Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	filopodium tip	MYO3A UBE2K MYO9B	9.67e-06	20	44	3	GO:0032433
GeneOntologyCellularComponent	filopodium	MYO3A LRRC7 UBE2K MYO9B	1.29e-04	123	44	4	GO:0030175
Domain	Myosin_head_motor_dom	MYO3A MYO9B	3.94e-03	38	46	2	IPR001609
Domain	MYOSIN_MOTOR	MYO3A MYO9B	3.94e-03	38	46	2	PS51456
Domain	Myosin_head	MYO3A MYO9B	3.94e-03	38	46	2	PF00063
Domain	MYSc	MYO3A MYO9B	3.94e-03	38	46	2	SM00242
Domain	P-loop_NTPase	MYO3A ABCB7 DNAH5 MYO9B DHX37 AK5 AFG3L2	4.42e-03	848	46	7	IPR027417
Domain	AAA+_ATPase	ABCB7 DNAH5 AFG3L2	5.35e-03	144	46	3	IPR003593
Domain	AAA	ABCB7 DNAH5 AFG3L2	5.35e-03	144	46	3	SM00382
Domain	Znf_FYVE_PHD	DIDO1 ING3 WDFY2	5.66e-03	147	46	3	IPR011011
Domain	HEAT	SCYL1 HEATR1	6.23e-03	48	46	2	PF02985
Domain	HEAT	SCYL1 HEATR1	8.99e-03	58	46	2	IPR000357
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	DIDO1 HEATR1 DBT IK MYO9B DHX37 PRRC2C TOP2A	6.22e-06	759	46	8	35915203
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DIDO1 HEATR1 DBT IK HBD DHX37 PRRC2C TOP2A AFG3L2	3.37e-05	1257	46	9	36526897
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	MAD2L2 LMAN2L EZH1 PRRC2C TOP2A AFG3L2	3.45e-05	469	46	6	27634302
Pubmed	EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.	LRRC7 KCNH5	4.77e-05	8	46	2	24348519
Pubmed	Ezh2-dependent methylation in oral epithelia promotes secondary palatogenesis.	EZH1 TOP2A	6.12e-05	9	46	2	37435868
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	DBT DNAJC28 HBD DNAH5 AFG3L2	7.54e-05	331	46	5	29199018
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	HEATR1 DBT IK NCLN DNAH5 DHX37 TOP2A XPOT MYBPC1	8.88e-05	1425	46	9	30948266
Pubmed	Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37.	DCX TOP2A	1.32e-04	13	46	2	36029179
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	DIDO1 NCLN MYO9B TOP2A AFG3L2 XPOT	1.35e-04	601	46	6	33658012
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ABCB7 HEATR1 LMAN2L ING3 NCLN TOP2A AFG3L2 XPOT	1.62e-04	1203	46	8	29180619
Pubmed	Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.	DIDO1 MYO3A MYBPC1	1.91e-04	84	46	3	15203218
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DIDO1 NCLN HPS5 DHX37 PRRC2C AFG3L2	2.07e-04	650	46	6	38777146
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	MAD2L2 ING3 IK DHX37 TOP2A	2.07e-04	411	46	5	35182466
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DIDO1 HEATR1 IK DHX37 PRRC2C XPOT	2.12e-04	653	46	6	22586326
Pubmed	LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization.	PRRC2C TOP2A	2.30e-04	17	46	2	37072811
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SEH1L DIDO1 HEATR1 ING3 IK NCLN TOP2A AFG3L2	2.66e-04	1294	46	8	30804502
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	DIDO1 ABCB7 LMAN2L NCLN DHX37 PRRC2C AFG3L2 XPOT	2.70e-04	1297	46	8	33545068
Pubmed	Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.	ABCB7 DBT NCLN DHX37 AFG3L2	2.77e-04	438	46	5	32628020
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	DIDO1 HEATR1 DBT NCLN DHX37 TOP2A AFG3L2 XPOT	3.01e-04	1318	46	8	30463901
Pubmed	Mapping the Genetic Landscape of Human Cells.	SCYL1 SEH1L ABCB7 DHX37 AFG3L2	3.17e-04	451	46	5	30033366
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	PRRC2C TOP2A AFG3L2 XPOT	3.51e-04	253	46	4	29911972
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SEH1L HEATR1 IK MYO9B DHX37 TOP2A AFG3L2 XPOT	3.59e-04	1353	46	8	29467282
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	ABCB7 NCLN XPOT	3.59e-04	104	46	3	31240132
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	DBT MYO9B DHX37 PRRC2C AFG3L2	4.46e-04	486	46	5	30940648
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	SCYL1 SEH1L DIDO1 HEATR1 ING3 DHX37	4.56e-04	754	46	6	35906200
Pubmed	Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.	HEATR1 AFG3L2 XPOT	4.58e-04	113	46	3	30352685
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	IK NCLN DHX37 AFG3L2 XPOT	4.94e-04	497	46	5	36774506
Pubmed	Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation.	EZH1 DCX	5.04e-04	25	46	2	26621269
Pubmed	A MicroRNA Profile in Fmr1 Knockout Mice Reveals MicroRNA Expression Alterations with Possible Roles in Fragile X Syndrome.	DCX AFG3L2	5.04e-04	25	46	2	24906954
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	HEATR1 MYO9B XPOT	5.46e-04	120	46	3	27320910
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	SEH1L DIDO1 UBE2K IK PRRC2C TOP2A XPOT	5.75e-04	1103	46	7	34189442
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	SCYL1 ABCB7 HEATR1 DBT NCLN DNAJC28 TOP2A AFG3L2	6.98e-04	1496	46	8	32877691
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	DIDO1 HEATR1 IK PRRC2C TOP2A	7.74e-04	549	46	5	38280479
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	MYO3A HEATR1 NCLN HBD MYO9B TOP2A	8.22e-04	844	46	6	25963833
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	ABCB7 IK TOP2A AFG3L2 XPOT	8.45e-04	560	46	5	35241646
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	ING3 EZH1	8.80e-04	33	46	2	26864203
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ABCB7 HEATR1 ING3 MYO9B PRRC2C TOP2A	8.89e-04	857	46	6	25609649
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	DNAH5 MYO9B PRRC2C TOP2A	9.70e-04	332	46	4	37433992
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	SEH1L HEATR1 TOP2A PAEP	9.70e-04	332	46	4	25693804
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	MAD2L2 DHX37 AFG3L2	1.04e-03	150	46	3	30154076
Pubmed	Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.	ABCB7 DBT DNAJC28 AFG3L2	1.09e-03	343	46	4	28130547
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	HEATR1 NCLN PRRC2C AFG3L2 XPOT	1.20e-03	606	46	5	36538041
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	SEH1L ABCB7 IK NCLN DHX37 AFG3L2 XPOT	1.24e-03	1257	46	7	37317656
Pubmed	Novel Cul3 binding proteins function to remodel E3 ligase complexes.	LRRC7 LRFN2	1.29e-03	40	46	2	25011449
Pubmed	Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors.	UBE2K IK EZH1 DYRK2	1.29e-03	359	46	4	35559673
Cytoband	1p31	DBT AK5	2.04e-04	21	46	2	1p31
Cytoband	Ensembl 112 genes in cytogenetic band chr18p11	SEH1L AFG3L2 MC2R	1.24e-03	210	46	3	chr18p11
GeneFamily	PHD finger proteins	DIDO1 ING3	1.46e-02	90	37	2	88
ToppCell	LPS_only-Unknown\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOK6 AFF2 COL28A1 KCNH5	6.64e-06	115	47	4	7a733f6987b40ec497a03734b79ed5355ad3a2fc
ToppCell	LPS_only-Unknown-Endothelial-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOK6 AFF2 COL28A1 KCNH5	6.64e-06	115	47	4	c67145d3cd9243994a141749b426ff2a6dcc8d93
ToppCell	LPS_only-Unknown-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOK6 AFF2 COL28A1 KCNH5	6.64e-06	115	47	4	ad5298c2ad8bf94fa13c2e50b0799e929473ef59
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb\|Cerebellum / BrainAtlas - Mouse McCarroll V32	DOK6 LRRC7 AFF2 PRRC2C	1.84e-05	149	47	4	6e9ca280a599d96f8956ef26f2a46b9484de5488
Computational	Neighborhood of JAK3	AFF2 MYO9B TBC1D22A MC2R	1.37e-04	96	30	4	MORF_JAK3
Disease	hemoglobin measurement, hemoglobin A2 measurement	HBD HBD	2.48e-05	5	47	2	EFO_0004509, EFO_0005845
Disease	hemoglobin E disease	HBD HBD	3.71e-05	6	47	2	MONDO_0016243
Disease	Miller Dieker syndrome	MAD2L2 DCX	9.81e-04	29	47	2	C0265219
Disease	Ataxia, Spinocerebellar	SCYL1 AFG3L2	1.35e-03	34	47	2	C0087012
Disease	Spinocerebellar Ataxia Type 2	SCYL1 AFG3L2	1.35e-03	34	47	2	C0752121
Disease	Spinocerebellar Ataxia Type 1	SCYL1 AFG3L2	1.35e-03	34	47	2	C0752120
Disease	Spinocerebellar Ataxia Type 5	SCYL1 AFG3L2	1.35e-03	34	47	2	C0752123
Disease	Spinocerebellar Ataxia Type 7	SCYL1 AFG3L2	1.35e-03	34	47	2	C0752125
Disease	Spinocerebellar Ataxia Type 6 (disorder)	SCYL1 AFG3L2	1.35e-03	34	47	2	C0752124
Disease	Spinocerebellar Ataxia Type 4	SCYL1 AFG3L2	1.43e-03	35	47	2	C0752122

Protein segments in the cluster

Peptide	Gene	Start	Entry
MEFVNFLKNPKQYQD	AFG3L2	321	Q9Y4W6
MEYFKQNASKVAQIP	AFF2	1186	P51816
QNKQPFMVAFFKATE	BMP7	271	P18075
KPKMFFIQNYVVSEG	CFLAR	351	O15519
KQVMNAYRVKPAVFD	NCLN	511	Q969V3
RFNQKGEVYKAQIMN	DBT	431	P11182
NPKKFKINYTVANEA	PAEP	96	P09466
IFQKRKKYNVPVQMS	MAD2L2	41	Q9UI95
FPAMITPAYQNAKKA	NRAP	311	Q86VF7
MNFKQNAAPLVKYFQ	AK5	276	Q9Y6K8
PQQQKASMTKKVYQF	LRRC7	1016	Q96NW7
KQAKAAAAFVMFPVQ	HPS5	156	Q9UPZ3
MVPYNVSFKTKQNNI	KCNH5	231	Q8NCM2
QRVSEFFMNAKKNKP	ING3	41	Q9NXR8
NPLIYTLKNAQMKNA	OR4C46	281	A6NHA9
FMNPYNAVLTKKFQV	FBXO39	96	Q8N4B4
VMEYQKQKLQSQYFP	DNAJC28	166	Q9NX36
KQQERVFPYISAMVN	LMAN2L	166	Q9H0V9
PENFQIIKNFVKTMA	COL28A1	811	Q2UY09
MASNFNDIVKQGYVK	DOK6	1	Q6PKX4
FQNYGQALFKPMKQT	FAM20C	276	Q8IXL6
NFFKKVEYTKNVNPN	DCX	131	O43602
INMQSVAKFVTKAYP	DIDO1	1061	Q9BTC0
YSFQVINKTVKMVIP	HEATR1	1341	Q9H583
KEFTPQMQAAYQKVV	HBD	121	P02042
QMKALNVEKVINFPF	DHX37	711	Q8IY37
PNAMAKVQIFEYNEN	SEH1L	191	Q96EE3
PEQAMKQYMQKLTAF	DYRK2	156	Q92630
LSNRYNMPFKAQIQK	DNAH5	1596	Q8TE73
YQQKIIPVVVKMFSS	SCYL1	346	Q96KG9
KMNSIVYQKQFQSAP	PRRC2C	2701	Q9Y520
VYQKQFQSAPATVRM	PRRC2C	2706	Q9Y520
VVPFMFKYAVDSLNQ	ABCB7	156	O75027
KNKNLQAPMYFFICS	MC2R	51	Q01718
YNKMTPVKNYQAHQS	WDFY2	101	Q96P53
MGAKALYVANFAKVQ	EZH1	36	Q92800
QVQMAKLYQDDKQFV	TREH	41	O43280
QMKTAGYPEVNIQNF	SPTBN4	191	Q9H254
EYMNNKEALPKAAFQ	IK	491	Q13123
DNYTFAQPGIQMKVK	TBC1D22A	376	Q8WUA7
PIVKVSKNKQEMAFY	TOP2A	576	P11388
ANQYKQNPEMFKQTA	UBE2K	131	P61086
AKFKIQVSPFLQQMF	XPOT	751	O43592
YRMIPASNKAFVVNN	LRFN2	466	Q9ULH4
SNNRVYQTPKKMNNV	MYO3A	1181	Q8NEV4
NPKYVKMYENQQLGK	MYO9B	196	Q13459
EMQIIKAKDNFAGNY	MYBPC1	126	Q00872