Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inositol hexakisphosphate binding	XPR1 ITPR3	3.38e-05	4	48	2	GO:0000822
GeneOntologyCellularComponent	centrosome	CDKL5 PLEKHG6 RPS7 ANKRD62 CHD3 CCNJ CEP128 BIRC6 BICD1	5.50e-05	770	48	9	GO:0005813
GeneOntologyCellularComponent	microtubule organizing center	CDKL5 PLEKHG6 RPS7 ANKRD62 CHD3 CCNJ CEP128 BIRC6 BICD1	2.11e-04	919	48	9	GO:0005815
MousePheno	abnormal level of surface class II molecules	IL10 PRKDC IL2	2.38e-05	21	38	3	MP:0005042
MousePheno	abnormal antigen presentation via MHC class II	IL10 PRKDC IL2	3.61e-05	24	38	3	MP:0005041
MousePheno	rectal prolapse	IL10 MARK2 IL2	6.45e-05	29	38	3	MP:0000493
MousePheno	lymph node hyperplasia	PRKDC MARK2 IL2	9.56e-05	33	38	3	MP:0008102
MousePheno	salivary gland inflammation	PRKDC MARK2 IL2	1.46e-04	38	38	3	MP:0001870
MousePheno	increased plasma cell number	IL10 PRKDC IL2	1.71e-04	40	38	3	MP:0008097
MousePheno	abnormal rectum morphology	IL10 MARK2 IL2	2.12e-04	43	38	3	MP:0000492
Domain	ARM-type_fold	MON2 XPO5 PKP2 PRKDC ARMH3 SYMPK	2.21e-04	339	48	6	IPR016024
Domain	-	MON2 XPO5 PKP2 PRKDC SYMPK	2.56e-04	222	48	5	1.25.10.10
Domain	ARM-like	MON2 XPO5 PKP2 PRKDC SYMPK	6.27e-04	270	48	5	IPR011989
Domain	HEAT	PRKDC SYMPK	6.77e-03	48	48	2	PF02985
Domain	-	IL10 IL2	7.32e-03	50	48	2	1.20.1250.10
Domain	4_helix_cytokine_core	IL10 IL2	7.61e-03	51	48	2	IPR012351
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	KRT1 CHD3 PRKDC POTEJ CNOT1 IQGAP1 NUP205	1.40e-08	202	49	7	24639526
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	XPO5 RSL1D1 RPS7 PRKDC BIRC6 CNOT1 IQGAP1 NUP205 SYMPK ITPR3	2.16e-08	653	49	10	22586326
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	RSL1D1 RPS7 CHD3 PRKDC CDC73 MARK2 BIRC6 CNOT1 IQGAP1 NUP205	8.80e-08	759	49	10	35915203
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	XPO5 CHD3 PRKDC CDC73 MARK2 RNF17 CNOT1 IQGAP1 SYMPK	1.10e-07	582	49	9	20467437
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	KRT1 XPO5 PRKDC CNOT1 IQGAP1 ITPR3	4.05e-07	202	49	6	33005030
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	MON2 RSL1D1 PKP2 PRKDC BIRC6 CNOT1	1.50e-06	253	49	6	29911972
Pubmed	Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.	IL10 IL2	1.94e-06	2	49	2	2531194
Pubmed	Comparison of IL10 and IL2 genotypes of Turkish population with other populations.	IL10 IL2	1.94e-06	2	49	2	19284443
Pubmed	Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen.	IL10 IL2	1.94e-06	2	49	2	39394532
Pubmed	IL-2 overcomes the unresponsiveness but fails to reverse the regulatory function of antigen-induced T regulatory cells.	IL10 IL2	1.94e-06	2	49	2	15611254
Pubmed	Interleukin 2 and interleukin 10 function synergistically to promote CD8+ T cell cytotoxicity, which is suppressed by regulatory T cells in breast cancer.	IL10 IL2	1.94e-06	2	49	2	28274688
Pubmed	IL-10 deficiency promotes increased Borrelia burgdorferi clearance predominantly through enhanced innate immune responses.	IL10 PRKDC	1.94e-06	2	49	2	17082624
Pubmed	Intestinal epithelial cell up-regulation of LY6 molecules during colitis results in enhanced chemokine secretion.	IL10 PRKDC	1.94e-06	2	49	2	18322195
Pubmed	Interleukin-2 levels in exhaled breath condensates, asthma severity, and asthma control in nonallergic asthma.	IL10 IL2	1.94e-06	2	49	2	23998235
Pubmed	miRNAs and HIV: unforeseen determinants of host-pathogen interaction.	IL10 IL2	1.94e-06	2	49	2	23772625
Pubmed	Looking for immunological risk genotypes.	IL10 IL2	1.94e-06	2	49	2	15247007
Pubmed	DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes.	PRKDC IL2	1.94e-06	2	49	2	28750002
Pubmed	Association of Interleukin-2-330T/G and Interleukin-10-1082A/G Genetic Polymorphisms with B-Cell Non-Hodgkin Lymphoma in a Cohort of Egyptians.	IL10 IL2	1.94e-06	2	49	2	28713071
Pubmed	IL-10 and PRKDC polymorphisms are associated with glioma patient survival.	IL10 PRKDC	1.94e-06	2	49	2	27811370
Pubmed	IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi.	IL10 PRKDC	1.94e-06	2	49	2	9120288
Pubmed	Early versus Late Profiles of Inflammatory Cytokines after Mild Traumatic Brain Injury and Their Association with Neuropsychological Outcomes.	IL10 IL2	1.94e-06	2	49	2	32600167
Pubmed	Clinical significance of IL-2 and IL-10 gene polymorphisms and serum levels in patients with basal-cell carcinoma.	IL10 IL2	1.94e-06	2	49	2	26609634
Pubmed	IL-2 gene knockout affects T lymphocyte trafficking and the microglial response to regenerating facial motor neurons.	PRKDC IL2	1.94e-06	2	49	2	12507776
Pubmed	Rapid, comprehensive analysis of human cytokine mRNA and its application to the study of acute renal allograft rejection.	IL10 IL2	1.94e-06	2	49	2	7591871
Pubmed	The roles of IL-2 and IL-10 enhance anti-CD45RBmAb immune inhibition in allograft skin.	IL10 IL2	1.94e-06	2	49	2	25550088
Pubmed	RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.	KRT1 RSL1D1 RPS7 CHD3 PRKDC CDC73 IQGAP1	2.14e-06	425	49	7	21081503
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	XPO5 RPS7 PRKDC CDC73 CNOT1 IQGAP1 NUP205 SYMPK	2.85e-06	638	49	8	33239621
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	KRT1 XPO5 RSL1D1 RPS7 CHD3 PRKDC CNOT1 NUP205	2.95e-06	641	49	8	36057605
Pubmed	Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment.	KRT1 XPO5 RSL1D1 RPS7 PRKDC IQGAP1 NUP205	5.51e-06	491	49	7	22623428
Pubmed	Peripheral education of the immune system by colonic commensal microbiota.	IL10 IL2	5.83e-06	3	49	2	21937990
Pubmed	Key genes involved in the immune response are generally not associated with intraprostatic inflammation in men without a prostate cancer diagnosis: Results from the prostate cancer prevention trial.	IL10 IL2	5.83e-06	3	49	2	26771888
Pubmed	Characterization of the murine immunological signaling network with phosphospecific flow cytometry.	IL10 IL2	5.83e-06	3	49	2	16081807
Pubmed	Alveolar macrophages in neonatal mice are inherently unresponsive to Pneumocystis murina infection.	IL10 PRKDC	5.83e-06	3	49	2	22665378
Pubmed	Cytokine polymorphic analyses indicate ethnic differences in the allelic distribution of interleukin-2 and interleukin-6.	IL10 IL2	5.83e-06	3	49	2	11544437
Pubmed	Local expression of vaginal Th1 and Th2 cytokines in murine vaginal candidiasis under different immunity conditions.	IL10 IL2	5.83e-06	3	49	2	18704316
Pubmed	The genes encoding cytokines IL-2, IL-10 and IL-12B are primary 1alpha,25(OH)2D3 target genes.	IL10 IL2	5.83e-06	3	49	2	20236616
Pubmed	The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice.	IL10 PRKDC	5.83e-06	3	49	2	11390498
Pubmed	Complement receptor type 1 (CR1, CD35) is a potent inhibitor of B-cell functions in rheumatoid arthritis patients.	IL10 IL2	5.83e-06	3	49	2	22962438
Pubmed	Evaluation of IL-2, IL-4 and IL-10 levels in patients with giardiosis.	IL10 IL2	5.83e-06	3	49	2	35130415
Pubmed	Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate.	PRKDC IL2	5.83e-06	3	49	2	17947634
Pubmed	Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes.	IL10 PRKDC	5.83e-06	3	49	2	16549598
Pubmed	Role of genetically determined production of immunoregulatory cytokines in immunopathogenesis of chronic viral hepatitides.	IL10 IL2	5.83e-06	3	49	2	18239807
Pubmed	Genetic polymorphisms in IL-2, IL-10, TGF-β1, and IL-2RB and acute rejection in renal transplant patients.	IL10 IL2	5.83e-06	3	49	2	24579958
Pubmed	Th2 cell therapy of established acute graft-versus-host disease requires IL-4 and IL-10 and is abrogated by IL-2 or host-type antigen-presenting cells.	IL10 IL2	5.83e-06	3	49	2	18721759
Pubmed	gp41 envelope protein of human immunodeficiency virus induces interleukin (IL)-10 in monocytes, but not in B, T, or NK cells, leading to reduced IL-2 and interferon-gamma production.	IL10 IL2	5.83e-06	3	49	2	9534962
Pubmed	Evaluation of IL-2, IL-10, IL-17 and IP-10 as potent discriminative markers for active tuberculosis among pulmonary tuberculosis suspects.	IL10 IL2	5.83e-06	3	49	2	27450011
Pubmed	Protective role of TNF-α, IL-10 and IL-2 in mice infected with the Oshima strain of Tick-borne encephalitis virus.	IL10 IL2	5.83e-06	3	49	2	24938868
Pubmed	A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetes.	IL10 PRKDC	5.83e-06	3	49	2	11120869
Pubmed	IL-2 activation of STAT5 enhances production of IL-10 from human cytotoxic regulatory T cells, HOZOT.	IL10 IL2	5.83e-06	3	49	2	18023521
Pubmed	CD4+ Foxp3+ regulatory T cells mediate Toxoplasma gondii-induced T-cell suppression through an IL-2-related mechanism but independently of IL-10.	IL10 IL2	5.83e-06	3	49	2	21905022
Pubmed	Hepatitis C virus and disrupted interferon signaling promote lymphoproliferation via type II CD95 and interleukins.	IL10 IL2	5.83e-06	3	49	2	19362089
Pubmed	Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota.	PRKDC IL2	5.83e-06	3	49	2	23670188
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	KRT1 XPO5 RSL1D1 RPS7 PRKDC CNOT1 IQGAP1 NUP205	6.06e-06	707	49	8	19738201
Pubmed	IL-2, IL-10, IL-15 and TNF are key regulators of murine T-cell lymphoma growth.	IL10 IL2	1.16e-05	4	49	2	12964046
Pubmed	Plasmodium berghei ANKA infection increases Foxp3, IL-10 and IL-2 in CXCL-10 deficient C57BL/6 mice.	IL10 IL2	1.16e-05	4	49	2	21439091
Pubmed	Interaction effects among IFN-γ+874, IL-2-330, IL-10-1082, IL-10-592 and IL-4-589 polymorphisms on the clinical progression of subjects infected with hepatitis B virus and/or hepatitis C virus: a retrospective nested case-control study.	IL10 IL2	1.16e-05	4	49	2	28838891
Pubmed	Role of toll-like receptors in spontaneous commensal-dependent colitis.	IL10 IL2	1.16e-05	4	49	2	16879997
Pubmed	Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency.	IL10 IL2	1.16e-05	4	49	2	9620592
Pubmed	Increased mRNA expression of key cytokines among suspected cases of Pneumocystis jirovecii infection.	IL10 IL2	1.16e-05	4	49	2	33413198
Pubmed	Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation.	IL10 PRKDC	1.16e-05	4	49	2	18684934
Pubmed	Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages.	IL10 PRKDC	1.16e-05	4	49	2	22053215
Pubmed	Toll-like receptor ligand activation of murine bone marrow-derived dendritic cells.	IL10 IL2	1.16e-05	4	49	2	18778283
Pubmed	Evaluation of IL-2, IL-6, IL-8 and IL-10 in Malignant Melanoma Diagnostics.	IL10 IL2	1.16e-05	4	49	2	26026122
Pubmed	Renovascular disease is associated with low producer genotypes of the anti-inflammatory cytokine interleukin-10.	IL10 IL2	1.16e-05	4	49	2	15104679
Pubmed	Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers.	IL10 IL2	1.16e-05	4	49	2	12391195
Pubmed	Differential Expression Profile of Immunological Cytokines in Local Ovary in Patients with Polycystic Ovarian Syndrome: analysis by Flow Cytometry.	IL10 IL2	1.16e-05	4	49	2	26751822
Pubmed	Differential cytokine expression in maternal blood and placenta during murine gestation.	IL10 IL2	1.16e-05	4	49	2	8133052
Pubmed	Polymorphisms of some cytokines and chronic hepatitis B and C virus infection.	IL10 IL2	1.16e-05	4	49	2	19938203
Pubmed	IL-2 and IL-27 synergistically promote growth and invasion of endometriotic stromal cells by maintaining the balance of IFN-γ and IL-10 in endometriosis.	IL10 IL2	1.16e-05	4	49	2	31869309
Pubmed	Using cytometric bead arrays to detect cytokines in the serum of patients with different types of pulmonary tuberculosis.	IL10 IL2	1.16e-05	4	49	2	31012357
Pubmed	Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome.	IL10 IL2	1.16e-05	4	49	2	17052299
Pubmed	Inflammatory Response and Activation of Coagulation after COVID-19 Infection.	IL10 IL2	1.16e-05	4	49	2	37112918
Pubmed	Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance.	PRKDC IL2	1.16e-05	4	49	2	23791643
Pubmed	Association of IL2, TNFA, IL4 and IL10 Promoter Gene Polymorphisms with the Rate of Progression of the HIV Infection.	IL10 IL2	1.16e-05	4	49	2	12687247
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	CDKL5 KRT1 RSL1D1 RPS7 PKP2 PRKDC BIRC6 XPR1	1.20e-05	777	49	8	35844135
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	KRT1 RSL1D1 RPS7 PKP2 CNOT1 ITPR3	1.43e-05	375	49	6	32788342
Pubmed	Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry.	IL10 IL2	1.94e-05	5	49	2	16081806
Pubmed	Expression of Th1/Th2 cytokine mRNA in peritoneal exudative polymorphonuclear neutrophils and their effects on mononuclear cell Th1/Th2 cytokine production in MRL-lpr/lpr mice.	IL10 IL2	1.94e-05	5	49	2	9824514
Pubmed	T-helper 1, T-helper 2, and T-regulatory cytokines gene polymorphisms in irritable bowel syndrome.	IL10 IL2	1.94e-05	5	49	2	20177758
Pubmed	Frequency of cytokine polymorphisms in populations from western Europe, Africa, Asia, the Middle East and South America.	IL10 IL2	1.94e-05	5	49	2	12392859
Pubmed	IL-10, TGF-beta, IL-2, IL-12, and IFN-gamma cytokine gene polymorphisms in asthma.	IL10 IL2	1.94e-05	5	49	2	18972297
Pubmed	A pro-inflammatory genotype predisposes to Barrett's esophagus.	IL10 IL2	1.94e-05	5	49	2	18192685
Pubmed	Concentration of IL-2, IL-6, IL-8, IL-10 and TNF-alpha in children with acute lymphoblastic leukemia after cessation of chemotherapy.	IL10 IL2	1.94e-05	5	49	2	15152368
Pubmed	Frequency of cytokine gene promoter polymorphisms in the Northern Ireland cystic fibrosis population.	IL10 IL2	1.94e-05	5	49	2	17336597
Pubmed	Frequencies of the common promoter polymorphisms in cytokine genes in a Polish population.	IL10 IL2	1.94e-05	5	49	2	16164695
Pubmed	Ability of epistatic interactions of cytokine single-nucleotide polymorphisms to predict susceptibility to disease subsets in systemic sclerosis patients.	IL10 IL2	1.94e-05	5	49	2	18576303
Pubmed	The impact of the IL-1β, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype.	IL10 IL2	1.94e-05	5	49	2	26654556
Pubmed	Regulation of type 17 helper T-cell function by nitric oxide during inflammation.	IL10 IL2	1.94e-05	5	49	2	21576463
Pubmed	c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells.	IL10 IL2	1.94e-05	5	49	2	29662170
Pubmed	Expanding antigen-specific regulatory networks to treat autoimmunity.	IL10 PRKDC	1.94e-05	5	49	2	26886799
Pubmed	Associations of IL-2 and IL-4 gene polymorphisms with psoriasis in the Korean population.	IL10 IL2	1.94e-05	5	49	2	17714919
Pubmed	Aggressive non-Hodgkin's lymphoma: concomitant evaluation of interleukin-2, soluble interleukin-2 receptor, interleukin-4, interleukin-6, interleukin-10 and correlation with outcome.	IL10 IL2	1.94e-05	5	49	2	16690518
Pubmed	The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression.	IL10 IL2	1.94e-05	5	49	2	9184696
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	KRT1 RSL1D1 RPS7 CHD3 PRKDC CDC73 IQGAP1	2.12e-05	605	49	7	28977666
Pubmed	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.	XPO5 RSL1D1 PRKDC ITGA3	2.37e-05	118	49	4	27377895
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	MON2 XPO5 PRKDC IQGAP1	2.53e-05	120	49	4	27320910
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	KRT1 RSL1D1 RPS7 CHD3 PRKDC POTEJ RNF17 CEP128 IQGAP1 NUP205	2.73e-05	1442	49	10	35575683
Pubmed	[Pseudomonas aeruginosa recombinant proteins: effect on mice cytokine profile].	IL10 IL2	2.91e-05	6	49	2	24605680
Pubmed	Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells.	IL10 IL2	2.91e-05	6	49	2	23918371
Pubmed	Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African-American renal transplant patients.	IL10 IL2	2.91e-05	6	49	2	12727482
Interaction	CIT interactions	XPO5 DYNC2H1 RSL1D1 RPS7 PKP2 CHD3 PRKDC CDC73 POTEJ BIRC6 IQGAP1 BICD1 NUP205 SYMPK ITPR3	7.55e-07	1450	48	15	int:CIT
Interaction	EFNA4 interactions	KRT1 XPO5 RPS7 PRKDC ITGA3 SYMPK XPR1	1.47e-06	239	48	7	int:EFNA4
Interaction	C19orf38 interactions	MON2 XPO5 DYNC2H1 PRKDC XPR1	1.86e-06	86	48	5	int:C19orf38
Interaction	LGR4 interactions	KRT1 CHD3 PRKDC POTEJ CNOT1 IQGAP1 NUP205	2.71e-06	262	48	7	int:LGR4
Interaction	KRT18 interactions	KRT1 XPO5 PKP2 CEP128 BIRC6 CNOT1 NUP205 ITPR3	5.95e-06	419	48	8	int:KRT18
Interaction	SIRT7 interactions	XPO5 RSL1D1 RPS7 PRKDC BIRC6 CNOT1 IQGAP1 NUP205 SYMPK ITPR3	8.12e-06	744	48	10	int:SIRT7
Interaction	POU5F1 interactions	KRT1 RSL1D1 RPS7 CHD3 PRKDC CDC73 CNOT1 SYMPK ITPR3	8.28e-06	584	48	9	int:POU5F1
Interaction	LRRC31 interactions	KRT1 XPO5 PRKDC CNOT1 IQGAP1 ITPR3	8.85e-06	205	48	6	int:LRRC31
Interaction	EED interactions	KRT1 XPO5 RSL1D1 RPS7 PKP2 CHD3 PRKDC MARK2 BIRC6 CNOT1 IQGAP1 NUP205 SYMPK	2.26e-05	1445	48	13	int:EED
Interaction	FN1 interactions	KRT1 XPO5 RSL1D1 RPS7 PRKDC ITGA3 CNOT1 IQGAP1 NUP205 SYMPK	2.52e-05	848	48	10	int:FN1
Interaction	PEX3 interactions	MON2 PKP2 BIRC6 NUP205 ITPR3	5.29e-05	171	48	5	int:PEX3
Interaction	CLIP1 interactions	CHD3 BIRC6 IQGAP1 BICD1 NUP205	7.29e-05	183	48	5	int:CLIP1
Interaction	HECTD1 interactions	RSL1D1 RPS7 CHD3 PRKDC CDC73 MARK2 BIRC6 CNOT1 IQGAP1 NUP205	8.84e-05	984	48	10	int:HECTD1
Interaction	VIM interactions	KRT1 RPS7 PKP2 CHD3 PRKDC CDC73 CEP128 IQGAP1 BICD1	1.01e-04	804	48	9	int:VIM
Interaction	PXN interactions	MON2 PLEKHH2 BIRC6 CNOT1 IQGAP1 BICD1	1.35e-04	334	48	6	int:PXN
Interaction	MS4A4A interactions	MON2 XPO5 PRKDC	1.36e-04	42	48	3	int:MS4A4A
Interaction	CDC5L interactions	XPO5 CHD3 PRKDC CDC73 MARK2 RNF17 CNOT1 IQGAP1 SYMPK	1.61e-04	855	48	9	int:CDC5L
Interaction	MECOM interactions	RPS7 CHD3 PRKDC CEP128 IQGAP1 NUP205	1.97e-04	358	48	6	int:MECOM
Interaction	RANBP2 interactions	CDKL5 PRKDC CDC73 BICD1 NUP205 ITPR3	2.06e-04	361	48	6	int:RANBP2
Interaction	WDR5 interactions	KRT1 RSL1D1 RPS7 CHD3 PRKDC IQGAP1 HELB NUP205 SYMPK ITPR3	2.22e-04	1101	48	10	int:WDR5
Interaction	NFATC3 interactions	IL2 CEP128 BICD1	2.30e-04	50	48	3	int:NFATC3
Interaction	ACE2 interactions	KRT1 XPO5 RSL1D1 RPS7 CHD3 PRKDC ITGA3 POTEJ CNOT1 NUP205	2.30e-04	1106	48	10	int:ACE2
Interaction	RHOV interactions	XPO5 MARK2 IQGAP1 NUP205 XPR1	2.74e-04	243	48	5	int:RHOV
Interaction	ITGA4 interactions	KRT1 XPO5 RSL1D1 RPS7 PRKDC IQGAP1 NUP205	2.93e-04	547	48	7	int:ITGA4
Interaction	MTNR1B interactions	MON2 DYNC2H1 PRKDC ITPR3	2.98e-04	135	48	4	int:MTNR1B
Interaction	APC interactions	CDKL5 RPS7 PKP2 MARK2 CEP128 IQGAP1	3.08e-04	389	48	6	int:APC
GeneFamily	Endogenous ligands\|Interleukins	IL10 IL2	2.01e-03	43	28	2	601
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4/8-lo-Trm_Tgd\|lymph-node_spleen / Manually curated celltypes from each tissue	DYNC2H1 ZSCAN30 PLEKHH2 NUP205 SYMPK	7.67e-07	155	49	5	b0e456c4915076e1d38282e116a6eb3230ae80dc
Drug	2,3-bis(palmitoyloxy)-2-propyl-1-palmitoylcysteine	IL10 IL2	1.25e-05	3	47	2	ctd:C069172
Drug	Phe-Leu boronic acid	IL10 IL2	1.25e-05	3	47	2	ctd:C433028
Drug	interferon alfa-n1	IL10 IL2	1.25e-05	3	47	2	ctd:C554150
Drug	fTCP	IL10 IL2	2.50e-05	4	47	2	CID000124573
Drug	BTS 71	IL10 IL2	2.50e-05	4	47	2	CID000061338
Drug	tucaresol	IL10 PRKDC IL2	2.60e-05	28	47	3	CID000055223
Drug	Alkalies	IL10 IL2	4.15e-05	5	47	2	ctd:D000468
Drug	mineral trioxide aggregate	IL10 IL2	4.15e-05	5	47	2	ctd:C086631
Drug	4-tolyl isocyanate	IL10 IL2	4.15e-05	5	47	2	ctd:C025637
Drug	Sialokinin I	IL10 IL2	4.15e-05	5	47	2	CID000132956
Drug	Sialokinin Ii	IL10 IL2	4.15e-05	5	47	2	CID000132957
Drug	Glat copolymer	IL10 IL2 IQGAP1	5.15e-05	35	47	3	CID000065370
Drug	Ethisterone [434-03-7]; Down 200; 12.8uM; MCF7; HT_HG-U133A	MON2 CDADC1 IL2 BICD1 SYMPK	5.26e-05	197	47	5	2326_DN
Drug	8-hydroxyeicosatetraenoic acid	IL10 KRT1	6.22e-05	6	47	2	ctd:C047628
Drug	glucan phosphate	IL10 IL2	6.22e-05	6	47	2	ctd:C480175
Drug	monocyte locomotion inhibitory factor	IL10 IL2	6.22e-05	6	47	2	ctd:C430647
Drug	Benzocaine	IL10 IL2	6.22e-05	6	47	2	ctd:D001566
Drug	Minerals	IL10 IL2	6.22e-05	6	47	2	ctd:D008903
Drug	scropolioside A	IL10 IL2	6.22e-05	6	47	2	CID006449923
Drug	artelastin	IL10 IL2	8.70e-05	7	47	2	CID000399488
Drug	Mitogens	IL10 IL2	8.70e-05	7	47	2	ctd:D008934
Drug	T8 0	KRT1 XPR1	8.70e-05	7	47	2	CID000446897
Drug	Oligodeoxyribonucleotides	IL10 IL2	8.70e-05	7	47	2	ctd:D009838
Drug	9 mM of H	IL2 ITPR3	1.16e-04	8	47	2	CID000130464
Drug	AC1O5WSZ	IL10 IL2	1.16e-04	8	47	2	CID006439331
Drug	seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide	IL10 IL2	1.16e-04	8	47	2	ctd:C112356
Drug	Amb a I protein, Ambrosia artemisiifolia	IL10 IL2	1.16e-04	8	47	2	ctd:C026967
Drug	VIVIT peptide	IL10 IL2	1.16e-04	8	47	2	ctd:C121611
Drug	AC1N9TEG	CHGB IL2 IQGAP1 ITPR3	1.25e-04	124	47	4	CID000000478
Drug	dechlorane 602	IL10 IL2	1.49e-04	9	47	2	ctd:C556733
Drug	DAPM	MED7 CNOT1 SYMPK XPR1	1.73e-04	135	47	4	CID000007577
Drug	oridonin	IL10 IL2	1.86e-04	10	47	2	ctd:C011959
Disease	bacterial infectious disease (is_marker_for)	IL10 IL2	7.13e-06	3	46	2	DOID:104 (is_marker_for)
Disease	open-angle glaucoma (is_marker_for)	IL10 IL2	7.13e-06	3	46	2	DOID:1067 (is_marker_for)
Disease	herpes zoster (is_marker_for)	IL10 IL2	1.42e-05	4	46	2	DOID:8536 (is_marker_for)
Disease	tongue squamous cell carcinoma (biomarker_via_orthology)	IL10 IL2	3.55e-05	6	46	2	DOID:0050865 (biomarker_via_orthology)
Disease	Entamoeba histolytica Infection	IL10 IL2	3.55e-05	6	46	2	C4316791
Disease	Entamoebiasis	IL10 IL2	3.55e-05	6	46	2	C0014324
Disease	aggressive periodontitis (is_marker_for)	IL10 IL2	3.55e-05	6	46	2	DOID:1474 (is_marker_for)
Disease	Graves ophthalmopathy (is_implicated_in)	IL10 IL2	1.06e-04	10	46	2	DOID:0081120 (is_implicated_in)
Disease	uveitis (is_marker_for)	IL10 IL2	1.83e-04	13	46	2	DOID:13141 (is_marker_for)
Disease	autoimmune thrombocytopenic purpura (is_implicated_in)	IL10 IL2	2.46e-04	15	46	2	DOID:8924 (is_implicated_in)
Disease	Autoimmune Chronic Hepatitis	IL10 IL2	3.19e-04	17	46	2	C0241910
Disease	graft-versus-host disease (is_implicated_in)	IL10 IL2	3.19e-04	17	46	2	DOID:0081267 (is_implicated_in)
Disease	lung disease (is_marker_for)	IL10 IL2	5.38e-04	22	46	2	DOID:850 (is_marker_for)
Disease	inflammatory bowel disease (implicated_via_orthology)	IL10 IL2	6.97e-04	25	46	2	DOID:0050589 (implicated_via_orthology)
Disease	anogenital venereal wart (is_marker_for)	IL10 IL2	7.55e-04	26	46	2	DOID:11168 (is_marker_for)
Disease	Nephrotic Syndrome	XPO5 IL2	8.14e-04	27	46	2	C0027726
Disease	oral squamous cell carcinoma (is_implicated_in)	IL10 IL2	8.76e-04	28	46	2	DOID:0050866 (is_implicated_in)
Disease	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	XPO5 NUP205	1.01e-03	30	46	2	C1868672
Disease	Bright Disease	IL10 IL2	1.07e-03	31	46	2	C1704377
Disease	Adult T-Cell Lymphoma/Leukemia	IL10 IL2	1.07e-03	31	46	2	C0023493
Disease	Glomerulonephritis	IL10 IL2	1.07e-03	31	46	2	C0017658
Disease	Brain Tumor, Primary	IL2 IQGAP1	1.22e-03	33	46	2	C0750974
Disease	Primary malignant neoplasm of brain	IL2 IQGAP1	1.22e-03	33	46	2	C0750979
Disease	Recurrent Brain Neoplasm	IL2 IQGAP1	1.22e-03	33	46	2	C0750977
Disease	Neoplasms, Intracranial	IL2 IQGAP1	1.22e-03	33	46	2	C1527390
Disease	Benign neoplasm of brain, unspecified	IL2 IQGAP1	1.22e-03	33	46	2	C0496899
Disease	age at menopause	PRKDC CCNJ BIRC6 HELB	1.25e-03	302	46	4	EFO_0004704
Disease	hepatitis C (is_marker_for)	IL10 IL2	1.37e-03	35	46	2	DOID:1883 (is_marker_for)
Disease	Behcet's disease (is_implicated_in)	IL10 IL2	1.45e-03	36	46	2	DOID:13241 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MEEARLQLKDQLLCL	CEP128	806	Q6ZU80
DQLMFDLLKLVNILV	BIRC6	2916	Q9NR09
LNTLLRMAIQQKLAL	BICD1	776	Q96G01
LITMLNAKDLLQDLK	CDC73	371	Q6P1J9
VLTKQNLLHMELLLL	CCNJ	121	Q5T5M9
DALNKQLLLEAMLEI	ANKRD62	866	A6NC57
INLLKFLMSNETVLL	ARMH3	501	Q5T2E6
NLRQNMKDLILLLAT	CDADC1	271	Q9BWV3
LENDLNLMDIKIGLL	IQGAP1	906	P46940
MDLVLQLKDNASKLL	ITPR3	1986	Q14573
QLKDNASKLLLALME	ITPR3	1991	Q14573
ALLNLTLQKENLFMD	NUP205	851	Q92621
QMKDQLDNLLLKESL	IL10	56	P22301
LNMSILINFLDLLDI	MED7	81	O43513
ALKAQENLLLLVSMA	FHIP2B	261	Q86V87
QKLELLLMDNLRDKL	ITGA3	551	P26006
QELMNTKLALDLEIA	KRT1	466	P04264
LELMELPFELSNLKQ	LRRC2	201	Q9BYS8
LWQLMENSLEELKLL	MON2	111	Q7Z3U7
LNKDLALEMAALLSQ	PLEKHH2	1251	Q8IVE3
KIMTDLLAAGLLNLQ	PLEKHG6	181	Q3KR16
NDLALEMKKTLEQLL	DYNC2H1	1501	Q8NCM8
QLQLEHLLLDLQMIL	IL2	31	P60568
ELQELLSKLMDAFNL	DYTN	526	A2CJ06
LHKVLNQLEELLSDM	CHD3	1861	Q12873
MILLNNSERLLALFK	GLYATL1B	1	A0A0U1RQE8
LKAENLLLDADMNIK	MARK2	176	Q7KZI7
LFLQMNLLRKIENLE	DNAAF1	156	Q8NEP3
ELKMDQALLLIHNEL	HGSNAT	76	Q68CP4
MELENIVANSLLLKA	GRK4	1	P32298
LNSVLLDLMKNLLKL	CDKL5	266	O76039
ALLQLNEFLLMVILQ	DIPK1A	196	Q5T7M9
LENLAAMDLELQKIA	CHGB	656	P05060
ESLLQLMTDLEKNAL	HELB	281	Q8NG08
ALLELEMNSDLKAQL	RPS7	26	P62081
LLDSQLHNLIMLQLT	OR7E24	171	Q6IFN5
DNLLKALQLNELTMD	POTEJ	651	P0CG39
LDVAQDLKALSMLLN	CNOT1	561	A5YKK6
LLTENLLNSLEEKMI	RNF17	936	Q9BXT8
NELKAEFLILLHMLQ	SPATA4	206	Q8NEY3
LADQLNSLSVILMDL	XPR1	396	Q9UBH6
QILELLMLEQFLAIL	ZSCAN30	86	Q86W11
LLLNENESLFLMVVL	RSL1D1	56	O76021
SLLEELKMNKIQLQL	SMC1B	211	Q8NDV3
KQLLSNELLLTQMEK	XPO5	631	Q9HAV4
LLLKLIANLNMLLRD	SYMPK	106	Q92797
LLKNLDLAVLELMQS	PRKDC	1571	P78527
SNDKLKNLMITEALL	PKP2	511	Q99959
ILLQEKRNCLLMQLE	WWC3	326	Q9ULE0
GQEVLMNLLLALLLD	PLPP7	141	Q8NBV4