Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

LAMA3 LTBP2 FBN1 FBN2 EDIL3 LTBP4

1.38e-06188386GO:0005201
GeneOntologyMolecularFunctionintegrin binding

CCN4 FBN1 EDIL3 LTBP4 ADAM22

1.94e-05175385GO:0005178
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAMTS16 ADAMTS18 ADAM22 TMPRSS6

7.82e-05120384GO:0004222
GeneOntologyMolecularFunctioncell adhesion molecule binding

TENM1 IZUMO1 CCN4 FBN1 EDIL3 LTBP4 ADAM22

1.19e-04599387GO:0050839
GeneOntologyMolecularFunctionglycosaminoglycan binding

TENM1 CCN4 LTBP2 FBN1 LTBP4

1.47e-04268385GO:0005539
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBN1 FBN2

2.30e-0412382GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBN1 FBN2

3.16e-0414382GO:0097493
GeneOntologyMolecularFunctionheparin binding

TENM1 CCN4 LTBP2 FBN1

4.74e-04192384GO:0008201
GeneOntologyMolecularFunctionmetallopeptidase activity

ADAMTS16 ADAMTS18 ADAM22 TMPRSS6

5.52e-04200384GO:0008237
GeneOntologyMolecularFunctioncalcium ion binding

LTBP2 FBN1 FBN2 EGFL8 EDIL3 LTBP4

2.70e-03749386GO:0005509
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2

1.98e-054382GO:0035583
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 FBN2

9.19e-058382GO:0071694
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

LTBP2 FBN1 FBN2 IGSF1 LTBP4 TMPRSS6

1.50e-04445386GO:0141091
GeneOntologyBiologicalProcesssequestering of extracellular ligand from receptor

FBN1 FBN2

1.80e-0411382GO:0035581
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

LTBP2 FBN1 FBN2 IGSF1 LTBP4 TMPRSS6

2.31e-04482386GO:0007178
GeneOntologyBiologicalProcessextracellular regulation of signal transduction

FBN1 FBN2

2.55e-0413382GO:1900115
GeneOntologyBiologicalProcessextracellular negative regulation of signal transduction

FBN1 FBN2

2.55e-0413382GO:1900116
GeneOntologyCellularComponentextracellular matrix

ADAMTS16 LAMA3 ADAMTS18 CCN4 LTBP2 FBN1 FBN2 ZAN EDIL3 LTBP4

2.42e-076563910GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

ADAMTS16 LAMA3 ADAMTS18 CCN4 LTBP2 FBN1 FBN2 ZAN EDIL3 LTBP4

2.48e-076583910GO:0030312
GeneOntologyCellularComponentmicrofibril

FBN1 FBN2 LTBP4

1.70e-0613393GO:0001527
GeneOntologyCellularComponentcollagen-containing extracellular matrix

LAMA3 LTBP2 FBN1 FBN2 EDIL3 LTBP4

4.14e-04530396GO:0062023
HumanPhenoAbnormal upper to lower segment ratio

FBN1 FBN2

3.95e-053192HP:0012772
HumanPhenoMicrospherophakia

LTBP2 FBN1

7.87e-054192HP:0030961
HumanPhenoIridodonesis

LTBP2 FBN1

1.31e-045192HP:0100693
HumanPhenoSpherophakia

LTBP2 FBN1

1.31e-045192HP:0034375
MousePhenooverexpanded pulmonary alveolus

ADAMTS18 FBN1 TMTC3 LTBP4

2.30e-0637364MP:0001183
DomainEGF

SCARF1 TENM1 LAMA3 LTBP2 FBN1 FBN2 ZAN EGFL8 EDIL3 LTBP4 ADAM22

8.83e-132353811SM00181
DomainEGF-like_dom

SCARF1 TENM1 LAMA3 LTBP2 FBN1 FBN2 ZAN EGFL8 EDIL3 LTBP4 ADAM22

1.66e-122493811IPR000742
DomainEGF_1

SCARF1 TENM1 LAMA3 LTBP2 FBN1 FBN2 ZAN EGFL8 EDIL3 LTBP4 ADAM22

2.15e-122553811PS00022
DomainEGF-like_CS

SCARF1 TENM1 LAMA3 LTBP2 FBN1 FBN2 ZAN EGFL8 EDIL3 LTBP4 ADAM22

2.77e-122613811IPR013032
DomainEGF_2

SCARF1 TENM1 LAMA3 LTBP2 FBN1 FBN2 ZAN EGFL8 EDIL3 LTBP4 ADAM22

3.27e-122653811PS01186
DomainEGF_3

SCARF1 TENM1 LTBP2 FBN1 FBN2 ZAN EGFL8 EDIL3 LTBP4 ADAM22

2.85e-112353810PS50026
DomainTB

LTBP2 FBN1 FBN2 LTBP4

5.07e-107384PF00683
Domain-

LTBP2 FBN1 FBN2 LTBP4

1.01e-0983843.90.290.10
DomainTB

LTBP2 FBN1 FBN2 LTBP4

1.82e-099384PS51364
DomainTB_dom

LTBP2 FBN1 FBN2 LTBP4

1.82e-099384IPR017878
DomainGrowth_fac_rcpt_

SCARF1 LAMA3 CCN4 LTBP2 FBN1 FBN2 LTBP4

2.52e-08156387IPR009030
DomainEGF_Ca-bd_CS

LTBP2 FBN1 FBN2 EGFL8 EDIL3 LTBP4

4.05e-0897386IPR018097
DomainEGF_CA

LTBP2 FBN1 FBN2 EGFL8 EDIL3 LTBP4

4.58e-0899386PS01187
DomainASX_HYDROXYL

LTBP2 FBN1 FBN2 EGFL8 EDIL3 LTBP4

4.87e-08100386PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

LTBP2 FBN1 FBN2 EGFL8 EDIL3 LTBP4

6.90e-08106386IPR000152
DomainEGF_extracell

SCARF1 TENM1 LTBP2 EDIL3 ADAM22

1.34e-0760385IPR013111
DomainEGF_2

SCARF1 TENM1 LTBP2 EDIL3 ADAM22

1.34e-0760385PF07974
DomainEGF_CA

LTBP2 FBN1 FBN2 EGFL8 EDIL3 LTBP4

1.60e-07122386SM00179
DomainEGF-like_Ca-bd_dom

LTBP2 FBN1 FBN2 EGFL8 EDIL3 LTBP4

1.76e-07124386IPR001881
DomainEGF_CA

LTBP2 FBN1 FBN2 EGFL8 LTBP4

8.20e-0786385PF07645
DomainFBN

FBN1 FBN2

1.21e-053382IPR011398
DomainPeptidase_M12B_N

ADAMTS16 ADAMTS18 ADAM22

6.75e-0539383IPR002870
DomainPep_M12B_propep

ADAMTS16 ADAMTS18 ADAM22

6.75e-0539383PF01562
DomainDISINTEGRIN_1

ADAMTS16 ADAMTS18 ADAM22

7.29e-0540383PS00427
DomainADAM_MEPRO

ADAMTS16 ADAMTS18 ADAM22

7.29e-0540383PS50215
DomainDISINTEGRIN_2

ADAMTS16 ADAMTS18 ADAM22

7.29e-0540383PS50214
DomainReprolysin

ADAMTS16 ADAMTS18 ADAM22

7.29e-0540383PF01421
DomainPeptidase_M12B

ADAMTS16 ADAMTS18 ADAM22

7.29e-0540383IPR001590
DomainDisintegrin_dom

ADAMTS16 ADAMTS18 ADAM22

7.85e-0541383IPR001762
DomainEGF

LTBP2 ZAN EGFL8 EDIL3

1.22e-04126384PF00008
DomainTSP_1

ADAMTS16 ADAMTS18 CCN4

2.84e-0463383PF00090
DomainNHL

TENM1 TRIM71

3.10e-0413382PS51125
DomainTSP1

ADAMTS16 ADAMTS18 CCN4

3.11e-0465383SM00209
DomainTSP1_rpt

ADAMTS16 ADAMTS18 CCN4

3.11e-0465383IPR000884
DomainTSP1

ADAMTS16 ADAMTS18 CCN4

3.11e-0465383PS50092
DomainPLAC

ADAMTS16 ADAMTS18

3.61e-0414382PF08686
DomainMetalloPept_cat_dom

ADAMTS16 ADAMTS18 ADAM22

5.94e-0481383IPR024079
Domain-

ADAMTS16 ADAMTS18 ADAM22

5.94e-04813833.40.390.10
DomainPLAC

ADAMTS16 ADAMTS18

6.74e-0419382IPR010909
DomainPLAC

ADAMTS16 ADAMTS18

6.74e-0419382PS50900
DomainADAM_spacer1

ADAMTS16 ADAMTS18

9.93e-0423382IPR010294
DomainADAM_spacer1

ADAMTS16 ADAMTS18

9.93e-0423382PF05986
DomainZINC_PROTEASE

ADAMTS16 ADAMTS18 ADAM22

1.03e-0398383PS00142
DomainPeptidase_M12B_ADAM-TS

ADAMTS16 ADAMTS18

1.08e-0324382IPR013273
DomaincEGF

FBN1 FBN2

1.27e-0326382IPR026823
DomaincEGF

FBN1 FBN2

1.27e-0326382PF12662
DomainhEGF

FBN2 EDIL3

1.47e-0328382PF12661
DomainLaminin_EGF

SCARF1 LAMA3

2.30e-0335382PF00053
DomainDNA/RNA_helicase_DEAH_CS

CHD5 DDX11

2.30e-0335382IPR002464
DomainVWFC_1

CCN4 ZAN

2.43e-0336382PS01208
DomainVWC

CCN4 ZAN

2.71e-0338382SM00214
DomainLaminin_EGF

SCARF1 LAMA3

2.71e-0338382IPR002049
DomainDEAH_ATP_HELICASE

CHD5 DDX11

2.71e-0338382PS00690
DomainVWFC_2

CCN4 ZAN

2.71e-0338382PS50184
Domain-

TENM1 TRIM71

2.85e-03393822.120.10.30
DomainCYSTEINE_SWITCH

ADAMTS16 ADAMTS18

3.14e-0341382PS00546
DomainVWF_dom

CCN4 ZAN

3.30e-0342382IPR001007
DomainPept_M10_metallopeptidase

ADAMTS16 ADAMTS18

3.45e-0343382IPR001818
Domain6-blade_b-propeller_TolB-like

TENM1 TRIM71

3.94e-0346382IPR011042
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

ADAMTS16 LAMA3 ADAMTS18 LTBP2 FBN1 FBN2 LTBP4 TMPRSS6

1.42e-08300238M610
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

ADAMTS16 LAMA3 ADAMTS18 FBN1 FBN2 TMPRSS6

7.57e-08140236M587
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

LTBP2 FBN1 FBN2 LTBP4

1.88e-0732234MM14854
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

LTBP2 FBN1 FBN2 LTBP4

3.43e-0737234M27134
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

LTBP2 FBN1 FBN2 LTBP4

4.26e-0739234MM14601
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

LTBP2 FBN1 FBN2 LTBP4

7.00e-0744234M26969
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

LTBP2 FBN1 FBN2

8.52e-0625233M39713
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

LTBP2 FBN1 LTBP4

3.08e-0538233MM14874
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

LTBP2 FBN1 FBN2 LTBP4 TMPRSS6

5.07e-05258235MM14572
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

LTBP2 FBN1 LTBP4

5.87e-0547233M646
PathwayKEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA

FBN1 LTBP4

7.09e-058232M47850
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

LTBP2 FBN1 LTBP4

2.57e-0477233MM14670
PathwayPID_INTEGRIN5_PATHWAY

FBN1 EDIL3

3.41e-0417232M212
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

LTBP2 FBN1 LTBP4

4.62e-0494233M1041
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

FBN1 FBN2 TMPRSS6

8.11e-04114233MM14571
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

LTBP2 FBN1 LTBP4

8.96e-04118233MM15588
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS16 ADAMTS18

1.82e-0339232MM15165
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS16 ADAMTS18

1.82e-0339232M27417
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

LTBP2 FBN1 LTBP4

2.19e-03161233M27871
PathwayPID_INTEGRIN3_PATHWAY

FBN1 EDIL3

2.21e-0343232M53
PathwayPID_INTEGRIN1_PATHWAY

LAMA3 FBN1

5.13e-0366232M18
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS16 ADAMTS18

5.43e-0368232M27303
Pubmed

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

FBN1 FBN2 LTBP4

5.21e-09439312429738
Pubmed

Adamts18 modulates the development of the aortic arch and common carotid artery.

LAMA3 ADAMTS18 FBN1 FBN2

1.98e-082639434189436
Pubmed

Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.

ADAMTS16 ADAMTS18 FBN1 FBN2

8.68e-083739434323105
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

LAMA3 LTBP2 FBN1 EDIL3 LTBP4

6.25e-0714639527068509
Pubmed

ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.

ADAMTS16 LAMA3 ADAMTS18

7.23e-071639330579834
Pubmed

ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.

ADAMTS18 FBN1 FBN2

1.05e-061839339040056
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

1.23e-06239212399449
Pubmed

Latent TGF-β binding protein 2 and 4 have essential overlapping functions in microfibril development.

LTBP2 LTBP4

1.23e-06239228252045
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

1.23e-06239221851253
Pubmed

Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.

FBN1 FBN2

1.23e-06239212429739
Pubmed

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

FBN1 FBN2

1.23e-06239224833718
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

1.23e-06239230044367
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

1.23e-06239221440062
Pubmed

MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.

FBN1 FBN2

1.23e-06239215131124
Pubmed

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

FBN1 FBN2

1.23e-06239224265020
Pubmed

Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.

FBN1 FBN2

1.23e-06239212524050
Pubmed

In vivo studies of mutant fibrillin-1 microfibrils.

FBN1 FBN2

1.23e-06239220529844
Pubmed

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.

FBN1 FBN2

1.23e-06239225524144
Pubmed

Microfibril structure masks fibrillin-2 in postnatal tissues.

FBN1 FBN2

1.23e-06239220404337
Pubmed

Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

FBN1 FBN2

1.23e-06239223133647
Pubmed

Fibrillln mutations in Marfan syndrome and related phenotypes.

FBN1 FBN2

1.23e-0623928791520
Pubmed

Evaluation of ADAMTS12, ADAMTS16, ADAMTS18 and IL-33 serum levels in pre-eclampsia.

ADAMTS16 ADAMTS18

1.23e-06239226382559
Pubmed

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.

FBN1 FBN2

1.23e-0623928120105
Pubmed

The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.

FBN1 FBN2

1.23e-06239235419902
Pubmed

Confocal microscopy demonstrates association of LTBP-2 in fibrillin-1 microfibrils and colocalisation with perlecan in the disc cell pericellular matrix.

LTBP2 FBN1

1.23e-06239224867584
Pubmed

Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.

FBN1 FBN2

1.23e-0623928307578
Pubmed

Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

FBN1 FBN2

1.23e-06239216407178
Pubmed

Fibrillin assembly: dimer formation mediated by amino-terminal sequences.

FBN1 FBN2

1.23e-06239210504303
Pubmed

Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.

FBN1 FBN2

1.23e-0623921852206
Pubmed

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.

FBN1 FBN2

1.23e-06239210359653
Pubmed

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

FBN1 FBN2

1.23e-0623927744963
Pubmed

Fibrillin microfibrils in bone physiology.

FBN1 FBN2

1.23e-06239226408953
Pubmed

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

FBN1 FBN2

1.23e-06239218006876
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

LAMA3 LTBP2 FBN1 FBN2 LTBP4

1.53e-0617539528071719
Pubmed

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

LTBP2 FBN1 FBN2 EDIL3

2.68e-068639428327460
Pubmed

Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.

FBN1 FBN2

3.67e-06339210825173
Pubmed

LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein.

LTBP2 FBN1

3.67e-06339217293099
Pubmed

Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.

FBN1 FBN2

3.67e-06339230201140
Pubmed

Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.

FBN1 FBN2

3.67e-06339220855508
Pubmed

ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.

ADAMTS18 FBN1 FBN2

5.18e-063039332882513
Pubmed

Human eye development is characterized by coordinated expression of fibrillin isoforms.

FBN1 FBN2

7.34e-06439225406291
Pubmed

Comparative immunolocalization of the elastin fiber-associated proteins fibrillin-1, LTBP-2, and MAGP-1 with components of the collagenous and proteoglycan matrix of the fetal human intervertebral disc.

LTBP2 FBN1

7.34e-06439221540769
Pubmed

Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability.

LTBP2 LTBP4

7.34e-06439215611103
Pubmed

Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.

FBN1 FBN2

7.34e-06439220729550
Pubmed

Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.

FBN1 FBN2

7.34e-06439225034023
Pubmed

Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18.

ADAMTS16 ADAMTS18

7.34e-06439216507336
Pubmed

The latent transforming growth factor beta binding protein (LTBP) family.

LTBP2 LTBP4

7.34e-06439211104663
Pubmed

Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.

FBN1 FBN2

7.34e-06439216835936
Pubmed

Weill-Marchesani Syndrome

LTBP2 FBN1

7.34e-06439220301293
Pubmed

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.

IKZF1 ZAN TMPRSS6

8.32e-063539319862010
Pubmed

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.

FBN1 FBN2

1.22e-05539226601954
Pubmed

Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.

FBN1 FBN2

1.22e-05539217255108
Pubmed

POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.

FBN1 FBN2

1.22e-05539234411563
Pubmed

Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.

FBN1 FBN2

1.22e-05539212590922
Pubmed

Development, composition, and structural arrangements of the ciliary zonule of the mouse.

FBN1 FBN2

1.22e-05539223493297
Pubmed

Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites.

FBN1 LTBP4

1.83e-05639219349279
Pubmed

Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.

LTBP2 FBN1

1.83e-05639219182256
Pubmed

Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome.

FBN1 FBN2

1.83e-0563927873879
Pubmed

Developmental expression of latent transforming growth factor beta binding protein 2 and its requirement early in mouse development.

LTBP2 FBN1

2.56e-05739210848613
Pubmed

Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.

ADAMTS16 ADAMTS18

2.56e-05739211867212
Pubmed

Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta.

LTBP2 LTBP4

2.56e-05739210930463
Pubmed

Regulation of limb patterning by extracellular microfibrils.

FBN1 FBN2

2.56e-05739211470817
Pubmed

Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis.

FBN1 FBN2

3.42e-05839223055981
Pubmed

Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.

FBN1 FBN2

3.42e-05839231201465
Pubmed

Targeting of bone morphogenetic protein growth factor complexes to fibrillin.

FBN1 FBN2

3.42e-05839218339631
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

LAMA3 LTBP2 FBN1 LTBP4

3.70e-0516739422159717
Pubmed

Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.

FBN1 FBN2

4.39e-05939212122015
Pubmed

Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.

FBN1 FBN2

4.39e-05939238844137
Pubmed

Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia.

FBN1 FBN2

5.48e-051039230738849
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

MTMR3 FBN1 FBN2

7.07e-057139333541421
Pubmed

Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.

FBN1 FBN2

8.03e-051239226405179
Pubmed

A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development.

FBN1 FBN2

8.03e-051239236779913
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS16 ADAMTS18 CCN4

8.32e-057539320637190
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

TOGARAM2 SCARF1 FBN1 FBN2 KLHDC7A ZAN

9.81e-0567439637196079
Pubmed

Morphogenesis of the kidney and lung requires branch-tip directed activity of the Adamts18 metalloprotease.

ADAMTS16 ADAMTS18

1.11e-041439231242448
Pubmed

The species-specific differences in the cAMP regulation of the tissue-type plasminogen activator gene between rat, mouse and human is caused by a one-nucleotide substitution in the cAMP-responsive element of the promoters.

ADAMTS16 ADAMTS18

1.27e-04153927543410
Pubmed

Sall4 is essential for mouse primordial germ cell specification by suppressing somatic cell program genes.

EDIL3 CHD5

1.65e-041739225263278
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

CCN4 LTBP2 FBN1 LTBP4

1.71e-0424839424006456
Pubmed

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.

LTBP2 FBN1 LTBP4

1.79e-049739327559042
Pubmed

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.

FBN1 FBN2

1.85e-041839235503090
Pubmed

Proteomics characterization of extracellular space components in the human aorta.

LTBP2 FBN1 LTBP4

2.01e-0410139320551380
Pubmed

Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease.

EDIL3 ADAM22

3.62e-042539221518438
Pubmed

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

FBN1 FBN2 LTBP4

4.72e-0413539328675934
Pubmed

Heritable Thoracic Aortic Disease Overview

FBN1 FBN2

5.23e-043039220301299
Pubmed

L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.

LTBP2 SPACA1 LTBP4

5.58e-0414339320424473
Pubmed

Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.

FBN1 FBN2

5.58e-043139225762570
Pubmed

O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development.

FBN1 FBN2

7.54e-043639235167946
Pubmed

Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.

LTBP2 LTBP4

7.54e-043639220587546
Pubmed

Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis.

FBN1 FBN2

9.30e-044039230578393
InteractionNTN5 interactions

FBN1 FBN2 LTBP4

1.32e-0524393int:NTN5
InteractionADAMTS19 interactions

ADAMTS16 ADAMTS18

3.64e-055392int:ADAMTS19
InteractionFBXO2 interactions

LAMA3 FBN1 FBN2 TMTC3 EDIL3 LTBP4

1.28e-04411396int:FBXO2
InteractionMFAP5 interactions

FBN1 FBN2 LTBP4

1.39e-0452393int:MFAP5
InteractionZNF408 interactions

LTBP2 FBN1 FBN2 LTBP4

1.74e-04145394int:ZNF408
InteractionZFP41 interactions

FBN1 FBN2 LTBP4

1.82e-0457393int:ZFP41
InteractionMFAP2 interactions

FBN1 FBN2

2.38e-0412392int:MFAP2
InteractionHRG interactions

FBN1 FBN2 LTBP4

2.46e-0463393int:HRG
InteractionFBN2 interactions

LTBP2 FBN1 FBN2

2.69e-0465393int:FBN2
CytobandXq25

TENM1 IGSF1

5.65e-0441392Xq25
CytobandEnsembl 112 genes in cytogenetic band chrXq26

IGSF1 ZDHHC9

9.34e-03171392chrXq26
GeneFamilyLatent transforming growth factor beta binding proteins

LTBP2 LTBP4

1.29e-054272628
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS16 ADAMTS18

3.62e-041927250
CoexpressionNABA_ECM_GLYCOPROTEINS

LAMA3 CCN4 LTBP2 FBN1 FBN2 EDIL3 LTBP4

1.23e-08191397MM17059
CoexpressionNABA_ECM_GLYCOPROTEINS

LAMA3 CCN4 LTBP2 FBN1 FBN2 EDIL3 LTBP4

1.47e-08196397M3008
CoexpressionNABA_CORE_MATRISOME

LAMA3 CCN4 LTBP2 FBN1 FBN2 EDIL3 LTBP4

1.32e-07270397MM17057
CoexpressionNABA_CORE_MATRISOME

LAMA3 CCN4 LTBP2 FBN1 FBN2 EDIL3 LTBP4

1.50e-07275397M5884
CoexpressionNABA_MATRISOME

ADAMTS16 LAMA3 ADAMTS18 CCN4 LTBP2 FBN1 FBN2 EGFL8 EDIL3 LTBP4 ADAM22

1.61e-0710083911MM17056
CoexpressionNABA_MATRISOME

ADAMTS16 LAMA3 ADAMTS18 CCN4 LTBP2 FBN1 FBN2 EGFL8 EDIL3 LTBP4 ADAM22

1.92e-0710263911M5889
CoexpressionMEISSNER_NPC_HCP_WITH_H3K4ME2

ADAMTS18 IKZF1 SHCBP1L C2CD4C LTBP4 CHD5

8.28e-05493396M1951
CoexpressionMEISSNER_NPC_HCP_WITH_H3K4ME2

ADAMTS18 IKZF1 SHCBP1L C2CD4C LTBP4 CHD5

9.34e-05504396MM830
CoexpressionTGFB_UP.V1_UP

LTBP2 SHCBP1L ZNF654 ADAM22

1.77e-04189394M2839
CoexpressionGSE22935_UNSTIM_VS_48H_MBOVIS_BCG_STIM_MACROPHAGE_UP

ZAN TMTC3 EGFL8 EDIL3

2.20e-04200394M7777
CoexpressionGSE43955_1H_VS_42H_ACT_CD4_TCELL_DN

TENM1 FBN1 OGG1 LTBP4

2.20e-04200394M9665
CoexpressionHALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

LAMA3 FBN1 FBN2 EDIL3

2.20e-04200394M5930
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS16 LTBP2 FBN1 IGSF1 LTBP4

5.42e-0718339506a68fa2be36448064f4668be24a5b85ad85c6e8
ToppCellnormal_Lung-Fibroblasts-Myofibroblasts|normal_Lung / Location, Cell class and cell subclass

ADAMTS16 CCN4 LTBP2 FBN1 EDIL3

5.57e-071843950b336489c10e8c3c957795dd845454f03404382b
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

CCN4 LTBP2 FBN1 FBN2 TMTC3

5.72e-07185395427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LTBP2 FBN1 C2CD4C LTBP4 TMPRSS6

6.20e-07188395b382d18fb09fb2869f3c151efa71540a7f5ed229
ToppCellFibroblast-C|World / shred on cell class and cell subclass (v4)

CCN4 LTBP2 FBN1 FBN2 LTBP4

6.36e-0718939558e0400fbab5a0755504275aef5cf7986149abab
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCN4 LTBP2 FBN1 FBN2 LTBP4

6.87e-07192395ad48c941a3ddfd9a5146bafc2209da577bb50531
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_2-SCMF|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ADAMTS16 CCN4 LTBP2 FBN1 EDIL3

6.87e-0719239567e845e513e76e820f55e2f0d15eb16f2944d05c
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCN4 LTBP2 FBN1 FBN2 LTBP4

6.87e-0719239519b94f254d51b9bda3d9b7c6f85e27ecb58409c8
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ADAMTS16 CCN4 LTBP2 FBN1 EDIL3

7.05e-071933955de87fc94a6e58899ef4124cf4887ed3ff96163a
ToppCellCOVID-19-Fibroblasts-Intermediate_pathological_FB|COVID-19 / group, cell type (main and fine annotations)

ADAMTS16 CCN4 LTBP2 FBN1 EDIL3

7.80e-07197395f1c8936986123a3151140c374fcd62d6705c530b
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS18 CCN4 FBN2 EDIL3 LTBP4

7.80e-071973952e3d64648a1e4f01b9256a96b94b8a640ee1824c
ToppCelltumor_Lung-Fibroblasts-Myofibroblasts|tumor_Lung / Location, Cell class and cell subclass

ADAMTS16 CCN4 LTBP2 FBN1 EDIL3

8.00e-0719839531f9181dab689aabe9c6182c2ef7de65ba3f0ff6
ToppCellBiopsy_Control_(H.)-Epithelial-KRT5-/KRT17+|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

LAMA3 WFDC3 EDIL3 TMPRSS6 RNF133

8.20e-071993953b1f56c8b40bb36922a31d2d440a8c468a8aa3f1
ToppCellBiopsy_Other_PF-Mesenchymal-Myofibroblasts|Biopsy_Other_PF / Sample group, Lineage and Cell type

CCN4 LTBP2 FBN1 EDIL3 LTBP4

8.41e-07200395e504570fd7eec1524c401b1cfa9d10822d80d994
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SCARF1 TENM1 FBN2 CLCN3

1.15e-05160394636127753e3a22831f39d4c8170df40901e4329d
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SCARF1 TENM1 FBN2 CLCN3

1.15e-05160394cb8d0dc1a6c69c7a85c5fdd8f0f6cca1b73dfc63
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 FBN2 EDIL3 LTBP4

1.43e-05169394c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellAT1-AT2_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

LAMA3 WFDC3 IGSF1 TMPRSS6

1.53e-051723940be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCellE15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

IZUMO1 EGFL8 LTBP4 TMPRSS6

1.56e-05173394b0ff9808e38cb64a734ced498cd0546728746cd5
ToppCellfacs-Marrow-KLS-18m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TOGARAM2 IZUMO1 KLHDC7A TMPRSS6

1.56e-05173394295bfe1efa648173c2d5981025bc61c576baf53f
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 SPACA1 LTBP4 TMPRSS6

1.60e-051743941d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCN4 LTBP2 FBN1 LTBP4

1.64e-051753941799a7be623dc3bf53ba580a7c47d2619969d708
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCN4 LTBP2 FBN1 LTBP4

1.64e-05175394795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EGFL8 SPACA1 OGG1 CHD5

1.79e-05179394c7c74e26bbf86c5326ee38bac7de111d5414f46b
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS16 CCN4 FBN1 EDIL3

1.83e-05180394935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCell5'-Airway_Nasal-Mesenchymal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS16 CCN4 FBN1 EDIL3

1.83e-051803943dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCellmetastatic_Brain-Fibroblasts-Myofibroblasts|metastatic_Brain / Location, Cell class and cell subclass

LTBP2 FBN1 FBN2 ADAM22

1.87e-05181394bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 ADAMTS18 FBN2 EDIL3

1.87e-051813945f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 ADAMTS18 FBN2 EDIL3

1.87e-05181394c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS16 CCN4 FBN1 EDIL3

1.95e-051833946d98973098c6d20c5305bce6a83a549a7d8dbfba
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCN4 FBN1 LTBP4 TMPRSS6

1.95e-051833947e5c467fd1b156b928f1611a12ab4affb9f714b7
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS16 CCN4 FBN1 EDIL3

1.95e-05183394cc7f5a17b40e8d901885174922e5fa8877643071
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS16 CCN4 FBN1 EDIL3

1.95e-05183394803376f5260de83c48d4f7301278d078a32b3e6e
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCN4 FBN1 LTBP4 TMPRSS6

1.95e-0518339463294d66e3ccf152ffe5d1237106764c14390b62
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS16 TENM1 FBN2 ZAN

1.99e-05184394ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS16 TENM1 FBN2 ZAN

1.99e-051843942cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS16 TENM1 FBN2 ZAN

1.99e-051843942b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Tuft|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS18 KLHDC7A C2CD4C TMPRSS6

2.03e-05185394686ed7550c6acd18e71e0076936ec5b07389adbd
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CCN4 FBN1 FBN2 LTBP4

2.08e-05186394c0a036096c2cb23305605b8aaf18869d6e0fb512
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS18 KLHDC7A IGSF1 TMPRSS6

2.08e-05186394ac7a84b11b4550c4ac01eab370dc8ab88e4fb72b
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCN4 FBN1 FBN2 LTBP4

2.08e-0518639494d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCN4 LTBP2 FBN1 LTBP4

2.08e-051863945473283fb95cee556b1f6934cf72169b676b5bcc
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

LTBP2 FBN1 FBN2 LTBP4

2.12e-051873945258674d0346e5c51a4b965efcdc1790c970845d
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

SLC5A9 LTBP2 FBN1 LTBP4

2.12e-051873944ea486991f66c29728d127171a07b81404ec0b78
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

ADAMTS16 CCN4 LTBP2 FBN1

2.12e-05187394a96495803ba13fcfadd1d83b3cf5774f3fed0a20
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS16 LTBP2 FBN1 LTBP4

2.17e-05188394e18065bbc26d6f3774fd1f478fb41d8fb555fa26
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCN4 FBN1 LTBP4 TMPRSS6

2.21e-05189394378f26f751ab4b470948c35dd8347de72dd12ff7
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCN4 FBN1 LTBP4 TMPRSS6

2.21e-05189394f0a2d4ef9896d764971ebbc6952510c128bb76e8
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS16 LTBP2 FBN1 LTBP4

2.21e-05189394d531399749409d614adca13d181830c6e3287508
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCN4 FBN1 FBN2 LTBP4

2.26e-05190394947807863a9b247c301c6cf63d6fd5a2c8018e66
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-mesenchymal_stem_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LTBP2 FBN1 LTBP4 TMPRSS6

2.26e-05190394d13fd234caa3fc69d8a59bc0060cdacdf716ee55
ToppCellP07|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CCN4 LTBP2 FBN1 EDIL3

2.26e-0519039438a613a9bca0ba040c3ada00286d1ce6f83ab23a
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast|PND07-28-samps / Age Group, Lineage, Cell class and subclass

LTBP2 FBN1 TMTC3 LTBP4

2.30e-051913949bbafdf316c1fa3a9f1ee30d41dd7158b5c97279
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCN4 FBN1 FBN2 LTBP4

2.30e-05191394db4943dd19207663fb9e27f8940fa4b06a933625
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CCN4 LTBP2 FBN1 EDIL3

2.30e-0519139404c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCN4 LTBP2 FBN1 LTBP4

2.30e-051913940fae1c2ef9f83ac7721d0a9d69455bf97eed9257
ToppCellmetastatic_Lymph_Node-Fibroblasts-Myofibroblasts|metastatic_Lymph_Node / Location, Cell class and cell subclass

ADAMTS16 CCN4 LTBP2 FBN1

2.30e-05191394aa43b472bc8362f79ae63f09f1ca764718bbf22c
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

CCN4 FBN1 EDIL3 LTBP4

2.30e-0519139478c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCellASK440-Mesenchymal-Fibroblast|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

TENM1 LTBP2 FBN1 LTBP4

2.30e-05191394387296b5377ef6839f0812e5b3529a10b5f7d530
ToppCellASK440-Mesenchymal|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

TENM1 LTBP2 FBN1 LTBP4

2.30e-05191394f12959eebb4167e1aa03de05d7711a702c58b3c9
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA3 FBN1 EGFL8 LTBP4

2.30e-05191394b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCN4 LTBP2 FBN1 LTBP4

2.40e-05193394dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCN4 LTBP2 FBN1 LTBP4

2.40e-05193394e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CCN4 LTBP2 FBN1 LTBP4

2.45e-0519439402b8102be9414d6964cd71019613edff6d88b893
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CCN4 LTBP2 FBN1 LTBP4

2.45e-0519439429f83cdd63314fff41258937d70b881a5503bfcc
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CCN4 LTBP2 FBN1 LTBP4

2.45e-05194394d3db241ea316bbcde6d16618193b474591ad5ce4
ToppCell18-Distal-Mesenchymal-Mesenchyme_SERPINF1-high|Distal / Age, Tissue, Lineage and Cell class

LTBP2 FBN1 FBN2 LTBP4

2.50e-05195394f86737bff21d81673238813df61a15cfe88d0b15
ToppCellwk_08-11-Mesenchymal-Fibroblast-Adventitial_fibro|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ADAMTS16 FBN1 FBN2 LTBP4

2.55e-05196394eed9fe83ffc1f79493b70778962a671dd9f481e0
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCN4 FBN1 EDIL3 LTBP4

2.55e-051963942ab9735aa7a7e95dcf6b0bdf0427f7b57f6349ee
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TENM1 CCN4 LTBP2 FBN1

2.60e-0519739444673c38384453207871d3fd8e8ba9093cc06bc5
ToppCellPND14-Mesenchymal|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCN4 LTBP2 FBN1 LTBP4

2.60e-051973949a14bc2e7d6081e2ab0e2e5555fc8804f13d3dbe
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCN4 LTBP2 FBN1 LTBP4

2.60e-051973944cf4e9553397cd8dee883dbec24f41bec41aff99
ToppCellPND03-Mesenchymal|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCN4 LTBP2 FBN1 LTBP4

2.60e-05197394e3053ef8f604b6892c21c03e12612b49d3d30f23
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCN4 FBN2 EDIL3 LTBP4

2.60e-051973941da8ba5bbab232add6e43ad78b15c2339d0c2bc3
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCN4 LTBP2 FBN1 FBN2

2.60e-05197394155e63b33302a87393ace699b2f6d73abe9c5763
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCN4 LTBP2 FBN1 FBN2

2.65e-051983940993d6895c0e4f360998ce35abea4ec3dd13e048
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCN4 LTBP2 FBN1 FBN2

2.65e-05198394a699b365d3b6149f13f02b2e2ae9b6fdce761848
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCN4 FBN2 EDIL3 LTBP4

2.65e-051983944a4566f86c9365a41b4cfd1609eac09bd73b3f34
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCN4 LTBP2 FBN1 FBN2

2.65e-05198394a4005a49cf6709b543994ceb51ecd5dc46197fa9
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ADAMTS16 CCN4 LTBP2 FBN1

2.65e-051983947d2fe57e0f9311ac1e6854402ebc154306eb1ba5
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TENM1 LTBP2 FBN1 LTBP4

2.71e-05199394e1f1950d6f840485e263b83dc81b98910be3ae7a
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 FBN2 EDIL3 LTBP4

2.71e-0519939430ab0750d51f168b18c434c974d24a4e70f29cc7
ToppCelldistal-mesenchymal-Myofibroblast-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CCN4 LTBP2 IGSF1 LTBP4

2.71e-0519939479917b5225cb45b4a0ea937f79f1752346e4346e
ToppCellILEUM-inflamed-(8)_Fibroblasts|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FBN1 EDIL3 LTBP4 DDX11

2.71e-051993943a3e2bb21cd0293622b1a975263e918d9ba24265
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 FBN2 EDIL3 LTBP4

2.71e-0519939484545ced0c792bc77980a50d65e484eab648d47e
ToppCellmetastatic_Brain-Fibroblasts-FB-like_cells|metastatic_Brain / Location, Cell class and cell subclass

CCN4 LTBP2 FBN1 ADAM22

2.71e-0519939412133087eae9f0e9b6c13a71e8187117768e64ce
ToppCellBiopsy_Control_(H.)-Mesenchymal-Myofibroblasts|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

CCN4 LTBP2 FBN1 LTBP4

2.71e-051993947a227c239afdaebcac84644d9b2653a5f1a4be71
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

LTBP2 FBN1 LTBP4 ADAM22

2.71e-051993946b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCellwk_15-18-Mesenchymal-Fibroblast-Adventitial_fibro|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ADAMTS16 FBN1 FBN2 LTBP4

2.71e-051993948de6d7b2067b22cb9b5f01aa56a3803aebc4406d
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 FBN2 EDIL3 LTBP4

2.71e-05199394e78f661b40da34768469549b6e755d330be6bbd8
ToppCellILEUM-non-inflamed-(8)_Fibroblasts|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FBN1 EDIL3 LTBP4 DDX11

2.71e-05199394d9d7f36b4b5592b7855448730044c90997b55499
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCN4 FBN2 EDIL3 LTBP4

2.71e-05199394137ff58897e6ada8a5a70205f66fe9110795506b
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS16 LTBP2 FBN1 LTBP4

2.71e-051993944e128c705ad36fd840582848f278770f356fcc8b
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

LTBP2 FBN1 LTBP4 ADAM22

2.71e-0519939438cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCellILEUM-non-inflamed-(8)_Fibroblast-(8)_Fibroblasts|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FBN1 EDIL3 LTBP4 DDX11

2.71e-0519939456d72da6a5fab9cbb2975fe6f87a631debaba6a8
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCN4 FBN1 FBN2 LTBP4

2.76e-052003943dacd0afe69bc16bb33336ea9ea99a9cd47731d9
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_only / Treatment groups by lineage, cell group, cell type

LTBP2 FBN1 LTBP4 ADAM22

2.76e-05200394a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCellBiopsy_IPF-Mesenchymal|Biopsy_IPF / Sample group, Lineage and Cell type

ADAMTS16 LTBP2 FBN1 LTBP4

2.76e-05200394bb605b373caf3f873dc1b87d712704568e0d6040
ToppCellcellseq-Mesenchymal-Myocytic-Myocytic_2-SCMF|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CCN4 LTBP2 FBN1 LTBP4

2.76e-05200394b441b3771fb7d9ee7b7a104afc35e466aace2da2
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS16 LTBP2 FBN1 LTBP4

2.76e-052003943e6730c9ed7003a4acf501f699a4965a7a50f946
Drugfuniferine N-oxide

LTBP2 FBN1 FBN2 LTBP4

1.47e-0649394CID000191631
DrugMedrysone [2668-66-8]; Up 200; 11.6uM; PC3; HT_HG-U133A

SPACA1 LTBP4 ADAM22 TMPRSS6 CHD5

2.04e-051963953705_UP
DrugSulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A

MTMR3 LTBP2 FBN1 LTBP4 TMPRSS6

2.04e-051963953847_UP
DrugCyclacillin [3485-14-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A

SCARF1 FBN2 LTBP4 TMPRSS6 CHD5

2.14e-051983954358_UP
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2

4.84e-063382DOID:65 (implicated_via_orthology)
DiseaseWeill-Marchesani syndrome

LTBP2 FBN1

4.84e-063382C0265313
DiseaseWeill-Marchesani Syndrome, Autosomal Dominant

LTBP2 FBN1

4.84e-063382C1869115
DiseaseWeill-Marchesani Syndrome, Autosomal Recessive

LTBP2 FBN1

4.84e-063382C1869114
DiseaseWeill-Marchesani syndrome

LTBP2 FBN1

9.67e-064382cv:C0265313
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

9.67e-064382DOID:0060249 (is_implicated_in)
DiseaseWeill-Marchesani syndrome (is_implicated_in)

LTBP2 FBN1

9.67e-064382DOID:0050475 (is_implicated_in)
DiseaseMarfan Syndrome

LTBP2 FBN1

8.82e-0511382C0024796
Diseaseferritin measurement

TOGARAM2 MS4A4A TMPRSS6

4.87e-04119383EFO_0004459
DiseaseStevens-Johnson syndrome, toxic epidermal necrolysis, response to cold medicine

IKZF1 LTBP2

1.05e-0337382EFO_0004276, EFO_0004775, EFO_0006997
DiseaseLymphoma

IKZF1 OGG1

1.22e-0340382C0024299

Protein segments in the cluster

PeptideGeneStartEntry
EAICAKPCLNGGVCV

EGFL8

111

Q99944
CEVCQQGGEIILCDT

CHD5

346

Q8TDI0
GTPAECVLEGAECCK

ADAM22

461

Q9P0K1
CIDGAVGCTPLCLRV

CCN4

146

O95388
SINCCVGLCLVPGKL

C2CD4C

341

Q8TF44
VCIDGICERVGCDNV

ADAMTS16

711

Q8TE57
KNDVCIDGVCELVGC

ADAMTS18

711

Q8TE60
CPVCDQKVVLAEAAG

TRIM71

91

Q2Q1W2
VCDPGTGACLCKENV

LAMA3

1416

Q16787
KLKCDICGIICIGPN

IKZF1

116

Q13422
CILPGVGTKVADCIC

OGG1

241

O15527
ILCNLCGVVPGGVVC

DDX11

691

Q96FC9
NECEVEPCKNGGICT

EDIL3

121

O43854
CCGLCNGVLIEETEI

IGSF1

571

Q8N6C5
VDECEKNPCAGGECI

FBN1

491

P35555
GCKVLCCTPGGVVLI

MS4A4A

206

Q96JQ5
VNECLTPGVCAHGKC

LTBP2

1011

Q14767
VLCPLICHNGGVCVK

LTBP4

151

Q8N2S1
VADVCPKEDSGGLCC

KLHDC7A

496

Q5VTJ3
ALAGCLLPAEGCVIC

IZUMO1

11

Q8IYV9
ECKEIPGICANGVCI

FBN2

1811

P35556
ISCDLIGCPLVCGAV

FBXO30

26

Q8TB52
CPGGESKCVVRVEEC

SPACA1

101

Q9HBV2
ALPLAECKEGLVCNG

MTMR3

916

Q13615
GTCPICKCDILKVLG

RNF133

291

Q8WVZ7
VVCENGLPIKEGLSC

TOGARAM2

731

Q6ZUX3
CILKCEGTGVCVLTG

SHCBP1L

501

Q9BZQ2
EVGCVDPDVCQRICG

SLC5A9

346

Q2M3M2
VCICVPGYKGEICEE

TENM1

611

Q9UKZ4
ICEGPDACQKDEVCV

SCARF1

56

Q14162
KEGPLVHVACCCGNI

CLCN3

281

P51790
GDELCPAEQKCCTTG

WFDC3

46

Q8IUB2
HGNIVKNCCEVLCGP

ZDHHC9

276

Q9Y397
CLCAGAKPKLICEGN

PYROXD1

111

Q8WU10
VEEEGLQICVEICGC

ZNF654

346

Q8IZM8
DGEVLKPQCIICGDV

ZBED9

751

Q6R2W3
LCKEQGITVVGICCV

TMTC3

186

Q6ZXV5
GDIPCICKECGKVFI

ZNF175

331

Q9Y473
VNGLCVPACDGVKDC

TMPRSS6

466

Q8IU80
EGAKVPSACAEGCIC

ZAN

2236

Q9Y493