Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled photoreceptor activity	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	8.33e-09	15	33	4	GO:0008020
GeneOntologyMolecularFunction	photoreceptor activity	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	1.45e-08	17	33	4	GO:0009881
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OPN1MW2 OR5P3 OPN1LW PLXNA3 OR2A14 OPN1MW3 ROS1 OPN1MW OR8B2 OR8B3	4.32e-05	1353	33	10	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OPN1MW2 OR5P3 OPN1LW OR2A14 OPN1MW3 OPN1MW OR8B2 OR8B3	7.39e-05	884	33	8	GO:0004930
GeneOntologyMolecularFunction	odorant binding	OR5P3 OR8B2 OR8B3	1.19e-03	127	33	3	GO:0005549
GeneOntologyMolecularFunction	phosphatidylinositol-3-phosphate binding	SH3PXD2A VPS13B	2.85e-03	48	33	2	GO:0032266
GeneOntologyBiologicalProcess	phototransduction	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	1.50e-06	53	33	4	GO:0007602
GeneOntologyBiologicalProcess	cellular response to light stimulus	OPN1MW2 OPN1LW OPN1MW3 OPN1MW DDB1	1.90e-06	130	33	5	GO:0071482
GeneOntologyBiologicalProcess	detection of visible light	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	2.02e-06	57	33	4	GO:0009584
GeneOntologyBiologicalProcess	detection of light stimulus	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	6.77e-06	77	33	4	GO:0009583
GeneOntologyBiologicalProcess	cellular response to radiation	OPN1MW2 OPN1LW OPN1MW3 OPN1MW DDB1	1.34e-05	194	33	5	GO:0071478
GeneOntologyBiologicalProcess	detection of stimulus	OPN1MW2 OR5P3 OPN1LW OR2A14 OPN1MW3 OPN1MW OR8B2 OR8B3	1.38e-05	722	33	8	GO:0051606
GeneOntologyBiologicalProcess	positive regulation of cytokinesis	OPN1MW2 OPN1LW OPN1MW	9.25e-05	55	33	3	GO:0032467
GeneOntologyBiologicalProcess	spindle assembly involved in female meiosis	CENPE DDB1	1.11e-04	10	33	2	GO:0007056
GeneOntologyBiologicalProcess	detection of external stimulus	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	1.62e-04	173	33	4	GO:0009581
GeneOntologyBiologicalProcess	detection of abiotic stimulus	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	1.69e-04	175	33	4	GO:0009582
GeneOntologyBiologicalProcess	sensory perception	OPN1MW2 OR5P3 OPN1LW OR2A14 OPN1MW3 OPN1MW OR8B2 OR8B3	2.25e-04	1072	33	8	GO:0007600
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OPN1MW2 OR5P3 OPN1LW OR2A14 OPN1MW3 ARRDC3 OPN1MW OR8B2 OR8B3	2.52e-04	1395	33	9	GO:0007186
GeneOntologyBiologicalProcess	cellular response to abiotic stimulus	OPN1MW2 OPN1LW OPN1MW3 OPN1MW DDB1	2.87e-04	371	33	5	GO:0071214
GeneOntologyBiologicalProcess	cellular response to environmental stimulus	OPN1MW2 OPN1LW OPN1MW3 OPN1MW DDB1	2.87e-04	371	33	5	GO:0104004
GeneOntologyBiologicalProcess	response to light stimulus	OPN1MW2 OPN1LW OPN1MW3 OPN1MW DDB1	3.29e-04	382	33	5	GO:0009416
GeneOntologyBiologicalProcess	visual perception	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	4.78e-04	230	33	4	GO:0007601
GeneOntologyBiologicalProcess	sensory perception of light stimulus	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	5.02e-04	233	33	4	GO:0050953
GeneOntologyBiologicalProcess	regulation of cytokinesis	OPN1MW2 OPN1LW OPN1MW	5.27e-04	99	33	3	GO:0032465
GeneOntologyBiologicalProcess	positive regulation of cell division	OPN1MW2 OPN1LW OPN1MW	6.09e-04	104	33	3	GO:0051781
GeneOntologyBiologicalProcess	meiotic spindle assembly	CENPE DDB1	9.14e-04	28	33	2	GO:0090306
GeneOntologyBiologicalProcess	response to radiation	OPN1MW2 OPN1LW OPN1MW3 OPN1MW DDB1	1.14e-03	503	33	5	GO:0009314
GeneOntologyCellularComponent	photoreceptor disc membrane	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	7.51e-08	26	33	4	GO:0097381
GeneOntologyCellularComponent	photoreceptor outer segment	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	2.74e-05	111	33	4	GO:0001750
GeneOntologyCellularComponent	photoreceptor cell cilium	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	6.59e-05	139	33	4	GO:0097733
GeneOntologyCellularComponent	9+0 non-motile cilium	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	9.57e-05	153	33	4	GO:0097731
GeneOntologyCellularComponent	non-motile cilium	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	2.48e-04	196	33	4	GO:0097730
HumanPheno	Blue cone monochromacy	OPN1LW OPN1MW	6.01e-06	2	13	2	HP:0007939
HumanPheno	Cone monochromacy	OPN1LW OPN1MW	6.01e-06	2	13	2	HP:0011517
HumanPheno	Reduced OCT-measured foveal thickness	OPN1LW OPN1MW	1.80e-05	3	13	2	HP:0030619
HumanPheno	Abnormal OCT-measured foveal thickness	OPN1LW OPN1MW	3.60e-05	4	13	2	HP:0030617
HumanPheno	Abnormal foveal morphology on macular OCT	OPN1LW OPN1MW	1.67e-04	8	13	2	HP:0030613
HumanPheno	Abnormality of macular pigmentation	OPN1LW OPN1MW VPS13B	1.97e-04	47	13	3	HP:0008002
HumanPheno	Eccentric visual fixation	OPN1LW OPN1MW	2.67e-04	10	13	2	HP:0025549
HumanPheno	Red-green dyschromatopsia	OPN1LW OPN1MW	3.26e-04	11	13	2	HP:0000642
HumanPheno	Anomalous trichromacy	OPN1LW OPN1MW	3.26e-04	11	13	2	HP:0011519
HumanPheno	Monochromacy	OPN1LW OPN1MW	3.26e-04	11	13	2	HP:0007803
Domain	Opsin_red/grn	OPN1LW OPN1MW3 OPN1MW	4.57e-09	3	32	3	IPR000378
Domain	OPSIN	OPN1LW OPN1MW3 OPN1MW	5.44e-07	10	32	3	PS00238
Domain	Opsin	OPN1LW OPN1MW3 OPN1MW	7.47e-07	11	32	3	IPR001760
Domain	GPCR_Rhodpsn_7TM	OR5P3 OPN1LW OR2A14 OPN1MW3 OPN1MW OR8B2 OR8B3	1.14e-04	670	32	7	IPR017452
Domain	7tm_1	OR5P3 OPN1LW OR2A14 OPN1MW3 OPN1MW OR8B2 OR8B3	1.22e-04	677	32	7	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR5P3 OPN1LW OR2A14 OPN1MW3 OPN1MW OR8B2 OR8B3	1.31e-04	685	32	7	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR5P3 OPN1LW OR2A14 OPN1MW3 OPN1MW OR8B2 OR8B3	1.38e-04	691	32	7	PS50262
Domain	GPCR_Rhodpsn	OR5P3 OPN1LW OR2A14 OPN1MW3 OPN1MW OR8B2 OR8B3	1.39e-04	692	32	7	IPR000276
Domain	Rho_GTPase_activation_prot	PLXNA3 DEPDC1 ARHGAP18	4.54e-04	88	32	3	IPR008936
Domain	Olfact_rcpt	OR5P3 OR2A14 OR8B2 OR8B3	4.36e-03	393	32	4	IPR000725
Domain	RHOGAP	DEPDC1 ARHGAP18	5.37e-03	64	32	2	PS50238
Domain	RhoGAP_dom	DEPDC1 ARHGAP18	5.37e-03	64	32	2	IPR000198
Domain	-	DEPDC1 ARHGAP18	5.37e-03	64	32	2	1.10.555.10
Pathway	REACTOME_SENSORY_PERCEPTION	OPN1MW2 OR5P3 OPN1LW OPN1MW3 APOB OR8B2 OR8B3	3.83e-08	190	26	7	MM15687
Pathway	REACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION	OPN1MW2 OPN1LW OPN1MW3	3.10e-07	8	26	3	MM14880
Pathway	WP_GPCRS_ODORANT	OPN1MW2 OR5P3 OPN1LW OPN1MW3 OR8B2 OR8B3	3.32e-07	157	26	6	MM15872
Pathway	REACTOME_OPSINS	OPN1MW2 OPN1LW OPN1MW3	6.63e-07	10	26	3	MM15063
Pathway	REACTOME_VISUAL_PHOTOTRANSDUCTION	OPN1MW2 OPN1LW OPN1MW3 APOB	2.28e-05	92	26	4	MM14881
Pathway	REACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION	OPN1LW OPN1MW	6.83e-05	7	26	2	M27157
Pathway	REACTOME_SENSORY_PERCEPTION	OR5P3 OPN1LW OR2A14 APOB OPN1MW OR8B2 OR8B3	1.14e-04	636	26	7	M41834
Pathway	REACTOME_OPSINS	OPN1LW OPN1MW	1.17e-04	9	26	2	M6285
Pathway	REACTOME_RETINOID_CYCLE_DISEASE_EVENTS	OPN1LW OPN1MW	2.52e-04	13	26	2	M29612
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR5P3 OR8B2 OR8B3	2.81e-04	70	26	3	MM14984
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	OPN1MW2 OR5P3 OPN1LW OPN1MW3	3.50e-04	186	26	4	MM15994
Pathway	REACTOME_VISUAL_PHOTOTRANSDUCTION	OPN1LW APOB OPN1MW	8.00e-04	100	26	3	M27158
Pubmed	Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy.	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	6.71e-13	4	33	4	29386880
Pubmed	Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	3.35e-12	5	33	4	2937147
Pubmed	Molecular determinants of human red/green color discrimination.	OPN1MW2 OPN1LW OPN1MW	7.78e-10	3	33	3	8185948
Pubmed	X-linked cone dystrophy caused by mutation of the red and green cone opsins.	OPN1MW2 OPN1LW OPN1MW	7.78e-10	3	33	3	20579627
Pubmed	Expression of red/green-cone opsin mutants K82E, P187S, M273K result in unique pathobiological perturbations to cone structure and function.	OPN1MW2 OPN1LW OPN1MW3	7.78e-10	3	33	3	38410159
Pubmed	Chloride-dependent spectral tuning mechanism of L-group cone visual pigments.	OPN1MW2 OPN1LW OPN1MW3	7.78e-10	3	33	3	23350963
Pubmed	Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance.	OPN1MW2 OPN1LW OPN1MW3	7.78e-10	3	33	3	20471354
Pubmed	Multiple hypothalamic cell populations encoding distinct visual information.	OPN1MW2 OPN1LW OPN1MW3	7.78e-10	3	33	3	21224225
Pubmed	Gene-based Therapy in a Mouse Model of Blue Cone Monochromacy.	OPN1MW2 OPN1LW OPN1MW3	7.78e-10	3	33	3	28751656
Pubmed	Circadian Regulation of the Rod Contribution to Mesopic Vision in Mice.	OPN1MW2 OPN1LW OPN1MW3	7.78e-10	3	33	3	36216501
Pubmed	Rescue of M-cone Function in Aged Opn1mw-/- Mice, a Model for Late-Stage Blue Cone Monochromacy.	OPN1MW2 OPN1LW OPN1MW3	7.78e-10	3	33	3	31469404
Pubmed	The molecular genetics and evolution of red and green color vision in vertebrates.	OPN1MW2 OPN1LW OPN1MW3	7.78e-10	3	33	3	11545071
Pubmed	Mechanisms of spectral tuning in the mouse green cone pigment.	OPN1MW2 OPN1LW OPN1MW3	7.78e-10	3	33	3	9238068
Pubmed	Emergence of novel color vision in mice engineered to express a human cone photopigment.	OPN1MW2 OPN1LW OPN1MW3	7.78e-10	3	33	3	17379811
Pubmed	Spectral tuning of a circadian photopigment in a subterranean 'blind' mammal (Spalax ehrenbergi).	OPN1MW2 OPN1LW OPN1MW3	7.78e-10	3	33	3	10567724
Pubmed	Extensive cone-dependent spectral opponency within a discrete zone of the lateral geniculate nucleus supporting mouse color vision.	OPN1MW2 OPN1LW OPN1MW3	7.78e-10	3	33	3	34111401
Pubmed	Co-expression of murine opsins facilitates identifying the site of cone adaptation.	OPN1MW2 OPN1LW OPN1MW3	7.78e-10	3	33	3	12511072
Pubmed	The Pem homeobox gene is X-linked and exclusively expressed in extraembryonic tissues during early murine development.	OPN1MW2 OPN1LW OPN1MW3	7.78e-10	3	33	3	7958444
Pubmed	Genetically engineered mice with an additional class of cone photoreceptors: implications for the evolution of color vision.	OPN1MW2 OPN1LW OPN1MW3	7.78e-10	3	33	3	14500905
Pubmed	Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulated dawn.	OPN1MW2 OPN1LW OPN1MW3	3.11e-09	4	33	3	26438865
Pubmed	Light/dark translocation of alphatransducin in mouse photoreceptor cells expressing G90D mutant opsin.	OPN1MW2 OPN1LW OPN1MW3	3.11e-09	4	33	3	17249565
Pubmed	Structural and functional rescue of cones carrying the most common cone opsin C203R missense mutation.	OPN1MW2 OPN1LW OPN1MW3	3.11e-09	4	33	3	38060327
Pubmed	Contribution of M-opsin-based color vision to refractive development in mice.	OPN1MW2 OPN1LW OPN1MW3	3.11e-09	4	33	3	34126082
Pubmed	Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings.	OPN1MW2 OPN1LW OPN1MW3	3.11e-09	4	33	3	16567464
Pubmed	Visual responses in the dorsal lateral geniculate nucleus at early stages of retinal degeneration in rd1 PDE6β mice.	OPN1MW2 OPN1LW OPN1MW3	3.11e-09	4	33	3	31461375
Pubmed	S-opsin knockout mice with the endogenous M-opsin gene replaced by an L-opsin variant.	OPN1MW2 OPN1LW OPN1MW3	3.11e-09	4	33	3	24801621
Pubmed	Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments.	OPN1MW2 OPN1LW OPN1MW3	3.11e-09	4	33	3	8088841
Pubmed	Modulation of Fast Narrowband Oscillations in the Mouse Retina and dLGN According to Background Light Intensity.	OPN1MW2 OPN1LW OPN1MW3	3.11e-09	4	33	3	28103478
Pubmed	Melanopsin Contributions to the Representation of Images in the Early Visual System.	OPN1MW2 OPN1LW OPN1MW3	3.11e-09	4	33	3	28528909
Pubmed	Molecular biology of the visual pigments.	OPN1MW2 OPN1LW OPN1MW	3.11e-09	4	33	3	3303660
Pubmed	Cones Support Alignment to an Inconsistent World by Suppressing Mouse Circadian Responses to the Blue Colors Associated with Twilight.	OPN1MW2 OPN1LW OPN1MW3	3.11e-09	4	33	3	31846668
Pubmed	Melanopsin-driven light adaptation in mouse vision.	OPN1MW2 OPN1LW OPN1MW3	3.11e-09	4	33	3	25308073
Pubmed	Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function.	OPN1MW2 OPN1LW OPN1MW3	7.77e-09	5	33	3	36631163
Pubmed	Using Silent Substitution to Track the Mesopic Transition From Rod- to Cone-Based Vision in Mice.	OPN1MW2 OPN1LW OPN1MW3	7.77e-09	5	33	3	26818794
Pubmed	A common integration locus in type B retrovirus-induced thymic lymphomas.	OPN1MW2 OPN1LW OPN1MW3	7.77e-09	5	33	3	1333116
Pubmed	Melanopsin-based brightness discrimination in mice and humans.	OPN1MW2 OPN1LW OPN1MW3	7.77e-09	5	33	3	22633808
Pubmed	The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning.	OPN1MW2 OPN1LW OPN1MW3	7.77e-09	5	33	3	11055434
Pubmed	A distinct contribution of short-wavelength-sensitive cones to light-evoked activity in the mouse pretectal olivary nucleus.	OPN1MW2 OPN1LW OPN1MW3	7.77e-09	5	33	3	22090509
Pubmed	Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.	OPN1MW2 OPN1LW OPN1MW3	7.77e-09	5	33	3	10723722
Pubmed	Enhancer/promoter activities of the long/middle wavelength-sensitive opsins of vertebrates mediated by thyroid hormone receptor β2 and COUP-TFII.	OPN1MW2 OPN1LW OPN1MW3	7.77e-09	5	33	3	24058409
Pubmed	Variations in photoreceptor throughput to mouse visual cortex and the unique effects on tuning.	OPN1MW2 OPN1LW OPN1MW3	7.77e-09	5	33	3	34099749
Pubmed	Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.	OPN1MW2 OPN1LW OPN1MW3	7.77e-09	5	33	3	27033727
Pubmed	Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.	OPN1MW2 OPN1LW OPN1MW3	1.55e-08	6	33	3	23288843
Pubmed	Reduced levels of dystrophin associated proteins in the brains of mice deficient for Dp71.	OPN1MW2 OPN1LW OPN1MW3	1.55e-08	6	33	3	8872469
Pubmed	A thyroid hormone receptor that is required for the development of green cone photoreceptors.	OPN1MW2 OPN1LW OPN1MW3	1.55e-08	6	33	3	11138006
Pubmed	Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase.	OPN1MW2 OPN1LW OPN1MW3	1.55e-08	6	33	3	10395695
Pubmed	Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis.	OPN1MW2 OPN1LW OPN1MW3	1.55e-08	6	33	3	17436273
Pubmed	Telomere-related markers for the pseudoautosomal region of the mouse genome.	OPN1MW2 OPN1LW OPN1MW3	1.55e-08	6	33	3	1549575
Pubmed	Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.	OPN1MW2 OPN1LW OPN1MW3	2.72e-08	7	33	3	8378320
Pubmed	Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice.	OPN1MW2 OPN1LW OPN1MW3	2.72e-08	7	33	3	18974269
Pubmed	Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina.	OPN1MW2 OPN1LW OPN1MW3	2.72e-08	7	33	3	30799247
Pubmed	Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta.	OPN1MW2 OPN1LW OPN1MW3	2.72e-08	7	33	3	16574740
Pubmed	Rods progressively escape saturation to drive visual responses in daylight conditions.	OPN1MW2 OPN1LW OPN1MW3	2.72e-08	7	33	3	29180667
Pubmed	Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome.	OPN1MW2 OPN1LW OPN1MW3	2.72e-08	7	33	3	8001979
Pubmed	NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retina.	OPN1MW2 OPN1LW OPN1MW3	2.72e-08	7	33	3	18199774
Pubmed	Mapping of the murine tbl1 gene reveals a new rearrangement between mouse and human X Chromosomes.	OPN1MW2 OPN1LW OPN1MW3	2.72e-08	7	33	3	9880679
Pubmed	Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.	OPN1MW2 OPN1LW OPN1MW3	2.72e-08	7	33	3	19332056
Pubmed	X-chromosome gene order in different Mus species crosses.	OPN1MW2 OPN1LW OPN1MW3	4.34e-08	8	33	3	3416629
Pubmed	The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis.	OPN1MW2 OPN1LW OPN1MW3	4.34e-08	8	33	3	12651948
Pubmed	Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation.	OPN1MW2 OPN1LW OPN1MW3	4.34e-08	8	33	3	31163126
Pubmed	Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors.	OPN1MW2 OPN1LW OPN1MW3	4.34e-08	8	33	3	20203194
Pubmed	Tubby is required for trafficking G protein-coupled receptors to neuronal cilia.	OPN1MW2 OPN1LW OPN1MW3	4.34e-08	8	33	3	23351594
Pubmed	Localization of the mdx mutation within the mouse dystrophin gene.	OPN1MW2 OPN1LW OPN1MW3	4.34e-08	8	33	3	2903046
Pubmed	A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3).	OPN1MW2 OPN1LW OPN1MW3	4.34e-08	8	33	3	10725384
Pubmed	Retinoid X receptor (gamma) is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina.	OPN1MW2 OPN1LW OPN1MW3	4.34e-08	8	33	3	16043864
Pubmed	Nr2e3 functional domain ablation by CRISPR-Cas9D10A identifies a new isoform and generates retinitis pigmentosa and enhanced S-cone syndrome models.	OPN1MW2 OPN1LW OPN1MW3	4.34e-08	8	33	3	33007388
Pubmed	Genetic mapping on the mouse X chromosome of human cDNA clones for the fragile X and Hunter syndromes.	OPN1MW2 OPN1LW OPN1MW3	4.34e-08	8	33	3	1572654
Pubmed	Linkage of amelogenin (Amel) to the distal portion of the mouse X chromosome.	OPN1MW2 OPN1LW OPN1MW3	4.34e-08	8	33	3	1675194
Pubmed	Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development.	OPN1MW2 OPN1LW OPN1MW3	4.34e-08	8	33	3	21813673
Pubmed	Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium.	OPN1MW2 OPN1LW OPN1MW3	6.51e-08	9	33	3	14742273
Pubmed	A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction.	OPN1MW2 OPN1LW OPN1MW3	6.51e-08	9	33	3	27669145
Pubmed	Close linkage of the murine locus bare patches to the X-linked visual pigment gene: implications for mapping human X-linked dominant chondrodysplasia punctata.	OPN1MW2 OPN1LW OPN1MW3	6.51e-08	9	33	3	1973136
Pubmed	Feedback induction of a photoreceptor-specific isoform of retinoid-related orphan nuclear receptor β by the rod transcription factor NRL.	OPN1MW2 OPN1LW OPN1MW3	6.51e-08	9	33	3	25296752
Pubmed	Comparative mapping of the actin-binding protein 280 genes in human and mouse.	OPN1MW2 OPN1LW OPN1MW3	6.51e-08	9	33	3	8088838
Pubmed	Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development.	OPN1MW2 OPN1LW OPN1MW3	6.51e-08	9	33	3	12407160
Pubmed	ZBED4, a cone and Müller cell protein in human retina, has a different cellular expression in mouse.	OPN1MW2 OPN1LW OPN1MW3	6.51e-08	9	33	3	21850176
Pubmed	Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network.	OPN1MW2 OPN1LW OPN1MW3	6.51e-08	9	33	3	28370415
Pubmed	IFT20 is required for opsin trafficking and photoreceptor outer segment development.	OPN1MW2 OPN1LW OPN1MW3	6.51e-08	9	33	3	21307337
Pubmed	Multilocus molecular mapping of the mouse X chromosome.	OPN1MW2 OPN1LW OPN1MW3	6.51e-08	9	33	3	2906327
Pubmed	Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye.	OPN1MW2 OPN1LW OPN1MW3	9.30e-08	10	33	3	21148184
Pubmed	Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function.	OPN1MW2 OPN1LW OPN1MW3	9.30e-08	10	33	3	31949211
Pubmed	Comparative mapping on the mouse and human X chromosomes of a human cDNA clone encoding the vasopressin renal-type receptor (AVP2R).	OPN1MW2 OPN1LW OPN1MW3	9.30e-08	10	33	3	8449515
Pubmed	Mapping of ornithine aminotransferase gene sequences to mouse chromosomes 7, X, and 3.	OPN1MW2 OPN1LW OPN1MW3	9.30e-08	10	33	3	1349842
Pubmed	The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification.	OPN1MW2 OPN1LW OPN1MW3	9.30e-08	10	33	3	32236127
Pubmed	Physical mapping of the loci Gabra3, DXPas8, CamL1, and Rsvp in a region of the mouse X chromosome homologous to human Xq28.	OPN1MW2 OPN1LW OPN1MW3	9.30e-08	10	33	3	1684949
Pubmed	Mapping of the phosphorylase kinase alpha subunit gene on the mouse X chromosome.	OPN1MW2 OPN1LW OPN1MW3	9.30e-08	10	33	3	1973380
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	OPN1MW2 OPN1LW OPN1MW	9.30e-08	10	33	3	8857542
Pubmed	Linkage of a gene for neural cell adhesion molecule, L1 (CamL1) to the Rsvp region of the mouse X chromosome.	OPN1MW2 OPN1LW OPN1MW3	9.30e-08	10	33	3	1964443
Pubmed	Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice.	OPN1MW2 OPN1LW OPN1MW3	1.28e-07	11	33	3	24421398
Pubmed	Physical linkage of the A-raf-1, properdin, synapsin I, and TIMP genes on the human and mouse X chromosomes.	OPN1MW2 OPN1LW OPN1MW3	1.28e-07	11	33	3	1572636
Pubmed	Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome.	OPN1MW2 OPN1LW OPN1MW3	1.70e-07	12	33	3	1679744
Pubmed	The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors.	OPN1MW2 OPN1LW OPN1MW3	1.70e-07	12	33	3	19812316
Pubmed	MAP4K4 is involved in the neuronal development of retinal photoreceptors.	OPN1MW2 OPN1LW OPN1MW3	1.70e-07	12	33	3	37290629
Pubmed	Genetic and physical mapping of the biglycan gene on the mouse X chromosome.	OPN1MW2 OPN1LW OPN1MW3	1.70e-07	12	33	3	8093671
Pubmed	The construction of human somatic cell hybrids containing portions of the mouse X chromosome and their use to generate DNA probes via interspersed repetitive sequence polymerase chain reaction.	OPN1MW2 OPN1LW OPN1MW3	1.70e-07	12	33	3	1916827
Pubmed	Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease.	OPN1MW2 OPN1LW OPN1MW3	1.70e-07	12	33	3	2561974
Pubmed	G protein-coupled receptors participate in cytokinesis.	OPN1MW2 OPN1LW OPN1MW	2.21e-07	13	33	3	22888021
Pubmed	The expression analysis of Sfrs10 and Celf4 during mouse retinal development.	OPN1MW2 OPN1LW OPN1MW3	2.21e-07	13	33	3	23932931
Pubmed	Essential functions of synapsins I and II in synaptic vesicle regulation.	OPN1MW2 OPN1LW OPN1MW3	2.21e-07	13	33	3	7777057
Pubmed	Biphasic expression of thyroid hormone receptor TRβ1 in mammalian retina and anterior ocular tissues.	OPN1MW2 OPN1LW OPN1MW3	2.81e-07	14	33	3	37033230
Interaction	PSMD14 interactions	PLXNA3 APOB DEPDC1 STIP1 PTBP1 ARHGAP18 CENPE DDB1	4.06e-07	527	28	8	int:PSMD14
Cytoband	Ensembl 112 genes in cytogenetic band chrXq28	OPN1MW2 OPN1LW PLXNA3 OPN1MW3 OPN1MW	4.38e-07	213	33	5	chrXq28
Cytoband	Xq28	OPN1MW2 OPN1LW PLXNA3 OPN1MW	7.83e-06	176	33	4	Xq28
Cytoband	6q21	CCN6 CDC40	2.19e-03	96	33	2	6q21
Cytoband	Ensembl 112 genes in cytogenetic band chr6q21	CCN6 CDC40	3.45e-03	121	33	2	chr6q21
Cytoband	Ensembl 112 genes in cytogenetic band chr6q22	ROS1 ARHGAP18	3.79e-03	127	33	2	chr6q22
Cytoband	Ensembl 112 genes in cytogenetic band chr11q24	OR8B2 OR8B3	8.35e-03	191	33	2	chr11q24
GeneFamily	Opsin receptors	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	9.32e-10	11	25	4	215
GeneFamily	Olfactory receptors, family 8	OR8B2 OR8B3	2.07e-03	49	25	2	155
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|368C / Donor, Lineage, Cell class and subclass (all cells)	OPN1LW OPN1MW3 DEPDC1 CENPE	7.30e-06	175	32	4	74800a10f5ff25d5414fbccb0668f92ff077d1cc
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	OPN1LW OPN1MW3 DEPDC1 CENPE	7.64e-06	177	32	4	844017225e9039d1bc621a9630a30c2e9a51b36d
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	OPN1LW OPN1MW3 DEPDC1 CENPE	7.64e-06	177	32	4	26c25d10aa511b64cc7db43a8deea7b5d31bca96
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	OPN1LW DEPDC1 OPN1MW CENPE	8.34e-06	181	32	4	e4dbc09f0210de465d8347969b301c22463a2b7d
Drug	9,11-dcfr	OPN1LW OPN1MW	1.91e-05	5	32	2	CID006443659
Drug	Phpc-1,2	OPN1LW OPN1MW	1.91e-05	5	32	2	CID000173570
Drug	14-fluororetinal	OPN1LW OPN1MW	1.91e-05	5	32	2	CID006438634
Drug	10,20-methanoretinal	OPN1LW OPN1MW	1.91e-05	5	32	2	CID006438558
Drug	trans-retinoyl chloromethane	OPN1LW OPN1MW	1.91e-05	5	32	2	CID006439860
Drug	3-hydroxyretinal	OPN1LW OPN1MW	2.86e-05	6	32	2	CID000151436
Drug	7,8-Dhr	OPN1LW OPN1MW	2.86e-05	6	32	2	CID006443426
Drug	AC1NTD7Z	OPN1LW OPN1MW	2.86e-05	6	32	2	CID005378594
Drug	5,6-epoxy-3-dehydroretinal	OPN1LW OPN1MW	2.86e-05	6	32	2	CID006449988
Drug	4-n-butylaniline	OPN1LW OPN1MW	4.00e-05	7	32	2	CID000007694
Drug	Photoproduct	OPN1LW OPN1MW	1.04e-04	11	32	2	CID000500521
Drug	retinal oxime	OPN1LW OPN1MW	1.04e-04	11	32	2	CID009577279
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A	PLXNA3 NEBL VPS13B TSPYL2	1.32e-04	187	32	4	6978_UP
Disease	blue cone monochromacy (implicated_via_orthology)	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	9.96e-13	4	31	4	DOID:0050679 (implicated_via_orthology)
Disease	BORNHOLM EYE DISEASE	OPN1LW OPN1MW	1.07e-06	2	31	2	C3159311
Disease	Achromatopsia incomplete, X-linked	OPN1LW OPN1MW	1.07e-06	2	31	2	C2931753
Disease	Cone monochromatism	OPN1LW OPN1MW	1.07e-06	2	31	2	C0339537
Disease	BLUE CONE MONOCHROMACY	OPN1LW OPN1MW	1.07e-06	2	31	2	303700
Disease	Red-green dyschromatopsia	OPN1LW OPN1MW	1.07e-06	2	31	2	cv:C0155016
Disease	Cone monochromatism	OPN1LW OPN1MW	1.07e-06	2	31	2	cv:C0339537
Disease	blue cone monochromacy (is_implicated_in)	OPN1LW OPN1MW	1.07e-06	2	31	2	DOID:0050679 (is_implicated_in)
Disease	Endometrial Carcinoma	PLXNA3 FH TSPYL2	5.96e-05	72	31	3	C0476089
Disease	response to alcohol	PCSK1 ARHGAP18 MOB2	6.74e-05	75	31	3	EFO_0005526
Disease	Cone-Rod Dystrophy 2	OPN1LW OPN1MW	4.26e-04	29	31	2	C3489532
Disease	esophageal adenocarcinoma, Barrett's esophagus	MSRA APOB	4.87e-04	31	31	2	EFO_0000280, EFO_0000478
Disease	Endometrial Neoplasms	PLXNA3 TSPYL2	1.70e-03	58	31	2	C0014170
Disease	triglycerides to total lipids in very small VLDL percentage	APOB STIP1	2.40e-03	69	31	2	EFO_0022341

Protein segments in the cluster

Peptide	Gene	Start	Entry
TEVKAITYSAMQVYN	ZBTB8OS	141	Q8IWT0
MVVPKAAIYQTQAFY	ARRDC3	221	Q96B67
AKSATIYNPVIYVFM	OPN1LW	311	P04000
AKSATIYNPVIYVFM	OPN1MW3	311	P0DN78
QYRSAIYPTSAKQME	MSRA	156	Q9UJ68
AKSATIYNPVIYVFM	OPN1MW2	311	P0DN77
FYSTTALKYMVSNPN	KIAA1107	571	Q9UPP5
TAPQYVDFVMSSVQK	MOB2	106	Q70IA6
AIVDISYASNYVPKM	OR2A14	66	Q96R47
VPKQVSAYNMANSFT	PLXNA3	1576	P51805
VIPQYIMYNMANTSK	DEPDC1	216	Q5TB30
KVSSVFYTNVVPMLN	OR8B3	271	Q8NGG8
AKSATIYNPVIYVFM	OPN1MW	311	P04001
QQLSTSYKTMPAYRN	CCN6	186	O95389
SYKNKYGMVAQVTQT	APOB	271	P04114
QEFSGYVQQVKYAMT	FH	246	P07954
TPSNSYTAQRVKMKY	FAM47A	681	Q5JRC9
LVKNVPFNYYTTSAM	DNAH9	2501	Q9NYC9
TTYNMMKTNTAVRPY	SEC22A	96	Q96IW7
SNYKYVSQNCVTSPM	EHMT1	1036	Q9H9B1
QFASTAKYMKNTPYV	CENPE	321	Q02224
AKYMKNTPYVNEVST	CENPE	326	Q02224
MSYNYVVTAQKPTAV	DDB1	1	Q16531
KVSSVFYTNVVPMLN	OR8B2	271	Q96RD0
PTNMTYITNQAAVYF	STIP1	256	P31948
VKEVQYNPTYETMFA	CDC40	76	O60508
TFIYVMPKSSYSTDQ	OR5P3	256	Q8WZ94
YFQTNPYFTNMVIVK	TSPYL2	311	Q9H2G4
PATSYMTCSAYQKVQ	SH3PXD2A	841	Q5TCZ1
QPFSTYMIQIAVKNY	ROS1	1521	P08922
YGQYTMNQESTTIKV	ARHGAP18	41	Q8N392
MQVESSYYSPQKVKS	VPS13B	406	Q7Z7G8
AANTMVNYYTSVTPV	PTBP1	106	P26599
QYKEQNYKATPVSMT	NEBL	656	O76041
MKQPRVYTSYNTVQN	PCSK1	601	P29120