Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR52L2P OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1 OR10T2 OR10R2	4.26e-14	431	89	19	GO:0004984
GeneOntologyMolecularFunction	odorant binding	OR12D3 OR5M9 OR9G1 OR5B12 OR13A1 OR10K1 OR10K2 OR5H2 OR6K3 OR10T2 OR10R2	1.07e-11	127	89	11	GO:0005549
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 GPR22 OR1I1 OR5B12 OR52L2P OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 TAS2R20 OR10S1 OR10T2 OR10R2 RHO	3.04e-11	884	89	22	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR1N1 OR51G2 OR12D3 ANTXRL OR5M9 EFNA3 OR9A4 OR9G1 GPR22 OR1I1 OR5B12 OR52L2P OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 TAS2R20 OR10S1 IL1RL2 OR10T2 OR10R2 RHO	5.92e-10	1353	89	25	GO:0004888
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR52L2P OR51I2 OR13A1 OR52N5 OR10K1 DRGX OR10K2 OR5H2 OR6K3 TAS2R20 OR10S1 OR10T2 OR10R2	3.43e-15	524	87	21	GO:0009593
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR52L2P OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 TAS2R20 OR10S1 OR10T2 OR10R2	1.00e-14	485	87	20	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR52L2P OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1 OR10T2 OR10R2	1.61e-14	432	87	19	GO:0050911
GeneOntologyBiologicalProcess	detection of stimulus	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR52L2P OR51I2 OR13A1 OR52N5 OR10K1 DRGX OR10K2 OR5H2 OR6K3 TAS2R20 OR10S1 PKDREJ OR10T2 OR10R2 RHO	1.80e-14	722	87	23	GO:0051606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR52L2P OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 TAS2R20 OR10S1 OR10T2 OR10R2 RHO	2.70e-14	582	87	21	GO:0050906
GeneOntologyBiologicalProcess	sensory perception of smell	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR52L2P OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1 OR10T2 OR10R2	6.03e-14	465	87	19	GO:0007608
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR52L2P OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 TAS2R20 OR10S1 OR10T2 OR10R2	9.58e-14	547	87	20	GO:0007606
GeneOntologyBiologicalProcess	sensory perception	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR52L2P OR51I2 OR13A1 OR52N5 OR10K1 DRGX OR10K2 OR5H2 OR6K3 TAS2R20 OR10S1 BBS9 OR10T2 OR10R2 RHO	6.09e-11	1072	87	23	GO:0007600
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 GPR22 OR1I1 OR5B12 OR52L2P OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 TAS2R20 OR10S1 OR10T2 OR10R2 ADCY6 RGS7 RHO	1.88e-09	1395	87	24	GO:0007186
GeneOntologyBiologicalProcess	multicellular organismal-level chemical homeostasis	ABCA3 IREB2 AQP3 ADCY6 RHD	3.94e-05	90	87	5	GO:0140962
GeneOntologyBiologicalProcess	heme metabolic process	SRRD SLCO1B3 IREB2 SLCO1B1	7.95e-05	54	87	4	GO:0042168
GeneOntologyBiologicalProcess	porphyrin-containing compound metabolic process	SRRD SLCO1B3 IREB2 SLCO1B1	1.45e-04	63	87	4	GO:0006778
GeneOntologyBiologicalProcess	tetrapyrrole metabolic process	SRRD SLCO1B3 IREB2 SLCO1B1	2.57e-04	73	87	4	GO:0033013
HumanPheno	Bilirubinuria	SLCO1B3 SLCO1B1	2.31e-05	2	25	2	HP:0031811
Domain	Olfact_rcpt	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1 OR10T2 OR10R2	2.27e-13	393	87	18	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 GPR22 OR1I1 OR5B12 OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1 OR10T2 OR10R2 RHO	2.35e-11	670	87	20	IPR017452
Domain	7tm_1	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 GPR22 OR1I1 OR5B12 OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1 OR10T2 OR10R2 RHO	2.83e-11	677	87	20	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 GPR22 OR1I1 OR5B12 OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1 OR10T2 OR10R2 RHO	3.49e-11	685	87	20	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 GPR22 OR1I1 OR5B12 OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1 OR10T2 OR10R2 RHO	4.07e-11	691	87	20	PS50262
Domain	GPCR_Rhodpsn	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 GPR22 OR1I1 OR5B12 OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1 OR10T2 OR10R2 RHO	4.18e-11	692	87	20	IPR000276
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1 OR10T2 OR10R2	3.55e-14	389	62	18	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1 OR10T2 OR10R2	1.17e-13	417	62	18	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 TAS2R20 OR10S1 OR10T2 OR10R2 RHO	1.41e-12	636	62	20	M41834
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1	4.53e-16	340	89	16	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1	4.53e-16	340	89	16	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1	5.20e-16	343	89	16	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR1I1 OR5B12 OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1	5.96e-16	346	89	16	14611657
Pubmed	The human olfactory receptor gene family.	OR1N1 OR51G2 OR12D3 OR5M9 OR9A4 OR9G1 OR5B12 OR52L2P OR51I2 OR13A1 OR52N5 OR10K1 OR10K2 OR5H2 OR6K3 OR10S1 OR10T2 OR10R2	2.35e-15	541	89	18	14983052
Pubmed	Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	18314419
Pubmed	OATP 1B1/1B3 expression in hepatocellular carcinomas treated with orthotopic liver transplantation.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	21691816
Pubmed	Structure of human drug transporters OATP1B1 and OATP1B3.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	37723174
Pubmed	Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	24855184
Pubmed	Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity - The hyperbilirubinemia use case.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	28063966
Pubmed	Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	26474710
Pubmed	Effects of anthocyans on the expression of organic anion transporting polypeptides (SLCOs/OATPs) in primary human hepatocytes.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	25578040
Pubmed	Effects of Rifampin, a potent inducer of drug-metabolizing enzymes and an inhibitor of OATP1B1/3 transport, on the single dose pharmacokinetics of anacetrapib.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	23670789
Pubmed	Long-lasting inhibitory effects of cyclosporin A, but not tacrolimus, on OATP1B1- and OATP1B3-mediated uptake.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	22240838
Pubmed	Prediction of organic anion-transporting polypeptide 1B1- and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	24989890
Pubmed	Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	17496208
Pubmed	Rotor Syndrome	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	23236639
Pubmed	Modulation of transporter activity of OATP1B1 and OATP1B3 by the major active components of Radix Ophiopogonis.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	29944058
Pubmed	Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	17412826
Pubmed	SLCO1B1 and SLCO1B3 genetic mutations in Taiwanese patients with Rotor syndrome.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	36964102
Pubmed	Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	27098745
Pubmed	Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	24740327
Pubmed	Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	21719246
Pubmed	Organic anion transporting polypeptide 1B1 (OATP1B1) and OATP1B3: genetic variability and haplotype analysis in white Canadians.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	20877131
Pubmed	Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	23340295
Pubmed	Relationship between SLCO1B3 and ABCA3 polymorphisms and imatinib response in chronic myeloid leukemia patients.	ABCA3 SLCO1B3	6.48e-06	2	89	2	25056761
Pubmed	Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	16534140
Pubmed	UGT-dependent regioselective glucuronidation of ursodeoxycholic acid and obeticholic acid and selective transport of the consequent acyl glucuronides by OATP1B1 and 1B3.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	31299240
Pubmed	Further Studies to Support the Use of Coproporphyrin I and III as Novel Clinical Biomarkers for Evaluating the Potential for Organic Anion Transporting Polypeptide 1B1 and OATP1B3 Inhibition.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	29777022
Pubmed	Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	26191226
Pubmed	In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	23886114
Pubmed	OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	21787759
Pubmed	Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	18321482
Pubmed	Visualization of hepatic uptake transporter function in healthy subjects by using gadoxetic acid-enhanced MR imaging.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	22771883
Pubmed	Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	24194513
Pubmed	Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the hepatobiliary transport of telmisartan acylglucuronide.	SLCO1B3 SLCO1B1	6.48e-06	2	89	2	18180273
Pubmed	Preincubation With Everolimus and Sirolimus Reduces Organic Anion-Transporting Polypeptide (OATP)1B1- and 1B3-Mediated Transport Independently of mTOR Kinase Inhibition: Implication in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	31047942
Pubmed	Multiple Genetic Modifiers of Bilirubin Metabolism Involvement in Significant Neonatal Hyperbilirubinemia in Patients of Chinese Descent.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	26146841
Pubmed	Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	22695893
Pubmed	SLCO1B1, SLCO2B1, and SLCO1B3 polymorphisms and susceptibility to bladder cancer risk.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	24762081
Pubmed	Role of the murine organic anion-transporting polypeptide 1b2 (Oatp1b2) in drug disposition and hepatotoxicity.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	18492796
Pubmed	Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	28389619
Pubmed	Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	26383540
Pubmed	Organic anion transporting polypeptide 1B transporters modulate hydroxyurea pharmacokinetics.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	23986199
Pubmed	Targeted disruption of murine organic anion-transporting polypeptide 1b2 (Oatp1b2/Slco1b2) significantly alters disposition of prototypical drug substrates pravastatin and rifampin.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	18413659
Pubmed	Alteration in placental expression of bile acids transporters OATP1A2, OATP1B1, OATP1B3 in intrahepatic cholestasis of pregnancy.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	22203093
Pubmed	Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	18296417
Pubmed	Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	20949553
Pubmed	Interaction Between Sex and Organic Anion-Transporting Polypeptide 1b2 on the Pharmacokinetics of Regorafenib and Its Metabolites Regorafenib-N-Oxide and Regorafenib-Glucuronide in Mice.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	30955241
Pubmed	Effects of tuberculosis, race, and human gene SLCO1B1 polymorphisms on rifampin concentrations.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	20660695
Pubmed	Influence of drug formulation on OATP1B-mediated transport of paclitaxel.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	24755470
Pubmed	Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake of Glucuronide Metabolites of Androgens.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	32587096
Pubmed	Comparison of genetic variations of the SLCO1B1, SLCO1B3, and SLCO2B1 genes among five ethnic groups.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	26409184
Pubmed	OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	29337310
Pubmed	Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	22136368
Pubmed	Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	31967785
Pubmed	Organic Anion Transporting Polypeptides Contribute to the Disposition of Perfluoroalkyl Acids in Humans and Rats.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	28013215
Pubmed	The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	19890249
Pubmed	HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	20051929
Pubmed	Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation.	CADPS CBLB	1.94e-05	3	89	2	20400514
Pubmed	Impact of regulatory polymorphisms in organic anion transporter genes in the human liver.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	19620935
Pubmed	Identification of novel cell-impermeant fluorescent substrates for testing the function and drug interaction of Organic Anion-Transporting Polypeptides, OATP1B1/1B3 and 2B1.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	29422623
Pubmed	Identification, expression, and functional characterization of full-length and splice variants of murine organic anion transporting polypeptide 1b2.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	19400585
Pubmed	Synergistic interaction between genetics and disease on pravastatin disposition.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	24613363
Pubmed	OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd-EOB-DTPA uptake and correlates with risk of malignancy.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	30218633
Pubmed	Association of neonatal hyperbilirubinemia in breast-fed infants with UGT1A1 or SLCOs polymorphisms.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	25391605
Pubmed	Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1).	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	10833452
Pubmed	Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	24825069
Pubmed	Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.	SLCO1B3 SLCO1B1	1.94e-05	3	89	2	10779507
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR1N1 OR5M9 OR1I1 OR5B12 OR10S1 OR10R2	2.19e-05	219	89	6	12213199
Pubmed	Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain.	SLCO1B3 SLCO1B1	3.87e-05	4	89	2	22294745
Pubmed	Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.	SLCO1B3 SLCO1B1	3.87e-05	4	89	2	20644253
Pubmed	Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs.	SLCO1B3 SLCO1B1	3.87e-05	4	89	2	19442037
Pubmed	Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study.	FADS3 ELOVL2	3.87e-05	4	89	2	19148276
Pubmed	Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients.	SLCO1B3 SLCO1B1	3.87e-05	4	89	2	17906856
Pubmed	Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells.	SLCO1B3 SLCO1B1	3.87e-05	4	89	2	21849517
Pubmed	Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2.	SLCO1B3 SLCO1B1	3.87e-05	4	89	2	25280775
Pubmed	Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.	SLCO1B3 SLCO1B1	3.87e-05	4	89	2	27777271
Pubmed	Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathway.	TRIB3 EIF2AK4	6.44e-05	5	89	2	21203563
Pubmed	Polymorphisms of the nuclear receptor pregnane X receptor and organic anion transporter polypeptides 1A2, 1B1, 1B3, and 2B1 are not associated with breast cancer risk.	SLCO1B3 SLCO1B1	6.44e-05	5	89	2	20635135
Pubmed	Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population.	SLCO1B3 SLCO1B1	6.44e-05	5	89	2	38279097
Pubmed	OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.	SLCO1B3 SLCO1B1	6.44e-05	5	89	2	24194565
Pubmed	TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.	ACACB TRIB3	6.44e-05	5	89	2	16794074
Pubmed	Analysis of DNA methylation and histone modification profiles of liver-specific transporters.	SLCO1B3 SLCO1B1	9.65e-05	6	89	2	19047482
Pubmed	Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.	SLCO1B3 SLCO1B1	9.65e-05	6	89	2	22232210
Pubmed	Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity.	SLCO1B3 SLCO1B1	9.65e-05	6	89	2	20212519
Pubmed	Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice.	TRIB3 TRPV6	9.65e-05	6	89	2	24691093
Pubmed	BBS mutations modify phenotypic expression of CEP290-related ciliopathies.	BBS9 RHO	1.35e-04	7	89	2	23943788
Pubmed	Differential development of odorant receptor expression patterns in the olfactory epithelium: a quantitative analysis in the mouse septal organ.	OR10K1 OR10K2	1.35e-04	7	89	2	18214836
Pubmed	Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.	SLCO1B3 SLCO1B1	1.79e-04	8	89	2	19129463
Pubmed	Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.	SLCO1B3 SLCO1B1	2.88e-04	10	89	2	18703564
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	TTC7A USP34 CADPS HELZ2 ADCY6	2.89e-04	225	89	5	12168954
Pubmed	Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties.	SLCO1B3 SLCO1B1	3.51e-04	11	89	2	14579113
Pubmed	Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients.	SLCO1B3 SLCO1B1	3.51e-04	11	89	2	18695635
Pubmed	The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.	SLCO1B3 SLCO1B1	4.96e-04	13	89	2	11682476
Pubmed	Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.	FADS3 DOCK7 ELOVL2	5.24e-04	61	89	3	22916037
Pubmed	Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.	SLCO1B3 SLCO1B1	7.59e-04	16	89	2	35307651
Pubmed	Changes in thyroid status during perinatal development of MCT8-deficient male mice.	SLCO1B3 SLCO1B1	9.65e-04	18	89	2	23696569
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ATRN USP34 UBR2 RINT1 LTN1 NADK ST3GAL2 CPVL GTF3C3 WDR62	9.98e-04	1201	89	10	35696571
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ABCA3 LTN1 DOCK7 MEAK7 GTF3C3	1.28e-03	313	89	5	38270169
Cytoband	1q23.1	OR10K1 OR10K2 OR6K3 OR10T2 OR10R2 RGS7	3.94e-10	46	89	6	1q23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr1q23	OR10K1 OR10K2 OR6K3 OR10T2 OR10R2	8.20e-05	226	89	5	chr1q23
Cytoband	Ensembl 112 genes in cytogenetic band chr11q12	ZP1 OR5M9 FADS3 OR9G1 OR5B12	5.77e-04	345	89	5	chr11q12
Cytoband	11p15.4	OR51G2 OR52L2P OR51I2 OR52N5	6.39e-04	200	89	4	11p15.4
GeneFamily	Olfactory receptors, family 10	OR10K1 OR10K2 OR10S1 OR10T2 OR10R2	3.59e-06	66	64	5	157
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TTC7A TTC39C TTC21A GTF3C3	7.35e-04	115	64	4	769
Drug	demethylphalloin	SLCO1B3 DMPK SLCO1B1	1.87e-06	7	87	3	CID000114793
Disease	phosphatidylinositol measurement	FADS3 DOCK7 SLCO1B3 SLCO1B1 ELOVL2	5.12e-06	95	77	5	EFO_0010230
Disease	Rotor syndrome	SLCO1B3 SLCO1B1	6.72e-06	2	77	2	cv:C0220991
Disease	HYPERBILIRUBINEMIA, ROTOR TYPE, DIGENIC	SLCO1B3 SLCO1B1	6.72e-06	2	77	2	C4016905
Disease	HYPERBILIRUBINEMIA, ROTOR TYPE	SLCO1B3 SLCO1B1	6.72e-06	2	77	2	237450
Disease	Rotor Syndrome	SLCO1B3 SLCO1B1	6.72e-06	2	77	2	C0220991
Disease	bilirubin metabolic disorder (implicated_via_orthology)	SLCO1B3 SLCO1B1	6.69e-05	5	77	2	DOID:2741 (implicated_via_orthology)
Disease	cholesteryl ester 22:6 measurement	SIDT2 FADS3 ELOVL2	8.02e-05	32	77	3	EFO_0010350
Disease	level of Phosphatidylcholine (16:0_18:0) in blood serum	FADS3 DOCK7	1.00e-04	6	77	2	OBA_2045069
Disease	bilirubin metabolic disorder (is_implicated_in)	SLCO1B3 SLCO1B1	1.00e-04	6	77	2	DOID:2741 (is_implicated_in)
Disease	deoxycholic acid glucuronide measurement	SLCO1B3 SLCO1B1	1.86e-04	8	77	2	EFO_0800575
Disease	Chagas cardiomyopathy	NAALADL1 IZUMO1R SLCO1B1	2.10e-04	44	77	3	EFO_0005529
Disease	hexadecenedioate (C16:1-DC) measurement	SLCO1B3 SLCO1B1	2.39e-04	9	77	2	EFO_0800562
Disease	X-21467 measurement	SLCO1B3 SLCO1B1	2.39e-04	9	77	2	EFO_0020007
Disease	glycerophospholipid measurement	SIDT2 FADS3 DOCK7	2.89e-04	49	77	3	EFO_0007630
Disease	cholesteryl ester 22:5 measurement	SIDT2 FADS3	2.98e-04	10	77	2	EFO_0021444
Disease	ecosanoids measurement	SLCO1B3 SLCO1B1 ELOVL2	4.07e-04	55	77	3	EFO_0020044
Disease	glycochenodeoxycholate glucuronide (1) measurement	SLCO1B3 SLCO1B1	5.15e-04	13	77	2	EFO_0800474
Disease	chemokine (C-C motif) ligand 27 measurement	SLCO1B3 IREB2 AQP3	8.25e-04	70	77	3	EFO_0008082
Disease	diacylglycerol 38:5 measurement	FADS3 ELOVL2	1.12e-03	19	77	2	EFO_0020067
Disease	level of Phosphatidylinositol (18:0_18:2) in blood serum	FADS3 DOCK7	1.37e-03	21	77	2	OBA_2045156
Disease	HbA1c measurement, response to sulfonylurea	SLCO1B1 BBS9	1.37e-03	21	77	2	EFO_0004541, EFO_0007922
Disease	level of Phosphatidylinositol (18:0_20:4) in blood serum	FADS3 DOCK7	1.64e-03	23	77	2	OBA_2045158
Disease	HbA1c measurement	FADS3 ACACB LALBA CPVL OR10T2 MEAK7 OR10R2	1.91e-03	675	77	7	EFO_0004541
Disease	docosapentaenoic acid measurement	FADS3 ELOVL2	2.26e-03	27	77	2	EFO_0006809
Disease	lysophosphatidylethanolamine 20:4 measurement	FADS3 SLCO1B1	2.61e-03	29	77	2	EFO_0010370

Protein segments in the cluster

Peptide	Gene	Start	Entry
HGALSFMTSPFYLRL	AADACL2	371	Q6P093
MGSHESLGPYFLVFL	ANTXRL	1	A6NF34
LFSLGIIFFEMSYHP	EIF2AK4	926	Q9P2K8
IISCFMGHNFSLPVY	AACS	441	Q86V21
FPHSTLMLGIYASIF	ADCY6	691	O43306
VLPNHCLGMAVSSFY	ABCA3	1251	Q99758
HHYLPLFFDGLCEMT	PACRG	106	Q96M98
DSCLHTPMYFFTGNL	OR9G1	51	Q8NH87
GMVTHYLSSSGVLPY	IREB2	551	P48200
HFTIPMIIIFFCYGQ	RHO	211	P08100
MICFSVIHGFNYSLP	LTN1	1716	O94822
IFLSAIDMYGHQFCP	ACACB	1246	O00763
GAMIDPTLLHYSFAF	CADPS	741	Q9ULU8
CAGHLMVFPIFFGSV	OR6K3	256	Q8NGY3
PMYHFLGHLSFLDAC	OR10S1	71	Q8NGN2
LYNFSLFHCGLLMPG	IZUMO1R	71	A6ND01
VAFFASHTYGMTIPG	MMRN1	1101	Q13201
MLVIFGHCPLYGYIS	ATRN	461	O75882
PDYSILSFMGAFHGR	ABAT	206	P80404
NFLAVTHPGYMAFLT	CBLB	251	Q13191
SMFGLFVEHGPYVVT	CPVL	116	Q9H3G5
CFLMTSGPRGVVHFY	MFSD6L	311	Q8IWD5
VMAFHLGSLGFLTPF	NADK	201	O95544
FYTPMIGLSVIHRFG	OR51G2	256	Q8NGK0
FYVPMIGVSTVHRFG	OR51I2	251	Q9H344
HIPMYFFLGSLAFVD	OR5H2	61	Q8NGV7
ALPELICTMFHTSGY	LALBA	41	P00709
LFSICPSMAVYTHTG	MEAK7	326	Q6P9B6
AIPFVGCLTQMYAFH	OR1I1	91	O60431
GTGIFMYLRPNSSHF	OR5B12	251	Q96R08
VHLPFVGYSYSCMAL	DMPK	396	Q09013
IVGSFMGYLRIFSPH	BBS9	41	Q3SYG4
LHTPMYGFLFILSFS	OR10T2	56	Q8NGX3
ASHFMVVCLFYGPVG	OR12D3	241	Q9UGF7
GPLSVHMACLSFFFL	PAQR8	316	Q8TEZ7
GLPFMCHAGVSTAYI	IL1RL2	311	Q9HB29
SGLLFPFYDADTHML	CORO2B	271	Q9UQ03
FMYCTPFTLDGRAHG	DOCK7	1941	Q96N67
HLPLAVGIAFFLMTF	EFNA3	221	P52797
FGPTLNSFIHILMYS	ELOVL2	171	Q9NXB9
PLVVNMYFATGFSGH	FOXRED1	426	Q96CU9
MFYFHCPPQLEGTAT	DRGX	1	A6NNA5
FGGMEVFPNALYTHC	DCAF12L1	421	Q5VU92
RMHEGICAFPSVAFY	HELZ2	2426	Q9BYK8
CFLVMAYGTTIFHPL	GPR22	351	Q99680
SPTFFAFLLGHILAM	FADS3	131	Q9Y5Q0
GHYFCSVYGARLMVP	DHRS1	126	Q96LJ7
AITFNPGLHAPMYFF	OR13A1	66	Q8NGR1
PMYFFFGHALSLIDL	OR52N5	66	Q8NH56
HTPMYFFLAILSCSE	OR10K1	56	Q8NGX5
AIGSDLHLHTPMYFF	OR1N1	46	Q8NGS0
FLGCSHSFLLAVMGY	OR10K2	106	Q6IF99
HTPMYFFLGILSTSE	OR10R2	76	Q8NGX6
SHVCVILVFYIPGMF	OR52L2P	261	Q8NGH6
ILVFYIPGMFSFLTH	OR52L2P	266	Q8NGH6
VLPFCMVFCGYSLTH	PIGB	366	Q92521
MGIVHGAATYLPDFL	RSBN1L	401	Q6PCB5
LMLCQAFGIIYPSFH	TAS2R20	261	P59543
LGTLMAAHGYFFPIS	RGS7	81	P49802
MFVCGLFFTRPSGSY	SLC6A16	546	Q9GZN6
CGIPKHFGLFYAMGT	SIDT2	541	Q8NBJ9
SKLFPFYFHISMGCA	TMEM205	51	Q6UW68
SGSMEPAFHRGYLLF	SEC11B	41	P0C7V7
TFIFGIMISFHAGPI	SLC26A8	246	Q96RN1
IMISFHAGPISFFYD	SLC26A8	251	Q96RN1
MGHFFYTLPNAVLAG	SLC26A8	446	Q96RN1
LPGICHMAFVVSVYF	PKDREJ	2086	Q9NTG1
YPSTGMLVLFFALHV	ST3GAL2	276	Q16842
SHLTAVSMFYGTPIF	OR5M9	241	Q8NGP3
SPMYFFLGHLSALEI	OR9A4	56	Q8NGU2
IGGVLTALPHFFMGY	SLCO1B1	106	Q9Y6L6
EPLYSFCIGLTFIHM	GTF3C3	766	Q9Y5Q9
IFATYPSGHLDMING	AQP3	146	Q92482
FYFPLTHCGTTMQVA	ZP1	326	P60852
GIPHSSIMGYNFSLL	RHD	321	Q02161
HGYPGTFASCMHILS	RINT1	416	Q6NUQ1
LGAGAMFPPTSIYHV	SLC52A1	421	Q9NWF4
SLGVALFTMLAGHYP	TRIB3	246	Q96RU7
TGSILTSLPHFFMGY	SLCO1B3	106	Q9NPD5
PLLFHVFSNGGVMLY	TMEM53	106	Q6P2H8
LGGPFHVLIITYAFM	TRPV6	461	Q9H1D0
GEPTIFYMLHCGTAL	SRRD	211	Q9UH36
HFSSMQGIPLGSEYF	TTC21A	436	Q8NDW8
MLGHKYGVACVAFSP	WDR62	151	O43379
LPFATMHLCETGFSY	ZBED5	636	Q49AG3
EAAGLFPTSHSVLYM	TTC7A	736	Q9ULT0
VHGTTKLVPYFSFMT	USP34	2746	Q70CQ2
FGYGLFHLCISMVPP	TTC39C	221	Q8N584
GIMPFLKCSALFFHY	UBR2	1511	Q8IWV8
GILPSGMVTFNLYHF	TMEM260	496	Q9NX78
HFGFMGKCTYILAQP	ZAN	1171	Q9Y493
SDYAPFVHFLGISSM	NAALADL1	511	Q9UQQ1