Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	insulin binding	INSR IGF1R PIK3R1	4.03e-06	5	149	3	GO:0043559
GeneOntologyMolecularFunction	L-aspartate:2-oxoglutarate aminotransferase activity	GOT1 GOT2	1.65e-04	3	149	2	GO:0004069
GeneOntologyMolecularFunction	insulin receptor activity	INSR IGF1R	1.65e-04	3	149	2	GO:0005009
GeneOntologyMolecularFunction	insulin receptor substrate binding	INSR IGF1R PIK3R1	1.73e-04	15	149	3	GO:0043560
GeneOntologyMolecularFunction	SUMO ligase activity	RGPD4 RANBP2 RGPD1	4.23e-04	20	149	3	GO:0061665
GeneOntologyMolecularFunction	nuclear receptor binding	ASXL1 KDM4C NR1H3 UBA3 NR4A1 CRY1 PIK3R1	5.18e-04	187	149	7	GO:0016922
GeneOntologyBiologicalProcess	regulation of response to biotic stimulus	ITCH TNIP3 SARM1 VSIG4 LAG3 EMILIN2 NLRP1 NR1H3 TLR9 PARP14 POLR3D TKFC CLPB PIK3R1 NFKBIA RNF26	1.34e-05	643	146	16	GO:0002831
GeneOntologyBiologicalProcess	regulation of innate immune response	ITCH TNIP3 SARM1 VSIG4 LAG3 NLRP1 NR1H3 TLR9 PARP14 POLR3D TKFC CLPB PIK3R1 NFKBIA	1.98e-05	519	146	14	GO:0045088
GeneOntologyBiologicalProcess	positive regulation of response to biotic stimulus	ITCH TNIP3 SARM1 LAG3 EMILIN2 NLRP1 NR1H3 TLR9 POLR3D TKFC CLPB PIK3R1 NFKBIA	2.00e-05	451	146	13	GO:0002833
GeneOntologyBiologicalProcess	positive regulation of glucokinase activity	RGPD4 RANBP2 RGPD1	2.83e-05	9	146	3	GO:0033133
GeneOntologyBiologicalProcess	positive regulation of hexokinase activity	RGPD4 RANBP2 RGPD1	4.02e-05	10	146	3	GO:1903301
GeneOntologyBiologicalProcess	intracellular receptor signaling pathway	ASXL1 ITCH KDM4C NLRP1 NR1H3 TLR9 NR4A1 EZH2 CRY1 TKFC CLPB NFKBIA	4.18e-05	416	146	12	GO:0030522
GeneOntologyBiologicalProcess	positive regulation of innate immune response	ITCH TNIP3 SARM1 LAG3 NLRP1 NR1H3 TLR9 POLR3D TKFC CLPB PIK3R1 NFKBIA	4.59e-05	420	146	12	GO:0045089
GeneOntologyBiologicalProcess	pattern recognition receptor signaling pathway	ITCH TNIP3 SARM1 NLRP1 NR1H3 TLR9 TKFC CLPB PIK3R1 NFKBIA	4.78e-05	294	146	10	GO:0002221
GeneOntologyBiologicalProcess	glutamate catabolic process to aspartate	GOT1 GOT2	4.98e-05	2	146	2	GO:0019550
GeneOntologyBiologicalProcess	positive regulation of defense response	ITCH PLA2G3 TNIP3 SARM1 LAG3 EMILIN2 NLRP1 NR1H3 TLR9 POLR3D TKFC CLPB PIK3R1 NFKBIA	7.80e-05	589	146	14	GO:0031349
GeneOntologyBiologicalProcess	innate immune response-activating signaling pathway	ITCH TNIP3 SARM1 NLRP1 NR1H3 TLR9 TKFC CLPB PIK3R1 NFKBIA	7.84e-05	312	146	10	GO:0002758
GeneOntologyBiologicalProcess	regulation of glucokinase activity	RGPD4 RANBP2 RGPD1	9.43e-05	13	146	3	GO:0033131
GeneOntologyBiologicalProcess	regulation of hexokinase activity	RGPD4 RANBP2 RGPD1	1.19e-04	14	146	3	GO:1903299
GeneOntologyBiologicalProcess	activation of innate immune response	ITCH TNIP3 SARM1 NLRP1 NR1H3 TLR9 TKFC CLPB PIK3R1 NFKBIA	1.34e-04	333	146	10	GO:0002218
GeneOntologyBiologicalProcess	aspartate biosynthetic process	GOT1 GOT2	1.49e-04	3	146	2	GO:0006532
GeneOntologyBiologicalProcess	aspartate catabolic process	GOT1 GOT2	1.49e-04	3	146	2	GO:0006533
GeneOntologyBiologicalProcess	fumarate metabolic process	GOT1 GOT2	1.49e-04	3	146	2	GO:0006106
GeneOntologyBiologicalProcess	positive regulation of immune system process	MPL ITCH ICAM1 PLA2G3 TNIP3 SARM1 VSIG4 LAG3 NLRP1 NR1H3 SIRPB2 TLR9 POLR3D TKFC CLPB PIK3R1 NFKBIA C1S ACTL6B PLCG1 AP3D1	1.79e-04	1242	146	21	GO:0002684
GeneOntologyBiologicalProcess	regulation of immune response	ITCH RIPK3 TNIP3 SARM1 VSIG4 LAG3 NLRP1 NR1H3 TLR9 PARP14 POLR3D TKFC PTPRD CLPB PIK3R1 NFKBIA C1S PLCG1 IGSF1	2.41e-04	1085	146	19	GO:0050776
GeneOntologyBiologicalProcess	positive regulation of response to external stimulus	ITCH PLA2G3 TNIP3 SARM1 LAG3 EMILIN2 NLRP1 NR1H3 TLR9 POLR3D TKFC IGF1R CLPB PIK3R1 NFKBIA	2.41e-04	738	146	15	GO:0032103
GeneOntologyBiologicalProcess	regulation of defense response	ITCH PLA2G3 TNIP3 SARM1 VSIG4 LAG3 EMILIN2 NLRP1 NR1H3 TLR9 PARP14 POLR3D TKFC CLPB PIK3R1 NFKBIA PLCG1 RNF26	2.74e-04	1006	146	18	GO:0031347
GeneOntologyBiologicalProcess	acrosome reaction	PLB1 PKDREJ CCDC87 RIMS1	3.39e-04	47	146	4	GO:0007340
GeneOntologyBiologicalProcess	NLS-bearing protein import into nucleus	RGPD4 RANBP2 RGPD1	3.63e-04	20	146	3	GO:0006607
GeneOntologyBiologicalProcess	dicarboxylic acid catabolic process	ACSF3 GOT1 GOT2	3.63e-04	20	146	3	GO:0043649
GeneOntologyBiologicalProcess	regulation of acrosome reaction	PLB1 PKDREJ CCDC87	3.63e-04	20	146	3	GO:0060046
GeneOntologyBiologicalProcess	carbohydrate biosynthetic process	RGPD4 RANBP2 INSR RGPD1 CRY1 NDST3 UGP2 GOT1	3.85e-04	247	146	8	GO:0016051
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD4 RANBP2 RGPD1	1.90e-05	8	148	3	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD4 RANBP2 RGPD1	4.02e-05	10	148	3	GO:0044614
GeneOntologyCellularComponent	annulate lamellae	RGPD4 RANBP2 RGPD1	1.20e-04	14	148	3	GO:0005642
GeneOntologyCellularComponent	nuclear pore nuclear basket	RGPD4 RANBP2 RGPD1	2.62e-04	18	148	3	GO:0044615
GeneOntologyCellularComponent	insulin receptor complex	INSR IGF1R	2.96e-04	4	148	2	GO:0005899
GeneOntologyCellularComponent	nuclear inclusion body	RGPD4 RANBP2 RGPD1	3.63e-04	20	148	3	GO:0042405
GeneOntologyCellularComponent	SUMO ligase complex	RGPD4 RANBP2 RGPD1	4.21e-04	21	148	3	GO:0106068
GeneOntologyCellularComponent	inclusion body	RGPD4 RANBP2 BAG3 RGPD1 URB2	4.51e-04	90	148	5	GO:0016234
GeneOntologyCellularComponent	transferase complex	RGPD4 RANBP2 ITCH TANK NAA15 EP400 INSR RGPD1 CUL9 EZH2 PHKA2 KLHDC1 POLR3D IGF1R PIK3R1 ACTL6B SGF29	4.80e-04	963	148	17	GO:1990234
Domain	Ran_BP1	RGPD4 RANBP2 RGPD1	1.06e-04	12	150	3	PF00638
Domain	RANBD1	RGPD4 RANBP2 RGPD1	1.06e-04	12	150	3	PS50196
Domain	RanBD	RGPD4 RANBP2 RGPD1	1.37e-04	13	150	3	SM00160
Domain	Ran_bind_dom	RGPD4 RANBP2 RGPD1	1.37e-04	13	150	3	IPR000156
Domain	Ago_hook	TNRC6B TNRC6C	1.91e-04	3	150	2	PF10427
Domain	CLCA_chordata	CLCA4 CLCA1	1.91e-04	3	150	2	IPR004727
Domain	CLCA	CLCA4 CLCA1	1.91e-04	3	150	2	IPR013642
Domain	Asp_trans	GOT1 GOT2	1.91e-04	3	150	2	IPR000796
Domain	NHTrfase_class1_PyrdxlP-BS	GOT1 GOT2	1.91e-04	3	150	2	IPR004838
Domain	CLCA	CLCA4 CLCA1	1.91e-04	3	150	2	PF08434
Domain	TNRC6_PABC-bd	TNRC6B TNRC6C	1.91e-04	3	150	2	IPR032226
Domain	Argonaute_hook_dom	TNRC6B TNRC6C	1.91e-04	3	150	2	IPR019486
Domain	Tyr_kinase_insulin-like_rcpt	INSR IGF1R	1.91e-04	3	150	2	IPR016246
Domain	TNRC6-PABC_bdg	TNRC6B TNRC6C	1.91e-04	3	150	2	PF16608
Domain	fn3	MPL CHL1 INSR MYOM3 FNDC1 IGF1R PTPRD	3.38e-04	162	150	7	PF00041
Domain	WW	ITCH NEDD4L BAG3 TCERG1	5.45e-04	47	150	4	PF00397
Domain	WW	ITCH NEDD4L BAG3 TCERG1	5.91e-04	48	150	4	SM00456
Domain	IGc2	CHL1 UNC5B VSIG4 MYOM3 SIRPB2 PTPRD PXDNL IGSF1	6.34e-04	235	150	8	SM00408
Domain	Ig_sub2	CHL1 UNC5B VSIG4 MYOM3 SIRPB2 PTPRD PXDNL IGSF1	6.34e-04	235	150	8	IPR003598
Domain	SANT	EP400 EZH2 ZSCAN20 ZNF541	6.91e-04	50	150	4	SM00717
Domain	WW_DOMAIN_1	ITCH NEDD4L BAG3 TCERG1	7.45e-04	51	150	4	PS01159
Domain	WW_DOMAIN_2	ITCH NEDD4L BAG3 TCERG1	7.45e-04	51	150	4	PS50020
Domain	FN3	MPL CHL1 INSR MYOM3 FNDC1 IGF1R PTPRD	7.47e-04	185	150	7	SM00060
Domain	WW_dom	ITCH NEDD4L BAG3 TCERG1	8.02e-04	52	150	4	IPR001202
Domain	SANT/Myb	EP400 EZH2 ZSCAN20 ZNF541	8.02e-04	52	150	4	IPR001005
Domain	-	MPL CHL1 UNC5B ICAM1 INSR VSIG4 LAG3 MYOM3 SIRPB2 FNDC1 IGF1R PTPRD PXDNL IGSF1	9.26e-04	663	150	14	2.60.40.10
Domain	AA_TRANSFER_CLASS_1	GOT1 GOT2	9.41e-04	6	150	2	PS00105
Domain	Alpha/beta_knot_MTases	EMG1 TARBP1	9.41e-04	6	150	2	IPR029028
Domain	FN3	MPL CHL1 INSR MYOM3 FNDC1 IGF1R PTPRD	1.14e-03	199	150	7	PS50853
Domain	Recep_L_domain	INSR IGF1R	1.31e-03	7	150	2	PF01030
Domain	Rab_bind	RGPD4 RGPD1	1.31e-03	7	150	2	PF16704
Domain	Furin-like	INSR IGF1R	1.31e-03	7	150	2	PF00757
Domain	Rcpt_L-dom	INSR IGF1R	1.31e-03	7	150	2	IPR000494
Domain	GCC2_Rab_bind	RGPD4 RGPD1	1.31e-03	7	150	2	IPR032023
Domain	Furin-like_Cys-rich_dom	INSR IGF1R	1.31e-03	7	150	2	IPR006211
Domain	-	INSR IGF1R	1.31e-03	7	150	2	3.80.20.20
Domain	FN3_dom	MPL CHL1 INSR MYOM3 FNDC1 IGF1R PTPRD	1.52e-03	209	150	7	IPR003961
Domain	ARM-like	RELCH SARM1 CUL9 BTAF1 SCYL2 MROH6 TARBP1 AP3D1	1.55e-03	270	150	8	IPR011989
Domain	Ig-like_fold	MPL CHL1 UNC5B ICAM1 INSR VSIG4 LAG3 MYOM3 SIRPB2 FNDC1 IGF1R PTPRD PXDNL IGSF1	1.68e-03	706	150	14	IPR013783
Pubmed	Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.	INSR IGF1R PIK3R1 PLCG1	4.58e-08	9	154	4	11094073
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ABCF1 ITCH GALNT2 KDM4C PLA2G3 MYRIP CUL9 UBA3 DZIP1 SCYL2 CEP350 UBE2O PTPRD CLPB TCERG1 NECAB1 PIK3R1 DENND6B C1S PLCG1 QARS1 TARBP1	6.04e-08	1285	154	22	35914814
Pubmed	PLC-gamma1 enzyme activity is required for insulin-induced DNA synthesis.	INSR PIK3R1 PLCG1	8.51e-08	3	154	3	11796522
Pubmed	Interaction of the molecular weight 85K regulatory subunit of the phosphatidylinositol 3-kinase with the insulin receptor and the insulin-like growth factor-1 (IGF- I) receptor: comparative study using the yeast two-hybrid system.	INSR IGF1R PIK3R1	8.51e-08	3	154	3	8603569
Pubmed	Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin.	INSR PIK3R1 PLCG1	8.46e-07	5	154	3	9593725
Pubmed	A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.	ITCH NEDD4L UBA3 UBE2O UBE2T UGP2	2.75e-06	88	154	6	27182664
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	9037092
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	11353387
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	38838144
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	7559465
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	17372272
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	38657106
Pubmed	RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death.	INSR IGF1R PIK3R1	2.94e-06	7	154	3	11964397
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	21205196
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	18949001
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	25187515
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	8603673
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	26632511
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	24403063
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	23818861
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	23536549
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	22821000
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RGPD4 RANBP2 RGPD1	2.94e-06	7	154	3	20682751
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RGPD4 RANBP2 RGPD1	4.69e-06	8	154	3	21670213
Pubmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.	RGPD4 RANBP2 RGPD1	4.69e-06	8	154	3	27412403
Pubmed	Mice lacking Ran binding protein 1 are viable and show male infertility.	RGPD4 RANBP2 RGPD1	4.69e-06	8	154	3	21310149
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RGPD4 RANBP2 RGPD1	4.69e-06	8	154	3	22262462
Pubmed	Comparative analysis of the signaling capabilities of the insulin receptor-related receptor.	INSR IGF1R PIK3R1	4.69e-06	8	154	3	15629149
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RGPD4 RANBP2 RGPD1	4.69e-06	8	154	3	28745977
Pubmed	Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.	IRF2BP2 ITCH TANK RIPK3 NEDD4L SARM1 BAG3 TLR9 CCDC191	5.21e-06	283	154	9	21903422
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RGPD4 RANBP2 RGPD1	7.01e-06	9	154	3	18394993
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	RGPD4 RANBP2 RGPD1	7.01e-06	9	154	3	28100513
Pubmed	Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.	RGPD4 RANBP2 RGPD1	7.01e-06	9	154	3	17887960
Pubmed	The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.	RGPD4 RANBP2 RGPD1	7.01e-06	9	154	3	11553612
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RGPD4 RANBP2 RGPD1	7.01e-06	9	154	3	10601307
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RGPD4 RANBP2 RGPD1	7.01e-06	9	154	3	9733766
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RGPD4 RANBP2 RGPD1	7.01e-06	9	154	3	28877029
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ABCF1 NAA15 GALNT2 MINK1 ZNF629 BTAF1 EZH2 ANKZF1 PHKA2 TCERG1 CARD6 EMG1 AP3D1	7.10e-06	650	154	13	38777146
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	RGPD4 RANBP2 ABCF1 RGPD1 GPRIN1 SLC4A10 RIMS1 AP3D1	9.52e-06	231	154	8	16452087
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RGPD4 RANBP2 RGPD1	9.99e-06	10	154	3	27160050
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RGPD4 RANBP2 RGPD1	9.99e-06	10	154	3	16332688
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	RGPD4 RANBP2 RGPD1	9.99e-06	10	154	3	8857542
Pubmed	The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.	INSR IGF1R PIK3R1	9.99e-06	10	154	3	9062339
Pubmed	Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.	RGPD4 RANBP2 RGPD1	9.99e-06	10	154	3	21859863
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RGPD4 RANBP2 RGPD1	1.37e-05	11	154	3	17069463
Pubmed	An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.	RGPD4 RANBP2 RGPD1	1.37e-05	11	154	3	35771867
Pubmed	T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.	RGPD4 RANBP2 RGPD1	1.37e-05	11	154	3	34110283
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	ANKS6 ABCF1 NEDD4L TNRC6C NR4A1 ANKZF1 CRY1 SCYL2 CEP350 STK4 POLR3D MROH6 CLPB NFKBIA KNDC1 AP3D1	1.61e-05	1038	154	16	26673895
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	IRF2BP2 RANBP2 ABCF1 NAA15 EP400 BAG3 TNRC6B BTAF1 GPRIN1 SCYL2 STK4 UBE2O TCERG1 PLCG1 AP3D1	1.87e-05	934	154	15	33916271
Pubmed	Nucleotide sequence and tissue distribution of the human mitochondrial aspartate aminotransferase mRNA.	GOT1 GOT2	1.95e-05	2	154	2	3207426
Pubmed	Heterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibody.	INSR IGF1R	1.95e-05	2	154	2	22438913
Pubmed	Insulin and IGF-1 have both overlapping and distinct effects on CD4+ T cell mitochondria, metabolism, and function.	INSR IGF1R	1.95e-05	2	154	2	38383709
Pubmed	EZH2 mutations in chronic myelomonocytic leukemia cluster with ASXL1 mutations and their co-occurrence is prognostically detrimental.	ASXL1 EZH2	1.95e-05	2	154	2	29358618
Pubmed	Structural and genetic relationships between cytosolic and mitochondrial isoenzymes.	GOT1 GOT2	1.95e-05	2	154	2	6397370
Pubmed	Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth, cell migration and angiogenesis.	INSR IGF1R	1.95e-05	2	154	2	24809298
Pubmed	A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis.	INSR IGF1R	1.95e-05	2	154	2	21139139
Pubmed	The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.	INSR IGF1R	1.95e-05	2	154	2	25758790
Pubmed	A fluorescent indicator for tyrosine phosphorylation-based insulin signaling pathways.	INSR PIK3R1	1.95e-05	2	154	2	10500481
Pubmed	Ligand-binding properties of the two isoforms of the human insulin receptor.	INSR PIK3R1	1.95e-05	2	154	2	8440175
Pubmed	The orphan nuclear receptor Nur77 suppresses endothelial cell activation through induction of IkappaBalpha expression.	NR4A1 NFKBIA	1.95e-05	2	154	2	19213954
Pubmed	Compounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cells.	INSR IGF1R	1.95e-05	2	154	2	27384680
Pubmed	Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart.	INSR IGF1R	1.95e-05	2	154	2	35786404
Pubmed	Insulin-Mediated Signaling Facilitates Resistance to PDGFR Inhibition in Proneural hPDGFB-Driven Gliomas.	INSR IGF1R	1.95e-05	2	154	2	28138037
Pubmed	Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation.	INSR IGF1R	1.95e-05	2	154	2	30070361
Pubmed	Cockroach allergen Per a 7 down-regulates expression of Toll-like receptor 9 and IL-12 release from P815 cells through PI3K and MAPK signaling pathways.	TLR9 PIK3R1	1.95e-05	2	154	2	22508063
Pubmed	Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes.	INSR IGF1R	1.95e-05	2	154	2	31562314
Pubmed	Insulin-like growth factor I receptors are more abundant than insulin receptors in human micro- and macrovascular endothelial cells.	INSR IGF1R	1.95e-05	2	154	2	14722023
Pubmed	Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance.	INSR IGF1R	1.95e-05	2	154	2	17416680
Pubmed	Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling.	INSR IGF1R	1.95e-05	2	154	2	22692545
Pubmed	High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy.	INSR IGF1R	1.95e-05	2	154	2	21177763
Pubmed	Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes.	INSR IGF1R	1.95e-05	2	154	2	18693051
Pubmed	The activation of liver X receptors inhibits toll-like receptor-9-induced foam cell formation.	NR1H3 TLR9	1.95e-05	2	154	2	20049870
Pubmed	Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function.	INSR IGF1R	1.95e-05	2	154	2	19817984
Pubmed	Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.	INSR IGF1R	1.95e-05	2	154	2	19744489
Pubmed	Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.	INSR IGF1R	1.95e-05	2	154	2	28065828
Pubmed	Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior.	INSR IGF1R	1.95e-05	2	154	2	30765523
Pubmed	Functional collaboration of insulin-like growth factor-1 receptor (IGF-1R), but not insulin receptor (IR), with acute GH signaling in mouse calvarial cells.	INSR IGF1R	1.95e-05	2	154	2	24302626
Pubmed	Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cells.	INSR IGF1R	1.95e-05	2	154	2	22879999
Pubmed	Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling.	INSR IGF1R	1.95e-05	2	154	2	36548088
Pubmed	Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function.	INSR IGF1R	1.95e-05	2	154	2	17189427
Pubmed	[Effects of insulin on expression of insulin receptor and insulin-like growth factor-1 receptor and proliferation in Reh cells].	INSR IGF1R	1.95e-05	2	154	2	22541124
Pubmed	A functional assessment of insulin/insulin-like growth factor-I hybrid receptors.	INSR IGF1R	1.95e-05	2	154	2	7895674
Pubmed	Insulin receptor and IGF1R are not required for oocyte growth, differentiation, and maturation in mice.	INSR IGF1R	1.95e-05	2	154	2	19851056
Pubmed	New automated measurement of mitochondrial aspartate aminotransferase with use of protease 401.	GOT1 GOT2	1.95e-05	2	154	2	2182221
Pubmed	Combined and individual tumor-specific expression of insulin-like growth factor-I receptor, insulin receptor and phospho-insulin-like growth factor-I receptor/insulin receptor in primary breast cancer: Implications for prognosis in different treatment groups.	INSR IGF1R	1.95e-05	2	154	2	28030849
Pubmed	Cloning and sequence analysis of mRNA for mouse aspartate aminotransferase isoenzymes.	GOT1 GOT2	1.95e-05	2	154	2	3782150
Pubmed	Insulin-like growth factor type 1 receptor and insulin receptor isoform expression and signaling in mammary epithelial cells.	INSR IGF1R	1.95e-05	2	154	2	19406949
Pubmed	Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis.	INSR IGF1R	1.95e-05	2	154	2	27905925
Pubmed	The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.	CLCA4 CLCA1	1.95e-05	2	154	2	15490240
Pubmed	Placental glycogen stores are increased in mice with H19 null mutations but not in those with insulin or IGF type 1 receptor mutations.	INSR IGF1R	1.95e-05	2	154	2	19524295
Pubmed	Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation.	INSR IGF1R	1.95e-05	2	154	2	18650937
Pubmed	A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding.	INSR IGF1R	1.95e-05	2	154	2	30213860
Pubmed	Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms.	ASXL1 EZH2	1.95e-05	2	154	2	21455215
Pubmed	Epithelial-mesenchymal transition predicts sensitivity to the dual IGF-1R/IR inhibitor OSI-906 in hepatocellular carcinoma cell lines.	INSR IGF1R	1.95e-05	2	154	2	22161861
Pubmed	Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity.	INSR IGF1R	1.95e-05	2	154	2	29040448
Pubmed	IGF-I: a mitogen also involved in differentiation processes in mammalian cells.	IGF1R PIK3R1	1.95e-05	2	154	2	8697095
Pubmed	A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II.	INSR IGF1R	1.95e-05	2	154	2	19139090
Pubmed	Apolipoprotein C3 and circulating mediators of preadipocyte proliferation in states of lipodystrophy.	INSR IGF1R	1.95e-05	2	154	2	35964946
Interaction	TMEM92 interactions	ITCH NEDD4L RTP2 BAG3	6.17e-06	17	148	4	int:TMEM92
GeneFamily	Fibronectin type III domain containing	MPL CHL1 INSR MYOM3 FNDC1 IGF1R PTPRD	2.99e-05	160	100	7	555
GeneFamily	Chloride channel accessory	CLCA4 CLCA1	1.80e-04	4	100	2	867
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	EP400 EZH2 ZSCAN20 ZNF541	2.10e-04	53	100	4	532
GeneFamily	Ataxins\|Trinucleotide repeat containing	EP400 TNRC6B TNRC6C	3.46e-04	25	100	3	775
GeneFamily	Immunoglobulin like domain containing	CHL1 ICAM1 VSIG4 LAG3 MYOM3 IGSF1	7.11e-04	193	100	6	594
GeneFamily	SPOUT methyltranferase domain containing	EMG1 TARBP1	8.30e-04	8	100	2	1294
GeneFamily	Tudor domain containing	KDM4C TDRD6 SGF29	1.11e-03	37	100	3	780
GeneFamily	Phospholipases	PLB1 PLA2G3 PLCG1	1.61e-03	42	100	3	467
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	CHL1 UNC5B MYOM3 PTPRD PXDNL	2.01e-03	161	100	5	593
CoexpressionAtlas	DevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_k-means-cluster#1_top-relative-expression-ranked_1000	RELCH INSR CEP350 THBS2 CLCA1 C1S ATP13A3 RIMS1	8.19e-06	149	144	8	gudmap_developingLowerUrinaryTract_P1_bladder_J_1000_k1
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ASXL1 BAG3 PLEKHA4 BTAF1 NR4A1 CRY1 NFKBIA ATP13A3	3.79e-07	193	154	8	dbf0fe496254320c894568c31e5f9ce63707d1b5
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ASXL1 ITCH ZNF629 STK4 FNDC1 THBS2 PLCG1	4.21e-06	188	154	7	14bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	ACER2 UNC5B MINK1 BTAF1 CEP350 SPTBN5	4.25e-06	122	154	6	1ed865f0ecfe304fb86313ff51c04e9052357270
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ASXL1 ICAM1 BAG3 NR4A1 CRY1 NFKBIA ATP13A3	4.83e-06	192	154	7	6bba80887d6f64cf913a5c22f62baaddda417ce0
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ICAM1 BAG3 PLEKHA4 NR4A1 CRY1 SCYL2 ATP13A3	4.83e-06	192	154	7	3f925a80b5e2b0577d573e88598a2984a5f6a789
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLB1 AFF3 VSIG4 NLRP1 SIRPB2 ZNF710 SLC8A1	5.00e-06	193	154	7	3e3d7cb3e7242ec9c9677e07e303835649852b52
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEDD4L SLC8A1 PTPRD NECAB1 PIK3R1 SLC4A10 RIMS1	5.35e-06	195	154	7	2e1df01bf6e4e98e6cd9fb50926e34c5077b8666
ToppCell	control-immature_Neutrophil\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ANKS6 ZNF629 SIRPB2 GPRIN1 IGF1R CLPB SLC4A10	5.53e-06	196	154	7	e34fd3e7a5b1c22a81fd3208e6d58bdb846d51c4
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 VSIG4 EMILIN2 NLRP1 SIRPB2 ZNF710 SLC8A1	5.53e-06	196	154	7	291c59b609985167c98a40d4e2caeea2fad74941
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 VSIG4 EMILIN2 NLRP1 SIRPB2 ZNF710 SLC8A1	5.72e-06	197	154	7	826cc6baafab13e7ef5cfcf28cd79d0fbf3af38d
ToppCell	LPS-antiTNF-Unknown\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FOXM1 UBE2T ZSCAN22 PIMREG TIGD5 CCDC191	5.86e-06	129	154	6	739b263296c28554967362060b154f7a95e1341d
ToppCell	Sepsis-Bac-SEP-Lymphocyte-T/NK-MAIT\|Bac-SEP / Disease, condition lineage and cell class	ACP6 LAG3 C1orf167 SPTBN5 PIK3R1 NFKBIA SLC4A10	5.91e-06	198	154	7	aea3654b16785aa9857ed646bd0d0dc9724df364
ToppCell	LPS-antiTNF-Unknown-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FOXM1 UBE2T ZSCAN22 PIMREG TIGD5 CCDC191	6.13e-06	130	154	6	615c233c7c2600c1c2bc5cf5b1c501fc474564ef
ToppCell	Bronchial_Biopsy-Immune-T_and_NK\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	SARM1 MYRIP KLHDC1 SLC4A10 SHE PLCG1	2.64e-05	168	154	6	435b2f238fbb3f50427e8cdecf2220615015153c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	VSIG4 EMILIN2 SIRPB2 ZNF710 SLC8A1 ZSCAN22	2.73e-05	169	154	6	b2fdf9f842dc7c181bc951a8a6932c916ed835ef
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	VSIG4 EMILIN2 SIRPB2 ZNF710 SLC8A1 ZSCAN22	2.73e-05	169	154	6	2322f03a115c662f808ebfc892192b7d38d48181
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 KDM4C TMEM94 ADRA2A NECAB1 PIMREG	3.21e-05	174	154	6	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTHL1 DZIP1 PTPRD RNASE10 C1S TTLL1	3.76e-05	179	154	6	b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 PLEKHH3 CRY1 NDST3 FNDC1 POLR3D	4.13e-05	182	154	6	e3248d108b51c49ca2c978636e13017e23b53860
ToppCell	droplet-Spleen-nan-24m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 SARM1 EZH2 PLEKHH3 UBE2T PIMREG	4.39e-05	184	154	6	b998803180322a5ea2b567928dea531c26816c3c
ToppCell	LPS_only\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TANK ICAM1 EZH2 CRY1 NFKBIA ATP13A3	4.52e-05	185	154	6	a72ccb147ca505880e2da8f6a70b9d570464a691
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ICAM1 BAG3 VSIG4 NR4A1 NFKBIA RNASET2	4.80e-05	187	154	6	98026c1aaf8de280470ad75536121357934fc78d
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	RANBP2 TNRC6B BTAF1 PARP14 CRY1 ATP13A3	4.94e-05	188	154	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	RA-14._Fibroblast_III\|RA / Chamber and Cluster_Paper	RANBP2 GALNT2 ICAM1 NR4A1 THBS2 ATP13A3	5.09e-05	189	154	6	46e9a58aacd79db5a02898a8c7244e1884adcfd1
ToppCell	RA-14._Fibroblast_III\|World / Chamber and Cluster_Paper	RANBP2 GALNT2 ICAM1 NR4A1 THBS2 ATP13A3	5.09e-05	189	154	6	b6e12d24d2b0735730bdc625f8318c1c9c2a9b3b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLB1 AFF3 VSIG4 EMILIN2 SIRPB2 SLC8A1	5.24e-05	190	154	6	788ff9d8888d2dd25b7e1d7e0e5d57751ce86f19
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RANBP2 ICAM1 BAG3 NR4A1 NFKBIA RNASET2	5.24e-05	190	154	6	4d401b73c0e7eb38e95d0851a128bf12bb0d3a9f
ToppCell	NS-critical-d_16-33-Myeloid-Non-resident_Macrophage\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TNIP3 VSIG4 EMILIN2 NR1H3 SLC8A1 NFKBIA	5.24e-05	190	154	6	4fe9654a9b449ef49ca10b973ac4378dab34cb53
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLB1 AFF3 VSIG4 EMILIN2 SIRPB2 SLC8A1	5.40e-05	191	154	6	baa70781633a3fe5bf987f9d8dff3884f5167e7f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 NR4A1 KIAA1210 CBLN4 PIK3R1 VSIG10L2	5.40e-05	191	154	6	2c51850f5c559d665b8a27a12b75af9ed58dffe1
ToppCell	368C-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CHL1 IRF2BP2 UNC5B NR4A1 ATP13A3 ZNF541	5.55e-05	192	154	6	aedddccacf60e884af044cefba6c64ca10ac97d2
ToppCell	368C-Endothelial_cells-Endothelial-B_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CHL1 IRF2BP2 UNC5B NR4A1 ATP13A3 ZNF541	5.55e-05	192	154	6	389d5e6d0689371bfe1d0b06e92e0e6e5573567b
ToppCell	P07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOXM1 EZH2 LIG1 UBE2T PIMREG RNF26	5.55e-05	192	154	6	5ef79faddb433c09ff36660d8bf7a3af5a67bf1d
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNIP3 BAG3 VSIG4 EMILIN2 NR1H3 ZSCAN20	5.72e-05	193	154	6	f492ed02a46f3a45dc6005f9f18ab12a84bfa2a3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 NR4A1 KIAA1210 CBLN4 PIK3R1 VSIG10L2	5.72e-05	193	154	6	09a9ab029f01234459a88e3e994fe90ef4cbb8c6
ToppCell	10x5'-GI_small-bowel\|World / Manually curated celltypes from each tissue	TNIP3 BAG3 LAG3 NR4A1 CRY1 PLCG1	5.72e-05	193	154	6	cd89dfe53a114078f06343049685883c8e26508f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GNG13 PLK5 GPRIN1 ACTL6B RIMS1 FRMPD3	5.72e-05	193	154	6	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FOXM1 ABCF1 EZH2 UBE2T PIMREG RIMS1	5.88e-05	194	154	6	7a66bd7d4fc9c6db861cedd2487f241e406869d1
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEDD4L TNIP3 INSR LAG3 ADRA2A RIMS1	5.88e-05	194	154	6	dc531cf9089f2c956621d70d49a2b8219b4b45c1
ToppCell	ILEUM-non-inflamed-(1)_T_cell-(1)_Cytotoxic_CD8_Trm\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ICAM1 LAG3 NR4A1 PIK3R1 NFKBIA SLC4A10	5.88e-05	194	154	6	094e8dfe640c7cca410b85f93063ea0bd7e861cf
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FOXM1 NDST3 KIAA1210 LIG1 UBE2T IGSF1	5.88e-05	194	154	6	590a9d4f054e6a3685daf752c9354650fcc7d18a
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 EZH2 LIG1 UBE2T PIMREG RNF26	6.05e-05	195	154	6	7ae732f100e9a3c6062be5b877efa1ec9d5b3958
ToppCell	10x5'-GI_small-bowel-Myeloid_Mac-Intestinal_macrophages\|GI_small-bowel / Manually curated celltypes from each tissue	UNC5B VSIG4 EMILIN2 NR1H3 SLC8A1 SHE	6.23e-05	196	154	6	075e5746fa5cb121115a1d51b823c0fbf8d54305
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLB1 AFF3 VSIG4 EMILIN2 SIRPB2 SLC8A1	6.23e-05	196	154	6	4370473693d2dd4a8c451a4c477eb79baa33ae12
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo-stroma-osteoblast_precursor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	UNC5B FNDC1 THBS2 PTPRD PXDNL RIMS1	6.23e-05	196	154	6	57df2a57b35be9851ac0b1e5731baa53052511f0
ToppCell	COVID-19-lung-Macrophage_metabolically_active\|COVID-19 / Disease (COVID-19 only), tissue and cell type	VSIG4 EMILIN2 NR1H3 SIRPB2 PARP14 SLC8A1	6.23e-05	196	154	6	1b7928f4eee94d4bb6ea410bab68a471dba12979
ToppCell	Healthy-T/NK_proliferative\|Healthy / disease group, cell group and cell class	FOXM1 MYRIP EZH2 LIG1 UBE2T PIMREG	6.23e-05	196	154	6	91e44aabb2e85dcc77ddae6f7e000118d45d1de6
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 EZH2 LIG1 UBE2T PIMREG RNF26	6.23e-05	196	154	6	5ddd314d3def3776dc7da83778d41c6436ca51ac
ToppCell	BAL-Control-cDC_7\|Control / Compartment, Disease Groups and Clusters	PLB1 LAG3 NR4A1 TKFC EMG1	6.36e-05	121	154	5	b49b044a687a31883dfccecf10a183b5ba567f7a
ToppCell	Control-Myeloid-TRAM3\|Control / Disease group,lineage and cell class （2021.01.30）	ICAM1 TNIP3 PLEKHA4 EMILIN2 PARP14 NFKBIA	6.40e-05	197	154	6	733ff40039d67e561c2ded7c9bd0b4353101741e
ToppCell	Healthy-T/NK_proliferative\|World / disease group, cell group and cell class	FOXM1 MYRIP EZH2 LIG1 UBE2T PIMREG	6.40e-05	197	154	6	e90be1e7e02f736b6aab14010a912b592d6f1e80
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 EMILIN2 NLRP1 ZNF710 STK4 SLC8A1	6.40e-05	197	154	6	c9b1f2ee7eb31a66af331c5aae29e1bbb5186f5a
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-Monocytes\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ICAM1 TNIP3 EMILIN2 SLC8A1 NFKBIA ATP13A3	6.40e-05	197	154	6	d9d58c2fe40d9b5b9031fb7a71525a535927effe
ToppCell	BAL-Control-Myeloid-TRAM-TRAM3\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ICAM1 TNIP3 PLEKHA4 EMILIN2 PARP14 NFKBIA	6.40e-05	197	154	6	4416efdbd9c4ac3356a5dff2d535c2d7383376a9
ToppCell	BAL-Control-Myeloid-TRAM-TRAM3-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ICAM1 TNIP3 PLEKHA4 EMILIN2 PARP14 NFKBIA	6.40e-05	197	154	6	0f1c4a328968b32874e6ebb0803e665adcbbc450
ToppCell	BAL-Control-Myeloid-TRAM-TRAM3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ICAM1 TNIP3 PLEKHA4 EMILIN2 PARP14 NFKBIA	6.40e-05	197	154	6	aafe0cd697b0b7f0756596148e0906443fdf8ef7
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 EZH2 LIG1 UBE2T PIMREG RNF26	6.40e-05	197	154	6	9b2c67de46bd59bf56c81a0d10b84cf4a041c120
ToppCell	BAL-Control-Myeloid-TRAM-TRAM3-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ICAM1 TNIP3 PLEKHA4 EMILIN2 PARP14 NFKBIA	6.40e-05	197	154	6	e131634bc67e0bd31a938a8e8df8dc752e1d0f47
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 EZH2 LIG1 UBE2T PIMREG RNF26	6.40e-05	197	154	6	f84f0ddf51208764ab56408d97035bbff562e59d
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 EZH2 LIG1 UBE2T PIMREG RNF26	6.40e-05	197	154	6	a0d463825b62de49466f9fa563405dda4387cfff
ToppCell	mLN-T_cell-Th17\|mLN / Region, Cell class and subclass	IRF2BP2 TANK CRY1 NFKBIA RNASE10 SLC4A10	6.59e-05	198	154	6	04905f62941b193864704a10ad692faf777fa51d
ToppCell	mLN-(1)_T_cell-(13)_Th17\|mLN / shred on region, Cell_type, and subtype	IRF2BP2 TANK CRY1 NFKBIA RNASE10 SLC4A10	6.59e-05	198	154	6	c575e9aeee4e034e8c4d171fe754403652343731
ToppCell	mLN-T_cell-Th17\|T_cell / Region, Cell class and subclass	IRF2BP2 TANK ICAM1 NFKBIA RNASE10 SLC4A10	6.59e-05	198	154	6	efdc9515dd9fb20ef9c8ddc106d88cbdde7d6ea2
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FOXM1 TNIP3 VSIG4 EZH2 UBE2T PIMREG	6.59e-05	198	154	6	428182c71f009906c581e02257e545ea5fb99650
ToppCell	Healthy_Control-Myeloid-Macrophages-FCN1+SPP1+\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	TANK ICAM1 TNIP3 SLC8A1 NFKBIA ATP13A3	6.59e-05	198	154	6	aa90326b82e21de37af5642df6a70a8b21af7f04
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 VSIG4 EMILIN2 NLRP1 SIRPB2 ZNF710	6.77e-05	199	154	6	04adf46975aa4194ea40c7480f8a517def5d929c
ToppCell	severe_influenza-T/NK_proliferative\|severe_influenza / disease group, cell group and cell class (v2)	FOXM1 LAG3 EZH2 LIG1 UBE2T PIMREG	6.77e-05	199	154	6	638b1491c47f2884daf1c1d38a779ad8e0f59c52
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	NAA15 INSR TNRC6B CEP350 SCAF11 AP3D1	6.77e-05	199	154	6	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FOXM1 LAG3 EZH2 LIG1 UBE2T PIMREG	6.77e-05	199	154	6	101f78fe6dd1bf9e2e4dd5ad8a970312b3540927
ToppCell	tumor_Lung-Endothelial_cells-Tip-like_ECs\|Endothelial_cells / Location, Cell class and cell subclass	NEDD4L AFF3 PARP14 STK4 RNASET2 DISP1	6.77e-05	199	154	6	80c8641cfd84436eadf2234f1313749e2f73331f
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FOXM1 LAG3 EZH2 LIG1 UBE2T PIMREG	6.77e-05	199	154	6	e0fcec796afe75e42467ca86355b9fc5aa9ae0a1
ToppCell	tumor_Lung-Fibroblasts-COL14A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	BAG3 NR4A1 THBS2 CBLN4 NFKBIA C1S	6.77e-05	199	154	6	0d1f2b0d10c1f8ee10c448659b2a22ea0a6a6f0d
ToppCell	Influenza_Severe-T/NK_proliferative\|Influenza_Severe / Disease group and Cell class	FOXM1 LAG3 EZH2 LIG1 UBE2T PIMREG	6.77e-05	199	154	6	2508c55f9ffe17b694c70f1283f41ad4a8e83c00
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ICAM1 BAG3 VSIG4 NR4A1 PARP14 RNASET2	6.77e-05	199	154	6	e7faf7d0cb43cf93149c446e5f718f84fa85477c
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	PLEKHA4 DZIP1 NDST3 FNDC1 PIK3R1 RIMS1	6.96e-05	200	154	6	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BTAF1 PARP14 CEP350 PIK3R1 NFKBIA SCAF11	6.96e-05	200	154	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Artery\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ACER2 CLCA4 SLC8A1 NECAB1 SHE ATP13A3	6.96e-05	200	154	6	ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer\|World / Primary Cells by Cluster	CHL1 AFF3 SLC8A1 PTPRD NECAB1 PIK3R1	6.96e-05	200	154	6	db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21\|World / Primary Cells by Cluster	CHL1 AFF3 SLC8A1 PTPRD NECAB1 PIK3R1	6.96e-05	200	154	6	30a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic-monocyte\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	INSR BAG3 SIRPB2 NR4A1 SLC8A1	7.42e-05	125	154	5	a72891c3fb9cdefa9254f8e2e3c4ffa6fc3a5ffc
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-C1ql2-Excitatory_Neuron.Slc17a7.C1ql2-Cck_(Dentate_Principal_cells)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PTX4 PLB1 RTP2 PLK5 IGSF1	8.61e-05	129	154	5	08ecebb7f09d105dfdfd2191fc310910d3baec0f
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|356C / Donor, Lineage, Cell class and subclass (all cells)	LAG3 NUTM2E STK4 PIK3R1 SLC4A10	1.40e-04	143	154	5	e8fc6540a48086f58bc3f42dabe392ef46715b9e
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HDHD3 PLB1 EMILIN2 NLRP1 TARBP1	1.54e-04	146	154	5	b76110b159acd27a2c8d6a9f98336608ace1ec12
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Crym_(Crym)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ERV3-1 MYOM3 KIAA1210 RNASE10	1.88e-04	82	154	4	bc4e309c0128d126c47895e88d2250324c6ff81a
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Crym_(Crym)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ERV3-1 MYOM3 KIAA1210 RNASE10	1.88e-04	82	154	4	9cd1b8a580566904a1ca0d4b5c48b2bf12a8898b
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Crym_(Crym)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ERV3-1 MYOM3 KIAA1210 RNASE10	1.88e-04	82	154	4	0fb857a83f61d8c26be1b151903f4e6dc69397f9
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LAG3 NBAS KLHDC1 ZSCAN20 PLCG1	1.97e-04	154	154	5	ec920cae12ea1d14b6c973f6e903f895f80e3c50
ToppCell	Healthy_Control-Myeloid-Macrophages-FCN1_high\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	ICAM1 TNIP3 PLEKHA4 NR4A1 NFKBIA	2.03e-04	155	154	5	cd2ccb4632713b4def3a1064599b78207e2e44c0
ToppCell	10x5'-Liver-Myeloid_Mac-Intestinal_macrophages\|Liver / Manually curated celltypes from each tissue	UNC5B VSIG4 NR1H3 NDST3 KNDC1	2.10e-04	156	154	5	9a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	ICAM1 BAG3 NR4A1 ANKZF1 ZNF398	2.22e-04	158	154	5	de65af8d3b8514b17978155f31975e2347b75251
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-FB-1\|E18.5-samps / Age Group, Lineage, Cell class and subclass	NTHL1 POLR3D PTPRD DENND6B DISP1	2.29e-04	159	154	5	b4bc888e978b1b577721b891b0af6ba9a1607044
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_5\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPAG8 RTN2 KLHDC1 ATAD3C UBE2T	2.29e-04	159	154	5	08a1cd71eac4322fb313324f74fe8e37998f2d7d
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_5\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SPAG8 RTN2 KLHDC1 ATAD3C UBE2T	2.29e-04	159	154	5	9bdfa7f5aa7753fe25b787bd43d694b6093d77eb
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACER2 MYRIP SIRPB2 SHE TDRD6	2.36e-04	160	154	5	33050dc646762dc7e9dcc4a12c618e1ba1ce5a4d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	TANK GALNT2 AFF3 PARP14 CCDC191	2.57e-04	163	154	5	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	droplet-Lung-nan-18m-Myeloid-intermediate_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITCH EMILIN2 NR4A1 ZNF710 SLC8A1	2.72e-04	165	154	5	e32697321cef424c2ad4e11ee9da3e510d5ce505
ToppCell	droplet-Lung-nan-18m-Myeloid-Intermediate_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITCH EMILIN2 NR4A1 ZNF710 SLC8A1	2.72e-04	165	154	5	0fbdd043e11aa8dbff4cd3a4da1b2feb49878a09
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXM1 THBS2 TKFC NECAB1 C1S	2.79e-04	166	154	5	49103b75c3e08656c5774f56fd00d7bd53eefcfb
ToppCell	Dividing_Macrophages-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	ACER2 FOXM1 EZH2 UBE2T PIMREG	2.79e-04	166	154	5	ea95b94ccc2ac67df741b30c27f4ae698925875f
ToppCell	CTRL-Myeloid-Monocyte\|CTRL / Disease state, Lineage and Cell class	ICAM1 TNIP3 ADRA2A NFKBIA ATP13A3	2.95e-04	168	154	5	13dca90c7b811e4d5e8fa44f5e892e29be9787a6
Drug	qBBr	INSR NLRP1 GOT1 GOT2	4.14e-06	17	151	4	CID000126515
Drug	2,4,5,2',5'-pentachlorobiphenyl	FOXM1 HDHD3 NEDD4L EP400 GNG13 RTP2 TNIP3 URB2 PARP14 EZH2 FNDC1 SLC8A1 CBLN4 UBE2T NECAB1 NFKBIA SLC4A10 KNDC1 SHE PIMREG RIMS1 PLCG1 FRMPD3 TDRD6	2.72e-05	1441	151	24	ctd:C009828
Drug	hydrazinosuccinate	GOT1 GOT2	4.37e-05	2	151	2	CID000124897
Drug	Insulin Glargine	INSR IGF1R	4.37e-05	2	151	2	ctd:D000069036
Drug	Insulin Lispro	INSR IGF1R	4.37e-05	2	151	2	DB00046
Drug	Insulin Glargine	INSR IGF1R	4.37e-05	2	151	2	DB00047
Drug	nitrosomethoxymethylamine	GOT1 GOT2	4.37e-05	2	151	2	CID000027827
Drug	perfluorosuccinate	GOT1 GOT2	4.37e-05	2	151	2	CID000067833
Drug	pyridoxal 5'-sulfate	GOT1 GOT2	4.37e-05	2	151	2	CID000162410
Drug	beta-Ethylideneaspartate	GOT1 GOT2	4.37e-05	2	151	2	CID006444096
Drug	BAPM	GOT1 GOT2	4.37e-05	2	151	2	CID000191773
Drug	cystinedisulfoxide	GOT1 GOT2	4.37e-05	2	151	2	CID000121714
Drug	threo-alpha-cycloglutamic acid	GOT1 GOT2	4.37e-05	2	151	2	CID000193353
Drug	6-fluoropyridoxamine 5'-phosphate	GOT1 GOT2	4.37e-05	2	151	2	CID006451848
Drug	Ta 4	GOT1 GOT2	4.37e-05	2	151	2	CID000203778
Drug	PD 123244-15	GOT1 GOT2	4.37e-05	2	151	2	CID000132851
Disease	Global developmental delay	TMEM94 NBAS TKFC IGF1R UGP2 ACTL6B GOT2	4.65e-06	133	146	7	C0557874
Disease	myelofibrosis (is_implicated_in)	MPL ASXL1 EZH2	6.53e-06	8	146	3	DOID:4971 (is_implicated_in)
Disease	sulfhydryl oxidase 1 measurement	CEP350 C1S	7.27e-05	3	146	2	EFO_0802099
Disease	Intellectual Disability	CHL1 NAA15 PITRM1 TMEM94 AFF3 RNASET2 UGP2 SLC4A10 ACTL6B GOT2	8.16e-05	447	146	10	C3714756
Disease	Seizures	AFF3 SLC8A1 CLPB UGP2 ACTL6B AP3D1 GOT2	1.11e-04	218	146	7	C0036572
Disease	gestational diabetes (biomarker_via_orthology)	INSR IGF1R	2.41e-04	5	146	2	DOID:11714 (biomarker_via_orthology)
Disease	Respiratory Syncytial Virus Infections	ICAM1 SARM1	2.41e-04	5	146	2	C0035235
Disease	17-beta-hydroxysteroid dehydrogenase 14 measurement	SARM1 PLEKHA4	2.41e-04	5	146	2	EFO_0802231
Disease	chronic myelomonocytic leukemia (is_implicated_in)	ASXL1 EZH2	2.41e-04	5	146	2	DOID:0080188 (is_implicated_in)
Disease	acute necrotizing pancreatitis (biomarker_via_orthology)	ICAM1 TLR9 NFKBIA	2.84e-04	26	146	3	DOID:0080998 (biomarker_via_orthology)
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	INSR NR1H3 EZH2 IGF1R	3.08e-04	65	146	4	DOID:0080208 (biomarker_via_orthology)
Disease	MYELODYSPLASTIC SYNDROME	MPL ASXL1 EZH2 UBE2T	3.46e-04	67	146	4	C3463824
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	3.60e-04	6	146	2	C0334488
Disease	Primary Myelofibrosis	MPL EZH2	3.60e-04	6	146	2	C0001815
Disease	clusterin measurement	SARM1 C1S	5.02e-04	7	146	2	EFO_0007655
Disease	diffuse large B-cell lymphoma (is_marker_for)	ICAM1 EZH2	6.68e-04	8	146	2	DOID:0050745 (is_marker_for)
Disease	Developmental delay (disorder)	NBAS TKFC IGF1R	8.15e-04	37	146	3	C0424605
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	ICAM1 INSR ADRA2A IGF1R PIK3R1	8.42e-04	147	146	5	DOID:9352 (biomarker_via_orthology)
Disease	obesity (biomarker_via_orthology)	ICAM1 NR1H3 IGF1R PIK3R1 GOT2	8.42e-04	147	146	5	DOID:9970 (biomarker_via_orthology)
Disease	alcohol dependence (implicated_via_orthology)	INSR IGF1R	8.56e-04	9	146	2	DOID:0050741 (implicated_via_orthology)
Disease	allergic conjunctivitis (is_marker_for)	ICAM1 TLR9	1.07e-03	10	146	2	DOID:11204 (is_marker_for)
Disease	prostate cancer (is_marker_for)	KDM4C EZH2 IGF1R PIK3R1 NFKBIA	1.10e-03	156	146	5	DOID:10283 (is_marker_for)
Disease	sleep disorder (implicated_via_orthology)	INSR IGF1R	1.30e-03	11	146	2	DOID:535 (implicated_via_orthology)
Disease	response to radiation, hearing loss, response to antineoplastic agent	NFKBIA RNASE10 GOT1	1.54e-03	46	146	3	EFO_0004238, GO_0009314, GO_0097327
Disease	chronic kidney disease (implicated_via_orthology)	INSR NR4A1	1.55e-03	12	146	2	DOID:784 (implicated_via_orthology)
Disease	complement component C7 measurement	SARM1 CARD6	1.55e-03	12	146	2	EFO_0008093
Disease	cardiomyopathy (biomarker_via_orthology)	IGF1R GOT1	1.83e-03	13	146	2	DOID:0050700 (biomarker_via_orthology)
Disease	type 2 diabetes mellitus (implicated_via_orthology)	FOXM1 INSR AFF3 IGF1R	1.87e-03	105	146	4	DOID:9352 (implicated_via_orthology)
Disease	hepatocellular carcinoma (is_implicated_in)	TLR9 EZH2 IGF1R NFKBIA PLCG1	2.11e-03	181	146	5	DOID:684 (is_implicated_in)
Disease	diabetic neuropathy (implicated_via_orthology)	INSR IGF1R	2.13e-03	14	146	2	DOID:9743 (implicated_via_orthology)
Disease	mean reticulocyte volume	EP400 KDM4C GNG13 AFF3 VSIG4 URB2 EZH2 CEP350 PIK3R1 ACSF3 C1S	2.15e-03	799	146	11	EFO_0010701
Disease	breast cancer (is_marker_for)	ICAM1 INSR TLR9 IGF1R PLCG1	2.32e-03	185	146	5	DOID:1612 (is_marker_for)
Disease	left ventricular diastolic function measurement	BAG3 IGF1R PIK3R1	2.45e-03	54	146	3	EFO_0008204
Disease	Graves' disease (is_marker_for)	ICAM1 IGF1R	2.45e-03	15	146	2	DOID:12361 (is_marker_for)
Disease	pre-malignant neoplasm (biomarker_via_orthology)	INSR NFKBIA	3.15e-03	17	146	2	DOID:0060071 (biomarker_via_orthology)
Disease	Insulin Resistance	INSR NR4A1 PIK3R1	3.30e-03	60	146	3	C0021655
Disease	Insulin Sensitivity	INSR NR4A1 PIK3R1	3.30e-03	60	146	3	C0920563
Disease	acute kidney failure (biomarker_via_orthology)	ICAM1 IGF1R GOT2	3.46e-03	61	146	3	DOID:3021 (biomarker_via_orthology)
Disease	androstenedione measurement, estrone measurement	GALNT2 PTPRD	3.53e-03	18	146	2	EFO_0007970, EFO_0007972
Disease	Feeding difficulties	UGP2 GOT2	3.53e-03	18	146	2	C0232466
Disease	tea consumption measurement	KDM4C CUL9 PLEKHH3 SLC8A1	3.93e-03	129	146	4	EFO_0010091
Disease	Congenital hernia of foramen of Morgagni	INSR IGF1R	3.93e-03	19	146	2	C0265699
Disease	Congenital hernia of foramen of Bochdalek	INSR IGF1R	3.93e-03	19	146	2	C0265700
Disease	Juvenile Myelomonocytic Leukemia	ASXL1 EZH2	3.93e-03	19	146	2	C0349639
Disease	prostate adenocarcinoma (is_implicated_in)	INSR IGF1R	4.36e-03	20	146	2	DOID:2526 (is_implicated_in)
Disease	Congenital diaphragmatic hernia	INSR IGF1R	4.80e-03	21	146	2	C0235833
Disease	cerebellar cortex volume measurement	PXDNL VSIG10L2	4.80e-03	21	146	2	EFO_0010291

Protein segments in the cluster

Peptide	Gene	Start	Entry
PGPEPELWLQKVSDS	URB2	591	Q14146
GPNLLWPPEKEGDQA	BARGIN	436	Q6ZT62
WLPPLSAIQAPGKVE	AFF3	311	P51826
EPDQPIWTTGLKAPL	ERV3-1	206	Q14264
KPTAEPGQDNPEWLI	EP400	2356	Q96L91
KQQPPEPEWIGDGES	ABCF1	6	Q8NE71
EPPAWGVSPKQKGEE	C1orf167	451	Q5SNV9
EAEELVKGSPAWEPP	CSPG5	41	O95196
SEIPEQGPVIKFWPN	ACER2	236	Q5QJU3
NPAWKELVAQRPPSG	ATP13A3	986	Q9H7F0
AQELLVDPEWPPKPQ	ATP13A3	1191	Q9H7F0
AAKEPVREGAPPNWK	ACTL6B	221	O94805
VLGPNLLWPPEKEGD	SH3BP1	426	Q9Y3L3
LAWKEAQPELQEPQP	DUS1L	441	Q6P1R4
EPAEVPVPEQGWRNK	ACSF3	181	Q4G176
PWEDPDLLQGRNPES	COX16	86	Q9P0S2
QEEEASGQWDPQPPK	CCDC87	406	Q9NVE4
IDQWPAPAPGQTLNL	DENND6B	191	Q8NEG7
WGVSPEDNGNPLNPK	DISP1	791	Q96F81
VGEEWEKAAPTPPAL	ASXL1	926	Q8IXJ9
PVPEGLDLDAWINEP	AP3D1	616	O14617
PDQKDPLWQNPCDDK	NDST3	566	O95803
IKPNPENTGPTLEWD	RANBP2	2211	P49792
EAAGWPKPDPRIFQE	HDHD3	161	Q9BSH5
DIPPDSAVELWKPGA	NR1H3	11	Q13133
RAWTEQLPKASGPPQ	NR4A1	171	P22736
WDDVGLNIPKPPDLL	RELCH	291	Q9P260
GEPQPTIKWRVNGSP	CHL1	356	O00533
EEKVSWAGIGPTPQP	CFAP65	1806	Q6ZU64
LPPGKVRWPDFNQEA	GALNT2	71	Q10471
NSIFLKWPEPENPNG	IGF1R	846	P08069
KPNIEPPENVEWSGA	EZH2	421	Q15910
PREQEAPGTQWPLDE	NLRP1	196	Q9C000
TQDPLGEQQPILWAP	PLK5	191	Q496M5
PPAEGEVVQVKWPDG	KDM4C	936	Q9H3R0
KWIEDGIPKDPFLNP	GNG13	36	Q9P2W3
PQEVPRGSEPWKQQL	NFKBIA	56	P25963
KPLQPGAEVPVVWAQ	LAG3	21	P18627
AGPQPKSWEVKPEAE	MROH6	41	A6NGR9
SQIILKWKPPSDPNG	INSR	636	P06213
TEWNERQPAPALPPK	PIK3R1	296	P27986
GPSWKRLETPEPGQQ	PIMREG	66	Q9BSJ6
EWPPETEVQPRGNQK	NBAS	31	A2RRP1
PNDDGKEEPPTTLLW	NAA15	361	Q9BXJ9
VLEWNGKPLPGATNE	RIMS1	656	Q86UR5
KDPENSPVVLWLNGG	CTSA	71	P10619
VEGSWGPDPPKNLNT	PARP14	11	Q460N5
SQGQLNEKPLPEGWE	ITCH	471	Q96J02
EADGNPPPVIVWTKT	PXDNL	441	A1KZ92
SKQPAQPGWEPGIRA	GSN-AS1	71	Q9NRJ2
PGQLPKPIFWIQAET	IGSF1	126	Q8N6C5
DSQPARAVGKPWPQQ	CARD6	856	Q9BX69
VEAIVKNVPEWNPVP	BTAF1	66	O14981
PLLDEAKAPGQPELW	ANKZF1	481	Q9H8Y5
NVEKEWGLEPFLPPS	FRMPD3	331	Q5JV73
TAPENLNVWPVNGKP	FNDC1	361	Q4ZHG4
PVKNGQETAVPPLWE	CCDC191	466	Q8NCU4
GNPICVQIPWDKNPE	CRY1	311	Q16526
PGLPVWAQNDTEPIV	CBLN4	21	Q9NTU7
NGSWVNEVLGPELPK	C1S	406	P09871
GPWTKAVTPPVKDDN	CEP350	871	Q5VT06
PTGIDPTPEQWKQIA	GOT1	196	P17174
QPWSIPVLPDDKGGL	ANKS6	441	Q68DC2
WLKGERPGPEDEQPS	ATAD3C	396	Q5T2N8
DPLGPDNINWSQFIP	FOXM1	746	Q08050
QTWFQPEIKGGVPPQ	KLHDC1	181	Q8N7A1
PAKFQNPVEPIEPVW	KIAA1210	1676	Q9ULL0
QAQPKCRLWPEQEPE	KNDC1	356	Q76NI1
LVLEAWQKGPNPPGT	CUL9	1896	Q8IWT3
PFALKENWNLNPEPS	ARRDC1-AS1	56	Q9H2J1
LPGPEETLPGQDSWN	CLPB	91	Q9H078
VELAPLPSWQPVGKN	ICAM1	116	P05362
PSWGVDPKEGPQELQ	EMILIN2	166	Q9BXX0
WDEASPQEVPPGNKL	ETV2	6	O00321
SPNLENLKAVWPLDP	ETV3L	346	Q6ZN32
DPAWLQLLQKDSSPP	GPRIN1	6	Q7Z2K8
NGDRDPLPPGWEIKI	BAG3	16	O95817
TEPPPKAALKEWNGV	LIG1	31	P18858
PNWITEKINSGPDPR	SCAF11	1021	Q99590
EVGPPKINGEAQPWL	IRF2BP2	366	Q7Z5L9
PQPLLEKVPESDFQW	PHKA2	736	P46019
KDPRQQAWSPQVPGE	PTX4	251	Q96A99
ILVSWQPPPVEKQNG	PTPRD	626	P23468
KPNPENTGPTLEWDN	RGPD1	1221	P0DJD0
AWVRPDNEAPPKVPQ	MINK1	656	Q8N4C8
KVKQPQEEDWTPPDP	NUTM2B	546	A6NNL0
KVKQPQEEDWTPPDP	NUTM2E	546	B1AL46
PEEPLLEEEEKQWGP	RTN2	231	O75298
IDPNLKPSELAPGWK	RTP2	31	Q5QGT7
EEPEPGFKRLAWGQP	QARS1	621	P47897
IKPNPENTGPTLEWD	RGPD4	1236	Q7Z3J3
EENDEPDVKPWLAGP	POLR3D	191	P05423
PGVPWKGLQNIDPEN	TNRC6C	1391	Q9HCJ0
KQPPWEFLQVLEPGA	SPAG8	241	Q99932
WSLIPEKGLPEDDPD	PLEKHH3	81	Q7Z736
PENVWNGIPKLDKSP	TDRD6	2071	O60522
AWDAGIAPPVLPQDE	PLEKHA4	751	Q9H4M7
GEGAEPLKVPVWEPQ	NTHL1	76	P78549
AVGQAPDWTQPLDLP	PKDREJ	266	Q9NTG1
LGPENPKIAKDPSWI	PITRM1	1021	Q5JRX3
LNEEEPPGGQDPWKL	RNF26	356	Q9BY78
PPGGQDPWKLLKEQE	RNF26	361	Q9BY78
GNWENLPSPISPDIK	SCYL2	131	Q6P3W7
DSPGKAIRGPQQPIW	TANK	356	Q92844
WDKDPPGERRPQQSQ	DIP2C-AS1	6	Q8N8Z3
IPPDPGTGDLEKQDW	PLB1	81	Q6P1J6
DKGTDERQPWPSEPL	PLA2G3	466	Q9NZ20
PLNSISEPKGNPLAW	DZIP1	446	Q86YF9
QAWAQQLKEPVPPGD	SPTBN5	2166	Q9NRC6
PTGVDPRPEQWKEIA	GOT2	216	P00505
PQPAEPRCEINDQKW	ADRA2A	196	P08913
PQWSEEREEKGPPQS	ANHX	236	E9PGG2
PPQILLWDPSGQKQG	CLCA1	526	A8K7I4
IPGWVVNGEIEANPP	CLCA4	701	Q14CN2
PGEQPSPKQEVWLAN	RNASET2	216	O00584
LQWPKEQPFGEGVPL	UBA3	256	Q8TBC4
GAGDPEPDLWIIQPQ	SIRPB2	151	Q5JXA9
PSVDWGKIQRPPEDS	UGP2	71	Q16851
QEEPKGAAWPTPILA	ZSCAN10	221	Q96SZ4
QLQPVDPWPEGQSQK	ZSCAN20	161	P17040
LQDPWVPTGPGAVQK	TNIP3	276	Q96KP6
SNKEVVQPGWPEDPI	RNASE10	71	Q5GAN6
SQEGPKDPEAWSRPQ	RIPK3	496	Q9Y572
KNIVPIIDGFEWPEP	SARM1	651	Q6SZW1
PPTEEIWVENKTPDG	TCERG1	131	O14776
VDKQGILSWPNPSPE	TMEM94	416	Q12767
VWLQPGDLAPAPVDT	TLR9	446	Q9NR96
IPLPQWKANPETDPE	SGF29	211	Q96ES7
SWIKQEEEPQVGAPP	ZNF398	231	Q8TD17
LDQVTVLPPGEWDPS	SLC4A10	421	Q6U841
KPEGQSPVKAEWPSE	UBE2O	891	Q9C0C9
SPEPVKPEQGFVWQE	ZNF710	236	Q8N1W2
TEPPPGITCWQDKDQ	UBE2T	16	Q9NPD8
VVDNGLNPVWPAKPF	PLCG1	1131	P19174
KPLPLEEQVEWNPQL	ACP6	66	Q9NPH0
QPGELQISWEEPAPE	MPL	146	P40238
PESVTGPWKGDVNLP	VSIG4	26	Q9Y279
PPEGVPVAEVEWLKN	UNC5B	176	Q8IZJ1
GEQAQDWDALPPKRP	EMG1	16	Q92979
LPPEIQAWVGAQSPK	ZSCAN22	101	P10073
WKVVAEQPVGGTDPP	nan	131	Q6ZS52
GPCPEWELKAVPSQQ	ZNF74	111	Q16587
PGPLKNSSDWKIPQD	STK4	416	Q13043
SAEQWLPLVEVKPPQ	TARBP1	1511	Q13395
PLDPKGTTQIDPNWV	THBS2	966	P35442
WKLLPEQAAPPGAGD	TIGD5	246	Q53EQ6
ALWGPDLQGPEQSPN	ZNF629	6	Q9UEG4
GEKVDPGLPLEKQPW	SHE	381	Q5VZ18
AARAIQEWLKEGPPP	TKFC	411	Q3LXA3
EPPATLGWLDEQQQP	VSIG10L2	441	P0DP72
VPNGEIPDCKWNKSP	TTLL1	356	O95922
QPGVPWKGIQNIDPE	TNRC6B	1481	Q9UPQ9
SDQWPSPRGKQEPQV	ZNF541	861	Q9H0D2
SETEPPLWKESPGQL	LEG1	26	Q6P5S2
LPIWEPQDPSFGDKI	SLC8A1	61	P32418
QEEGSEQWKPVTPGP	MYOM3	841	Q5VTT5
KSEQQVEEEPGWPHP	MYRIP	251	Q8NFW9
QGPAKPEVLSIQWPG	NECAB1	166	Q8N987
KNPEPWETVDPTVPQ	NMES1	46	Q9C002
WEDPRLQNPAITGPA	NEDD4L	576	Q96PU5