Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alpha-tocopherol omega-hydroxylase activity	CYP4F8 CYP4F12	8.83e-05	5	60	2	GO:0052871
GeneOntologyMolecularFunction	actin binding	FMNL3 SPTBN5 KLHL2 PHACTR3 DAAM2 AFDN ADD1 ADD3	8.86e-05	479	60	8	GO:0003779
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4F8 CYP4F12	1.85e-04	7	60	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4F8 CYP4F12	1.85e-04	7	60	2	GO:0018685
GeneOntologyMolecularFunction	dynein intermediate chain binding	SPTBN5 DNAAF6 DNAH5	1.86e-04	37	60	3	GO:0045505
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4F8 CYP4F12	3.93e-04	10	60	2	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4F8 CYP4F12	3.93e-04	10	60	2	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4F8 CYP4F12	3.93e-04	10	60	2	GO:0102033
GeneOntologyMolecularFunction	actin filament binding	FMNL3 SPTBN5 AFDN ADD1 ADD3	5.97e-04	227	60	5	GO:0051015
GeneOntologyMolecularFunction	structural constituent of cytoskeleton	KRT6B PPL ADD1 ADD3	6.31e-04	130	60	4	GO:0005200
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4F8 CYP4F12	6.78e-04	13	60	2	GO:0016713
GeneOntologyMolecularFunction	arachidonate binding	CYP4F8 CYP4F12	9.09e-04	15	60	2	GO:0050544
GeneOntologyMolecularFunction	icosanoid binding	CYP4F8 CYP4F12	1.04e-03	16	60	2	GO:0050542
GeneOntologyMolecularFunction	icosatetraenoic acid binding	CYP4F8 CYP4F12	1.04e-03	16	60	2	GO:0050543
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP4F8 CYP4F12	2.35e-03	24	60	2	GO:0008392
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP4F8 CYP4F12	2.97e-03	27	60	2	GO:0008391
GeneOntologyMolecularFunction	long-chain fatty acid binding	CYP4F8 CYP4F12	3.19e-03	28	60	2	GO:0036041
GeneOntologyMolecularFunction	cadherin binding	CDH22 AFDN ARHGAP18 PPL ADD1	3.48e-03	339	60	5	GO:0045296
GeneOntologyMolecularFunction	protein tyrosine phosphatase activity	CDC14C PTPN14 PTPRU	3.69e-03	103	60	3	GO:0004725
GeneOntologyBiologicalProcess	pore complex assembly	ANO6 NUP98 AFDN	4.18e-05	23	61	3	GO:0046931
GeneOntologyBiologicalProcess	regulation of actin filament polymerization	SPTBN5 DAAM2 ARHGAP18 ADD1 ADD3	9.81e-05	156	61	5	GO:0030833
GeneOntologyBiologicalProcess	leukotriene B4 catabolic process	CYP4F8 CYP4F12	1.28e-04	6	61	2	GO:0036101
GeneOntologyBiologicalProcess	keratinization	KRT6B TCHH KRT6C PPL	1.28e-04	87	61	4	GO:0031424
GeneOntologyBiologicalProcess	regulation of actin polymerization or depolymerization	SPTBN5 DAAM2 ARHGAP18 ADD1 ADD3	1.77e-04	177	61	5	GO:0008064
GeneOntologyBiologicalProcess	leukotriene B4 metabolic process	CYP4F8 CYP4F12	1.79e-04	7	61	2	GO:0036102
GeneOntologyBiologicalProcess	regulation of actin filament length	SPTBN5 DAAM2 ARHGAP18 ADD1 ADD3	1.92e-04	180	61	5	GO:0030832
GeneOntologyBiologicalProcess	intermediate filament cytoskeleton organization	KRT6B TCHH KRT6C PPL	2.11e-04	99	61	4	GO:0045104
GeneOntologyBiologicalProcess	intermediate filament-based process	KRT6B TCHH KRT6C PPL	2.20e-04	100	61	4	GO:0045103
GeneOntologyBiologicalProcess	leukotriene catabolic process	CYP4F8 CYP4F12	2.38e-04	8	61	2	GO:0036100
GeneOntologyBiologicalProcess	actin filament polymerization	SPTBN5 DAAM2 ARHGAP18 ADD1 ADD3	2.46e-04	190	61	5	GO:0030041
GeneOntologyBiologicalProcess	regulation of cellular component size	SPTBN5 ANO6 SMURF1 DAAM2 ARHGAP18 ADD1 ADD3	2.55e-04	426	61	7	GO:0032535
GeneOntologyBiologicalProcess	actin filament capping	SPTBN5 ADD1 ADD3	3.41e-04	46	61	3	GO:0051693
GeneOntologyBiologicalProcess	cell-cell adhesion mediated by cadherin	CDH22 AFDN PTPRU	4.37e-04	50	61	3	GO:0044331
GeneOntologyBiologicalProcess	positive regulation of cell-cell adhesion mediated by cadherin	AFDN PTPRU	4.65e-04	11	61	2	GO:2000049
GeneOntologyBiologicalProcess	icosanoid catabolic process	CYP4F8 CYP4F12	4.65e-04	11	61	2	GO:1901523
GeneOntologyBiologicalProcess	negative regulation of actin filament depolymerization	SPTBN5 ADD1 ADD3	4.91e-04	52	61	3	GO:0030835
GeneOntologyBiologicalProcess	actin polymerization or depolymerization	SPTBN5 DAAM2 ARHGAP18 ADD1 ADD3	5.03e-04	222	61	5	GO:0008154
GeneOntologyBiologicalProcess	long-chain fatty acid catabolic process	CYP4F8 CYP4F12	5.57e-04	12	61	2	GO:0042758
GeneOntologyBiologicalProcess	regulation of protein polymerization	SPTBN5 DAAM2 ARHGAP18 ADD1 ADD3	6.03e-04	231	61	5	GO:0032271
GeneOntologyBiologicalProcess	lateral ventricle development	KDM2B DNAH5	7.65e-04	14	61	2	GO:0021670
GeneOntologyBiologicalProcess	omega-hydroxylase P450 pathway	CYP4F8 CYP4F12	7.65e-04	14	61	2	GO:0097267
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection assembly	CDC14C FMNL3 TBC1D16 ANO6 DAAM2 DNAAF6 MSTN DNAH5	7.66e-04	670	61	8	GO:0120031
GeneOntologyBiologicalProcess	regulation of actin filament depolymerization	SPTBN5 ADD1 ADD3	7.84e-04	61	61	3	GO:0030834
GeneOntologyBiologicalProcess	adherens junction organization	CDH22 AFDN ADD1	7.84e-04	61	61	3	GO:0034332
GeneOntologyBiologicalProcess	regulation of protein-containing complex disassembly	SPTBN5 ADD1 ADD3 TECPR1	8.73e-04	144	61	4	GO:0043244
GeneOntologyBiologicalProcess	rRNA catabolic process	SLFN13 SLFN11	8.81e-04	15	61	2	GO:0016075
GeneOntologyBiologicalProcess	cell projection assembly	CDC14C FMNL3 TBC1D16 ANO6 DAAM2 DNAAF6 MSTN DNAH5	8.85e-04	685	61	8	GO:0030031
GeneOntologyBiologicalProcess	regulation of actin cytoskeleton organization	SPTBN5 CELSR1 DAAM2 ARHGAP18 ADD1 ADD3	9.38e-04	384	61	6	GO:0032956
Domain	DUF2075	SLFN13 SLFN11 SLFN5	2.99e-08	3	59	3	IPR018647
Domain	DUF2075	SLFN13 SLFN11 SLFN5	2.99e-08	3	59	3	PF09848
Domain	AlbA_2	SLFN13 SLFN11 SLFN5	1.04e-06	7	59	3	PF04326
Domain	Schlafen	SLFN13 SLFN11 SLFN5	1.04e-06	7	59	3	IPR029684
Domain	Schlafen_AAA_dom	SLFN13 SLFN11 SLFN5	1.04e-06	7	59	3	IPR007421
Domain	Aldolase_II/adducin_N	ADD1 ADD3	5.86e-05	4	59	2	IPR001303
Domain	Aldolase_II	ADD1 ADD3	5.86e-05	4	59	2	PF00596
Domain	-	ADD1 ADD3	5.86e-05	4	59	2	3.40.225.10
Domain	Aldolase_II	ADD1 ADD3	5.86e-05	4	59	2	SM01007
Domain	Drf_GBD	FMNL3 DAAM2	3.48e-04	9	59	2	PF06371
Domain	FH3_dom	FMNL3 DAAM2	3.48e-04	9	59	2	IPR010472
Domain	GTPase-bd	FMNL3 DAAM2	3.48e-04	9	59	2	IPR010473
Domain	Drf_FH3	FMNL3 DAAM2	3.48e-04	9	59	2	PF06367
Domain	Drf_FH3	FMNL3 DAAM2	3.48e-04	9	59	2	SM01139
Domain	Drf_GBD	FMNL3 DAAM2	3.48e-04	9	59	2	SM01140
Domain	GBD/FH3_dom	FMNL3 DAAM2	5.30e-04	11	59	2	IPR014768
Domain	GBD_FH3	FMNL3 DAAM2	5.30e-04	11	59	2	PS51232
Domain	FH2	FMNL3 DAAM2	1.00e-03	15	59	2	PS51444
Domain	FH2_Formin	FMNL3 DAAM2	1.00e-03	15	59	2	IPR015425
Domain	FH2	FMNL3 DAAM2	1.00e-03	15	59	2	PF02181
Domain	FH2	FMNL3 DAAM2	1.00e-03	15	59	2	SM00498
Domain	NAP	NAP1L2 NAP1L3	1.29e-03	17	59	2	PF00956
Domain	NAP_family	NAP1L2 NAP1L3	1.29e-03	17	59	2	IPR002164
Domain	Keratin_2_head	KRT6B KRT6C	2.59e-03	24	59	2	IPR032444
Domain	Keratin_2_head	KRT6B KRT6C	2.59e-03	24	59	2	PF16208
Domain	Keratin_II	KRT6B KRT6C	3.04e-03	26	59	2	IPR003054
Domain	HECT	HECW2 SMURF1	3.27e-03	27	59	2	PF00632
Domain	HECTc	HECW2 SMURF1	3.27e-03	27	59	2	SM00119
Domain	HECT_dom	HECW2 SMURF1	3.27e-03	27	59	2	IPR000569
Domain	HECT	HECW2 SMURF1	3.27e-03	27	59	2	PS50237
Domain	Spectrin_repeat	SPTBN5 PPL	3.77e-03	29	59	2	IPR002017
Domain	EGF_LAM_2	CELSR1 STAB1	4.03e-03	30	59	2	PS50027
Domain	EGF_LAM_1	CELSR1 STAB1	4.03e-03	30	59	2	PS01248
Domain	Spectrin/alpha-actinin	SPTBN5 PPL	4.58e-03	32	59	2	IPR018159
Domain	SPEC	SPTBN5 PPL	4.58e-03	32	59	2	SM00150
Domain	Laminin_EGF	CELSR1 STAB1	5.46e-03	35	59	2	PF00053
Domain	EGF_Lam	CELSR1 STAB1	5.46e-03	35	59	2	SM00180
Domain	PTPc	PTPN14 PTPRU	5.77e-03	36	59	2	SM00194
Domain	Laminin_EGF	CELSR1 STAB1	6.41e-03	38	59	2	IPR002049
Domain	TYR_PHOSPHATASE_PTP	PTPN14 PTPRU	6.74e-03	39	59	2	PS50055
Domain	PTPase_domain	PTPN14 PTPRU	7.43e-03	41	59	2	IPR000242
Pubmed	Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.	SLFN13 SLFN11 SLFN5	5.12e-08	5	61	3	29528433
Pubmed	Subcellular localization of the Schlafen protein family.	SLFN13 SLFN11 SLFN5	5.12e-08	5	61	3	18355440
Pubmed	Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.	SLFN13 SLFN11 SLFN5	5.12e-08	5	61	3	24089532
Pubmed	Schlafen, a new family of growth regulatory genes that affect thymocyte development.	SLFN13 SLFN11 SLFN5	1.02e-07	6	61	3	9846487
Pubmed	Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.	SLFN13 SLFN11 SLFN5	1.79e-07	7	61	3	15351786
Pubmed	Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence.	SLFN13 SLFN11 SLFN5	2.86e-07	8	61	3	19619625
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	FMNL3 STK10 SPRY1 PTPN14 ANO6 DAAM2 ADD1 ADD3	3.16e-07	377	61	8	38117590
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	PTPN14 SMG7 GTF3C1 LMO7 KDM2B AFDN ADD1 ADD3 DMAP1	4.77e-07	549	61	9	38280479
Pubmed	Increased expression of phosphorylated adducin in tumor cells.	ADD1 ADD3	3.03e-06	2	61	2	32237935
Pubmed	Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.	SLFN13 SLFN11	3.03e-06	2	61	2	37833372
Pubmed	Effects of genetic variation in adducin on left ventricular diastolic function as assessed by tissue Doppler imaging in a Flemish population.	ADD1 ADD3	3.03e-06	2	61	2	18475162
Pubmed	Adducins regulate remodeling of apical junctions in human epithelial cells.	ADD1 ADD3	3.03e-06	2	61	2	20810786
Pubmed	Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8.	CYP4F8 CYP4F12	3.03e-06	2	61	2	16112640
Pubmed	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.	SLFN13 SLFN11	3.03e-06	2	61	2	29563550
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	STK10 SAFB GTF3C1 LMO7 NUP98 KDM2B AFDN PPL ADD1	7.88e-06	774	61	9	15302935
Pubmed	p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1.	SAFB KHDRBS2	9.07e-06	3	61	2	15345239
Pubmed	Epistatic interaction between alpha- and gamma-adducin influences peripheral and central pulse pressures in white Europeans.	ADD1 ADD3	9.07e-06	3	61	2	15834281
Pubmed	Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay.	KRT6B KRT6C	9.07e-06	3	61	2	29357356
Pubmed	Gly460Trp alpha-adducin mutation as a possible mechanism leading to endolymphatic hydrops in Ménière's syndrome.	ADD1 ADD3	9.07e-06	3	61	2	18667944
Pubmed	Targeted disruption of the beta adducin gene (Add2) causes red blood cell spherocytosis in mice.	ADD1 ADD3	9.07e-06	3	61	2	10485892
Pubmed	Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes.	ADD1 ADD3	9.07e-06	3	61	2	1864459
Pubmed	Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms.	KRT6B KRT6C	9.07e-06	3	61	2	7543104
Pubmed	Arterial properties in relation to genetic variations in the adducin subunits in a white population.	ADD1 ADD3	9.07e-06	3	61	2	18787518
Pubmed	Variable SATB1 Levels Regulate Hematopoietic Stem Cell Heterogeneity with Distinct Lineage Fate.	SATB1 STAB1	9.07e-06	3	61	2	29898394
Pubmed	Role of the adducin family genes in human essential hypertension.	ADD1 ADD3	9.07e-06	3	61	2	15716695
Pubmed	Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.	SLFN13 SLFN11	9.07e-06	3	61	2	38875319
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	KRT6B SAFB PTPN14 GTF3C1 INCENP LMO7 NUP98 BYSL PPL ADD1 ADD3	1.05e-05	1257	61	11	36526897
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SATB1 LMO7 ACO1 NAP1L2 NAP1L3 DAAM2 AFDN CBFB ADD3 DMAP1 STAB1	1.29e-05	1285	61	11	35914814
Pubmed	Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism.	CYP4F8 CYP4F12	1.81e-05	4	61	2	22665481
Pubmed	Metastasis suppressor microRNA-335 targets the formin family of actin nucleators.	FMNL3 DAAM2	1.81e-05	4	61	2	24223803
Pubmed	Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14.	CYP4F8 CYP4F12	1.81e-05	4	61	2	11185557
Pubmed	Effects of pre-exercise feeding on serum hormone concentrations and biomarkers of myostatin and ubiquitin proteasome pathway activity.	SMURF1 MSTN	1.81e-05	4	61	2	22476926
Pubmed	beta-adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the alpha- and gamma-adducin subunits.	ADD1 ADD3	1.81e-05	4	61	2	19900187
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	STK10 SAFB GTF3C1 LMO7 NUP98 AFDN DMAP1	2.82e-05	503	61	7	16964243
Pubmed	Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity.	SATB1 CBFB	3.02e-05	5	61	2	32218434
Pubmed	Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.	CYP4F8 CYP4F12	3.02e-05	5	61	2	22969154
Pubmed	Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation.	CYP4F8 CYP4F12	3.02e-05	5	61	2	21466787
Pubmed	Pachyonychia Congenita	KRT6B KRT6C	3.02e-05	5	61	2	20301457
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FMNL3 SMG7 LMO7 HECW2 KDM2B DMAP1 STAB1	3.88e-05	529	61	7	14621295
Pubmed	The cytochrome P450 4 (CYP4) family.	CYP4F8 CYP4F12	4.52e-05	6	61	2	9068972
Pubmed	Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA.	SAFB KHDRBS2	4.52e-05	6	61	2	19282290
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	LMO7 PROM2 AFDN ARHGAP18 PPL ADD1 ADD3	5.88e-05	565	61	7	25468996
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	INCENP SLFN13 ANO6 NUP98 AFDN PPL ADD1 ADD3	6.20e-05	777	61	8	35844135
Pubmed	Gene-environment interaction in the etiology of mathematical ability using SNP sets.	SAMD3 DNAH5	6.32e-05	7	61	2	20978832
Pubmed	Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.	CYP4F8 CYP4F12	6.32e-05	7	61	2	22160543
Pubmed	TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.	CYP4F8 APOA4 CYP4F12	7.38e-05	46	61	3	25209997
Pubmed	A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation.	NAP1L2 NAP1L3	8.42e-05	8	61	2	17291163
Pubmed	Topical Aminosalicylic Acid Improves Keratinocyte Differentiation in an Inducible Mouse Model of Harlequin Ichthyosis.	KRT6B PPL	8.42e-05	8	61	2	33294854
Pubmed	Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression.	SATB1 KDM2B	1.08e-04	9	61	2	28319097
Pubmed	Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.	SMURF1 CBFB	1.35e-04	10	61	2	15138260
Pubmed	The mouse adducin gene family: alternative splicing and chromosomal localization.	ADD1 ADD3	1.65e-04	11	61	2	10602987
Pubmed	Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA.	KRT6B TCHH	1.97e-04	12	61	2	14610062
Pubmed	Interaction between nucleosome assembly protein 1-like family members.	NAP1L2 NAP1L3	1.97e-04	12	61	2	21333655
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	FMNL3 GTF3C1 HECW2 SMURF1 ATP11C	2.25e-04	313	61	5	38270169
Pubmed	Postnatal gene expression in the normal mouse cornea by SAGE.	KRT6B PTPN14	2.72e-04	14	61	2	14744882
Pubmed	Expression of multiple formins in adult tissues and during developmental stages of mouse brain.	FMNL3 DAAM2	2.72e-04	14	61	2	26272686
Pubmed	Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia.	APOA4 ADD1	3.13e-04	15	61	2	19166692
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	GTF3C1 LMO7 NUP98 DAAM2 ZER1 ATP11C	3.43e-04	533	61	6	25544563
Pubmed	Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method.	SATB1 NAP1L3	3.57e-04	16	61	2	9417904
Pubmed	Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.	APOA4 ADD1	3.57e-04	16	61	2	10391210
Pubmed	A genome wide association study identifies common variants associated with lipid levels in the Chinese population.	PTPN14 APOA4	4.05e-04	17	61	2	24386095
Pubmed	FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals.	SPRY1 CDH22	4.55e-04	18	61	2	12682014
Pubmed	A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.	LMO7 PTPRU ADD1	4.58e-04	85	61	3	23055939
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	GTF3C1 CBFB ADD1 ADD3 DMAP1	4.84e-04	370	61	5	22922362
Pubmed	A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.	PTPN14 LMO7 AFDN	4.90e-04	87	61	3	17979178
Pubmed	SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.	HECW2 SMURF1	5.08e-04	19	61	2	21572392
Pubmed	Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.	FMNL3 ACO1 SLFN11	5.24e-04	89	61	3	23891004
Pubmed	Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS.	SATB1 STAB1	5.63e-04	20	61	2	15733084
Pubmed	Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.	ADD1 ADD3	5.63e-04	20	61	2	18723693
Pubmed	AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis.	KRT6B TCHH	6.22e-04	21	61	2	18824566
Pubmed	Bcl11b/Ctip2 is required for development of lingual papillae in mice.	KRT6B TCHH	6.22e-04	21	61	2	27287879
Pubmed	Heritability and genetic association analysis of cognition in the Diabetes Heart Study.	KLHL2 ARHGAP18	6.22e-04	21	61	2	24684796
Pubmed	Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.	HECW2 SMURF1	6.22e-04	21	61	2	37005481
Pubmed	Proteomic discovery of MNT as a novel interacting partner of E3 ubiquitin ligase E6AP and a key mediator of myeloid differentiation.	KRT6B GTF3C1	8.15e-04	24	61	2	26506232
Pubmed	Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry.	AFDN ADD1 ADD3	8.71e-04	106	61	3	38891874
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	KRT6B SAFB GTF3C1 KRT6C LMO7 KHDRBS2 NUP98 ATP11C PPL	8.77e-04	1442	61	9	35575683
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HECW2 SMURF1	9.57e-04	26	61	2	26949039
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	GTF3C1 INCENP NUP98 SLFN11	9.86e-04	250	61	4	33536335
Pubmed	Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.	KLHL2 ZER1 AFDN	1.25e-03	120	61	3	27565346
Pubmed	iRhom2 mutation leads to aberrant hair follicle differentiation in mice.	TCHH DAAM2	1.28e-03	30	61	2	25546423
Pubmed	BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.	SATB1 NUP98	1.36e-03	31	61	2	23086144
Pubmed	Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.	SPRY1 CDH22 PTPRU	1.43e-03	126	61	3	16284245
Pubmed	HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages.	INCENP LMO7	1.45e-03	32	61	2	27114546
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	KRT6B LMO7 NUP98 BYSL AFDN ADD1	1.53e-03	711	61	6	33022573
Pubmed	Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.	CDH22 NUP98 PTPRU STAB1	1.56e-03	283	61	4	18854154
Pubmed	Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development.	SPRY1 TCHH	1.64e-03	34	61	2	23123965
Pubmed	New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.	APOA4 ADD1	1.73e-03	35	61	2	18513389
Interaction	NAP1L2 interactions	KLHL2 NAP1L2 NAP1L3 DMAP1	6.40e-06	40	61	4	int:NAP1L2
Interaction	MCAM interactions	FMNL3 STK10 SPRY1 PTPN14 ANO6 DAAM2 ATP11C ADD1 ADD3	1.08e-05	468	61	9	int:MCAM
Cytoband	16p12	GTF3C1 HS3ST2	1.56e-04	14	61	2	16p12
Cytoband	17q12	SLFN13 SLFN11 SLFN5	3.20e-04	99	61	3	17q12
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	SLFN13 SLFN11 SLFN5	1.05e-03	149	61	3	chr17q12
Cytoband	19p13.1	CYP4F8 CYP4F12	1.88e-03	48	61	2	19p13.1
Cytoband	12q13.13	KRT6B KRT6C	3.63e-03	67	61	2	12q13.13
GeneFamily	Schlafen family	SLFN13 SLFN11 SLFN5	3.23e-07	7	39	3	1110
GeneFamily	Keratins, type II	KRT6B KRT6C	1.54e-03	27	39	2	609
GeneFamily	Cytochrome P450 family 4	CYP4F8 CYP4F12	2.73e-03	36	39	2	1003
CoexpressionAtlas	gamma delta T cells, Tgd.vg2-.Sp, TCRd+ Vg2- CD44-, Spleen, avg-3	STK10 CELSR1 SATB1 SLFN13 SLFN5 SAMD3 ADD3 TECPR1	1.15e-05	382	60	8	GSM476684_500
ToppCell	droplet-Tongue-nan-24m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCHH LMO7 PROM2 AFDN PPL STAB1	2.12e-07	186	61	6	18c06041c6c8a0ebac17b3c8aaebd67e652d315a
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CELSR1 PTPN14 LMO7 KHDRBS2 AFDN PPL	2.25e-07	188	61	6	eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 LMO7 PHACTR3 AFDN DNAH5 PPL	2.63e-07	193	61	6	f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 LMO7 PHACTR3 AFDN DNAH5 PPL	2.63e-07	193	61	6	42df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 LMO7 PHACTR3 AFDN DNAH5 PPL	2.71e-07	194	61	6	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPRY1 LMO7 DAAM2 ATP11C SAMD3	3.05e-06	164	61	5	b6df1e67a5ce5f2d86f4e1420f4ee931f760bf4d
ToppCell	COVID-19-kidney-Mito-rich_EC\|kidney / Disease (COVID-19 only), tissue and cell type	FMNL3 SPRY1 HECW2 SLFN5 EXOC3L2	5.21e-06	183	61	5	3c4153479fc4ab2d073d92cee120480015555914
ToppCell	Smart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPRY1 GTF3C1 SLFN13 SLFN5 SAMD3	5.64e-06	186	61	5	fc0b488c201a32d829047b58460297df2818b45d
ToppCell	Epithelial-alveolar_epithelial_cell_type_1\|World / Lineage, Cell type, age group and donor	CELSR1 PTPN14 LMO7 KHDRBS2 AFDN	5.64e-06	186	61	5	09d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FMNL3 SPTBN5 SPRY1 HECW2 EXOC3L2	5.79e-06	187	61	5	35c382c0aabd46906113e5db30ea24bb8e658899
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma\|TCGA-Kidney / Sample_Type by Project: Shred V9	FMNL3 SPRY1 HECW2 LOXL2 SLFN11	5.94e-06	188	61	5	e711c7a46d7cfa030ca2982eacc1dae5af5788dd
ToppCell	15-Distal-Epithelial-Secretory_progenitor\|Distal / Age, Tissue, Lineage and Cell class	CELSR1 LMO7 PROM2 DNAH5 PPL	5.94e-06	188	61	5	9a64fb07de611de38d6f24673feb3b81a5e85384
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CELSR1 SATB1 SLFN13 SLFN5 SAMD3	6.42e-06	191	61	5	f1935e8f8467a2bc30588b7f2cc3b94e9c83b268
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CELSR1 SATB1 SLFN13 SLFN5 SAMD3	6.42e-06	191	61	5	1161e465c50c2071764279e01cf08b1048cce0e3
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CELSR1 SATB1 SLFN13 SLFN5 SAMD3	6.42e-06	191	61	5	7a4fe96989f72159385270c712342ba3e1ca6fc3
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CELSR1 SATB1 SLFN13 SLFN5 SAMD3	6.42e-06	191	61	5	c023ca893ceae19b54967096f6e2588dc39fa268
ToppCell	IPF-Epithelial-Basal\|World / Disease state, Lineage and Cell class	CELSR1 LMO7 PROM2 PTPRU PPL	6.58e-06	192	61	5	9b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 LMO7 PHACTR3 DNAH5 PPL	6.75e-06	193	61	5	263d185af6ed80e639f864e4966268e0862c61dc
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCHH LMO7 PROM2 AFDN PPL	6.75e-06	193	61	5	55eab7d2574e9cc2ed8f08e0a7ca7cbf90fb5818
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 LMO7 PHACTR3 DNAH5 PPL	6.75e-06	193	61	5	80e058c224749b5fe0ba3e944b48317c2371cb63
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 LMO7 PHACTR3 DNAH5 PPL	6.75e-06	193	61	5	b991fbbb4618401624f0b3045f0e81a606d3a763
ToppCell	NS-critical-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KRT6B LMO7 PROM2 AFDN PPL	6.92e-06	194	61	5	614d0c25b56957c70f397abb169fd2a860eb1c06
ToppCell	facs-Heart-LA-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN14 LMO7 AFDN SLFN5 STAB1	6.92e-06	194	61	5	33cc4f1d716cb71d54cdedbe9bbdc0d7b17c4777
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-SMG_Basal/Duct-SMG_Basal/Duct\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KRT6B LMO7 PROM2 AFDN PPL	7.64e-06	198	61	5	829377071f65016d31d09175a43c28e95532b404
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-SMG_Basal/Duct\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KRT6B LMO7 PROM2 AFDN PPL	7.64e-06	198	61	5	27a3c1c5ac855dff8d63f44eaa289be3f5bd621a
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CDH22 LMO7 KHDRBS2 SAMD3	4.08e-05	140	61	4	7cc891d676555609add6fc7880735d948a2ad801
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FMNL3 DAAM2 SLFN11 SAMD3	5.07e-05	148	61	4	f85dc34f6a4a15ecffa4fbd5644dea12ce30089b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FMNL3 DAAM2 SLFN11 SAMD3	5.07e-05	148	61	4	4b1fdf90c585f89cee1cf521db4e3fafc9d74d9a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FMNL3 DAAM2 SLFN11 SAMD3	5.07e-05	148	61	4	55826b7e9f79ab78a93abd4fc662bc37aa121471
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|367C / Donor, Lineage, Cell class and subclass (all cells)	FMNL3 BYSL ZER1 TECPR1	5.21e-05	149	61	4	41f28138bde45d0b814e116837e5a32b5e80d54a
ToppCell	facs-Marrow-Granulocytes-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDH22 PHACTR3 SAMD3 TECPR1	5.34e-05	150	61	4	a3a4710820a244116a26204f40e7113a1e7236c5
ToppCell	facs-Marrow-Granulocytes-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDH22 PHACTR3 SAMD3 TECPR1	5.34e-05	150	61	4	13dcd519dacf08d5852aa3e029e0a3308de07321
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DAAM2 ATP11C SLFN5 SAMD3	6.70e-05	159	61	4	5ca96db4281abb5f646150ccf36adc66ab201c78
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D16 SLFN5 SAMD3 TECPR1	6.86e-05	160	61	4	55f599df6e3b7a5a505df4b094c834281311d94a
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D16 SLFN5 SAMD3 TECPR1	6.86e-05	160	61	4	296e53e1e0786346d38db2d4188b9a1c0430627b
ToppCell	droplet-Lung-30m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CDH22 SATB1 PHACTR3 SAMD3	7.03e-05	161	61	4	cd4a736d0cec31477c6e8d3b07a04ede1559854b
ToppCell	droplet-Lung-30m-Hematologic-Lymphocytic_NK_ILC\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CDH22 SATB1 PHACTR3 SAMD3	7.03e-05	161	61	4	28930ba576625b98cc15993d1499e9dc5edbb5a9
ToppCell	droplet-Lung-30m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CDH22 SATB1 PHACTR3 SAMD3	7.20e-05	162	61	4	ccba6d8d644fe56060ad388ec3a062b7e3b9f086
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Sla\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SPTBN5 KHDRBS2 PTPRU HS3ST2	7.20e-05	162	61	4	4d13c271b4f63cf32980e5643b5d5951165fe8b5
ToppCell	droplet-Liver-Hepatocytes-21m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SATB1 PROM2 SAMD3 TECPR1	7.20e-05	162	61	4	eb2900a250fb3e08e479c727c7d3200cbcf37fbc
ToppCell	droplet-Liver-Hepatocytes-21m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SATB1 PROM2 SAMD3 TECPR1	7.20e-05	162	61	4	1ef3084b5766641ec07c6f488c1756239cf3fd61
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	INCENP NUP98 AFDN ARHGAP18	7.38e-05	163	61	4	3efbbdc9cb2613bb76d8c2f07cd4ec1a2c51a622
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	INCENP DNAH5 PPL STAB1	7.55e-05	164	61	4	4307b002fb41ddfc7ab8a6bca66a60942c250052
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CELSR1 PTPN14 KHDRBS2 STAB1	7.55e-05	164	61	4	4cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CELSR1 PTPN14 KHDRBS2 STAB1	7.55e-05	164	61	4	7a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CELSR1 PTPN14 KHDRBS2 STAB1	7.55e-05	164	61	4	5e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCell	PND10-Endothelial-Endothelial_lymphatic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CELSR1 PTPN14 KHDRBS2 STAB1	7.55e-05	164	61	4	f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	INCENP DNAH5 PPL STAB1	7.55e-05	164	61	4	1d84aa5b925f502ee9c5fa39714490f613a58028
ToppCell	droplet-Liver-Npc-21m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDH22 SATB1 PHACTR3 SAMD3	7.73e-05	165	61	4	6708beb0e8094f30cf5cd812e6a67a6db004a580
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor_intermediate_\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CELSR1 LMO7 PROM2 PPL	7.73e-05	165	61	4	f6887c64af0f26e33316bc5587487e24d76ece2a
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CELSR1 PTPN14 PHACTR3 NAP1L3	7.92e-05	166	61	4	1f39c7507ac6881aa1a30f8be22f98a1837d926b
ToppCell	10x5'-blood-Lymphocytic_NK-NK_CD56bright_CD16-\|blood / Manually curated celltypes from each tissue	SPRY1 KRT6B SLFN13 SAMD3	7.92e-05	166	61	4	ba42349a68b22e91a0340bda1ccecd6c7592392f
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CELSR1 PROM2 PHACTR3 PPL	8.48e-05	169	61	4	40b557549fe08c5dc9dba359af35993d68d1640a
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l9\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CELSR1 SATB1 SAMD3 TECPR1	8.68e-05	170	61	4	8e9b5f7bfb61f8d84d0b17fb0c191da4dabad63d
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal-Basal-Basal_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KRT6B PROM2 LOXL2 PPL	9.29e-05	173	61	4	1b2508cc890430bd4b2cf232c633928edb86c57e
ToppCell	367C-Myeloid-Dendritic-cDC_activated\|367C / Donor, Lineage, Cell class and subclass (all cells)	CCNG2 TCHH LOXL2 KDM2B	9.29e-05	173	61	4	94f99f7e7813d6e53e0bedf97087400b1bf00129
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-5\|TCGA-Pancreas / Sample_Type by Project: Shred V9	CELSR1 SMURF1 PTPRU PPL	9.50e-05	174	61	4	73e1ad4007d94fca25ed7c6fbe5d205d4e1b8a3b
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	PTPN14 LMO7 KHDRBS2 AFDN	9.50e-05	174	61	4	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LMO7 HECW2 DAAM2 MSTN	9.71e-05	175	61	4	12f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCell	metastatic_Brain-Endothelial_cells-Lymphatic_ECs\|Endothelial_cells / Location, Cell class and cell subclass	TBC1D16 CELSR1 TCHH PPL	9.92e-05	176	61	4	42541dfe20eb29625d47c0bb79bf3c21a2460340
ToppCell	367C-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CCNG2 LOXL2 KDM2B PTPRU	1.01e-04	177	61	4	a0ff337f11bdb11959ac71805ff94be6b4ec1083
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CELSR1 PTPN14 PTPRU PPL	1.01e-04	177	61	4	cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCell	COVID-19-kidney-REN+Pericyte\|kidney / Disease (COVID-19 only), tissue and cell type	HECW2 DAAM2 ATP11C SAMD3	1.06e-04	179	61	4	342c1cc4444f51b8dcb30d3adc98285a25669c6e
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PTPN14 SATB1 KHDRBS2 HS3ST2	1.08e-04	180	61	4	2ae39e26a8e7d5d4d3e1e71609a8ec36fd9855aa
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HECW2 LOXL2 AFDN ARHGAP18	1.08e-04	180	61	4	544fb373a3346186ec60afe2cfcf141bb04a1eed
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LMO7 DAAM2 SLFN11 MSTN	1.11e-04	181	61	4	a2058d658f07ab6f0a28d2622f3090b4cde6f763
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal-Basal\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KRT6B PROM2 LOXL2 PPL	1.11e-04	181	61	4	6b43dcaeeb02ad5900772b6f16f1581847050e38
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LMO7 DAAM2 SLFN11 MSTN	1.11e-04	181	61	4	526e858a848470b6d2d5248788004d9735ed3add
ToppCell	COPD-Myeloid-DC_Mature\|World / Disease state, Lineage and Cell class	CCNG2 LOXL2 KDM2B ATP11C	1.11e-04	181	61	4	675603a401d92cf9fdcd44e211ec899fa86a0d49
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KRT6B PROM2 LOXL2 PPL	1.11e-04	181	61	4	f50561fdacfb83ba85fe6476e7cbc2bad1ebc826
ToppCell	Control-Epithelial-Basal\|World / Disease state, Lineage and Cell class	CELSR1 LMO7 PTPRU PPL	1.13e-04	182	61	4	759390dde9b18757f7675d13d44c89d0e32f8d93
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CELSR1 PTPN14 LMO7 DNAH5	1.13e-04	182	61	4	215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCell	droplet-Heart-nan-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LMO7 AFDN SLFN5 ARHGAP18	1.13e-04	182	61	4	81279877b920b5a1bc991a07d3031d6458700fe3
ToppCell	Control-Epithelial-Basal\|Control / Disease state, Lineage and Cell class	CELSR1 LMO7 PTPRU PPL	1.13e-04	182	61	4	caddd0a52f0234ea6a916186ffaf2454cdcd80ee
ToppCell	COPD-Epithelial-Basal\|COPD / Disease state, Lineage and Cell class	CELSR1 LMO7 PTPRU PPL	1.15e-04	183	61	4	0f760e393edc91009bf6c7e02eeac039a1dfb4ed
ToppCell	droplet-Tongue-nan-24m-Epithelial-keratinocyte\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT6B PROM2 AFDN PPL	1.15e-04	183	61	4	9e6c96ada930e8559246a270dfc69fb3cbb3bdf3
ToppCell	facs-Trachea-18m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CELSR1 TCHH LMO7 PROM2	1.18e-04	184	61	4	45ff845ceed5960a997545c1009012b65e377d50
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FMNL3 CYP4F8 HECW2 EXOC3L2	1.18e-04	184	61	4	688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PTPN14 LMO7 KHDRBS2 AFDN	1.18e-04	184	61	4	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CELSR1 LMO7 PHACTR3 KHDRBS2	1.18e-04	184	61	4	29c95b814a0b1ad8734ed68b77df29c08594e5ec
ToppCell	facs-Spleen-nan-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D16 CELSR1 SATB1 TECPR1	1.18e-04	184	61	4	c37c623c4a5ff1628486d8a6461fa355ad5c264c
ToppCell	facs-Trachea-18m-Epithelial-airway_epithelial-respiratory_basal_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CELSR1 TCHH LMO7 PROM2	1.18e-04	184	61	4	2cc2646dee3c6001f7c10b7449c17d1935021958
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TBC1D16 CELSR1 LMO7 PPL	1.18e-04	184	61	4	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PTPN14 LMO7 KHDRBS2 AFDN	1.18e-04	184	61	4	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4\|TCGA-Thryoid / Sample_Type by Project: Shred V9	KLHL2 ACO1 ARHGAP18 PPL	1.18e-04	184	61	4	d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTPN14 LMO7 KHDRBS2 AFDN	1.20e-04	185	61	4	1c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D175\|Adult / Lineage, Cell type, age group and donor	PTPN14 LMO7 ANO6 KHDRBS2	1.20e-04	185	61	4	32b4e68e551d435a732f253f6ad83408c759a642
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-maDC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CCNG2 LOXL2 KDM2B ATP11C	1.20e-04	185	61	4	7e3d9f5050e71e91021245c11101e994ae41d22b
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D175\|Adult / Lineage, Cell type, age group and donor	SPTBN5 STK10 ARHGAP18 STAB1	1.20e-04	185	61	4	ab5704b96f1d368911308797d10c7c52766ab134
ToppCell	droplet-Pancreas-Endocrine-18m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMNL3 INCENP HECW2 SLFN5	1.20e-04	185	61	4	512a195ebbae445afe3722a3943020080daf2f3c
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMNL3 SATB1 CBFB ADD1	1.20e-04	185	61	4	a2cae8c657e4f4d121476798e424876f7e247973
ToppCell	10x5'-GI_large-bowel-Lymphocytic_B-Naive_B_cells\|GI_large-bowel / Manually curated celltypes from each tissue	CELSR1 KHDRBS2 HDX ADD1	1.20e-04	185	61	4	1c99373c123b5e0de40b47d9d885974a747b9839
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMNL3 SATB1 CBFB ADD1	1.20e-04	185	61	4	d50406a9a5b8d75110ba5985741aa2293950c543
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLFN13 SLFN5 SAMD3 ADD3	1.23e-04	186	61	4	71e87c4c755ab607689cb050f5a363cb520a0f53
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FMNL3 BYSL ZER1 TECPR1	1.23e-04	186	61	4	74c238759c5d3fd39127ec0060d0c2cb16b326d4
ToppCell	IPF-Myeloid-DC_Mature\|World / Disease state, Lineage and Cell class	CCNG2 LOXL2 KDM2B ATP11C	1.23e-04	186	61	4	d0d3953d9b199e0e792990b8551efb993393fe7e
ToppCell	facs-Skin-Anagen-3m-Epithelial-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT6B CELSR1 BYSL PPL	1.23e-04	186	61	4	9a7932d0a208f3997216bd21a72913cc82b59fc9
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CELSR1 LMO7 KHDRBS2 DNAH5	1.23e-04	186	61	4	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 SATB1 SAMD3 TECPR1	1.23e-04	186	61	4	4dce1484653bb266e2305cbb306fb11eaf7892e2
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN14 LMO7 AFDN SLFN5	1.23e-04	186	61	4	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
Disease	spastic quadriplegic cerebral palsy 3 (implicated_via_orthology)	ADD1 ADD3	1.22e-05	3	60	2	DOID:0081361 (implicated_via_orthology)
Disease	cerebral palsy (implicated_via_orthology)	ADD1 ADD3	1.81e-04	10	60	2	DOID:1969 (implicated_via_orthology)
Disease	C-C motif chemokine 16 measurement	SLFN11 SLFN5	2.65e-04	12	60	2	EFO_0008044
Disease	cutaneous melanoma, hair color	PTPN14 LMO7 ADD3	2.78e-04	62	60	3	EFO_0000389, EFO_0003924
Disease	primary ciliary dyskinesia (implicated_via_orthology)	DNAAF6 DNAH5	6.80e-04	19	60	2	DOID:9562 (implicated_via_orthology)
Disease	clopidogrel metabolite measurement	SLFN13 SLFN5	2.06e-03	33	60	2	EFO_0007966
Disease	Primary ciliary dyskinesia	DNAAF6 DNAH5	2.45e-03	36	60	2	cv:C0008780
Disease	cognition	KLHL2 ARHGAP18	2.45e-03	36	60	2	EFO_0003925
Disease	Primary Ciliary Dyskinesia	DNAAF6 DNAH5	4.14e-03	47	60	2	C4551720
Disease	neuroticism measurement, cognitive function measurement	DXO KLHL2 GTF3C1 PTPRU STAB1	5.85e-03	566	60	5	EFO_0007660, EFO_0008354
Disease	response to xenobiotic stimulus	CCNG2 CDH22 PHACTR3	6.10e-03	182	60	3	GO_0009410
Disease	coffee consumption measurement	DXO APOA4 ADD1	6.10e-03	182	60	3	EFO_0006781

Protein segments in the cluster

Peptide	Gene	Start	Entry
PTRDEIQAVERQYVI	ACO1	591	P21399
IRVEQQPDYRRQESR	AFDN	576	P55196
LDQIRREQYIPNEEF	NAT1	161	P18440
VEVGVLVRDYPDIRQ	EXOC3L2	301	Q2M3D2
DRINENDPEYIRERN	ADD3	26	Q9UEY8
LNVYLEQEERFQPRE	CCNG2	21	Q16589
PVFEQSEYRERVREN	CELSR1	351	Q9NYQ6
LQDPRRRDPQDDVYV	CDC14C	6	A4D256
RRQIINAIYEPTEEE	NAP1L2	151	Q9ULW6
LDQQVEEFRRRVEPY	APOA4	296	P06727
ELQQEEQARPEYEAR	ANO6	411	Q4KMQ2
RQDVSRYQRVDEALP	HECW2	796	Q9P2P5
VEVELEYQRRQVREP	DAAM2	891	Q86T65
QIDPEVIDQLREFYR	HS3ST2	336	Q9Y278
NEPREYIQILERRRA	NUP98	1291	P52948
QIDPAIQRVRAEERE	KRT6C	151	P48668
RDPYCRTQNLEIREV	HDX	251	Q7Z353
ISYVQDENRDPIRRR	INCENP	71	Q9NQS7
RNPYEGRVEVLVERN	LOXL2	441	Q9Y4K0
QIDPAIQRVRAEERE	KRT6B	151	P04259
VQQEVVRYEEEPGLR	PPL	1351	O60437
EQRQTPSREYVDLER	CBFB	76	Q13951
RAGEEERRQPQEEVV	LMO7	1316	Q8WWI1
RYQPRDEEVQERLDH	DXO	91	O77932
PISVYQVIVEEERAR	PTPRU	621	Q92729
TQRPIDRQRYDENED	KDM2B	41	Q8NHM5
ERLYNRTPEQVAEEE	DMAP1	231	Q9NPF5
QYERERQPLEELAAE	FMNL3	696	Q8IVF7
RHPEYQERCRQEVQE	CYP4F8	346	P98187
RHPEYQERCRQEVQE	CYP4F12	346	Q9HCS2
PDYNDEIRQEQLREL	KHDRBS2	161	Q5VWX1
PDLDRESQERYEVVI	CDH22	231	Q9UJ99
VREIPEYEIIFRQQV	DNAAF6	106	Q9NQM4
QYPREELTRVVRNAD	SLFN13	721	Q68D06
QLDPRVLEVYRGVRE	BYSL	176	Q13895
EVQINSAREEYRPVA	DNAH5	3806	Q8TE73
IFPRRTDEERQEIRQ	PHACTR3	421	Q96KR7
YVRRPIEDDEQVIRN	SAMD3	231	Q8N6K7
PLRELIDQYDVQRDD	MSTN	86	O14793
LRLRPRVFQEAVVDE	SMG7	371	Q92540
RSRIREVVPYEENRV	PTPN14	936	Q15678
QYPREELTRIVRNAD	SLFN11	721	Q7Z7L1
RRFQIINAEYEPTEE	NAP1L3	146	Q99457
PEAERDRIYQDERER	SATB1	436	Q01826
RQQELRYEQERRPAV	SAFB	696	Q15424
DEELPAQRYERDLVQ	SMURF1	366	Q9HCE7
EVPEQQRVVQERLRE	SPTBN5	1696	Q9NRC6
DRVDENNPEYLRERN	ADD1	26	P35611
IAPDDYERINRQLIE	ATP11C	606	Q8NB49
SIPEELEFQYRRVNE	ZER1	466	Q7Z7L7
EVEESSRPYLQEVQR	PROM2	406	Q8N271
SDVPIRRREEAYENQ	TECPR1	61	Q7Z6L1
REYEHVRRDLDPNEV	STK10	21	O94804
RIQRQDEEALRYITP	TBC1D16	86	Q8TBP0
RELPDQITQDCRYEV	STAB1	61	Q9NY15
LDSRQRLDYEREIQP	SPRY1	21	O43609
YQIPDVRDIFAQQRE	ARHGAP18	166	Q8N392
EEPRERPDLQLQDRY	GTF3C1	61	Q12789
EEPEKRRRQELERQY	TCHH	1156	Q07283
DQYPREEINRVVRNA	SLFN5	701	Q08AF3
PREYLVQRVEEEALV	KLHL2	251	O95198