Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	neurexin family protein binding	NLGN4X NLGN4Y NLGN1	3.22e-05	16	79	3	GO:0042043
GeneOntologyBiologicalProcess	presynaptic membrane assembly	NLGN4X NLGN4Y NLGN1	6.12e-06	10	78	3	GO:0097105
GeneOntologyBiologicalProcess	postsynaptic membrane assembly	NLGN4X NLGN4Y NLGN1	8.40e-06	11	78	3	GO:0097104
GeneOntologyBiologicalProcess	presynaptic membrane organization	NLGN4X NLGN4Y NLGN1	1.45e-05	13	78	3	GO:0097090
GeneOntologyBiologicalProcess	male mating behavior	NLGN4X NLGN4Y GRIN1	2.29e-05	15	78	3	GO:0060179
GeneOntologyBiologicalProcess	neuron cell-cell adhesion	NLGN4X NLGN4Y NLGN1	2.81e-05	16	78	3	GO:0007158
GeneOntologyBiologicalProcess	territorial aggressive behavior	NLGN4X NLGN4Y	4.23e-05	3	78	2	GO:0002124
GeneOntologyBiologicalProcess	male courtship behavior	NLGN4X NLGN4Y	8.43e-05	4	78	2	GO:0008049
GeneOntologyBiologicalProcess	neurotransmitter receptor transport postsynaptic membrane to endosome	MKLN1 SCRIB	8.43e-05	4	78	2	GO:0098968
GeneOntologyBiologicalProcess	hindbrain development	NLGN4X NLGN4Y SPTBN2 SMARCA4 GRIN1 SCRIB	1.37e-04	208	78	6	GO:0030902
GeneOntologyBiologicalProcess	olfactory learning	GRIN1 ADCY3	1.40e-04	5	78	2	GO:0008355
GeneOntologyBiologicalProcess	synaptic vesicle targeting	NLGN1 SCRIB	1.40e-04	5	78	2	GO:0016080
GeneOntologyBiologicalProcess	learning	NLGN4X MTOR NLGN4Y UBA6 GRIN1 ADCY3	1.52e-04	212	78	6	GO:0007612
GeneOntologyBiologicalProcess	social behavior	NLGN4X MTOR NLGN4Y GRIN1	1.78e-04	74	78	4	GO:0035176
GeneOntologyBiologicalProcess	biological process involved in intraspecies interaction between organisms	NLGN4X MTOR NLGN4Y GRIN1	1.97e-04	76	78	4	GO:0051703
GeneOntologyBiologicalProcess	metencephalon development	NLGN4X NLGN4Y SPTBN2 GRIN1 SCRIB	2.87e-04	153	78	5	GO:0022037
GeneOntologyBiologicalProcess	courtship behavior	NLGN4X NLGN4Y	2.93e-04	7	78	2	GO:0007619
GeneOntologyBiologicalProcess	brain development	SETD2 NLGN4X NLGN4Y SPTBN2 ASPM UBA6 SMARCA4 IRS2 GRIN1 SCRIB TUBGCP2	3.72e-04	859	78	11	GO:0007420
GeneOntologyBiologicalProcess	brainstem development	NLGN4X NLGN4Y	3.90e-04	8	78	2	GO:0003360
GeneOntologyBiologicalProcess	postsynapse assembly	NLGN4X NLGN4Y SPTBN2 NLGN1	4.28e-04	93	78	4	GO:0099068
GeneOntologyCellularComponent	symmetric synapse	NLGN4X NLGN4Y MKLN1	1.45e-05	13	79	3	GO:0032280
GeneOntologyCellularComponent	excitatory synapse	NLGN4X NLGN4Y SPTBN2 GRIN1 NLGN1	5.33e-05	107	79	5	GO:0060076
GeneOntologyCellularComponent	glycinergic synapse	NLGN4X NLGN4Y EIF2B2	5.65e-05	20	79	3	GO:0098690
GeneOntologyCellularComponent	symmetric, GABA-ergic, inhibitory synapse	NLGN4X NLGN4Y	8.42e-05	4	79	2	GO:0098983
GeneOntologyCellularComponent	asymmetric, glutamatergic, excitatory synapse	NLGN4X NLGN4Y NLGN1	9.93e-05	24	79	3	GO:0098985
GeneOntologyCellularComponent	postsynaptic specialization membrane	NLGN4X NLGN4Y MKLN1 GRIN1 NLGN1 SCRIB	1.14e-04	201	79	6	GO:0099634
GeneOntologyCellularComponent	Mon1-Ccz1 complex	CCZ1B CCZ1	1.40e-04	5	79	2	GO:0035658
GeneOntologyCellularComponent	inhibitory synapse	NLGN4X NLGN4Y NLGN1	2.16e-04	31	79	3	GO:0060077
GeneOntologyCellularComponent	postsynaptic membrane	NLGN4X NLGN4Y MKLN1 CACNA1H GRIN1 NLGN1 SCRIB	8.51e-04	405	79	7	GO:0045211
GeneOntologyCellularComponent	PML body	MAGEA4 MAGEA6 UBN1 MTOR	1.30e-03	125	79	4	GO:0016605
GeneOntologyCellularComponent	postsynapse	NLGN4X MTOR NLGN4Y SPTBN2 EIF2B2 MKLN1 CACNA1H GRIN1 NLGN1 SCRIB RPL7	1.50e-03	1018	79	11	GO:0098794
Domain	Nlgn	NLGN4X NLGN4Y NLGN1	7.52e-07	5	80	3	IPR000460
Domain	DUF1712	CCZ1B CCZ1	1.81e-05	2	80	2	PF08217
Domain	NLGN4	NLGN4X NLGN4Y	1.81e-05	2	80	2	IPR030025
Domain	DUF1712_fun	CCZ1B CCZ1	1.81e-05	2	80	2	IPR013176
Domain	Carboxylesterase_B_CS	NLGN4X NLGN4Y NLGN1	2.10e-05	13	80	3	IPR019819
Domain	CARBOXYLESTERASE_B_2	NLGN4X NLGN4Y NLGN1	2.66e-05	14	80	3	PS00941
Domain	COesterase	NLGN4X NLGN4Y NLGN1	2.66e-05	14	80	3	PF00135
Domain	CarbesteraseB	NLGN4X NLGN4Y NLGN1	2.66e-05	14	80	3	IPR002018
Domain	TPR_1	TOMM70 SPAG1 CDC16 TOMM34 TTC9	4.20e-05	90	80	5	PF00515
Domain	TPR_1	TOMM70 SPAG1 CDC16 TOMM34 TTC9	4.20e-05	90	80	5	IPR001440
Domain	TPR	TOMM70 SPAG1 CDC16 TOMM34 TTC9	2.31e-04	129	80	5	SM00028
Domain	-	TOMM70 SPAG1 MTOR CDC16 TOMM34 TTC9	2.62e-04	207	80	6	1.25.40.10
Domain	TPR_repeat	TOMM70 SPAG1 CDC16 TOMM34 TTC9	2.66e-04	133	80	5	IPR019734
Domain	TPR-contain_dom	TOMM70 SPAG1 CDC16 TOMM34 TTC9	4.63e-04	150	80	5	IPR013026
Domain	TPR-like_helical_dom	TOMM70 SPAG1 MTOR CDC16 TOMM34 TTC9	4.92e-04	233	80	6	IPR011990
Domain	TPR_REGION	TOMM70 SPAG1 CDC16 TOMM34 TTC9	7.14e-04	165	80	5	PS50293
Domain	TPR	TOMM70 SPAG1 CDC16 TOMM34 TTC9	7.14e-04	165	80	5	PS50005
Domain	PH	ASAP2 MYO10 SPTBN2 IRS2 SKAP2	3.02e-03	229	80	5	PF00169
Domain	MAGE_N	MAGEA4 MAGEA6	3.27e-03	20	80	2	SM01392
Domain	MAGE_N	MAGEA4 MAGEA6	3.96e-03	22	80	2	PF12440
Domain	MAGE_N	MAGEA4 MAGEA6	3.96e-03	22	80	2	IPR021072
Domain	AMP-binding_CS	ACSL4 ACSM4	5.51e-03	26	80	2	IPR020845
Domain	AMP_BINDING	ACSL4 ACSM4	6.37e-03	28	80	2	PS00455
Domain	PH	ASAP2 MYO10 SPTBN2 IRS2 SKAP2	6.84e-03	278	80	5	SM00233
Domain	PH_DOMAIN	ASAP2 MYO10 SPTBN2 IRS2 SKAP2	6.94e-03	279	80	5	PS50003
Domain	PH_domain	ASAP2 MYO10 SPTBN2 IRS2 SKAP2	7.04e-03	280	80	5	IPR001849
Domain	AMP-binding	ACSL4 ACSM4	7.29e-03	30	80	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSL4 ACSM4	7.29e-03	30	80	2	IPR000873
Pubmed	Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.	NLGN4X NLGN4Y GRIN1 NLGN1	3.65e-08	15	81	4	18227507
Pubmed	Analysis of four neuroligin genes as candidates for autism.	NLGN4X NLGN4Y NLGN1	4.86e-08	4	81	3	16077734
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	CCZ1B UBN1 CCZ1 CDC16 POLE ANXA11 SMARCA4 CDC73 SCRIB TUBGCP2 HNRNPR	1.10e-07	582	81	11	20467437
Pubmed	Synapse formation: if it looks like a duck and quacks like a duck ...	NLGN4X NLGN4Y NLGN1	1.21e-07	5	81	3	10996085
Pubmed	Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.	NLGN4X NLGN4Y NLGN1	1.21e-07	5	81	3	37865312
Pubmed	The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?	NLGN4X NLGN4Y NLGN1	2.42e-07	6	81	3	21838267
Pubmed	Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.	NLGN4X NLGN4Y NLGN1	2.42e-07	6	81	3	29724786
Pubmed	Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.	NLGN4X NLGN4Y NLGN1	6.76e-07	8	81	3	30871858
Pubmed	SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.	NLGN4X NLGN4Y NLGN1	1.98e-06	11	81	3	32973045
Pubmed	Behavioral phenotypes of genetic mouse models of autism.	NLGN4X NLGN4Y NLGN1	1.98e-06	11	81	3	26403076
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	ASAP2 NLGN4X MTOR NLGN4Y SPTBN2 GRIN1 NLGN1	4.35e-06	281	81	7	28706196
Pubmed	The associations of DNA methylation alterations in oxidative stress-related genes with cancer incidence and mortality outcomes: a population-based cohort study.	MTOR ALOXE3	5.36e-06	2	81	2	30678711
Pubmed	Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer.	ACSL4 MTOR	5.36e-06	2	81	2	26536660
Pubmed	Unusually rapid evolution of Neuroligin-4 in mice.	NLGN4X NLGN4Y	5.36e-06	2	81	2	18434543
Pubmed	Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.	NLGN4X NLGN4Y	5.36e-06	2	81	2	23183221
Pubmed	Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.	NLGN4X NLGN4Y	5.36e-06	2	81	2	24855039
Pubmed	Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder.	NLGN4X NLGN4Y	5.36e-06	2	81	2	37001827
Pubmed	Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice.	NLGN4X NLGN4Y	5.36e-06	2	81	2	37080762
Pubmed	Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex.	NLGN4X NLGN4Y	5.36e-06	2	81	2	29106499
Pubmed	Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.	NLGN4X NLGN4Y	5.36e-06	2	81	2	26456829
Pubmed	Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.	NLGN4X NLGN4Y	5.36e-06	2	81	2	24104404
Pubmed	A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.	NLGN4X NLGN4Y	5.36e-06	2	81	2	32243781
Pubmed	Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.	NLGN4X NLGN4Y	5.36e-06	2	81	2	22989184
Pubmed	Assembly of mTORC3 Involves Binding of ETV7 to Two Separate Sequences in the mTOR Kinase Domain.	MTOR ETV7	5.36e-06	2	81	2	39337528
Pubmed	Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens.	MAGEA4 MAGEA6	5.36e-06	2	81	2	7642112
Pubmed	Comparative Phosphoproteomic Profiling of Type III Adenylyl Cyclase Knockout and Control, Male, and Female Mice.	NDOR1 ADCY3	5.36e-06	2	81	2	30814930
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SETD2 HMCN2 CDC16 RHOBTB3 NOL12 ASPM SMARCA4 IRS2 SCRIB TUBGCP2 KAT6B INO80E	1.03e-05	1116	81	12	31753913
Pubmed	Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan.	NDOR1 MTOR	1.60e-05	3	81	2	25059582
Pubmed	PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.	CCZ1B CCZ1	1.60e-05	3	81	2	32160108
Pubmed	Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.	NLGN4X NLGN4Y	1.60e-05	3	81	2	32011705
Pubmed	Analysis of the neuroligin 4Y gene in patients with autism.	NLGN4X NLGN4Y	1.60e-05	3	81	2	18628683
Pubmed	Ablation of Type III Adenylyl Cyclase in Mice Causes Reduced Neuronal Activity, Altered Sleep Pattern, and Depression-like Phenotypes.	NDOR1 ADCY3	1.60e-05	3	81	2	26868444
Pubmed	Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity.	NDOR1 GRIN1	1.60e-05	3	81	2	16140270
Pubmed	Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.	NLGN4X NLGN4Y	1.60e-05	3	81	2	21282647
Pubmed	A protein interaction landscape of breast cancer.	DNAJB12 ACSL4 TOMM70 ANXA11 SPTBN2 SMARCA4 CDC73 RPL7 HNRNPR	1.71e-05	634	81	9	34591612
Pubmed	DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.	NLGN4X NLGN4Y NLGN1	3.04e-05	26	81	3	34848499
Pubmed	Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.	NLGN4X NLGN4Y	3.20e-05	4	81	2	12669065
Pubmed	Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons.	ACSM4 ADCY3	3.20e-05	4	81	2	24034253
Pubmed	Homodimerization and isoform-specific heterodimerization of neuroligins.	NLGN4X NLGN4Y	3.20e-05	4	81	2	22671294
Pubmed	Ultrasonic vocalizations in mouse models for speech and socio-cognitive disorders: insights into the evolution of vocal communication.	NLGN4X NLGN4Y	3.20e-05	4	81	2	20579107
Pubmed	MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.	NDOR1 MTOR	3.20e-05	4	81	2	23341605
Pubmed	Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.	NLGN4X NLGN4Y	3.20e-05	4	81	2	17292328
Pubmed	Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.	CCZ1B CCZ1	3.20e-05	4	81	2	20305638
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	ASAP2 MTOR POLE ANXA11 EIF2B2 SCRIB HNRNPR	4.23e-05	400	81	7	35013556
Pubmed	NMDA Receptors Regulate the Development of Neuronal Intrinsic Excitability through Cell-Autonomous Mechanisms.	MTOR GRIN1	5.33e-05	5	81	2	29163060
Pubmed	Cloning and analysis of MAGE-1-related genes.	MAGEA4 MAGEA6	5.33e-05	5	81	2	8037761
Pubmed	Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight.	NDOR1 ADCY3	5.33e-05	5	81	2	33938449
Pubmed	Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins.	NLGN4X NLGN1	5.33e-05	5	81	2	15620359
Pubmed	Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma.	SETD2 SMARCA4	5.33e-05	5	81	2	28202515
Pubmed	mTOR masters monocyte development in bone marrow by decreasing the inhibition of STAT5 on IRF8.	NDOR1 MTOR	5.33e-05	5	81	2	29463562
Pubmed	The TSC-mTOR pathway regulates macrophage polarization.	NDOR1 MTOR	5.33e-05	5	81	2	24280772
Pubmed	Neuroligins and neurexins link synaptic function to cognitive disease.	NLGN4X NLGN4Y	5.33e-05	5	81	2	18923512
Pubmed	Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.	NDOR1 MTOR	5.33e-05	5	81	2	22461615
Pubmed	Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR.	MTOR IRS2	5.33e-05	5	81	2	19561084
Pubmed	Defining the membrane proteome of NK cells.	PIGN DNAJB12 ACSL4 TOMM70 MTOR ANXA11 SMARCA4 TOMM34 TUBGCP2 ADCY3 RPL7	8.25e-05	1168	81	11	19946888
Pubmed	Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila.	KANSL2 MTOR	1.12e-04	7	81	2	16543150
Pubmed	HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5.	NDOR1 MTOR	1.12e-04	7	81	2	23103253
Pubmed	Energy balance, the PI3K-AKT-mTOR pathway genes, and the risk of bladder cancer.	MTOR IRS2	1.12e-04	7	81	2	20354165
Pubmed	MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation analysis in induced sputum from patients with lung cancer and non-malignant lung diseases.	MAGEA4 MAGEA6	1.12e-04	7	81	2	22134685
Pubmed	Expression of melanoma-associated antigens in oral squamous cell carcinoma.	MAGEA4 MAGEA6	1.12e-04	7	81	2	18197853
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	DNAJB12 MTOR SMARCA4 CDC73 SCRIB TUBGCP2 RPL7 HNRNPR	1.22e-04	638	81	8	33239621
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	DNAJB12 SETD2 UBN1 CDC16 POLE UBA6 SMARCA4 TOMM34 CDC73 NIT2	1.23e-04	1014	81	10	32416067
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ACSL4 SPAG1 SPTBN2 ASPM MYRIP TOP1MT ZBTB11 SKAP2 GSR PHTF1 HNRNPR MYBPC2	1.24e-04	1442	81	12	35575683
Pubmed	mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis.	NDOR1 MTOR	1.49e-04	8	81	2	29275959
Pubmed	Control of excitatory and inhibitory synapse formation by neuroligins.	GRIN1 NLGN1	1.49e-04	8	81	2	15681343
Pubmed	MAGE cancer-testis antigens protect the mammalian germline under environmental stress.	MAGEA4 MAGEA6	1.49e-04	8	81	2	31149633
Pubmed	The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice.	MAGEA4 MAGEA6	1.49e-04	8	81	2	27226137
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DNAJB12 ASAP2 NLGN4Y AFF3 MKLN1 NT5C2 MYRIP UBA6 CACNA1H KAT6B ADCY3 NIT2	1.67e-04	1489	81	12	28611215
Pubmed	Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.	NLGN4X NLGN4Y	1.91e-04	9	81	2	23010509
Pubmed	Microglia ablation alleviates myelin-associated catatonic signs in mice.	NLGN4X NLGN4Y	1.91e-04	9	81	2	29252214
Pubmed	Binding of neuroligins to PSD-95.	NLGN4X NLGN1	1.91e-04	9	81	2	9278515
Pubmed	The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2.	MTOR IRS2	2.38e-04	10	81	2	27742835
Pubmed	PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.	SETD2 CDC16 ASPM SMARCA4 HNRNPR	2.86e-04	247	81	5	32989298
Pubmed	Nuclear Functions of Nucleolin through Global Proteomics and Interactomic Approaches.	SMARCA4 CDC73 RPL7 HNRNPR	3.76e-04	145	81	4	27049334
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TOMM70 MYO10 CACNA1H NLGN1 SCRIB ADCY3	3.84e-04	407	81	6	12693553
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CCDC13 MTOR SPTBN2 NT5C2 UBA6 SMARCA4 GRIN1 CDC73 SCRIB	4.04e-04	963	81	9	28671696
Pubmed	Advancing the understanding of autism disease mechanisms through genetics.	NLGN4X NLGN4Y	4.11e-04	13	81	2	27050589
Pubmed	A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.	KANSL2 MTOR POLE ASPM RPL7 INO80E	4.47e-04	419	81	6	28700943
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SETD2 UBN1 ASPM EYA3 TUBGCP2 GSR HNRNPR	4.50e-04	588	81	7	38580884
Pubmed	The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28.	MAGEA4 MAGEA6	4.79e-04	14	81	2	8575766
Pubmed	Connexin Expression Is Altered in Liver Development of Yotari (dab1 -/-) Mice.	GJB2 MTOR	5.52e-04	15	81	2	34639052
Pubmed	Structure, chromosomal localization, and expression of 12 genes of the MAGE family.	MAGEA4 MAGEA6	5.52e-04	15	81	2	7927540
Pubmed	Hippocampals neurogenesis is impaired in mice with a deletion in the coiled coil domain of Talpid3-implications for Joubert syndrome.	NDOR1 ADCY3	5.52e-04	15	81	2	35470378
Pubmed	Mitochondrial Raf1 Regulates Glutamine Catabolism.	SPAG1 ANXA11 ASPM TOMM34 GSR	5.77e-04	288	81	5	38496616
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	SETD2 MTOR SMARCA4	6.21e-04	71	81	3	28319113
Pubmed	Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2-/- Mice.	MTOR GRIN1	6.29e-04	16	81	2	30466882
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DNAJB12 POLE TMEM126B SPTBN2 ASPM UBA6 TOMM34 SCRIB NFS1 RPL7 GSR	6.53e-04	1487	81	11	33957083
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	DNAJB12 CCZ1B TOMM70 CCZ1 POLE SMARCA4 SCRIB SKAP2 RPL7 HNRNPR	6.72e-04	1257	81	10	37317656
Pubmed	Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.	AFF3 PHTF1	7.12e-04	17	81	2	17554260
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CCDC13 KANSL2 RHOBTB3 SPTBN2 MKLN1 MYRIP SMARCA4 SCRIB EYA3 ZBTB11	7.95e-04	1285	81	10	35914814
Pubmed	Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.	MTOR SMARCA4	8.00e-04	18	81	2	33323119
Pubmed	Loss of transforming growth factor-beta 2 leads to impairment of central synapse function.	GRIN1 NLGN1	8.00e-04	18	81	2	18854036
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MTOR POLE ANXA11 SPTBN2 SMARCA4 ZBTB11 RPL7	8.33e-04	653	81	7	22586326
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SETD2 KANSL2 UBN1 TBRG1 CDC16 SMARCA4 CDC73 RPL7 HNRNPR INO80E	8.39e-04	1294	81	10	30804502
Pubmed	Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation.	MTOR SMARCA4	8.93e-04	19	81	2	27246713
Pubmed	An Ideal PPAR Response Element Bound to and Activated by PPARα.	MTOR ALOXE3	9.91e-04	20	81	2	26241474
Pubmed	Establishment of totipotency does not depend on Oct4A.	SMARCA4 UTF1	9.91e-04	20	81	2	23934214
Pubmed	Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.	ACSL4 MTOR IRS2 RPL7	1.03e-03	190	81	4	15161933
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	ACSL4 MAGEA4 TOMM70 SPAG1 MTOR ANXA11 UBA6 TOMM34 SCRIB RPL7	1.27e-03	1367	81	10	32687490
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	MTOR POLE ANXA11 SMARCA4 TOMM34 CDC73 SCRIB	1.29e-03	704	81	7	29955894
Cytoband	3q12.2	TOMM70 NIT2	1.13e-04	9	82	2	3q12.2
Cytoband	Ensembl 112 genes in cytogenetic band chr3q12	TOMM70 ZBTB11 NIT2	1.28e-04	54	82	3	chr3q12
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TOMM70 SPAG1 CDC16 TOMM34 TTC9	3.07e-05	115	57	5	769
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ASAP2 MYO10 SPTBN2 IRS2 SKAP2	4.73e-04	206	57	5	682
GeneFamily	Acyl-CoA synthetase family	ACSL4 ACSM4	3.02e-03	26	57	2	40
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 ASAP2 MYO10 SPTBN2 EYA3 PDE7B	1.32e-06	188	82	6	e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 ASAP2 MYO10 SPTBN2 EYA3 PDE7B	1.41e-06	190	82	6	11d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCell	Severe-B_naive-8\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	AFF3 IRS2 PIWIL3 UTF1 MYBPC2	7.25e-06	145	82	5	a24cad86509208bc7267b02ef1d1b0a25a2a7043
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 ASAP2 RHOBTB3 SPTBN2 EYA3	2.23e-05	183	82	5	d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 ASAP2 SPTBN2 EYA3 RPL7	2.29e-05	184	82	5	9690d4290e70f9bda889754ffb30b0af1f7cb94b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 ASAP2 MYO10 SPTBN2 EYA3	2.35e-05	185	82	5	3d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 ASAP2 RHOBTB3 SPTBN2 EYA3	2.41e-05	186	82	5	08632045d499e61dd96ff29a5a9a208afe58dc58
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 ASAP2 RHOBTB3 SPTBN2 EYA3	2.41e-05	186	82	5	b3358e0fa6d845c81e94d56c8575f016621d28ff
ToppCell	10x5'-Lung-Mast\|Lung / Manually curated celltypes from each tissue	ACSL4 MYO10 RHOBTB3 MYRIP PDE7B	2.48e-05	187	82	5	f8ac5ca5cbe9c6f3d8c0fffc20fe08ca1aea43c0
ToppCell	10x5'-Lung-Mast-Mast_cells\|Lung / Manually curated celltypes from each tissue	ACSL4 MYO10 RHOBTB3 MYRIP PDE7B	2.48e-05	187	82	5	da275d2c774b3e6a8ed77f777dd0676ecf2ddd2c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 ASAP2 RHOBTB3 SPTBN2 EYA3	2.60e-05	189	82	5	8ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 ASAP2 MYO10 SPTBN2 EYA3	2.60e-05	189	82	5	a9864873b19ab3e60acf11f288fa7275badc2e42
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 MYO10 SPTBN2 EYA3 PDE7B	2.67e-05	190	82	5	b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCell	COVID-19-kidney-CD-PC\|kidney / Disease (COVID-19 only), tissue and cell type	SLC9A4 ASAP2 RHOBTB3 SPTBN2 EYA3	2.88e-05	193	82	5	738689d009e4b118d7ce3171a207294b95cbe78b
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 ASAP2 RHOBTB3 SPTBN2 EYA3	2.88e-05	193	82	5	d994b2f2707877288f88cab7cd6002ef91962c50
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_granulocytic-basophil\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ACSL4 MYO10 RHOBTB3 ANXA11 ZNF445	2.95e-05	194	82	5	aca009b9f1f320c0a65ea16df6595d7ede0b1fda
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 ASAP2 RHOBTB3 SPTBN2 EYA3	3.02e-05	195	82	5	3f517c6fc372bdcaf45b3af373414f13cbebd4ba
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 ASAP2 RHOBTB3 SPTBN2 EYA3	3.02e-05	195	82	5	e94bac6a5c788ee160d7feaf2a3c512a3691f995
Drug	Mefloquine hydrochloride [51773-92-3]; Down 200; 9.6uM; MCF7; HT_HG-U133A	SETD2 MTOR CDC16 ANXA11 UBA6 TUBGCP2 KAT6B	5.77e-06	193	81	7	6205_DN
Drug	Carbenoxolone disodium salt [7421-40-1]; Down 200; 6.6uM; MCF7; HT_HG-U133A	PIGN DNAJB12 MYO10 ALOXE3 TTC9 TUBGCP2 KAT6B	5.77e-06	193	81	7	4173_DN
Drug	(-) -Levobunolol hydrochloride [27912-14-7]; Down 200; 12.2uM; MCF7; HT_HG-U133A	DNAJB12 NDOR1 STAB2 MYO10 SPTBN2 TTC9 KAT6B	5.97e-06	194	81	7	4134_DN
Disease	neuroligin-1 measurement	STAB2 NLGN1	2.12e-05	3	79	2	EFO_0802802
Disease	Intellectual Disability	SETD2 MTOR AFF3 NT5C2 GRIN1 ZBTB11 HNRNPR	1.98e-04	447	79	7	C3714756
Disease	interleukin 18 receptor accessory protein measurement	SLC9A4 TNXB	2.52e-04	9	79	2	EFO_0008179
Disease	Carcinoma, Small Cell	MTOR SMARCA4	2.52e-04	9	79	2	C0262584
Disease	kidney cancer (implicated_via_orthology)	POLE SCRIB	3.83e-04	11	79	2	DOID:263 (implicated_via_orthology)
Disease	Hermansky-Pudlak syndrome (implicated_via_orthology)	CCZ1B CCZ1	6.31e-04	14	79	2	DOID:3753 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	NLGN4X NLGN4Y GRIN1 NLGN1	7.53e-04	152	79	4	DOID:0060041 (implicated_via_orthology)
Disease	cancer (implicated_via_orthology)	MTOR POLE SMARCA4 SCRIB TOP1MT	7.76e-04	268	79	5	DOID:162 (implicated_via_orthology)
Disease	Liver carcinoma	ACSL4 MAGEA6 STAB2 MTOR ASPM IRS2	2.41e-03	507	79	6	C2239176

Protein segments in the cluster

Peptide	Gene	Start	Entry
FRLKRDHAVKYSKAL	AFF3	1076	P51826
TDAFKLKRKELRNHY	ACSL4	686	O60488
HIRELNRAYKAEFKK	ANXA11	306	P50995
AKIKAFHLKYDEVRL	CDC73	471	Q6P1J9
KHALKKYRREAYHRV	NT5C2	21	P49902
RKLAHRLFEYKEDSK	GSR	391	P00390
DLKRYKFKSLRHCLT	ACSM4	331	P0C7M7
AYRRHEKKRKFIKGE	GJB2	96	P29033
KAFKIRKHYLHLRAT	ASPM	2636	Q8IZT6
FLEREVYRVKKKYHI	MSANTD5	51	A0A3B3IT52
LYISDADKRKHFRLV	RBPJL	156	Q9UBG7
KRREYLTGFHKRKVE	NOL12	26	Q9UGY1
AFRYRKVREIYDKHK	EYA3	416	Q99504
KDKVEFYRKLHAVAA	GPR141	121	Q7Z602
LLHEKAAQIKRRYAK	KAT6B	326	Q8WYB5
YRKIFVGRFKSHKER	PABPC1L2A	156	Q5JQF8
ELAHFLLRKYRAKEL	MAGEA4	116	P43358
RKVAKLVHFLLLKYR	MAGEA6	111	P43360
KGVARFYRSRKKHLI	NFS1	136	Q9Y697
IAIHKARYYKRKDGL	HDHD2	141	Q9H0R4
ARAKDYHKKEELLRL	HMCN2	141	Q8NDA2
LLRVHKERYAFFRKD	ALOXE3	66	Q9BYJ1
ITAKYIERRYARKKH	ASAP2	526	O43150
TYLKVLKVARFHCKR	GPR26	191	Q8NDV2
KKKVKRLLSFQRYFH	PDE7B	66	Q9NP56
KLERVKKLKDYAFVH	HNRNPR	366	O43390
LKYLKFHLKRIREQF	MYO10	1646	Q9HD67
KKKYHSYLERKRRND	MYCLP1	276	P12525
EKELVAHLRSIKRYF	TUBGCP2	506	Q9BSJ2
RRLADYCRKAYKKIH	POLE	721	Q07864
ALYYKKDKRRHDVHR	NLGN1	736	Q8N2Q7
RRKLIYEKAKHYHKE	RPL7	46	P18124
CHKKFRRQAYLRKHL	INSM2	431	Q96T92
SYAKFNFVAKKLHRR	NDOR1	101	Q9UHB4
RNLKRKLKFLIYEHE	INO80E	16	Q8NBZ0
YLRKQKHGHKRFFVL	IRS2	36	Q9Y4H2
LAFAALYYKKDKRRH	NLGN4Y	691	Q8NFZ3
RTRIYHKLKHFKFKL	CCDC82	471	Q8N4S0
RKLKKYAEALDYHRQ	CDC16	456	Q13042
RALRHYYKLNIIKKE	ETV7	281	Q9Y603
LKKAYRRLALKFHPD	DNAJB12	126	Q9NXW2
RLYKLLKERDFEIKH	CCDC13	96	Q8IYE1
VKLLKERLEKFFHRY	CCZ1	161	P86791
VKLLKERLEKFFHRY	CCZ1B	161	P86790
FDKLAAKYHQLRIKI	ADCY3	351	O60266
FKRLQHLLKEKKRRY	KANSL2	211	Q9H9L4
AFLKEAARKRKFHVI	EIF2B2	176	P49770
LKYVGHIFRKVKRRS	CACNA1H	461	O95180
HKLLRIETAYDFIKR	PIWIL3	286	Q7Z3Z3
LAFAALYYKKDKRRH	NLGN4X	691	Q8N0W4
KYRAAAFKLLLARKS	MLNR	361	O43193
LKQLAEYRKYIHSRK	RHOBTB3	591	O94955
RAAKCRAYAKALHYK	MTOR	1386	P42345
LHALIRDYREKKKIL	MTOR	2246	P42345
FLFRRCFKVKHDALK	TMEM126B	91	Q8IUX1
KYLIRKHRFEEKAQV	MKLN1	636	Q9UL63
FVLKAGYLEKRRKDH	SKAP2	116	O75563
QVRDKFKKFDHRYLR	SLC9A4	516	Q6AI14
FKKFDHRYLRKILIR	SLC9A4	521	Q6AI14
DFKKIKERIRNHKYR	SMARCA4	1506	P51532
LLAKYRKIHLFDIDV	NIT2	106	Q9NQR4
RLIRKDTPHYKKHFK	SCRIB	601	Q14160
ELARLKFEKYFNHKA	UBA6	701	A0AVT1
VKAFYRRAQAHKALK	TOMM34	261	Q15785
FYEKALFRRHVKKAT	ZBTB11	831	O95625
AFDYRKRKHVFKLGL	SPTBN2	2286	O15020
ARKARKYEIPHFRLK	PHTF1	571	Q9UMS5
VKAFYRRALAHKGLK	SPAG1	691	Q07617
HKYRFTLFGIANKKR	TNXB	1221	P22105
IHRYFVDKAAARKVL	TOP1MT	141	Q969P6
FHRYSGKERKRFKLS	S100Z	16	Q8WXG8
KLKEYLKFHVIRDAK	STAB2	1806	Q8WWQ8
YVKALFRRAKAHEKL	TOMM70	186	O94826
ILRKARSYIKHRKFD	PIGN	401	O95427
HKEFKARVKEYARNK	SETD2	1586	Q9BYW2
YRLHRETHAKKKFLE	ZNF445	556	P59923
SKDALLKRARKLHLY	UBN1	421	Q9NPG3
KTFRYRANLKKHLCL	ZNF425	281	Q6IV72
LKYLRLRKAAKATVF	TBRG1	36	Q3YBR2
KKFREAIGKYHRALL	TTC9	71	Q92623
RRYKFLKDKFREAHG	UTF1	116	Q5T230
FKARYRFKKDGKRHI	MYBPC2	391	Q14324
RFGSAKVLKNLYRKH	MYRIP	131	Q8NFW9
IFIEIAYKRHKDARR	GRIN1	831	Q05586