Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionMAP kinase activity

MAPK15 MAPK1 MAPK3

8.41e-05161093GO:0004707
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR1 ITPR2

8.83e-0531092GO:0005220
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF536 ZBTB2 ZNF584 ZFP30 ZNF280C ZNF275 REST ZNF692 ZNF490 ZSCAN20 SALL1 ZNF780A ZNF648 ZNF81 NR1H4 ZFP62 ZNF574

4.03e-04124410917GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF536 ZBTB2 ZNF584 ZFP30 ZNF280C ZNF275 REST ZNF692 ZNF490 ZSCAN20 SALL1 ZNF780A ZNF648 ZNF81 NR1H4 ZFP62 ZNF574

5.15e-04127110917GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF536 ZBTB2 ZNF584 ZFP30 ZNF280C ZNF275 REST ZNF692 ZNF490 ZSCAN20 SALL1 ZNF780A ZNF648 ZBTB10 ZNF81 NR1H4 ZFP62 ZNF574

6.13e-04141210918GO:0000981
GeneOntologyMolecularFunctioncalcium channel activity

CALHM1 CALHM3 ITPR1 ITPR2 CNGA2

7.11e-041291095GO:0005262
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

ITPR1 ITPR2 CNGA2

7.66e-04331093GO:0005217
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF536 ZBTB2 ZNF584 ZFP30 ZNF280C ZNF275 REST ZNF692 ZNF490 ZSCAN20 SALL1 ZNF780A ZNF648 ZBTB10 ZNF81 NR1H4 ZFP62 ZNF574

8.97e-04145910918GO:0000977
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

CALHM1 ITPR1 ITPR2 SCNN1G CNGA2

1.03e-031401095GO:0099094
GeneOntologyCellularComponentESCRT-0 complex

STAM2 STAM

7.76e-0531072GO:0033565
DomainZINC_FINGER_C2H2_2

ZNF536 ZBTB2 ZNF584 ZFP30 ZNF280C ZNF275 REST ZNF692 ZNF490 ZNF462 ZNF800 ZSCAN20 SALL1 ZNF780A ZNF648 ZBTB10 ZNF81 ZFP62 ZNF574

9.03e-0877510819PS50157
DomainZINC_FINGER_C2H2_1

ZNF536 ZBTB2 ZNF584 ZFP30 ZNF280C ZNF275 REST ZNF692 ZNF490 ZNF462 ZNF800 ZSCAN20 SALL1 ZNF780A ZNF648 ZBTB10 ZNF81 ZFP62 ZNF574

9.40e-0877710819PS00028
DomainZnf_C2H2

ZNF536 ZBTB2 ZNF584 ZFP30 ZNF280C ZNF275 REST ZNF692 ZNF490 ZNF462 ZNF800 ZSCAN20 SALL1 ZNF780A ZNF648 ZBTB10 ZNF81 ZFP62 ZNF574

1.63e-0780510819IPR007087
DomainZnF_C2H2

ZNF536 ZBTB2 ZNF584 ZFP30 ZNF280C ZNF275 REST ZNF692 ZNF490 ZNF462 ZNF800 ZSCAN20 SALL1 ZNF780A ZNF648 ZBTB10 ZNF81 ZFP62 ZNF574

1.72e-0780810819SM00355
Domain-

ZNF536 ZBTB2 ZNF584 ZFP30 REST ZNF692 ZNF490 ZNF462 ZNF800 ZSCAN20 SALL1 ZNF780A ZNF648 ZBTB10 ZNF81 ZFP62 ZNF574

3.49e-07679108173.30.160.60
Domainzf-C2H2

ZNF536 ZBTB2 ZNF584 ZFP30 ZNF275 REST ZNF692 ZNF490 ZNF462 ZSCAN20 SALL1 ZNF780A ZNF648 ZBTB10 ZNF81 ZFP62 ZNF574

4.64e-0769310817PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF536 ZBTB2 ZNF584 ZFP30 REST ZNF692 ZNF490 ZNF462 ZNF800 ZSCAN20 SALL1 ZNF780A ZNF648 ZBTB10 ZNF81 ZFP62 ZNF574

4.73e-0769410817IPR013087
DomainZnf_C2H2-like

ZNF536 ZBTB2 ZNF584 ZFP30 ZNF280C REST ZNF692 ZNF490 ZNF462 ZNF800 ZSCAN20 SALL1 ZNF780A ZNF648 ZBTB10 ZNF81 ZFP62 ZNF574

6.71e-0779610818IPR015880
DomainFAM26

CALHM1 CALHM3 CALHM4

3.71e-0661083IPR029569
DomainCa_hom_mod

CALHM1 CALHM3 CALHM4

3.71e-0661083PF14798
DomainMAPK_ERK1/2

MAPK1 MAPK3

3.31e-0521082IPR008349
DomainARPC1

ARPC1A ARPC1B

3.31e-0521082IPR017383
DomainMAP_kinase_CS

MAPK15 MAPK1 MAPK3

3.98e-05121083IPR003527
DomainMAPK

MAPK15 MAPK1 MAPK3

3.98e-05121083PS01351
DomainInsP3_rcpt-bd

ITPR1 ITPR2

9.90e-0531082IPR000493
DomainRDM

RFPL4AL1 RFPL4A

3.28e-0451082PF11002
DomainRDM_domain_RFPL

RFPL4AL1 RFPL4A

3.28e-0451082IPR022723
DomainRIH_assoc

ITPR1 ITPR2

4.89e-0461082PF08454
DomainRIH_assoc-dom

ITPR1 ITPR2

4.89e-0461082IPR013662
DomainRIH_dom

ITPR1 ITPR2

4.89e-0461082IPR000699
DomainIns145_P3_rcpt

ITPR1 ITPR2

4.89e-0461082IPR014821
DomainRyanodine_recept-rel

ITPR1 ITPR2

4.89e-0461082IPR015925
Domain-

ITPR1 ITPR2

4.89e-04610821.25.10.30
DomainRYDR_ITPR

ITPR1 ITPR2

4.89e-0461082PF01365
DomainIns145_P3_rec

ITPR1 ITPR2

4.89e-0461082PF08709
DomainZnf_MYM

ZMYM1 ZMYM3

6.83e-0471082IPR010507
Domainzf-FCS

ZMYM1 ZMYM3

6.83e-0471082PF06467
DomainTRASH_dom

ZMYM1 ZMYM3

9.07e-0481082IPR011017
DomainTRASH

ZMYM1 ZMYM3

9.07e-0481082SM00746
DomainVHS

STAM2 STAM

1.16e-0391082PF00790
DomainVHS

STAM2 STAM

1.16e-0391082PS50179
DomainVHS

STAM2 STAM

1.16e-0391082SM00288
DomainVHS_dom

STAM2 STAM

1.16e-0391082IPR002014
DomainMIR

ITPR1 ITPR2

1.45e-03101082PS50919
DomainMIR

ITPR1 ITPR2

1.45e-03101082PF02815
DomainMIR

ITPR1 ITPR2

1.45e-03101082SM00472
DomainITAM_1

STAM2 STAM

1.45e-03101082PS51055
DomainMIR_motif

ITPR1 ITPR2

1.45e-03101082IPR016093
DomainPhos_immunorcpt_sig_ITAM

STAM2 STAM

1.45e-03101082IPR003110
DomainMethyl_CpG_DNA-bd

MBD1 SETDB1

1.76e-03111082IPR001739
DomainMBD

MBD1 SETDB1

1.76e-03111082PF01429
DomainDNA-bd_dom

MBD1 SETDB1

1.76e-03111082IPR016177
DomainMBD

MBD1 SETDB1

1.76e-03111082SM00391
DomainMBD

MBD1 SETDB1

1.76e-03111082PS50982
DomainGrpE_coiled_coil

GRPEL2 DNAH8

2.11e-03121082IPR013805
DomainUIM

STAM2 STAM

4.77e-03181082PF02809
DomainKRAB

ZNF584 ZFP30 ZNF275 ZNF490 ZSCAN20 ZNF780A ZNF81

5.63e-033691087SM00349
DomainKRAB

ZNF584 ZFP30 ZNF275 ZNF490 ZSCAN20 ZNF780A ZNF81

5.71e-033701087IPR001909
DomainApc4_WD40_dom

EML6 WDR3

5.88e-03201082IPR024977
DomainANAPC4_WD40

EML6 WDR3

5.88e-03201082PF12894
DomainUIM

STAM2 STAM

6.48e-03211082SM00726
PathwayREACTOME_SENSORY_PERCEPTION_OF_SALTY_TASTE

CALHM1 CALHM3 SCNN1G

2.98e-066763M42526
PathwayKEGG_MEDICUS_REFERENCE_ERK_RSK_SIGNALING

RPS6KA1 MAPK1 MAPK3

2.98e-066763M47936
PathwaySIG_BCR_SIGNALING_PATHWAY

ITPR1 ITPR2 MAPK1 MAPK3 VAV1

4.60e-0646765M8626
PathwayREACTOME_RSK_ACTIVATION

RPS6KA1 MAPK1 MAPK3

5.19e-067763M27369
PathwaySA_B_CELL_RECEPTOR_COMPLEXES

RPS6KA1 MAPK1 MAPK3 VAV1

7.64e-0624764M17200
PathwayREACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS

ARPC1A ARPC1B ITPR1 ITPR2 MAPK1 MAPK3 VAV1

1.16e-05143767M27107
PathwayREACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES

ARPC1A ARPC1B MAPK1 MAPK3

3.20e-0534764MM15265
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4

REST GEM MAPK1 MAPK3

3.20e-0534764M46422
PathwayKEGG_LONG_TERM_POTENTIATION

RPS6KA1 ITPR1 ITPR2 MAPK1 MAPK3

3.67e-0570765M3115
PathwayREACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES

ARPC1A ARPC1B MAPK1 MAPK3

4.03e-0536764M27549
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

RPS6KA1 ITPR1 ITPR2 VAV1

4.03e-0536764M1315
PathwayBIOCARTA_ERK5_PATHWAY

RPS6KA1 MAPK1 MAPK3

5.25e-0514763MM1481
PathwayBIOCARTA_ERK5_PATHWAY

RPS6KA1 MAPK1 MAPK3

5.25e-0514763M16811
PathwayREACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK

RPS6KA1 MAPK1 MAPK3

8.02e-0516763MM15477
PathwayWP_IL7_SIGNALING_PATHWAY

STAM2 STAM MAPK1 MAPK3

8.21e-0543764MM15864
PathwayWP_IL11_SIGNALING

RPS6KA1 PTPA MAPK1 MAPK3

8.99e-0544764M39716
PathwayWP_IL2_SIGNALING_PATHWAY

STAM2 STAM MAPK1 MAPK3 VAV1

1.04e-0487765MM15915
PathwayWP_MFAP5_EFFECT_ON_PERMEABILITY_AND_MOTILITY_OF_ENDOTHELIAL_CELLS_VIA_CYTOSKELETON_REARRANGEMENT

ITPR1 MAPK1 MAPK3

1.16e-0418763M39808
PathwayREACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK

RPS6KA1 MAPK1 MAPK3

1.16e-0418763M657
PathwayBIOCARTA_MPR_PATHWAY

RPS6KA1 MAPK1 MAPK3

1.16e-0418763MM1407
PathwayREACTOME_SIGNAL_TRANSDUCTION_BY_L1

ITGA9 MAPK1 MAPK3

1.37e-0419763MM15113
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 VAV1

1.37e-0419763M47733
PathwayREACTOME_ERK_MAPK_TARGETS

RPS6KA1 MAPK1 MAPK3

1.37e-0419763MM14780
PathwayKEGG_REGULATION_OF_ACTIN_CYTOSKELETON

ARPC1A ITGA9 ARPC1B FGF2 MAPK1 MAPK3 VAV1

1.47e-04213767M18306
PathwayBIOCARTA_CREB_PATHWAY

RPS6KA1 MAPK1 MAPK3

1.61e-0420763MM1520
PathwayWP_SEROTONIN_RECEPTOR_2_AND_ELKSRFGATA4_SIGNALING

ITPR1 MAPK1 MAPK3

1.61e-0420763M39485
PathwayREACTOME_TRANSCRIPTIONAL_AND_POST_TRANSLATIONAL_REGULATION_OF_MITF_M_EXPRESSION_AND_ACTIVITY

RPS6KA1 MC5R MAPK1 MAPK3

1.61e-0451764M48267
PathwayKEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS

ARPC1A ARPC1B MAPK1 MAPK3 VAV1

1.66e-0496765M16121
PathwayREACTOME_LEISHMANIA_INFECTION

ARPC1A ARPC1B ITPR1 ITPR2 MAPK1 MAPK3 VAV1

1.75e-04219767M29836
PathwayBIOCARTA_MPR_PATHWAY

RPS6KA1 MAPK1 MAPK3

1.87e-0421763M13883
PathwayREACTOME_SIGNAL_TRANSDUCTION_BY_L1

ITGA9 MAPK1 MAPK3

1.87e-0421763M878
PathwayBIOCARTA_CREB_PATHWAY

RPS6KA1 MAPK1 MAPK3

2.15e-0422763M9070
PathwayREACTOME_ERK_MAPK_TARGETS

RPS6KA1 MAPK1 MAPK3

2.15e-0422763M13408
PathwayBIOCARTA_IGF1R_PATHWAY

RPS6KA1 MAPK1 MAPK3

2.15e-0422763MM1438
PathwayREACTOME_NPAS4_REGULATES_EXPRESSION_OF_TARGET_GENES

GEM MAPK1 MAPK3

2.15e-0422763M46437
PathwayPID_FGF_PATHWAY

RPS6KA1 FGF2 MAPK1 MAPK3

2.16e-0455764M276
PathwayPID_IL2_1PATHWAY

STAM2 STAM MAPK1 MAPK3

2.16e-0455764M122
PathwayBIOCARTA_IGF1R_PATHWAY

RPS6KA1 MAPK1 MAPK3

2.47e-0423763M19613
PathwayBIOCARTA_BAD_PATHWAY

RPS6KA1 MAPK1 MAPK3

2.81e-0424763MM1467
PathwayWP_KIT_RECEPTOR_SIGNALING

RPS6KA1 MAPK1 MAPK3 VAV1

2.84e-0459764M39350
PathwayREACTOME_INTERLEUKIN_17_SIGNALING

RPS6KA1 NOD1 MAPK1 MAPK3

2.84e-0459764MM15128
PathwayBIOCARTA_PELP1_PATHWAY

MAPK1 MAPK3

2.84e-045762MM1575
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_USP8_TO_EGFR_ERK_ACTH_SIGNALING_PATHWAY

MAPK1 MAPK3

2.84e-045762M49028
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_BRAF_TO_ERK_SIGNALING_PATHWAY

MAPK1 MAPK3

2.84e-045762M49016
PathwayKEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_ERK_SIGNALING_PATHWAY

MAPK1 MAPK3

2.84e-045762M49004
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY

ITPR1 ITPR2

2.84e-045762M49000
PathwayWP_TCA_CYCLE_NUTRIENT_USE_AND_INVASIVENESS_OF_OVARIAN_CANCER

MAPK1 MAPK3

2.84e-045762M39621
PathwayWP_WNT_SIGNALING_PATHWAY

ARRB2 SALL1 MAPK1 MAPK3 FZD2

3.14e-04110765MM15977
PathwayPID_LYMPH_ANGIOGENESIS_PATHWAY

RPS6KA1 MAPK1 MAPK3

3.18e-0425763M274
PathwayREACTOME_TRANSCRIPTIONAL_AND_POST_TRANSLATIONAL_REGULATION_OF_MITF_M_EXPRESSION_AND_ACTIVITY

RPS6KA1 MAPK1 MAPK3

3.18e-0425763MM17240
PathwayBIOCARTA_BAD_PATHWAY

RPS6KA1 MAPK1 MAPK3

3.18e-0425763M85
PathwayREACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION

RPS6KA1 REST MAPK1 MAPK3

3.23e-0461764M152
PathwayKEGG_OOCYTE_MEIOSIS

RPS6KA1 ITPR1 ITPR2 MAPK1 MAPK3

3.56e-04113765M16817
PathwayPID_ALK1_PATHWAY

ARRB2 MAPK1 MAPK3

3.58e-0426763M185
PathwayREACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS

ARPC1A ARPC1B MAPK1 MAPK3 VAV1

3.70e-04114765MM14814
PathwayBIOCARTA_ERK_PATHWAY

RPS6KA1 MAPK1 MAPK3

4.01e-0427763M287
PathwayBIOCARTA_GH_PATHWAY

RPS6KA1 MAPK1 MAPK3

4.01e-0427763M9043
PathwayREACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION

RPS6KA1 MAPK1 MAPK3

4.01e-0427763MM14779
PathwayREACTOME_PARASITE_INFECTION

ARPC1A ARPC1B MAPK1 MAPK3 VAV1

4.01e-04116765M29843
PathwayBIOCARTA_SAM68_PATHWAY

MAPK1 MAPK3

4.24e-046762MM1567
PathwayBIOCARTA_SAM68_PATHWAY

MAPK1 MAPK3

4.24e-046762M22052
PathwayBIOCARTA_PELP1_PATHWAY

MAPK1 MAPK3

4.24e-046762M22062
PathwayREACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY

MAPK1 MAPK3

4.24e-046762M27559
PathwayREACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY

MAPK1 MAPK3

4.24e-046762MM15273
PathwayKEGG_MEDICUS_PATHOGEN_SHIGELLA_OSPF_TO_TLR2_4_MAPK_SIGNALING_PATHWAY

MAPK1 MAPK3

4.24e-046762M47766
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2

4.24e-046762M47960
PathwayREACTOME_SIGNALING_BY_NODAL

MAPK1 MAPK3

4.24e-046762MM14517
PathwayREACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING

RPS6KA1 MAPK1 MAPK3

4.48e-0428763M837
PathwayBIOCARTA_ERK_PATHWAY

RPS6KA1 MAPK1 MAPK3

4.48e-0428763MM1391
PathwayREACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES

RPS6KA1 MAPK1 MAPK3

4.48e-0428763MM15132
PathwayWP_IL5_SIGNALING_PATHWAY

RPS6KA1 MAPK1 MAPK3 VAV1

4.89e-0468764MM15930
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING

FGF2 MAPK1 MAPK3

4.97e-0429763M27528
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING

FGF2 MAPK1 MAPK3

4.97e-0429763MM15253
PathwayREACTOME_TOLL_LIKE_RECEPTOR_4_TLR4_CASCADE

RPS6KA1 NOD1 MAPK1 MAPK3 LY86

5.06e-04122765MM14640
PathwayKEGG_LONG_TERM_DEPRESSION

ITPR1 ITPR2 MAPK1 MAPK3

5.46e-0470764M8232
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

STAM2 RPS6KA1 REST STAM ITPR1 ITPR2 FGF2 MAPK1 MAPK3 VAV1

5.47e-045327610M27870
PathwayREACTOME_BACTERIAL_INFECTION_PATHWAYS

STAM2 STAM MAPK1 MAPK3

5.77e-0471764M48033
PathwayREACTOME_INTERLEUKIN_17_SIGNALING

RPS6KA1 NOD1 MAPK1 MAPK3

5.77e-0471764M27382
PathwayREACTOME_IFNG_SIGNALING_ACTIVATES_MAPKS

MAPK1 MAPK3

5.92e-047762MM17070
PathwayREACTOME_SIGNALING_BY_LTK_IN_CANCER

MAPK1 MAPK3

5.92e-047762M48255
PathwayREACTOME_SUPPRESSION_OF_APOPTOSIS

MAPK1 MAPK3

5.92e-047762M29815
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR4_SIGNALING

FGF2 MAPK1 MAPK3

6.07e-0431763M27529
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR4_SIGNALING

FGF2 MAPK1 MAPK3

6.07e-0431763MM15254
PathwayREACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES

RPS6KA1 MAPK1 MAPK3

6.07e-0431763M15195
PathwayWP_4P163_COPY_NUMBER_VARIATION

FGF2 MAPK1 MAPK3

6.67e-0432763M48083
PathwayREACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS

ARRB2 MAPK1 MAPK3

6.67e-0432763M861
PathwayREACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS

ARRB2 MAPK1 MAPK3

6.67e-0432763MM15148
PathwayPID_WNT_NONCANONICAL_PATHWAY

SETDB1 ARRB2 FZD2

6.67e-0432763M23
PathwayWP_ALZHEIMERS_DISEASE

ITPR1 ITPR2 MAPK1 MAPK3

6.75e-0474764MM15962
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR1_SIGNALING

FGF2 MAPK1 MAPK3

7.31e-0433763M27526
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR2_SIGNALING

FGF2 MAPK1 MAPK3

7.31e-0433763MM15252
PathwayWP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION

ITPR1 MAPK1 MAPK3

7.31e-0433763M39745
PathwayBIOCARTA_GH_PATHWAY

RPS6KA1 MAPK1 MAPK3

7.31e-0433763MM1404
PathwayBIOCARTA_STAT3_PATHWAY

MAPK1 MAPK3

7.86e-048762MM1576
PathwayBIOCARTA_STAT3_PATHWAY

MAPK1 MAPK3

7.86e-048762M22063
PathwayREACTOME_IFNG_SIGNALING_ACTIVATES_MAPKS

MAPK1 MAPK3

7.86e-048762M48010
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PROK2_TO_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY

MAPK1 MAPK3

7.86e-048762M47642
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PROKR2_TO_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY

MAPK1 MAPK3

7.86e-048762M47643
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR2_SIGNALING

FGF2 MAPK1 MAPK3

7.99e-0434763M27527
PathwayPID_MAPK_TRK_PATHWAY

RPS6KA1 MAPK1 MAPK3

7.99e-0434763M270
Pubmed

Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression.

FGF2 MAPK1 MAPK3

2.99e-083109318703672
Pubmed

Reactive oxygen species regulate prosurvival ERK1/2 signaling and bFGF expression in gliosis within the retina.

FGF2 MAPK1 MAPK3

2.99e-083109322956616
Pubmed

Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.

ARRB2 MAPK1 MAPK3

2.99e-083109326324936
Pubmed

Phosphorylation of β-arrestin2 at Thr383 by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs.

ARRB2 MAPK1 MAPK3

2.99e-083109328169830
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ZNF536 ZNF462 SETDB1 ARRB2 SALL1 ZBTB10 ANKRD17 ANKRD28 ANKRD52 ZMYM3 TANGO6

8.86e-084181091134709266
Pubmed

Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.

ITPR1 ITPR2 MAPK1 MAPK3

8.92e-0814109434630045
Pubmed

Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription.

ARRB2 MAPK1 MAPK3

1.20e-074109318006496
Pubmed

Phosphorylation of KIBRA by the extracellular signal-regulated kinase (ERK)-ribosomal S6 kinase (RSK) cascade modulates cell proliferation and migration.

RPS6KA1 MAPK1 MAPK3

1.20e-074109324269383
Pubmed

Basic fibroblast growth factor antagonizes activin A-mediated growth inhibition and hemoglobin synthesis in K562 cells by activating ERK1/2 and deactivating p38 MAP kinase.

FGF2 MAPK1 MAPK3

1.20e-074109315249224
Pubmed

Essential role for ERK2 mitogen-activated protein kinase in placental development.

RPS6KA1 MAPK1 MAPK3

1.20e-074109314622137
Pubmed

SOCS-3 antagonises the proliferative and migratory effects of fibroblast growth factor-2 in prostate cancer by inhibition of p44/p42 MAPK signalling.

FGF2 MAPK1 MAPK3

1.20e-074109320335309
Pubmed

Regulation of alveolar epithelial Na+ channels by ERK1/2 in chlorine-breathing mice.

SCNN1G MAPK1 MAPK3

1.20e-074109321997487
Pubmed

Canonical FGFs Prevent Osteogenic Lineage Commitment and Differentiation of Human Bone Marrow Stromal Cells Via ERK1/2 Signaling.

FGF2 MAPK1 MAPK3

1.20e-074109327305863
Pubmed

Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2.

ARRB2 MAPK1 MAPK3

1.20e-074109315355986
Pubmed

Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neurons.

ARRB2 MAPK1 MAPK3

1.20e-074109319279269
Pubmed

Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.

ARRB2 MAPK1 MAPK3

1.20e-074109314711824
Pubmed

ERK1/2-p90RSK-mediated phosphorylation of Na+/H+ exchanger isoform 1. A role in ischemic neuronal death.

RPS6KA1 MAPK1 MAPK3

1.20e-074109317664275
Pubmed

Regulation of protein kinase A activity by p90 ribosomal S6 kinase 1.

RPS6KA1 MAPK1 MAPK3

1.20e-074109319808666
Pubmed

The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation.

ARRB2 MAPK1 MAPK3

2.98e-075109322174878
Pubmed

Differential effects of beta-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2.

ARRB2 MAPK1 MAPK3

2.98e-075109317442737
Pubmed

Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells.

FGF2 MAPK1 MAPK3

2.98e-075109320478381
Pubmed

The Vascular Endothelial Growth Factor-A phosphorylates Murine Double Minute-2 on its Serine 166 via the Extracellular Signal-Regulated Kinase 1/2 and p90 Ribosomal S6 Kinase in primary human endothelial cells.

RPS6KA1 MAPK1 MAPK3

2.98e-075109327591897
Pubmed

Role for engagement of β-arrestin2 by the transactivated EGFR in agonist-specific regulation of δ receptor activation of ERK1/2.

ARRB2 MAPK1 MAPK3

2.98e-075109326211551
Pubmed

Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo.

RPS6KA1 MAPK1 MAPK3

2.98e-07510939915826
Pubmed

Factor Xa induces tissue factor expression in endothelial cells by P44/42 MAPK and NF-κB-dependent pathways.

F10 MAPK1 MAPK3

2.98e-075109320451919
Pubmed

Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.

RPS6KA1 MAPK1 MAPK3

5.95e-076109312832467
Pubmed

EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors.

RPS6KA1 MAPK1 MAPK3

5.95e-076109322865467
Pubmed

FGF and ERK signaling coordinately regulate mineralization-related genes and play essential roles in osteocyte differentiation.

FGF2 MAPK1 MAPK3

5.95e-076109321678127
Pubmed

Fibroblast growth factor-2 and -4 promote the proliferation of bone marrow mesenchymal stem cells by the activation of the PI3K-Akt and ERK1/2 signaling pathways.

FGF2 MAPK1 MAPK3

5.95e-076109318788932
Pubmed

The MAP kinase ERK5 binds to and phosphorylates p90 RSK.

RPS6KA1 MAPK1 MAPK3

5.95e-076109316626623
Pubmed

Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases.

RPS6KA1 MAPK1 MAPK3

5.95e-07610938939914
Pubmed

GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner.

ARRB2 MAPK1 MAPK3

1.04e-067109320886089
Pubmed

Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs.

RPS6KA1 MAPK1 MAPK3

1.04e-067109312594221
Pubmed

2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline.

FGF2 MAPK1 MAPK3

1.04e-067109326075383
Pubmed

The basic domain of HIV-tat transactivating protein is essential for its targeting to lipid rafts and regulating fibroblast growth factor-2 signaling in podocytes isolated from children with HIV-1-associated nephropathy.

FGF2 MAPK1 MAPK3

1.04e-067109324578133
Pubmed

Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma.

FGF2 MAPK1 MAPK3

1.04e-067109321292498
Pubmed

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.

RPS6KA1 MAPK1 MAPK3

1.04e-067109315342917
Pubmed

The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.

ARRB2 MAPK1 MAPK3

1.66e-068109312473660
Pubmed

Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains.

ANKRD44 ANKRD28 ANKRD52

1.66e-068109318186651
Pubmed

B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK.

PTPA MAPK1 MAPK3

2.48e-069109316456541
Pubmed

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.

ANKRD44 ANKRD28 ANKRD52

2.48e-069109321187329
Pubmed

Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling.

FGF2 MAPK1 MAPK3

3.54e-0610109326719333
Pubmed

Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits adhesion of human endometriotic epithelial and stromal cells through suppression of integrin-mediated mechanisms.

ARRB2 MAPK1 MAPK3

3.54e-0610109323242524
Pubmed

Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins.

RPS6KA1 MAPK1 MAPK3

3.54e-0610109319114553
Pubmed

Characterization of nuclear factors modulating the apolipoprotein D promoter during growth arrest: implication of PARP-1, APEX-1 and ERK1/2 catalytic activities.

IFI16 MAPK1 MAPK3

4.85e-0611109320493910
Pubmed

Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation.

ANKRD44 ANKRD28 ANKRD52

6.45e-0612109335512830
Pubmed

FGF signaling is required for anterior but not posterior specification of the murine liver bud.

FGF2 MAPK1 MAPK3

6.45e-0612109325302779
Pubmed

HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway.

FGF2 MAPK1 MAPK3

6.45e-0612109316436505
Pubmed

Inactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors.

FGF2 MAPK1 MAPK3

8.37e-0613109320851768
Pubmed

Expression and activation of mitogen-activated protein kinase in the human endometrium during the menstrual cycle.

MAPK1 MAPK3

9.73e-062109216796978
Pubmed

Mitogen-activated protein kinase phosphorylates and regulates the HIV-1 Vif protein.

MAPK1 MAPK3

9.73e-06210929792705
Pubmed

Curcumin potentiates antitumor activity of cisplatin in bladder cancer cell lines via ROS-mediated activation of ERK1/2.

MAPK1 MAPK3

9.73e-062109227564099
Pubmed

A role for ERK2 in reconsolidation of fear memories in mice.

MAPK1 MAPK3

9.73e-062109216504549
Pubmed

MEK1-ERK1/2 signaling regulates the cardiomyocyte non-sarcomeric actin cytoskeletal network.

MAPK1 MAPK3

9.73e-062109237999644
Pubmed

Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin.

MAPK1 MAPK3

9.73e-062109218070930
Pubmed

Genistein induces G2/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells.

MAPK1 MAPK3

9.73e-062109218224451
Pubmed

Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence.

MAPK1 MAPK3

9.73e-062109223993963
Pubmed

Mechanical stress promotes angiogenesis through fibroblast exosomes.

MAPK1 MAPK3

9.73e-062109232962863
Pubmed

Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells.

MAPK1 MAPK3

9.73e-062109219801509
Pubmed

Protein-peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase.

RPS6KA1 MAPK1

9.73e-062109223519423
Pubmed

The ERK phosphorylation levels in the amygdala predict anxiety symptoms in humans and MEK/ERK inhibition dissociates innate and learned defensive behaviors in rats.

MAPK1 MAPK3

9.73e-062109234316004
Pubmed

Inhibition of the ERK pathway prevents HIVgp120-induced REM sleep increase.

MAPK1 MAPK3

9.73e-062109211532249
Pubmed

A novel protein encoded by circUBE4B promotes progression of esophageal squamous cell carcinoma by augmenting MAPK/ERK signaling.

UBE4B MAPK1

9.73e-062109237264022
Pubmed

Lipopolysaccharide can modify differentiation and immunomodulatory potential of periodontal ligament stem cells via ERK1,2 signaling.

MAPK1 MAPK3

9.73e-062109228295277
Pubmed

ERK1/2 controls Na,K-ATPase activity and transepithelial sodium transport in the principal cell of the cortical collecting duct of the mouse kidney.

MAPK1 MAPK3

9.73e-062109215456767
Pubmed

Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells.

MAPK1 MAPK3

9.73e-062109212810726
Pubmed

Identification of a JAK2-independent pathway regulating growth hormone (GH)-stimulated p44/42 mitogen-activated protein kinase activity. GH activation of Ral and phospholipase D is Src-dependent.

MAPK1 MAPK3

9.73e-062109212218045
Pubmed

Long non-coding RNA Gm2199 rescues liver injury and promotes hepatocyte proliferation through the upregulation of ERK1/2.

MAPK1 MAPK3

9.73e-062109229789577
Pubmed

Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation.

MAPK1 MAPK3

9.73e-062109227528403
Pubmed

Activation of spinal extracellular signal-regulated kinases (ERK) 1/2 is associated with the development of visceral hyperalgesia of the bladder.

MAPK1 MAPK3

9.73e-062109221705143
Pubmed

ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis.

MAPK1 MAPK3

9.73e-062109216081808
Pubmed

Differential pathways of angiotensin II-induced extracellularly regulated kinase 1/2 phosphorylation in specific cell types: role of heparin-binding epidermal growth factor.

MAPK1 MAPK3

9.73e-062109215143154
Pubmed

Ajoene-induced cell death in human promyeloleukemic cells does not require JNK but is amplified by the inhibition of ERK.

MAPK1 MAPK3

9.73e-062109212555071
Pubmed

ERK1/2 is related to oestrogen receptor and predicts outcome in hormone-treated breast cancer.

MAPK1 MAPK3

9.73e-062109225085753
Pubmed

ERK1 and ERK2 kinases activate hydroxyurea-induced S-phase checkpoint in MCF7 cells by mediating ATR activation.

MAPK1 MAPK3

9.73e-062109220840867
Pubmed

ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice.

MAPK1 MAPK3

9.73e-062109219286961
Pubmed

Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling.

MAPK1 MAPK3

9.73e-062109219147767
Pubmed

Posttranslational regulation of CALHM1/3 channel: N-linked glycosylation and S-palmitoylation.

CALHM1 CALHM3

9.73e-062109233788965
Pubmed

Anaplasma phagocytophilum AptA modulates Erk1/2 signalling.

MAPK1 MAPK3

9.73e-062109220716207
Pubmed

Leukaemia inhibitory factor mediated proliferation of HTR-8/SVneo trophoblast cells is dependent on activation of extracellular signal-regulated kinase 1/2.

MAPK1 MAPK3

9.73e-062109221635820
Pubmed

Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo.

MAPK1 MAPK3

9.73e-062109217709754
Pubmed

Cholesterol affects gene expression of the Jun family in colon carcinoma cells using different signaling pathways.

MAPK1 MAPK3

9.73e-062109223643895
Pubmed

A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses.

MAPK1 MAPK3

9.73e-062109228986121
Pubmed

Calcitonin targets extracellular signal-regulated kinase signaling pathway in human cancers.

MAPK1 MAPK3

9.73e-062109218055485
Pubmed

Differential functions of ERK1 and ERK2 in lung metastasis processes in triple-negative breast cancer.

MAPK1 MAPK3

9.73e-062109232444778
Pubmed

Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cells.

MAPK1 MAPK3

9.73e-062109215322023
Pubmed

MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo.

MAPK1 MAPK3

9.73e-062109215096454
Pubmed

Both ERK1 and ERK2 are required for enterovirus 71 (EV71) efficient replication.

MAPK1 MAPK3

9.73e-062109225803100
Pubmed

Phosphate-induced apoptosis of hypertrophic chondrocytes is associated with a decrease in mitochondrial membrane potential and is dependent upon Erk1/2 phosphorylation.

MAPK1 MAPK3

9.73e-062109220404333
Pubmed

Desialylation of glycoconjugates on the surface of monocytes activates the extracellular signal-related kinases ERK 1/2 and results in enhanced production of specific cytokines.

MAPK1 MAPK3

9.73e-062109214634064
Pubmed

Deletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neurogenesis in Erk2-deficient mice.

MAPK1 MAPK3

9.73e-062109221248139
Pubmed

FasL expression in cardiomyocytes activates the ERK1/2 pathway, leading to dilated cardiomyopathy and advanced heart failure.

MAPK1 MAPK3

9.73e-062109226566650
Pubmed

[Effect of ERK1/2 signal pathway on the proliferation of lung fibroblast activated by SiO₂].

MAPK1 MAPK3

9.73e-062109221126445
Pubmed

Irradiation-induced G2/M checkpoint response requires ERK1/2 activation.

MAPK1 MAPK3

9.73e-062109217297454
Pubmed

Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways.

MAPK1 MAPK3

9.73e-062109215542825
Pubmed

Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2.

MAPK1 MAPK3

9.73e-062109215721302
Pubmed

Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium.

MAPK1 MAPK3

9.73e-062109226046303
Pubmed

Vasoconstrictor effects of insulin in skeletal muscle arterioles are mediated by ERK1/2 activation in endothelium.

MAPK1 MAPK3

9.73e-062109215059773
Pubmed

Allosteric activation of the extracellular Ca2+-sensing receptor by L-amino acids enhances ERK1/2 phosphorylation.

MAPK1 MAPK3

9.73e-062109217212589
Pubmed

Porcine reproductive and respiratory syndrome virus replication is suppressed by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway.

MAPK1 MAPK3

9.73e-062109220540975
InteractionUBE4B interactions

UBE4B AMZ1 STAM ITPR1 PTPA MAPK1 MAPK3

7.16e-061401027int:UBE4B
InteractionTEX19 interactions

ZBTB2 ZNF490 SALL1 ZNF648 ZBTB10

7.82e-06541025int:TEX19
InteractionCBX5 interactions

STAM2 ZBTB2 ZNF584 MBD1 ZNF280C REST IFI16 ZNF462 SETDB1 ZMYM3

1.32e-0535610210int:CBX5
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF536 ZBTB2 ZNF584 ZFP30 ZNF275 ZNF692 ZNF490 ZNF462 ZNF800 ZSCAN20 SALL1 ZNF780A ZNF648 ZBTB10 ZNF81 ZFP62 ZNF574

4.62e-08718871728
GeneFamilyProtein phosphatase 6 regulatory subunits

ANKRD44 ANKRD28 ANKRD52

2.13e-066873699
GeneFamilyMitogen-activated protein kinases

MAPK15 MAPK1 MAPK3

2.97e-0513873651
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR1 ITPR2

6.85e-053872297
GeneFamilyESCRT-0

STAM2 STAM

6.85e-0538721115
GeneFamilyProtein phosphatase 2 modulatory subunits

PTPA LCMT1

2.27e-0458721265
GeneFamilyZinc fingers MYM-type

ZMYM1 ZMYM3

3.39e-04687286
GeneFamilyActin related protein 2/3 complex

ARPC1A ARPC1B

8.06e-04987239
GeneFamilyZinc fingers CXXC-type|Methyl-CpG binding domain containing

MBD1 SETDB1

1.22e-03118721025
GeneFamilyAnkyrin repeat domain containing

ANKRD44 ANKRD17 ANKRD28 ANKFN1 ANKRD52

6.26e-03242875403
ToppCellfacs-GAT-Fat-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF692 ITPR2 ANKRD44 SALL1 GIMAP8 DNAH8

4.77e-061761096acd05ca8952710feedbfe377b1330f3c2406d044
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AMPD1 CHODL EML6 ANKRD44 DNAH8 LY86

9.09e-0619710960f489d26e4013d1b5a90559856ed2de32a0bb772
ToppCellsevere|World / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

OAS3 IFI16 ARRB2 GYG1 BRI3 GCA

9.63e-061991096c24aacef7405700bc5d0b736a38feea12b7f17c8
ToppCell3'-Parenchyma_lung-Immune_Myeloid|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARPC1B ARRB2 BRI3 GCA UPP1 LY86

9.63e-061991096e29cd315662a8a33470964d102a61f5d3f6797e9
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Adora2a_(Striatum,_iSPNs)--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CALHM3 CALHM4 ZNF648 SCNN1G

1.34e-05591094a8c9a99501dc244471362915dd847ab2c6e164bf
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Adora2a_(Striatum,_iSPNs)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CALHM3 CALHM4 ZNF648 SCNN1G

1.34e-05591094469e47aa60bf7072e80db15e51da4c103b2a21ff
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Adora2a_(Striatum,_iSPNs)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CALHM3 CALHM4 ZNF648 SCNN1G

1.34e-055910944f9f20aa4d5ad91c01ef7e9d60b59b5bade6a399
ToppCelldroplet-Bladder-nan-3m-Hematologic-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDHGA10 OAS3 F10 LY86 VAV1

3.51e-051511095a7b1a60d68f0ed17022fe4c97af64f9f08d39fa3
ToppCellNS-critical-d_16-33-Myeloid-Monocyte-derived_Macrophage|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

OAS3 NRN1 RFPL4A ZSCAN20 SLC27A3

3.74e-051531095859de35b24c5d7d73be1c213b90b43362ee2e0eb
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

AMPD1 STAM GEM METTL8 DNAH8

3.86e-0515410959200e2f1783e54cbc5dfc3b485b57c761af74a46
ToppCell368C-Lymphocytic-NK_cells-NK_cell_A|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CHODL ZFP30 F10 CD160 SLC27A3

4.23e-051571095542944030cd9b3f3559e64f9f6598694d74003c0
ToppCelldroplet-Limb_Muscle-nan-18m-Myeloid-macrophage|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OAS3 F10 ARRB2 LY86 VAV1

5.21e-0516410958d089844896e84935eab705ebe54f125c4b6d9ca
ToppCelldroplet-Limb_Muscle-nan-18m-Myeloid|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OAS3 F10 ARRB2 LY86 VAV1

5.21e-05164109517fb1421476ba44999b1165f2576514f74c1f882
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDHGA10 EML6 ITGA9 WDR3 ZSCAN20

5.36e-0516510951703d3eb644b3c743ad3c5532b1d29ea010c79c8
ToppCellE18.5-Immune-Immune_Myeloid|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARPC1B F10 ARRB2 LY86 VAV1

5.36e-05165109557de10d9237e56fafaa58995792f998fecc77e7a
ToppCellfacs-Kidney-nan-3m-Myeloid-macrophage|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA1 ITGA9 ARRB2 LY86 VAV1

5.68e-051671095991a93e1075d562b7391f0689b2f62c1351d48d1
ToppCellfacs-Kidney-nan-3m-Myeloid|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA1 ITGA9 ARRB2 LY86 VAV1

5.68e-051671095f22d1471c785b30d096ec5cdc68974e850ed7de0
ToppCelldroplet-Limb_Muscle-nan-18m-Myeloid-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OAS3 F10 ARRB2 LY86 VAV1

5.68e-0516710957f9eedf68a800159c5642e04dd9569ae58109bd5
ToppCellfacs-Kidney-nan-3m-Myeloid-macrophage|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA1 ITGA9 ARRB2 LY86 VAV1

5.68e-051671095934905aeaafbc215ec8f6a7903498b0e258b9220
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MBD1 F10 ARRB2 ANKRD52 VAV1

5.84e-051681095c3d2d573f21350a4a674faff30b06ff644d00ac3
ToppCellPND03-Immune|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARPC1B F10 ARRB2 LY86 VAV1

6.71e-0517310958543304ae72f781da311deca05871098eabc4a19
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF536 NRN1 SALL1 GIMAP8 DNAH8

7.08e-051751095c36b4526970db9ccfbe2c70b00961fab9f13b133
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF536 NRN1 SALL1 GIMAP8 DNAH8

7.08e-051751095c1e082538f31b5c98ac63f71dcca4a1211a14708
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF536 NRN1 SALL1 GIMAP8 DNAH8

7.08e-0517510952f9b5bdf8a62e8e99d1c4f677a8e5525bfd3b4ce
ToppCellfacs-Thymus-Epithelium-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRP54 GEM NOD1 LY86 TANGO6

7.47e-051771095c2b8a3a149d70f77612759dea34df9e43953c566
ToppCellfacs-Thymus-Epithelium-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRP54 GEM NOD1 LY86 TANGO6

7.47e-051771095384f841aa7b2d05815af7885e481f5affc55d897
ToppCellfacs-Thymus-Epithelium-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRP54 GEM NOD1 LY86 TANGO6

7.47e-0517710950e9e44119653abfd270e602e5e477a15e774638f
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD160 ZNF462 SUSD2 UPP1 SLC27A3

7.68e-051781095408e41c853f608965cef9111fb87fdc311cdc7a8
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

STAM GEM SUSD2 ZNF81 KLHL17

8.30e-0518110959275531e896e118cee043ed94fd31a0070d9581c
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

STAM GEM SUSD2 ZNF81 KLHL17

8.52e-05182109521744c9c792e57d5d41b25986f419b2358c7057b
ToppCelldroplet-Marrow-nan-18m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARPC1B ARRB2 GYG1 GCA MAPK3

9.93e-051881095fa7a612b0a2b35de5f76a0408168dabe5db00773
ToppCell3'-Adult-Distal_Rectal-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRN1 IFI16 ITPR1 GIMAP8 FGF2

1.02e-0418910950c612ff5f882f2d8ec744a347780bbbe7cc471bd
ToppCell3'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRN1 IFI16 ITPR1 GIMAP8 FGF2

1.02e-041891095bc8949bd4f425ed36e2c05e653c94cb1593c5bee
ToppCellILEUM-non-inflamed-(1)_T_cell-(1)_Tregs|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

STAM GEM ARPC1B METTL8 DNAH8

1.04e-041901095f69a4733b5d1542ab4d0eb44856f2c5c34c18b9e
ToppCellfacs-Brain_Myeloid|facs / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA1 ARRB2 SALL1 LY86 VAV1

1.07e-041911095bf1135b382a3bf8cddc19538bc38361ef1fc2de1
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IFI16 ARRB2 GIMAP8 LY86 VAV1

1.18e-04195109542bfdff88da1d07828c0ad65d412fb1752f0cee4
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4/8-lo|GI_small-bowel / Manually curated celltypes from each tissue

AMZ1 STAM GEM CD160 MAPK1

1.21e-041961095a54ec174461944229c98a0b48b4822a556191ccb
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Trm_Tgd|GI_small-bowel / Manually curated celltypes from each tissue

AMZ1 STAM GEM CD160 MAPK1

1.21e-04196109584cab9390794fe50203834b745722bf11c208ebd
ToppCellfacs-Brain_Myeloid-Cortex_-18m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA1 ARRB2 SALL1 BRI3 VAV1

1.24e-041971095e73ca8c8f42cbcc56eaa5fe3d69abd1ce7b7bbca
ToppCellfacs-Brain_Myeloid-Cortex_|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA1 ARRB2 SALL1 BRI3 VAV1

1.24e-04197109581379fe6bd14a1ba26f4a159497262adcb600b18
ToppCellfacs-Brain_Myeloid-Cortex_-18m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA1 ARRB2 SALL1 BRI3 VAV1

1.24e-041971095271c75f491d03bd248c7ec037ef02e39456f3ac0
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IFI16 ANKRD44 ARRB2 LY86 VAV1

1.24e-041971095d95565652ca318a2298d6918d54ba6367e9560f4
ToppCellfacs-Brain_Myeloid-Cortex_-18m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA1 ARRB2 SALL1 BRI3 VAV1

1.24e-0419710959db329c6fea532dd1afb624f4c29c92407f45568
ToppCellfacs-Brain_Myeloid-Cortex_-18m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA1 ARRB2 SALL1 BRI3 VAV1

1.24e-041971095173c0c8de4e69882a9f91189deeb4a651fefe551
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-F_2|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ZNF280C STAM ARPC1B METTL8 DNAH8

1.24e-04197109554fb7197db3c0dc87a1114e1ab1d2bfafd564b35
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IFI16 ARPC1B ARRB2 GCA LY86

1.27e-0419810958a29a5a1c3b4dd7af97db303091c90ad379504d6
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

STAM GEM ARPC1B METTL8 DNAH8

1.27e-04198109503423d6c614440b9c738f75ac3f5a6941719a279
ToppCellFetal_29-31_weeks-Immune|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ITPR2 ANKRD44 ARRB2 LY86 VAV1

1.27e-0419810955dff131356b8c22743bd27b2b21f86ee6e4a0a0d
ToppCellSmart-seq2-thymus_(Smart-seq2)-myeloid|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ARPC1B ARRB2 BRI3 GCA UPP1

1.27e-0419810952e470249edc7cf85bed550795ff84cbef22895c0
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IFI16 ANKRD44 ARRB2 LY86 VAV1

1.30e-04199109504adf46975aa4194ea40c7480f8a517def5d929c
ToppCell3'_v3-blood-Myeloid_Monocytic|blood / Manually curated celltypes from each tissue

ARPC1B ARRB2 BRI3 GCA LY86

1.30e-041991095bf3a5085a5ae50f2ef745dce0a4ca8833b9438fd
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARRB2 SALL1 GIMAP8 LY86 VAV1

1.30e-041991095744b63fba33b176ab7dde11646ccb313665505f7
ToppCellcellseq-Immune-Immune_Myeloid|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARPC1B ARRB2 GCA UPP1 LY86

1.30e-041991095f151a209bfcdb3d17b6bdf995415b63c2ee07246
ToppCell367C-Myeloid|367C / Donor, Lineage, Cell class and subclass (all cells)

ARRB2 BRI3 GCA UPP1 LY86

1.30e-04199109589f42cbd9231adec86e704ef460b2d8fd1afc00a
ToppCell3'_v3-blood-Myeloid_Monocytic-Classical_monocytes|blood / Manually curated celltypes from each tissue

ARPC1B ARRB2 BRI3 GCA LY86

1.30e-04199109595b27f4bf1300f885b95c1a70a54252274dc8f51
ToppCellcellseq-Immune|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARPC1B ARRB2 GCA UPP1 LY86

1.30e-041991095d564386a684e542b42a2f4d3b2053cef72a87700
ToppCell5'-Parenchyma_lung-Immune_Myeloid|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARPC1B ARRB2 GCA UPP1 LY86

1.33e-04200109537a091925b214a0befea59b711ab92809a7b93c8
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-dn_T|ICU-SEP / Disease, condition lineage and cell class

SETDB1 C2CD3 ZNF780A ANKRD28 ZNF81

1.33e-0420010959ee3e18dc429b9c472e3e366d9bfdbb150daa369
ToppCellControl-Control-Myeloid-cDC2|Control / Disease, condition lineage and cell class

IFI16 GEM ARPC1B GCA LY86

1.33e-042001095fd769cb21cac2364212524ef4786e77a4cc7faa7
ToppCell10x3'2.3-week_14-16-Myeloid_monocytic-monocyte-CD14_monocyte|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ARPC1B ARRB2 BRI3 GCA LY86

1.33e-042001095527b7388700096686293f3f6b112269e87908dfa
Drugdimethyl selenone

MAPK15 FGF2 MAPK1 MAPK3

6.87e-0961074CID000176413
Drug3,5-diiodothyropropionic acid

FGF2 MAPK1 MAPK3

1.01e-0731073ctd:C082182
Drugxestospongin C

ITPR1 ITPR2 MAPK1 MAPK3

2.22e-07121074ctd:C511704
Drugpamoic acid

ARRB2 MAPK1 MAPK3

4.02e-0741073ctd:C004368
DrugJTE 907

ARRB2 MAPK1 MAPK3

4.02e-0741073ctd:C422645
DrugPD 166285

FGF2 MAPK1 MAPK3

4.02e-0741073ctd:C109647
DrugPD 198306

ARRB2 MAPK1 MAPK3

1.00e-0651073ctd:C475178
DrugBAY 60-6583

FGF2 MAPK1 MAPK3

1.00e-0651073ctd:C518875
DrugNiclosamide [50-65-7]; Up 200; 12.2uM; PC3; HT_HG-U133A

IFI16 CBS GEM ITPR2 ZBTB10 FGF2 UPP1 NR1H4

1.30e-0616810784018_UP
DrugDobutamine

ARRB2 SCNN1G FGF2 MAPK1 MAPK3 NR1H4

1.83e-06781076ctd:D004280
Drugdipropionamide

MAPK15 MAPK1 MAPK3

2.00e-0661073CID000138646
Drugethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate

FGF2 MAPK1 MAPK3

2.00e-0661073ctd:C560274
DrugN-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide

ARRB2 MAPK1 MAPK3

2.00e-0661073ctd:C553580
Druglercanidipine

MAPK1 MAPK3 NR1H4

3.48e-0671073ctd:C060343
Drugthunberginol B

MAPK15 MAPK1 MAPK3

5.56e-0681073CID005473310
DrugDEAC

RPS6KA1 ITGA9 MAPK15 MAPK1 MAPK3

6.02e-06551075CID000007277
Drugarabinosyladenine

AMPD1 OAS3 CBS NT5DC1 F10 ITPR1 PTPA MAPK15 SCNN1G BRI3 UPP1 MAPK1 HARS1 MAPK3

1.34e-0576210714CID000000191
DrugGYY 4137

CBS MAPK1 MAPK3

1.62e-05111073ctd:C529376
DrugBI D1870

RPS6KA1 MAPK1 MAPK3

1.62e-05111073ctd:C516541
Drug14,15-epoxy-5,8,11-eicosatrienoic acid

FGF2 MAPK1 MAPK3

2.15e-05121073ctd:C046782
DrugN-acetyl glycine cysteine amide

MAPK1 MAPK3

2.19e-0521072ctd:C510898
DrugN-acetyl-Cys-Gly-Pro-Cys-amide

MAPK1 MAPK3

2.19e-0521072ctd:C510899
Drugcysteinyl-leukotriene

MAPK1 MAPK3

2.19e-0521072ctd:C112381
DrugNP00111

MAPK1 MAPK3

2.19e-0521072ctd:C530042
Drugsubstance P (6-11), Tyr(6)-D-Phe(7)-D-His(9)-

MAPK1 MAPK3

2.19e-0521072ctd:C496429
Drug7-methyljuglone

MAPK1 MAPK3

2.19e-0521072ctd:C517013
Drugsodium tetrasulfide

MAPK1 MAPK3

2.19e-0521072ctd:C519323
Drug2,2',4,4',5,5'-hexabrominated diphenyl ether

MAPK1 MAPK3

2.19e-0521072ctd:C478854
DrugCGP 56999A

MAPK1 MAPK3

2.19e-0521072ctd:C102659
DrugAG 127

MAPK1 MAPK3

2.19e-0521072ctd:C069028
DrugNF023

MAPK1 MAPK3

2.19e-0521072ctd:C105374
Drugtyrphostin 51

MAPK1 MAPK3

2.19e-0521072ctd:C118515
DrugL 759656

MAPK1 MAPK3

2.19e-0521072ctd:C118949
DrugN-(4-aminobutyl)-1-naphthalenesulfonamide

MAPK15 MAPK1 MAPK3

2.79e-05131073CID000005679
DrugGuanosine

UPP1 MAPK1 MAPK3

2.79e-05131073ctd:D006151
DrugSB202474

MAPK15 MAPK1 MAPK3

3.54e-05141073CID000005162
Drug2-amino-4-phosphonobutyric acid

ARRB2 MAPK1 MAPK3

3.54e-05141073ctd:C012729
DrugNoscapine [128-62-1]; Down 200; 9.6uM; HL60; HG-U133A

STAM2 UBE4B IFI16 NOD1 MAPK3 ZMYM3 SLC27A3

4.37e-0519910771753_DN
DrugEnkephalin, Ala(2)-MePhe(4)-Gly(5)-

ARRB2 MAPK1 MAPK3

4.41e-05151073ctd:D020875
DrugSCH772984

FGF2 MAPK1 MAPK3

4.41e-05151073ctd:C587178
Drugpicropodophyllin

MAPK1 MAPK3 NR1H4

4.41e-05151073ctd:C415032
Drugsodium ferulate

MC5R MAPK15 GYG1 MAPK1 MAPK3

6.00e-05881075CID000000709
Drugwithaferin A

MAPK15 UPP1 MAPK1 MAPK3

6.46e-05461074CID000265237
DrugRG-13577

FGF2 MAPK1 MAPK3

6.54e-05171073CID003081306
DrugPQ 401

MAPK1 MAPK3

6.54e-0531072ctd:C569479
Drugcassine

MAPK1 MAPK3

6.54e-0531072ctd:C426663
Drugmanganese(III) acetate dihydrate

MAPK1 MAPK3

6.54e-0531072ctd:C521134
DrugNipaam-ntbam copolymer

MAPK1 MAPK3

6.54e-0531072CID003080965
Drugdelta(4)-tibolone

MAPK1 MAPK3

6.54e-0531072ctd:C485706
DrugtPA stop

MAPK1 MAPK3

6.54e-0531072ctd:C115645
DrugLBT 613

MAPK1 MAPK3

6.54e-0531072ctd:C514877
DrugAAL 881

MAPK1 MAPK3

6.54e-0531072ctd:C514876
DrugNGB 2904

MAPK1 MAPK3

6.54e-0531072ctd:C116818
Drug19-epi-okadaic acid

MAPK1 MAPK3

6.54e-0531072ctd:C522300
Drugalpha-methyl-4-carboxyphenylglycine

MAPK1 MAPK3

6.54e-0531072ctd:C079694
Drug5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole

MAPK1 MAPK3

6.54e-0531072ctd:C534240
DrugYM-254890

MAPK1 MAPK3

6.54e-0531072ctd:C475455
Drugpoly(N-isopropylacrylamide-N-tert-butylacrylamide)copolymer

MAPK1 MAPK3

6.54e-0531072ctd:C079805
Drugcapsanthin

MAPK1 MAPK3

6.54e-0531072ctd:C006889
Drughispidulin

MAPK1 MAPK3

6.54e-0531072ctd:C055957
Drugbromoxynil octanoate

MAPK1 MAPK3

6.54e-0531072ctd:C028382
DrugHFMC

FGF2 MAPK1

6.54e-0531072CID000175887
DrugPyridazines

MAPK1 MAPK3

6.54e-0531072ctd:D011724
DrugSB 258585

MAPK1 MAPK3

6.54e-0531072ctd:C418570
Drugconnective tissue-activating peptide

MAPK1 MAPK3

6.54e-0531072ctd:C009862
Drugspectaline

MAPK1 MAPK3

6.54e-0531072ctd:C480880
Drugp38alpha inhibitor CMPD1

MAPK1 MAPK3

6.54e-0531072ctd:C492719
DrugOR486

MAPK1 MAPK3

6.54e-0531072ctd:C057726
DrugGW2974

MAPK1 MAPK3

6.54e-0531072ctd:C506645
Drugkaempferol-7-methyl ether

MAPK1 MAPK3

6.54e-0531072ctd:C541117
Drugwogonoside

MAPK1 MAPK3

6.54e-0531072ctd:C473995
DrugGinkgolides

MAPK1 MAPK3

6.54e-0531072ctd:D046934
DrugML 204

MAPK1 MAPK3

6.54e-0531072ctd:C567966
Drughwanggunchungyitang

MAPK1 MAPK3

6.54e-0531072ctd:C539018
DrugBPC96 peptide

MAPK1 MAPK3

6.54e-0531072ctd:C555919
DrugN,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea

MAPK1 MAPK3

6.54e-0531072ctd:C541384
DrugSRT1720

FGF2 MAPK1 MAPK3 NR1H4

7.04e-05471074ctd:C525422
DrugIloprost

FGF2 MAPK1 MAPK3

9.26e-05191073ctd:D016285
DrugAlprenolol

ARRB2 MAPK1 MAPK3

9.26e-05191073ctd:D000526
Drugfenvalerate

ITPR1 MAPK1 MAPK3 HSD17B1 NR1H4

9.54e-05971075ctd:C017690
Drug2,2',3,5',6-pentachlorobiphenyl

REST MAPK1 MAPK3

1.09e-04201073ctd:C032904
DrugSR 57746A

PTPA MAPK1 MAPK3

1.09e-04201073CID000128918
DrugSU 6656

RPS6KA1 MAPK1 MAPK3

1.26e-04211073ctd:C416927
Drugisosalipurposide

MAPK1 MAPK3

1.30e-0441072ctd:C027321
Drugdiacetylbis(4-methylthiosemicarbazonato)copper(II)

MAPK1 MAPK3

1.30e-0441072ctd:C570445
Drug2-(2-oxo-2-((3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy)aminoethyl)phosphonic acid, (2,2-dimethyl-1-oxopropoxy)methyl ester sodium

MAPK1 MAPK3

1.30e-0441072ctd:C436083
Drug2,3,4,2',3',4'-hexachlorobiphenyl

MAPK1 MAPK3

1.30e-0441072ctd:C014218
Drug3-(phenylsulfonyl)-4-(2-(4-(2-(3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoyl)piperazin-1-yl)ethoxy)-1,2,5-oxadiazole-2-oxide

MAPK1 MAPK3

1.30e-0441072ctd:C559860
DrugPurvalanol

MAPK1 MAPK3

1.30e-0441072DB02733
DrugDmt-NMe-Ala-Aba-Gly-NH2

MAPK1 MAPK3

1.30e-0441072ctd:C569763
DrugO(2)-(2,4-dinitrophenyl) 1-(4-(N,N-diethylcarboxamido)piperazin-1-yl)diazen-1-ium 1,2-diolate

MAPK1 MAPK3

1.30e-0441072ctd:C495194
Drug3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine

MAPK1 MAPK3

1.30e-0441072ctd:C423582
Drug4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate)

MAPK1 MAPK3

1.30e-0441072ctd:C110258
Drugphenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide

MAPK1 MAPK3

1.30e-0441072ctd:C049352
Drug2,5,3'-trichlorobiphenyl

MAPK1 MAPK3

1.30e-0441072ctd:C091160
Drugbovine serum albumin-corticosterone conjugate

MAPK1 MAPK3

1.30e-0441072ctd:C439264
Drugcorticosterone-21-hemisuccinate

MAPK1 MAPK3

1.30e-0441072ctd:C067957
Drugado-trastuzumab emtansine

MAPK1 MAPK3

1.30e-0441072ctd:C550911
Drugneurotropin

MAPK1 MAPK3

1.30e-0441072ctd:C010491
DrugN-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide

MAPK1 MAPK3

1.30e-0441072ctd:C481448
DiseaseAnoxic Encephalopathy

ITPR1 ITPR2

1.18e-0521022C0003132
DiseaseBrain Hypoxia

ITPR1 ITPR2

1.18e-0521022C1527348
DiseaseAnoxia of brain

ITPR1 ITPR2

1.18e-0521022C0995195
DiseaseHypoxic Brain Damage

ITPR1 ITPR2

1.18e-0521022C1140716
Diseaseschizophrenia (is_marker_for)

ARPC1A ARPC1B SETDB1 MAPK3

1.64e-05441024DOID:5419 (is_marker_for)
DiseaseAstrocytosis

FGF2 MAPK1 MAPK3

2.63e-05171023C3887640
DiseaseGliosis

FGF2 MAPK1 MAPK3

2.63e-05171023C0017639
Diseasenon-alcoholic fatty liver disease, type 2 diabetes mellitus

AMZ1 ABHD10 SLC9C2 ARPC1B DNAH8

4.10e-051101025EFO_0003095, MONDO_0005148
DiseaseCEROID LIPOFUSCINOSIS, NEURONAL, 6

MAPK1 MAPK3

1.76e-0461022C1866282
DiseaseStreptococcal pneumonia

MAPK1 MAPK3

1.76e-0461022C0155862
Diseaseendometrial adenocarcinoma (is_implicated_in)

MAPK1 MAPK3

2.46e-0471022DOID:2870 (is_implicated_in)
Diseaseureteral obstruction (implicated_via_orthology)

MAPK1 MAPK3

4.19e-0491022DOID:5199 (implicated_via_orthology)
Diseaselymphocyte count

UBE4B PCDHGA10 RPS6KA1 AMZ1 ARPC1A EML6 REST ITPR1 ITPR2 ZNF800 ARRB2 GIMAP8 FGF2 VAV1

5.12e-04146410214EFO_0004587
DiseaseMuscle Weakness

AMPD1 GYG1

5.23e-04101022C0151786
Diseasehyperhomocysteinemia (implicated_via_orthology)

CBS F10

6.38e-04111022DOID:9279 (implicated_via_orthology)
Diseaseendometrial adenocarcinoma (is_marker_for)

MAPK1 MAPK3

6.38e-04111022DOID:2870 (is_marker_for)
DiseaseCocaine-Related Disorders

FGF2 MAPK1 MAPK3 DNAH8

7.40e-041171024C0236736
DiseaseTrigeminal Neuralgia

MAPK1 MAPK3

7.64e-04121022C0040997
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR1 ITPR2

7.64e-04121022DOID:1441 (implicated_via_orthology)
DiseaseSecondary Trigeminal Neuralgia

MAPK1 MAPK3

7.64e-04121022C0393787
DiseaseTrigeminal Neuralgia, Idiopathic

MAPK1 MAPK3

7.64e-04121022C0393786
DiseaseCocaine Abuse

FGF2 MAPK1 MAPK3 DNAH8

1.00e-031271024C0009171
Diseasegastric ulcer (implicated_via_orthology)

MAPK1 MAPK3

1.05e-03141022DOID:10808 (implicated_via_orthology)
Diseasepolycystic kidney disease (implicated_via_orthology)

STAM2 STAM

1.05e-03141022DOID:0080322 (implicated_via_orthology)
DiseaseFEV change measurement, response to bronchodilator

MBD1 MC5R UBR3

1.08e-03581023EFO_0005921, GO_0097366
DiseaseBipolar Disorder

ITGA9 CBS ITPR1 PTPA ARRB2 MAPK1 DNAH8

1.36e-034771027C0005586
Diseasesuccinylcarnitine measurement

ZNF536 PTPA

1.38e-03161022EFO_0020020
DiseaseCocaine Dependence

FGF2 MAPK1 MAPK3 DNAH8

1.40e-031391024C0600427
DiseaseMAJOR AFFECTIVE DISORDER 2

ITGA9 PTPA

1.56e-03171022C1839839
DiseaseFetal Alcohol Syndrome

RPS6KA1 REST

1.56e-03171022C0015923
DiseaseHypertrophy

MAPK1 MAPK3

1.75e-03181022C0020564
Diseaseprostate adenocarcinoma (is_implicated_in)

FGF2 MAPK1

2.16e-03201022DOID:2526 (is_implicated_in)
DiseaseNerve Degeneration

FGF2 MAPK1 MAPK3

3.02e-03831023C0027746
DiseaseC-reactive protein measurement

ZNF536 UBE4B HYKK RPS6KA1 IFI16 NT5DC1 ITPR1 ANKRD44 SALL1 NR1H4 SLC27A3

3.03e-03120610211EFO_0004458
DiseaseSepticemia

MAPK1 MAPK3

3.11e-03241022C0036690
DiseaseAnhedonia

SETDB1 MAPK1

3.11e-03241022C0178417
DiseaseSepsis

MAPK1 MAPK3

3.11e-03241022C0243026
DiseaseSevere Sepsis

MAPK1 MAPK3

3.11e-03241022C1719672
DiseaseHead Neoplasms

MAPK1 MAPK3

3.11e-03241022C0018675
DiseaseUpper Aerodigestive Tract Neoplasms

MAPK1 MAPK3

3.11e-03241022C0887900
DiseasePyemia

MAPK1 MAPK3

3.11e-03241022C0034189
DiseaseCancer of Head

MAPK1 MAPK3

3.11e-03241022C0751177
Diseasereticulocyte count

RPS6KA1 ZNF280C EML6 REST ARPC1B F10 ZNF800 NOD1 GIMAP8 LY86

3.34e-03104510210EFO_0007986
DiseaseNeck Neoplasms

MAPK1 MAPK3

3.37e-03251022C0027533
DiseaseCancer of Neck

MAPK1 MAPK3

3.37e-03251022C0746787

Protein segments in the cluster

PeptideGeneStartEntry
LCRVAFCFLAVGLVD

TRBV28

6

A0A5B6
LCSCTEAFFLGLRVK

AMZ1

116

Q400G9
CRVGVLEDCFTFLGI

BRI3

81

O95415
FVVFLCKDRSGDCSP

CD160

56

O95971
LLAAGSCDFKCRIFS

ARPC1B

156

O15143
LALLDGKCFVCAFSS

CALHM3

116

Q86XJ0
GRIFFDDYVACCVKL

GCA

171

P28676
DCCRKLLSSGFDIDT

ANKRD28

386

O15084
AVTLLDGKCFLCAFC

CALHM1

116

Q8IU99
EDFEIVCKGLYRALC

AMPD1

131

P23109
ACCGGFLEVADFLIK

ANKRD17

541

O75179
LHLAVLFGFSDCCRK

ANKRD52

376

Q8NB46
LFGFSDCCRKLLSSG

ANKRD52

381

Q8NB46
CGVDFEIRAFCAKSL

ARRB2

141

P32121
LLAAGSCDFKCRVFS

ARPC1A

156

Q92747
GRACAVVFDCKFIET

GEM

206

P55040
TCFICGLERDKFDNK

ITPR2

2561

Q14571
ALTCEGCKGFFRRSI

NR1H4

151

Q96RI1
ARCTFRNFLGKEACE

CAPN15

51

O75808
RNFLGKEACEVCGFT

CAPN15

56

O75808
CDLKICDFGLARVAD

MAPK1

161

P28482
LAVKAAKGDFVCIFC

REST

1051

Q13127
FFCEILSVLKLACAD

OR2A14

176

Q96R47
FCCKGLALDLEDGNF

NT5DC1

61

Q5TFE4
EACRALVFGGCVEKS

NEIL1

16

Q96FI4
ICEAALPKFSFCGRR

LY86

101

O95711
LRLCLKRFTCEDAGA

IL17REL

141

Q6ZVW7
KTTCFICGLERDKFD

ITPR1

2616

Q14643
DANCTVKLCDFGLAR

MAPK15

146

Q8TD08
ACDLTLFDFKQGILC

MBD1

56

Q9UIS9
SKDCSGLVLLCLFFG

PCDHGA10

11

Q9Y5H3
GLCIFFVRCRNDVAI

DNAH8

16

Q96JB1
LSYKFLGERDCAAPC

FZD2

211

Q14332
CFKESDRLCLQDLLF

NOD1

241

Q9Y239
CDAVFKGFSDCLLKL

NRN1

31

Q9NPD7
TTCDLKICDFGLARI

MAPK3

176

P27361
DCCRKLLSSGFEIDT

ANKRD44

386

Q8N8A2
GLLCRFCSVVSQKDD

RFPL4A

46

A6NLU0
FFCEILAVLKLACAD

OR2A7

176

Q96R45
FVFAGLADTECCLLA

OR5C1

106

Q8NGR4
RCVEDAKIFGIQSFC

GRPEL2

96

Q8TAA5
FFCEILAVLKLACAD

OR2A4

176

O95047
CELLESDFLKCSVGF

ITGA9

696

Q13797
EKGALFLLVCSRFCQ

HYKK

301

A2RU49
FSCGFCRKEDVSGAI

GYG1

286

P46976
GVRDACCKFLLSQLD

KLHL17

176

Q6TDP4
CSGEACFLAELLEFA

C2CD3

1276

Q4AC94
YCASKFALEGLCESL

HSD17B1

156

P14061
RCLSCCEKGDTFFVL

GIMAP8

516

Q8ND71
CLELDDAIRSCKGAF

C20orf85

111

Q9H1P6
DAIRSCKGAFARELC

C20orf85

116

Q9H1P6
LKCELLAKCEFFNAG

CBS

101

P35520
ECKLACLRFFSITGR

CALHM4

96

Q5JW98
CEEGDKLQLFCFRLR

IFI16

356

Q16666
FKEIICCRGFRIACS

MC5R

306

P33032
DGRLLASKCVTDECF

FGF2

221

P09038
CALDFSADGKCLVSV

EML6

776

Q6ZMW3
TCLEGFEGKNCELFT

F10

111

P00742
CELFTRKLCSLDNGD

F10

121

P00742
LLVTCFFDGVSCDAR

SCNN1G

256

P51170
VCDPACRRFKLTDFG

SBK2

191

P0C263
GRCCAEFFELSDLLL

SALL1

46

Q9NSC2
CRFCAKVFGSDSALQ

SALL1

451

Q9NSC2
FAICGVSDSKFRTIC

HARS1

221

P12081
LYCCDFASGAVELVK

METTL8

226

Q9H825
FFCEILSVLRLACAD

OR2A1;

176

Q8NGT9
GGCDSELVIFLDCFK

OAS3

71

Q9Y6K5
GLSKCEVSCSAFIRF

FBXL21P

371

Q9UKT6
FCLCGRIYKDIFLDS

MAP3K15

361

Q6ZN16
FLRCCGCVFSERALK

RTF2

136

Q9BY42
KAFIRCVGAELGLDC

UPP1

66

Q16831
GLLCRFCSVVSQKDD

RFPL4AL1

46

F8VTS6
LGTCCLDFRDFCLEI

SUSD2

51

Q9UGT4
KTCLICADTFRAGAF

SRP54

131

P61011
VRGTCEDASLCKRFA

LCMT1

26

Q9UIC8
SFCGANEIRRVFCDI

OR5T2

206

Q8NGG2
GIRCLDDIAKGSFVC

SETDB1

816

Q15047
IEEFCKSLGHACIRF

ABHD10

96

Q9NUJ1
FTCSKIIGRRFACFA

ANKFN1

16

Q8N957
GCAFLTYCERESALK

CELF4

96

Q9BZC1
CRRVVSGQKVCFADF

CHODL

21

Q9H9P2
CLLVARACFSDLQKG

CNGA2

156

Q16280
SSFKCIELIARCDGV

TMPRSS3

81

P57727
SGRFCDVFDKALVLC

VPS11

656

Q9H270
ECKECGKAFRLFSQL

ZFP30

411

Q9Y2G7
CLECGKFFRDRSNLI

ZSCAN20

961

P17040
EKPFVCRECGRAFFS

ZNF490

331

Q9ULM2
ADLAFAVRALCCKRA

SLC27A3

31

Q5K4L6
EAAFAAFLCCLCKIG

PTPA

191

Q15257
CKACADAGLLDESFL

UBE4B

826

O95155
TCCEKFGLKRSELFE

VAV1

81

P15498
ERPFACEVCGKAFAI

ZNF574

791

Q6ZN55
QECGLAGDFFIFCLK

TANGO6

586

Q9C0B7
CGKIFHLEVCSRDFA

STAM

76

Q92783
CGKIFHLEVCSRDFA

STAM2

76

O75886
FECNECGKAFSLLTL

ZNF780A

221

O75290
CDFQGLIGETAKLCR

SAXO2

186

Q658L1
DAVAPAAGFRCTFCK

ZNF536

266

O15090
FSVDKGEFTCPLCRQ

UBR3

1351

Q6ZT12
CDECGKAFITCRTLL

ZFP62

311

Q8NB50
AALNTEKRFPCEFCG

ZNF462

2406

Q96JM2
EKGFLCAECGRAFRI

ZNF648

501

Q5T619
DTIFECKLCRSLFRG

ZNF800

66

Q2TB10
ERAKLACFDSGDTIC

SLC9C2

881

Q5TAH2
AQREFGFLCDCTVAI

ZBTB2

16

Q8N680
RGITLVCLKCDFLAD

ZNF280C

681

Q8ND82
VCLKCDFLADSSGLD

ZNF280C

686

Q8ND82
GVRSFSCDICGKLFT

ZBTB10

746

Q96DT7
DDSCINFVSLGCLFI

ZMYM1

1041

Q5SVZ6
GSDVELICRCLFFLL

WDR3

846

Q9UNX4
FACKECGDTFRLKVL

ZNF275

101

Q9NSD4
CSDCGKVFLKAFALL

ZNF584

161

Q8IVC4
LRFSGVEKSFCSEGC

ZMYM3

646

Q14202
ETVAALRFPCEFCGK

ZNF692

441

Q9BU19
CADCGRAFIQKSELI

ZNF81

556

P51508
TCACFEILGFDILLD

TTLL13

366

A6NNM8
ECLRICDFGFAKQLR

RPS6KA1

551

Q15418