Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	DRD4 GPR18 RAMP2 OR4K2 OR1B1 OR4M1 GPR52 OR10X1 TAAR6 TAS2R5 CELSR2 P2RY4 LPAR2 ACKR1 GPR148	4.68e-05	884	103	15	GO:0004930
GeneOntologyMolecularFunction	RNA polymerase I core binding	RRN3P2 RRN3	1.57e-04	4	103	2	GO:0001042
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	DRD4 GPR18 RAMP2 OR4K2 OR1B1 PDGFRA OR4M1 GPR52 OR10X1 TAAR6 TAS2R5 CSF2RB CELSR2 P2RY4 LPAR2 ACKR1 M6PR GPR148	1.79e-04	1353	103	18	GO:0004888
GeneOntologyBiologicalProcess	membrane lipid metabolic process	ABCA2 SPTSSA SAMD8 PGAP4 PIGV GBA2 UGCG MFSD8 M6PR	1.59e-06	229	99	9	GO:0006643
GeneOntologyBiologicalProcess	glycolipid metabolic process	ABCA2 PGAP4 PIGV GBA2 UGCG MFSD8 M6PR	1.71e-06	119	99	7	GO:0006664
GeneOntologyBiologicalProcess	liposaccharide metabolic process	ABCA2 PGAP4 PIGV GBA2 UGCG MFSD8 M6PR	1.81e-06	120	99	7	GO:1903509
GeneOntologyBiologicalProcess	phosphatidylinositol acyl-chain remodeling	MBOAT7 PLA2G4E LCLAT1	2.12e-06	6	99	3	GO:0036149
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	DRD4 GPR18 RAMP2 OR4K2 SH2B3 OR1B1 INSL4 OR4M1 ZDHHC7 GPR52 LMBRD2 ACE OR10X1 TAAR6 TAS2R5 CELSR2 P2RY4 LPAR2 MAPK7 ACKR1 GPR148	2.30e-06	1395	99	21	GO:0007186
GeneOntologyBiologicalProcess	amide metabolic process	ABCA2 SPTSSA PSEN1 SAMD8 SLC46A1 PLA2G4E ACE GBA2 PPT2 UGCG DGAT1	3.42e-05	511	99	11	GO:0043603
GeneOntologyBiologicalProcess	membrane lipid biosynthetic process	ABCA2 SPTSSA SAMD8 PGAP4 PIGV UGCG	1.11e-04	157	99	6	GO:0046467
GeneOntologyCellularComponent	vacuolar membrane	ABCA2 PSEN1 SLC2A8 ENPP1 TBC1D7 ABCC11 PLA2G4E PLEKHM1 MFSD8 M6PR	2.19e-04	507	104	10	GO:0005774
GeneOntologyCellularComponent	lysosomal membrane	ABCA2 PSEN1 SLC2A8 ENPP1 TBC1D7 PLA2G4E PLEKHM1 MFSD8 M6PR	5.00e-04	462	104	9	GO:0005765
GeneOntologyCellularComponent	lytic vacuole membrane	ABCA2 PSEN1 SLC2A8 ENPP1 TBC1D7 PLA2G4E PLEKHM1 MFSD8 M6PR	5.00e-04	462	104	9	GO:0098852
GeneOntologyCellularComponent	vacuole	ABCA2 RAMP2 PSEN1 SLC2A8 ENPP1 TBC1D7 ABCC11 PLA2G4E ACE PLEKHM1 PPT2 MFSD8 M6PR	5.98e-04	913	104	13	GO:0005773
GeneOntologyCellularComponent	lysosome	ABCA2 RAMP2 PSEN1 SLC2A8 ENPP1 TBC1D7 PLA2G4E ACE PLEKHM1 PPT2 MFSD8 M6PR	7.03e-04	811	104	12	GO:0005764
GeneOntologyCellularComponent	lytic vacuole	ABCA2 RAMP2 PSEN1 SLC2A8 ENPP1 TBC1D7 PLA2G4E ACE PLEKHM1 PPT2 MFSD8 M6PR	7.03e-04	811	104	12	GO:0000323
Domain	Sugar_transporter_CS	SLC2A8 SLC46A1 SLC22A5	7.19e-04	32	103	3	IPR005829
Domain	GPCR_Rhodpsn_7TM	DRD4 GPR18 OR4K2 OR1B1 OR4M1 GPR52 OR10X1 TAAR6 P2RY4 LPAR2 GPR148	1.17e-03	670	103	11	IPR017452
Domain	7tm_1	DRD4 GPR18 OR4K2 OR1B1 OR4M1 GPR52 OR10X1 TAAR6 P2RY4 LPAR2 GPR148	1.27e-03	677	103	11	PF00001
Domain	G_PROTEIN_RECEP_F1_1	DRD4 GPR18 OR4K2 OR1B1 OR4M1 GPR52 OR10X1 TAAR6 P2RY4 LPAR2 GPR148	1.39e-03	685	103	11	PS00237
Domain	G_PROTEIN_RECEP_F1_2	DRD4 GPR18 OR4K2 OR1B1 OR4M1 GPR52 OR10X1 TAAR6 P2RY4 LPAR2 GPR148	1.49e-03	691	103	11	PS50262
Domain	GPCR_Rhodpsn	DRD4 GPR18 OR4K2 OR1B1 OR4M1 GPR52 OR10X1 TAAR6 P2RY4 LPAR2 GPR148	1.51e-03	692	103	11	IPR000276
Domain	MBOAT_fam	MBOAT7 DGAT1	1.60e-03	11	103	2	IPR004299
Domain	MBOAT	MBOAT7 DGAT1	1.60e-03	11	103	2	PF03062
Domain	Dynein_heavy_chain_D4_dom	DNAH7 DNAH8	2.62e-03	14	103	2	IPR024317
Domain	Dynein_HC_stalk	DNAH7 DNAH8	2.62e-03	14	103	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH7 DNAH8	2.62e-03	14	103	2	IPR013602
Domain	DHC_N2	DNAH7 DNAH8	2.62e-03	14	103	2	PF08393
Domain	MT	DNAH7 DNAH8	2.62e-03	14	103	2	PF12777
Domain	AAA_8	DNAH7 DNAH8	2.62e-03	14	103	2	PF12780
Domain	MFS	SLC2A8 SLC46A1 SLC22A5 MFSD8	3.01e-03	108	103	4	PS50850
Domain	DHC_fam	DNAH7 DNAH8	3.02e-03	15	103	2	IPR026983
Domain	Dynein_heavy_dom	DNAH7 DNAH8	3.02e-03	15	103	2	IPR004273
Domain	Dynein_heavy	DNAH7 DNAH8	3.02e-03	15	103	2	PF03028
Domain	MFS_dom	SLC2A8 SLC46A1 SLC22A5 MFSD8	6.48e-03	134	103	4	IPR020846
Pathway	REACTOME_METABOLISM_OF_LIPIDS	SPTSSA MBOAT7 SAMD8 CYP51A1 PLA2G4E GBA2 ARSI LCLAT1 PPT2 MIGA2 SLC22A5 UGCG HSD3B1 M6PR DGAT1	6.99e-06	620	89	15	MM15193
Pathway	REACTOME_METABOLISM_OF_LIPIDS	SPTSSA MBOAT7 SAMD8 CYP51A1 PLA2G4E GBA2 ARSI LCLAT1 PPT2 MIGA2 SLC22A5 UGCG HSD3B1 M6PR MED13 DGAT1	1.81e-05	757	89	16	M27451
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	SPTSSA SAMD8 GBA2 ARSI UGCG M6PR	2.46e-05	92	89	6	MM15086
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	SPTSSA SAMD8 GBA2 ARSI UGCG M6PR	5.79e-05	107	89	6	M14857
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ABCA2 MBOAT7 ENPP1 CYP51A1 MANEA PGAP4 TMEM43 LMBRD2 MYORG CELSR2 METTL9 DSEL CPVL M6PR DGAT1	3.30e-06	1201	105	15	35696571
Pubmed	Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.	RRN3P2 RRN3	9.03e-06	2	105	2	12015311
Pubmed	A neuroprotective phase precedes striatal degeneration upon nucleolar stress.	RRN3P2 RRN3	9.03e-06	2	105	2	23764776
Pubmed	Identification of small subunit of serine palmitoyltransferase a as a lysophosphatidylinositol acyltransferase 1-interacting protein.	SPTSSA MBOAT7	9.03e-06	2	105	2	23510452
Pubmed	Non-motor symptoms associated with progressive loss of dopaminergic neurons in a mouse model of Parkinson's disease.	RRN3P2 RRN3	9.03e-06	2	105	2	38745938
Pubmed	Function of the growth-regulated transcription initiation factor TIF-IA in initiation complex formation at the murine ribosomal gene promoter.	RRN3P2 RRN3	9.03e-06	2	105	2	8413268
Pubmed	Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism.	RRN3P2 RRN3	9.03e-06	2	105	2	30918302
Pubmed	Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning.	RRN3P2 RRN3	9.03e-06	2	105	2	27257073
Pubmed	ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.	RRN3P2 RRN3	9.03e-06	2	105	2	12620228
Pubmed	Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases.	RRN3P2 RRN3	9.03e-06	2	105	2	31110473
Pubmed	DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.	RRN3P2 RRN3	9.03e-06	2	105	2	23393135
Pubmed	Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons.	RRN3P2 RRN3	9.03e-06	2	105	2	24273493
Pubmed	Role of PC-1 and ACE genes on insulin resistance and cardiac mass in never-treated hypertensive patients. Suggestive evidence for a digenic additive modulation.	ENPP1 ACE	9.03e-06	2	105	2	17367703
Pubmed	Characterization of vertebrate cohesin complexes and their regulation in prophase.	ANAPC1 ANAPC5 STAG2	9.50e-06	14	105	3	11076961
Pubmed	Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads.	ANAPC1 ANAPC5 STAG2	1.76e-05	17	105	3	21043528
Pubmed	The role of PC-1 and ACE genes in diabetic nephropathy in type 1 diabetic patients: evidence for a polygenic control of kidney disease progression.	ENPP1 ACE	2.70e-05	3	105	2	12147786
Pubmed	Adaptor protein Lnk binds to PDGF receptor and inhibits PDGF-dependent signaling.	SH2B3 PDGFRA	2.70e-05	3	105	2	21310211
Pubmed	ACE and PC-1 gene polymorphisms in normoalbuminuric Type 1 diabetic patients: a 10-year prospective study.	ENPP1 ACE	2.70e-05	3	105	2	12126783
Pubmed	TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation.	RRN3P2 RRN3	2.70e-05	3	105	2	19217408
Pubmed	Nucleolar stress controls mutant Huntington toxicity and monitors Huntington's disease progression.	RRN3P2 RRN3	2.70e-05	3	105	2	34880223
Pubmed	Association of PS1 1/2, ACE I/D, and LRP C/T polymorphisms with Alzheimer's disease in the Chinese population: a meta-analysis of case-control studies.	PSEN1 ACE	2.70e-05	3	105	2	25730041
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABCA2 GBF1 SH2B3 ZDHHC7 SFI1 GBA2 PLEKHM1 MYORG CELSR2 DISP2 CPVL GCN1 MED13	2.93e-05	1105	105	13	35748872
Pubmed	Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.	CNOT11 ANAPC1 ANAPC5 MED13	3.14e-05	59	105	4	28813667
Pubmed	Defining the membrane proteome of NK cells.	ABCA2 GBF1 PDGFRA MBOAT7 TMEM237 CYP51A1 LMBRD2 PRPF40A LCLAT1 GCN1 M6PR STAG2 MED13	5.17e-05	1168	105	13	19946888
Pubmed	Human genetics of diabetic nephropathy.	ENPP1 ACE	5.40e-05	4	105	2	25594612
Pubmed	Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase.	PAK6 MAP2K6	5.40e-05	4	105	2	15550393
Pubmed	Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA.	RRN3P2 RRN3	5.40e-05	4	105	2	24297901
Pubmed	Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models.	RRN3P2 RRN3	5.40e-05	4	105	2	28360124
Pubmed	The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome.	ANAPC1 ANAPC5	8.97e-05	5	105	2	17827148
Pubmed	Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I.	RRN3P2 RRN3	8.97e-05	5	105	2	18559419
Pubmed	The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis.	RRN3P2 RRN3	8.97e-05	5	105	2	15805466
Pubmed	Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice.	RRN3P2 RRN3	8.97e-05	5	105	2	19036968
Pubmed	The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.	ANAPC1 ANAPC5	8.97e-05	5	105	2	19826416
Pubmed	Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling.	RRN3P2 RRN3	8.97e-05	5	105	2	21228155
Pubmed	Initiation of steroidogenesis precedes expression of cholesterologenic enzymes in the fetal mouse testes.	CYP51A1 HSD3B1	8.97e-05	5	105	2	19793088
Pubmed	Genetic variations associated with diabetic nephropathy and type II diabetes in a Japanese population.	ACE SLC12A3	1.34e-04	6	105	2	17653210
Pubmed	Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals.	GBA2 UGCG	1.34e-04	6	105	2	28373486
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	TRIP12 PRPF40A ANAPC1 GCN1 STAG2 MED13	1.82e-04	272	105	6	31010829
Pubmed	A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription.	RRN3P2 RRN3	1.88e-04	7	105	2	28715449
Pubmed	Nuclear actin and myosin I are required for RNA polymerase I transcription.	RRN3P2 RRN3	1.88e-04	7	105	2	15558034
Pubmed	Murine AGM single-cell profiling identifies a continuum of hemogenic endothelium differentiation marked by ACE.	PDGFRA ACE	1.88e-04	7	105	2	34517413
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	TRIP12 INTS14 ANAPC1 BOP1 ANAPC5 STAG2 KIF22	1.99e-04	394	105	7	27248496
Pubmed	Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.	ANAPC1 ANAPC5	2.50e-04	8	105	2	20686030
Pubmed	Expression and functional role of hepatocyte growth factor and its receptor (c-met) during fetal mouse testis development.	INSL4 HSD3B1	2.50e-04	8	105	2	17170214
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	GBF1 MBOAT7 TMEM237 SLC39A11 CYP51A1 TMEM43 DCLRE1B PRPF40A LCLAT1 ANAPC1 RRN3 M6PR	2.81e-04	1203	105	12	29180619
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	GBF1 TRIP12 ANAPC1 ANAPC5	3.08e-04	106	105	4	31024071
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	MBOAT7 INSL4 PGAP4 TMEM43 LMBRD2 TRIM27 LCLAT1 FLAD1 MFSD8	3.38e-04	719	105	9	35337019
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	GBF1 TMEM237 SAMD8 SLC46A1 LMBRD2 PRPF40A LCLAT1 CELSR2 SLC22A5 UGCG MFSD8	3.69e-04	1061	105	11	33845483
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	GBF1 TRIP12 ANAPC1 MROH7 GCN1	3.79e-04	202	105	5	33005030
Pubmed	Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons.	ANAPC1 ANAPC5	4.00e-04	10	105	2	10500174
Pubmed	Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.	ANAPC1 ANAPC5	4.00e-04	10	105	2	10318877
Pubmed	Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.	ANAPC1 MAP2K6	4.00e-04	10	105	2	14744933
Pubmed	Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population.	ACE SLC12A3	4.88e-04	11	105	2	19779464
Pubmed	Poor replication of candidate genes for major depressive disorder using genome-wide association data.	DRD4 ACE M6PR	5.01e-04	51	105	3	20351714
Pubmed	Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis.	RRN3P2 RRN3	5.84e-04	12	105	2	15989966
Pubmed	Congenital hydrocephalus in genetically engineered mice.	MBOAT7 CELSR2	5.84e-04	12	105	2	21746835
Pubmed	Mitotic regulation of the human anaphase-promoting complex by phosphorylation.	ANAPC1 ANAPC5	5.84e-04	12	105	2	14657031
Pubmed	Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.	ANAPC1 ANAPC5	5.84e-04	12	105	2	16364912
Pubmed	Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.	PPT2 RRN3 SLC22A5	5.93e-04	54	105	3	24823311
Pubmed	The DNA sequence and analysis of human chromosome 6.	ENPP1 MANEA TRIM27 TAAR6 ADGB FBXO9 PPT2 DNAH8	6.10e-04	622	105	8	14574404
Pubmed	The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20.	ANAPC1 ANAPC5	6.89e-04	13	105	2	23979597
Pubmed	Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.	ANAPC1 ANAPC5	6.89e-04	13	105	2	16921029
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH7 DNAH8	8.02e-04	14	105	2	9373155
Pubmed	Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway.	ANAPC1 ANAPC5	8.02e-04	14	105	2	29183995
Pubmed	Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease.	PSEN1 ACE	9.24e-04	15	105	2	11436125
Pubmed	Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription.	ANAPC1 ANAPC5	9.24e-04	15	105	2	35440621
Pubmed	Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice.	CELSR2 HSD3B1	9.24e-04	15	105	2	35306493
Pubmed	The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex.	ANAPC1 ANAPC5	9.24e-04	15	105	2	10922056
Pubmed	APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.	ANAPC1 ANAPC5	9.24e-04	15	105	2	23007861
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	SLC39A11 ABCC11 TMEM43 MS4A10 RRN3 AADACL2 UGCG MAPK7 HS6ST3	9.56e-04	832	105	9	36724073
Pubmed	Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex.	ANAPC1 ANAPC5	1.05e-03	16	105	2	10548110
Pubmed	No replication of genetic association between candidate polymorphisms and Alzheimer's disease.	PSEN1 ACE	1.05e-03	16	105	2	19889475
Pubmed	Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese.	PSEN1 ACE	1.05e-03	16	105	2	20880607
Pubmed	Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.	ANAPC1 ANAPC5	1.05e-03	16	105	2	25306923
Pubmed	The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.	ACE SLC12A3	1.05e-03	16	105	2	15824464
Pubmed	The anaphase-promoting complex: a key factor in the regulation of cell cycle.	ANAPC1 ANAPC5	1.05e-03	16	105	2	15678131
Pubmed	Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma.	TRIM27 ANAPC1 ANAPC5	1.11e-03	67	105	3	29863498
Pubmed	Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis.	ANAPC1 ANAPC5	1.19e-03	17	105	2	23160376
Pubmed	A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression.	ANAPC1 ANAPC5	1.19e-03	17	105	2	11340163
Pubmed	TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.	ANAPC1 ANAPC5	1.19e-03	17	105	2	12956947
Pubmed	Mechanism of APC/CCDC20 activation by mitotic phosphorylation.	ANAPC1 ANAPC5	1.19e-03	17	105	2	27114510
Pubmed	Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.	ANAPC1 ANAPC5	1.19e-03	17	105	2	12070128
Pubmed	Atomic structure of the APC/C and its mechanism of protein ubiquitination.	ANAPC1 ANAPC5	1.19e-03	17	105	2	26083744
Pubmed	Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.	ANAPC1 ANAPC5	1.19e-03	17	105	2	29033132
Pubmed	Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS.	ACE SLC12A3	1.19e-03	17	105	2	21082674
Pubmed	Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C).	ANAPC1 ANAPC5	1.19e-03	17	105	2	23078409
Pubmed	A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.	SH2B3 CELSR2	1.34e-03	18	105	2	20971364
Pubmed	Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2.	ANAPC1 ANAPC5	1.34e-03	18	105	2	11535616
Pubmed	BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner.	ANAPC1 ANAPC5	1.34e-03	18	105	2	22193957
Pubmed	Mitotic regulation of the APC activator proteins CDC20 and CDH1.	ANAPC1 ANAPC5	1.34e-03	18	105	2	10793135
Pubmed	The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit.	ANAPC1 ANAPC5	1.34e-03	18	105	2	14593737
Pubmed	HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.	PDGFRA ACE	1.49e-03	19	105	2	31345929
Pubmed	Molecular mechanism of APC/C activation by mitotic phosphorylation.	ANAPC1 ANAPC5	1.49e-03	19	105	2	27120157
Pubmed	Molecular architecture and mechanism of the anaphase-promoting complex.	ANAPC1 ANAPC5	1.49e-03	19	105	2	25043029
Pubmed	Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.	ANAPC1 ANAPC5	1.49e-03	19	105	2	25490258
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CNOT11 GBF1 TRIM27 TRIP12 ANAPC1 RRN3 BOP1 GCN1	1.61e-03	724	105	8	36232890
Pubmed	APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box.	ANAPC1 ANAPC5	1.66e-03	20	105	2	11742988
Pubmed	Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin.	MANEA GBA2	1.66e-03	20	105	2	12560567
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	GBF1 MBOAT7 TMEM237 CYP51A1 CHML GBA2 GCN1	1.71e-03	568	105	7	37774976
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	CYP51A1 ANAPC1 FLAD1 BOP1 CPVL ANAPC5 GCN1	1.77e-03	571	105	7	37167062
ToppCell	10x5'v1-week_17-19-Myeloid_DC-DC-DC1\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ENPP1 ACE ADGB WDR97 CPVL CNGA4	2.88e-06	169	104	6	488ba50631a64cb9e0d69219491c66ac824c9e7d
ToppCell	metastatic_Brain-Endothelial_cells-Stalk-like_ECs\|Endothelial_cells / Location, Cell class and cell subclass	SAMD8 SLC46A1 CHML URGCP DISP2 LPAR2	3.52e-06	175	104	6	f6a6db992e803d36c866a91706b02f67e0fd3e09
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RAMP2 RNF144A ACE RASGRP3 CPVL DNAH8	3.63e-06	176	104	6	269326c2bf44a9003d95bc6dbc839f08f25737ca
ToppCell	tumor_Lung-Myeloid_cells-pDCs\|tumor_Lung / Location, Cell class and cell subclass	DRD4 SH2B3 CHML SLC12A3 CSF2RB UGCG	4.27e-06	181	104	6	c864ffeb9234b8c29754afc91c85a972889617f4
ToppCell	E18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_A\|E18.5-samps / Age Group, Lineage, Cell class and subclass	RAMP2 PCDH12 ACE RASGRP3 DNAH8 KIF22	4.41e-06	182	104	6	ea4f6c8f600ffe9f8e0609637b3371a5ac48ca03
ToppCell	droplet-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RAMP2 RNF144A ACE RASGRP3 DISP2 DNAH8	5.99e-06	192	104	6	6b69bb8fab9b470850eba1a070a500435ec233cd
ToppCell	MS-Multiple_Sclerosis-Myeloid-pDC\|Multiple_Sclerosis / Disease, condition lineage and cell class	DRD4 SLC2A8 SLC12A3 CSF2RB UGCG MAP2K6	7.35e-06	199	104	6	c10c8c9322cad4996e4aa11a8680e3d781644ace
ToppCell	Endothelial-F\|World / shred on cell class and cell subclass (v4)	RAMP2 RNF144A ACE RASGRP3 DNAH8	1.88e-05	139	104	5	32d3c5d35e6c4205711c3500d736fd108443e6b4
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ENPP1 GBA2 MIGA2 MROH7 MIEF1	3.70e-05	160	104	5	8374ae912337947b2cc8d17d5840f306361fe1ff
ToppCell	Children_(3_yrs)-Immune-dendritic_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ENPP1 SLC12A3 CSF2RB UGCG MAP2K6	3.92e-05	162	104	5	86a0b9dabd150dc993bfc0f3344804de7f8e4042
ToppCell	Fetal_29-31_weeks-Immune-dendritic_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SH2B3 ENPP1 SLC12A3 CSF2RB CPVL	4.28e-05	165	104	5	d8b0a9b6f704b98e8f0412c11739879a26c036e2
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPR18 SLC39A11 FLAD1 BOP1 DGAT1	4.67e-05	168	104	5	cc0dd43d5cda01e643d8e8d74ec7617d61890760
ToppCell	(3)_DC_plasmacytoid\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	DRD4 CHML SLC12A3 CSF2RB UGCG	4.67e-05	168	104	5	8a913db9b2a1a4ff96fb139734a3834e6aa263f1
ToppCell	Immune-dendritic_cell\|World / Lineage, Cell type, age group and donor	ENPP1 SLC12A3 CSF2RB UGCG CPVL	5.08e-05	171	104	5	6a9e2e2d3e1d8cc475bf9765129bc4a32da3b8ea
ToppCell	metastatic_Lymph_Node-Myeloid_cells-pDCs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	5.08e-05	171	104	5	1f8e66073088fc1969782e443bf00f8c1877ea91
ToppCell	Children_(3_yrs)-Immune-dendritic_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ENPP1 SLC12A3 CSF2RB UGCG CPVL	5.08e-05	171	104	5	6a5ac0f56bd7b4543be103100fb735ca6bc5b8bf
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENPP1 TBC1D7 MANEA MAP3K10 MFSD8	5.82e-05	176	104	5	2e9073166da4d9fae70ba4f3fdcad35523caf7cd
ToppCell	normal_Lung-Endothelial_cells-EPCs\|normal_Lung / Location, Cell class and cell subclass	RAMP2 PCDH12 ACE SRL ACKR1	5.82e-05	176	104	5	71d1bd425772d89d8c550b909e0ec0e36ff22a7e
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DRD4 SH2B3 SLC12A3 CSF2RB UGCG	5.98e-05	177	104	5	8887ff6341eb070bdaa890cc2cd7745f0cf1b0af
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DRD4 SH2B3 SLC12A3 CSF2RB UGCG	5.98e-05	177	104	5	507f06d31ab773099c9431b6f433899dc97b5566
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_8\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CNOT11 LCLAT1 TMEM229B RASGRP3 MAP3K10	6.30e-05	179	104	5	0624dd537a68736f4d7b8b4de2c56168ed0e60a9
ToppCell	P15-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RAMP2 RNF144A ACE RASGRP3 DNAH8	6.47e-05	180	104	5	410ea13a9c00cf54b4d47c72404dfe893c086d87
ToppCell	Severe-Lymphoid-pDC\|Severe / Condition, Lineage, Cell class and cell subclass	DRD4 PDE7A SLC12A3 UGCG MAP2K6	6.64e-05	181	104	5	2caecb7c5dcdad46fd02b4ffb73cb613ce835187
ToppCell	Severe-Lymphoid-pDC-\|Severe / Condition, Lineage, Cell class and cell subclass	DRD4 PDE7A SLC12A3 UGCG MAP2K6	6.64e-05	181	104	5	277ce4c49121da0990a5933b19d2c6af9bbe253e
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	LMBRD2 TRIP12 FBXO9 UGCG DGAT1	6.82e-05	182	104	5	21744c9c792e57d5d41b25986f419b2358c7057b
ToppCell	Cerebellum-Macroglia\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SLC39A11 CYP51A1 MYORG SLC22A5 MFSD8	7.18e-05	184	104	5	91b047a01d2cad231308279ca37fa699630f7864
ToppCell	droplet-Pancreas-Endocrine-18m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAMP2 SH2B3 RNF144A ACE RASGRP3	7.37e-05	185	104	5	512a195ebbae445afe3722a3943020080daf2f3c
ToppCell	ICU-NoSEP-Myeloid-pDC\|ICU-NoSEP / Disease, Lineage and Cell Type	DRD4 SLC2A8 SLC12A3 UGCG MAP2K6	7.37e-05	185	104	5	7564a47df4a4e3af30d40aa0f48bd9d9c82358ae
ToppCell	Multiple_Sclerosis-Myeloid-pDC\|Multiple_Sclerosis / Disease, Lineage and Cell Type	DRD4 SLC2A8 SLC12A3 CSF2RB UGCG	7.56e-05	186	104	5	330a4f669adea91ff9f2dff2de2210f5e3401e19
ToppCell	tumor_Lung-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	DRD4 CHML SLC12A3 CSF2RB UGCG	7.56e-05	186	104	5	3d7c1a281fb82db4471283f39937007d889a5f38
ToppCell	(2)_Fibroblasts-(20)_Fibro-1\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	RAMP2 PDGFRA ACE ARSI ACKR1	7.56e-05	186	104	5	e93415b59dd89bc8a966dab0e0b65fe215933598
ToppCell	368C-Myeloid-Dendritic-cDC_proliferating_1\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	GPR18 TMEM237 PPT2 MIEF1 GCN1	7.56e-05	186	104	5	5cadab3271fce9ab6da3d7ba9827b8a221cac166
ToppCell	IIH-pDC-\|IIH / Condition, Cell_class and T cell subcluster	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	7.75e-05	187	104	5	ad87b146ea8dd9f695e722f8f0e8e1057c7f3167
ToppCell	E17.5-Endothelial-capillary_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RAMP2 PCDH12 ACE RASGRP3 DNAH8	7.75e-05	187	104	5	61b8a53f29bb8b33c69f680b8359a1143a23999d
ToppCell	IIH-pDC\|IIH / Condition, Cell_class and T cell subcluster	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	7.75e-05	187	104	5	5e59e9153a18bcfb5c8dc94599080216661de7ce
ToppCell	Mild_COVID-19-Myeloid-pDC\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	DRD4 PDE7A SLC12A3 UGCG MAP2K6	7.75e-05	187	104	5	99c3c4a7b9179dce7982dc6516d561c952abc80e
ToppCell	LAM-Lymphoid-pDC\|Lymphoid / Condition, Lineage and Cell class	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	7.75e-05	187	104	5	4d9ffd2bbdf1c9869e28991ce9331e4ccf3c0166
ToppCell	3'_v3-blood-Myeloid_Dendritic\|blood / Manually curated celltypes from each tissue	SH2B3 SLC12A3 CSF2RB UGCG CPVL	7.95e-05	188	104	5	239a2162a21d3339da7c1884ab76286346fbf97f
ToppCell	PBMC-Mild-Myeloid-pDC-pDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	7.95e-05	188	104	5	89411c4db3df5e1dc36cf8af4ffcc0abbecbe4df
ToppCell	PBMC-Mild-Myeloid-pDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	7.95e-05	188	104	5	de6a270b6e4fe09c39a52c296632d86ada98465b
ToppCell	PBMC-Mild-Myeloid-pDC-pDC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	7.95e-05	188	104	5	879054b780378ae05be68e597c77c931bf0ade03
ToppCell	PBMC-Mild-Myeloid-pDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	8.15e-05	189	104	5	209cae68d78c8f72479b169e27c3ff7e143adece
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Dendritic-pDC\|lymph-node_spleen / Manually curated celltypes from each tissue	DRD4 ARSI SLC12A3 CSF2RB UGCG	8.15e-05	189	104	5	6c2ace61a7d62bcf7e76b73e2da8b722d03e713b
ToppCell	facs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RAMP2 RNF144A ACE RASGRP3 DNAH8	8.15e-05	189	104	5	16e019fd6e2376110b767739754389891f391669
ToppCell	PBMC-Mild-Myeloid-pDC-pDC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	8.15e-05	189	104	5	a9ad1fb12304541f909dd0eeac9b9eb28c31fd41
ToppCell	COVID-19_Mild-Myeloid-pDC\|COVID-19_Mild / Disease group, lineage and cell class	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	8.15e-05	189	104	5	c6cfd6aa21c19f2c62d80218bbc924e14e82aada
ToppCell	PBMC-Mild-Myeloid-pDC-pDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	8.15e-05	189	104	5	98ca646231fbd5f29827c2dd31ac4503026bad7d
ToppCell	MS-pDC-\|MS / Condition, Cell_class and T cell subcluster	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	8.35e-05	190	104	5	f56ec302d556ace4f7609017a35c311cf43aa8a5
ToppCell	MS-pDC\|MS / Condition, Cell_class and T cell subcluster	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	8.35e-05	190	104	5	f41d7ab7d7fbcd73fddb6c3533c6a3e642e3d07f
ToppCell	COVID-19_Moderate-pDC\|World / disease group, cell group and cell class	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	8.56e-05	191	104	5	93adfbc0b22f6006d6d5ad67a99e33cbe9e1dfe9
ToppCell	COVID-19_Moderate-pDC\|COVID-19_Moderate / disease group, cell group and cell class	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	8.56e-05	191	104	5	9d0ffa65c547e20b4076fd97776d7738cbd453ec
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RAMP2 PCDH12 ACE RASGRP3 DNAH8	8.77e-05	192	104	5	e4dd24aefdf13cd4206714f02fde2288f3173ffc
ToppCell	droplet-Lung-nan-3m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAMP2 RNF144A ACE RASGRP3 DNAH8	8.99e-05	193	104	5	7cff1e859b296b1032eebcfc0f99a504f3bda2c9
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RAMP2 RNF144A ACE RASGRP3 DNAH8	8.99e-05	193	104	5	b7c0b4dbbe11f86cff6371d3d12a6b772b938d78
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RAMP2 RNF144A ACE RASGRP3 DNAH8	8.99e-05	193	104	5	e44d777f65b907f299cefd73296805ac4c92d383
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RAMP2 RNF144A PCDH12 ACE RASGRP3	8.99e-05	193	104	5	097a244cf37ce6c1ace9bae56beb7de59442cd6b
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	9.21e-05	194	104	5	3f9e4a8e5699bc379e8a0d337e0daef09632e71c
ToppCell	droplet-Lung-1m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RAMP2 RNF144A ACE RASGRP3 DNAH8	9.21e-05	194	104	5	1ac52b00ea0b0ddbd04f5d85fa8c086980a78926
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic\|bone_marrow / Manually curated celltypes from each tissue	ENPP1 SLC12A3 CSF2RB UGCG CPVL	9.21e-05	194	104	5	768271ae45ff9f6aa3cd9b0ed15fa3caaa68a7b0
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-pDC-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	9.44e-05	195	104	5	06051de72b5c1e0d483a28b14dabd247dfca0ed9
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-pDC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	9.44e-05	195	104	5	3aa44633c72658545aa2b35bf9d532c62f36a451
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Dendritic_cell-DC_1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ENPP1 MANEA PGAP4 CSF2RB CPVL	9.67e-05	196	104	5	53d1f9e9f009d1417a19ca6f9a83ecdf7776ef88
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DRD4 SLC12A3 CSF2RB UGCG CPVL	9.67e-05	196	104	5	fe7410c639fe4d7df3f6dcdb058b9a38b712927e
ToppCell	ILEUM-non-inflamed-(7)_Endothelial_cell-(7)_ACKR1+_endothelial_cells\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CSF2RB UGCG ACKR1 CPVL KIF22	9.90e-05	197	104	5	143607d195c8aa2b94d995af0b2ef38582565611
ToppCell	Biopsy_Other_PF-Immune-pDCs\|Biopsy_Other_PF / Sample group, Lineage and Cell type	DRD4 CHML SLC12A3 UGCG MAP2K6	9.90e-05	197	104	5	598a130eb7afb1bb95da64a964218362627feb49
ToppCell	18-Airway-Endothelial-Endothelial\|Airway / Age, Tissue, Lineage and Cell class	RAMP2 PCDH12 ACE RASGRP3 ACKR1	1.01e-04	198	104	5	70d3ea0837dd6ad62abdf349e566a2e62c8e345a
ToppCell	Sepsis-Int-URO-Others-RBC\|Int-URO / Disease, condition lineage and cell class	ACE SLC12A3 UGCG DISP2 DSEL	1.01e-04	198	104	5	29203aaa5c1844f72289e03f585cd5e7fc498a9a
ToppCell	Sepsis-Int-URO-Others\|Int-URO / Disease, condition lineage and cell class	ACE SLC12A3 UGCG DISP2 DSEL	1.01e-04	198	104	5	67f721ea8e60042317ba12efd584f56b07cfb29d
ToppCell	18-Airway-Endothelial\|Airway / Age, Tissue, Lineage and Cell class	RAMP2 PCDH12 ACE RASGRP3 ACKR1	1.01e-04	198	104	5	6b7f1b352dc3a803af87106ffb63944bd4286dfe
ToppCell	droplet-Tongue-nan-24m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA2 ENPP1 SLC46A1 TMEM229B	1.04e-04	104	104	4	a4ae3cae44aac8b6e0d14896f9acab44f0cc97c4
ToppCell	MS-IIF-Myeloid-pDC\|IIF / Disease, condition lineage and cell class	DRD4 SLC2A8 SLC12A3 UGCG MAP2K6	1.04e-04	199	104	5	e262ee854e64d87460bee810c14d6cbe744460e8
ToppCell	Sepsis-ICU-NoSEP-Myeloid-pDC\|ICU-NoSEP / Disease, condition lineage and cell class	DRD4 SLC2A8 SLC12A3 UGCG MAP2K6	1.04e-04	199	104	5	a199e67438eeed903d0996605591ec54400fdd66
ToppCell	COVID-19-COVID-19_Mild-Myeloid-pDC\|COVID-19_Mild / Disease, condition lineage and cell class	DRD4 SLC12A3 CSF2RB UGCG MAP2K6	1.04e-04	199	104	5	9de61e5189d907cc969ac3043d68204f70acc0bf
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	RAMP2 SH2B3 ACE UGCG ACKR1	1.06e-04	200	104	5	2d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCell	Control-Mast_cells-Dendritic_cells\|Control / group, cell type (main and fine annotations)	TMEM169 RNF144A MAP2K6 CNGA4	2.99e-04	137	104	4	9906225a2eb1a891e5bfbb00929bc041f325b376
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	OR4K2 PDGFRA INSL4 PAK6	3.33e-04	141	104	4	3fa3d2a8ebd9c285168ecea6db9cad74d3a3e85a
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	OR4K2 PDGFRA INSL4 PAK6	3.33e-04	141	104	4	cabb5b8c0874813c713508af2ac620ab0d61ab6f
ToppCell	tumor_Lung-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	ENPP1 SLC22A5 FER1L5 CPVL	3.80e-04	146	104	4	8b2d104fdb0fdb09410450c6c651e1edb00cae44
ToppCell	LA-15._Ventricular_Cardiomyocyte_III\|LA / Chamber and Cluster_Paper	TMEM169 PAK6 SRL DISP2	3.90e-04	147	104	4	8970eb6b82589f39439c61a57d999661ec8342de
ToppCell	343B-Myeloid-Dendritic-cDC1\|343B / Donor, Lineage, Cell class and subclass (all cells)	SH2B3 ENPP1 TMEM229B CPVL	4.00e-04	148	104	4	e44cdc1c3f3314c549a0afa9298c8568022b9d8b
ToppCell	Fetal_29-31_weeks-Immune-dendritic_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SH2B3 ENPP1 SLC12A3 MAP2K6	4.21e-04	150	104	4	57f21ad380fd1350a2c25d75ad8c3b763ded53ec
ToppCell	Transverse-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	GPR18 ENPP1 MAP2K6 CPVL	4.32e-04	151	104	4	6870f3b5d2bfad849c3203658b5f28f0ae181295
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-valve_cells\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENPP1 GPR52 CTXN3 HS6ST3	4.54e-04	153	104	4	1440f2716fea74e2c3eb2924eba3d63ebd08c997
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial-Matrix_Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	RAMP2 PCDH12 RASGRP3 ACKR1	4.65e-04	154	104	4	928f49839b046b90c2f942458f3e365ddc4e0bc9
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	CHML PPT2 SLC12A3 UGCG	4.88e-04	156	104	4	19472ef1642c2ad333aa3ce3675a25c6ab1d4556
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN2(Gad1Gad2)-Sema3e-Inhibitory_Neuron.Gad1Gad2.Sema3e-Kcng4_(GABAergic,_K_Channel_State,_Sema3e+_SN/VTA_(SNr))-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DRD4 CTXN3 HSD3B1	4.94e-04	66	104	3	d5e878ffc0b942a35391c7dd73b30cec59f21b39
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN2(Gad1Gad2)-Sema3e-Inhibitory_Neuron.Gad1Gad2.Sema3e-Kcng4_(GABAergic,_K_Channel_State,_Sema3e+_SN/VTA_(SNr))\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DRD4 CTXN3 HSD3B1	4.94e-04	66	104	3	fdb695bbda639112c2f7b714adb7501aef4be19e
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN2(Gad1Gad2)-Sema3e\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DRD4 CTXN3 HSD3B1	4.94e-04	66	104	3	de909119de42711b6580274b1200c0e1c6ad2f55
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GPR18 TMEM229B RASGRP3 SRL	5.00e-04	157	104	4	29622bac6b16bb39cec4319bf4c4f92d33345e8a
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-plasmacytoid_dendritic_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR18 TMEM229B SLC12A3 SRL	5.00e-04	157	104	4	fc127e7720649e746f3d3f5c2e9e63784767106a
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-plasmacytoid_dendritic_cells\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR18 TMEM229B SLC12A3 SRL	5.00e-04	157	104	4	66a191cef4aa00811bb04462310d012610006f85
ToppCell	367C-Myeloid-Macrophage-SPP1+_Macrophage_3\|367C / Donor, Lineage, Cell class and subclass (all cells)	SLC39A11 RASGRP3 UGCG BOP1	5.12e-04	158	104	4	0559cc032d0b518bb9e55aa3495f5573bd8e87dd
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages-T-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MBOAT7 TMEM229B MAPK7 CPVL	5.12e-04	158	104	4	91d8c93af328c3bbebe1d8f019b94849ebc548c0
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	CHML SLC12A3 CSF2RB UGCG	5.12e-04	158	104	4	2af7beb48272e5368d9ba6b80f08d47ab8556c08
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRA PIGV CELSR2 ACKR1	5.25e-04	159	104	4	330ecbba97d47bc818a5e8d1d84b05d056bd831e
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ABCA2 TMEM229B RRN3 KIF22	5.25e-04	159	104	4	f7bccfeffa737f151417bf52ea45111b0957bce9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRA PIGV CELSR2 ACKR1	5.25e-04	159	104	4	cbb331eb689d8cea9e1146ba85e0a05d23301c47
ToppCell	COVID_non-vent-Lymphocytic-Dendritic-pDC\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	DRD4 SLC12A3 UGCG ACKR1	5.37e-04	160	104	4	61f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCell	COVID_non-vent-Lymphocytic-Dendritic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	DRD4 SLC12A3 UGCG ACKR1	5.37e-04	160	104	4	34b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCell	LAM-Lymphoid-pDC\|LAM / Condition, Lineage and Cell class	DRD4 SLC12A3 UGCG MAP2K6	5.50e-04	161	104	4	bb5b44713e4da4406cdaa79dcf2aa9f97e3cf75a
Disease	Pick's disease (is_implicated_in)	PSEN1 MAP2K6	3.27e-05	3	98	2	DOID:11870 (is_implicated_in)
Disease	CXCL11 measurement	SH2B3 ACKR1	1.08e-04	5	98	2	EFO_0010779
Disease	Parkinson's disease (implicated_via_orthology)	RRN3P2 PAK6 FBXO9 RRN3 MAP2K6	1.82e-04	157	98	5	DOID:14330 (implicated_via_orthology)
Disease	Paranoia	MANEA DNAH8	5.89e-04	11	98	2	C1456784
Disease	hypertension (is_implicated_in)	RAMP2 ACE RASGRP3 HSD3B1	7.22e-04	121	98	4	DOID:10763 (is_implicated_in)
Disease	leukemia (is_implicated_in)	PDGFRA ACE	8.32e-04	13	98	2	DOID:1240 (is_implicated_in)
Disease	Alzheimer's disease (implicated_via_orthology)	PSEN1 CYP51A1 ACE	9.13e-04	57	98	3	DOID:10652 (implicated_via_orthology)
Disease	C-X-C motif chemokine 11 measurement	SH2B3 ACKR1	9.68e-04	14	98	2	EFO_0008057
Disease	renal fibrosis (implicated_via_orthology)	GPR52 ACE	1.44e-03	17	98	2	DOID:0050855 (implicated_via_orthology)
Disease	cardiomyopathy (is_implicated_in)	SLC22A5 DGAT1	1.80e-03	19	98	2	DOID:0050700 (is_implicated_in)
Disease	hydrocephalus (implicated_via_orthology)	MBOAT7 CELSR2	1.80e-03	19	98	2	DOID:10908 (implicated_via_orthology)
Disease	Alcoholic Intoxication, Chronic	DRD4 SLC46A1 PCDH12 ACE ANAPC1	2.03e-03	268	98	5	C0001973
Disease	triacylglycerol 58:9 measurement	GBF1 SLC39A11	2.42e-03	22	98	2	EFO_0010443
Disease	leptin measurement	ADGB CPVL DNAH8	2.51e-03	81	98	3	EFO_0005000
Disease	CCL11 measurement	SRL ACKR1	2.64e-03	23	98	2	EFO_0005188
Disease	Depressive disorder	DRD4 PSEN1 ACE TAAR6 M6PR	2.82e-03	289	98	5	C0011581
Disease	Attention deficit hyperactivity disorder	DRD4 MED13	2.87e-03	24	98	2	C1263846
Disease	Dystonia	PSEN1 SLC46A1 MYORG	2.98e-03	86	98	3	C0013421
Disease	Cardiac Arrhythmia	ACE SLC22A5	3.12e-03	25	98	2	C0003811

Protein segments in the cluster

Peptide	Gene	Start	Entry
WFDLDLSTKPYRMLR	BOP1	646	Q14137
SLYFTKDEALPWAMR	AADACL2	251	Q6P093
ILLDPYRSMPTSTWA	CTXN3	51	Q4LDR2
LASSRSYAMLLFAWE	ACE	176	P12821
AMLSYFKPLLDWLRT	ACE	1196	P12821
FPLSLMYWIGFLLEI	HSD3B1	286	P14060
LPATTYEFELWPMLL	ADGB	226	Q8N7X0
SRALMHITDWYPTLV	ARSI	341	Q5FYB1
WIMTLTTTTPLLLLY	GPR18	146	Q14330
PRWLYSLYDAETLMD	CRBN	241	Q96SW2
SSTVLFMLFRPLFRW	ACKR1	76	Q16570
SLPISQPWYLSLMFR	CELSR2	1631	Q9HCU4
EYLVSVPLRMFRLWA	DGAT1	416	O75907
YMSSSSRKPSLLWLL	DCLRE1B	326	Q9H816
ASLMDIYLDRLATPW	DISP2	446	A7MBM2
KTLLRCSYFMAWELP	MROH7	1151	Q68CQ1
PRLLWALYFNMRDSS	CHML	546	P26374
WAMISRPYSTLRDCL	RAMP2	86	O60895
WRSIRILYLTMFLSS	MFSD8	36	Q8NHS3
AWMARLSLPLTTNYR	PCDH12	1056	Q9NPG4
YWRSSSPTIALPMLL	ANAPC5	591	Q9UJX4
RSIADWLRAPDTMYL	ANAPC1	1381	Q9H1A4
WMAPESIFDNLYTTL	PDGFRA	861	P16234
YVATRWYRAPELMLS	MAPK7	221	Q13164
WYRAPELMLSLHEYT	MAPK7	226	Q13164
ISWDSRLHSPMYYLL	OR1B1	51	Q8NGR6
WVDRSLHTPMYLFLS	OR10X1	66	Q8NGY0
PFWLALALLIAMTLY	SLC46A1	211	Q96NT5
YWMAPEVISRSLYAT	PAK6	566	Q9NQU5
SQPRILLYSSTLRWM	KIAA0100	1271	Q14667
TYAWMAPEVIRLSLF	MAP3K10	266	Q02779
SRMAPLLSRSYLAVW	LPAR2	176	Q9HBW0
KLLSILYWTLFSPAM	LCLAT1	346	Q6UWP7
RDRDFPWTTTLSMLY	CPVL	136	Q9H3G5
FIYMWPLSSFLTDKI	OR4K2	256	Q8NGD2
IWYSSITAPKMLIDF	OR4M1	71	Q8NGD0
RPWALSVTMSYLEIY	KIF22	166	Q14807
FMTYLVEPLFTEWAR	PDE7A	416	Q13946
MVYISSSALSWRPIL	DNAH8	2261	Q96JB1
LFLESPFESPIWRMY	MS4A10	146	Q96PG2
LFSYLTVSWLTPLMI	ABCC11	91	Q96J66
APARSYVLRSAWTML	MBOAT7	336	Q96N66
MWTLRSPLTRSLYVN	METTL9	21	Q9H1A3
EMLSYALRPETWATT	MIGA2	401	Q7L4E1
DILMPLWTSYTVDRN	ENPP1	686	P22413
LLPWLMETLTYEQSS	GCN1	1696	Q92616
LLGPLLTWIYMRFAS	PGAP4	271	Q9BRR3
MASLFRSYLPAIWLL	INSL4	1	Q14641
MAPWSREAVLSLYRA	MIEF1	1	L0R8F8
MLWLPYIIYFLLESS	GPR52	276	Q9Y2T5
PLMLLLYWATFRGLQ	DRD4	206	P21917
ITMLRDPVSRYLSEW	HS6ST3	241	Q8IZP7
MRSASIGVLALSWYP	MANEA	176	Q5SRI9
MTTTRYRPTWDLALD	RNF144A	1	P50876
SSWMELYPTISSDIR	PRPF40A	631	O75400
IFRLRPWDATATYMF	P2RY4	61	P51582
TDYLKWLFPTSMRSN	PPT2	146	Q9UMR5
WLFPTSMRSNLYRIC	PPT2	151	Q9UMR5
LSGATWTMATLYRDP	PLA2G4E	411	Q3MJ16
SMALPALEPSTRYWA	CSF2RB	396	P32927
SALEMLENSLYSPTW	DOK1	136	Q99704
MFRPLSQSLYWLLAA	MT-CYB	316	P00156
VFRSLAYMRPLSIWA	GBA2	871	Q9HCG7
LMYIFRWVVSSDLDL	FBXO9	196	Q9UK97
DLRVPSSMLYWLFLP	GPR148	41	Q8TDV2
SSMLYWLFLPSSLLA	GPR148	46	Q8TDV2
FSSLWELMVPFTRDY	INTS14	56	Q96SY0
KTIWSTMLRLYEFDL	CYP51A1	466	Q16850
TWLYLEPIFSSPDIM	DNAH7	986	Q8WXX0
LSLFLLYGWSITPIM	ABCA2	1876	Q9BZC7
RESMTIYIFLSALWD	UGCG	356	Q16739
SYDLDLFTMTWGPTI	GBF1	921	Q92538
LFTMTWGPTIAALSY	GBF1	926	Q92538
FMRINPLLDWTYRDI	FLAD1	511	Q8NFF5
WLLLQYLPRRYSMAT	SLC22A5	391	O76082
YWSLLAPAVEMATSS	SLC39A11	56	Q8N1S5
ALYIVRDPRAWIYSM	DSEL	1026	Q8IZU8
TMIELAILRFPYDSW	MAP2K6	246	P52564
RTWMPYIFSLSLEAL	PLEKHM1	696	Q9Y4G2
WLLEFRSSIMYLTKD	RRN3	91	Q9NYV6
LYLWIRMTFGRVFPS	SFI1	96	A8K8P3
EYWALTSPMTALPLR	TRIM27	416	P14373
MTRILYTLVDWFPVF	TMEM43	326	Q9BTV4
TLFPALIYSSTMVWL	PSEN1	281	P49768
AFMISWLPYSIDSLI	TAAR6	266	Q96RI8
MASAEPLTALSRWYL	TMEM229B	1	Q8NBD8
TMLNFFVTEYTPRSW	SAMD8	306	Q96LT4
YIWSLDATSMKFPAR	FER1L5	1801	A0AVI2
LTWILLPFMQSYARS	LMBRD2	121	Q68DH5
SLIDISSIPSYDWMR	RASGRP3	116	Q8IV61
LMEVLRPYGAFWLAS	SLC2A8	431	Q9NY64
VLSPFALPYWERLML	MED13	1346	Q9UHV7
SQRFPLPSMYRALVW	TBC1D7	46	Q9P0N9
LLVTALYMLEPWERT	SPTSSA	21	Q969W0
RTWSFFLDLASLMPT	CNGA4	111	Q8IV77
TALYLLWEMYRTEPL	CNOT11	126	Q9UKZ1
LSWLFLSYRPGMDLS	TMEM237	371	Q96Q45
VLTRFLGSSTPIMYW	PIGV	401	Q9NUD9
SSPSLSEKQYFLRWM	URGCP	556	Q8TCY9
LTSVFIWETLMAAYP	TAS2R5	251	Q9NYW4
SPLSLSAFYCLMWSL	TMEM269	211	A0A1B0GVZ9
MFPFYSCWRTGLLLL	M6PR	1	P20645
DVWLPLMSYRNSLLA	STAG2	1036	Q8N3U4
KMWRVFPYAEESLSL	WDR97	621	A6NE52
MRVYGALFWSLAPLI	SRL	266	Q86TD4
PSSLYMAWLETLSQD	SLC12A3	986	P55017
RWCTRLEMPDNLYTF	SH2B3	261	Q9UQQ2
WLLEFRSSIMYLTKD	RRN3P2	91	A6NIE6
TFVMLLPSKDFWYSV	ZDHHC7	66	Q9NXF8
DMWNLPLDSRYVTLT	TMEM169	91	Q96HH4
PFYKWMLRQETSLTS	TRIP12	1721	Q14669
WSRRYTEMALPFFSL	MYORG	486	Q6NSJ0