Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	1.68e-16	431	42	16	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 GRM4 OR2T4 OR2T11 AVPR1B OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	4.67e-14	884	42	18	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR2T3 PTCH2 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 GRM4 OR2T4 OR2T11 AVPR1B ITGB2 OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	4.42e-13	1353	42	20	GO:0004888
GeneOntologyMolecularFunction	virus receptor activity	ITGB1 ITGB5 XPR1	7.58e-04	85	42	3	GO:0001618
GeneOntologyMolecularFunction	exogenous protein binding	ITGB1 ITGB5 XPR1	7.84e-04	86	42	3	GO:0140272
GeneOntologyMolecularFunction	phosphate transmembrane transporter activity	SLC37A1 XPR1	1.16e-03	24	42	2	GO:0005315
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	1.05e-16	432	42	16	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	3.35e-16	465	42	16	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	6.49e-16	485	42	16	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	2.17e-15	524	42	16	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	4.25e-15	547	42	16	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	1.11e-14	582	42	16	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	3.07e-13	722	42	16	GO:0051606
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 GRM4 OR2T4 OR2T11 ITGB1 AVPR1B OR4A16 EDN1 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	4.29e-13	1395	42	20	GO:0007186
GeneOntologyBiologicalProcess	sensory perception	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	1.18e-10	1072	42	16	GO:0007600
GeneOntologyBiologicalProcess	positive regulation of organic acid transport	ITGB1 AVPR1B EDN1	2.86e-04	63	42	3	GO:0032892
GeneOntologyBiologicalProcess	symbiont entry into host cell	ITGB1 AVPR1B ITGB5 XPR1	3.82e-04	169	42	4	GO:0046718
GeneOntologyBiologicalProcess	phosphate ion transmembrane transport	SLC37A1 XPR1	4.18e-04	15	42	2	GO:0035435
GeneOntologyBiologicalProcess	symbiont entry into host	ITGB1 AVPR1B ITGB5 XPR1	4.45e-04	176	42	4	GO:0044409
GeneOntologyCellularComponent	integrin complex	ITGB1 ITGB2 ITGB5	3.59e-05	32	42	3	GO:0008305
GeneOntologyCellularComponent	protein complex involved in cell adhesion	ITGB1 ITGB2 ITGB5	2.27e-04	59	42	3	GO:0098636
GeneOntologyCellularComponent	asymmetric, glutamatergic, excitatory synapse	GRM4 ITGB1	1.06e-03	24	42	2	GO:0098985
Domain	Olfact_rcpt	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	1.10e-16	393	42	16	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 AVPR1B OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	2.44e-14	670	42	17	IPR017452
Domain	7tm_1	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 AVPR1B OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	2.89e-14	677	42	17	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 AVPR1B OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	3.50e-14	685	42	17	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 AVPR1B OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	4.03e-14	691	42	17	PS50262
Domain	GPCR_Rhodpsn	OR2T3 OR51T1 OR2W5P OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 AVPR1B OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	4.13e-14	692	42	17	IPR000276
Domain	Integrin_bsu_cyt_dom	ITGB1 ITGB2 ITGB5	2.10e-07	6	42	3	IPR014836
Domain	Integrin_b_cyt	ITGB1 ITGB2 ITGB5	2.10e-07	6	42	3	SM01241
Domain	Integrin_b_cyt	ITGB1 ITGB2 ITGB5	2.10e-07	6	42	3	PF08725
Domain	Integrin_bsu_tail	ITGB1 ITGB2 ITGB5	3.68e-07	7	42	3	IPR012896
Domain	Integrin_B_tail	ITGB1 ITGB2 ITGB5	3.68e-07	7	42	3	SM01242
Domain	Integrin_B_tail	ITGB1 ITGB2 ITGB5	3.68e-07	7	42	3	PF07965
Domain	INB	ITGB1 ITGB2 ITGB5	5.88e-07	8	42	3	SM00187
Domain	Integrin_beta	ITGB1 ITGB2 ITGB5	5.88e-07	8	42	3	PF00362
Domain	Integrin_bsu_VWA	ITGB1 ITGB2 ITGB5	5.88e-07	8	42	3	IPR002369
Domain	Integrin_bsu	ITGB1 ITGB2 ITGB5	8.80e-07	9	42	3	IPR015812
Domain	INTEGRIN_BETA	ITGB1 ITGB2 ITGB5	8.80e-07	9	42	3	PS00243
Domain	PSI_integrin	ITGB1 ITGB2 ITGB5	8.80e-07	9	42	3	PF17205
Domain	Integin_beta_N	ITGB1 ITGB2 ITGB5	8.80e-07	9	42	3	IPR033760
Domain	Integrin_dom	ITGB1 ITGB2 ITGB5	2.35e-05	25	42	3	IPR032695
Domain	-	ITGB1 ITGB5	2.95e-05	4	42	2	1.20.5.630
Domain	PSI	ITGB1 ITGB2 ITGB5	1.31e-04	44	42	3	IPR016201
Domain	PSI	ITGB1 ITGB2 ITGB5	1.50e-04	46	42	3	SM00423
Domain	EGF_extracell	ITGB1 ITGB2 ITGB5	3.31e-04	60	42	3	IPR013111
Domain	EGF_2	ITGB1 ITGB2 ITGB5	3.31e-04	60	42	3	PF07974
Domain	-	ITGB1 ITGB2 ITGB5	6.13e-04	74	42	3	3.40.50.410
Domain	VWFA	ITGB1 ITGB2 ITGB5	8.28e-04	82	42	3	PS50234
Domain	VWA	ITGB1 ITGB2 ITGB5	8.88e-04	84	42	3	SM00327
Domain	VWF_A	ITGB1 ITGB2 ITGB5	1.43e-03	99	42	3	IPR002035
Domain	SNF2_N	CHD9 EP400	2.35e-03	32	42	2	PF00176
Domain	SNF2_N	CHD9 EP400	2.35e-03	32	42	2	IPR000330
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2T3 OR51T1 OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	6.16e-15	389	35	15	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2T3 OR51T1 OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	1.71e-14	417	35	15	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR2T3 OR51T1 OR2T2 OR2T29 OR2T5 OR5M11 OR2T34 GRM4 OR2T4 OR2T11 OR4A16 OR5AP2 OR6C75 OR52N2 OR52E6 OR52N4	4.47e-13	636	35	16	M41834
Pathway	WP_MECHANOREGULATION_AND_PATHOLOGY_OF_YAPTAZ_VIA_HIPPO_AND_NONHIPPO_MECHANISMS	MAPK10 ITGB1 ITGB2 ITGB5	5.26e-06	47	35	4	M39829
Pathway	PID_INTEGRIN_CS_PATHWAY	ITGB1 ITGB2 ITGB5	3.51e-05	26	35	3	M47
Pathway	WP_INTEGRINMEDIATED_CELL_ADHESION	MAPK10 ITGB1 ITGB2 ITGB5	1.14e-04	102	35	4	M39577
Pathway	WP_INTEGRINMEDIATED_CELL_ADHESION	MAPK10 ITGB1 ITGB2 ITGB5	1.14e-04	102	35	4	MM15830
Pathway	PID_UPA_UPAR_PATHWAY	ITGB1 ITGB2 ITGB5	1.51e-04	42	35	3	M174
Pathway	BIOCARTA_LYMPHOCYTE_PATHWAY	ITGB1 ITGB2	2.13e-04	9	35	2	MM1534
Pathway	BIOCARTA_LYMPHOCYTE_PATHWAY	ITGB1 ITGB2	2.13e-04	9	35	2	M22008
Pathway	BIOCARTA_MONOCYTE_PATHWAY	ITGB1 ITGB2	3.25e-04	11	35	2	MM1436
Pathway	BIOCARTA_MONOCYTE_PATHWAY	ITGB1 ITGB2	3.25e-04	11	35	2	M4956
Pathway	BIOCARTA_LYM_PATHWAY	ITGB1 ITGB2	5.35e-04	14	35	2	M1469
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2T29 OR2T5 OR2T4	6.85e-04	70	35	3	MM14984
Pathway	WP_CELLS_AND_MOLECULES_INVOLVED_IN_LOCAL_ACUTE_INFLAMMATORY_RESPONSE	ITGB1 ITGB2	7.96e-04	17	35	2	M39733
Pathway	BIOCARTA_LAIR_PATHWAY	ITGB1 ITGB2	7.96e-04	17	35	2	M3952
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	ITGB1 ITGB2 ITGB5	1.20e-03	85	35	3	M16441
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOGAP_RHOA_SIGNALING_PATHWAY	ITGB1 ITGB5	1.47e-03	23	35	2	M47537
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOGEF_RHOA_SIGNALING_PATHWAY	ITGB1 ITGB5	1.47e-03	23	35	2	M47720
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_CDC42_SIGNALING_PATHWAY	ITGB1 ITGB5	1.87e-03	26	35	2	M47719
Pathway	REACTOME_SYNDECAN_INTERACTIONS	ITGB1 ITGB5	2.02e-03	27	35	2	M27217
Pathway	WP_NANOPARTICLEMEDIATED_ACTIVATION_OF_RECEPTOR_SIGNALING	MAPK10 ITGB1	2.17e-03	28	35	2	M39572
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOG_RAC_SIGNALING_PATHWAY	ITGB1 ITGB5	2.17e-03	28	35	2	M47655
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR2T29 OR2T5 OR5M11 OR2T4 OR4A16 OR52N2 OR52N4	3.75e-12	74	42	7	15081110
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR51T1 OR2T29 OR2T5 OR5M11 OR2T4 OR4A16 OR5AP2 OR6C75 OR52N2 OR52N4	7.79e-12	340	42	10	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR51T1 OR2T29 OR2T5 OR5M11 OR2T4 OR4A16 OR5AP2 OR6C75 OR52N2 OR52N4	7.79e-12	340	42	10	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR51T1 OR2T29 OR2T5 OR5M11 OR2T4 OR4A16 OR5AP2 OR6C75 OR52N2 OR52N4	8.49e-12	343	42	10	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR51T1 OR2T29 OR2T5 OR5M11 OR2T4 OR4A16 OR5AP2 OR6C75 OR52N2 OR52N4	9.25e-12	346	42	10	14611657
Pubmed	The human olfactory receptor gene family.	OR51T1 OR2T2 OR2T5 OR5M11 OR2T34 OR2T4 OR2T11 OR4A16 OR52N2 OR52E6 OR52N4	3.23e-11	541	42	11	14983052
Pubmed	Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit.	ITGB1 ITGB2 ITGB5	1.63e-08	5	42	3	9442085
Pubmed	HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes.	ITGB1 ITGB2 ITGB5	3.27e-08	6	42	3	8757599
Pubmed	Integrins.	ITGB1 ITGB2 ITGB5	3.58e-07	12	42	3	19693543
Pubmed	Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.	ITGB1 ITGB2 ITGB5	3.58e-07	12	42	3	12606711
Pubmed	Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of beta1 and beta2 integrins.	ITGB1 ITGB2	1.42e-06	2	42	2	16415171
Pubmed	beta1 and beta2 integrins activate different signalling pathways in monocytes.	ITGB1 ITGB2	1.42e-06	2	42	2	11931654
Pubmed	Decreased stroma adhesion capacity of CD34+ progenitor cells from mobilized peripheral blood is not lineage- or stage-specific and is associated with low beta 1 and beta 2 integrin expression.	ITGB1 ITGB2	1.42e-06	2	42	2	12183834
Pubmed	The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding.	ITGB1 ITGB2	1.42e-06	2	42	2	11914080
Pubmed	Dissecting Integrin Expression and Function on Memory B Cells in Mice and Humans in Autoimmunity.	ITGB1 ITGB2	1.42e-06	2	42	2	30949178
Pubmed	JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation.	ITGB1 ITGB2	4.27e-06	3	42	2	30024857
Pubmed	Characterization of L-plastin interaction with beta integrin and its regulation by micro-calpain.	ITGB1 ITGB2	4.27e-06	3	42	2	20183869
Pubmed	Roles of integrins in human induced pluripotent stem cell growth on Matrigel and vitronectin.	ITGB1 ITGB5	4.27e-06	3	42	2	19811096
Pubmed	Urokinase-type plasminogen activator binding to its receptor stimulates tumor cell migration by enhancing integrin-mediated signal transduction.	ITGB1 ITGB2	4.27e-06	3	42	2	10388537
Pubmed	Activation of Epac stimulates integrin-dependent homing of progenitor cells.	ITGB1 ITGB2	4.27e-06	3	42	2	18032709
Pubmed	Integrins control dendritic spine plasticity in hippocampal neurons through NMDA receptor and Ca2+/calmodulin-dependent protein kinase II-mediated actin reorganization.	ITGB1 ITGB5	4.27e-06	3	42	2	16467530
Pubmed	The endothelin-integrin axis is involved in macrophage-induced breast cancer cell chemotactic interactions with endothelial cells.	ITGB1 EDN1	4.27e-06	3	42	2	24550382
Pubmed	alpha subunit partners to beta1 and beta2 integrins during IL-4-induced foreign body giant cell formation.	ITGB1 ITGB2	4.27e-06	3	42	2	17311314
Pubmed	Angiopoietin-like 4 interacts with integrins beta1 and beta5 to modulate keratinocyte migration.	ITGB1 ITGB5	4.27e-06	3	42	2	20952587
Pubmed	Increased Expressions of Integrin Subunit β1, β2 and β3 in Patients with Acute Infection.	ITGB1 ITGB2	4.27e-06	3	42	2	26283883
Pubmed	Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors.	ITGB1 ITGB5	4.27e-06	3	42	2	21397862
Pubmed	Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.	ITGB1 ITGB2 ITGB5	4.69e-06	27	42	3	31541017
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR2W5P OR2T2 OR5M11 OR2T34 OR52E6	6.65e-06	219	42	5	12213199
Pubmed	Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.	ITGB1 ITGB2 ITGB5	7.93e-06	32	42	3	23154389
Pubmed	Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking.	ITGB1 ITGB2	8.53e-06	4	42	2	23552075
Pubmed	Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2) and VLA-4 (CD49d/CD29; alpha 4/beta 1) integrins during myeloid cell differentiation.	ITGB1 ITGB2	8.53e-06	4	42	2	8020569
Pubmed	β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments.	ITGB1 ITGB2	8.53e-06	4	42	2	23708002
Pubmed	Differential mRNA regulation of integrin subunits alpha V, beta 1, beta 3, and beta 5 during mouse embryonic organogenesis.	ITGB1 ITGB5	8.53e-06	4	42	2	8821033
Pubmed	Specific phosphorylations transmit signals from leukocyte β2 to β1 integrins and regulate adhesion.	ITGB1 ITGB2	8.53e-06	4	42	2	25278023
Pubmed	Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain.	ITGB1 ITGB5	8.53e-06	4	42	2	21642953
Pubmed	Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization.	ITGB1 ITGB5	8.53e-06	4	42	2	11462216
Pubmed	Chemokine stimulation of lymphocyte alpha 4 integrin avidity but not of leukocyte function-associated antigen-1 avidity to endothelial ligands under shear flow requires cholesterol membrane rafts.	ITGB1 ITGB2	8.53e-06	4	42	2	12163503
Pubmed	Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes.	ITGB1 ITGB2	8.53e-06	4	42	2	12796480
Pubmed	Expression of integrins in cerebral arteriovenous and cavernous malformations.	ITGB1 ITGB5	8.53e-06	4	42	2	16385340
Pubmed	Myosin-X provides a motor-based link between integrins and the cytoskeleton.	ITGB1 ITGB5	8.53e-06	4	42	2	15156152
Pubmed	Beta1 integrins control the formation of cell chains in the adult rostral migratory stream.	ITGB1 ITGB5	8.53e-06	4	42	2	17344408
Pubmed	The anchoring protein RACK1 links protein kinase Cepsilon to integrin beta chains. Requirements for adhesion and motility.	ITGB1 ITGB5	8.53e-06	4	42	2	11934885
Pubmed	HIV-1 tat promotes integrin-mediated HIV transmission to dendritic cells by binding Env spikes and competes neutralization by anti-HIV antibodies.	ITGB1 ITGB5	8.53e-06	4	42	2	23152803
Pubmed	Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption.	ITGB1 ITGB2	8.53e-06	4	42	2	21357746
Pubmed	Adhesion molecules involved in macrophage responses to Wallerian degeneration in the murine peripheral nervous system.	ITGB1 ITGB2	1.42e-05	5	42	2	9421166
Pubmed	PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins.	ITGB1 ITGB5	1.42e-05	5	42	2	18445685
Pubmed	Intercellular adhesion molecule-4 binds alpha(4)beta(1) and alpha(V)-family integrins through novel integrin-binding mechanisms.	ITGB1 ITGB5	1.42e-05	5	42	2	11435317
Pubmed	The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion.	ITGB1 ITGB2	1.42e-05	5	42	2	12171996
Pubmed	RGS10 restricts upregulation by chemokines of T cell adhesion mediated by α4β1 and αLβ2 integrins.	ITGB1 ITGB2	1.42e-05	5	42	2	21705617
Pubmed	Integrin alpha2beta1 mediates the anti-angiogenic and anti-tumor activities of angiocidin, a novel tumor-associated protein.	ITGB1 ITGB2	1.42e-05	5	42	2	16762342
Pubmed	Characterization of plasminogen as an adhesive ligand for integrins alphaMbeta2 (Mac-1) and alpha5beta1 (VLA-5).	ITGB1 ITGB2	1.42e-05	5	42	2	15090462
Pubmed	Gradient of integrin alpha 6A distribution in the myocardium during early heart development.	ITGB1 ITGB5	1.42e-05	5	42	2	7583004
Pubmed	A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5.	ITGB1 ITGB5	1.42e-05	5	42	2	7592829
Pubmed	Both ICAM-1- and VCAM-1-integrin interactions are important in mediating monocyte adhesion to human saphenous vein.	ITGB1 ITGB2	1.42e-05	5	42	2	12097820
Pubmed	α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism.	ITGB1 ITGB5	1.42e-05	5	42	2	27092791
Pubmed	CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions.	ITGB1 ITGB2	1.42e-05	5	42	2	24006483
Pubmed	The CXC-chemokine CXCL4 interacts with integrins implicated in angiogenesis.	ITGB1 ITGB5	1.42e-05	5	42	2	18648521
Pubmed	Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.	ITGB1 ITGB2	2.13e-05	6	42	2	19346499
Pubmed	Fibronectin- and vitronectin-induced microglial activation and matrix metalloproteinase-9 expression is mediated by integrins alpha5beta1 and alphavbeta5.	ITGB1 ITGB5	2.13e-05	6	42	2	17548654
Pubmed	CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.	ITGB1 ITGB5	2.13e-05	6	42	2	32615086
Pubmed	Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations.	ITGB1 ITGB2	2.13e-05	6	42	2	24829201
Pubmed	Rapid leukocyte migration by integrin-independent flowing and squeezing.	ITGB1 ITGB2	2.13e-05	6	42	2	18451854
Pubmed	Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.	ITGB1 ITGB2	2.13e-05	6	42	2	19703720
Pubmed	The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1.	ITGB1 ITGB2	2.13e-05	6	42	2	16980616
Pubmed	RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1.	ITGB1 ITGB2	2.13e-05	6	42	2	14722085
Pubmed	Macrophage network dynamics depend on haptokinesis for optimal local surveillance.	ITGB1 ITGB2	2.13e-05	6	42	2	35343899
Pubmed	Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development.	ITGB1 ITGB5	2.13e-05	6	42	2	8601592
Pubmed	Role of integrins during fertilization in mammals.	ITGB1 ITGB5	2.98e-05	7	42	2	10091056
Pubmed	Spatiotemporal localization of periostin and its potential role in epithelial-mesenchymal transition during palatal fusion.	ITGB1 ITGB5	2.98e-05	7	42	2	21051860
Pubmed	Association of human platelet alloantigen 1 through 5 polymorphisms with ischemic stroke.	ITGB1 ITGB2	2.98e-05	7	42	2	18057877
Pubmed	Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.	ITGB1 ITGB2	2.98e-05	7	42	2	9736715
Pubmed	Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization.	ITGB1 ITGB2	2.98e-05	7	42	2	23395392
Pubmed	A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans.	ITGB1 ITGB2	2.98e-05	7	42	2	19234460
Pubmed	Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells.	ITGB1 ITGB2 ITGB5	3.68e-05	53	42	3	1431091
Pubmed	Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin.	ITGB1 ITGB5	3.97e-05	8	42	2	16005200
Pubmed	Expression patterns of beta1-related alpha integrin subunits in murine lens during embryonic development and wound healing.	ITGB1 ITGB2	3.97e-05	8	42	2	15370361
Pubmed	Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β.	ITGB1 ITGB5	3.97e-05	8	42	2	24036928
Pubmed	The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes.	ITGB1 ITGB2	3.97e-05	8	42	2	10906324
Pubmed	Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha3beta1-integrin in tumour cells.	ITGB1 ITGB5	3.97e-05	8	42	2	16878156
Pubmed	An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase.	ITGB1 ITGB2	3.97e-05	8	42	2	8649427
Pubmed	KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate.	ITGB1 ITGB5	5.10e-05	9	42	2	25063885
Pubmed	Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines.	ITGB1 ITGB2	7.78e-05	11	42	2	23981064
Pubmed	HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3.	ITGB1 ITGB2	7.78e-05	11	42	2	20661303
Pubmed	Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis.	ITGB2 EDN1	7.78e-05	11	42	2	17016617
Pubmed	Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling.	AVPR1B EDN1	1.10e-04	13	42	2	26531127
Pubmed	Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels.	ITGB1 ITGB2	1.10e-04	13	42	2	20563599
Pubmed	EphrinA2 regulates clathrin mediated KSHV endocytosis in fibroblast cells by coordinating integrin-associated signaling and c-Cbl directed polyubiquitination.	ITGB1 ITGB5	1.10e-04	13	42	2	23874206
Pubmed	Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo.	ITGB1 ITGB5	1.48e-04	15	42	2	19576795
Pubmed	Integrin requirement for hippocampal synaptic plasticity and spatial memory.	ITGB1 ITGB5	1.69e-04	16	42	2	12904471
Pubmed	Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival.	ITGB1 ITGB5	1.69e-04	16	42	2	21945075
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	OR2T3 PTCH2 OR2W5P OR2T2 OR2T5 OR2T34 AVPR1B	2.15e-04	1031	42	7	16710414
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	ITGB1 ITGB2 ITGB5	2.51e-04	101	42	3	23382219
Pubmed	CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.	ITGB1 ITGB2	2.67e-04	20	42	2	23620790
Pubmed	Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence.	ITGB1 ITGB5	3.54e-04	23	42	2	23152823
Pubmed	ERp57 is essential for efficient folding of glycoproteins sharing common structural domains.	ITGB1 ITGB5	4.20e-04	25	42	2	17170699
Pubmed	EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition.	ITGB1 ITGB5	5.66e-04	29	42	2	18794329
Pubmed	Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo.	ITGB1 ITGB2	5.66e-04	29	42	2	23708969
Pubmed	Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21.	SIM2 ITGB2	6.06e-04	30	42	2	11374901
Pubmed	A gene expression map of human chromosome 21 orthologues in the mouse.	SLC37A1 SIM2 ITGB2	9.27e-04	158	42	3	12466855
Interaction	DOK1 interactions	IFT122 ITGB1 ITGB2 ITGB5	2.88e-06	59	34	4	int:DOK1
Cytoband	1q44	OR2T3 OR2W5P OR2T2 OR2T29 OR2T5 OR2T34 OR2T4 OR2T11	9.24e-14	110	42	8	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T3 OR2W5P OR2T2 OR2T29 OR2T5 OR2T34 OR2T4 OR2T11	3.19e-13	128	42	8	chr1q44
Cytoband	11p15.4	OR51T1 OR52N2 OR52E6 OR52N4	3.44e-05	200	42	4	11p15.4
Cytoband	8q22.1	DPY19L4 LAPTM4B	6.23e-04	40	42	2	8q22.1
Cytoband	1p34.1	PTCH2 TSPAN1	1.26e-03	57	42	2	1p34.1
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR51T1 OR52N2 OR52E6 OR52N4	1.74e-03	564	42	4	chr11p15
Cytoband	Ensembl 112 genes in cytogenetic band chr21q22	SLC37A1 SIM2 ITGB2	4.98e-03	377	42	3	chr21q22
Cytoband	21q22.3	SLC37A1 ITGB2	6.17e-03	128	42	2	21q22.3
Cytoband	Ensembl 112 genes in cytogenetic band chr3q21	IFT122 ITGB5	9.49e-03	160	42	2	chr3q21
Cytoband	11q12.1	OR5M11 OR5AP2	9.60e-03	161	42	2	11q12.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8q22	DPY19L4 LAPTM4B	1.04e-02	168	42	2	chr8q22
GeneFamily	Olfactory receptors, family 2	OR2T3 OR2W5P OR2T2 OR2T29 OR2T5 OR2T34 OR2T4 OR2T11	2.87e-11	113	34	8	149
GeneFamily	CD molecules\|Integrin beta subunits	ITGB1 ITGB2 ITGB5	5.06e-07	9	34	3	1159
GeneFamily	Olfactory receptors, family 52	OR52N2 OR52E6 OR52N4	1.06e-04	49	34	3	165
Coexpression	MASSARWEH_TAMOXIFEN_RESISTANCE_UP	DPY19L4 SLC37A1 TBC1D15 SIM2 DOCK11 EDN1 TSPAN1	6.72e-06	583	33	7	M17454
Coexpression	GSE3982_BASOPHIL_VS_EFF_MEMORY_CD4_TCELL_DN	MTMR1 GRM4 ITGB1 ITGB2	1.05e-04	196	33	4	M5557
Coexpression	RAMALHO_STEMNESS_UP	TBC1D15 ITGB1 RRN3 LAPTM4B	1.05e-04	196	33	4	M9473
Coexpression	GSE17721_LPS_VS_CPG_1H_BMDC_DN	MTMR1 MAPK10 ITGB1 EDN1	1.13e-04	200	33	4	M3987
Coexpression	GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_45MIN_UP	DPY19L4 CHD9 ITGB5 LAPTM4B	1.13e-04	200	33	4	M6629
Coexpression	RAMALHO_STEMNESS_UP	TBC1D15 ITGB1 RRN3 LAPTM4B	1.20e-04	203	33	4	MM1017
Computational	Genes in the cancer module 412.	ITGB2 ITGB5	2.28e-04	13	19	2	MODULE_412
Computational	Genes in the cancer module 275.	ITGB2 ITGB5	3.50e-04	16	19	2	MODULE_275
Disease	Microcalcification	ITGB1 ITGB2 XPR1	1.56e-05	42	34	3	C0521174
Disease	Calcinosis	ITGB1 ITGB2 XPR1	1.56e-05	42	34	3	C0006663
Disease	Tumoral calcinosis	ITGB1 ITGB2 XPR1	1.56e-05	42	34	3	C0263628
Disease	Nephrosis	ITGB2 EDN1	1.34e-04	15	34	2	C0027720
Disease	Parkinson's disease (implicated_via_orthology)	PTCH2 MAPK10 RRN3	7.83e-04	157	34	3	DOID:14330 (implicated_via_orthology)
Disease	Cardiomyopathies, Primary	ITGB1 EDN1	2.88e-03	69	34	2	C0033141
Disease	Myocardial Diseases, Secondary	ITGB1 EDN1	2.88e-03	69	34	2	C0036529
Disease	cancer (implicated_via_orthology)	ITGB1 ITGB2 ITGB5	3.60e-03	268	34	3	DOID:162 (implicated_via_orthology)
Disease	Cleft Palate	SIM2 EDN1	3.94e-03	81	34	2	C0008925
Disease	Kidney Diseases	IFT122 EDN1	4.64e-03	88	34	2	C0022658

Protein segments in the cluster

Peptide	Gene	Start	Entry
DDSDIYLDSVMCLMY	EP400	2256	Q96L91
YLDSVMCLMYEATPI	EP400	2261	Q96L91
YEMQLLDELPMIYSC	ACER3	86	Q9NUN7
LLGYSMLLMVTCTVY	GRM4	756	Q14833
ELMQYEVMCLELSYS	AGBL1	346	Q96MI9
AQLTSLAMLMLDSYY	MTMR1	446	Q13613
YYLMDLSYSMKDDLE	ITGB1	146	P05556
LLLTEFYMLAAMAYD	OR5M11	106	Q96RB7
YETLMYACCVLMLLI	OR2T2	196	Q6IF00
VLMLMALDRYVAICY	OR52N4	116	Q8NGI2
LALEMYTDLCMFEYA	IFT122	721	Q9HBG6
LDHERMSYLLYQMLC	MAPK10	161	P53779
YLQSDKDMMVSLYCL	NLRP11	571	P59045
LAYLSLMDAIYSTAM	OR4A16	61	Q8NH70
LYEIFMYLCCVLMLL	OR2T4	226	Q8NH00
TSLYETLMYLCCVLM	OR2T5	196	Q6IEZ7
LYIYMMLGSTECVLL	OR2W5P	101	A6NFC9
MYYFLSMLAAVDLCL	OR51T1	61	Q8NGJ9
SLHEPMYYCLAMLDS	OR52E6	56	Q96RD3
MYYCLAMLDSIDLSL	OR52E6	61	Q96RD3
LLMILICAMATYGAY	LAPTM4B	171	Q86VI4
FFISQLALMDLMYLC	OR2T34	66	Q8NGX1
FFISQLALMDLMYLC	OR2T3	66	Q8NH03
VLMLMALDRYVAICY	OR52N2	116	Q8NGI0
TECFLLAMMAYDRYA	OR5AP2	116	Q8NGF4
YYLMDLSLSMKDDLD	ITGB5	141	P18084
TSLYETLMYLCCVLM	OR2T29	196	Q8NH02
YLMDLSYSMLDDLRN	ITGB2	131	P05107
YMLMFADACALLFLI	SLC37A1	496	P57057
DSLEKYLYAFMSMCR	CHD9	1881	Q3L8U1
SLLMCYLYIVKMISE	DOCK11	1281	Q5JSL3
CLAAVTSGMMYALYL	DPY19L4	56	Q7Z388
MDYLLMIFSLLFVAC	EDN1	1	P05305
LSFLMLCYNSAIVYM	FAM126B	181	Q8IXS8
YLLAAMSYDRCMAIC	OR6C75	111	A6NL08
LYETLMYICCVLMLL	OR2T11	191	Q8NH01
ILMSLVLSYMKDVCY	RRN3	316	Q9NYV6
GYLLMLAYACVTMLR	PTCH2	401	Q9Y6C5
IRQYMLDMSLYDSCY	SIM2	191	Q14190
MYEMAEDCYLKTLSL	SH3TC2	1181	Q8TF17
ILMDLEYMICFYSLE	XPR1	406	Q9UBH6
STYMLLAMTLDRYLA	AVPR1B	121	P47901
SYMMDDLELIGLDYL	USP9Y	761	O00507
LHDILMTYCMYDFDL	TBC1D15	436	Q8TC07
ELAAMIVSMYLYCNL	TSPAN1	226	O60635