Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alpha-1,4-glucosidase activity	SI GAA MGAM2	4.99e-06	5	160	3	GO:0004558
GeneOntologyMolecularFunction	alpha-glucosidase activity	SI GAA MGAM2	1.73e-05	7	160	3	GO:0090599
GeneOntologyMolecularFunction	glycogen synthase activity, transferring glucose-1-phosphate	GYS1 GYS2	6.38e-05	2	160	2	GO:0061547
GeneOntologyMolecularFunction	alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity	GYS1 GYS2	1.90e-04	3	160	2	GO:0004373
GeneOntologyMolecularFunction	glucosidase activity	SI GAA MGAM2	2.14e-04	15	160	3	GO:0015926
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH17 DNAH9 DYNC1H1	3.77e-04	18	160	3	GO:0008569
GeneOntologyMolecularFunction	RNA polymerase I core binding	RRN3P2 RRN3	3.79e-04	4	160	2	GO:0001042
GeneOntologyMolecularFunction	threonine-type peptidase activity	TASP1 GGT1 GGT3P	5.21e-04	20	160	3	GO:0070003
GeneOntologyMolecularFunction	peptidyltransferase activity	GGT1 GGT3P	9.37e-04	6	160	2	GO:0000048
GeneOntologyMolecularFunction	leukotriene-C(4) hydrolase	GGT1 GGT3P	9.37e-04	6	160	2	GO:0002951
GeneOntologyCellularComponent	outer dynein arm	NME8 DNAH17 DNAH9	1.03e-04	12	166	3	GO:0036157
HumanPheno	Recurrent otitis media	STK36 POLR1A DOCK8 NEK10 TNRC6B MAGT1 ZEB2 NME8 CFAP221 ARHGAP29 TAOK1 DNAH9 GNS	6.85e-06	227	68	13	HP:0000403
Domain	Gal_mutarotase_N	SI GAA MGAM2	2.36e-06	4	158	3	IPR031727
Domain	NtCtMGAM_N	SI GAA MGAM2	2.36e-06	4	158	3	PF16863
Domain	ARM-type_fold	STK36 CLASP1 DOCK8 NEK10 UBR4 INTS1 CUL9 FMNL2 AP4E1 THADA AP2A2 XPO6 ZER1	6.42e-06	339	158	13	IPR016024
Domain	Glyco_hydro_31_AS	SI GAA MGAM2	1.17e-05	6	158	3	IPR030458
Domain	Glyco_hydro_31	SI GAA MGAM2	2.03e-05	7	158	3	IPR000322
Domain	Glyco_hydro_31	SI GAA MGAM2	2.03e-05	7	158	3	PF01055
Domain	GLYCOSYL_HYDROL_F31_1	SI GAA MGAM2	2.03e-05	7	158	3	PS00129
Domain	Trefoil	SI GAA MGAM2	3.22e-05	8	158	3	PF00088
Domain	P_TREFOIL_2	SI GAA MGAM2	4.81e-05	9	158	3	PS51448
Domain	PD	SI GAA MGAM2	4.81e-05	9	158	3	SM00018
Domain	Cytoplasmic_FMR1-int	CYFIP2 CYFIP1	7.11e-05	2	158	2	IPR008081
Domain	Glycogen_syn	GYS1 GYS2	7.11e-05	2	158	2	PF05693
Domain	Arp1	ACTR1B ACTR1A	7.11e-05	2	158	2	IPR029909
Domain	Glycogen_synth	GYS1 GYS2	7.11e-05	2	158	2	IPR008631
Domain	FragX_IP	CYFIP2 CYFIP1	7.11e-05	2	158	2	PF05994
Domain	-	SI GAA MGAM2	9.32e-05	11	158	3	4.10.110.10
Domain	P_trefoil_dom	SI GAA MGAM2	1.24e-04	12	158	3	IPR000519
Domain	Gal_mutarotase_SF_dom	SI GAA MGAM2	3.70e-04	17	158	3	IPR011013
Domain	Ion_trans_N	HCN4 HCN1	4.22e-04	4	158	2	IPR013621
Domain	RetinoicA-induced_16-like	FHIP1B FHIP1A	4.22e-04	4	158	2	IPR019384
Domain	RAI16-like	FHIP1B FHIP1A	4.22e-04	4	158	2	PF10257
Domain	Glyco_hydro_31_CS	SI GAA	4.22e-04	4	158	2	IPR030459
Domain	DUF1394	CYFIP2 CYFIP1	4.22e-04	4	158	2	IPR009828
Domain	DUF1394	CYFIP2 CYFIP1	4.22e-04	4	158	2	PF07159
Domain	Ion_trans_N	HCN4 HCN1	4.22e-04	4	158	2	PF08412
Domain	ARM-like	STK36 CLASP1 DOCK8 NEK10 CUL9 AP4E1 AP2A2 XPO6 ZER1	4.97e-04	270	158	9	IPR011989
Domain	-	STK36 CLASP1 NEK10 CUL9 AP4E1 AP2A2 XPO6 ZER1	6.15e-04	222	158	8	1.25.10.10
Domain	GLYCOSYL_HYDROL_F31_2	SI GAA	6.99e-04	5	158	2	PS00707
Domain	GCV_T	IBA57 PDPR	6.99e-04	5	158	2	PF01571
Domain	Autophagy-rel_C	ATG2B VPS13A	6.99e-04	5	158	2	IPR015412
Domain	ATG_C	ATG2B VPS13A	6.99e-04	5	158	2	PF09333
Domain	GCV_T_C	IBA57 PDPR	6.99e-04	5	158	2	IPR013977
Domain	GCV_T_C	IBA57 PDPR	6.99e-04	5	158	2	PF08669
Domain	GCV_T_N	IBA57 PDPR	6.99e-04	5	158	2	IPR006222
Domain	GGT_peptidase	GGT1 GGT3P	1.45e-03	7	158	2	IPR000101
Domain	G_glu_transpept	GGT1 GGT3P	1.45e-03	7	158	2	PF01019
Domain	G_GLU_TRANSPEPTIDASE	GGT1 GGT3P	1.45e-03	7	158	2	PS00462
Domain	VWA_3	VWA5B1 CACNA2D3	1.93e-03	8	158	2	PF13768
Domain	Chorein_N	ATG2B VPS13A	1.93e-03	8	158	2	PF12624
Domain	DHC_N1	DNAH9 DYNC1H1	1.93e-03	8	158	2	PF08385
Domain	P_TREFOIL_1	SI GAA	1.93e-03	8	158	2	PS00025
Domain	VPS13_N	ATG2B VPS13A	1.93e-03	8	158	2	IPR026854
Domain	Coatomer/calthrin_app_sub_C	AP4E1 AP2A2	1.93e-03	8	158	2	IPR009028
Domain	P_trefoil_CS	SI GAA	1.93e-03	8	158	2	IPR017957
Domain	Dynein_heavy_dom-1	DNAH9 DYNC1H1	1.93e-03	8	158	2	IPR013594
Pathway	REACTOME_DISEASES_OF_CARBOHYDRATE_METABOLISM	SI GYS1 GYS2 GNS GAA	1.02e-05	34	122	5	M27546
Pathway	REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION	POLR1A RRN3P2 GATAD2B POLR1E RRN3	5.13e-05	47	122	5	MM15428
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT	ACTR1B ACTR1A DNAH17 DNAH9	8.03e-05	27	122	4	M47755
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ITCH CLASP1 HCN4 HCN1 UBR4 TNRC6B FYCO1 TBL1XR1 ZEB2 GATAD2B CYFIP2 ACTR1A CYFIP1 AP2A2 TAX1BP1 NAV1 SMARCC2 DYNC1H1 TBL1X	2.40e-07	963	168	19	28671696
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	HIVEP2 CLASP1 UBR4 INTS1 RGS12 GATAD2B AP4E1 ACTR1B FBXL7 ANKRD12 DYNC1H1	5.37e-07	322	168	11	26514267
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CLASP1 TNRC6B CUL9 ZHX2 FHIP1B ZEB2 GRAMD1B TOMM70 GPCPD1 NAV1 ANKRD12 DYNC1H1	7.69e-07	407	168	12	12693553
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	ITCH FYCO1 MAGT1 CPT2 STAT2 ARHGAP29 HERC4 GAA	3.27e-06	183	168	8	31932471
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	TNRC6B MECOM ZEB2 GATAD2B ARHGAP29 NAV1 ANKRD12 NNT	3.41e-06	184	168	8	32908313
Pubmed	Defining the membrane proteome of NK cells.	NIBAN1 ITCH RPLP0 CLASP1 DOCK8 UBR4 INTS1 FYCO1 MAGT1 CYFIP2 GRAMD1B ACTR1B TOMM70 GYS1 TMPO PARP9 NNT DYNC1H1 GAA	4.14e-06	1168	168	19	19946888
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	UBR4 CUL9 MECOM MAGT1 CPS1 TBL1XR1 ZEB2 GATAD2B CYFIP2 XYLT1 TOMM70 SLMAP SMARCC2 DYNC1H1 GAA TBL1X	4.55e-06	857	168	16	25609649
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	SERPINA3 FAT4 NIBAN1 ITCH SI GGT1 GGT3P CYFIP2 ACTR1B ACTR1A CYFIP1 SLC12A1 PROM2 SERPING1 GNS DYNC1H1 GAA ALDH7A1	4.77e-06	1070	168	18	23533145
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	EXOSC9 CLASP1 ADRM1 ATG2B EXOC3 MAGT1 FMNL2 NME8 ACTR1B ACTR1A THADA CYFIP1 AP2A2 XPO6 GYS1 NAV1 PPIH DYNC1H1 PCK2 CCDC93	6.60e-06	1321	168	20	27173435
Pubmed	Interaction network of human early embryonic transcription factors.	HIVEP2 MECOM RAD54L2 ZHX2 TBL1XR1 ZEB2 TOMM70 SMARCC2 TAF12 TBL1X	8.85e-06	351	168	10	38297188
Pubmed	Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.	RRN3P2 RRN3	2.32e-05	2	168	2	12015311
Pubmed	Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia.	CYFIP2 CYFIP1	2.32e-05	2	168	2	38128786
Pubmed	TBL1X: At the crossroads of transcriptional and posttranscriptional regulation.	TBL1XR1 TBL1X	2.32e-05	2	168	2	36206873
Pubmed	Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.	HCN4 HCN1	2.32e-05	2	168	2	17548059
Pubmed	A neuroprotective phase precedes striatal degeneration upon nucleolar stress.	RRN3P2 RRN3	2.32e-05	2	168	2	23764776
Pubmed	Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins.	ACTR1B ACTR1A	2.32e-05	2	168	2	7696711
Pubmed	Non-motor symptoms associated with progressive loss of dopaminergic neurons in a mouse model of Parkinson's disease.	RRN3P2 RRN3	2.32e-05	2	168	2	38745938
Pubmed	Function of the growth-regulated transcription initiation factor TIF-IA in initiation complex formation at the murine ribosomal gene promoter.	RRN3P2 RRN3	2.32e-05	2	168	2	8413268
Pubmed	Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism.	RRN3P2 RRN3	2.32e-05	2	168	2	30918302
Pubmed	Cytoplasmic FMRP interacting protein 1/2 (CYFIP1/2) expression analysis in autism.	CYFIP2 CYFIP1	2.32e-05	2	168	2	29752658
Pubmed	Restoration of muscle functionality by genetic suppression of glycogen synthesis in a murine model of Pompe disease.	GYS1 GAA	2.32e-05	2	168	2	19959526
Pubmed	Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning.	RRN3P2 RRN3	2.32e-05	2	168	2	27257073
Pubmed	ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.	RRN3P2 RRN3	2.32e-05	2	168	2	12620228
Pubmed	Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling.	UBR4 STAT2	2.32e-05	2	168	2	23555265
Pubmed	C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.	CYFIP2 CYFIP1	2.32e-05	2	168	2	24357318
Pubmed	Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells.	HCN4 HCN1	2.32e-05	2	168	2	21456027
Pubmed	Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli.	HCN4 HCN1	2.32e-05	2	168	2	11675786
Pubmed	Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases.	RRN3P2 RRN3	2.32e-05	2	168	2	31110473
Pubmed	SUMOylation of TBL1 and TBLR1 promotes androgen-independent prostate cancer cell growth.	TBL1XR1 TBL1X	2.32e-05	2	168	2	27129164
Pubmed	DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.	RRN3P2 RRN3	2.32e-05	2	168	2	23393135
Pubmed	Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons.	RRN3P2 RRN3	2.32e-05	2	168	2	24273493
Pubmed	Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders.	CYFIP2 CYFIP1	2.32e-05	2	168	2	34327661
Pubmed	Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.	HCN4 HCN1	2.32e-05	2	168	2	19135060
Pubmed	Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion.	CYFIP2 CYFIP1	2.32e-05	2	168	2	35567753
Pubmed	Cyfip1 Haploinsufficiency Increases Compulsive-Like Behavior and Modulates Palatable Food Intake in Mice: Dependence on Cyfip2 Genetic Background, Parent-of Origin, and Sex.	CYFIP2 CYFIP1	2.32e-05	2	168	2	31324746
Pubmed	Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain.	FAT4 NAV1 GAA	2.36e-05	12	168	3	23342162
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	STK36 HIVEP2 UBR4 INTS1 TASP1 CUL9 FYCO1 FHIP1B TEP1 ACTR1A THADA PROM2 KLHL36 XPO6 NAV1 ZER1 DYNC1H1	2.77e-05	1105	168	17	35748872
Pubmed	The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.	FHIP1B AP4E1 FHIP1A	3.06e-05	13	168	3	32073997
Pubmed	FACT facilitates chromatin transcription by RNA polymerases I and III.	POLR1A POLR1E RRN3	3.06e-05	13	168	3	19214185
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	MECOM TSNAX TBL1XR1 GATAD2B SMARCC2 DYNC1H1	3.87e-05	128	168	6	23858473
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	POLR1A RPLP0 UBR4 EXOC3 MECOM MAGT1 FMNL2 TMPO SMARCC2 TAOK1 DYNC1H1 PCK2	3.90e-05	601	168	12	33658012
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	SGTB ATG2B MAGT1 FBXL7 AP2A2 POLR1E CXXC4 NAV1 PCK2 GAA	4.02e-05	419	168	10	33001583
Pubmed	Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.	HCN4 HCN1	6.94e-05	3	168	2	22652004
Pubmed	Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.	HCN4 HCN1	6.94e-05	3	168	2	21187420
Pubmed	Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.	HCN4 HCN1	6.94e-05	3	168	2	21945247
Pubmed	Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.	HCN4 HCN1	6.94e-05	3	168	2	22006928
Pubmed	Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression.	ITCH SLC6A4	6.94e-05	3	168	2	15589347
Pubmed	Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines.	SGTB TMPO	6.94e-05	3	168	2	2158125
Pubmed	Relationship between glycogen accumulation and the laforin dual specificity phosphatase.	GYS1 GAA	6.94e-05	3	168	2	17022935
Pubmed	TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS.	ITCH TAX1BP1	6.94e-05	3	168	2	27736772
Pubmed	HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.	HCN4 HCN1	6.94e-05	3	168	2	33181864
Pubmed	TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation.	RRN3P2 RRN3	6.94e-05	3	168	2	19217408
Pubmed	Bavachin exerted anti-neuroinflammatory effects by regulation of A20 ubiquitin-editing complex.	ITCH TAX1BP1	6.94e-05	3	168	2	34454289
Pubmed	EP3 activation facilitates bladder excitability via HCN channels on ICCs.	HCN4 HCN1	6.94e-05	3	168	2	28131828
Pubmed	Nucleolar stress controls mutant Huntington toxicity and monitors Huntington's disease progression.	RRN3P2 RRN3	6.94e-05	3	168	2	34880223
Pubmed	Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney.	GGT1 GGT3P	6.94e-05	3	168	2	2573352
Pubmed	Syndrome disintegration: Exome sequencing reveals that Fitzsimmons syndrome is a co-occurrence of multiple events.	TBL1XR1 SACS	6.94e-05	3	168	2	27133561
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	EXOSC9 CPS1 TBL1XR1 GATAD2B TMPO DYNC1H1 PCK2 TBL1X	1.08e-04	298	168	8	30737378
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	SERPINA3 PRAMEF33 MMS22L EXOSC9 PRAMEF10 CPT2 CYFIP2 AP4E1 CYFIP1 FBXL7 AP2A2 POLR1E GYS2 DNAH17 VPS13A FHIP1A VWA5B1	1.16e-04	1242	168	17	30973865
Pubmed	Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.	OPN4 HCN4 HCN1	1.38e-04	21	168	3	30270038
Pubmed	Functional expression of the human HCN3 channel.	HCN4 HCN1	1.38e-04	4	168	2	16043489
Pubmed	Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.	HCN4 HCN1	1.38e-04	4	168	2	9405696
Pubmed	Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.	HCN4 HCN1	1.38e-04	4	168	2	12928435
Pubmed	Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.	HCN4 HCN1	1.38e-04	4	168	2	20140458
Pubmed	Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.	HCN4 HCN1	1.38e-04	4	168	2	22748890
Pubmed	Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth.	CYFIP2 CYFIP1	1.38e-04	4	168	2	27605705
Pubmed	Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.	HCN4 HCN1	1.38e-04	4	168	2	9630217
Pubmed	Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.	CYFIP2 CYFIP1	1.38e-04	4	168	2	20228810
Pubmed	ZER1 Contributes to the Carcinogenic Activity of High-Risk HPV E7 Proteins.	UBR4 ZER1	1.38e-04	4	168	2	36346242
Pubmed	TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis.	TBL1XR1 TBL1X	1.38e-04	4	168	2	18193033
Pubmed	Vitamin C enhances Nanog expression via activation of the JAK/STAT signaling pathway.	STAT2 NANOGP1	1.38e-04	4	168	2	23963652
Pubmed	TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints.	TBL1XR1 TBL1X	1.38e-04	4	168	2	18374649
Pubmed	Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus.	SLC6A4 TAOK1	1.38e-04	4	168	2	37656623
Pubmed	Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.	HCN4 HCN1	1.38e-04	4	168	2	21615589
Pubmed	Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development.	CYFIP2 CYFIP1	1.38e-04	4	168	2	15294869
Pubmed	Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA.	RRN3P2 RRN3	1.38e-04	4	168	2	24297901
Pubmed	Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models.	RRN3P2 RRN3	1.38e-04	4	168	2	28360124
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	NIBAN1 POLR1A RPLP0 INTS1 MECOM CPT2 AP2A2 SACS ALDH7A1	1.53e-04	400	168	9	35013556
Pubmed	Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.	POLR1A POLR1E RRN3	1.83e-04	23	168	3	12393749
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	RPLP0 CLASP1 DOCK8 FMNL2 CYFIP2 GRAMD1B ACTR1A TOMM70 CYFIP1 CLCN6 AP2A2 SACS NAV1 TMPO SMARCC2 DYNC1H1 ALDH7A1 CACNA2D3	2.07e-04	1431	168	18	37142655
Pubmed	Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary γ-glutamyltransferase deficiency.	GGT1 GGT3P	2.30e-04	5	168	2	23615310
Pubmed	Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes.	STAT2 SMARCC2	2.30e-04	5	168	2	12244326
Pubmed	Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.	HCN4 HCN1	2.30e-04	5	168	2	15564593
Pubmed	Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I.	RRN3P2 RRN3	2.30e-04	5	168	2	18559419
Pubmed	gamma-glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial function, and cellular function.	GGT1 GGT3P	2.30e-04	5	168	2	11003618
Pubmed	A screen for MeCP2-TBL1 interaction inhibitors using a luminescence-based assay.	TBL1XR1 TBL1X	2.30e-04	5	168	2	36890145
Pubmed	Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase.	GGT1 GGT3P	2.30e-04	5	168	2	2904146
Pubmed	The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis.	RRN3P2 RRN3	2.30e-04	5	168	2	15805466
Pubmed	Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species.	GGT1 GGT3P	2.30e-04	5	168	2	10392451
Pubmed	Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress.	GGT1 GGT3P	2.30e-04	5	168	2	19850887
Pubmed	Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice.	GGT1 GGT3P	2.30e-04	5	168	2	12810527
Pubmed	Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice.	GGT1 GGT3P	2.30e-04	5	168	2	8755578
Pubmed	Reproductive defects in gamma-glutamyl transpeptidase-deficient mice.	GGT1 GGT3P	2.30e-04	5	168	2	11089562
Pubmed	N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice.	GGT1 GGT3P	2.30e-04	5	168	2	26977590
Pubmed	Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxia.	GGT1 GGT3P	2.30e-04	5	168	2	12225953
Pubmed	Identification of a sixth promoter that directs the transcription of gamma-glutamyl transpeptidase type III RNA in mouse.	GGT1 GGT3P	2.30e-04	5	168	2	7775425
Pubmed	Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.	HCN4 HCN1	2.30e-04	5	168	2	34429357
Pubmed	Mice with genetic gamma-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility.	GGT1 GGT3P	2.30e-04	5	168	2	9139708
Pubmed	Analysis of site-specific glycosylation of renal and hepatic γ-glutamyl transpeptidase from normal human tissue.	GGT1 GGT3P	2.30e-04	5	168	2	20622017
Pubmed	Accelerated methylmercury elimination in gamma-glutamyl transpeptidase-deficient mice.	GGT1 GGT3P	2.30e-04	5	168	2	9546365
Interaction	TNIK interactions	CLASP1 HCN1 TBL1XR1 ZEB2 GATAD2B CYFIP2 SLC6A4 ACTR1A CYFIP1 AP2A2 SLMAP SMARCC2 DYNC1H1	8.75e-06	381	156	13	int:TNIK
Interaction	PSG8 interactions	FAT4 PDPR ADGRV1 GFM2 ANKRD46	1.56e-05	41	156	5	int:PSG8
Interaction	DYNC1I2 interactions	CLASP1 ADRM1 MECOM TSNAX RGS12 ACTR1B ACTR1A FHIP1A GNS DYNC1H1 ALDH7A1	1.95e-05	295	156	11	int:DYNC1I2
GeneFamily	Olfactory receptors, family 11	OR11H12 OR11H1 OR11H2	3.10e-04	23	105	3	159
GeneFamily	Cyclic nucleotide gated channels	HCN4 HCN1	1.46e-03	10	105	2	250
GeneFamily	Glycosyl transferases group 1 domain containing	GYS1 GYS2	1.46e-03	10	105	2	427
ToppCell	TCGA-Colorectal-Recurrent_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	HJV SERPINA3 PRAMEF33 PRAMEF10 INHBC OR10J6P UROC1 GYS2	3.49e-07	175	168	8	7f74961436f88c0e380819095e6104489914d765
ToppCell	TCGA-Colorectal-Recurrent_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	HJV SERPINA3 PRAMEF33 PRAMEF10 INHBC OR10J6P UROC1 GYS2	3.49e-07	175	168	8	bee8f31f036dfcf9fc6ed29156554771a9ee3c60
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEK10 MECOM ADGRV1 CYFIP2 SLC12A1 PROM2 NNT CACNA2D3	5.78e-07	187	168	8	85e58a312fc325e4063a2d250666b99b8f99beb6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEK10 MECOM ADGRV1 CYFIP2 SLC12A1 PROM2 NNT CACNA2D3	5.78e-07	187	168	8	52b5b38bef3cc06487cf42c6fb22fb33f0c7ce2b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEK10 MECOM ADGRV1 CA10 SLC12A1 CFAP221 ARHGAP29 CACNA2D3	6.52e-07	190	168	8	bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEK10 MECOM ADGRV1 CA10 SLC12A1 CFAP221 ARHGAP29 CACNA2D3	6.52e-07	190	168	8	b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEK10 MECOM ADGRV1 CA10 SLC12A1 CFAP221 ARHGAP29 CACNA2D3	6.78e-07	191	168	8	2fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM ADGRV1 CA10 CYFIP2 SLC12A1 CFAP221 CACNA2D3	2.58e-06	160	168	7	03b88dc7ad41c6ae443cab7e77ec666340bf432e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM ADGRV1 CA10 CYFIP2 SLC12A1 CFAP221 CACNA2D3	4.66e-06	175	168	7	e5467dacf81f1f913b1719931cf1a7331434a7e7
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM ADGRV1 CA10 CYFIP2 SLC12A1 PROM2 CACNA2D3	5.61e-06	180	168	7	eee71184ebed2694d3e60f579a44b3cf7dd2cd35
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM ADGRV1 CA10 CYFIP2 SLC12A1 PROM2 CACNA2D3	5.61e-06	180	168	7	a17dbe03597b81e7a1fe2bf2d23e59e55c615a2a
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 FAT4 STAB2 ADGRV1 CPS1 LOXHD1 DNAH9	6.47e-06	184	168	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 FAT4 STAB2 ADGRV1 CPS1 LOXHD1 DNAH9	6.47e-06	184	168	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 FAT4 STAB2 ADGRV1 CPS1 LOXHD1 DNAH9	6.47e-06	184	168	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COVID-19-kidney-Mito-rich_Distal\|kidney / Disease (COVID-19 only), tissue and cell type	NEK10 MECOM ADGRV1 CA10 SLC12A1 CFAP221 CACNA2D3	7.20e-06	187	168	7	2ce8038d9d1302e850c1bb536e755598f77ba4b9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM ADGRV1 CA10 CYFIP2 SLC12A1 CFAP221 CACNA2D3	7.20e-06	187	168	7	7ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM ADGRV1 CA10 CYFIP2 SLC12A1 CFAP221 CACNA2D3	7.45e-06	188	168	7	2ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM ADGRV1 CA10 CYFIP2 SLC12A1 CFAP221 CACNA2D3	7.45e-06	188	168	7	3cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM ADGRV1 CA10 CYFIP2 SLC12A1 CFAP221 CACNA2D3	7.71e-06	189	168	7	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RPLP0 MECOM CA10 CYFIP2 SLC12A1 SERPING1 CACNA2D3	7.71e-06	189	168	7	55420853f730b433ef58ac9337ac84ac78a247a0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM CA10 CYFIP2 SLC12A1 CFAP221 FHIP1A CACNA2D3	7.98e-06	190	168	7	cc17ab84a9328124f146951c06be3eff9650d9fd
ToppCell	COVID-19-kidney-TAL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NEXMIF MECOM CA10 SLC12A1 CFAP221 FHIP1A CACNA2D3	8.26e-06	191	168	7	fe55475ce0666ab5122447a813dc2369e24947b8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM ADGRV1 CA10 CYFIP2 SLC12A1 CFAP221 CACNA2D3	8.55e-06	192	168	7	562df5e87038c500dd3a003fe5374cb31946b145
ToppCell	COVID-19-kidney-TAL\|kidney / Disease (COVID-19 only), tissue and cell type	NEXMIF MECOM ADGRV1 CA10 SLC12A1 FHIP1A CACNA2D3	9.78e-06	196	168	7	04f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	CLASP1 TNRC6B MECOM ZHX2 TBL1XR1 FMNL2 HERC4	1.08e-05	199	168	7	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NIBAN1 DOCK8 AOAH CA10 XYLT1 GRAMD1B SLFN12L	1.08e-05	199	168	7	fbdde57dd88656621801e65ee2818251588f3874
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DOCK8 ZEB2 STAT2 SERPING1 PARP9 ANKRD12 DYNC1H1	1.11e-05	200	168	7	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NIBAN1 DOCK8 AOAH CA10 XYLT1 GRAMD1B SLFN12L	1.11e-05	200	168	7	8474e5d031d25bfb8461d39fa2053da01a6304fc
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HCN1 ADGRV1 CPS1 SLC12A1 DNAH9 CACNA2D3	3.27e-05	160	168	6	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HCN1 ADGRV1 CPS1 SLC12A1 DNAH9 CACNA2D3	3.27e-05	160	168	6	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POLR1A TEP1 ADORA3 THADA POLR1E PARP9	3.50e-05	162	168	6	388670cf3acef17df971c0d8ae3ce14398945192
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POLR1A TEP1 ADORA3 THADA POLR1E PARP9	3.50e-05	162	168	6	9333d923225df7bfdf6b3a4c32816751315aec50
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEK10 NME8 LRRC9 PROM2 CFAP221 VWA5B1	4.58e-05	170	168	6	b535baeb4dbd644051cf992babb61add9eaae4e3
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEK10 NME8 LRRC9 PROM2 CFAP221 VWA5B1	4.58e-05	170	168	6	2477c9f29dbe27f172df699003971e828d6ab8c9
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK8 TSNAX CPS1 CPT2 ANKRD46 SERPING1	4.58e-05	170	168	6	07b561cd9c528bc8444c9385e1de621eee7b697e
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8\|TCGA-Liver / Sample_Type by Project: Shred V9	PRAMEF33 PRAMEF10 UROC1 CES2 GYS2 SERPING1	4.74e-05	171	168	6	c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	UBR4 FMNL2 CYFIP2 GPCPD1 SERPING1 GNS	5.22e-05	174	168	6	d77fa525d5c87c190b4a10787b270eabd16c610f
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK8 NUP210L FMNL2 ZEB2 GPCPD1 GAA	5.22e-05	174	168	6	d5c22b43531414951666ee7542a66ed9380e2d14
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM ADGRV1 CYFIP2 SLC12A1 CFAP221 CACNA2D3	5.92e-05	178	168	6	4df6218b20c2f076c22346d23260964cc0d73e65
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRMPD2 LOXHD1 CFAP221 CXXC4 ARHGAP29 TBL1X	5.92e-05	178	168	6	f7f88879a05b2b5fa92cf5317b76f7a3064d1358
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEK10 MECOM ADGRV1 CYFIP2 SLC12A1 CACNA2D3	6.30e-05	180	168	6	9e09b3dfe344b5d50520711513d389865d73a861
ToppCell	facs-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 HIVEP2 STAT2 XYLT1 NAV1 SERPING1	6.30e-05	180	168	6	12537d8a569faa69f474284d2c201475722b8ca1
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM CA10 SLC12A1 SLMAP FHIP1A CACNA2D3	6.69e-05	182	168	6	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM ADGRV1 CA10 CYFIP2 SLC12A1 CACNA2D3	6.69e-05	182	168	6	041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM ADGRV1 CA10 CYFIP2 SLC12A1 CACNA2D3	6.90e-05	183	168	6	31ab55d5f3639f5964541d5eae23044dbda3356e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM ADGRV1 CPS1 CA10 SLC12A1 CACNA2D3	7.11e-05	184	168	6	8fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MECOM ADGRV1 CYFIP2 UNC5CL FHIP1A CACNA2D3	7.33e-05	185	168	6	0d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 NEK10 ZFPM2 UNC5CL DNAH9 FHIP1A	7.33e-05	185	168	6	05bc89a566b0db90ae06506e067190a4739a0974
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEK10 MECOM CA10 CYFIP2 SLC12A1 CACNA2D3	7.33e-05	185	168	6	03f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM ADGRV1 CA10 CYFIP2 SLC12A1 CACNA2D3	7.33e-05	185	168	6	898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HCN1 ADGRV1 ZEB2 C18orf63 NAV1 TBL1X	7.55e-05	186	168	6	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEK10 MECOM CA10 CYFIP2 SLC12A1 CACNA2D3	7.55e-05	186	168	6	1850583d23903d08226aeb0edb3e07b0994330e4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEK10 MECOM CA10 CYFIP2 SLC12A1 CACNA2D3	7.55e-05	186	168	6	4dafc215c42e7949f932a3627359c107943b5d6b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM CA10 SLC12A1 SLMAP FHIP1A CACNA2D3	7.77e-05	187	168	6	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM CA10 SLC12A1 SLMAP FHIP1A CACNA2D3	7.77e-05	187	168	6	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM CA10 SLC12A1 SLMAP FHIP1A CACNA2D3	7.77e-05	187	168	6	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRV1 RGS12 CFAP221 DNAH17 ARHGAP29 CACNA2D3	7.77e-05	187	168	6	c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	TNRC6B ZEB2 GPCPD1 TAOK1 ANKRD12 DYNC1H1	8.00e-05	188	168	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEXMIF MECOM ADGRV1 CA10 SLC12A1 CACNA2D3	8.24e-05	189	168	6	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRV1 RGS12 CFAP221 DNAH17 ARHGAP29 CACNA2D3	8.48e-05	190	168	6	1cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM CA10 CYFIP2 SLC12A1 CFAP221 CACNA2D3	8.48e-05	190	168	6	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRV1 RGS12 CFAP221 DNAH17 ARHGAP29 CACNA2D3	8.48e-05	190	168	6	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM CA10 CYFIP2 SLC12A1 CFAP221 CACNA2D3	8.48e-05	190	168	6	3dcadabbefe0128a5f30ab51234f049ab4d870c6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM ADGRV1 CA10 SLC12A1 FHIP1A CACNA2D3	8.73e-05	191	168	6	963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCell	COVID-19-kidney-Mito-rich_Distal\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NEXMIF MECOM CA10 SLC12A1 CFAP221 CACNA2D3	8.73e-05	191	168	6	0965f621ebcd92ccdeb21cc27022180ce3cfe910
ToppCell	COVID-19-lung-CD4+_Treg\|lung / Disease (COVID-19 only), tissue and cell type	NIBAN1 DOCK8 CYFIP2 XYLT1 GRAMD1B SLFN12L	8.73e-05	191	168	6	73ea3078c1f55cd47e4d99e77b3ce4ff17549d49
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NEK10 FRMPD2 ADGRV1 STOX1 CFAP221 DNAH9	9.25e-05	193	168	6	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM CYFIP2 SLC12A1 CFAP221 FHIP1A CACNA2D3	9.51e-05	194	168	6	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	control-Myeloid-Neutrophils_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CASP4 STAT2 R3HDM4 XPO6 SERPING1 PARP9	9.51e-05	194	168	6	267e213e8efe53aadfe553a2ca010a0e3b4b8939
ToppCell	COVID-19-lung-CD4+_T_cells_metabolically_active\|lung / Disease (COVID-19 only), tissue and cell type	NIBAN1 DOCK8 CYFIP2 XYLT1 GRAMD1B SLFN12L	9.51e-05	194	168	6	2a144a1c2d537c8a59aa419206ddd96c23f0aeab
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM CYFIP2 SLC12A1 CFAP221 FHIP1A CACNA2D3	9.79e-05	195	168	6	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NIBAN1 NEK10 MECOM ADGRV1 PROM2 FHIP1A	9.79e-05	195	168	6	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	CLASP1 MECOM ADGRV1 ZHX2 HERC4 FHIP1A	1.01e-04	196	168	6	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM CYFIP2 SLC12A1 CFAP221 FHIP1A CACNA2D3	1.01e-04	196	168	6	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	COVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi\|lung / Disease (COVID-19 only), tissue and cell type	DOCK8 AOAH FMNL2 ZEB2 GRAMD1B GPCPD1	1.03e-04	197	168	6	3896729740d151f0eb845f1961c7b969bfbdd28d
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	USP16 ZEB2 STAT2 SERPING1 PARP9 ANKRD12	1.03e-04	197	168	6	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	control-Myeloid-Neutrophils_2\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	NIBAN1 CASP4 R3HDM4 XPO6 SERPING1 PARP9	1.03e-04	197	168	6	8819db1550bf14566c6d33d97f7f83419e867ace
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NIBAN1 DOCK8 AOAH ZEB2 XYLT1 SLFN12L	1.03e-04	197	168	6	61ef3f417767c3f5296a26399da63e3e4f58faf8
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Tac1-Inhibitory_Neuron.Gad1Gad2_Pvalb.Tac1_(Interneuron,_Basket_1)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	OPN4 PDE6C LOXHD1 MYBPC1	1.06e-04	65	168	4	25d2f56f6cd982a227772f8a3b453cdcc8516a47
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Tac1-Inhibitory_Neuron.Gad1Gad2_Pvalb.Tac1_(Interneuron,_Basket_1)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	OPN4 PDE6C LOXHD1 MYBPC1	1.06e-04	65	168	4	d7d571be0662967e6d8d934e45f928a2f9e1c06a
ToppCell	COVID-19_Mild\|World / Disease condition and Cell class	ZEB2 STAT2 GPCPD1 SERPING1 PARP9 DYNC1H1	1.06e-04	198	168	6	61ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	USP16 ZEB2 STAT2 SERPING1 PARP9 ANKRD12	1.06e-04	198	168	6	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USP16 ZEB2 STAT2 SERPING1 PARP9 ANKRD12	1.06e-04	198	168	6	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FMNL2 ZEB2 ADORA3 CYFIP1 SERPING1 GAA	1.09e-04	199	168	6	b827dd8a249f904a0ff930a6c4d3b00fb7bc6fb1
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NIBAN1 DOCK8 AOAH XYLT1 GRAMD1B SLFN12L	1.09e-04	199	168	6	0d6463e368fd611a17327322413fad145f3c7f32
ToppCell	control-HLA-DR+_CD83+_Monocyte\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NIBAN1 AOAH ZEB2 STAT2 CYFIP1 SERPING1	1.09e-04	199	168	6	f1b370d2869ad29c9d8ff41fdcc486fffa781ee2
ToppCell	(08)_Brush+PNEC\|World / shred by cell type by condition	CALHM3 FMNL2 GYS2 CXXC4 NAV1 MYBPC1	1.09e-04	199	168	6	f2e33cb569c25fc2732722cac295647e9bd8738f
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FMNL2 ZEB2 ADORA3 CYFIP1 SERPING1 GAA	1.09e-04	199	168	6	c0dcdda30485bb920d3706dcfb06f11b76b6ea37
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK8 FMNL2 ZEB2 GPCPD1 SERPING1 GAA	1.09e-04	199	168	6	8e9862907b15809d083216e7d6a0f435015e5d15
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NIBAN1 DOCK8 AOAH CYFIP2 XYLT1 SLFN12L	1.12e-04	200	168	6	c6c2b39359c65c9444987d02d1c899dff2ad1366
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NIBAN1 DOCK8 CYFIP2 XYLT1 GRAMD1B SLFN12L	1.12e-04	200	168	6	9de4d6ebb7e9bee5d811519eb05913ef30f70786
ToppCell	control-Neutrophil\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	UBR4 AOAH CYFIP1 GPCPD1 GNS GAA	1.12e-04	200	168	6	b5d197472799cc61d7497faed91ac2564ae4930a
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_TRM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NIBAN1 DOCK8 AOAH CA10 XYLT1 SLFN12L	1.12e-04	200	168	6	9ef322486e46e4ff05a8cbe06cf8019e996c94b3
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_smooth_muscle-like\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FMNL2 CYFIP2 LRRC9 XYLT1 CXXC4	1.44e-04	132	168	5	9633653dba1edee47d915212fb6e68426da49de5
Disease	Down syndrome (biomarker_via_orthology)	RPLP0 RPLP0P6	2.74e-05	2	155	2	DOID:14250 (biomarker_via_orthology)
Disease	Seasonal Affective Disorder	OPN4 SLC6A4 NPAS2	7.57e-05	16	155	3	C0085159
Disease	chromosome 15q11.2 deletion syndrome (implicated_via_orthology)	CYFIP2 CYFIP1	8.20e-05	3	155	2	DOID:0060393 (implicated_via_orthology)
Disease	sick sinus syndrome (implicated_via_orthology)	HCN4 HCN1	8.20e-05	3	155	2	DOID:13884 (implicated_via_orthology)
Disease	sensory system disease (implicated_via_orthology)	TBL1XR1 TBL1X	8.20e-05	3	155	2	DOID:0050155 (implicated_via_orthology)
Disease	interleukin 7 measurement	HCN1 ANKRD46 XYLT1 NPAS2	9.23e-05	45	155	4	EFO_0008189
Disease	potassium measurement	CLASP1 NEK10 RGS12 AP4E1	9.23e-05	45	155	4	EFO_0009283
Disease	mean platelet volume	NIBAN1 HIVEP2 DOCK8 NUP210L MECOM CPS1 RGS12 ZFPM2 ANKRD46 GRAMD1B SLC6A4 GYS2 SERPING1 TAOK1 NNT PCDHGA8	9.87e-05	1020	155	16	EFO_0004584
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	NEK10 TNRC6B ZFPM2	1.09e-04	18	155	3	EFO_1000649, HP_0000131
Disease	sensorineural hearing loss (implicated_via_orthology)	OPN4 DNAH17 DNAH9	1.30e-04	19	155	3	DOID:10003 (implicated_via_orthology)
Disease	Neurodevelopmental Disorders	DOCK8 NEXMIF TNRC6B TBL1XR1 CACNA2D3	1.34e-04	93	155	5	C1535926
Disease	Lafora disease (implicated_via_orthology)	GYS1 GYS2	1.63e-04	4	155	2	DOID:3534 (implicated_via_orthology)
Disease	Arthrogryposis	MAGEL2 GFM2 DYNC1H1	1.76e-04	21	155	3	C0003886
Disease	Glycogen Storage Disease	GYS1 GYS2 GAA	3.79e-04	27	155	3	C0017919
Disease	uric acid measurement	FAT4 POLR1A INHBC MECOM ADGRV1 CPS1 UNC5CL NAV1 HERC4 CACNA2D3 NPAS2	3.99e-04	610	155	11	EFO_0004761
Disease	urinary potassium to creatinine ratio	NEK10 CPS1	4.06e-04	6	155	2	EFO_0009882
Disease	gamma-glutamylglycine measurement	CPS1 GGT1	5.66e-04	7	155	2	EFO_0800670
Disease	hepatocyte growth factor activator measurement	RGS12 SLC6A4	5.66e-04	7	155	2	EFO_0008152
Disease	aflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)	GGT1 GGT3P	5.66e-04	7	155	2	DOID:5022 (biomarker_via_orthology)
Disease	retinal degeneration (implicated_via_orthology)	OPN4 PDE6C PROM2	6.91e-04	33	155	3	DOID:8466 (implicated_via_orthology)
Disease	alcohol dependence (biomarker_via_orthology)	GGT1 GGT3P	7.52e-04	8	155	2	DOID:0050741 (biomarker_via_orthology)
Disease	Kartagener Syndrome	STK36 CFAP221 DNAH9	8.22e-04	35	155	3	C0022521
Disease	Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus	STK36 CFAP221 DNAH9	8.22e-04	35	155	3	C4551906
Disease	Polynesian Bronchiectasis	STK36 CFAP221 DNAH9	8.22e-04	35	155	3	C4317124
Disease	Epstein Barr viral capsid antigen seropositivity	THADA CACNG5	9.63e-04	9	155	2	EFO_0009272
Disease	Generalized Epilepsy with Febrile Seizures Plus	HCN1 ADGRV1	9.63e-04	9	155	2	C3502809
Disease	pancreatic hormone measurement	FRMPD2 MECOM	1.20e-03	10	155	2	EFO_0020621
Disease	3-methylglutarylcarnitine (2) measurement	CPS1 CPT2	1.46e-03	11	155	2	EFO_0800074
Disease	lifestyle measurement	MMS22L HIVEP2 CA10 RGS12 FHIP1A CACNA2D3	1.56e-03	235	155	6	EFO_0010724
Disease	aspartate aminotransferase to alanine aminotransferase ratio	MECOM USP16 RGS12 CYFIP2 CLCN6 ARHGAP29	1.70e-03	239	155	6	EFO_0010934
Disease	S-warfarin measurement	MAGEL2 HCN1 ZHX2 CLCA2	1.74e-03	97	155	4	EFO_0803323
Disease	Myeloproliferative disease	ATG2B MECOM	1.75e-03	12	155	2	C0027022
Disease	response to angiotensin-converting enzyme inhibitor, Cough	NIBAN1 CLASP1 GYS2	1.83e-03	46	155	3	EFO_0005325, HP_0012735
Disease	lymphocyte count	MMS22L ADRM1 RRN3P2 TNRC6B UROC1 CPS1 FMNL2 ZFPM2 ANKRD46 GRAMD1B SLC6A4 SLFN12L THADA SLC12A1 XPO6 DNAH17 PCDHGA8	1.84e-03	1464	155	17	EFO_0004587
Disease	Primary Ciliary Dyskinesia	STK36 CFAP221 DNAH9	1.95e-03	47	155	3	C4551720
Disease	Intellectual Disability	HIVEP2 DOCK8 UROC1 AP4E1 SACS SMARCC2 TAOK1 DYNC1H1	2.59e-03	447	155	8	C3714756
Disease	response to olanzapine	ADGRV1 ZFPM2	2.75e-03	15	155	2	GO_0097333
Disease	hair morphology measurement	AOAH FBXL7 CACNA2D3	2.90e-03	54	155	3	EFO_0007821
Disease	diastolic blood pressure, systolic blood pressure	HCN4 NEK10 HCN1 TNRC6B MECOM RGS12 XYLT1 CLCA2 NAV1 NPAS2	2.95e-03	670	155	10	EFO_0006335, EFO_0006336
Disease	Tremor, Rubral	HCN1 UROC1	3.13e-03	16	155	2	C0750940
Disease	Ataxia, Appendicular	HCN1 UROC1	3.13e-03	16	155	2	C0750937
Disease	Ataxia, Motor	HCN1 UROC1	3.13e-03	16	155	2	C0278161
Disease	Ataxia, Sensory	HCN1 UROC1	3.13e-03	16	155	2	C0240991
Disease	Abnormal coordination	HCN1 UROC1	3.13e-03	16	155	2	C0520966
Disease	Ataxia, Truncal	HCN1 UROC1	3.13e-03	16	155	2	C0427190
Disease	factor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement	ITCH CPS1 GYS2	3.21e-03	56	155	3	EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Disease	glutarylcarnitine (C5-DC) measurement	CPS1 CPT2	3.54e-03	17	155	2	EFO_0800030
Disease	Myeloid Leukemia	ATG2B MECOM	3.97e-03	18	155	2	C0023470
Disease	Leukemia, Monocytic, Chronic	ATG2B MECOM	3.97e-03	18	155	2	C0023466
Disease	triglyceride measurement, body mass index	STK36 INHBC	4.42e-03	19	155	2	EFO_0004340, EFO_0004530
Disease	temporal lobe epilepsy (is_marker_for)	HCN1 CYFIP1	4.90e-03	20	155	2	DOID:3328 (is_marker_for)
Disease	citrulline measurement	MECOM CPS1	4.90e-03	20	155	2	EFO_0009777
Disease	obsolete_red blood cell distribution width	POLR1A CLASP1 DOCK8 AOAH MECOM CPS1 TBL1XR1 ZFPM2 SLFN12L CYFIP1 LOXHD1 CLCN6 VPS13A TAOK1 ANKRD12	5.00e-03	1347	155	15	EFO_0005192

Protein segments in the cluster

Peptide	Gene	Start	Entry
QNYSMPTSSFRNLLE	PRAMEF33	186	A0A0G2JMD5
ATGLIPFQMVSFQAS	BAAT	21	Q14032
MPNNSTALSLANVTY	ADORA3	1	P0DMS8
TDTQNIFFMSKVTNP	SERPINA3	406	P01011
AAFMSTLLINQPQYA	ALDH7A1	26	P49419
MLLQTFFNIDQISPN	CASP4	71	P49662
KFLDFANMTPSQVQL	CALHM3	136	Q86XJ0
FIMPAKTNNFNVETL	GYS2	366	P54840
EQTFMFPENQPVSSL	FAT4	2571	Q6V0I7
TFNVPALFISMQAVL	ACTR1B	131	P42025
DNAFGIISFNMLPSI	ADGRV1	141	Q8WXG9
LPLESNLAFMNGVSF	IBA57	241	Q5T440
MSTIQNLQSFDPFAD	EIF1B	1	O60739
TTPFTSQAGENSLFM	RAD54L2	1306	Q9Y4B4
QMSFSQSPFLSIAKS	ANKRD12	1241	Q6UB98
MSYVFVNDSSQTNVP	ANKRD46	1	Q86W74
MNENLFASFIAPTIL	MT-ATP6	1	P00846
QNLNPLTPMAVAFFT	ATG2B	531	Q96BY7
LLFTNSPFQRDFMEQ	GRAMD1B	391	Q3KR37
ITLNKFFQPTEMASQ	AP2A2	821	O94973
SLSTPSLFANNNMEI	AP4E1	871	Q9UPM8
LSARDSVVLNFNPFM	CPT2	121	P23786
LSPDAVAQLAFQMAF	CPT2	461	P23786
FSVSPQAVYTAMLDN	R3HDM4	201	Q96D70
LINSFSMTTQNTGFP	RAD51AP2	666	Q09MP3
MAVANSSPVNPVVFF	PPIH	1	O43447
NDFLFVQATSSPMAL	HJV	196	Q6ZVN8
MSLSLFVLDQNDNAP	PCDHGA8	546	Q9Y5G5
TPSFNAMVVNNLTLQ	PARP9	306	Q8IXQ6
ESISQSNYPMVNSVF	LRRC9	566	Q6ZRR7
SELLQSVPSMFNFRA	MECOM	881	Q03112
NVQMFLQQPAVSLSF	NPAS2	541	Q99743
TASQMSLNSFINLPT	AOAH	276	P28039
NITQLSFQLISEPMF	OVOS1	161	Q6IE37
PQSIQESQNLSMFLA	CYFIP1	201	Q7L576
FLLNTNMVFQPSVKS	FHIP1B	781	Q8N612
PVSGILFNNMDDFSS	GGT3P	411	A6NGU5
NNTIHLNTMFFLSPA	OR8G5	16	Q8NG78
NAAVNPFFGSLMDVT	DHRS4L2	116	Q6PKH6
LMNVSEPNSSFAFVN	OR11H2	11	Q8NH07
LTNLMNQESTISFFP	OR2A14	81	Q96R47
TIIFMYLQPNSSQSV	OR5B21	251	A6NL26
GTLSFTPDFLQNVSM	KLHL36	176	Q8N4N3
QLPLRSFTANSDMAQ	KIAA0100	316	Q14667
NSAMRSVPNIFISNL	NMBR	71	P28336
NMNASKASQAVPTFL	MAGEL2	841	Q9UJ55
LNMNSAPTFINFPAK	MAGT1	131	Q9H0U3
VAFQNIPGSELMSSF	TMPO	446	P42166
FNDMFLSISTRLPSQ	MGAM2	1071	Q2M2H8
MQNSPSIAAAFLPTF	INTS1	2111	Q8N201
FMNLASDNLTNISLF	MMS22L	241	Q6ZRQ5
TQEMVSNFDLNSPLN	FYCO1	211	Q9BQS8
QASLMFFVQLPSNTT	INHBC	131	P55103
PFLSQFSFPQDITMV	ZFPM2	496	Q8WW38
RNNTDTFNFPDMLSL	LOXHD1	1726	Q8IVV2
GFLMVNAISNSEFQP	FSIP2	6286	Q5CZC0
LFFNLELSQMAAPAF	EXOSC9	76	Q06265
TNPNAMATIQSNTIF	PCK2	361	Q16822
PAINFDSAQNSMTKS	NEK10	46	Q6ZWH5
SLSPQFMLLSNITQF	OR51M1	6	Q9H341
LNKRSFFMISPTDQQ	PDPR	581	Q8NCN5
IFKNSQVPVQSSMSF	PDE6C	36	P51160
AVESEFLSQFNMTFP	CES2	101	O00748
MSDSNNFTTIAIPFG	HERC4	516	Q5GLZ8
ARSMLSNFAQAPQLS	GATAD2B	526	Q8WXI9
PQSIQESQNLSMFLA	CYFIP2	201	Q96F07
EATLLNMLNISPFSF	RPLP0	171	P05388
FANADPNFVTSMLTK	HCN4	596	Q9Y3Q4
PFFSSNPELDNLMIQ	MEIS3P2	121	A8K0S8
MPSQNYSIISEFNLF	OR10H4	1	Q8NGA5
NLAVSDFLMSFTQAP	OPN4	111	Q9UHM6
TLFEDSFQQIMSFSP	ITCH	556	Q96J02
FMPLQSLFTNALLND	ARHGAP29	256	Q52LW3
FSQAMASPAARDQFL	CCDC93	546	Q567U6
VAPAQTLSNAEFQML	CPS1	666	P31327
ISSEASLQMNSNYPA	CACNG5	246	Q9UF02
NDMATLFFNPQESAI	CLCN6	436	P51797
RSFLLNTNMVFQPSV	FHIP1A	891	Q05DH4
NFASSFAVSQAQMTP	HIKESHI	151	Q53FT3
ATMPLFANADPNFVT	HCN1	471	O60741
FANADPNFVTAMLSK	HCN1	476	O60741
RTTPIAMSFAQFENL	GPCPD1	541	Q9NPB8
PMVIAGQTANFSQFA	DOCK8	806	Q8NF50
FNPQSFLTAIMQSMA	DNAH17	4326	Q9UFH2
KSFVIQQIPSSNLFM	CACNA2D3	996	Q8IZS8
FANTNFVIIPNATPM	DEFB129	111	Q9H1M3
SMVQIFSFLPTNQLC	FBXL7	121	Q9UJT9
REQPQKTSMNTFTLF	FRMPD2	411	Q68DX3
LQMANTNFLSTLSPE	CXXC4	21	Q9H2H0
SNISPNFNFMGQLLD	DUSP7	366	Q16829
TFNVPALFISMQAVL	ACTR1A	131	P61163
AFIGNFAESIQMLTP	FMNL2	786	Q96PY5
NMAFSPFSIASLLTQ	SERPING1	166	P05155
FLLNSNAMDVVLQPS	GAA	311	P10253
PMTNSSIQFLDNAFR	GNS	276	P15586
PHLAFISNFTMTINN	ITIH6	76	Q6UXX5
QRDAATIMQPYFTSN	DYNC1H1	2416	Q14204
ETPMAQSDSQLFNQL	CUL9	631	Q8IWT3
NPQSFLTAIMQSTAR	DNAH9	4351	Q9NYC9
QTTLPAIVFQMFEQN	EXOC3	421	O60645
FIMPARTNNFNVETL	GYS1	366	P13807
SQIFLSMSDNFRPVQ	CA10	276	Q9NS85
NMSTSNKTRPFFDNL	SACS	3016	Q9NZJ4
MNDSRQQSLFFITLP	C18orf63	1	Q68DL7
SFQQMASPVFINISC	NUP210L	1761	Q5VU65
VLDQSPTVMFSSFKN	PRR14L	941	Q5THK1
LMNVSEPNSSFAFVN	OR11H1	11	Q8NG94
LMNVSEPNSSFAFVN	OR11H12	11	B2RN74
FIIPQMLSSFVTQTQ	OR10J6P	76	Q8NGY7
VMNSLDFPSFINLSN	CFAP221	156	Q4G0U5
MLTFSNNVEPANGFL	NAV1	1676	Q8NEY1
IAAPNLAFSQMVTTF	NNT	491	Q13423
LFNMQPLFSDVSVES	POLR1E	106	Q9GZS1
AVTQPNSSFFAGMLE	FNDC8	101	Q8TC99
ISNMRALENDFFNSP	RRN3	31	Q9NYV6
EATLLNMLNISPFSF	RPLP0P6	171	Q8NHW5
MTSFQEVPLQTSNFA	TAX1BP1	1	Q86VP1
QAENSLLQAAAAFPM	THADA	906	Q6YHU6
ATFALELSTYQAMNP	GFM2	751	Q969S9
SSPLQQMTFETSFQF	POLR1A	1666	O95602
PFSQDPTQLAEMIFN	STAT2	96	P52630
EMNFILSPSLDFVQS	TLR10	496	Q9BXR5
MNQFGPSALINLSNF	TAF12	1	Q16514
TLLMQEDAQFNFFPS	NEXMIF	326	Q5QGS0
LPANTMQLFLDNNSI	KERA	211	O60938
MSLNNSSNVFLDSVP	SLC12A1	1	Q13621
GFSNMVLSNLSPEAF	TAOK1	886	Q7L7X3
FLLNSNAMDVTFQPT	SI	1166	P14410
FNVNNLPFTEPMLSV	HERC2P3	981	Q9BVR0
FSQSGNPVMSTVAFL	SMARCC2	666	Q8TAQ2
TNNPNANLMLASASF	TBL1XR1	406	Q9BZK7
ALMDPTSLNQFVNTV	STK36	1041	Q9NRP7
LTSPQFQQALGMFSA	ADRM1	331	Q16186
FVPDISNSNSMIDAF	CLCA2	466	Q9UQC9
TRDSFPFDQQFNILM	CLASP1	966	Q7Z460
NPNSNIMLASASFDS	TBL1X	471	O60907
AYMEQSFQSLNPVLS	XYLT1	866	Q86Y38
PQLMTSQFISVFSNL	ZER1	606	Q7Z7L7
AMSLFQITFEINPLD	VPS13A	561	Q96RL7
FFNAVMQNLSQTPVL	USP16	206	Q9Y5T5
IFNMIFENPSLCASN	RGS12	146	O14924
NMNNTSDPTLAAIFE	TEP1	261	Q99973
SLCAQFAMDSLPVNQ	NME8	416	Q8N427
LMENAVFTFEQLLSP	NIBAN1	446	Q9BZQ8
DLENSFSNMLPFVPN	SLFN12L	96	Q6IEE8
ENSTFNALPALAAMQ	PROM2	351	Q8N271
NVFSTVPPAFINMAA	SAGE1	596	Q9NXZ1
FTEAQSLMASNPAVF	UROC1	361	Q96N76
FQLFNTSHMPVLAQD	STOX1	901	Q6ZVD7
NTPSMYSQELFQLSQ	SLMAP	156	Q14BN4
SMEIKSAQENPFLFS	THAP5	241	Q7Z6K1
MCPQESSFQPSQFLL	UNC5CL	1	Q8IV45
MNAVLQSLFAIPSFA	USP29	296	Q9HBJ7
QNYSMPTSSFRNLLE	PRAMEF10	186	O60809
QVLMSFPSLTNFLTE	STAB2	2316	Q8WWQ8
QQPLLSTQDFNMAAD	TOMM70	381	O94826
SNFNMTSLFPEIATA	USF3	2186	Q68DE3
ISNMRALENDFFNSP	RRN3P2	31	A6NIE6
QTTRYFNTPQTMDLF	NANOGP1	206	Q8N7R0
LDTNATMINSFNKFP	ZHX2	271	Q9Y6X8
SSSPVMLAFKSFQQE	TSNAX	31	Q99598
LSFDMASLINNPAFI	SGTB	211	Q96EQ0
ASLINNPAFISMAAS	SGTB	216	Q96EQ0
PFTEQIIQTFLNMFT	XPO6	856	Q96QU8
MIENHNISTPFSCQF	ZEB2	571	O60315
LTDMADFQQILQFPS	HIVEP2	1626	P31629
AEAIANMPASTFFAI	SLC6A4	411	P31645
MNFLNQLTSVFNPRT	UBR4	191	Q5T4S7
AVLANSFFIMPATVA	UBR4	276	Q5T4S7
NQANFSFAPLVLDML	UBR4	1801	Q5T4S7
ETMQNKFISSPFLAS	TASP1	321	Q9H6P5
QFISPQVSASMLKQF	TNRC6B	1231	Q9UPQ9
FQALNMEASPTALFS	VWA5B1	961	Q5TIE3
PRLAFATMFNSSEQS	GGT1	111	P19440
RFDIQMTQSPSFLSA	IGKV1D-42	21	A0A075B6H8
FDFSEAPMFTQPLVN	MYBPC1	1041	Q00872