Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	pyrimidine nucleotide transmembrane transporter activity	SLC25A36 SLC25A33	2.81e-06	2	34	2	GO:0015218
GeneOntologyMolecularFunction	ADP-ribosylglutamate hydrolase activity	MACROD1 MACROD2	8.43e-06	3	34	2	GO:0140293
GeneOntologyMolecularFunction	nucleotide transmembrane transporter activity	SLC25A36 SLC25A33	1.44e-03	33	34	2	GO:0015215
GeneOntologyMolecularFunction	organophosphate ester transmembrane transporter activity	SLC25A36 SLC25A33	2.00e-03	39	34	2	GO:0015605
GeneOntologyMolecularFunction	deacetylase activity	MACROD1 MACROD2	2.11e-03	40	34	2	GO:0019213
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing N-glycosyl compounds	MACROD1 MACROD2	2.21e-03	41	34	2	GO:0016799
GeneOntologyBiologicalProcess	pyrimidine nucleotide transport	SLC25A36 SLC25A33	2.80e-06	2	35	2	GO:0006864
GeneOntologyBiologicalProcess	pyrimidine nucleotide import into mitochondrion	SLC25A36 SLC25A33	2.80e-06	2	35	2	GO:1990519
GeneOntologyBiologicalProcess	peptidyl-glutamate ADP-deribosylation	MACROD1 MACROD2	8.38e-06	3	35	2	GO:0140291
GeneOntologyBiologicalProcess	protein de-ADP-ribosylation	MACROD1 MACROD2	4.18e-05	6	35	2	GO:0051725
Domain	A1pp	MACROD1 MACROD2	1.22e-04	9	35	2	SM00506
Domain	Macro	MACROD1 MACROD2	1.22e-04	9	35	2	PF01661
Domain	Macro_dom	MACROD1 MACROD2	1.52e-04	10	35	2	IPR002589
Domain	MACRO	MACROD1 MACROD2	1.52e-04	10	35	2	PS51154
Domain	RCC1	HERC2 HERC1	6.35e-04	20	35	2	PF00415
Domain	RCC1_3	HERC2 HERC1	7.01e-04	21	35	2	PS50012
Domain	RCC1_1	HERC2 HERC1	7.01e-04	21	35	2	PS00625
Domain	RCC1_2	HERC2 HERC1	7.01e-04	21	35	2	PS00626
Domain	Reg_chr_condens	HERC2 HERC1	7.70e-04	22	35	2	IPR000408
Domain	-	HERC2 HERC1	7.70e-04	22	35	2	2.130.10.30
Domain	RCC1/BLIP-II	HERC2 HERC1	8.42e-04	23	35	2	IPR009091
Domain	HECT	HERC2 HERC1	1.16e-03	27	35	2	PF00632
Domain	HECTc	HERC2 HERC1	1.16e-03	27	35	2	SM00119
Domain	HECT_dom	HERC2 HERC1	1.16e-03	27	35	2	IPR000569
Domain	HECT	HERC2 HERC1	1.16e-03	27	35	2	PS50237
Domain	SOLCAR	SLC25A36 SLC25A33	4.43e-03	53	35	2	PS50920
Domain	Mito_carr	SLC25A36 SLC25A33	4.43e-03	53	35	2	PF00153
Domain	-	SLC25A36 SLC25A33	4.43e-03	53	35	2	1.50.40.10
Domain	Mt_carrier_dom	SLC25A36 SLC25A33	4.43e-03	53	35	2	IPR023395
Domain	Mitochondrial_sb/sol_carrier	SLC25A36 SLC25A33	4.43e-03	53	35	2	IPR018108
Pathway	WP_MEVALONATE_PATHWAY	ACAT2 MVK	4.42e-05	7	21	2	M46454
Pathway	KEGG_MEDICUS_REFERENCE_MEVALONATE_PATHWAY	ACAT2 MVK	1.38e-04	12	21	2	M47946
Pathway	WP_MEVALONATE_ARM_OF_CHOLESTEROL_BIOSYNTHESIS_PATHWAY	ACAT2 MVK	1.63e-04	13	21	2	M42544
Pathway	KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS	ACAT2 MVK	2.19e-04	15	21	2	M13465
Pathway	WP_COVID19_STRUCTURAL_COVERAGE_MAP	MACROD1 MACROD2	6.72e-04	26	21	2	M48318
Pathway	REACTOME_CHOLESTEROL_BIOSYNTHESIS	ACAT2 MVK	7.25e-04	27	21	2	MM14735
Pathway	REACTOME_CHOLESTEROL_BIOSYNTHESIS	ACAT2 MVK	7.25e-04	27	21	2	M16227
Pathway	WP_ENTEROCYTE_CHOLESTEROL_METABOLISM	ACAT2 MVK	1.29e-03	36	21	2	M48067
Pubmed	Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.	MACROD1 MACROD2	9.84e-07	2	35	2	21257746
Pubmed	Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae.	SLC25A36 SLC25A33	9.84e-07	2	35	2	12887330
Pubmed	A family of macrodomain proteins reverses cellular mono-ADP-ribosylation.	MACROD1 MACROD2	9.84e-07	2	35	2	23474712
Pubmed	Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice.	MACROD1 MACROD2	9.84e-07	2	35	2	33578760
Pubmed	The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters.	SLC25A36 SLC25A33	9.84e-07	2	35	2	25320081
Pubmed	Comparative analysis of MACROD1, MACROD2 and TARG1 expression, localisation and interactome.	MACROD1 MACROD2	2.95e-06	3	35	2	32427867
Pubmed	Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.	MACROD1 MACROD2	5.90e-06	4	35	2	23474714
Pubmed	Biochemical and Morphological Characterization of a Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase, MACRO Domain Containing 2.	MACROD1 MACROD2	5.90e-06	4	35	2	30227424
Pubmed	Detecting rare variants for complex traits using family and unrelated data.	HJV MACROD2	2.06e-05	7	35	2	19847924
Pubmed	The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.	HERC2 HERC1	2.06e-05	7	35	2	9949213
Pubmed	LMO4 functions as a co-activator of neurogenin 2 in the developing cortex.	FOXP1 NEUROG2	4.40e-05	10	35	2	21652654
Pubmed	Genome-wide association study and meta-analysis of intraocular pressure.	PKHD1 FOXP1	6.45e-05	12	35	2	24002674
Pubmed	A Ctnnb1 enhancer regulates neocortical neurogenesis by controlling the abundance of intermediate progenitors.	FOXP1 NEUROG2	7.62e-05	13	35	2	35915089
Pubmed	Ascl1 is a required downstream effector of Gsx gene function in the embryonic mouse telencephalon.	FOXP1 NEUROG2	7.62e-05	13	35	2	19208224
Pubmed	Two-marker association tests yield new disease associations for coronary artery disease and hypertension.	HJV MACROD2	7.62e-05	13	35	2	21626137
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	JAK3 FLNC TBC1D9B PNPLA6 HERC2 HERC1 KIAA2013	9.89e-05	1105	35	7	35748872
Pubmed	Differential expression of the Tmem132 family genes in the developing mouse nervous system.	FOXP1 NEUROG2	1.17e-04	16	35	2	35690356
Pubmed	Functional dissection of the Pax6 paired domain: Roles in neural tube patterning and peripheral nervous system development.	FOXP1 NEUROG2	1.33e-04	17	35	2	26187199
Pubmed	Slit/Robo signaling modulates the proliferation of central nervous system progenitors.	FOXP1 NEUROG2	2.46e-04	23	35	2	23083737
Pubmed	AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.	PKHD1 SCNN1D PRSS16	2.48e-04	121	35	3	31900314
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	FLNC TBC1D9B HERC2 KIAA2013	2.70e-04	313	35	4	38270169
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HERC2 HERC1	3.15e-04	26	35	2	26949039
Pubmed	Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord.	FOXP1 NEUROG2	3.93e-04	29	35	2	30846445
Pubmed	Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells.	FOXP1 NEUROG2	4.20e-04	30	35	2	25804738
Pubmed	Developmental trajectories of thalamic progenitors revealed by single-cell transcriptome profiling and Shh perturbation.	FOXP1 NEUROG2	4.49e-04	31	35	2	36476860
Pubmed	The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence.	FOXP1 NEUROG2	5.73e-04	35	35	2	20943929
Pubmed	A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.	ACAT2 MVK	6.41e-04	37	35	2	26108225
Pubmed	Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling.	FOXP1 NEUROG2	6.76e-04	38	35	2	25936505
Cytoband	1p36.22	SLC25A33 KIAA2013	3.70e-04	37	35	2	1p36.22
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	SCNN1D SLC25A33 KIAA2013 AKR7A2	1.74e-03	681	35	4	chr1p36
Disease	actinic keratosis	FOXP1 HERC2	1.16e-04	14	34	2	EFO_0002496
Disease	wellbeing measurement	PKHD1 FOXP1 HERC1 PRSS16 KLHDC8B	1.11e-03	692	34	5	EFO_0007869
Disease	response to cranial radiation therapy, short-term memory	FOXP1 MACROD2	2.19e-03	60	34	2	EFO_0004335, EFO_0010950

Protein segments in the cluster

Peptide	Gene	Start	Entry
LGGLGLGLGGGDCRV	AKR7A2	86	O43488
LGGGPRATDGHRGQC	FAM220A	131	Q7Z4H9
SRVFGHSGGPCGGLL	ARHGEF39	286	Q8N4T4
GGGVGSGGLCRALRS	HJV	71	Q6ZVN8
ALGGHDGLGLLRVAG	JAK3	261	P52333
LVLGGGGARGCSHIG	PNPLA6	981	Q8IY17
ETLRLADHCGGGGGG	NEUROG2	166	Q9H2A3
CGDGGRLGHGDTVPL	HERC2	521	O95714
GGVDAGLRVGGRCVH	HERC1	2311	Q15751
VTVSIGGHGLGACLG	FLNC	1641	Q14315
GGSNHLLECGGLREG	FOXP1	21	Q9H334
GGLLAVALALGGRGC	EVC2	16	Q86UK5
GLHLGLGRGCGAMIG	MFSD6	576	Q6ZSS7
SLLGGGGVDGCIHRA	MACROD1	176	Q9BQ69
VGSLGGHIVAIGGLG	KLHDC8B	276	Q8IXV7
RSGVVLGRGGGAMGH	SDR39U1	156	Q9NRG7
RGGGPCGFTSAGHVL	SCNN1D	61	P51172
GGIAGLGAAQRLCGH	PAOX	21	Q6QHF9
SCLHGGRLLGYGGAA	MN1	126	Q10571
LGGGGVDGCIHRAAG	MACROD2	96	A1Z1Q3
GVGGGAGAALGNRTH	RPRML	16	Q8N4K4
TLVHLFAGGCGGTVG	SLC25A36	6	Q96CQ1
GEHGLRACLEPGGLG	SWSAP1	176	Q6NVH7
GCLGGRLVHVFGAGF	PKHD1	1746	P08F94
FGRVVHGSACGGGVL	PKHD1	2556	P08F94
TLLHLFAGGCGGTVG	SLC25A33	11	Q9BSK2
GHGRGGGLTGLLVGT	TBC1D9B	31	Q66K14
LGGHRGTGELGAALS	USP21	126	Q9UK80
GGAIALGHPLGASGC	ACAT2	346	Q9BWD1
GGGGLFRGCSPLLTH	TRAPPC14	111	Q8WVR3
GCGPALGATGLGHFG	SSC4D	386	Q8WTU2
GLHSKLTGAGGGGCG	MVK	326	Q03426
LGEVGGHLGGAAVCL	ZBTB7C	511	A1YPR0
GDRRKGLLGCVGSGH	nan	31	Q5VSD8
LCGLLLGGGGNRSHS	PRSS16	311	Q9NQE7
GGSGARRAAGGLHLL	KIAA2013	36	Q8IYS2
VHGGLLGAGCRGVGG	LRFN4	611	Q6PJG9