papilloma.

SERPINB3 SERPINB4

7.23e-06294223168150
Pubmed

Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma.

SERPINB3 SERPINB4

7.23e-06294214970861
Pubmed

Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas.

SERPINB3 SERPINB4

7.23e-06294210653592
Pubmed

Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer.

SERPINB3 SERPINB4

7.23e-06294229112685
Pubmed

Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells.

SERPINB3 SERPINB4

7.23e-06294210956412
Pubmed

SerpinB3 as a Pro-Inflammatory Mediator in the Progression of Experimental Non-Alcoholic Fatty Liver Disease.

SERPINB3 SERPINB4

7.23e-06294235874657
Pubmed

Serpin B4 isoform overexpression is associated with aberrant epithelial proliferation and lung cancer in idiopathic pulmonary fibrosis.

SERPINB3 SERPINB4

7.23e-06294222406480
Pubmed

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins.

NFATC3 NFATC4

7.23e-0629427749981
Pubmed

Recurrent SERPINB3 and SERPINB4 mutations in patients who respond to anti-CTLA4 immunotherapy.

SERPINB3 SERPINB4

7.23e-06294227668655
Pubmed

Contribution of ApoB-100/SORT1-Mediated Immune Microenvironment in Regulating Oxidative Stress, Inflammation, and Ferroptosis After Spinal Cord Injury.

SORT1 APOB

7.23e-06294238337131
Pubmed

Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons.

NFATC3 NFATC4

7.23e-06294222977251
Pubmed

Serpinb3 is overexpressed in the liver in presence of iron overload.

SERPINB3 SERPINB4

7.23e-06294228935635
Pubmed

Genetic or pharmacologic disruption of the calcineurin-nuclear factor of activated T-cells axis prevents social stress-induced voiding dysfunction in a murine model.

NFATC3 NFATC4

7.23e-06294224909609
Pubmed

Overexpression of SERPIN B3 promotes epithelial proliferation and lung fibrosis in mice.

SERPINB3 SERPINB4

7.23e-06294221403642
Pubmed

Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter.

SERPINB3 SERPINB4

7.23e-06294211267667
Pubmed

Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours.

SERPINB3 SERPINB4

7.23e-06294229491058
Pubmed

Distinct roles of NFATc1 and NFATc4 in human primary myoblast differentiation and in the maintenance of reserve cells.

NFATC1 NFATC4

7.23e-06294228760926
Pubmed

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases.

SERPINB3 SERPINB4

7.23e-06294211863458
Pubmed

IgM-linked SerpinB3 and SerpinB4 in sera of patients with chronic liver disease.

SERPINB3 SERPINB4

7.23e-06294222808225
Pubmed

Tumor-related protein, the squamous cell carcinoma antigen binds to the intracellular protein carbonyl reductase.

SERPINB3 SERPINB4

7.23e-06294220428762
Pubmed

The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease.

SERPINB3 SERPINB4 PTGFRN

8.50e-061594330704515
Pubmed

Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.

NFATC1 NFATC3 NFATC4

8.50e-061594321047202
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

KMT2C FASN HIVEP2 NFATC1 KALRN KIF26A PTPRS PIEZO1 IRS2 DTX2 HERC1 ANKHD1 CYTH4

8.72e-061105941335748872
Pubmed

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

TGM3 SERPINB3 SERPINB4 SVIL SMU1 TMED2 APOB ATAD2 TOP2A VDAC3

1.10e-05652941031180492
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

WDR3 TGM3 FASN CAD USP9X SMU1 EPB41L3 ANKHD1 ATAD2 DICER1

1.12e-05653941022586326
Pubmed

Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.

SORT1 RNF213 APOB

1.80e-051994323118302
Pubmed

The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53.

FASN CAD G3BP2 SMU1

2.03e-055994432382008
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CEP350 HIVEP2 GIT1 NFATC3 SLF2 SVIL RAB11FIP5 IRS2 SSH2 PATJ EPB41L3

2.14e-05861941136931259
Pubmed

NFAT transcription factors are essential and redundant actors for leukemia initiating potential in T-cell acute lymphoblastic leukemia.

NFATC1 NFATC3

2.16e-05394234234374
Pubmed

HIV-1 infection increases microRNAs that inhibit Dicer1, HRB and HIV-EP2, thereby reducing viral replication.

HIVEP2 DICER1

2.16e-05394230682089
Pubmed

NFATc3 and NFATc4 are required for cardiac development and mitochondrial function.

NFATC3 NFATC4

2.16e-05394212750314
Pubmed

Anti-apoptotic effects of SERPIN B3 and B4 via STAT6 activation in macrophages after infection with Toxoplasma gondii.

SERPINB3 SERPINB4

2.16e-05394222451727
Pubmed

Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II.

SORT1 APOB

2.16e-05394227112212
Pubmed

Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines.

NFATC1 NFATC3

2.16e-05394217082579
Pubmed

Dispensable role of protein 4.1B/DAL-1 in rodent adrenal medulla regarding generation of pheochromocytoma and plasmalemmal localization of TSLC1.

RET EPB41L3

2.16e-05394219321127
Pubmed

Increased expression of NF-AT3 and NF-AT4 in the atria correlates with procollagen I carboxyl terminal peptide and TGF-β1 levels in serum of patients with atrial fibrillation.

NFATC3 NFATC4

2.16e-05394225422138
Pubmed

Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions.

TPPP2 TPPP3

2.16e-05394217105200
Pubmed

Molecular cloning and functional characterization of murine cDNA encoding transcription factor NFATc.

NFATC1 NFATC3

2.16e-0539429388475
Pubmed

Diagnostic and prognostic role of SCCA-IgM serum levels in hepatocellular carcinoma (HCC).

SERPINB3 SERPINB4

2.16e-05394224635038
Pubmed

Heparin enhances serpin inhibition of the cysteine protease cathepsin L.

SERPINB3 SERPINB4

2.16e-05394219959474
Pubmed

DNA topoisomerases participate in fragility of the oncogene RET.

RET TOP2A

2.16e-05394224040417
Pubmed

Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells.

SERPINB3 SERPINB4

2.16e-05394219070595
Pubmed

A/ASP/VAL allele combination of IGF1R, IRS2, and UCP2 genes is associated with better metabolic profile, preserved energy expenditure parameters, and low mortality rate in longevity.

UCP2 IRS2

2.16e-05394221340542
Pubmed

NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity.

NFATC1 NFATC3

2.16e-0539427650004
Pubmed

A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases.

SERPINB3 SERPINB4

2.16e-0539429828132
Pubmed

A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene.

SERPINB3 SERPINB4

2.16e-0539427724531
Pubmed

Differentially expressed proteins in human breast cancer cells sensitive and resistant to paclitaxel.

SERPINB3 SERPINB4

2.16e-05394224898082
Pubmed

A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma.

SERPINB3 SERPINB4

2.16e-05394221126757
Pubmed

Uteroglobin suppresses SCCA gene expression associated with allergic asthma.

SERPINB3 SERPINB4

2.16e-05394215677460
Pubmed

The transcription factor NFAT4 is involved in the generation and survival of T cells.

NFATC1 NFATC3

2.16e-0539429768749
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

CAD PTPRS USP9X SVIL SMU1 RAB11FIP5 EPB41L3

2.34e-0531394738270169
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

CAD NFATC1 GIT1 NFATC3 SLF2 USP9X RAB11FIP5 PATJ CPSF7

3.15e-0558894938580884
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

WDR3 TGM3 FASN CAD SERPINB3 G3BP2 SVIL SMU1 PFKL PATJ TOP2A VDAC3 CPSF7

3.36e-051257941336526897
Pubmed

Sequential involvement of NFAT and Egr transcription factors in FasL regulation.

NFATC1 NFATC3

4.32e-05494210755616
Pubmed

Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT.

NFATC3 NFATC4

4.32e-0549429660947
Pubmed

p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies.

TPPP2 TPPP3

4.32e-05494215590652
Pubmed

Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase.

SERPINB3 SERPINB4

4.32e-05494216549498
Pubmed

Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury.

SERPINB3 SERPINB4

4.32e-05494221576355
Pubmed

Calcineurin regulates innate antifungal immunity in neutrophils.

NFATC1 NFATC3

4.32e-05494220421389
Pubmed

Defective T cell development and function in calcineurin A beta -deficient mice.

NFATC1 NFATC3

4.32e-05494212091710
Cytoband18q21.3

SERPINB3 SERPINB4

2.25e-041194218q21.3
GeneFamilyNuclear factors of activated T-cells

NFATC1 NFATC3 NFATC4

6.28e-075733665
GeneFamilyTubulin polymerization promoting proteins

TPPP2 TPPP3

4.81e-0537321240
GeneFamilyGelsolin/villins

CAPG SVIL

4.43e-048732950
GeneFamilyFibronectin type III domain containing

KALRN PTPRS COL14A1 CNTFR MYBPC3

4.72e-04160735555
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

KALRN PTPRS FSTL5 IL1RL1 MYBPC3

4.85e-04161735593
GeneFamilyCadherin related

RET CLSTN1

2.10e-031773224
GeneFamilyWD repeat domain containing

WDR3 SMU1 HERC1 DCAF5 DYNC1I2

4.14e-03262735362
ToppCell(05)_Secretory-(1)_GFP|(05)_Secretory / shred by cell type by condition

FASN SERPINB3 SERPINB4 TMED2 DTX2

2.30e-06100945838340a2b7c76f603e0ef2fe4fd170bd0dbce685
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Stem_cells|GW19 / Sample Type, Dataset, Time_group, and Cell type.

ILDR2 CAPG UCP2 POLQ ATAD2 TOP2A

4.21e-0620094631dd81df9aa754a1e69b905bf9b8ce73ff8175aa
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Stem_cells-Neuroepithelial_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

ILDR2 CAPG UCP2 POLQ ATAD2 TOP2A

4.21e-0620094654174a485a82480726fa06efa6e050ddea77cb3c
ToppCellfacs-Marrow-B-cells-24m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 TPPP2 PTPRS TCHHL1 CYTH4

1.51e-051479459d7e965fe61bd7b31e09c4b2129a5a98c36f4811
ToppCellfacs-Marrow-B-cells-24m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 TPPP2 PTPRS TCHHL1 CYTH4

1.51e-0514794538552953ff65a0fc20bee6ef57dc5885306ad18b
ToppCellfacs-Liver-Hepatocytes-24m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDHD1 CAPG EPB41L3 TMC3 MYBPC3

2.71e-0516694503a47b8687f54955e84df1edcb230db332c4ca8f
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9|TCGA-Bladder / Sample_Type by Project: Shred V9

SERPINB3 SERPINB4 SNX33 CLSTN1 PTGFRN

3.12e-05171945adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCell356C-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

IFTAP KALRN CAPG IL1RL1 TPPP3

3.30e-05173945090dc3c5bd2652a65c2490fc889da858c3af368f
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SORT1 FSTL5 CAPG SVIL MYBPC3

3.78e-051789450b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell15-Trachea-Epithelial-Multiciliated_precursor|Trachea / Age, Tissue, Lineage and Cell class

CEP350 DNAH12 BTG3 TPPP3 TOP2A

4.54e-051859459a8b8360d99375b726ca8e3c9a3f9b08919892d7
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

KMT2C USP9X DDHD1 RNF213 HERC1

4.91e-05188945ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellfacs-Pancreas-Endocrine-3m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP9X UCP2 BTG3 IRS2 EPB41L3

5.29e-05191945b3de0393d6510543533cd851e47a0f95739a0e4e
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MSLNL CAPG UCP2 RNF213 APOB

5.42e-05192945935a4a36881a9fa4daa02cba96af07f6686ed8d6
ToppCellfacs-Aorta-Heart-3m-Mesenchymal|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ILDR2 PTPRS COL14A1 IRS2 PTGFRN

5.42e-051929450dc1f46e40346ed0b286e53b106a812441575100
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2C USP9X RET HERC1 EPB41L3

5.83e-051959453e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2C USP9X RET HERC1 EPB41L3

5.83e-051959457796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW13-Stem_cells|GW13 / Sample Type, Dataset, Time_group, and Cell type.

SLF2 SVIL ANKHD1 ATAD2 TOP2A

6.42e-05199945fd1d1b95e01719e3d0a17d9d1f29717a47209d32
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW13-Stem_cells-Stem_cells|GW13 / Sample Type, Dataset, Time_group, and Cell type.

SLF2 SVIL ANKHD1 ATAD2 TOP2A

6.42e-0519994591882af9dc7265c9b419f4415cbcf656087a2ab3
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

NFATC4 FSTL5 EPB41L3 ATAD2 TOP2A

6.58e-052009457c495030e6566b81d97b5516d1972e335ce5ed8c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FSTL5 CCDC190 PKD1L2 TMC3 CNTFR

6.58e-052009457a8160e6477708f22e48c609bf8f43f3715dcb03
ToppCellcritical-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CEP350 COA1 BTG3 ATAD2 TOP2A

6.58e-05200945f39db4250ce220a3eb58edee3f7fc3671701d46f
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Stem_cells|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CAPG UCP2 BTG3 ATAD2 TOP2A

6.58e-05200945b71138729d2a81cc2f30e3bc15853516a525a17f
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Stem_cells|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CAPG UCP2 BTG3 ATAD2 TOP2A

6.58e-05200945008f137920cc3b599376706803c111d1d0ec17ef
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW12-Stem_cells|GW12 / Sample Type, Dataset, Time_group, and Cell type.

CAPG UCP2 BTG3 ATAD2 TOP2A

6.58e-052009454a57d6ba1531ce4e263daccd5de487977e6a1fdd
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW12-Stem_cells-Stem_cells|GW12 / Sample Type, Dataset, Time_group, and Cell type.

CAPG UCP2 BTG3 ATAD2 TOP2A

6.58e-05200945b706526b9c3485889a31253a1ffd017ad3f3fddc
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Stem_cells-Stem_cells|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CAPG UCP2 BTG3 ATAD2 TOP2A

6.58e-052009458f3067b52865a0f5488e4df0d5a4fea80135cef5
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Stem_cells-Neuroepithelial_cell|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CAPG UCP2 BTG3 ATAD2 TOP2A

6.58e-052009450e119c2742f2be19fde8890d1227bf277ead976f
DrugNSC92228

NFATC1 NFATC3 NFATC4

6.60e-083933CID000017897
Diseasemean platelet volume

CCDC117 HIVEP2 NFATC1 KALRN DDHD1 UCP2 SVIL CELA1 IRS2 CERT1 DCAF5 MYBPC3

8.66e-0510209312EFO_0004584
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

KMT2C COL14A1 EPB41L3

3.91e-0445933DOID:3748 (is_implicated_in)
Diseasenon-alcoholic fatty liver disease (biomarker_via_orthology)

FASN UCP2 IRS2

1.15e-0365933DOID:0080208 (biomarker_via_orthology)
Diseasethyroid peroxidase antibody measurement

KALRN CSMD2 DICER1

1.54e-0372933EFO_0005666
DiseaseColorectal Carcinoma

KMT2C CAD NFATC1 KALRN PTPRS FSTL5 APOB RET

1.70e-03702938C0009402
Diseaseshort-term memory

DNAH12 NFATC1 FSTL5

2.32e-0383933EFO_0004335
DiseaseHypertrophic obstructive cardiomyopathy

FASN MYBPC3

2.81e-0325932C4551472
DiseaseIntellectual Disability

KMT2C FASN HIVEP2 NRXN2 CERT1 DYNC1I2

2.94e-03447936C3714756

Protein segments in the cluster

PeptideGeneStartEntry
HAYTDTGKASGNLET

VDAC3

46

Q9Y277
YTGESQAKHVAAGTA

CCDC117

231

Q8IWD4
SVSAAGFHLEYKTVG

CSMD2

1891

Q7Z408
KLSRHGSGADSDYEN

GIT1

586

Q9Y2X7
AGDGSSVKEVETYHR

ATAD2

56

Q6PL18
VEGKHESYRISATSA

CYTH4

346

Q9UIA0
ETSHIGKGCDRDTYS

CLSTN1

306

O94985
SAVRTHSDLKVGEYS

DICER1

111

Q9UPY3
GVDTGKQSISYDLHT

DICER1

1536

Q9UPY3
GREKYSTSVVEKTHG

RAB11FIP5

51

Q9BXF6
HGIEAKSYSVGASGS

CPSF7

401

Q8N684
AIEQHKTESGYGSES

CERT1

111

Q9Y5P4
KTESGYGSESSLRRH

CERT1

116

Q9Y5P4
AEKRGSYGSTAHASE

ANO7

76

Q6IWH7
RALSSYVSVHAESGK

PCDHA11

501

Q9Y5I1
GLSGYKDSSHGIAES

KMT2C

4176

Q8NEZ4
TASGYSDVTDSKAIG

DTX2

421

Q86UW9
VSAGYRHSAAVTEDG

HERC1

516

Q15751
YHISLKTGDVSGAST

LOXHD1

686

Q8IVV2
KTGDVSGASTDSRVY

LOXHD1

691

Q8IVV2
KYHVASRTALSVGGA

B4GALT7

291

Q9UBV7
SEEGSVYTACRHGSK

DYNC1I2

451

Q13409
IFGHGESSSSRAGKE

CCDC190

276

Q86UF4
AEGKISETTARTYSH

PFKL

141

P17858
DAYSHSSSENGGKSE

KALRN

1726

O60229
HYETEGSRGAVKASA

NFATC1

441

O95644
SDGKYHVVRFTRSGG

NRXN2

1221

Q9P2S2
LHAGVSERSGYTDSE

DCAF5

446

Q96JK2
YKTSERKGTLSTTGH

DNAH12

3046

Q6ZR08
ASLERYEGLAHSSSK

KIF26A

1436

Q9ULI4
YTKAHETFGSSGTLA

MSLNL

476

Q96KJ4
GKYSVHGVTSFVSSR

CELA1

216

Q9UNI1
YSGKSEVGLVSEHFS

PGAP6

36

Q9HCN3
ILGTASHSVDYRKSA

FOXRED2

381

Q8IWF2
VYTGHRRGAATSSKV

PKD1L2

1396

Q7Z442
GDDGSLYITKVTTTH

FSTL5

301

Q8N475
SEDRYTASGVHKGAT

PTPRS

886

Q13332
DYGDIEIGSHRSSSS

IRS2

631

Q9Y4H2
DYESKSDHRSVGGRS

ARHGAP24

606

Q8N264
GSGETTYDHKNTFTL

APOB

1406

P04114
NYKSSTDGASRVEHF

IL1RL1

386

Q01638
EDHVSKRGVFGTDSS

IFTAP

46

Q86VG3
YAHTASEGLRGTETT

COL14A1

426

Q05707
RNSSYVHGGVDASGK

G3BP2

36

Q9UN86
QSTEASDGTEGKVYH

POLQ

596

O75417
AGSEHSGRYRASVES

POLQ

2036

O75417
DGTAHTITDAYAGKE

CNTFR

261

P26992
FEHGTTSGKRVVYVD

FAIM

21

Q9NVQ4
ESSGYKNHDRRSSSG

CEP350

1531

Q5VT06
GTDGIGYSTAKHLAR

DHRSX

51

Q8N5I4
DGYGTHVKSSCSREI

ITLN2

301

Q8WWU7
YQEGGVESAFHKTST

CAPG

116

P40121
ASSSGTRLHRGYVEE

DDHD1

381

Q8NEL9
SFEYIEAHGTGTKVG

FASN

286

P49327
GYGTSAFITHERLKS

MEP1B

556

Q16820
SKSEGLLYVHSSRGG

COA1

96

Q9GZY4
RRVVHASGDASYSAG

EPB41L3

861

Q9Y2J2
YSRGHFDRTKKGTSS

F11R

261

Q9Y624
HSGDVRLDTVGSDAY

PTGFRN

216

Q9P2B2
LGSTARERAKHSGDY

USP9X

1361

Q93008
AEGGSHVYTFRSVSA

RFPL1

261

O75677
DRHLYTTTGGETDFT

SORT1

391

Q99523
VAHFDSGSSKSGRIE

TMC3

771

Q7Z5M5
TRSKYCTETSGVHGD

SVIL

71

O95425
TTHYFKVEDGGERSV

TMEM161B

156

Q8NDZ6
AHYETEGSRGAVKAA

NFATC4

431

Q14934
SAISHTGRTYEAIGE

SNX33

441

Q8WV41
SKGLRSQSSDYTGHV

SLF2

646

Q8IX21
AAHTSAGKTVVAEYA

SKIV2L

331

Q15477
FKAESGRSHGESQET

FAM13C

96

Q8NE31
TTGKAATYHVDRSGN

SERPINB3

66

P29508
SHTIGRYISTKAVGS

TGM3

416

Q08188
VTRALDKVTSDYHSG

BTG3

131

Q14201
SGSGSEYKTHFAASV

ACSS3

56

Q9H6R3
SRDTALTIAADKGHY

ANKHD1

1291

Q8IWZ3
AVDRLTDTSKYTGTH

TPPP2

116

P59282
YSSIRGFLSKHSSDG

RNF213

4806

Q63HN8
YHGSADAKGSTARAS

TRIML2

321

Q8N7C3
AYVTEDGKNTSHRAS

nan

76

Q6ZQY7
FYTKGSEHASIGSRL

UCP2

106

P55851
GHYIISASSDGTVKI

SMU1

361

Q2TAY7
KYSGSEAGSLSHSEQ

SSH2

936

Q76I76
DSTGGSHSVRKGYRI

ILDR2

286

Q71H61
TSHTGEASGIYVKSI

PATJ

386

Q8NI35
AKSESGEGEITTIYH

TTC41P

1246

Q6P2S7
HYETEGSRGAVKAST

NFATC3

446

Q12968
TTEKAATYHVDRSGN

SERPINB4

66

P48594
KGEVSDGYSVSRSNT

TRBV10-1

76

A0A0K0K1A3
LGTADFYTEHGVKVT

CAD

1346

P27708
ATAFHLKGRAGYTTV

RET

741

P07949
TDTSRYTGSHKERFD

TPPP3

126

Q9BW30
KGDRESSGKYTFAAH

TMED2

71

Q15363
SIATSKGGRHVDYVA

TOP2A

316

P11388
LSTGYHTRSGSEEAV

PIEZO1

1611

Q92508
HKYASEDSNGATLTG

TCHHL1

16

Q5QJ38
SGDYVVSSSHDKSLR

WDR3

686

Q9UNX4
SRVSYKEESGSDEAG

XPC

426

Q01831
HSKGSTDSGYFSRSE

HIVEP2

391

P31629
HIGEKSYRSNAKGTS

ZNF776

136

Q68DI1
ASNKYGLATEGTRHT

MYBPC3

51

Q14896