Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase regulator activity	RANBP2 ARHGAP11A TRIO MYCBP2 ARHGAP31 ASAP1 ARHGAP12	4.96e-05	507	39	7	GO:0030695
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RANBP2 ARHGAP11A TRIO MYCBP2 ARHGAP31 ASAP1 ARHGAP12	4.96e-05	507	39	7	GO:0060589
GeneOntologyMolecularFunction	enzyme regulator activity	APC RANBP2 PPP6R1 ARHGAP11A TRIO MYCBP2 BIRC6 ARHGAP31 SLX4 ASAP1 ARHGAP12	5.84e-05	1418	39	11	GO:0030234
GeneOntologyMolecularFunction	GTPase activator activity	RANBP2 ARHGAP11A ARHGAP31 ASAP1 ARHGAP12	2.01e-04	279	39	5	GO:0005096
GeneOntologyMolecularFunction	small GTPase binding	PAK3 RANBP2 PPP6R1 MYCBP2 CDC42BPB	3.83e-04	321	39	5	GO:0031267
GeneOntologyMolecularFunction	GTPase binding	PAK3 RANBP2 PPP6R1 MYCBP2 CDC42BPB	6.44e-04	360	39	5	GO:0051020
GeneOntologyMolecularFunction	enzyme activator activity	RANBP2 ARHGAP11A ARHGAP31 SLX4 ASAP1 ARHGAP12	1.59e-03	656	39	6	GO:0008047
HumanPheno	Aplasia/Hypoplasia of the radius	APC FANCM TRIO SLX4	2.80e-05	82	12	4	HP:0006501
HumanPheno	Aplasia/hypoplasia involving forearm bones	APC FANCM TRIO SLX4	6.13e-05	100	12	4	HP:0006503
HumanPheno	Aplasia/Hypoplasia of fingers	APC FANCM TRIO CDC42BPB ARHGAP31 SLX4	8.42e-05	366	12	6	HP:0006265
HumanPheno	Toe syndactyly	APC FANCM TRIO ARHGAP31 SLX4	1.45e-04	244	12	5	HP:0001770
HumanPheno	Hydrocephalus	PAK3 PLCH1 FANCM CDC42BPB ARHGAP31 SLX4	1.85e-04	421	12	6	HP:0000238
HumanPheno	Alternating esotropia	APC CDC42BPB	2.27e-04	10	12	2	HP:0001137
HumanPheno	Abnormal cerebrospinal fluid morphology	PAK3 RANBP2 PLCH1 FANCM CDC42BPB ARHGAP31 SLX4	2.27e-04	646	12	7	HP:0002921
HumanPheno	Hypoplasia of the ulna	APC FANCM SLX4	2.45e-04	55	12	3	HP:0003022
HumanPheno	Aplasia/Hypoplasia of the ulna	APC FANCM SLX4	3.17e-04	60	12	3	HP:0006495
HumanPheno	Abnormality of globe location or size	APC PAK3 PLCH1 FANCM TRIO CDC42BPB ARHGAP31 RBL2 SLX4	3.22e-04	1246	12	9	HP:0000489
HumanPheno	Recurrent urinary tract infections	CLEC7A FANCM CDC42BPB SLX4	3.54e-04	157	12	4	HP:0000010
HumanPheno	Urinary tract infections	CLEC7A FANCM CDC42BPB SLX4	3.72e-04	159	12	4	HP:0000094
HumanPheno	Urinary bladder inflammation	CLEC7A FANCM CDC42BPB SLX4	3.72e-04	159	12	4	HP:0100577
HumanPheno	Crossed fused renal ectopia	APC CDC42BPB	4.56e-04	14	12	2	HP:0004736
Domain	-	RANBP2 PLCH1 TRIO CDC42BPB ASAP1 ARHGAP12	1.47e-04	391	39	6	2.30.29.30
Domain	PH_dom-like	RANBP2 PLCH1 TRIO CDC42BPB ASAP1 ARHGAP12	2.34e-04	426	39	6	IPR011993
Domain	PH	PLCH1 TRIO CDC42BPB ASAP1 ARHGAP12	2.68e-04	278	39	5	SM00233
Domain	PH_DOMAIN	PLCH1 TRIO CDC42BPB ASAP1 ARHGAP12	2.73e-04	279	39	5	PS50003
Domain	-	PAK3 CDC42BPB	2.77e-04	12	39	2	3.90.810.10
Domain	PH_domain	PLCH1 TRIO CDC42BPB ASAP1 ARHGAP12	2.77e-04	280	39	5	IPR001849
Domain	RhoGAP	ARHGAP11A ARHGAP31 ARHGAP12	2.92e-04	62	39	3	SM00324
Domain	RhoGAP	ARHGAP11A ARHGAP31 ARHGAP12	3.07e-04	63	39	3	PF00620
Domain	RHOGAP	ARHGAP11A ARHGAP31 ARHGAP12	3.21e-04	64	39	3	PS50238
Domain	RhoGAP_dom	ARHGAP11A ARHGAP31 ARHGAP12	3.21e-04	64	39	3	IPR000198
Domain	-	ARHGAP11A ARHGAP31 ARHGAP12	3.21e-04	64	39	3	1.10.555.10
Domain	PBD	PAK3 CDC42BPB	5.01e-04	16	39	2	SM00285
Domain	PBD	PAK3 CDC42BPB	5.66e-04	17	39	2	PF00786
Domain	CRIB	PAK3 CDC42BPB	7.88e-04	20	39	2	PS50108
Domain	Rho_GTPase_activation_prot	ARHGAP11A ARHGAP31 ARHGAP12	8.17e-04	88	39	3	IPR008936
Domain	CRIB_dom	PAK3 CDC42BPB	8.70e-04	21	39	2	IPR000095
Domain	PH	TRIO CDC42BPB ASAP1 ARHGAP12	1.29e-03	229	39	4	PF00169
Domain	C2	SYT16 PLCH1 INPP4B	3.22e-03	142	39	3	PS50004
Domain	-	SYT16 PLCH1 INPP4B	3.62e-03	148	39	3	2.60.40.150
Domain	C2_dom	SYT16 PLCH1 INPP4B	4.82e-03	164	39	3	IPR000008
Domain	SH3_1	TRIO ASAP1 ARHGAP12	4.82e-03	164	39	3	PF00018
Pathway	REACTOME_RHOJ_GTPASE_CYCLE	PAK3 TRIO CDC42BPB	1.72e-04	55	28	3	M41815
Pathway	REACTOME_RHO_GTPASE_CYCLE	PAK3 ARHGAP11A TRIO CDC42BPB ARHGAP31 ARHGAP12	1.85e-04	439	28	6	MM15595
Pathway	REACTOME_RHO_GTPASE_CYCLE	PAK3 ARHGAP11A TRIO CDC42BPB ARHGAP31 ARHGAP12	2.12e-04	450	28	6	M27078
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	PAK3 RANBP2 ARHGAP11A TRIO CDC42BPB ARHGAP31 ARHGAP12	2.15e-04	649	28	7	MM15690
Pathway	REACTOME_CDC42_GTPASE_CYCLE	PAK3 TRIO CDC42BPB ARHGAP31	2.34e-04	155	28	4	M41808
Pathway	REACTOME_RAC1_GTPASE_CYCLE	PAK3 TRIO ARHGAP31 ARHGAP12	3.72e-04	175	28	4	MM15599
Pathway	KEGG_MEDICUS_REFERENCE_LESION_BYPASS_BY_TLS_AND_DSB_FORMATION	SLX4 REV1	3.93e-04	15	28	2	M47854
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	PAK3 RANBP2 ARHGAP11A TRIO CDC42BPB ARHGAP31 ARHGAP12	4.06e-04	720	28	7	M41838
Pathway	REACTOME_RAC1_GTPASE_CYCLE	PAK3 TRIO ARHGAP31 ARHGAP12	4.50e-04	184	28	4	M41809
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	APC PAK3 RANBP2 LRRC7 PPP6R1 WASHC2C TRIO MYCBP2 BIRC6 CDC42BPB PCM1 ASAP1	3.44e-09	1139	40	12	36417873
Pubmed	A human MAP kinase interactome.	USP53 APC PAK3 RANBP2 HIVEP1 CDC42BPB ARHGAP31 KIF26B ASAP1	3.51e-09	486	40	9	20936779
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	APC PAK3 RANBP2 LRRC7 PPP6R1 SPATS2 FAM120A TRIO MYCBP2 CDC42BPB PCM1	7.69e-09	963	40	11	28671696
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	APC RANBP2 PPP6R1 HIVEP1 MYCBP2 BIRC6 PCM1 PRDM2	2.24e-08	418	40	8	34709266
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	APC RANBP2 SPATS2 FAM120A WASHC2C TRIO PCM1 ARHGAP12	5.98e-08	475	40	8	31040226
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	RANBP2 HIVEP1 FAM120A TRIO MYCBP2 BIRC6 CDC42BPB ASAP1	8.46e-08	497	40	8	23414517
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	APC PPP6R1 FAM120A TRIO KIF26B PCM1	1.42e-07	209	40	6	36779422
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	USP53 APC RANBP2 FAM120A WASHC2C TRIO PCM1 ASAP1 ARHGAP12	4.26e-07	853	40	9	28718761
Pubmed	Dectin-1 and IL-17A suppress murine asthma induced by Aspergillus versicolor but not Cladosporium cladosporioides due to differences in β-glucan surface exposure.	CLEC7A IL17A	1.29e-06	2	40	2	22962686
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FAM120A PLCH1 FANCM BIRC6 CDC42BPB MAML3 SLX4	1.37e-06	493	40	7	15368895
Pubmed	Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis.	APC IL17A	3.87e-06	3	40	2	20212110
Pubmed	Neutrophils produce interleukin 17A (IL-17A) in a dectin-1- and IL-23-dependent manner during invasive fungal infection.	CLEC7A IL17A	3.87e-06	3	40	2	21807912
Pubmed	Regulatory T-cell Response to Enterotoxigenic Bacteroides fragilis Colonization Triggers IL17-Dependent Colon Carcinogenesis.	APC IL17A	3.87e-06	3	40	2	26201900
Pubmed	Spontaneous Intestinal Tumorigenesis in Apc (/Min+) Mice Requires Altered T Cell Development with IL-17A.	APC IL17A	3.87e-06	3	40	2	26146642
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	USP53 APC HIVEP1 PLCH1 TRIO MYCBP2 KIF26B PCM1	5.21e-06	861	40	8	36931259
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	USP53 PAK3 LRRC7 SPATS2 FAM120A TRIO MYCBP2 CDC42BPB MAML3 PCM1	5.25e-06	1489	40	10	28611215
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	LRRIQ1 WDR97 MAML3 SLX4	7.11e-06	107	40	4	11347906
Pubmed	Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1.	CLEC7A IL17A	7.73e-06	4	40	2	20299682
Pubmed	Nup358 interacts with APC and plays a role in cell polarization.	APC RANBP2	7.73e-06	4	40	2	19654215
Pubmed	MicroRNA-146a limits tumorigenic inflammation in colorectal cancer.	APC IL17A	7.73e-06	4	40	2	33893298
Pubmed	Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis.	APC IL17A	1.29e-05	5	40	2	26880802
Pubmed	CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling.	PPP6R1 CDC42BPB	1.29e-05	5	40	2	25743393
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	RANBP2 WASHC2C PCM1 ARHGAP12	1.68e-05	133	40	4	15144186
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	APC FAM120A PLCH1 TRIO MYCBP2 BIRC6 PCM1	1.83e-05	733	40	7	34672954
Pubmed	Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.	CLEC7A IL17A	1.93e-05	6	40	2	17450144
Pubmed	Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis.	APC IL17A	1.93e-05	6	40	2	24412611
Pubmed	Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF.	APC ASAP1	1.93e-05	6	40	2	18786926
Pubmed	Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.	APC IL17A	1.93e-05	6	40	2	30650375
Pubmed	Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans.	CLEC7A IL17A	2.70e-05	7	40	2	20493731
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	APC ARPC5L LRRC7 FAM120A PLCH1 TRIO CDC42BPB PCM1 ASAP1	2.84e-05	1431	40	9	37142655
Pubmed	Large-scale analysis of the human ubiquitin-related proteome.	APC PPP6R1 HIVEP1 MYCBP2 BIRC6	2.91e-05	313	40	5	16196087
Pubmed	Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer.	APC IL17A	3.60e-05	8	40	2	23241743
Pubmed	In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells.	APC IL17A	4.62e-05	9	40	2	18504307
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	APC PPP6R1 HIVEP1 WASHC2C SLX4 PCM1	5.36e-05	588	40	6	38580884
Pubmed	Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.	APC IL17A	7.05e-05	11	40	2	23034650
Pubmed	Pairwise Stimulations of Pathogen-Sensing Pathways Predict Immune Responses to Multi-adjuvant Combinations.	CLEC7A IL17A	7.05e-05	11	40	2	33113356
Pubmed	Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.	APC IL17A	7.05e-05	11	40	2	29398651
Pubmed	Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2.	CLEC7A IL17A	7.05e-05	11	40	2	24362892
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	APC HIVEP1 RBL2 CECR2 PRDM2	9.06e-05	398	40	5	35016035
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	APC FAM120A TRIO MYCBP2 CDC42BPB RBL2 SLX4 PCM1	9.11e-05	1285	40	8	35914814
Pubmed	PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway.	PAK3 CDC42BPB	1.16e-04	14	40	2	18586681
Pubmed	Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22.	APC IL17A	1.16e-04	14	40	2	36630911
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	RANBP2 ARHGAP11A SLX4 REV1	1.23e-04	222	40	4	37071664
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	APC ARPC5L LRRC7 SPATS2 CDC42BPB	1.30e-04	430	40	5	32581705
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	APC HIVEP1 FAM120A PCM1	1.32e-04	226	40	4	25900982
Pubmed	Genomic analysis of mouse retinal development.	APC PAK3 FAM120A WASHC2C PLCH1 ARHGAP11A ARHGAP31	1.34e-04	1006	40	7	15226823
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	APC RANBP2 FAM120A PLCH1	1.46e-04	232	40	4	25515538
Pubmed	USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination.	APC RANBP2	1.53e-04	16	40	2	29045831
Pubmed	Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection.	CLEC7A IL17A	1.53e-04	16	40	2	29576482
Pubmed	Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.	FANCM SLX4	1.53e-04	16	40	2	27760317
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	APC RANBP2 SPATS2 FAM120A MYCBP2 CDC42BPB	1.67e-04	724	40	6	36232890
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RANBP2 PPP6R1 TRIO MYCBP2 BIRC6 CDC42BPB ASAP1	1.74e-04	1049	40	7	27880917
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	LRRC7 PPP6R1 ARHGAP11A BIRC6 KIF26B PRDM2	1.83e-04	736	40	6	29676528
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	APC RANBP2 KIF26B PCM1	2.13e-04	256	40	4	33397691
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	APC ARHGAP11A MYCBP2	2.24e-04	102	40	3	15778465
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	BIRC6 ARHGAP31 ASAP1	2.30e-04	103	40	3	10574462
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RANBP2 HIVEP1 WASHC2C MYCBP2 PCM1 PRDM2	2.40e-04	774	40	6	15302935
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	APC RANBP2 FAM120A WASHC2C PCM1	2.69e-04	503	40	5	16964243
Pubmed	Fanconi Anemia	FANCM SLX4	3.21e-04	23	40	2	20301575
Pubmed	Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.	MYCBP2 CDC42BPB	3.80e-04	25	40	2	12522145
Pubmed	Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development.	LRRC7 ARHGAP12	4.78e-04	28	40	2	38324473
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	APC FAM120A TRIO MYCBP2 BIRC6 CDC42BPB PCM1	6.26e-04	1297	40	7	33545068
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	APC LRRC7 MYCBP2 PCM1	6.70e-04	347	40	4	17114649
Pubmed	Interaction network of human early embryonic transcription factors.	RANBP2 HIVEP1 SLX4 PRDM2	7.00e-04	351	40	4	38297188
Pubmed	Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization.	PAK3 PCM1	7.07e-04	34	40	2	23533177
Pubmed	Systematic and quantitative assessment of the ubiquitin-modified proteome.	PPP6R1 HIVEP1 MYCBP2	8.03e-04	158	40	3	21906983
Pubmed	A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.	PPP6R1 HIVEP1 MYCBP2	8.64e-04	162	40	3	21890473
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RANBP2 FAM120A MYCBP2 BIRC6 PCM1	8.78e-04	653	40	5	22586326
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	RANBP2 SPATS2 FAM120A RBL2 ASAP1	8.90e-04	655	40	5	35819319
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	CDC42BPB ARHGAP31 KIF26B INPP4B	9.12e-04	377	40	4	38117590
Interaction	PHF21A interactions	APC RANBP2 PPP6R1 HIVEP1 MYCBP2 BIRC6 PCM1	3.75e-06	343	39	7	int:PHF21A
Interaction	GOLGA1 interactions	APC PPP6R1 WASHC2C BIRC6 PCM1	2.62e-05	183	39	5	int:GOLGA1
Interaction	GSK3A interactions	APC PPP6R1 FAM120A TRIO KIF26B SLX4 PCM1	2.66e-05	464	39	7	int:GSK3A
Interaction	FXR1 interactions	PAK3 RANBP2 HIVEP1 SPATS2 FAM120A MYCBP2 CECR2 PCM1	3.89e-05	679	39	8	int:FXR1
Interaction	RCOR1 interactions	APC RANBP2 PPP6R1 HIVEP1 MYCBP2 BIRC6 PCM1	3.97e-05	494	39	7	int:RCOR1
Interaction	PCNA interactions	APC RANBP2 ARHGAP11A FANCM ARHGAP31 SLX4 REV1	4.13e-05	497	39	7	int:PCNA
Interaction	PLK1 interactions	APC RANBP2 PPP6R1 MYCBP2 BIRC6 SLX4 PCM1	4.86e-05	510	39	7	int:PLK1
Interaction	CDKL5 interactions	APC RANBP2 LRRC7 PCM1	6.62e-05	113	39	4	int:CDKL5
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP11A ARHGAP31 ARHGAP12	8.47e-05	50	31	3	721
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	FANCM SLX4	5.30e-04	20	31	2	548
Coexpression	GSE44732_UNSTIM_VS_IL27_STIM_IMATURE_DC_UP	USP53 CLEC7A ARPC5L ARHGAP31 ASAP1	1.15e-05	200	39	5	M9699
CoexpressionAtlas	FacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#2	APC HIVEP1 FAM120A WASHC2C FANCM TRIO MYCBP2 MAML3 PCM1	6.43e-07	564	39	9	Facebase_RNAseq_e9.5_Mandibular Arch_2500_K2
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A MYCBP2 CECR2 PCM1 ASAP1	6.01e-07	182	40	5	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A MYCBP2 CECR2 PCM1 ASAP1	6.52e-07	185	40	5	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Teffector/EM_CD4\|GI_large-bowel / Manually curated celltypes from each tissue	APC PAK3 MAML3 INPP4B	1.15e-05	156	40	4	01f2c0c6a936dfb59bc727feef428a906ad2a80b
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APC MYCBP2 BIRC6 PCM1	2.21e-05	184	40	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TRIO BIRC6 MAML3 ASAP1	2.66e-05	193	40	4	779276e775cb2492e8dd36436295a536084a6415
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RANBP2 ARHGAP31 ASAP1 PRDM2	2.71e-05	194	40	4	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	control-Lymphoid-Treg\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CLEC7A IL17A RBL2 INPP4B	2.77e-05	195	40	4	66959ae839eb60a573da06bdd227090ebb5bb9ed
ToppCell	390C-Myeloid-Dendritic-cDC1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CLEC7A PAK3 SPATS2 ASAP1	2.94e-05	198	40	4	2bba5a2f584b00d35d008d9c2d8fb3e712fc3a73
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	PAK3 SYT16 LRRC7 MYCBP2	3.05e-05	200	40	4	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MYCBP2 BIRC6 PCM1 PRDM2	3.05e-05	200	40	4	12f1685ce8f218433068e090c9d839cd5a1910bf
Drug	irinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A	HIVEP1 PLCH1 ARHGAP11A TRIO ARHGAP12	1.15e-05	174	39	5	7530_DN
Drug	Hesperetin [520-33-2]; Down 200; 13.2uM; PC3; HG-U133A	APC HIVEP1 TRIO PCM1 PRDM2	1.94e-05	194	39	5	1947_DN
Drug	Imipenem [74431-23-5]; Up 200; 13.4uM; PC3; HT_HG-U133A	PLCH1 TRIO SLC22A14 PCM1 PRDM2	2.14e-05	198	39	5	7294_UP
Disease	Leukemia, Myelocytic, Acute	FANCM TRIO SLX4 INPP4B	8.00e-05	173	39	4	C0023467
Disease	cognitive function measurement, self reported educational attainment	FAM120A MYCBP2 BIRC6 RBL2 MAML3	1.01e-04	355	39	5	EFO_0004784, EFO_0008354
Disease	Bone marrow hypocellularity	FANCM SLX4	2.57e-04	18	39	2	C1855710
Disease	Adenocarcinoma of large intestine	APC PAK3 CDC42BPB	2.80e-04	96	39	3	C1319315
Disease	Pancreatic carcinoma	APC INPP4B	2.87e-04	19	39	2	C0235974
Disease	Fanconi Anemia	FANCM SLX4	5.01e-04	25	39	2	C0015625
Disease	Acute monocytic leukemia	FANCM SLX4	5.42e-04	26	39	2	C0023465
Disease	Pancytopenia	FANCM SLX4	5.42e-04	26	39	2	C0030312
Disease	stimulant use measurement	HIVEP1 ASAP1	6.30e-04	28	39	2	EFO_0600076
Disease	Miller Dieker syndrome	FANCM SLX4	6.76e-04	29	39	2	C0265219
Disease	verbal-numerical reasoning measurement	FAM120A BIRC6 RBL2	6.95e-04	131	39	3	EFO_0008394
Disease	Bladder Neoplasm	INPP4B ASAP1 PRDM2	8.43e-04	140	39	3	C0005695
Disease	neuroticism measurement, cognitive function measurement	APC HIVEP1 FAM120A BIRC6 RBL2	8.57e-04	566	39	5	EFO_0007660, EFO_0008354
Disease	Malignant neoplasm of urinary bladder	INPP4B ASAP1 PRDM2	8.61e-04	141	39	3	C0005684
Disease	Abnormality of radial ray	FANCM SLX4	8.76e-04	33	39	2	C4228778
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	SYT16 HIVEP1 MAML3 PDILT	1.33e-03	364	39	4	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	health study participation	FAM120A BIRC6 RBL2	2.18e-03	195	39	3	EFO_0010130
Disease	cognitive function measurement	LRRC7 HIVEP1 FAM120A BIRC6 RBL2 MAML3 REV1	2.47e-03	1434	39	7	EFO_0008354
Disease	eye morphology measurement	FAM120A WASHC2C PCM1	2.99e-03	218	39	3	EFO_0007858
Disease	MYELODYSPLASTIC SYNDROME	FANCM SLX4	3.56e-03	67	39	2	C3463824
Disease	body fat percentage	SYT16 HIVEP1 MAML3 PDILT	3.85e-03	488	39	4	EFO_0007800

Protein segments in the cluster

Peptide	Gene	Start	Entry
NNLHTQSLNRSSKGS	BIRC6	2206	Q9NR09
NHNAATKRQSSLSAS	CECR2	1321	Q9BXF3
QELKLNSSNSASPHR	RANBP2	826	P49792
SRSHQNSPTELNKDR	RBL2	946	Q08999
AFHAALRNSPVNTKN	ARPC5L	56	Q9BPX5
NNRDSSALNHSSKPL	PAK3	21	O75914
NTKPLTHFNADLSQR	MAML3	601	Q96JK9
AENANSNPLLSSKSR	LRRC7	786	Q96NW7
LLNSASQHSPDSLKN	INPP4B	431	O15327
LDQKNRASPQHSASG	KIF26B	1606	Q2KJY2
SNQALIPRDHSKNFT	FANCM	1276	Q8IYD8
RDQHLNNSSASPQRS	PCM1	421	Q15154
KTCNTNPHLNALSTD	FAM120A	1086	Q9NZB2
LHGSSRALSNSNRDK	CDC42BPB	471	Q9Y5S2
IHNRNTNTNPKRSSD	IL17A	51	Q16552
QKNHLAPTNSDSTLQ	LRRIQ1	1231	Q96JM4
NDSHSPKVSSQNRTR	ARHGAP12	161	Q8IWW6
ANSQLSTSQPSLRHK	CUSTOS	51	Q96C57
ISHATSNRQPAKLNL	ASAP1	356	Q9ULH1
PLSESLNHSSQIRNK	SLC22A14	566	Q9Y267
SPASSDKNSNSNHRR	PRDM2	1501	Q13029
LFHNPSSKQSRNLAE	PDILT	66	Q8N807
ATSCELTPSNLNNKH	ARHGAP11A	561	Q6P4F7
LNNKHNSNITSSPLS	ARHGAP11A	571	Q6P4F7
SAQNSSPSLSQHAKD	SYT16	101	Q17RD7
FNLNTNSLHSAVPKR	TEX53	36	A0A1B0GU33
RSLSPNHNTLQTLKS	MYCBP2	2786	O75592
LTQSNPDHSSSRSQK	SLX4	1126	Q8IY92
KRQNQLHPSSAQSRS	APC	1226	P25054
SRNKENHSQPTQSSL	CLEC7A	86	Q9BXN2
QKFPTDNISSSNRSH	USP53	406	Q70EK8
IHNSQQPRNAAKSLS	SPATS2	196	Q86XZ4
NSFSLSPLHSNTKIN	REV1	296	Q9UBZ9
ALASLSPHSNQQLDS	WDR97	1116	A6NE52
HAQKSLDVSPRNLSQ	SH2D7	196	A6NKC9
LPAQADTLHSANKSR	WASHC2C	996	Q9Y4E1
PRHSDKQNSKNAASE	ARHGAP31	841	Q2M1Z3
LFNKNPRHSSSENNS	PLCH1	891	Q4KWH8
PSKDENQHSNASQSL	PPP6R1	201	Q9UPN7
IQHTNSLSRPNSFDK	HIVEP1	1136	P15822
SRHPSLISSDSNNLK	TMEM25	271	Q86YD3
QQLRDSAISSNKTPH	TRIO	736	O75962