Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ORANGE	HEYL HEY1	1.93e-04	9	44	2	SM00511
Domain	Adenylat/UMP-CMP_kin	AK9 SPEF2	2.41e-04	10	44	2	IPR000850
Domain	AdipoR/HlyIII-related	PAQR5 ADIPOR2	2.94e-04	11	44	2	IPR004254
Domain	HlyIII	PAQR5 ADIPOR2	2.94e-04	11	44	2	PF03006
Domain	Hairy_orange	HEYL HEY1	3.53e-04	12	44	2	PF07527
Domain	Orange_dom	HEYL HEY1	3.53e-04	12	44	2	IPR003650
Domain	ORANGE	HEYL HEY1	4.16e-04	13	44	2	PS51054
Domain	PDEase	PDE6A PDE8B	9.04e-04	19	44	2	IPR023088
Domain	PDEase_I	PDE6A PDE8B	1.11e-03	21	44	2	PF00233
Domain	PDEASE_I	PDE6A PDE8B	1.11e-03	21	44	2	PS00126
Domain	PDEase_CS	PDE6A PDE8B	1.11e-03	21	44	2	IPR023174
Domain	-	PDE6A PDE8B	1.22e-03	22	44	2	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE6A PDE8B	1.33e-03	23	44	2	IPR002073
Domain	HDc	PDE6A PDE8B	1.45e-03	24	44	2	SM00471
Domain	HD/PDEase_dom	PDE6A PDE8B	1.45e-03	24	44	2	IPR003607
Domain	DH_1	ARHGEF28 ARHGEF1	9.67e-03	63	44	2	PS00741
Domain	Ser/Thr_kinase_AS	SIK3 CLK1 CLK3 BUB1	9.76e-03	357	44	4	IPR008271
Domain	S_TKc	SIK3 CLK1 CLK3 BUB1	9.95e-03	359	44	4	SM00220
Domain	PROTEIN_KINASE_ST	SIK3 CLK1 CLK3 BUB1	1.02e-02	362	44	4	PS00108
Domain	RhoGEF	ARHGEF28 ARHGEF1	1.12e-02	68	44	2	SM00325
Domain	DH_2	ARHGEF28 ARHGEF1	1.18e-02	70	44	2	PS50010
Domain	RhoGEF	ARHGEF28 ARHGEF1	1.18e-02	70	44	2	PF00621
Domain	Protein_kinase_ATP_BS	SIK3 CLK1 CLK3 BUB1	1.20e-02	379	44	4	IPR017441
Domain	DH-domain	ARHGEF28 ARHGEF1	1.22e-02	71	44	2	IPR000219
Domain	-	ARHGEF28 ARHGEF1	1.22e-02	71	44	2	1.20.900.10
Domain	Pkinase	SIK3 CLK1 CLK3 BUB1	1.22e-02	381	44	4	PF00069
Pubmed	Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.	LAMA2 HEYL HEY1	3.32e-07	11	45	3	21989910
Pubmed	Impaired fetal muscle development and JAK-STAT activation mark disease onset and progression in a mouse model for merosin-deficient congenital muscular dystrophy.	LAMA2 HEYL HEY1	3.06e-06	22	45	3	28334989
Pubmed	HES and HERP families: multiple effectors of the Notch signaling pathway.	HEYL HEY1	4.91e-06	3	45	2	12548545
Pubmed	Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis.	HEYL HEY1	4.91e-06	3	45	2	10415358
Pubmed	Hesr, a mediator of the Notch signaling, functions in heart and vessel development.	HEYL HEY1	4.91e-06	3	45	2	16165016
Pubmed	Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats.	HEYL HEY1	9.81e-06	4	45	2	21290414
Pubmed	Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites.	HEYL HEY1	9.81e-06	4	45	2	30745427
Pubmed	Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.	CLK1 CLK3	9.81e-06	4	45	2	7990150
Pubmed	Chromosomal mapping of three human LAMMER protein-kinase-encoding genes.	CLK1 CLK3	9.81e-06	4	45	2	9856501
Pubmed	Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism.	HEYL HEY1	9.81e-06	4	45	2	15485867
Pubmed	Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family.	HEYL HEY1	9.81e-06	4	45	2	10860664
Pubmed	Characterization and comparison of four serine- and arginine-rich (SR) protein kinases.	CLK1 CLK3	9.81e-06	4	45	2	9307018
Pubmed	Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.	HEYL HEY1	9.81e-06	4	45	2	31545169
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TSC2 C2CD3 SIK3 ARHGEF28 VIRMA CLK3 ARHGEF1 SPICE1	1.31e-05	861	45	8	36931259
Pubmed	Sox9 Inhibits Cochlear Hair Cell Fate by Upregulating Hey1 and HeyL Antagonists of Atoh1.	HEYL HEY1	1.63e-05	5	45	2	37681879
Pubmed	The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina.	HEYL HEY1	1.63e-05	5	45	2	11160397
Pubmed	Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors.	HEYL HEY1	1.63e-05	5	45	2	21454491
Pubmed	Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.	HEYL HEY1	1.63e-05	5	45	2	11095750
Pubmed	HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.	HEYL HEY1	1.63e-05	5	45	2	10588864
Pubmed	Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.	CLK1 CLK3	1.63e-05	5	45	2	19168442
Pubmed	Identification of a novel interaction of 14-3-3 with p190RhoGEF.	TSC2 ARHGEF28	2.45e-05	6	45	2	11533041
Pubmed	HeyL promotes neuronal differentiation of neural progenitor cells.	HEYL HEY1	2.45e-05	6	45	2	21259317
Pubmed	Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes.	HEYL HEY1	3.42e-05	7	45	2	10964718
Pubmed	Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts.	HEYL HEY1	3.42e-05	7	45	2	16199874
Pubmed	The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function.	HEYL HEY1	3.42e-05	7	45	2	10924525
Pubmed	Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus.	HEYL HEY1	3.42e-05	7	45	2	26068074
Pubmed	SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients.	HEYL HEY1	5.86e-05	9	45	2	34099102
Pubmed	Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea.	HEYL HEY1	7.32e-05	10	45	2	18291358
Pubmed	Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2.	HEYL HEY1	7.32e-05	10	45	2	25733872
Pubmed	Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer.	HEYL HEY1	8.94e-05	11	45	2	17611704
Pubmed	PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif.	PAQR5 ADIPOR2	8.94e-05	11	45	2	16044242
Pubmed	HeyL regulates the number of TrkC neurons in dorsal root ganglia.	HEYL HEY1	8.94e-05	11	45	2	19631204
Pubmed	Perivascular cells support folliculogenesis in the developing ovary.	HEYL HEY1	1.07e-04	12	45	2	36194632
Pubmed	Myocardial Notch1-Rbpj deletion does not affect NOTCH signaling, heart development or function.	HEYL HEY1	1.07e-04	12	45	2	30596653
Pubmed	HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development.	HEYL HEY1	1.27e-04	13	45	2	27160681
Pubmed	Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.	HEYL HEY1	1.70e-04	15	45	2	12971992
Pubmed	Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.	HEYL HEY1	1.70e-04	15	45	2	17194759
Pubmed	LKB1 and Notch Pathways Interact and Control Biliary Morphogenesis.	HEYL HEY1	1.70e-04	15	45	2	26689699
Pubmed	Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis.	HEYL HEY1	1.70e-04	15	45	2	24755984
Pubmed	Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.	HEYL HEY1	1.70e-04	15	45	2	14672936
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	OGFOD1 SIK3 SGMS1 VIRMA CLK1 MYSM1 ARHGEF1 TUFT1	1.72e-04	1242	45	8	30973865
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	OGFOD1 BAZ2A VIRMA ACOT11 RHOBTB2	1.78e-04	407	45	5	12693553
Pubmed	Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac.	HEYL HEY1	1.94e-04	16	45	2	21352545
Pubmed	Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.	HEYL HEY1	1.94e-04	16	45	2	22069191
Pubmed	Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.	HEYL HEY1	1.94e-04	16	45	2	21300049
Pubmed	An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.	HEYL HEY1	1.94e-04	16	45	2	17273555
Pubmed	Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development.	HEYL HEY1	2.20e-04	17	45	2	19161597
Pubmed	Persistent expression of activated Notch inhibits corticotrope and melanotrope differentiation and results in dysfunction of the HPA axis.	HEYL HEY1	2.20e-04	17	45	2	21781958
Pubmed	Segmental expression of Notch and Hairy genes in nephrogenesis.	HEYL HEY1	2.20e-04	17	45	2	15821257
Pubmed	Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1.	HEYL HEY1	2.20e-04	17	45	2	22457635
Pubmed	RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche.	HEYL HEY1	2.20e-04	17	45	2	25406395
Pubmed	Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors.	HEYL HEY1	2.20e-04	17	45	2	22615585
Pubmed	PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.	LAMA2 TUFT1	2.76e-04	19	45	2	21285247
Pubmed	RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.	HEYL HEY1	2.76e-04	19	45	2	20335360
Pubmed	Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves.	HEYL HEY1	2.76e-04	19	45	2	25691540
Pubmed	Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas.	HEYL HEY1	3.06e-04	20	45	2	19501159
Pubmed	Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy.	HEYL HEY1	3.06e-04	20	45	2	23314057
Pubmed	Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition.	HEYL HEY1	3.38e-04	21	45	2	17303760
Pubmed	Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear.	HEYL HEY1	3.38e-04	21	45	2	24583262
Pubmed	Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice.	HEYL HEY1	3.38e-04	21	45	2	23526992
Pubmed	Sequential Notch activation regulates ventricular chamber development.	HEYL HEY1	3.72e-04	22	45	2	26641715
Pubmed	Notch signalling regulates epibranchial placode patterning and segregation.	HEYL HEY1	4.07e-04	23	45	2	31988190
Pubmed	Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation.	HEYL HEY1	4.07e-04	23	45	2	18297083
Pubmed	Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade.	HEYL HEY1	4.07e-04	23	45	2	31789590
Pubmed	Overview of PDEs and their regulation.	PDE6A PDE8B	4.82e-04	25	45	2	17307970
Pubmed	Bmp2 and Notch cooperate to pattern the embryonic endocardium.	HEYL HEY1	5.22e-04	26	45	2	29853617
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	HEYL HEY1	5.22e-04	26	45	2	34189436
Pubmed	The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs.	HEYL HEY1	5.22e-04	26	45	2	24391519
Pubmed	Notch signaling controls liver development by regulating biliary differentiation.	HEYL HEY1	5.22e-04	26	45	2	19369401
Pubmed	Numb deletion in POMC-expressing cells impairs pituitary intermediate lobe cell adhesion, progenitor cell localization, and neuro-intermediate lobe boundary formation.	HEYL HEY1	5.63e-04	27	45	2	21084383
Pubmed	NOTCH activity differentially affects alternative cell fate acquisition and maintenance.	HEYL HEY1	6.50e-04	29	45	2	29578405
Pubmed	Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.	HEYL HEY1	6.96e-04	30	45	2	20890042
Pubmed	STK11 is required for the normal program of ciliated cell differentiation in airways.	SIK3 HEY1	7.43e-04	31	45	2	31636950
Pubmed	Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice.	HEYL HEY1	7.43e-04	31	45	2	19666558
Pubmed	Wnt/β-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells.	HEYL HEY1	7.43e-04	31	45	2	22711842
Pubmed	Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction.	HEYL HEY1	7.92e-04	32	45	2	31434798
Pubmed	Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.	HEYL HEY1	8.43e-04	33	45	2	16000382
Pubmed	Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.	HEYL HEY1	8.94e-04	34	45	2	21311046
Pubmed	Notch signaling regulates smooth muscle differentiation of epicardium-derived cells.	HEYL HEY1	9.48e-04	35	45	2	21252157
Pubmed	A Y2H-seq approach defines the human protein methyltransferase interactome.	CLK1 CLK3 ZUP1 SPICE1	9.96e-04	342	45	4	23455924
Pubmed	Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors.	HEYL HEY1	1.00e-03	36	45	2	25715395
Pubmed	Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification.	HEYL HEY1	1.06e-03	37	45	2	24673559
Pubmed	Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis.	HEYL HEY1	1.12e-03	38	45	2	22783020
Cytoband	8q22.1	INTS8 VIRMA	7.16e-04	40	45	2	8q22.1
Cytoband	11q13.4	RNF121 C2CD3	2.49e-03	75	45	2	11q13.4
GeneFamily	CDC like kinases	CLK1 CLK3	1.29e-05	4	27	2	480
GeneFamily	Progestin and adipoQ receptor family	PAQR5 ADIPOR2	1.17e-04	11	27	2	930
GeneFamily	Phosphodiesterases	PDE6A PDE8B	5.81e-04	24	27	2	681
GeneFamily	Basic helix-loop-helix proteins	HEYL HEY1	1.17e-02	110	27	2	420
Coexpression	GSE3920_UNTREATED_VS_IFNG_TREATED_FIBROBLAST_DN	SGMS1 CLK1 DISP1 SPEF2 TUFT1	1.38e-05	179	45	5	M6689
ToppCell	normal_Lung-Fibroblasts-Pericytes\|Fibroblasts / Location, Cell class and cell subclass	HEYL PDE8B DISP1 ZUP1	2.60e-05	170	45	4	d69c0ea4cb6b204f19d0a5d2164afb42184779ac
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAQR5 ASTN2 FBXO31 ZUP1	3.11e-05	178	45	4	c87945146b2734141f07b39d268e0d8086ee0364
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAQR5 GCH1 MCUB DISP1	3.25e-05	180	45	4	9c47852c0a723e2f5cd6898afff4c31a0da06905
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAQR5 GCH1 MCUB DISP1	3.25e-05	180	45	4	499d5fe71e0dc20cffdf85e3b3f14eb4e83e3a3d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAQR5 GCH1 MCUB DISP1	3.25e-05	180	45	4	2405aa5699a8d8cf4c6b3dca07510e774728ac50
ToppCell	367C-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PAQR5 HEY1 ACOT11 ADIPOR2	3.61e-05	185	45	4	b57dae20c21f984edd2acee4344d86f033108ebf
ToppCell	367C-Endothelial_cells-Endothelial-B_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PAQR5 HEY1 ACOT11 ADIPOR2	3.61e-05	185	45	4	d3b054d203e575c1bb5455aa7a2e551a0957a760
ToppCell	343B-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PDE6A HEY1 DISP1 ADIPOR2	3.69e-05	186	45	4	080e56113b89138277a2bd2eabddfa6cd1a18b61
ToppCell	343B-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PDE6A HEY1 DISP1 ADIPOR2	3.69e-05	186	45	4	dae6a98963c78bf7518ebab8dc02f173c3b0f7f7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PAQR5 ASTN2 ARHGEF28 ACOT11	4.26e-05	193	45	4	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	droplet-Liver-LIVER-NPC-1m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA2 HEYL ASTN2 BCO1	4.35e-05	194	45	4	415801a3dfacf05f2b603fb424df3d045190a812
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PAQR5 ASTN2 ARHGEF28 ACOT11	4.35e-05	194	45	4	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	droplet-Liver-LIVER-NPC-1m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA2 HEYL ASTN2 BCO1	4.35e-05	194	45	4	256cb33ec90328f2704921fb0fe0fd9812e138b0
ToppCell	droplet-Liver-LIVER-NPC-1m-Mesenchymal\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA2 HEYL ASTN2 BCO1	4.35e-05	194	45	4	7942bc83c1bdca687795b91aa232824d603f9b09
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PAQR5 ASTN2 ARHGEF28 ACOT11	4.35e-05	194	45	4	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PAQR5 ASTN2 ARHGEF28 ACOT11	4.44e-05	195	45	4	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PAQR5 ASTN2 ARHGEF28 ACOT11	4.53e-05	196	45	4	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAQR5 ASTN2 ARHGEF28 ACOT11	4.53e-05	196	45	4	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	AXDND1 AK9 SPEF2 BUB1	4.62e-05	197	45	4	6e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCell	Parenchymal-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	LAMA2 HEYL AK9 DISP1	4.89e-05	200	45	4	8a4c210a3130f7baedf15ecbc0f4903b97da0352
Disease	Cogwheel Rigidity	GCH1 PDE8B	2.07e-05	5	43	2	C0151564
Disease	Muscle Rigidity	GCH1 PDE8B	2.07e-05	5	43	2	C0026837
Disease	Nuchal Rigidity	GCH1 PDE8B	2.07e-05	5	43	2	C1320474
Disease	Gegenhalten	GCH1 PDE8B	2.07e-05	5	43	2	C0231519
Disease	Extensor Rigidity	GCH1 PDE8B	2.07e-05	5	43	2	C0239325
Disease	Extrapyramidal Rigidity	GCH1 PDE8B	2.07e-05	5	43	2	C0277821
Disease	Catatonic Rigidity	GCH1 PDE8B	2.07e-05	5	43	2	C0233608
Disease	plasma trimethylamine N-oxide measurement	EYA3 RHOBTB2	9.27e-05	10	43	2	EFO_0005691
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	HEYL LMAN2 SIK3 MCUB	4.30e-04	243	43	4	EFO_0004612, EFO_0020944
Disease	severe acute respiratory syndrome, COVID-19	AXDND1 ARHGEF28 SGMS1 SPEF2 PDILT	4.67e-04	447	43	5	EFO_0000694, MONDO_0100096
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	HEYL LMAN2 SIK3 MCUB	6.94e-04	276	43	4	EFO_0004612, EFO_0020943
Disease	retinal detachment, retinal break	LAMA2 AXDND1	1.20e-03	35	43	2	EFO_0005773, EFO_0010698
Disease	triglyceride measurement, phospholipid measurement	HEYL SIK3 MCUB	1.27e-03	146	43	3	EFO_0004530, EFO_0004639
Disease	Gastrointestinal Stromal Sarcoma	C2CD3 DISP1	2.15e-03	47	43	2	C3179349
Disease	overall survival, pancreatic carcinoma	ASTN2 ACOT11	2.34e-03	49	43	2	EFO_0000638, EFO_0002618
Disease	glycerophospholipid measurement	PAQR5 LMAN2	2.34e-03	49	43	2	EFO_0007630
Disease	Gastrointestinal Stromal Tumors	C2CD3 DISP1	2.43e-03	50	43	2	C0238198
Disease	susceptibility to common cold measurement	CACNG2 SPEF2	2.83e-03	54	43	2	EFO_0008417

Protein segments in the cluster

Peptide	Gene	Start	Entry
RHVAERLLMHLEEMQ	ARHGEF1	191	Q92888
RLLMHLEEMQHTIST	ARHGEF1	196	Q92888
MLYMIEQVHDCEIIH	BUB1	901	O43683
HSDLTFCEIILMEME	BAZ2A	1796	Q9UIF9
LFQTHENREHLVMME	CLK3	521	P49761
DKFLSFHMEMVVHVD	ACOT11	421	Q8WXI4
FHVDKVHNILAEMVM	AP3S1	111	Q92572
LFMFERVHHGEELHM	DISP1	771	Q96F81
EIVEEQMHILHISVM	ASTN2	196	O75129
THDSKEHLAMMERIL	CLK1	381	P49759
LLQAHHAMEKMEEFV	ADIPOR2	81	Q86V24
LTMEEMIFEVADTHL	EYA3	341	Q99504
MLNEMLLLDIHTHEA	INTS8	611	Q75QN2
LFHVCVILATHMQME	PAQR5	256	Q9NXK6
QDVIFELMQTEMHHI	ARHGEF28	851	Q8N1W1
ELMQTEMHHIQTLFI	ARHGEF28	856	Q8N1W1
EMHHIQTLFIMSEIF	ARHGEF28	861	Q8N1W1
EMVGVLAVHMFIDRH	CACNG2	191	Q9Y698
HEVIVMDMDPFLHCV	OGFOD1	51	Q8N543
ELMEHLPLRVAVHSM	LINC01548	41	A6NM66
MEHMKSLVHRLFTIL	MCUB	161	Q9NWR8
HDIISMKLFQLMVEH	LMAN2	266	Q12907
IFHEHMQELILMKFI	FBXO31	261	Q5XUX0
RDHFMEMLDHTIQIE	ODR4	371	Q5SWX8
EHAIHMMDIAIIATD	PDE6A	656	P16499
IDMVLATEMTKHFEH	PDE8B	721	O95263
EVLQMTVDHLKMLHA	HEYL	86	Q9NQ87
EIVAHMDLMREDLHL	LAMA2	1216	P24043
PVLVIEADHHMERML	TK2	231	O00142
EADHHMERMLELFEQ	TK2	236	O00142
LMEHCFEIHIEMVKG	C2CD3	1001	Q4AC94
IMEELITFHDHALMI	MT-CO2	16	P00403
NIELQHHMDELHISM	AXDND1	691	Q5T1B0
AEILQMTVDHLKMLH	HEY1	91	Q9Y5J3
KDLISELHIMSHMLL	PDILT	266	Q8N807
AFIAEMQMVAEILHH	AK9	211	Q5TCS8
HMVAAEIHQRLMEEE	SPEF2	1266	Q9C093
IVKDIDMFSMCEHHL	GCH1	131	P30793
MHIAHIAELLEVFDL	RHOBTB2	446	Q9BYZ6
MSTECEHLIRHMLVL	SIK3	286	Q9Y2K2
LDVLKHMIHEVEHEM	SPICE1	331	Q8N0Z3
DVDMHMDLHGLFITD	BCO1	506	Q9HAY6
ENLEMHDRMEHLIEK	TUFT1	336	Q9NNX1
LDMIETLKMEHHLEA	SGMS1	61	Q86VZ5
GHEAMHAEMVLILIA	RNF121	46	Q9H920
SADHHIEAMVQLMLH	TAS1R2	186	Q8TE23
DMKAHLIVHMESEII	ZUP1	16	Q96AP4
LEEVFHLMETAPHTM	VIRMA	631	Q69YN4
HDDIMQAVFHIATLM	TSC2	1611	P49815
SEALLIMDLHAHVSM	MYSM1	581	Q5VVJ2