Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainDUF4704

WDFY3 LRBA

1.26e-045672IPR031570
DomainDUF4704

WDFY3 LRBA

1.26e-045672PF15787
DomainPH_BEACH

WDFY3 LRBA

1.88e-046672PF14844
DomainPH-BEACH_dom

WDFY3 LRBA

3.50e-048672IPR023362
Domain-

WDFY3 LRBA

3.50e-0486722.30.29.40
DomainPH_BEACH

WDFY3 LRBA

3.50e-048672PS51783
DomainBEACH_dom

WDFY3 LRBA

4.49e-049672IPR000409
DomainBEACH

WDFY3 LRBA

4.49e-049672PS50197
DomainBeach

WDFY3 LRBA

4.49e-049672PF02138
Domain-

WDFY3 LRBA

4.49e-0496721.10.1540.10
DomainBeach

WDFY3 LRBA

4.49e-049672SM01026
DomainJAB_MPN

PRPF8 PSMD14

8.18e-0412672SM00232
DomainJAMM/MPN+_dom

PRPF8 PSMD14

8.18e-0412672IPR000555
DomainFAD-dep_OxRdtase

GPD2 DMGDH

8.18e-0412672IPR006076
DomainDAO

GPD2 DMGDH

8.18e-0412672PF01266
DomainJAB

PRPF8 PSMD14

8.18e-0412672PF01398
DomainDAPIN

NLRP9 NLRP14

2.80e-0322672PS50824
DomainPYRIN

NLRP9 NLRP14

2.80e-0322672PF02758
DomainDAPIN

NLRP9 NLRP14

2.80e-0322672IPR004020
DomainPYRIN

NLRP9 NLRP14

2.80e-0322672SM01289
DomainNACHT

NLRP9 NLRP14

3.06e-0323672PS50837
DomainNACHT_NTPase

NLRP9 NLRP14

3.06e-0323672IPR007111
DomainPH_dom-like

PSD DOCK9 WDFY3 LRBA TNS1 ANKS1A

4.20e-03426676IPR011993
Pubmed

PPARδ activation attenuates hepatic steatosis in Ldlr-/- mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity.

PRKAB1 PPARD

1.13e-05368224864274
Pubmed

VDR-SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment.

PPARD VDR

1.13e-05368232900990
Pubmed

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice.

UNC93B1 LRBA

1.13e-05368231097594
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

GPD2 UTP18 ADSS2 NUP155 NANP STAU2 SMARCA2 TMED10 PRPF8 CDC27 PSMD14 RAB13

1.23e-051367681232687490
Pubmed

The human peroxisome proliferator-activated receptor delta gene is a primary target of 1alpha,25-dihydroxyvitamin D3 and its nuclear receptor.

PPARD VDR

2.25e-05468215890193
Pubmed

Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise.

PRKAB1 CPT1A

2.25e-05468227941154
Pubmed

Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction.

PPARD CPT1A

2.25e-05468226253087
Pubmed

Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system.

CNTN4 CNTN3

3.75e-05568218272596
Pubmed

Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.

CNTN4 CNTN3

3.75e-05568227539848
Pubmed

The metabolite GnRH-(1-5) inhibits the migration of immortalized GnRH neurons.

GPR173 GPR119

3.75e-05568223321696
Pubmed

Proteinase-activated receptors, nucleotide P2Y receptors, and μ-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.

TMED10 F2RL1

3.75e-05568221219331
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

CERS2 PPP2R5C CEP112 DOCK9 CEP295 PSMD10 CDC27 TNS1 ULK2 NT5DC1

4.68e-051084681011544199
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

UTP18 STAU2 H1-6 SMARCA2 LRBA TMED10 PRPF8 CDC27 PSMD14 RAB13 DARS2

4.68e-051318681130463901
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

GPD2 ADSS2 NUP155 CARS1 H1-6 PSMD10 LRBA PRPF8 NT5DC1

5.20e-0587868937223481
Pubmed

The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2.

PRKAB1 PPARD

5.62e-05668222135324
Pubmed

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14.

BECN1 ULK2

5.62e-05668227046250
Pubmed

PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression.

PSMD10 BECN1

5.62e-05668225905985
Pubmed

High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity.

PPARD CPT1A

5.62e-05668234107251
Pubmed

HIV-1 Vpr enhances PPARβ/δ-mediated transcription, increases PDK4 expression, and reduces PDC activity.

PPARD CPT1A

7.86e-05768223842279
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

GNPDA1 NUP155 TMED10 CDC27 PSMD14 DARS2 POLR3C

8.35e-0553468735032548
Pubmed

Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity.

CNTN4 NANP WDFY3 LRBA GPR119 ANKS1A

9.27e-0537468623824909
Pubmed

Chaperone-mediated pathway of proteasome regulatory particle assembly.

PSMD10 PSMD14

1.05e-04868219412159
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

GPD2 PPP2R5C UTP18 NUP155 STAU2 PRPF8 CDC27

1.12e-0456068735241646
Pubmed

Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome.

PSMD10 PSMD14

1.34e-04968219349277
Pubmed

Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators.

PPARD VDR

1.34e-04968215888456
Pubmed

Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.

PPARD VDR

1.34e-04968228751364
Pubmed

Age-associated alteration of gene expression patterns in mouse oocytes.

NLRP9 NLRP14 SMARCA2

1.39e-045168315317747
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

UTP18 NUP155 USP38 TAF1A SMARCA2 PSMD10 PRPF8 CDC27 PSMD14

1.45e-04100568919615732
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

CERS2 NUP155 CEP112 CARS1 TMED10 CPT1A PRPF8 CDC27 RAB13 DARS2

2.04e-041297681033545068
Pubmed

Autophagy is required for lung development and morphogenesis.

PRKAB1 BECN1

2.05e-041168231162135
Pubmed

Mammalian Cdh1/Fzr mediates its own degradation.

PSMD10 CDC27 PSMD14

2.15e-045968315029244
Pubmed

Network organization of the human autophagy system.

ADSS2 NUP155 PRKAB1 CPT1A BECN1 ULK2

2.16e-0443768620562859
Pubmed

A role for Nr-CAM in the patterning of binocular visual pathways.

CNTN4 CNTN3

2.45e-041268216701205
Pubmed

NODs: intracellular proteins involved in inflammation and apoptosis.

NLRP9 NLRP14

2.45e-041268212766759
Pubmed

Mitochondrial Raf1 Regulates Glutamine Catabolism.

GPD2 UNC93B1 ASB2 CPT1A TNS1

2.56e-0428868538496616
Pubmed

The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.

NUP155 H1-6 SMARCA2 CEP295 PSMD10 CPT1A

2.61e-0445368627113764
Pubmed

Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy.

GNPDA1 UTP18 ADSS2 RAB13 DARS2

2.73e-0429268535545034
Pubmed

Pioneering axons regulate neuronal polarization in the developing cerebral cortex.

CNTN4 CNTN3

2.90e-041368224559674
Pubmed

Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.

PSMD10 CDC27 PSMD14

3.13e-046768311285280
Pubmed

The genetics of NOD-like receptors in Crohn's disease.

NLRP9 NLRP14

3.38e-041468220403135
Pubmed

NALPs: a novel protein family involved in inflammation.

NLRP9 NLRP14

3.38e-041468212563287
Pubmed

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.

PSMD10 CPT1A PSMD14

3.71e-047168323503661
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

GNPDA1 PPP2R5C CARS1 PRPF8 DARS2 ANKS1A

4.32e-0449868636634849
Pubmed

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.

GPD2 CERS2 UNC93B1 TMED10 CPT1A PSMD14

4.37e-0449968622810586
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

GPD2 CERS2 UTP18 ADSS2 NUP155 STAU2 UNC93B1 TMED10 PRPF8 PSMD14

4.68e-041440681030833792
Pubmed

Evolutionarily conserved regulators of tau identify targets for new therapies.

ADSS2 NUP155 PSMD10 LRBA TMED10 PSMD14

5.21e-0451668636610398
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

CERS2 UTP18 NUP155 LRBA TMED10 PRPF8 RAB13 DARS2

5.30e-0495268838569033
Pubmed

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.

PRKAB1 CPT1A

5.65e-041868216054041
Pubmed

RNF115 Inhibits the Post-ER Trafficking of TLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination of RAB1A and RAB13.

UNC93B1 RAB13

6.30e-041968235343654
Pubmed

A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.

CFAP47 GPR173

7.00e-042068219377476
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

GPN2 DOCK9 TAF1A STAU2 TNS1

7.33e-0436368514691545
Pubmed

Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing.

PRPF8 VDR

7.72e-042168212840015
Pubmed

NSP6 inhibits the production of ACE2-containing exosomes to promote SARS-CoV-2 infectivity.

CERS2 PSMD14

8.48e-042268238303107
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

GPD2 CERS2 ADSS2 LRBA CPT1A PRPF8 PSMD14

1.00e-0380768730575818
Pubmed

Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.

WDFY3 ANKS1A

1.01e-032468217452356
Pubmed

A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.

PRPF8 CDC27

1.01e-032468233705438
Pubmed

Phosphatase UBLCP1 controls proteasome assembly.

PSMD10 PSMD14

1.01e-032468228539385
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

UTP18 ADSS2 NUP155 SMARCA2 WDFY3 PRPF8 CDC27 NT5DC1 RAB13

1.24e-03135368929467282
Pubmed

Phospho-tyrosine dependent protein-protein interaction network.

WDFY3 PPARD BECN1 TNS1 ANKS1A

1.26e-0341068525814554
Pubmed

Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism.

PPARD CPT1A

1.28e-032768224086110
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

UTP18 NUP155 STAU2 CARS1 SMARCA2 PRPF8

1.29e-0361568631048545
Pubmed

Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome.

TRIM2 ST8SIA6

1.38e-032868224427155
Pubmed

Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.

PPARD TNS1

1.48e-032968221998595
Pubmed

USP14 is a deubiquitinase for Ku70 and critical determinant of non-homologous end joining repair in autophagy and PTEN-deficient cells.

PSMD10 PSMD14

1.58e-033068231740976
Pubmed

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.

PSMD10 PSMD14

1.91e-033368223751493
Pubmed

Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart.

BECN1 ULK2

1.91e-033368222904094
GeneFamilyWD repeat domain containing|BEACH domain containing

WDFY3 LRBA

2.35e-0494721230
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

NLRP9 NLRP14

1.91e-0325472994
GeneFamilyNLR family

NLRP9 NLRP14

1.91e-0325472666
GeneFamilyAutophagy related

BECN1 ULK2

3.32e-03334721022
GeneFamilyAnkyrin repeat domain containing

PSMD10 ASB2 INVS ANKS1A

3.56e-03242474403
GeneFamilyProteasome

PSMD10 PSMD14

5.58e-0343472690
GeneFamilyNuclear hormone receptors

PPARD VDR

7.20e-034947271
GeneFamilyFibronectin type III domain containing

CNTN4 PRTG CNTN3

8.29e-03160473555
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

CNTN4 PRTG CNTN3

8.44e-03161473593
CoexpressionNAKAYA_MYELOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP

GPD2 NUP155 CEP112 STAU2 ULK2 PAQR3 ANKS1A POLR3C

4.81e-06378668M41174
CoexpressionGSE3982_NEUTROPHIL_VS_EFF_MEMORY_CD4_TCELL_DN

UTP18 NUP155 PPARD CPT1A CYP39A1 POLR3C

1.10e-05199666M5527
Diseaseesophagus adenocarcinoma (is_marker_for)

BECN1 VDR

3.11e-0412652DOID:4914 (is_marker_for)
Diseasetriglycerides:total lipids ratio, low density lipoprotein cholesterol measurement

DMGDH BANF2 LRBA CPT1A

3.41e-04150654EFO_0004611, EFO_0020947
Diseasepeak expiratory flow

DMGDH DOCK9 STAU2 PPARD VDR ANKS1A

7.98e-04498656EFO_0009718
Diseaselow density lipoprotein cholesterol measurement, alcohol consumption measurement

TRIM2 BANF2 NT5DC1

1.38e-0399653EFO_0004611, EFO_0007878
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

DMGDH BANF2 LRBA CPT1A

1.47e-03222654EFO_0008317, EFO_0020943
Diseaselow density lipoprotein cholesterol measurement, alcohol drinking

TRIM2 BANF2 NT5DC1

1.50e-03102653EFO_0004329, EFO_0004611
Diseasetriglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

DMGDH BANF2 LRBA CPT1A

1.55e-03225654EFO_0008317, EFO_0020947
Diseasephospholipids:total lipids ratio

CERS2 DMGDH PSD BANF2

1.60e-03227654EFO_0020946
Diseasealkaline phosphatase measurement

PPP2R5C TRIM2 BANF2 PPARD LRBA CPT1A NT5DC1 TXNDC11

1.70e-031015658EFO_0004533
Diseasetriacylglycerol 54:7 measurement

CNTN4 TXNDC11

1.74e-0328652EFO_0010425
Diseasevery low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

CERS2 DMGDH BANF2 CPT1A

3.91e-03291654EFO_0008317, EFO_0020946

Protein segments in the cluster

PeptideGeneStartEntry
SHLLYAKMIQKLADL

VDR

376

P11473
LYKKLNTHVALVGME

ADAM28

241

Q9UKQ2
LHIASKKGNYRIVQM

ASB2

341

Q96Q27
YAKLLLHMLKRGALE

CEP112

66

Q8N8E3
LMIRNIQLKHAGKYV

CNTN4

561

Q8IWV2
QLALQLAHYKDMGKF

CPT1A

571

P50416
IHGLIYNALKLFMEM

PPP2R5C

386

Q13362
LYGRLEVVKMLLNAH

ANKS1A

191

Q92625
LMKIEYLAQGKNHRI

ADCY10

526

Q96PN6
YLILRMAHKFITGKL

CERS2

321

Q96G23
MAKAYDHLFKLLLIG

RAB13

1

P51153
MHQKLLKSAHYIELG

PAQR3

1

Q6TCH7
SQGNAVHLYELLKKM

NT5DC1

286

Q5TFE4
HGGVRYLQKAIMKLD

GPD2

116

P43304
LLSKMDLIEHYGKLA

GPN2

176

Q9H9Y4
KGLMLVHNKLVDPLY

GNPDA1

256

P46926
VLLLHALANKMGLKF

BECN1

311

Q14457
ILLGNGMLLYLIKHD

OR51B2

36

Q9Y5P1
MILLNNSHKLLALYK

GLYATL1

1

Q969I3
VRLQLYHMALGVKKV

GPR119

286

Q8TDV5
RGMLEVIKLLQSKYH

NANP

26

Q8TBE9
RVQALKAMGYFLKHL

LRBA

736

P50851
MHALSLKIVLLGKIY

NUP155

1241

O75694
SYMHILGAILKIQTK

OR2A2

216

Q6IF42
MNKYGAILSQKAHLA

PRTG

116

Q2VWP7
KKHPAVIYMANLALA

F2RL1

106

P55085
MSLVALKKALAAAGY

H1-6

61

P22492
GNELVKYLKSLHAME

DOCK9

846

Q9BZ29
NKAYILLGQFLLMHK

BANF2

41

Q9H503
LMAATHAVYGKLLLF

GPR173

196

Q9NS66
YHLAKAGMKDVVLLE

DMGDH

66

Q9UI17
VFLALHEKLYIMLKG

CYP39A1

111

Q9NYL5
MKHVLNLYLLGVVLT

HILPDA

1

Q9Y5L2
MIYLKSSENLKHGAL

FAM237A

76

A0A1B0GTK4
MYNADRKVKGNLILH

CEP295

311

Q9C0D2
VYKKLGQTHLALMNF

CDC27

746

P30260
NKTIYDVLLHLSGKM

CFAP47

1591

Q6ZTR5
DLMIRNIQLKHSGKY

CNTN3

561

Q9P232
YENHSAIMLGIKKEL

OLFML2A

181

Q68BL7
VYISSLALLKMLKHG

PSMD14

31

O00487
AAAKGNLKMIHILLY

PSMD10

146

O75832
HLAAQKGNYRFMKLL

INVS

86

Q9Y283
AHMGAIKAISYFLIL

TAS2R39

256

P59534
IAGYLHLLAMKTKEL

UTP18

361

Q9Y5J1
VKMLSHLLQALDYGA

DARS2

561

Q6PI48
NIALYLTHMLKIFGA

CARS1

546

P49589
FHGILKGMILYLQKE

PSD

786

A5PKW4
SALQKILYRHMQAKG

SMARCA2

971

P51531
LYLNGNHLTKLSKGM

SLITRK6

416

Q9H5Y7
LSKGMFLGLHNLEYL

SLITRK6

426

Q9H5Y7
LLKYGVHEAIFAMLA

PPARD

281

Q03181
ALYLLHHGMLKDAKR

TAF1A

141

Q15573
YLAKYLKNILMGNHL

TAF1A

351

Q15573
YSQILQLHMKGILKL

ST8SIA6

376

P61647
LDLVLLKYAHMINGF

ADSS2

341

P30520
LKYAHMINGFTALAL

ADSS2

346

P30520
LNHLYALSIKDGVMV

PRKAB1

236

Q9Y478
AIQGIKDLHAYQMAK

APOL5

236

Q9BWW9
LLIALGKLAMQKHYF

NLRP9

271

Q7RTR0
ALKYMPHAVLKLLEN

PRPF8

91

Q6P2Q9
YLGSSLHMKAKLAVL

UNC93B1

486

Q9H1C4
LEVMVNLLHKYAALL

WDFY3

506

Q8IZQ1
GGMYVINLHKALASL

POLR3C

331

Q9BUI4
AKKNAAEAMLLQLGY

STAU2

361

Q9NUL3
LVILDMKHGVEAKNY

TMED10

121

P49755
MLKSKHGGNYLLFNL

TNS1

46

Q9HBL0
VAILDYIHNGLKLIM

USP38

101

Q8NB14
HYILDPKQALMKLTL

TXNDC11

646

Q6PKC3
VLYMKAAQLLAASLH

ULK2

886

Q8IYT8
VLLMELEVNYGLKHK

TRIM2

221

Q9C040
KQLLKNHHYVELLGM

NLRP14

316

Q86W24