Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin protein ligase activity

RNF114 ASB4 ARIH1 NFX1

1.38e-04372154GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

RNF114 ASB4 ARIH1 NFX1

1.78e-04398154GO:0061659
GeneOntologyMolecularFunctionacyltransferase activity

RNF114 EP300 ASB4 ARIH1 NFX1

1.89e-04775155GO:0016746
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

RNF114 ASB4 ARIH1 NFX1

3.45e-04473154GO:0004842
GeneOntologyMolecularFunctionzinc ion binding

RNF207 PAPPA EP300 ARIH1 NFX1

3.61e-04891155GO:0008270
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

RNF114 ASB4 ARIH1 NFX1

4.66e-04512154GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

RNF114 ASB4 ARIH1 NFX1

5.38e-04532154GO:0016755
GeneOntologyMolecularFunctiontransition metal ion binding

RNF207 PAPPA EP300 ARIH1 NFX1

1.35e-031189155GO:0046914
GeneOntologyBiologicalProcesspattern specification process

CHSY1 RNF207 BMP5 EP300 ERBB4

2.57e-05526155GO:0007389
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

ASB4 ARIH1

5.10e-0447152GO:0031462
HumanPhenoTalon cusp

CHSY1 EP300

1.39e-06432HP:0011087
HumanPhenoSupernumerary cusp

CHSY1 EP300

2.31e-06532HP:0033777
HumanPhenoAbnormality of the distal phalanx of the thumb

CHSY1 EP300

1.45e-043632HP:0009617
HumanPhenoShort hallux

CHSY1 EP300

1.62e-043832HP:0010109
HumanPhenoAplasia/Hypoplasia of the hallux

CHSY1 EP300

2.08e-044332HP:0008362
HumanPhenoHypoplasia of the toes

CHSY1 EP300

2.82e-045032HP:0004701
HumanPhenoAbnormal proximal phalanx morphology of the hand

CHSY1 EP300

3.05e-045232HP:0009834
HumanPhenoAbnormal incisor morphology

CHSY1 EP300

4.34e-046232HP:0011063
HumanPhenoShort metatarsal

CHSY1 EP300

4.34e-046232HP:0010743
HumanPhenoAplasia/Hypoplasia of metatarsal bones

CHSY1 EP300

4.92e-046632HP:0001964
HumanPhenoAplasia of the toes

CHSY1 EP300

6.19e-047432HP:0011306
HumanPhenoAbsent toe

CHSY1 EP300

6.19e-047432HP:0010760
HumanPhenoDeep philtrum

CHSY1 EP300

6.36e-047532HP:0002002
HumanPhenoCutaneous syndactyly

CHSY1 EP300

1.20e-0310332HP:0012725
HumanPhenoAbnormality of the incisor

CHSY1 EP300

1.32e-0310832HP:0000676
HumanPhenoShort toe

CHSY1 EP300

1.52e-0311632HP:0001831
HumanPhenoDeviation of toes

CHSY1 EP300

1.57e-0311832HP:0100498
HumanPhenoHypoplasia of the maxilla

CHSY1 EP300

1.91e-0313032HP:0000327
HumanPhenoAplasia/Hypoplasia of the maxilla

CHSY1 EP300

2.00e-0313332HP:0009117
HumanPhenoAplasia/Hypoplasia of toe

CHSY1 EP300

2.21e-0314032HP:0001991
HumanPhenoAbnormal maxilla morphology

CHSY1 EP300

2.81e-0315832HP:0000326
HumanPhenoAbnormal metatarsal morphology

CHSY1 EP300

2.85e-0315932HP:0001832
HumanPhenoMood alterations

EP300 ERBB4

3.03e-0316432HP:0001296
HumanPhenoPreaxial polydactyly

CHSY1 EP300

3.03e-0316432HP:0100258
HumanPhenoEmotional lability

EP300 ERBB4

3.03e-0316432HP:0000712
MousePhenoabsent trabeculae carneae

EP300 ERBB4

3.58e-0513102MP:0000296
MousePhenoabnormal tibia morphology

CHSY1 PAPPA BMP5 ARIH1

9.42e-05375104MP:0000558
MousePhenoabnormal hindlimb zeugopod morphology

CHSY1 PAPPA BMP5 ARIH1

1.00e-04381104MP:0003857
MousePhenoabsent myocardial trabeculae

EP300 ERBB4

1.06e-0422102MP:0000293
MousePhenoproportional dwarf

CHSY1 PAPPA

1.26e-0424102MP:0008974
MousePhenodecreased length of long bones

CHSY1 PAPPA BMP5 ARIH1

1.32e-04409104MP:0004686
MousePhenoabnormal limb long bone morphology

CHSY1 PAPPA BMP5 ARIH1

4.66e-04568104MP:0011504
MousePhenodecreased bone mineral density of femur

CHSY1 PAPPA

4.89e-0447102MP:0020010
MousePhenoabnormal hindlimb morphology

CHSY1 PAPPA BMP5 ARIH1

4.91e-04576104MP:0000556
MousePhenoabnormal limb bone morphology

CHSY1 PAPPA BMP5 ARIH1

5.28e-04587104MP:0002115
MousePhenoshort tibia

CHSY1 PAPPA ARIH1

8.07e-04274103MP:0002764
MousePhenoabnormal bone mineral density of femur

CHSY1 PAPPA

8.79e-0463102MP:0020009
MousePhenoabnormal long bone morphology

CHSY1 PAPPA BMP5 ARIH1

9.01e-04676104MP:0003723
MousePhenoabnormal kidney vasculature morphology

BMP5 ASB4

1.18e-0373102MP:0000530
MousePhenoabnormal trabecula carnea morphology

EP300 ERBB4

1.34e-0378102MP:0004067
DomainDUF4195

ZNF280A ZNF280B

3.61e-064152IPR025243
DomainDUF4195

ZNF280A ZNF280B

3.61e-064152PF13836
DomainZF_RING_1

RNF114 RNF207 ARIH1 NFX1

6.88e-05291154PS00518
DomainZF_RING_2

RNF114 RNF207 ARIH1 NFX1

7.55e-05298154PS50089
DomainRING

RNF114 RNF207 ARIH1 NFX1

8.26e-05305154SM00184
DomainZnf_RING

RNF114 RNF207 ARIH1 NFX1

1.07e-04326154IPR001841
Domainzf-C3HC4

RNF114 RNF207 NFX1

6.87e-04223153PF00097
DomainL_dom-like

ERBB4 MXRA5 LRRN4

2.09e-03328153IPR032675
DomainCys-rich_flank_reg_C

MXRA5 LRRN4

2.31e-0390152IPR000483
DomainLRRCT

MXRA5 LRRN4

2.31e-0390152SM00082
DomainZnf_C2H2-like

ZNF280A RNF114 RLF ZNF280B

3.07e-03796154IPR015880
DomainZnf_C2H2

ZNF280A RNF114 RLF ZNF280B

3.19e-03805154IPR007087
DomainZnF_C2H2

ZNF280A RNF114 RLF ZNF280B

3.24e-03808154SM00355
Domain-

RNF114 RNF207 ARIH1

5.06e-034491533.30.40.10
DomainZnf_RING/FYVE/PHD

RNF114 RNF207 ARIH1

5.38e-03459153IPR013083
DomainZnf_RING_CS

RNF114 RNF207

7.38e-03163152IPR017907
DomainLRR_8

MXRA5 LRRN4

8.09e-03171152PF13855
DomainZnf_C3HC4_RING-type

RNF114 RNF207

8.18e-03172152IPR018957
DomainLeu-rich_rpt_typical-subtyp

MXRA5 LRRN4

8.65e-03177152IPR003591
DomainLRR_TYP

MXRA5 LRRN4

8.65e-03177152SM00369
DomainLeu-rich_rpt

MXRA5 LRRN4

1.94e-02271152IPR001611
DomainZINC_FINGER_C2H2_2

ZNF280A RLF ZNF280B

2.23e-02775153PS50157
DomainZINC_FINGER_C2H2_1

ZNF280A RLF ZNF280B

2.24e-02777153PS00028
Domain-

MXRA5 LRRN4

2.67e-023211523.80.10.10
PathwayBIOCARTA_HER2_PATHWAY

EP300 ERBB4

1.14e-0423102MM1480
PathwayBIOCARTA_HER2_PATHWAY

EP300 ERBB4

1.14e-0423102M18719
Pubmed

TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1.

EP300 NFX1

1.58e-051415211331592
Pubmed

TRIB3‒GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target.

RNF114 ARIH1

2.65e-051815234729304
Pubmed

Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.

RNF114 ASB4 ARIH1

2.69e-0513815328786561
Pubmed

Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response.

RNF114 EP300 ARIH1

5.09e-0517115336629882
Pubmed

Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.

CHSY1 PAPPA

5.61e-052615233905568
Pubmed

A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice.

ZNF280B ERBB4

2.64e-045615220096683
Pubmed

Functional consequences of necdin nucleocytoplasmic localization.

RNF114 NFX1

3.45e-046415222442722
Pubmed

Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity.

PAPPA EP300

4.01e-046915232238831
InteractionUBE2D1 interactions

RNF114 RNF207 EP300 ASB4 ARIH1

1.70e-06294155int:UBE2D1
InteractionCCN2 interactions

EP300 ERBB4 ARIH1

3.24e-0640153int:CCN2
InteractionZNF280B interactions

ZNF280A ZNF280B

7.74e-066152int:ZNF280B
InteractionZNF280A interactions

ZNF280A ZNF280B

6.17e-0516152int:ZNF280A
Cytoband22q11.22

ZNF280A ZNF280B

2.51e-052315222q11.22
CytobandEnsembl 112 genes in cytogenetic band chr22q11

ZNF280A ZNF280B

8.07e-03419152chr22q11
GeneFamilyRing finger proteins

RNF114 RNF207

1.38e-0227512258
CoexpressionAtlasratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_500

PAPPA BMP5 ERBB4 MXRA5 LRRN4

1.17e-05498145PCBC_ratio_EB_vs_SC_500
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_1000

CHSY1 PAPPA BMP5 ERBB4 ASB4

9.61e-05773145gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_1000
CoexpressionAtlasDevelopingGonad_e11.5_ovary + mesonephros_emap-3226_top-relative-expression-ranked_1000

RNF114 RLF BMP5 ASB4 LRRN4

1.23e-04815145gudmap_developingGonad_e11.5_ovary + mesonephros_1000
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RNF207 PAPPA ERBB4 LRRN4

3.81e-071871548e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PAPPA BMP5 MXRA5

2.50e-05174153f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PAPPA BMP5 MXRA5

2.72e-05179153a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PAPPA BMP5 MXRA5

2.77e-05180153f2f6e83127a4a415e65c76a35efa8175fbd5b5d9
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA BMP5 LRRN4

2.91e-05183153ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PAPPA BMP5 MXRA5

3.15e-05188153997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

RNF207 PAPPA MXRA5

3.25e-051901534f775ee24b14733f06ae40b45f2dc1a0f0df0705
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PAPPA ERBB4 LRRN4

3.30e-051911534c4eb61e6179d2f8fc524d2f813db9cba84f67a2
ToppCellCOVID-19-kidney-CNT|kidney / Disease (COVID-19 only), tissue and cell type

CHSY1 ERBB4 MXRA5

3.35e-05192153d32ae226d95b4b6adb99d14b602be09b661d4cd9
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RNF207 PAPPA MXRA5

3.40e-05193153cd45118ced91b10baed3b1068d4673ec99824b86
ToppCellCOVID-19-kidney-CD-PC|kidney / Disease (COVID-19 only), tissue and cell type

PAPPA ERBB4 MXRA5

3.40e-05193153738689d009e4b118d7ce3171a207294b95cbe78b
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

PAPPA BMP5 MXRA5

3.40e-05193153cf2461af78f65616ce40d552ee9452295e3895ed
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo-stroma-adipo-CAR|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

PAPPA BMP5 MXRA5

3.40e-05193153e4ea7ce011a80b81b841c907719aa532bed39d2e
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RNF207 PAPPA MXRA5

3.40e-05193153adc9fc94f9ec686a417d08c0b8b7b7ab687afec0
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

PAPPA BMP5 MXRA5

3.40e-051931536ef9007c9d18fb775d08fb20cdf954a28d54d7eb
ToppCellControl-Fibroblasts-Intermediate_pathological_FB|Control / group, cell type (main and fine annotations)

PAPPA BMP5 MXRA5

3.46e-0519415303a269f75a481ea54aea8e6444605db8d6df493d
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAPPA BMP5 MXRA5

3.56e-0519615385e5046f774537684e1443c0fc147d562b7068d0
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PAPPA BMP5 MXRA5

3.56e-051961532ab9735aa7a7e95dcf6b0bdf0427f7b57f6349ee
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAPPA BMP5 MXRA5

3.56e-05196153e7bfd4fb400ae0c473131d0fa306c26be08a6d03
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAPPA BMP5 MXRA5

3.56e-0519615382fad623212d986a7fca3496faf3f8c8f5b83a11
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PAPPA BMP5 MXRA5

3.62e-051971535afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PAPPA BMP5 MXRA5

3.62e-05197153fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PAPPA BMP5 MXRA5

3.62e-051971531baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PAPPA BMP5 MXRA5

3.62e-05197153b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCellBronchial-10x5prime-Stromal-Mesofibroblastic-Mesothelia|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PAPPA MXRA5 LRRN4

3.62e-0519715326888af95a7cc082a1f1218af35b1f07cb9436ed
ToppCellCOVID-19-Fibroblasts-Intermediate_pathological_FB|COVID-19 / group, cell type (main and fine annotations)

PAPPA BMP5 MXRA5

3.62e-05197153f1c8936986123a3151140c374fcd62d6705c530b
ToppCellBronchial-10x5prime-Stromal-Mesofibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PAPPA MXRA5 LRRN4

3.62e-05197153438de7f0d35d81d5f5e41dcef7b2c54b6da03df4
ToppCell11.5-Airway-Mesenchymal-Mesenchyme_SERPINF1-high|Airway / Age, Tissue, Lineage and Cell class

RNF207 PAPPA MXRA5

3.62e-051971539a053a32ff9c3a85ef9a3382453acd619cc48546
ToppCell10x3'2.3-week_14-16-Mesenchymal_adipo-stroma-adipo-CAR|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PAPPA BMP5 MXRA5

3.67e-05198153a8c21f4db6730d0aa05b61fbe72bf9f7571a9015
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PAPPA BMP5 MXRA5

3.67e-051981537582ee9ec8a87ecb094201f1f9191b412f9d2875
ToppCell10x3'2.3-week_14-16-Mesenchymal_adipo-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PAPPA BMP5 MXRA5

3.67e-051981538b68fc887e5ad0a59ea4d93dfd1edda67030f142
ToppCell10x3'2.3-week_14-16-Mesenchymal_adipo|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PAPPA BMP5 MXRA5

3.67e-051981534739b2e4ab141c66772e61686b45614a1839483e
ToppCell10x5'v1-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PAPPA BMP5 MXRA5

3.73e-051991536200618e029063486719479c41eaf31798bd13cf
ToppCellstromal_cell|World / Lineage and Cell class

PAPPA BMP5 MXRA5

3.73e-05199153507a82d0529b5b1fa5aebcfe43db53f0b6e3f8f0
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PAPPA BMP5 MXRA5

3.73e-05199153e1f1950d6f840485e263b83dc81b98910be3ae7a
ToppCellstromal_cell-stromal_cell|World / Lineage and Cell class

PAPPA BMP5 MXRA5

3.73e-0519915374262363a34da3a1eb55ab375fd61ddd7bb39b23
ToppCell10x5'v1-week_14-16-Mesenchymal_adipo|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PAPPA BMP5 MXRA5

3.73e-05199153251b3643dcd8f4645b17101bd716e66f12a20e88
ToppCellILEUM-inflamed-(8)_Fibroblasts|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PAPPA BMP5 MXRA5

3.73e-051991533a3e2bb21cd0293622b1a975263e918d9ba24265
ToppCell10x5'v1-week_14-16-Mesenchymal_adipo-stroma-adipo-CAR|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PAPPA BMP5 MXRA5

3.73e-05199153117f4f43b6c06dda553799b1063e827bce697370
ToppCell10x5'v1-week_14-16-Mesenchymal_adipo-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PAPPA BMP5 MXRA5

3.73e-051991539b2262edbdec89166d895ab97527e0ee5f9b6010
ToppCellTracheal-10x3prime_v2-Stromal-Fibroblastic-Fibro_peribronchial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PAPPA BMP5 MXRA5

3.73e-05199153e9009eee7f77b9c9917f8e0e723001d9e76eb553
ToppCellILEUM-non-inflamed-(8)_Fibroblast-(8)_Fibroblasts|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PAPPA BMP5 MXRA5

3.73e-0519915356d72da6a5fab9cbb2975fe6f87a631debaba6a8
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PAPPA BMP5 MXRA5

3.79e-052001538ab0051544ea32eb8b3f7f8ba7582deaf8bf26c0
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PAPPA BMP5 MXRA5

3.79e-05200153fb53be20392a8309a7393774c774a1b1aec6e676
ToppCellParenchymal-10x5prime-Stromal-Fibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PAPPA BMP5 MXRA5

3.79e-052001536e3d1ae0ef84d3075afa40129a41169996462672
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-1|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

PAPPA BMP5 MXRA5

3.79e-0520015316a3685c41194a0a4a772e4eee372160263480e0
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PAPPA BMP5 MXRA5

3.79e-05200153ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCellCOVID-19_Mild-Neu_1|World / 5 Neutrophil clusters in COVID-19 patients

PAPPA ASB4

7.85e-04125152e58c208b4355252ceabe04a468dd19a1f436182c
ToppCellBronchial_Biopsy-Mesenchymal-Fibroblasts|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

PAPPA MXRA5

8.36e-0412915213cd10ffdd8f1ef7721884e9efd2cf25f170f414
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA ERBB4

8.62e-04131152d706405453408fbcfcabb1c7702b80f9e649ffca
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA MXRA5

1.05e-03145152fd02d55755c35288a42ab08a82450b370aad35a7
ToppCellLA-15._Ventricular_Cardiomyocyte_III|LA / Chamber and Cluster_Paper

ERBB4 MXRA5

1.08e-031471528970eb6b82589f39439c61a57d999661ec8342de
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PAPPA LRRN4

1.17e-0315315265641cc82883716dba0fefb749a30174a63f4da5
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF207 ERBB4

1.17e-031531523b1b0cc8e9dd2b1484649789330713282ee44414
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA ASB4

1.19e-03154152cd99428c282d566b5dbd31fd5a0371b7ffe9ffa2
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CHSY1 ASB4

1.22e-03156152895927228c93cd090303984c5be6ebfb59ed6f3a
ToppCellAdult-Mesenchymal-myofibroblast_cell-D122|Adult / Lineage, Cell type, age group and donor

PAPPA MXRA5

1.25e-03158152410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ERBB4 ASB4

1.26e-03159152e6ff9d2bce62bf9ea173af80b688eeb40fa4ea4c
ToppCellCOVID-CD4-CD4_Treg|COVID / Condition, Cell_class and T cell subcluster

EP300 ZNF280B

1.26e-03159152037cd97c41eb2f91fd3f69bbb3ffdfd6c0158410
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-5|TCGA-Stomach / Sample_Type by Project: Shred V9

ZNF280A LRRN4

1.26e-03159152c40fe552da3abdb1df87e9e1647468dc038bec0a
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA MXRA5

1.28e-031601527064af50fc10e3ea03badf415306222b74db0f95
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB4 ASB4

1.30e-031611523b5d7a3dab479c6959a428f3954dedd989900276
ToppCellAT1-AT2_cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

RNF207 PAPPA

1.31e-0316215257d627259d27f39885bf416d74bcb6656db6e27b
ToppCellnormal_Lung-Fibroblasts-Myofibroblasts|Fibroblasts / Location, Cell class and cell subclass

CHSY1 MXRA5

1.34e-031641529b4a6007abae992db871d9f6f731d5af724de30d
ToppCellBasal_cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

RNF207 MXRA5

1.38e-0316615223c04d1fba0c1733ccd0e4378fae2edde4fd0a7b
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF207 LRRN4

1.39e-031671523dfec2fcc36caa6e394efae5e540a6fa28759977
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF207 LRRN4

1.39e-031671529480739587d51e67a281778b9bddd7b5ffc3ad92
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF207 LRRN4

1.39e-0316715295b3b5ba3414729f0460a26a0deca48de0cbe33e
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB4 ASB4

1.41e-03168152f3879a8e11eaf866f37c52e67021be43f0b8784a
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4|TCGA-Lung / Sample_Type by Project: Shred V9

CHSY1 MXRA5

1.41e-03168152aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PAPPA MXRA5

1.43e-03169152c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 MXRA5

1.43e-03169152d161dd8eb22633392b6c6466ee9eff4042464149
ToppCellfacs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF207 ERBB4

1.48e-03172152bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCellfacs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF207 ERBB4

1.48e-03172152ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA LRRN4

1.49e-0317315230d67738633493d47f06ae452424382f069b6c0a
ToppCellwk_15-18-Mesenchymal-Fibroblast-Mesenchymal_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

RNF207 MXRA5

1.49e-03173152b43817a6b1ed8d6b5366702343be4311c0d52d83
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 MXRA5

1.51e-03174152fdadac1eaab2c4a67e4832f0901df22e893add6a
ToppCellTCGA-Adrenal-Primary_Tumor-Adrenocortical_carcinoma-Usual_Type-4|TCGA-Adrenal / Sample_Type by Project: Shred V9

CHSY1 ASB4

1.51e-0317415215e2b9f46404ff9575e149024b24cb17b50b02b5
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PAPPA ERBB4

1.51e-03174152cc4c7f00a25a7814b52d4599166615daa140cc31
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA LRRN4

1.51e-03174152a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCellfacs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP5 ASB4

1.53e-03175152d8e385320f554d974538b7cdc4f8e4767f1455f2
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CHSY1 RNF207

1.53e-03175152334fad1a147de6c007cec5089c02c35cf3220f1b
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

CHSY1 RNF207

1.53e-03175152da191dfb8a7f976a632a3a0b923942ab54f5c8c1
ToppCellfacs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP5 ASB4

1.53e-03175152cf15465855602ba135752c18755e3e058dbd42ec
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122|Adult / Lineage, Cell type, age group and donor

ERBB4 ASB4

1.55e-031761523fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)|390C / Donor, Lineage, Cell class and subclass (all cells)

BMP5 MXRA5

1.55e-03176152852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PAPPA ERBB4

1.55e-03176152682a1dfcc507ec540f5fadf08e872533ea9f0291
ToppCellwk_08-11-Mesenchymal-Chondrocyte|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

BMP5 MXRA5

1.55e-031761521af28b701c4598ce761f85adbd5d79e4918d265a
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

PAPPA MXRA5

1.55e-03176152bfa1633e1b7a8a2f04d37fa07284fe9bc0199f46
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|390C / Donor, Lineage, Cell class and subclass (all cells)

BMP5 MXRA5

1.55e-03176152d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|356C / Donor, Lineage, Cell class and subclass (all cells)

BMP5 MXRA5

1.56e-03177152cdfd2f0ee2f692271b1525e414b0f645cdadb1f6
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

PAPPA MXRA5

1.56e-031771523d955ea938a1d2fb1b6d68d4997fd454bd632dfc
ToppCell5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BMP5 MXRA5

1.56e-03177152e65c0568dc5852108e9802273499bc7cf88fafab
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)|356C / Donor, Lineage, Cell class and subclass (all cells)

BMP5 MXRA5

1.56e-03177152db222faaecbe5600da39277243c4e7e764eb63c9
ToppCell356C-Fibroblasts-Fibroblast-G-|356C / Donor, Lineage, Cell class and subclass (all cells)

BMP5 MXRA5

1.56e-031771527617270f49cd6b7ba66db72d20560cee985012b2
ToppCell356C-Fibroblasts-Fibroblast-G|356C / Donor, Lineage, Cell class and subclass (all cells)

BMP5 MXRA5

1.56e-031771528220cc2fc0ee8764a67a3be51d75248be2453040
ToppCellILEUM-inflamed-(9)_Enteric_neurons|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PAPPA ASB4

1.58e-03178152d9142151819afb0dc22bfb32a9c9dba5f553067d
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PAPPA ERBB4

1.58e-031781526ad46b0720298bcb927fd53468bb4ea0c199ad35
ToppCellILEUM-inflamed-(9)_Neuro_cell|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PAPPA ASB4

1.58e-03178152611504b0a9e6318b18fba83787b03f9245c82252
ToppCell10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

PAPPA MXRA5

1.58e-031781528f31b3fac51591f7f2bcb898c07708b3e9f93a16
DrugEthoxyquin [91-53-2]; Up 200; 18.4uM; PC3; HT_HG-U133A

ZNF280A PAPPA BMP5 ZNF280B

7.17e-061991543764_UP
Diseaseirritable bowel syndrome

EP300 ERBB4 ASB4

3.74e-05131153EFO_0000555
DiseaseBreast adenocarcinoma

EP300 ERBB4

1.96e-0441152C0858252
DiseaseNeoplasm of uncertain or unknown behavior of breast

EP300 ERBB4

1.96e-0441152C0496956
Diseasehippocampal CA1 volume

CHSY1 PAPPA

2.68e-0448152EFO_0009394
Diseaseintellectual disability (implicated_via_orthology)

ZNF280A ZNF280B

6.55e-0475152DOID:1059 (implicated_via_orthology)
Diseaseosteoarthritis, hip

BMP5 EP300

9.83e-0492152EFO_1000786
DiseaseAdenocarcinoma of large intestine

EP300 ERBB4

1.07e-0396152C1319315
Diseasecolorectal cancer (is_implicated_in)

EP300 ERBB4

1.69e-03121152DOID:9256 (is_implicated_in)
Diseasesmoking behavior, body mass index

ERBB4 ASB4

1.75e-03123152EFO_0004318, EFO_0004340
Diseaseautism spectrum disorder (implicated_via_orthology)

ZNF280A ZNF280B

2.65e-03152152DOID:0060041 (implicated_via_orthology)
Diseaseprostate cancer (is_marker_for)

EP300 ERBB4

2.79e-03156152DOID:10283 (is_marker_for)
Diseaseheart failure

ZNF280A RNF207

3.89e-03185152EFO_0003144
Diseasealcohol use disorder (implicated_via_orthology)

EP300 ERBB4

4.31e-03195152DOID:1574 (implicated_via_orthology)
Diseasemelanoma

EP300 ERBB4

6.87e-03248152C0025202
Diseaseage at menopause

RNF114 LRRN4

1.00e-02302152EFO_0004704

Protein segments in the cluster

PeptideGeneStartEntry
HHKPGEMPYVCQVCH

ZNF280A

386

P59817
HKPGEMPYVCQVCHY

ZNF280B

396

Q86YH2
KYADPDRECHPCHPN

ERBB4

606

Q15303
YHAKHCQENKCPVPF

EP300

1791

Q09472
PPQFHKVIQACHSCP

ASB4

321

Q9Y574
CPAPDCHHVVKVQYP

ARIH1

276

Q9Y4X5
PVYHSCHSEEKCPPC

NFX1

781

Q12986
YPHPALIHCVKGCEP

PAPPA

1546

Q13219
VHLMFPDHVPKPCCA

BMP5

406

P22003
PHQDVPCDYHPCKHL

LRRN4

541

Q8WUT4
PCDYHPCKHLQTPCA

LRRN4

546

Q8WUT4
HPLVCPLCHVQYERP

RNF207

21

Q6ZRF8
HHPVFCDPNLDPKQY

CHSY1

746

Q86X52
EHEQVHCGPQPYMCV

RLF

731

Q13129
YEKPVQVPCGHVFCS

RNF114

36

Q9Y508
ACPHPCACYVPSEVH

MXRA5

26

Q9NR99