Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	CYP2E1 COQ6 NOS1 NOS2	2.73e-05	40	87	4	GO:0016709
GeneOntologyMolecularFunction	nitric-oxide synthase activity	NOS1 NOS2	5.61e-05	3	87	2	GO:0004517
GeneOntologyMolecularFunction	tetrahydrobiopterin binding	NOS1 NOS2	1.12e-04	4	87	2	GO:0034617
GeneOntologyMolecularFunction	pyrophosphatase activity	IFIH1 SMCHD1 BMS1 GNAI2 GNAT1 NUDT9 GFM1 DNAH5 DYNC1H1 RGS13 NLRP3 EFTUD2	2.74e-04	839	87	12	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	IFIH1 SMCHD1 BMS1 GNAI2 GNAT1 NUDT9 GFM1 DNAH5 DYNC1H1 RGS13 NLRP3 EFTUD2	2.77e-04	840	87	12	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IFIH1 SMCHD1 BMS1 GNAI2 GNAT1 NUDT9 GFM1 DNAH5 DYNC1H1 RGS13 NLRP3 EFTUD2	2.77e-04	840	87	12	GO:0016818
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	IFIH1 SMCHD1 BMS1 GNAI2 GNAT1 GFM1 DNAH5 DYNC1H1 RGS13 NLRP3 EFTUD2	5.35e-04	775	87	11	GO:0017111
GeneOntologyMolecularFunction	arginine binding	NOS1 NOS2	6.62e-04	9	87	2	GO:0034618
GeneOntologyBiologicalProcess	regulation of protein secretion	ORAI1 BMP6 AHI1 SLC12A2 DPH3 C1QTNF3 NOS1 NOS2 EPHA5	1.04e-05	350	82	9	GO:0050708
GeneOntologyBiologicalProcess	regulation of secretion by cell	ORAI1 BMP6 VPS18 SNX4 AHI1 SLC12A2 DPH3 C1QTNF3 GNAI2 NOS1 NOS2 EPHA5	3.45e-05	740	82	12	GO:1903530
GeneOntologyBiologicalProcess	regulation of secretion	ORAI1 BMP6 VPS18 SNX4 AHI1 SLC12A2 DPH3 C1QTNF3 GNAI2 NOS1 NOS2 EPHA5	7.39e-05	801	82	12	GO:0051046
GeneOntologyBiologicalProcess	regulation of protein transport	ORAI1 BMP6 AHI1 SLC12A2 DPH3 C1QTNF3 XPO1 NOS1 NOS2 EPHA5	7.43e-05	560	82	10	GO:0051223
GeneOntologyBiologicalProcess	protein secretion	ORAI1 BMP6 AHI1 SLC12A2 DPH3 C1QTNF3 NOS1 NOS2 EPHA5	1.21e-04	480	82	9	GO:0009306
GeneOntologyBiologicalProcess	establishment of protein localization to extracellular region	ORAI1 BMP6 AHI1 SLC12A2 DPH3 C1QTNF3 NOS1 NOS2 EPHA5	1.27e-04	483	82	9	GO:0035592
GeneOntologyBiologicalProcess	protein localization to extracellular region	ORAI1 BMP6 AHI1 SLC12A2 DPH3 C1QTNF3 NOS1 NOS2 EPHA5	1.41e-04	490	82	9	GO:0071692
GeneOntologyBiologicalProcess	regulation of cyclase activity	ORAI1 GNAI2 NOS1 NOS2	1.65e-04	69	82	4	GO:0031279
GeneOntologyBiologicalProcess	sodium ion import across plasma membrane	SLC12A2 SCN5A HCN2	1.65e-04	27	82	3	GO:0098719
GeneOntologyBiologicalProcess	regulation of lyase activity	ORAI1 GNAI2 NOS1 NOS2	2.05e-04	73	82	4	GO:0051339
GeneOntologyBiologicalProcess	positive regulation of guanylate cyclase activity	NOS1 NOS2	2.32e-04	6	82	2	GO:0031284
GeneOntologyCellularComponent	dynein complex	SNX4 DNAI7 CCDC65 DNAH5 DYNC1H1	2.67e-06	54	85	5	GO:0030286
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	DST IFT57 GRIK2 DNAI7 CCDC65 DNAH5 DYNC1H1 TRAK1	4.47e-05	317	85	8	GO:0032838
GeneOntologyCellularComponent	cytoplasmic region	DST IFT57 GRIK2 DNAI7 CCDC65 DNAH5 DYNC1H1 TRAK1	1.09e-04	360	85	8	GO:0099568
GeneOntologyCellularComponent	axonemal dynein complex	DNAI7 CCDC65 DNAH5	1.40e-04	25	85	3	GO:0005858
GeneOntologyCellularComponent	microtubule associated complex	SNX4 DNAI7 CCDC65 DNAH5 DYNC1H1	5.09e-04	161	85	5	GO:0005875
GeneOntologyCellularComponent	photoreceptor connecting cilium	AHI1 IFT57 GNAT1	9.83e-04	48	85	3	GO:0032391
GeneOntologyCellularComponent	neuron projection cytoplasm	DST GRIK2 DYNC1H1 TRAK1	1.06e-03	110	85	4	GO:0120111
GeneOntologyCellularComponent	neuron to neuron synapse	SORT1 DST PTPRO DROSHA GRIK2 GNAI2 TACC3 NOS1	1.30e-03	523	85	8	GO:0098984
GeneOntologyCellularComponent	microbody lumen	ACOT2 NOS2 GNPAT	1.46e-03	55	85	3	GO:0031907
GeneOntologyCellularComponent	peroxisomal matrix	ACOT2 NOS2 GNPAT	1.46e-03	55	85	3	GO:0005782
Domain	-	NOS1 NOS2	5.84e-05	3	83	2	3.90.340.10
Domain	CRAC_channel	ORAI1 ORAI3	5.84e-05	3	83	2	IPR012446
Domain	NO_synthase	NOS1 NOS2	5.84e-05	3	83	2	PF02898
Domain	ZF_DPH	DPH3 DPH3P1	5.84e-05	3	83	2	PS51074
Domain	NOS_N	NOS1 NOS2	5.84e-05	3	83	2	IPR004030
Domain	Znf_DHP	DPH3 DPH3P1	5.84e-05	3	83	2	IPR007872
Domain	NOS	NOS1 NOS2	5.84e-05	3	83	2	PS60001
Domain	NOS_euk	NOS1 NOS2	5.84e-05	3	83	2	IPR012144
Domain	zf-CSL	DPH3 DPH3P1	5.84e-05	3	83	2	PF05207
Domain	Orai-1	ORAI1 ORAI3	5.84e-05	3	83	2	PF07856
Domain	TF_GTP-bd_dom	BMS1 GFM1 EFTUD2	7.79e-05	19	83	3	IPR000795
Domain	EFG_IV	GFM1 EFTUD2	1.16e-04	4	83	2	SM00889
Domain	EFG_IV	GFM1 EFTUD2	1.16e-04	4	83	2	PF03764
Domain	Transl_elong_EFG/EF2_IV	GFM1 EFTUD2	1.16e-04	4	83	2	IPR005517
Domain	EFG_II	GFM1 EFTUD2	1.93e-04	5	83	2	PF14492
Domain	EFG_III-V	GFM1 EFTUD2	2.89e-04	6	83	2	IPR009022
Domain	EFG_C	GFM1 EFTUD2	2.89e-04	6	83	2	SM00838
Domain	FAD_binding_1	NOS1 NOS2	2.89e-04	6	83	2	PF00667
Domain	EFG_C	GFM1 EFTUD2	2.89e-04	6	83	2	PF00679
Domain	FAD-binding_1	NOS1 NOS2	2.89e-04	6	83	2	IPR003097
Domain	-	NOS1 NOS2	2.89e-04	6	83	2	1.20.990.10
Domain	NADPH_Cyt_P450_Rdtase_dom3	NOS1 NOS2	2.89e-04	6	83	2	IPR023173
Domain	-	GFM1 EFTUD2	4.04e-04	7	83	2	3.30.70.240
Domain	EFG_V	GFM1 EFTUD2	4.04e-04	7	83	2	IPR000640
Domain	FLAVODOXIN_LIKE	NOS1 NOS2	5.37e-04	8	83	2	PS50902
Domain	Gprotein_alpha_I	GNAI2 GNAT1	5.37e-04	8	83	2	IPR001408
Domain	Flavodoxin/NO_synth	NOS1 NOS2	5.37e-04	8	83	2	IPR008254
Domain	DHC_N1	DNAH5 DYNC1H1	5.37e-04	8	83	2	PF08385
Domain	Flavdoxin-like	NOS1 NOS2	5.37e-04	8	83	2	IPR001094
Domain	Flavodoxin_1	NOS1 NOS2	5.37e-04	8	83	2	PF00258
Domain	Dynein_heavy_dom-1	DNAH5 DYNC1H1	5.37e-04	8	83	2	IPR013594
Domain	Flavoprotein-like_dom	NOS1 NOS2	8.58e-04	10	83	2	IPR029039
Domain	Flavoprot_Pyr_Nucl_cyt_Rdtase	NOS1 NOS2	8.58e-04	10	83	2	IPR001709
Domain	-	NOS1 NOS2	8.58e-04	10	83	2	3.40.50.360
Domain	DOCK_C	DOCK2 DOCK11	1.05e-03	11	83	2	IPR010703
Domain	DHR-1_domain	DOCK2 DOCK11	1.05e-03	11	83	2	IPR027007
Domain	DHR_2	DOCK2 DOCK11	1.05e-03	11	83	2	PS51651
Domain	DHR_1	DOCK2 DOCK11	1.05e-03	11	83	2	PS51650
Domain	DOCK-C2	DOCK2 DOCK11	1.05e-03	11	83	2	PF14429
Domain	DHR-2	DOCK2 DOCK11	1.05e-03	11	83	2	IPR027357
Domain	DHR-2	DOCK2 DOCK11	1.05e-03	11	83	2	PF06920
Domain	DOCK	DOCK2 DOCK11	1.05e-03	11	83	2	IPR026791
Domain	OxRdtase_FAD/NAD-bd	NOS1 NOS2	1.25e-03	12	83	2	IPR001433
Domain	NAD_binding_1	NOS1 NOS2	1.25e-03	12	83	2	PF00175
Domain	G_TR_1	GFM1 EFTUD2	1.47e-03	13	83	2	PS00301
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DYNC1H1	1.72e-03	14	83	2	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DYNC1H1	1.72e-03	14	83	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH5 DYNC1H1	1.72e-03	14	83	2	IPR013602
Domain	DHC_N2	DNAH5 DYNC1H1	1.72e-03	14	83	2	PF08393
Domain	MT	DNAH5 DYNC1H1	1.72e-03	14	83	2	PF12777
Domain	AAA_8	DNAH5 DYNC1H1	1.72e-03	14	83	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH5 DYNC1H1	1.72e-03	14	83	2	IPR011704
Domain	AAA_5	DNAH5 DYNC1H1	1.72e-03	14	83	2	PF07728
Domain	DHC_fam	DNAH5 DYNC1H1	1.97e-03	15	83	2	IPR026983
Domain	Dynein_heavy_dom	DNAH5 DYNC1H1	1.97e-03	15	83	2	IPR004273
Domain	Dynein_heavy	DNAH5 DYNC1H1	1.97e-03	15	83	2	PF03028
Domain	G-alpha	GNAI2 GNAT1	2.25e-03	16	83	2	PF00503
Domain	GproteinA_insert	GNAI2 GNAT1	2.25e-03	16	83	2	IPR011025
Domain	-	GNAI2 GNAT1	2.25e-03	16	83	2	1.10.400.10
Domain	G_alpha	GNAI2 GNAT1	2.25e-03	16	83	2	SM00275
Domain	Gprotein_alpha_su	GNAI2 GNAT1	2.54e-03	17	83	2	IPR001019
Domain	EFTu-like_2	GFM1 EFTUD2	2.85e-03	18	83	2	IPR004161
Domain	GTP_EFTU_D2	GFM1 EFTUD2	2.85e-03	18	83	2	PF03144
Domain	G_TR_2	GFM1 EFTUD2	2.85e-03	18	83	2	PS51722
Domain	Fd_Rdtase_FAD-bd	NOS1 NOS2	3.18e-03	19	83	2	IPR017927
Domain	FAD_FR	NOS1 NOS2	3.18e-03	19	83	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	NOS1 NOS2	3.18e-03	19	83	2	IPR017938
Domain	-	GFM1 EFTUD2	3.88e-03	21	83	2	3.30.230.10
Domain	Ribosomal_S5_D2-typ_fold_subgr	GFM1 EFTUD2	4.25e-03	22	83	2	IPR014721
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	WBP2 POLR2B DIAPH2 CDK11A TFG CYFIP2 EFTUD2	1.26e-07	154	87	7	16055720
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DST DOCK11 HECTD4 DIAPH2 GRIK2 TACC3 HCN2 NOS1 DYNC1H1 RASAL2 CYFIP2 FERMT3 EFTUD2	8.00e-07	963	87	13	28671696
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DCAF13 SMCHD1 POLR2B ASNS BMS1 DARS1 SAMHD1 XPO1 GFM1 TFG DNAH5 DYNC1H1 RASAL2 CYFIP2 EFTUD2	2.35e-06	1425	87	15	30948266
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	SLC12A2 SMCHD1 ASNS DARS1 XPO1 GFM1 TFG DYNC1H1 EFTUD2	3.57e-06	484	87	9	31995728
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	DST SLC12A2 DOCK11 SMCHD1 POLR2B HECTD4 NOS2 EFTUD2	3.72e-06	363	87	8	14691545
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	DST SLC12A2 PI4KB BMS1 TACC3 ANKRD50 TFG ANO3 DYNC1H1 RASAL2 EFTUD2	3.86e-06	777	87	11	35844135
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	IFIH1 DOCK11 POLR2B DIAPH2 CDK11A XPO1 DNAI7 ANO3 MAP3K4	4.42e-06	497	87	9	36774506
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	RUFY2 VPS18 SNX4 DST SLC12A2 PI4KB DIAPH2 ANKRD50 RASAL2	4.95e-06	504	87	9	34432599
Pubmed	Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.	ORAI1 ORAI3	6.19e-06	2	87	2	19887627
Pubmed	Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins.	DPH3 DPH3P1	6.19e-06	2	87	2	14527407
Pubmed	Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development.	DPH3 DPH3P1	6.19e-06	2	87	2	16648478
Pubmed	Differential Redox Regulation of Ca²⁺ Signaling and Viability in Normal and Malignant Prostate Cells.	ORAI1 ORAI3	6.19e-06	2	87	2	26445441
Pubmed	Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.	NOS1 NOS2	6.19e-06	2	87	2	7682706
Pubmed	The role of nitric oxide synthases in the sleep responses to tumor necrosis factor-alpha.	NOS1 NOS2	6.19e-06	2	87	2	15157956
Pubmed	Effects of ethanol on neutrophil recruitment and lung host defense in nitric oxide synthase I and nitric oxide synthase II knockout mice.	NOS1 NOS2	6.19e-06	2	87	2	10512307
Pubmed	Communication between N terminus and loop2 tunes Orai activation.	ORAI1 ORAI3	6.19e-06	2	87	2	29237733
Pubmed	[Expression of cell adhesion molecule and nitric oxide synthase in nasal mucosa in allergic rhinitis].	NOS1 NOS2	6.19e-06	2	87	2	16780147
Pubmed	Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-alpha on hypothalamic insulin-dependent inhibition of food intake.	NOS1 NOS2	6.19e-06	2	87	2	16876161
Pubmed	Silencing of diphthamide synthesis 3 (Dph3) reduces metastasis of murine melanoma.	DPH3 DPH3P1	6.19e-06	2	87	2	23185508
Pubmed	Role of nitric oxide synthase in the development of bone cancer pain and effect of L-NMMA.	NOS1 NOS2	6.19e-06	2	87	2	26648027
Pubmed	A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest.	DCAF1 SAMHD1	6.19e-06	2	87	2	22776683
Pubmed	Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.	NOS1 NOS2	6.19e-06	2	87	2	1379716
Pubmed	A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles.	NOS1 NOS2	6.19e-06	2	87	2	14976216
Pubmed	Family-based association study between NOS-I and -IIA polymorphisms and autism spectrum disorders in Korean trios.	NOS1 NOS2	6.19e-06	2	87	2	18563708
Pubmed	Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis.	DPH3 DPH3P1	6.19e-06	2	87	2	24422557
Pubmed	The spinal cord expression of neuronal and inducible nitric oxide synthases and their contribution in the maintenance of neuropathic pain in mice.	NOS1 NOS2	6.19e-06	2	87	2	21179208
Pubmed	Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes.	NOS1 NOS2	6.19e-06	2	87	2	12738065
Pubmed	Deficiency of iNOS does not attenuate severe congestive heart failure in mice.	NOS1 NOS2	6.19e-06	2	87	2	15319210
Pubmed	Association between inducible and neuronal nitric oxide synthase polymorphisms and recurrent depressive disorder.	NOS1 NOS2	6.19e-06	2	87	2	20888049
Pubmed	Mechanistic studies on the intramolecular one-electron transfer between the two flavins in the human neuronal nitric-oxide synthase and inducible nitric-oxide synthase flavin domains.	NOS1 NOS2	6.19e-06	2	87	2	12777376
Pubmed	Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease.	NOS1 NOS2	6.19e-06	2	87	2	10581083
Pubmed	Functional variants in NOS1 and NOS2A are not associated with progressive hearing loss in Ménière's disease in a European Caucasian population.	NOS1 NOS2	6.19e-06	2	87	2	21612410
Pubmed	Role of nitric oxide and nuclear factor-kappaB in the CYP2E1 potentiation of tumor necrosis factor alpha hepatotoxicity in mice.	CYP2E1 NOS2	6.19e-06	2	87	2	19063961
Pubmed	Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases.	NOS1 NOS2	6.19e-06	2	87	2	28800639
Pubmed	Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study.	NOS1 NOS2	6.19e-06	2	87	2	12490535
Pubmed	Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3.	ORAI1 ORAI3	6.19e-06	2	87	2	18420579
Pubmed	A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast cancer cells.	ORAI1 ORAI3	6.19e-06	2	87	2	20395295
Pubmed	Intra- and inter-molecular effects of a conserved arginine residue of neuronal and inducible nitric oxide synthases on FMN and calmodulin binding.	NOS1 NOS2	6.19e-06	2	87	2	23507581
Pubmed	Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase.	NOS1 NOS2	6.19e-06	2	87	2	23904594
Pubmed	Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis.	NOS1 NOS2	6.19e-06	2	87	2	14660484
Pubmed	Role of inducible or neuronal nitric oxide synthase in neurogenesis of the dentate gyrus in aged mice.	NOS1 NOS2	6.19e-06	2	87	2	21082337
Pubmed	Pyroptotic and apoptotic cell death in iNOS and nNOS overexpressing K562 cells: A mechanistic insight.	NOS1 NOS2	6.19e-06	2	87	2	31881190
Pubmed	Inducible nitric oxide synthase is involved in acid-induced gastric hyperemia in rats and mice.	NOS1 NOS2	6.19e-06	2	87	2	12646421
Pubmed	Chronic alcohol consumption induces an overproduction of NO by nNOS- and iNOS-expressing myenteric neurons in the murine small intestine.	NOS1 NOS2	6.19e-06	2	87	2	21470341
Pubmed	Nitric oxide synthases: roles, tolls, and controls.	NOS1 NOS2	6.19e-06	2	87	2	7522969
Pubmed	Contribution of inducible and neuronal nitric oxide synthases to mitochondrial damage and melatonin rescue in LPS-treated mice.	NOS1 NOS2	6.19e-06	2	87	2	28110436
Pubmed	Determinants of lentiviral Vpx-CRL4 E3 ligase-mediated SAMHD1 degradation in the substrate adaptor protein DCAF1.	DCAF1 SAMHD1	6.19e-06	2	87	2	31003777
Pubmed	Influenza virus-induced sleep responses in mice with targeted disruptions in neuronal or inducible nitric oxide synthases.	NOS1 NOS2	6.19e-06	2	87	2	15220315
Pubmed	Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis.	NOS1 NOS2	6.19e-06	2	87	2	20655878
Pubmed	Oxidative stress and regulation of anti-oxidant enzymes in cytochrome P4502E1 transgenic mouse model of non-alcoholic fatty liver.	CYP2E1 NOS2	6.19e-06	2	87	2	20594230
Pubmed	Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels.	ORAI1 ORAI3	6.19e-06	2	87	2	17991693
Pubmed	Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion.	DPH3 DPH3P1	6.19e-06	2	87	2	31566424
Pubmed	Are Orai1 and Orai3 channels more important than calcium influx for cell proliferation?	ORAI1 ORAI3	6.19e-06	2	87	2	24321771
Pubmed	Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling.	ORAI1 ORAI3	6.19e-06	2	87	2	20354224
Pubmed	Facilitation of Orai3 targeting and store-operated function by Orai1.	ORAI1 ORAI3	6.19e-06	2	87	2	25791427
Pubmed	Role of Nitric Oxide in Stress-Induced Anxiety: From Pathophysiology to Therapeutic Target.	NOS1 NOS2	6.19e-06	2	87	2	28061969
Pubmed	Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.	NOS1 NOS2	6.19e-06	2	87	2	1372907
Pubmed	Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study.	NOS1 NOS2	6.19e-06	2	87	2	17328085
Pubmed	Increased nitric oxide caused by the ketogenic diet reduces the onset time of kainic acid-induced seizures in ICR mice.	NOS1 NOS2	6.19e-06	2	87	2	16460714
Pubmed	Orai1 and Orai3 act through distinct signalling axes to promote stemness and tumorigenicity of breast cancer stem cells.	ORAI1 ORAI3	6.19e-06	2	87	2	39135143
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DCAF1 DCAF13 DST SMCHD1 POLR2B ASNS BMS1 DARS1 GNAI2 EIF3F XPO1 DYNC1H1 RASAL2 EFTUD2	6.47e-06	1353	87	14	29467282
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	DCAF13 POLR2B ASNS DARS1 SAMHD1 EIF3F TBC1D23 DNAH5 DYNC1H1 MAP3K4	1.07e-05	704	87	10	29955894
Pubmed	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.	ASNS DARS1 GNAI2 XPO1 DYNC1H1	1.22e-05	118	87	5	27377895
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DCAF13 DST SMCHD1 POLR2B BMS1 DARS1 GNAI2 ITPRID2 EIF3F XPO1 DYNC1H1 RASAL2 EFTUD2	1.44e-05	1257	87	13	36526897
Pubmed	The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.	VPS18 DST IFT57 DARS1 XPO1 PLOD2 MAP3K4 GNPAT	1.85e-05	453	87	8	27113764
Pubmed	Human immunodeficiency virus-1-infected macrophages induce inducible nitric oxide synthase and nitric oxide (NO) production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome.	NOS1 NOS2	1.85e-05	3	87	2	10068656
Pubmed	Remodeling of channel-forming ORAI proteins determines an oncogenic switch in prostate cancer.	ORAI1 ORAI3	1.85e-05	3	87	2	24954132
Pubmed	Crucial roles of nitric oxide synthases in β-adrenoceptor-mediated bladder relaxation in mice.	NOS1 NOS2	1.85e-05	3	87	2	27784691
Pubmed	Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy.	NOS1 NOS2	1.85e-05	3	87	2	11717657
Pubmed	Murine ORAI2 splice variants form functional Ca2+ release-activated Ca2+ (CRAC) channels.	ORAI1 ORAI3	1.85e-05	3	87	2	17463004
Pubmed	Estrogen induces nitric oxide production via activation of constitutive nitric oxide synthases in human neuroblastoma cells.	NOS1 NOS2	1.85e-05	3	87	2	15242984
Pubmed	Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice.	NOS1 NOS2	1.85e-05	3	87	2	14551061
Pubmed	Nitric oxide synthases and heart failure - lessons from genetically manipulated mice.	NOS1 NOS2	1.85e-05	3	87	2	23774658
Pubmed	Human immunodeficiency virus infection, inducible nitric oxide synthase expression, and microglial activation: pathogenetic relationship to the acquired immunodeficiency syndrome dementia complex.	NOS1 NOS2	1.85e-05	3	87	2	10443886
Pubmed	Intragraft iNOS induction during human liver allograft rejection depresses cytochrome p450 activity.	CYP2E1 NOS2	1.85e-05	3	87	2	15349722
Pubmed	Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression levels.	THRSP CYP2E1	1.85e-05	3	87	2	29656332
Pubmed	Paradoxical roles of different nitric oxide synthase isoforms in colonic injury.	NOS1 NOS2	1.85e-05	3	87	2	14665440
Pubmed	Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease.	NOS1 NOS2	1.85e-05	3	87	2	24192154
Pubmed	Deletion of neuronal NOS prevents impaired vasodilation in septic mouse skeletal muscle.	NOS1 NOS2	1.85e-05	3	87	2	17258180
Pubmed	Cutting edge: nitric oxide inhibits the NLRP3 inflammasome.	NOS2 NLRP3	1.85e-05	3	87	2	23100513
Pubmed	Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity.	NOS1 NOS2	1.85e-05	3	87	2	15469894
Pubmed	Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus.	ORAI1 ORAI3	1.85e-05	3	87	2	29237734
Pubmed	[Polymorphic markers of the NO synthase genes and genetic predisposition to diabetic polyneuropathy in patients with type 1 diabetes mellitus].	NOS1 NOS2	1.85e-05	3	87	2	15856945
Pubmed	Metabolic profile and nitric oxide synthase expression of skeletal muscle fibers are altered in patients with type 1 diabetes.	NOS1 NOS2	1.85e-05	3	87	2	18465682
Pubmed	CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties.	ORAI1 ORAI3	1.85e-05	3	87	2	17442569
Pubmed	Subunit interactions of endothelial nitric-oxide synthase. Comparisons to the neuronal and inducible nitric-oxide synthase isoforms.	NOS1 NOS2	1.85e-05	3	87	2	8995432
Pubmed	nNOS deficiency-induced cell proliferation depletes the neurogenic reserve.	NOS1 NOS2	1.85e-05	3	87	2	22027181
Pubmed	Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly.	DCAF1 SAMHD1	1.85e-05	3	87	2	28202763
Pubmed	Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels.	ORAI1 ORAI3	1.85e-05	3	87	2	17452328
Pubmed	Pulmonary nitric oxide synthases and nitrotyrosine: findings during lung development and in chronic lung disease of prematurity.	NOS1 NOS2	1.85e-05	3	87	2	16950998
Pubmed	Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport.	XPO1 NOS2	1.85e-05	3	87	2	23471078
Pubmed	Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation.	NOS1 NOS2	1.85e-05	3	87	2	25389974
Pubmed	Structural basis of lentiviral subversion of a cellular protein degradation pathway.	DCAF1 SAMHD1	1.85e-05	3	87	2	24336198
Pubmed	Stabilization of SAMHD1 by NONO is crucial for Ara-C resistance in AML.	DCAF1 SAMHD1	1.85e-05	3	87	2	35803902
Pubmed	EFTUD2 Is a Novel Innate Immune Regulator Restricting Hepatitis C Virus Infection through the RIG-I/MDA5 Pathway.	IFIH1 EFTUD2	1.85e-05	3	87	2	25878102
Pubmed	Increase in Red Blood Cell-Nitric Oxide Synthase Dependent Nitric Oxide Production during Red Blood Cell Aging in Health and Disease: A Study on Age Dependent Changes of Rheologic and Enzymatic Properties in Red Blood Cells.	NOS1 NOS2	1.85e-05	3	87	2	25902315
Pubmed	Differential expression of nitric oxide synthases (NOS 1-3) in human skeletal muscle following exercise countermeasure during 12 weeks of bed rest.	NOS1 NOS2	1.85e-05	3	87	2	15180967
Pubmed	Alterations in nitric oxide synthase isoforms in acute lower limb ischemia and reperfusion.	NOS1 NOS2	1.85e-05	3	87	2	18024942
Pubmed	mRNA expressions of inducible nitric oxide synthase, endothelial nitric oxide synthase, and neuronal nitric oxide synthase genes in meningitis patients.	NOS1 NOS2	1.85e-05	3	87	2	21204701
Pubmed	Nitric oxide synthase in the vestibulocochlear system of mice.	NOS1 NOS2	1.85e-05	3	87	2	9824677
Interaction	TNIK interactions	DST DOCK11 PI4KB GRIK2 XPO1 ANKRD50 NOS1 DYNC1H1 CYFIP2 EPHA5 EFTUD2	4.56e-07	381	83	11	int:TNIK
Cytoband	3q12.2	TBC1D23 TFG	1.27e-04	9	87	2	3q12.2
GeneFamily	ORAI calcium release-activated calcium modulators	ORAI1 ORAI3	2.43e-05	3	52	2	668
GeneFamily	WD repeat domain containing\|DDB1 and CUL4 associated factors	DCAF1 DCAF13	1.21e-03	18	52	2	498
Coexpression	PUJANA_ATM_PCC_NETWORK	DOCK2 SNX4 SMCHD1 POLR2B BMS1 DARS1 SFI1 EIF3F XPO1 GNAT1 ITGAD RNF114 NOS2 RGS13 NLRP3	5.07e-05	1394	87	15	M9585
Coexpression	GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN	ORAI1 FRAS1 ITPRID2 GNAT1 PLOD2 RGS13	5.38e-05	199	87	6	M9751
Coexpression	GSE17721_LPS_VS_POLYIC_1H_BMDC_DN	SORT1 ORAI1 BMP6 BMS1 DIAPH2 EPHA5	5.38e-05	199	87	6	M3800
Coexpression	GSE22886_NAIVE_CD4_TCELL_VS_48H_ACT_TH2_UP	CLUHP3 TCEAL4 ELF2 SAMHD1 RNF114 P3H4	5.53e-05	200	87	6	M4528
Coexpression	GSE32128_INOS_DEPENDENT_VS_INOS_INDEPENDENT_ACTIVATED_TCELL_UP	WBP2 SNX4 AHI1 ITPRID2 TBC1D23 EPHA5	5.53e-05	200	87	6	M8605
Coexpression	QI_PBMC_ZOSTAVAX_AGE_50_75YO_CORRELATED_WITH_CONTRACTION_OF_VZV_SPECIFIC_T_CELLS_PEAK_TO_28DY_AT_1DYPOSITIVE	WBP2 IFIH1 ELF2 GNAI2 RNF114 B4GALT5 EFTUD2	5.65e-05	294	87	7	M40873
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 TMPRSS15 SFI1 DNAH5 ANO3 EPHA5	1.65e-06	184	87	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 TMPRSS15 SFI1 DNAH5 ANO3 EPHA5	1.65e-06	184	87	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 TMPRSS15 SFI1 DNAH5 ANO3 EPHA5	1.65e-06	184	87	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	RUFY2 SMCHD1 SFI1 XPO1 ITGAD MAP3K4	1.76e-06	186	87	6	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DST SLC12A2 SMCHD1 CALCRL ANKRD50 DYNC1H1	2.68e-06	200	87	6	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	NS-control-d_0-4-Epithelial-Ciliated-diff\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IFT57 DIAPH2 DNAI7 CCDC65 DNAH5	8.76e-06	142	87	5	1e57c75e9f28aae2ca99543448433fa7326398ad
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORT1 DOCK2 SLC12A2 SFI1 ITGAD	1.42e-05	157	87	5	ec433d2fe827abdb647be4176c231b7052482b6f
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORT1 DOCK2 SLC12A2 SFI1 ITGAD	1.71e-05	163	87	5	8dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORT1 DOCK2 SLC12A2 SFI1 ITGAD	1.71e-05	163	87	5	fd243ca223079033be480a24817a399f281fa4d4
ToppCell	facs-Lung-24m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK2 SLC12A2 SAMHD1 B4GALT5 CYFIP2	1.97e-05	168	87	5	c0aef5947b1d7e2c81a7481c509feda1687fcd7f
ToppCell	facs-Lung-24m-Hematologic-myeloid-non-classical_monocyte\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK2 SLC12A2 SAMHD1 B4GALT5 CYFIP2	1.97e-05	168	87	5	c861f80aa12caf54a94d93e38539ff41dc5227a6
ToppCell	control-Epithelial-Ciliated-diff\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	IFT57 DIAPH2 DNAI7 CCDC65 DNAH5	2.09e-05	170	87	5	334c4103eb6e021766f5638a4ab14b59ad085ac7
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DOCK11 PTPRO SCN5A GRIK2 NOS1	2.47e-05	176	87	5	05ec715439f2eb1696f5d8855da0dd1dd70effd0
ToppCell	Bronchial_Biopsy-Immune-Neutrophils\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	DOCK2 DOCK11 RGS13 NLRP3 FERMT3	2.67e-05	179	87	5	8c50e13927c09de05c86cd90dd6f71cee004b0d3
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRO GRIK2 TBC1D23 PLOD2 CYFIP2	2.82e-05	181	87	5	4e81ec1580e9acb22c32c465eb46f83d1e9e424e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRO GRIK2 TBC1D23 PLOD2 CYFIP2	2.82e-05	181	87	5	ad30c01290fb98adbd0caed301a584761212c977
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRO GRIK2 TBC1D23 PLOD2 CYFIP2	2.82e-05	181	87	5	3a3268a4dff8ffcb79e09f46490e138c96f8d916
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2\|TCGA-Skin / Sample_Type by Project: Shred V9	SORT1 GFM1 DYNC1H1 RASAL2 EPHA5	2.82e-05	181	87	5	9d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCell	facs-Aorta-Heart-3m-Myeloid-leukocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 PTPRO TACC3 CYFIP2 FERMT3	2.97e-05	183	87	5	062ec08d66c923f90fee771b1bf8d98bdc7e6c1b
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	RUFY2 SMCHD1 SFI1 XPO1 MAP3K4	3.13e-05	185	87	5	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 DOCK11 SAMHD1 RGS13 NLRP3	3.65e-05	191	87	5	468b5149d1533f03521844d3cce8633d44eb6ed4
ToppCell	PBMC-Mild\|PBMC / Compartment, Disease Groups and Clusters	IFIH1 SMCHD1 ELF2 SAMHD1 RNF114	3.93e-05	194	87	5	d1366b169d14011194e61d16b6b0953349febc78
ToppCell	COVID-19-kidney-TAL\|kidney / Disease (COVID-19 only), tissue and cell type	BMP6 DST ITPRID2 DNAH5 NOS1	4.12e-05	196	87	5	04f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCell	Control-Classical_Monocyte-cMono_2\|Classical_Monocyte / Disease condition and Cell class	DOCK2 SMCHD1 GNAI2 SAMHD1 FERMT3	4.22e-05	197	87	5	eb7610c9496a95a5fd866e16abcbc39b83abe617
ToppCell	TCGA-Skin-Metastatic-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	DOCK2 DCAF1 DOCK11 SAMHD1 CALCRL	4.33e-05	198	87	5	af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCell	TCGA-Skin-Metastatic\|TCGA-Skin / Sample_Type by Project: Shred V9	DOCK2 DCAF1 DOCK11 SAMHD1 CALCRL	4.33e-05	198	87	5	ad39cce004867f083f8da1954e0cf5a263815184
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	DOCK2 DCAF1 DOCK11 SAMHD1 CALCRL	4.33e-05	198	87	5	62cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DST SLC12A2 ITPRID2 CALCRL DYNC1H1	4.54e-05	200	87	5	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DST SLC12A2 ITPRID2 CALCRL DYNC1H1	4.54e-05	200	87	5	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SLC12A2 SMCHD1 SAMHD1 CALCRL DYNC1H1	4.54e-05	200	87	5	89821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	IFIH1 SMCHD1 SAMHD1 XPO1 DYNC1H1	4.54e-05	200	87	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Control_saline-Endothelial-Endothelial-Activated_Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	SLC12A2 SMCHD1 SAMHD1 CALCRL DYNC1H1	4.54e-05	200	87	5	be55cef682ba87250dad97689332c8820b3a7420
Drug	CsCl	ZNF17 ORAI1 ORAI3 HCN2 GFM1 NOS2 ANO3	8.43e-07	136	86	7	CID000024293
Disease	Immunoglobulin A deficiency (disorder)	IFIH1 AHI1	4.45e-05	4	81	2	C0162538
Disease	lissencephaly (implicated_via_orthology)	NOS1 NOS2 DYNC1H1	5.56e-05	27	81	3	DOID:0050453 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	SLC12A2 SCN5A NOS1 NOS2 DYNC1H1	8.83e-05	163	81	5	DOID:1826 (implicated_via_orthology)
Disease	Aicardi-Goutieres Syndrome 2	IFIH1 SAMHD1	1.11e-04	6	81	2	C3489724
Disease	AICARDI-GOUTIERES SYNDROME 1	IFIH1 SAMHD1	1.11e-04	6	81	2	C0796126
Disease	Autoinflammatory disorder	IFIH1 SAMHD1 NLRP3	1.22e-04	35	81	3	C3860213
Disease	Pseudo-TORCH syndrome	IFIH1 SAMHD1	1.55e-04	7	81	2	C3489725
Disease	Cerebellar Diseases	AHI1 NOS1	1.55e-04	7	81	2	C0007760
Disease	AICARDI-GOUTIERES SYNDROME	IFIH1 SAMHD1	2.06e-04	8	81	2	C0393591
Disease	McCune Albright syndrome (implicated_via_orthology)	GNAI2 GNAT1	2.06e-04	8	81	2	DOID:1858 (implicated_via_orthology)
Disease	response to darapladib, cardiovascular event measurement	ANKRD50 ANO3	2.06e-04	8	81	2	EFO_0006919, EFO_0008395
Disease	Aicardi-Goutieres syndrome (is_implicated_in)	IFIH1 SAMHD1	2.65e-04	9	81	2	DOID:0050629 (is_implicated_in)
Disease	Seizures	IFIH1 SAMHD1 EIF3F NOS1 NOS2	3.41e-04	218	81	5	C0036572
Disease	retinopathy of prematurity (biomarker_via_orthology)	NOS1 NOS2	4.83e-04	12	81	2	DOID:13025 (biomarker_via_orthology)
Disease	Psoriasis	IFIH1 RNF114 NOS2	5.24e-04	57	81	3	C0033860
Disease	Pustulosis of Palms and Soles	IFIH1 RNF114 NOS2	5.24e-04	57	81	3	C0030246
Disease	Malignant neoplasm of liver	CYP2E1 PTPRO ASNS GRIK2	6.42e-04	142	81	4	C0345904
Disease	Liver neoplasms	CYP2E1 PTPRO ASNS GRIK2	6.42e-04	142	81	4	C0023903
Disease	extrinsic allergic alveolitis (is_marker_for)	CYP2E1 NOS2	6.63e-04	14	81	2	DOID:841 (is_marker_for)
Disease	Asbestosis	NOS2 NLRP3	6.63e-04	14	81	2	C0003949
Disease	Pulmonary Fibrosis - from Asbestos Exposure	NOS2 NLRP3	6.63e-04	14	81	2	C2930617
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	CYP2E1 EIF3F NOS1 NOS2	7.31e-04	147	81	4	DOID:9352 (biomarker_via_orthology)
Disease	hepatic encephalopathy (biomarker_via_orthology)	NOS1 NOS2	7.64e-04	15	81	2	DOID:13413 (biomarker_via_orthology)
Disease	visceral:subcutaneous adipose tissue ratio	VPS18 TBC1D23 TRAK1	9.55e-04	70	81	3	EFO_0004767
Disease	myeloid white cell count	IFIH1 AHI1 HECTD4 DARS1 XPO1 CALCRL PSKH2 NLRP3 RASAL2	1.07e-03	937	81	9	EFO_0007988
Disease	activities of daily living score measurement	GRIK2 NOS1	1.51e-03	21	81	2	EFO_0008451
Disease	impotence (biomarker_via_orthology)	NOS1 NOS2	1.66e-03	22	81	2	DOID:1875 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
HMMELFDTTVEQLYS	AHSA2P	206	Q719I0
QEYVEHQVDDAMMAN	ASNS	486	P08243
EELMQAYQCHVTEEM	AHI1	186	Q8N157
KEIHYLQDIFMAMEQ	CCDC65	166	Q8IXS2
VMMVDLLAHTNYTFE	EPHA5	426	P54756
LDDMGYIVENDVIMH	COQ6	136	Q9Y2Z9
TMETLHLEYFEEAMN	ACOT2	261	P49753
HMEMVQVLIAYHADV	ANKRD50	991	Q9ULJ7
NDIRAEMDDMNEVYH	DIAPH2	396	O60879
DINMSEIGMDYIHEL	B4GALT5	126	O43286
EEEENAEMTDQYMAV	BMS1	466	Q14692
MVHMDHVSAVLDVDY	DCAF13	276	Q9NV06
YLVQEMMYEAELEHL	ANO3	951	Q9BYT9
MAHEAMEYDVQVQLN	RFWD3	1	Q6PCD5
EMPYMDAVVHEIQRF	CYP2E1	346	P05181
MVAMVEVQLESDHEY	ORAI3	76	Q9BRQ5
EDHIYQEEMLEMAQK	NOS2	1021	P35228
CSYTHEQIVEMMEFL	DCAF1	561	Q9Y4B6
IFETEDQVYMVMELA	PSKH2	126	Q96QS6
DIDSDDHQVMYIMKE	FRAS1	2106	Q86XX4
YDMVLVEDDEVNRMH	GNAT1	226	P11488
FELMRELTHMEYDLE	DST	3251	Q03001
DIAMMHLEFKVNYTD	TMPRSS15	876	P98073
MVAMVEVQLDADHDY	ORAI1	101	Q96D31
NYHDETGEIMDNLML	NUDT9	286	Q9BW91
MAVFHDEVEIEDFQY	DPH3	1	Q96FX2
KEEYMAFMNDFLEHE	RASAL2	526	Q9UJF2
EMLEEGHEYAVMLYT	CYFIP2	71	Q96F07
MYQVGLMETDQHIEF	HECTD4	3881	Q9Y4D8
QTMVYHHMTEEERFE	ITPRID2	986	P28290
VMEHYADQDDLVVMF	PLOD2	96	O00469
FDAKVMSMEEYDIVH	NOS1	786	P29475
FRINYADEMQDVMHF	PTPRO	1081	Q16827
AQMEMVLEEDEVYNA	ITGAD	1086	Q13349
TFSMMKHEDVEEVYV	C1QTNF3	166	Q9BXJ4
ENYNMFMEDAETHGI	HABP2	226	Q14520
MAVFHDEVEIEDFQY	DPH3P1	1	Q9H4G8
AAYHMFVVMEDLVEK	IFT57	36	Q9NWB7
EDAGMMDVHYSEEVL	DOCK11	1681	Q5JSL3
LFNIMMEHSQSDEYD	DOCK2	656	Q92608
DMHAFVTEVAYKMEL	GNPAT	361	O15228
VAVDMEFAKNMYELH	EIF3F	146	O00303
IEHETVNDFREKMMY	IFIH1	841	Q9BYX4
DADMVMSFVNLVEYD	BMP6	211	P22004
LYHMVKDFASEEAME	DNAI7	676	Q6TDU7
NMDKIYIVMNYVEHD	CDK11A	496	Q9UQ88
YMMQDVAEEQEVETE	ELF2	61	Q15723
QMVAEEAMCHYEDIR	MAN2C1	586	Q9NTJ4
LMHVAYEEFEKVMVA	DYNC1H1	401	Q14204
MTTDAALMYDAVHVV	GRIK2	316	Q13002
MHADMMEDVEEVYAG	GFM1	401	Q96RP9
EEIFHMTYDLASAVM	HCN2	351	Q9UL51
AEEVYDYIMHILMHF	CALCRL	361	Q16602
MMIHITDVAFIYQNE	DNAH5	1931	Q8TE73
FEEAQKIVYMHMERD	RGS13	121	O14921
FGVELHREEMYIFME	MAP3K4	1406	Q9Y6R4
EMQEEDFVQRAMDYF	NLRP3	636	Q96P20
HYMLLCAEEAAQFEM	SFI1	361	A8K8P3
DYTIHFIEEMMPENF	DROSHA	626	Q9NRR4
YSILAANDDMVFMHV	SORT1	351	Q99523
HELMQYDLEMAAQDL	SNX4	321	O95219
MDRFEEVVYQAMEEV	TACC3	676	Q9Y6A5
IAGDIMHNLIFQMYD	SMCHD1	1061	A6NHR9
MHNLIFQMYDEGERE	SMCHD1	1066	A6NHR9
YEYHALMMEEEGAVI	RUFY2	136	Q8WXA3
EDFIVDVINMDYGMQ	SAMHD1	496	Q9Y3Z3
YDLVLAEDEEMNRMH	GNAI2	231	P04899
LEHYNMTSEFEEMLQ	SCN5A	736	Q14524
EHIIYDFEDPEMMEM	POLR2B	286	P30876
IEMAFNYHYHEVMEE	DARS1	291	P14868
NMYIHMDEDVGDAIK	PI4KB	181	Q9UBF8
EMVLEIHQLFMDHEY	CLUHP3	71	Q96NS8
DKYAECMEMLHEAQE	TRAK1	331	Q9UPV9
YKEAIHDMNFSNEDM	TCEAL4	141	Q96EI5
AYLEAENLEMHDRME	TUFT1	331	Q9NNX1
MHASILAYMFNLVEE	XPO1	941	O14980
FVDYDVDEEDMMNQV	RNF114	206	Q9Y508
IHNEDITYDELVLMM	TFG	26	Q92734
EFTHMYLQSDDEMEL	P3H4	371	Q92791
GDTEHMVYFAVIMQD	VPS18	551	Q9P253
DMRDVDMYINLFHDA	SLC12A2	896	P55011
EEEDMYMNMVLAHFL	TBC1D23	406	Q9NUY8
CTEEEMMVFAALQYH	FERMT3	286	Q86UX7
SMVDFLEVVHMIYQL	STRCP1	1206	A6NGW2
VTVYEMDFLADLMDN	EFTUD2	111	Q15029
VMDRYAAEVHNMEQV	THRSP	16	Q92748
MNLTEDYMVFEDVAI	ZNF17	1	P17021
ILMSYDHVELTFNDM	WBP2	21	Q969T9