Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase binding	DAB2IP IRS4 NLRC3	6.87e-05	43	37	3	GO:0043548
GeneOntologyMolecularFunction	inhibitory MHC class I receptor activity	LILRB3 LILRB4	2.18e-04	12	37	2	GO:0032396
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase regulatory subunit binding	DAB2IP NLRC3	3.00e-04	14	37	2	GO:0036312
GeneOntologyMolecularFunction	MHC class I receptor activity	LILRB3 LILRB4	5.02e-04	18	37	2	GO:0032393
GeneOntologyMolecularFunction	phosphatidylinositol-4-phosphate binding	DAB2IP WASHC2C	2.02e-03	36	37	2	GO:0070273
GeneOntologyMolecularFunction	microfilament motor activity	MYH6 MYH7	2.25e-03	38	37	2	GO:0000146
HumanPheno	Thyroid hypoplasia	IRS4 TCOF1 GLI3	2.23e-05	23	13	3	HP:0005990
HumanPheno	Aplasia/Hypoplasia of the thyroid gland	IRS4 TCOF1 GLI3	2.89e-05	25	13	3	HP:0033079
HumanPheno	Thyroid dysgenesis	IRS4 TCOF1 GLI3	3.26e-05	26	13	3	HP:0008188
HumanPheno	Ebstein anomaly of the tricuspid valve	MYH7 FREM1	8.97e-05	6	13	2	HP:0010316
MousePheno	fused carpal bones	HOXD11 GLI3 ZIC2	3.54e-06	14	31	3	MP:0008915
MousePheno	abnormal neural crest cell morphology	TCOF1 GLI3 ZIC2	3.85e-05	30	31	3	MP:0009845
MousePheno	delayed neural tube closure	TCOF1 GLI3 ZIC2	4.26e-05	31	31	3	MP:0002621
MousePheno	abnormal multipotent stem cell morphology	TCOF1 GLI3 ZIC2	4.26e-05	31	31	3	MP:0002400
MousePheno	abnormal neural crest morphology	TCOF1 GLI3 ZIC2	4.69e-05	32	31	3	MP:0009846
MousePheno	abnormal carpal bone morphology	HOXD11 GLI3 ZIC2	6.71e-05	36	31	3	MP:0000554
MousePheno	abnormal upper lip morphology	TCOF1 GLI3 FREM1	7.29e-05	37	31	3	MP:0012523
MousePheno	abnormal metacarpal bone morphology	HOXD11 GLI3 ZIC2	7.29e-05	37	31	3	MP:0003073
MousePheno	abnormal pluripotent precursor cell morphology	TCOF1 GLI3 ZIC2	1.07e-04	42	31	3	MP:0002399
MousePheno	abnormal lip morphology	TCOF1 GLI3 FREM1	1.32e-04	45	31	3	MP:0003769
MousePheno	fused tarsal bones	GLI3 ZIC2	1.70e-04	9	31	2	MP:0008919
MousePheno	abnormal metopic suture morphology	GLI3 FREM1	2.12e-04	10	31	2	MP:0003842
MousePheno	bleb	GLI3 FREM1	3.66e-04	13	31	2	MP:0008854
MousePheno	decreased neural crest cell number	TCOF1 ZIC2	3.66e-04	13	31	2	MP:0009843
MousePheno	premature cranial suture closure	GLI3 FREM1	4.26e-04	14	31	2	MP:0000081
MousePheno	premature intramembranous bone ossification	GLI3 FREM1	4.26e-04	14	31	2	MP:0003418
MousePheno	premature craniofacial suture closure	GLI3 FREM1	4.26e-04	14	31	2	MP:0030435
MousePheno	abnormal rhombomere morphology	GLI3 ZIC2	6.34e-04	17	31	2	MP:0000933
MousePheno	abnormal neuromere morphology	GLI3 ZIC2	7.12e-04	18	31	2	MP:0003208
MousePheno	abnormal orbit morphology	TCOF1 GLI3	7.12e-04	18	31	2	MP:0010030
Domain	IRS_PTB	TLN2 IRS4	3.42e-04	14	37	2	IPR002404
Domain	IRS	TLN2 IRS4	3.42e-04	14	37	2	PF02174
Domain	Myosin_N	MYH6 MYH7	3.95e-04	15	37	2	IPR004009
Domain	Myosin_N	MYH6 MYH7	3.95e-04	15	37	2	PF02736
Domain	Myosin_tail_1	MYH6 MYH7	5.73e-04	18	37	2	PF01576
Domain	Myosin_tail	MYH6 MYH7	5.73e-04	18	37	2	IPR002928
Domain	Myosin-like_IQ_dom	MYH6 MYH7	6.39e-04	19	37	2	IPR027401
Domain	-	MYH6 MYH7	6.39e-04	19	37	2	4.10.270.10
Domain	-	DAB2IP TLN2 IRS4 DGKK MSN	9.84e-04	391	37	5	2.30.29.30
Domain	FERM_CS	TLN2 MSN	1.03e-03	24	37	2	IPR019747
Domain	PH_dom-like	DAB2IP TLN2 IRS4 DGKK MSN	1.44e-03	426	37	5	IPR011993
Domain	FERM_N	TLN2 MSN	1.94e-03	33	37	2	IPR018979
Domain	FERM_N	TLN2 MSN	1.94e-03	33	37	2	PF09379
Domain	MYOSIN_MOTOR	MYH6 MYH7	2.57e-03	38	37	2	PS51456
Domain	Myosin_head	MYH6 MYH7	2.57e-03	38	37	2	PF00063
Domain	Myosin_head_motor_dom	MYH6 MYH7	2.57e-03	38	37	2	IPR001609
Domain	MYSc	MYH6 MYH7	2.57e-03	38	37	2	SM00242
Domain	FERM_M	TLN2 MSN	3.74e-03	46	37	2	PF00373
Domain	FERM_central	TLN2 MSN	4.24e-03	49	37	2	IPR019748
Domain	FERM_domain	TLN2 MSN	4.24e-03	49	37	2	IPR000299
Domain	-	TLN2 MSN	4.24e-03	49	37	2	1.20.80.10
Domain	FERM_1	TLN2 MSN	4.41e-03	50	37	2	PS00660
Domain	FERM_2	TLN2 MSN	4.41e-03	50	37	2	PS00661
Domain	Band_41_domain	TLN2 MSN	4.41e-03	50	37	2	IPR019749
Domain	B41	TLN2 MSN	4.41e-03	50	37	2	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	TLN2 MSN	4.41e-03	50	37	2	IPR014352
Domain	FERM_3	TLN2 MSN	4.41e-03	50	37	2	PS50057
Pubmed	Knockdown of receptor interacting protein 140 (RIP140) alleviated lipopolysaccharide-induced inflammation, apoptosis and permeability in pulmonary microvascular endothelial cells by regulating C-terminal binding protein 2 (CTBP2).	NRIP1 CTBP2	1.10e-06	2	37	2	35113002
Pubmed	All-atom molecular dynamics simulations of actin-myosin interactions: a comparative study of cardiac α myosin, β myosin, and fast skeletal muscle myosin.	MYH6 MYH7	1.10e-06	2	37	2	24224850
Pubmed	Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart.	MYH6 MYH7	1.10e-06	2	37	2	17575272
Pubmed	Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression.	MYH6 MYH7	1.10e-06	2	37	2	21526716
Pubmed	Myosin heavy chain composition and the economy of contraction in healthy and diseased human myocardium.	MYH6 MYH7	1.10e-06	2	37	2	16088376
Pubmed	Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone.	MYH6 MYH7	1.10e-06	2	37	2	18480046
Pubmed	Complete sequence of human cardiac alpha-myosin heavy chain gene and amino acid comparison to other myosins based on structural and functional differences.	MYH6 MYH7	1.10e-06	2	37	2	1776652
Pubmed	Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene.	MYH6 MYH7	1.10e-06	2	37	2	9884344
Pubmed	Murine pulmonary myocardium: developmental analysis of cardiac gene expression.	MYH6 MYH7	1.10e-06	2	37	2	7919499
Pubmed	Role of microtubules versus myosin heavy chain isoforms in contractile dysfunction of hypertrophied murine cardiocytes.	MYH6 MYH7	1.10e-06	2	37	2	12750067
Pubmed	Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.	MYH6 MYH7	1.10e-06	2	37	2	9541509
Pubmed	Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.	MYH6 MYH7	1.10e-06	2	37	2	23580644
Pubmed	Long-Read Sequence Confirmed a Large Deletion Including MYH6 and MYH7 in an Infant of Atrial Septal Defect and Atrial Arrhythmias.	MYH6 MYH7	1.10e-06	2	37	2	34384224
Pubmed	Characterization of human cardiac myosin heavy chain genes.	MYH6 MYH7	1.10e-06	2	37	2	2726733
Pubmed	Human cardiac myosin heavy chain gene mapped within chromosome region 14q11.2----q13.	MYH6 MYH7	1.10e-06	2	37	2	2494889
Pubmed	Human cardiac myosin heavy chain genes and their linkage in the genome.	MYH6 MYH7	1.10e-06	2	37	2	3037493
Pubmed	β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes.	MYH6 MYH7	1.10e-06	2	37	2	21778428
Pubmed	Structural organization of the human cardiac alpha-myosin heavy chain gene (MYH6).	MYH6 MYH7	1.10e-06	2	37	2	8307559
Pubmed	β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations.	MYH6 MYH7	1.10e-06	2	37	2	24829265
Pubmed	Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart.	MYH6 MYH7	1.10e-06	2	37	2	2036722
Pubmed	Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector.	MYH6 MYH7	1.10e-06	2	37	2	25937279
Pubmed	Myocardial contraction is 5-fold more economical in ventricular than in atrial human tissue.	MYH6 MYH7	1.10e-06	2	37	2	15621050
Pubmed	Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium.	MYH6 MYH7	1.10e-06	2	37	2	2969919
Pubmed	Endogenous retinoic acid signaling colocalizes with advanced expression of the adult smooth muscle myosin heavy chain isoform during development of the ductus arteriosus.	MYH6 MYH7	3.30e-06	3	37	2	8620598
Pubmed	Mutation in myosin heavy chain 6 causes atrial septal defect.	MYH6 MYH7	3.30e-06	3	37	2	15735645
Pubmed	Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy.	MYH6 MYH7	3.30e-06	3	37	2	18362229
Pubmed	Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study.	MYH6 MYH7	3.30e-06	3	37	2	1939265
Pubmed	Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy.	MYH6 MYH7	3.30e-06	3	37	2	20923879
Pubmed	Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro.	MYH6 MYH7	3.30e-06	3	37	2	1694848
Pubmed	Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140.	NRIP1 CTBP2	3.30e-06	3	37	2	14736873
Pubmed	Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor.	LILRB3 LILRB4	3.30e-06	3	37	2	9278324
Pubmed	The effects of slow skeletal troponin I expression in the murine myocardium are influenced by development-related shifts in myosin heavy chain isoform.	MYH6 MYH7	3.30e-06	3	37	2	22966157
Pubmed	Conotruncal anomalies in the trisomy 16 mouse: an immunohistochemical analysis with emphasis on the involvement of the neural crest.	MYH6 MYH7	3.30e-06	3	37	2	11066038
Pubmed	Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.	MYH6 MYH7	3.30e-06	3	37	2	18755891
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	DAB2IP CTBP2 IRS4 CLTCL1 INTS1 MSN	4.48e-06	411	37	6	36652389
Pubmed	A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing.	LILRB3 LILRB4	6.60e-06	4	37	2	9151699
Pubmed	Altered cardiac phenotype in transgenic mice carrying the delta337 threonine thyroid hormone receptor beta mutant derived from the S family.	MYH6 MYH7	6.60e-06	4	37	2	9927321
Pubmed	Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth.	MYH6 MYH7	6.60e-06	4	37	2	25900833
Pubmed	Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly.	MYH6 MYH7	6.60e-06	4	37	2	11815426
Pubmed	Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins.	GLI3 ZIC2	6.60e-06	4	37	2	11053430
Pubmed	Androgen receptor is expressed in mouse cardiomyocytes at prenatal and early postnatal developmental stages.	MYH6 MYH7	6.60e-06	4	37	2	28806941
Pubmed	Changes in expression of nonmuscle myosin heavy chain isoforms during muscle and nonmuscle tissue development.	MYH6 MYH7	6.60e-06	4	37	2	8482409
Pubmed	Murine cardiac progenitor cells require visceral embryonic endoderm and primitive streak for terminal differentiation.	MYH6 MYH7	6.60e-06	4	37	2	9389458
Pubmed	Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure.	MYH6 MYH7	1.10e-05	5	37	2	12933792
Pubmed	A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins.	FAM184B INTS1	1.10e-05	5	37	2	16807365
Pubmed	Developmental regulation of myosin gene expression in mouse cardiac muscle.	MYH6 MYH7	1.10e-05	5	37	2	2277065
Pubmed	Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling.	MYH6 MYH7	1.10e-05	5	37	2	24091702
Pubmed	Recruitment of intra- and extracardiac cells into the myocardial lineage during mouse development.	MYH6 MYH7	1.10e-05	5	37	2	12629673
Pubmed	Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis.	MYH6 MYH7	1.10e-05	5	37	2	2552320
Pubmed	Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation.	MYH6 MYH7	1.10e-05	5	37	2	17192267
Pubmed	Poly(C)-binding protein 1 (Pcbp1) regulates skeletal muscle differentiation by modulating microRNA processing in myoblasts.	MYH6 MYH7	1.65e-05	6	37	2	28381556
Pubmed	Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways.	LILRB3 LILRB4	1.65e-05	6	37	2	9079806
Pubmed	A duplicated zone of polarizing activity in polydactylous mouse mutants.	HOXD11 GLI3	1.65e-05	6	37	2	7628698
Pubmed	Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition.	NRIP1 CTBP2	1.65e-05	6	37	2	15060175
Pubmed	Physical and functional interactions between Zic and Gli proteins.	GLI3 ZIC2	1.65e-05	6	37	2	11238441
Pubmed	Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin.	MYH6 MYH7	2.30e-05	7	37	2	9004034
Pubmed	Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes.	LILRB3 LILRB4	2.30e-05	7	37	2	19658091
Pubmed	Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells.	LILRB3 LILRB4	2.30e-05	7	37	2	17998301
Pubmed	Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh.	HOXD11 GLI3	2.30e-05	7	37	2	15102708
Pubmed	A dual role for Hox genes in limb anterior-posterior asymmetry.	HOXD11 GLI3	2.30e-05	7	37	2	15192229
Pubmed	Hox genes regulate digit patterning by controlling the wavelength of a Turing-type mechanism.	HOXD11 GLI3	2.30e-05	7	37	2	23239739
Pubmed	Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men.	DAB2IP CTBP2	2.30e-05	7	37	2	19866473
Pubmed	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.	MYH6 MYH7	2.30e-05	7	37	2	16819597
Pubmed	Myosin regulatory light chains are required to maintain the stability of myosin II and cellular integrity.	MYH6 MYH7	2.30e-05	7	37	2	21126233
Pubmed	Genetic interaction of Gli3 and Alx4 during limb development.	HOXD11 GLI3	2.30e-05	7	37	2	15968591
Pubmed	Novel roles of cardiac-derived erythropoietin in cardiac development and function.	MYH6 MYH7	2.30e-05	7	37	2	38382296
Pubmed	A threshold of GATA4 and GATA6 expression is required for cardiovascular development.	MYH6 MYH7	3.07e-05	8	37	2	16847256
Pubmed	Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene.	MYH6 MYH7	3.07e-05	8	37	2	3864153
Pubmed	A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.	LILRB3 LILRB4	3.07e-05	8	37	2	9548455
Pubmed	Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.	DAB2IP CTBP2	3.07e-05	8	37	2	18794092
Pubmed	Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac development.	MYH6 MYH7	3.07e-05	8	37	2	22553207
Pubmed	Established prostate cancer susceptibility variants are not associated with disease outcome.	DAB2IP CTBP2	3.07e-05	8	37	2	19423541
Pubmed	Individual and cumulative association of prostate cancer susceptibility variants with clinicopathologic characteristics of the disease.	DAB2IP CTBP2	3.07e-05	8	37	2	20450899
Pubmed	Prognostic significance of prostate cancer susceptibility variants on prostate-specific antigen recurrence after radical prostatectomy.	DAB2IP CTBP2	3.07e-05	8	37	2	19900942
Pubmed	A long noncoding RNA protects the heart from pathological hypertrophy.	MYH6 MYH7	3.07e-05	8	37	2	25119045
Pubmed	Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates.	HOXD11 GLI3	3.07e-05	8	37	2	34610275
Pubmed	Increased Postnatal Cardiac Hyperplasia Precedes Cardiomyocyte Hypertrophy in a Model of Hypertrophic Cardiomyopathy.	MYH6 MYH7	3.07e-05	8	37	2	28659827
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	ZSCAN29 IRS4 HOXD11 CDIPT ZIC2 INTS1	3.23e-05	583	37	6	29844126
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	KCTD7 CTBP2 NUDT7 CLTCL1 WASHC2C FREM1 CREBZF MSN	3.39e-05	1215	37	8	15146197
Pubmed	Bone morphology is regulated modularly by global and regional genetic programs.	HOXD11 GLI3	3.95e-05	9	37	2	31221640
Pubmed	Molecular characterization of the ventricular conduction system in the developing mouse heart: topographical correlation in normal and congenitally malformed hearts.	MYH6 MYH7	3.95e-05	9	37	2	11164852
Pubmed	Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality.	MYH6 MYH7	3.95e-05	9	37	2	26487682
Pubmed	Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants.	HOXD11 GLI3	3.95e-05	9	37	2	23644062
Pubmed	Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.	HOXD11 GLI3	4.93e-05	10	37	2	12215652
Pubmed	Single-Cell Lineage Tracing Reveals that Oriented Cell Division Contributes to Trabecular Morphogenesis and Regional Specification.	MYH6 MYH7	4.93e-05	10	37	2	27052172
Pubmed	CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.	GLI3 ZIC2	4.93e-05	10	37	2	18298960
Pubmed	Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks.	MYH6 GLI3	4.93e-05	10	37	2	33006313
Pubmed	Function and regulation of Alx4 in limb development: complex genetic interactions with Gli3 and Shh.	HOXD11 GLI3	4.93e-05	10	37	2	16039644
Pubmed	Suppression of atrial myosin gene expression occurs independently in the left and right ventricles of the developing mouse heart.	MYH6 MYH7	4.93e-05	10	37	2	10679931
Pubmed	Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.	LILRB3 LILRB4	4.93e-05	10	37	2	18802077
Pubmed	Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.	HOXD11 GLI3	4.93e-05	10	37	2	22841643
Pubmed	Characterization of Opr deficiency in mouse brain: subtle defects in dorsomedial telencephalon and medioventral forebrain.	GLI3 ZIC2	4.93e-05	10	37	2	15736266
Pubmed	Assembly of the cochlear gap junction macromolecular complex requires connexin 26.	TLN2 MYH6	4.93e-05	10	37	2	24590285
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	MYH6 CTBP2 MYH7 IRS4 CLTCL1 MSN	5.76e-05	647	37	6	26618866
Pubmed	Prostate cancer risk associated loci in African Americans.	DAB2IP CTBP2	6.02e-05	11	37	2	19549807
Pubmed	Control of p21Cip by BRCA1-associated protein is critical for cardiomyocyte cell cycle progression and survival.	MYH6 MYH7	6.02e-05	11	37	2	31286143
Pubmed	FGF8 signaling patterns the telencephalic midline by regulating putative key factors of midline development.	GLI3 ZIC2	6.02e-05	11	37	2	18547559
Pubmed	A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud.	HOXD11 GLI3	6.02e-05	11	37	2	19248778
Pubmed	Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice.	MYH6 MYH7	6.02e-05	11	37	2	16374517
Pubmed	The thyroid hormone receptor alpha1 protein is expressed in embryonic postmitotic neurons and persists in most adult neurons.	MYH6 MYH7	6.02e-05	11	37	2	20739404
Cytoband	19q13.4	ZIM2 LILRB3 LILRB4	3.65e-05	79	37	3	19q13.4
Cytoband	14q12	MYH6 MYH7	9.14e-04	55	37	2	14q12
GeneFamily	CD molecules\|Inhibitory leukocyte immunoglobulin like receptors	LILRB3 LILRB4	1.28e-05	5	21	2	1182
GeneFamily	Myosin heavy chains	MYH6 MYH7	1.34e-04	15	21	2	1098
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	TLN2 MSN	1.52e-03	50	21	2	1293
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZSCAN29 ZIM2 GLI3 ZIC2	8.61e-03	718	21	4	28
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Fibroblasts-Monocytes-Macrophages\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NRIP1 CLSPN INTS1 LILRB4	7.39e-06	151	37	4	f13a117ae26ae525da4f3e837d8f204d00dc6ee3
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLN2 ABCA13 FREM1 DGKK	1.61e-05	184	37	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLN2 ABCA13 FREM1 DGKK	1.61e-05	184	37	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLN2 ABCA13 FREM1 DGKK	1.61e-05	184	37	4	2b19a8c5f823e00812908b23e66bb4e563278aff
Disease	Caveolinopathy	MYH6 MYH7	7.72e-06	4	34	2	cv:C5679790
Disease	Cardiomyopathy, Familial Hypertrophic, 1 (disorder)	MYH6 MYH7	7.72e-06	4	34	2	C3495498
Disease	Hypertrophic cardiomyopathy 1	MYH6 MYH7	7.72e-06	4	34	2	cv:C3495498
Disease	CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 1	MYH6 MYH7	7.72e-06	4	34	2	192600
Disease	Idiopathic hypertrophic subaortic stenosis	MYH6 MYH7	2.70e-05	7	34	2	C0700053
Disease	Obstructive asymmetric septal hypertrophy	MYH6 MYH7	2.70e-05	7	34	2	C0597124
Disease	Cardiomyopathy, Hypertrophic, Familial	MYH6 MYH7	4.62e-05	9	34	2	C0949658
Disease	Muscular dystrophy, limb-girdle, autosomal dominant	MYH6 MYH7	5.77e-05	10	34	2	cv:C5675009
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH6 MYH7	5.77e-05	10	34	2	DOID:0110454 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH6 MYH7	5.77e-05	10	34	2	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH6 MYH7	5.77e-05	10	34	2	DOID:3429 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH6 MYH7	5.77e-05	10	34	2	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH6 MYH7	5.77e-05	10	34	2	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH6 MYH7	5.77e-05	10	34	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH6 MYH7	5.77e-05	10	34	2	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH6 MYH7	5.77e-05	10	34	2	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH6 MYH7	8.44e-05	12	34	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH6 MYH7	8.44e-05	12	34	2	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH6 MYH7	9.97e-05	13	34	2	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH6 MYH7	1.34e-04	15	34	2	DOID:0050646 (implicated_via_orthology)
Disease	Myocardial Infarction	DAB2IP NRIP1 MYH7	1.80e-04	95	34	3	C0027051
Disease	Primary familial hypertrophic cardiomyopathy	MYH6 MYH7	2.93e-04	22	34	2	cv:C0949658
Disease	Hypertrophic obstructive cardiomyopathy	MYH6 MYH7	3.80e-04	25	34	2	C4551472
Disease	Limb-girdle muscular dystrophy	MYH6 MYH7	4.12e-04	26	34	2	cv:C0686353
Disease	Exencephaly	GLI3 ZIC2	4.78e-04	28	34	2	C0266453
Disease	Neurenteric Cyst	GLI3 ZIC2	4.78e-04	28	34	2	C0027806
Disease	Iniencephaly	GLI3 ZIC2	4.78e-04	28	34	2	C0152234
Disease	Acrania	GLI3 ZIC2	4.78e-04	28	34	2	C0702169
Disease	Tethered Cord Syndrome	GLI3 ZIC2	4.78e-04	28	34	2	C0080218
Disease	Diastematomyelia	GLI3 ZIC2	4.78e-04	28	34	2	C0011999
Disease	Spinal Cord Myelodysplasia	GLI3 ZIC2	4.78e-04	28	34	2	C0344479
Disease	Craniorachischisis	GLI3 ZIC2	5.13e-04	29	34	2	C0152426
Disease	Neural Tube Defects	GLI3 ZIC2	5.49e-04	30	34	2	C0027794
Disease	Primary familial dilated cardiomyopathy	MYH6 MYH7	5.49e-04	30	34	2	cv:C0340427
Disease	hemorrhoid	TET2 CTBP2 HOXD11	6.47e-04	147	34	3	EFO_0009552
Disease	Heart Failure, Diastolic	MYH6 MYH7	6.65e-04	33	34	2	C1135196
Disease	Primary dilated cardiomyopathy	MYH6 MYH7	7.06e-04	34	34	2	cv:C0007193
Disease	colorectal cancer (is_marker_for)	DAB2IP TET2 IRS4	7.83e-04	157	34	3	DOID:9256 (is_marker_for)
Disease	orofacial cleft	TLN2 ZIC2	8.37e-04	37	34	2	MONDO_0000358
Disease	response to simvastatin, myopathy	NUDT7 ABCA13	1.03e-03	41	34	2	EFO_0004145, GO_1903491

Protein segments in the cluster

Peptide	Gene	Start	Entry
SEQASLEMREAAATE	CTBP2	326	P56545
LNDSADLRDLATSMD	ABCA13	2506	Q86UQ4
TAARNMAALDAADRA	CDIPT	196	O14735
ASIDDAEELMATDNA	MYH7	321	P12883
SAAAAAADNERSHLM	DAB2IP	111	Q5VWQ8
AEDETALQSALDAMN	DGKK	1171	Q5KSL6
ESLTMDADANLNDED	GLI3	1076	P10071
SRRQDGAMSSSDAED	KCTD7	11	Q96MP8
DDGARSMAEALASNR	NLRC3	736	Q7RTR2
DSRALENRGADASMA	INTS1	1851	Q8N201
AEEDRQMDTEAAASE	LILRB4	391	Q8NHJ6
DAEEDLYDAAAASAM	DOP1B	1871	Q9Y3R5
ALNTRQDEAEASMEA	FAM184B	51	Q9ULE4
EQEKAAMDSARLSAA	ECPAS	1321	Q5VYK3
QGSMLRASDVDASDD	FREM1	541	Q5H8C1
LADDSDRSHRNNEMA	NRIP1	831	P48552
NGAEASADLRADAMA	MSN	486	P26038
EDRQMDTEAAASEAS	LILRB3	576	O75022
TDMDDAATALREAQE	NUDT7	81	P0C024
ESDSEDEASVAARRM	LRRC58	351	Q96CX6
AAAAAEEAAMQRELL	HOXD11	116	P31277
LAEDAAAAIDNMNES	PPIE	56	Q9UNP9
SDNDDDTHVRMDFAR	IRS4	1231	O14654
LREMFSDSRSNNDDD	TAF7L	321	Q5H9L4
RLSSQASMGDDEDDD	TMEM151B	506	Q8IW70
ESDSDREALAAMNAA	TCOF1	481	Q13428
MVDVERSNAAAAALD	MYH6	1431	P13533
DAMQHAAESRDAELA	CLTCL1	1536	P53675
ASQMDLFHRDSDDDQ	CLSPN	1146	Q9HAW4
ENEDARSMAAAAASL	TMEM9	131	Q9P0T7
DDDDEAAAAEMQRFS	CREBZF	146	Q9NS37
RLAAQESSEAEDMSV	WASHC2C	1026	Q9Y4E1
DDNNSDVTSDDDMTR	ZIM2	6	Q9NZV7
TSDLVNAMRSDAEAE	TLN2	836	Q9Y4G6
AVAQESDSDDMDLEA	ZSCAN29	376	Q8IWY8
CDADDADNASKLAAM	TET2	296	Q6N021
AAAAAAAAEMQDREL	ZIC2	26	O95409
AAAEMQDRELSLAAA	ZIC2	31	O95409