Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainLRRC37AB_C

LRRC37A LRRC37A3 LRRC37A2

1.39e-074623PF14914
DomainLRRC37_N

LRRC37A LRRC37A3 LRRC37A2

1.39e-074623IPR032754
DomainLRRC37AB_C

LRRC37A LRRC37A3 LRRC37A2

1.39e-074623IPR029423
DomainLRRC37

LRRC37A LRRC37A3 LRRC37A2

1.39e-074623PF15779
DomainLRRC37A/B-like

LRRC37A LRRC37A3 LRRC37A2

1.39e-074623IPR015753
DomainZnf_C2H2-like

ZNF106 PRDM10 ZNF48 ZNF296 TAX1BP1 CIZ1 ZNF629 ZNF496 PRDM15 ZNF646

2.69e-047966210IPR015880
DomainZnf_C2H2

ZNF106 PRDM10 ZNF48 ZNF296 TAX1BP1 CIZ1 ZNF629 ZNF496 PRDM15 ZNF646

2.94e-048056210IPR007087
DomainZnF_C2H2

ZNF106 PRDM10 ZNF48 ZNF296 TAX1BP1 CIZ1 ZNF629 ZNF496 PRDM15 ZNF646

3.03e-048086210SM00355
DomainZINC_FINGER_C2H2_1

ZNF106 PRDM10 ZNF48 ZNF296 CIZ1 ZNF629 ZNF496 PRDM15 ZNF646

1.00e-03777629PS00028
DomainGAGE

XAGE5 PAGE1

1.79e-0319622IPR031320
DomainGAGE

XAGE5 PAGE1

1.79e-0319622SM01379
DomainSynaptotagmin

PCLO C2CD5

1.98e-0320622IPR001565
Domainzf-C2H2

ZNF106 PRDM10 ZNF48 ZNF296 ZNF629 ZNF496 PRDM15 ZNF646

1.99e-03693628PF00096
DomainZnf_C2H2_jaz

PRDM10 CIZ1

2.40e-0322622IPR022755
Domainzf-C2H2_jaz

PRDM10 CIZ1

2.40e-0322622PF12171
DomainGAGE

XAGE5 PAGE1

2.85e-0324622PF05831
DomainGAGE_fam

XAGE5 PAGE1

3.10e-0325622IPR008625
DomainZINC_FINGER_C2H2_2

ZNF106 PRDM10 ZNF48 ZNF296 ZNF629 ZNF496 PRDM15 ZNF646

3.95e-03775628PS50157
DomainSH3

EFS DLG1 ARHGAP27 TP53BP2

5.75e-03216624SM00326
DomainSH3

EFS DLG1 ARHGAP27 TP53BP2

5.75e-03216624PS50002
DomainSH3_domain

EFS DLG1 ARHGAP27 TP53BP2

6.13e-03220624IPR001452
Domain-

PRDM10 ZNF48 ZNF296 ZNF629 ZNF496 PRDM15 ZNF646

7.07e-036796273.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

PRDM10 ZNF48 ZNF296 ZNF629 ZNF496 PRDM15 ZNF646

7.93e-03694627IPR013087
DomainWW

BAG3 ARHGAP27

1.06e-0247622PF00397
DomainWW

BAG3 ARHGAP27

1.11e-0248622SM00456
DomainSET_dom

PRDM10 PRDM15

1.20e-0250622IPR001214
DomainSET

PRDM10 PRDM15

1.20e-0250622PS50280
DomainWW_DOMAIN_2

BAG3 ARHGAP27

1.25e-0251622PS50020
DomainWW_DOMAIN_1

BAG3 ARHGAP27

1.25e-0251622PS01159
Pubmed

Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.

LRRC37A LRRC37A3 LRRC37A2

2.16e-08462322419166
Pubmed

Evolutionary dynamism of the primate LRRC37 gene family.

LRRC37A LRRC37A3 LRRC37A2

6.42e-071062323064749
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

NUSAP1 PWWP2A EPS15L1 TAX1BP1 CIZ1 ZNF629 XRCC1 PRDM15 TP53BP2

2.07e-0664562925281560
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

NUSAP1 PAGE1 ZNF106 EPS15L1 TOX4 ARRB1 POP1 CIZ1 TRIOBP TACC2 CFAP97

5.56e-061155621120360068
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

MEAF6 NUSAP1 PWWP2A FLYWCH1 CIZ1 KDM3B XRCC1 PRDM15

1.23e-0560862836089195
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

MEAF6 NUSAP1 PWWP2A ZNF106 TOX4 ZNF48 FLYWCH1 POP1 CIZ1 ZNF629 XRCC1

1.61e-051294621130804502
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PIK3R4 ZNF106 EXPH5 BAG3 ZNF629 KDM3B TMCC1 CFAP97 TP53BP2

2.10e-0586162936931259
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PWWP2A TOX4 EXPH5 POP1 ZNF629 TMCC1 C2CD5

2.76e-0549362715368895
Pubmed

Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97.

KCNJ2 DLG1

3.12e-05562211181181
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

EPS15L1 ARRB1 ZNF48 LRRC37A3 MRPL42 TAX1BP1 CIZ1 XRCC1 TMCC1

3.67e-0592562928986522
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

LRRC37A LRRC37A3 PCLO C2CD5

3.82e-051056249628581
Pubmed

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling.

RIPK1 TAX1BP1

4.67e-05662219131965
Pubmed

HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies.

TAX1BP1 BAG3

4.67e-05662236854646
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

EPS15L1 TOX4 BAG3 CIZ1 KDM3B DLG1 TP53BP2

5.46e-0554962738280479
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

NUSAP1 PWWP2A ARRB1 ZNF48 FLYWCH1 POP1 CIZ1 TRIOBP DLG1 XRCC1 TMCC1

6.09e-051497621131527615
Pubmed

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20.

RIPK1 TAX1BP1

6.53e-05762218246070
Pubmed

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation.

RIPK1 TAX1BP1

6.53e-05762218239685
Pubmed

A human MAP kinase interactome.

ZNF106 TOX4 ARRB1 RIPK1 EXPH5 BAG3

2.29e-0448662620936779
Pubmed

Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.

EPS15L1 TAX1BP1 TP53BP2 C2CD5

2.41e-0416962431462741
Pubmed

Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.

PRDM15 ZNF646

2.81e-041462222451204
Pubmed

Selection system for genes encoding nuclear-targeted proteins.

EPS15L1 TRIOBP

2.81e-04146229853615
Pubmed

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.

RIPK1 TAX1BP1

3.23e-041562221765415
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

PIK3R4 NUSAP1 TOX4 POP1 ZNF629 TACC2 XRCC1

3.98e-0475962735915203
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

ZNF106 EPS15L1 BAG3 POP1 KDM3B DLG1 C2CD5

4.47e-0477462715302935
Pubmed

Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins.

KCNJ2 DLG1

5.24e-041962215024025
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

TOX4 ZNF48 ZNF296 CIZ1 KDM3B ZNF496 ZNF646

5.77e-0480862720412781
Pubmed

Functional proteomics mapping of a human signaling pathway.

ZNF106 TOX4 EXPH5 TAX1BP1 KDM3B TP53BP2

6.44e-0459162615231748
Pubmed

Characterization and mapping of human genes encoding zinc finger proteins.

ZNF48 ZNF629

7.06e-04226221946370
Pubmed

Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes.

ZNF48 ZNF629

7.06e-04226221505991
Pubmed

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis.

PRDM10 PRDM15

7.06e-042262219050759
Pubmed

Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.

KCNJ2 DLG1

7.72e-042362216637659
Pubmed

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.

MEAF6 PRDM10 MRPL42 POP1 ZNF629

8.93e-0441762536537216
Pubmed

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

ARRB1 EFS TAX1BP1 BAG3 PRKAG1 ODC1 ZNF496 TP53BP2 ZNF646

1.17e-03147762931515488
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

EPS15L1 CDH26 ARRB1 MRPL42 PRKAG1 TRIOBP DLG1 PRDM15 TMCC1

1.24e-03148962928611215
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

EPS15L1 TOX4 BAG3 CIZ1 KDM3B TACC2 TP53BP2

1.34e-0393462733916271
Pubmed

Identification of Redox and Glucose-Dependent Txnip Protein Interactions.

EPS15L1 TOX4

1.50e-033262227437069
Pubmed

Primary Ciliary Dyskinesia

DNAAF3 DNAH11

1.50e-033262220301301
Pubmed

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

EPS15L1 RIPK1 TP53BP2

1.75e-0313362315144186
Cytoband17q21.31

LRRC37A LRRC37A2 ARHGAP27

1.92e-048262317q21.31
Cytoband2p25

SOX11 ODC1

2.71e-04186222p25
Cytoband19q13.2

LIPE XRCC1 RINL

1.45e-0316462319q13.2
Cytoband3q22.1

PIK3R4 TMCC1

1.49e-03426223q22.1
Cytoband15q15.1

NUSAP1 ZNF106

1.87e-034762215q15.1
Cytoband16p11.2

ZNF48 ZNF629 ZNF646

2.24e-0319162316p11.2
CytobandEnsembl 112 genes in cytogenetic band chr11q24

PRDM10 SLC37A2 SPA17

2.24e-03191623chr11q24
Cytoband11q24.2

SLC37A2 SPA17

3.32e-036362211q24.2
CytobandEnsembl 112 genes in cytogenetic band chr16p11

ZNF48 ZNF629 ZNF646

6.38e-03278623chr16p11
CytobandEnsembl 112 genes in cytogenetic band chr17q24

LRRC37A3 KCNJ2

7.85e-0398622chr17q24
CytobandEnsembl 112 genes in cytogenetic band chr7p15

TAX1BP1 DNAH11

8.32e-03101622chr7p15
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF106 PRDM10 ZNF48 ZNF296 ZNF629 ZNF496 PRDM15 ZNF646

1.48e-0471840828
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

FLYWCH1 PCLO

4.92e-041540226
GeneFamilyZinc fingers C2H2-type|PR/SET domain family

PRDM10 PRDM15

6.36e-04174021197
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PCLO C2CD5

2.87e-0336402823
CoexpressionGSE28737_WT_VS_BCL6_HET_FOLLICULAR_BCELL_UP

SOX11 PRDM10 ZNF48 EXPH5 SPA17 TP53BP2

7.89e-06200626M9391
ToppCellnormal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells|normal_Lymph_Node / Location, Cell class and cell subclass

PIK3R4 LRRC37A LRRC37A3 ZNF629 ARHGAP27

4.55e-0617562529fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 ASXL3 FAT3 PCLO DNAH11

5.80e-06184625ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 ASXL3 FAT3 PCLO DNAH11

5.80e-061846252cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 ASXL3 FAT3 PCLO DNAH11

5.80e-061846252b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellNS-moderate-d_0-4-Epithelial|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ST6GALNAC1 ZNF106 EXPH5 TAX1BP1 TACC2

8.70e-0620062564462a18afca3c1a8548a857924b8166058bf958
Diseaseinvasive ductal carcinoma (is_implicated_in)

DLG1 XRCC1

2.21e-0411602DOID:3008 (is_implicated_in)
DiseaseMalignant neoplasm of breast

PIK3R4 LIPE LRRC37A TAX1BP1 POP1 LRRC37A2 TACC2 TP53BP2 ZNF646

3.02e-041074609C0006142
DiseaseKartagener syndrome (implicated_via_orthology)

DNAAF3 DNAH11

3.64e-0414602DOID:0050144 (implicated_via_orthology)
DiseaseParkinson disease

ASXL3 BAG3 ARHGAP27 PRDM15 ZNF646

4.94e-04321605MONDO_0005180
Diseaseneuroimaging measurement

SOX11 DNAAF3 ZNF106 EFS FAT3 TACC2 ARHGAP27 DNAH11

1.39e-031069608EFO_0004346
Diseasecolorectal adenoma

DNAAF3 FAT3

2.06e-0333602EFO_0005406
DiseasePrimary ciliary dyskinesia

DNAAF3 DNAH11

2.45e-0336602cv:C0008780
Diseasevisceral heterotaxy (implicated_via_orthology)

DNAAF3 DNAH11

2.59e-0337602DOID:0050545 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
NTQELHPDPFQTEDP

EPS15L1

611

Q9UBC2
PAVENEHPQETPESN

PRKAG1

11

P54619
PPEHPVENDVTQTVS

CFAP97

76

Q9P2B7
QDEDTPPQEHISPQI

DLG1

111

Q12959
NQDQPVPFNSSHPDE

GPR18

6

Q14330
AHANEEIPEQPPTLE

DNAH11

1066

Q96DT5
TNLIQNQPETPEHPE

ANGPTL3

146

Q9Y5C1
SNNEQHFTEVPVTPE

TP53BP2

11

Q13625
PETEPVSSVQENHEN

TP53BP2

676

Q13625
PHREVPENETPVDTN

ARRB1

361

P49407
ESLTNSHEEPQIAPP

ASXL3

481

Q9C0F0
SHEEPQIAPPEDNLE

ASXL3

486

Q9C0F0
AEGPEPEADSQEQVH

PAGE1

96

O75459
DTPPDIDLHNQASVP

KCNJ2

401

P63252
PSPTQQEAAAEHPQT

LRRC37A3

491

O60309
PSPTQQEAAAEHPQT

LRRC37A2

491

A6NM11
PSPTQQEAAAEHPQT

LRRC37A

491

A6NMS7
ERENAHPQPEDSSPS

KCNH7

996

Q9NS40
DQELPTQPEAPDEHQ

FLYWCH1

396

Q4VC44
TQPHEVSPEQPKDQE

PCLO

1436

Q9Y6V0
QGQENPPDHDPIHDQ

KDM3B

1636

Q7LBC6
ENQERNDSPVPTHDE

EXPH5

941

Q8NEV8
VEPPAHSDSLDPQTN

PRDM10

1106

Q9NQV6
AKVPSPPDEHQEAEN

NUSAP1

131

Q9BXS6
VNPHSLPDPEVNEQS

POP1

61

Q99575
PQHHGEPAENQDNPE

SLC37A2

241

Q8TED4
PVDPDSQADTVHSNP

DNAAF3

31

Q8N9W5
QSVPQQPEDEAKPHE

CMYA5

361

Q8N3K9
SIEDANDHTPEFQQP

FAT3

461

Q8TDW7
PDHSNEDQEVYVVPP

EFS

91

O43281
QVTDANDPPAFHPQS

CDH26

386

Q8IXH8
PDFHNQENEPSQEDP

MEAF6

126

Q9HAF1
NAEDPHTETQQPEAT

BAG3

541

O95817
SENQPPITHPNDQEA

DYNAP

41

Q8N1N2
KEIPFNEDPNPNTHS

C2CD5

266

Q86YS7
QNPDFPPEVEEQDAS

ODC1

421

P11926
QETPAQHDAESQKEP

LIPE

61

Q05469
QEPDEEDEEPPHQQL

SOX11

241

P35716
NEVHVPGDQDEPQTL

PWWP2A

541

Q96N64
EDENVPTAPDPPSQH

TAX1BP1

696

Q86VP1
DVQIHPQPEASNPQS

PRDM15

1426

P57071
QDLHVPPPEESAEQV

ARHGAP27

206

Q6ZUM4
QAPPEEQDKVPHTAQ

ST6GALNAC1

106

Q9NSC7
NHAFEEQEPPEKSDP

SPA17

71

Q15506
PSLEHPQEENEPSLQ

RIPK1

361

Q13546
PGTNDVPEQESHSQP

TRIOBP

1616

Q9H2D6
QEEQPTHQAPAEAAP

APOBR

946

Q0VD83
AQVSVQPPEQTHEQP

CIZ1

451

Q9ULV3
PNNEEIDEVTHPNGN

PIK3R4

511

Q99570
TPQETEPEAAQRHDP

RINL

186

Q6ZS11
QPNEFEHTPQEDDLG

ZNF48

36

Q96MX3
PLPDNSQEVATEDHN

THAP9

111

Q9H5L6
PRPDPVHNNEETHDQ

MRPL42

76

Q9Y6G3
HPSPNQDSEEADSIP

ZNF646

31

O15015
SPHDVQQIQADPEPE

TMCC1

66

O94876
DSSQIHVPVEPQEDN

TACC2

871

O95359
HVPVEPQEDNNLPTH

TACC2

876

O95359
PLDQEQEQLPVEPHS

ZNF496

146

Q96IT1
ENTDSEEHQEPPDLP

XRCC1

521

P18887
PPLQREDEPSSQHAD

TCHHL1

291

Q5QJ38
HQETHTQEKPPNPED

ZNF629

786

Q9UEG4
PEQDENVNAVPPSSA

ZNF106

1206

Q9H2Y7
PHSPADQPEQQAEST

ZNF106

1326

Q9H2Y7
NNSPEAHTVEAPSPE

TOX4

521

O94842
PQQEEPPTESQDHTP

XAGE5

31

Q8WWM1
QEQASAAPPEPAVHA

ZNF296

296

Q8WUU4